Immunoglobulin is normal. Normal human immunoglobulin
solution for intravenous administration
solution for intramuscular administration
solution for intravenous administration bottle (bottle) 25 ml, cardboard pack 1
solution for intramuscular administration 1.5 ml/dose 2 ml ampoule with ampoule knife, cardboard pack 10
solution for intramuscular administration 1.5 ml/dose 1.5 ml ampoule with ampoule knife, cardboard pack 10.
Composition and active substance
Normal human immunoglobulin contains:
pharmachologic effect
The drug is an immunologically active protein fraction isolated from human blood plasma of healthy donors, individually tested for the absence of antibodies to the human immunodeficiency virus (HIV-1 and HIV-2) and hepatitis C virus and hepatitis B virus surface antigen (HBsAg).
The drug has low anti-complementary activity as a result of treatment with a small amount of pepsin in a slightly acidic environment followed by removal of the enzyme with aluminum hydroxide.
Description
The drug is a clear or slightly opalescent colorless liquid with a protein concentration of 4.5% to 5.5%. Does not contain preservatives or antibiotics.
Biological and immunological properties
The active component of the drug are immunoglobulins, which have the activity of antibodies of various specificities. The drug also has nonspecific activity, which manifests itself in increasing the body's resistance.
What does normal human immunoglobulin help with: indications
Treatment of severe toxic forms of bacterial and viral infections, postoperative complications accompanied by septicemia in children and adults.
Contraindications
Immunoglobulin is not administered to persons with a history of allergic reactions to blood products. In cases of severe sepsis, the only contraindication for administration is a history of anaphylactic shock to blood products. For persons suffering from allergic diseases (bronchial asthma, atopic dermatitis, recurrent urticaria) or prone to allergic reactions, the drug is administered against the background of antihistamines. It is recommended to continue their administration for 8 days after the end of the course of treatment. During the period of exacerbation of the allergic process, the drug is administered according to the conclusion of an allergist for health reasons.
For persons suffering from diseases in the genesis of which immunological mechanisms are leading (collagenosis, immune blood diseases, nephritis), the drug is prescribed after consultation with an appropriate specialist.
The drug is used only as prescribed by a doctor.
The administration of Immunoglobulin is recorded in established accounting forms indicating the batch number, date of manufacture, expiration date, manufacturer, date of administration, dose and nature of the reaction to the administration of the drug.
Human immunoglobulin is normal during pregnancy and breastfeeding
Use caution during pregnancy and lactation.
Normal human immunoglobulin: instructions for use
Immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteal muscle or the outer surface of the thigh. The drug should not be administered intravenously. Before injection, ampoules with the drug are kept for 2 hours at room temperature.
The opening of the ampoules and the administration procedure are carried out in strict compliance with the rules of asepsis and antiseptics. To avoid foam formation, the drug is drawn into a syringe with a wide bore needle.
The drug cannot be stored in an opened ampoule. The drug is unsuitable for use in ampoules with damaged integrity or labeling, if there is a change in physical properties (change in color, clouding of the solution, the presence of flakes that do not break), if the expiration date has expired and storage conditions are not observed.
The dose of immunoglobulin and the frequency of its administration depend on the indications for use.
Prevention of hepatitis A.
children from 1 to 6 years old- 0.75 ml, up to 10 years— 1.5 ml, over 10 years old and adults- 3 ml. Repeated administration of immunoglobulin if necessary to prevent hepatitis A is indicated no earlier than after 2 months.
Preventing measles
The drug is administered once from the age of 3 months to persons who have not had measles and are not vaccinated against the infection, no later than 6 days after contact with the patient. The dose of the drug for children (1.5 or 3 ml) is determined depending on the state of health and the time that has passed since contact. For adults, as well as children in contact with mixed infections, the drug is administered in a dose of 3 ml.
Prevention and treatment of influenza
The drug is administered once in doses: children under 2 years old— 1.5 ml, from 2 to 7 years— 3 ml, over 7 years old and adults- 4.5-6 ml. When treating severe forms of influenza, repeated (after 24-48 hours) administration of immunoglobulin in the same dose is indicated.
Prevention of whooping cough
The drug is administered twice with an interval of 24 hours in a single dose of 3 ml to children who have not had whooping cough and have not been vaccinated (not fully vaccinated) against whooping cough, as early as possible after contact with the patient, but not later than 3 days.
Prevention of meningococcal infection.
The drug is administered once children aged 6 months to 7 years no later than 7 days after contact with a patient with a generalized form of meningococcal infection in doses of 1.5 ml (children under 3 years old) and 3 ml (children over 3 years old).
Prevention of polio
The drug is administered once in doses of 3-6 ml to unvaccinated or incompletely vaccinated children with polio vaccine as early as possible after contact with a patient with polio.
Treatment of hypo- and agammaglobulinemia
The drug is administered at a dose of 1 ml per 1 kg of body weight, the calculated dose can be administered in 2-3 doses with an interval of 24 hours. Subsequent administrations of immunoglobulin are carried out according to indications no earlier than after 1 month.
Increasing the body's resistance during the period of convalescence of acute infectious diseases with a protracted course and in chronic pneumonia.
The drug is administered in a single dose of 0.15-0.2 ml per 1 kg of body weight. The frequency of administration (up to 4 injections) is determined by the doctor; the intervals between injections are 2-3 days.
Side effects
As a rule, there are no reactions to the administration of immunoglobulin. Individuals with altered reactivity may develop allergic reactions of various types, and in extremely rare cases, anaphylactic shock, and therefore persons receiving the drug should be under medical supervision. Antishock therapy must be available in the room where the drug is administered.
For impaired renal function
Use caution in case of renal failure.
Use in childhood
Possible use according to indications according to the dosage regimen.
special instructions
Administration of immunoglobulin and preventive vaccinations.
Treatment with immunoglobulin preparations reduces the effectiveness of vaccination, so vaccinations are carried out no earlier than 2-3 months after the administration of immunoglobulin.
Persons suffering from allergic diseases (bronchial asthma, atopic dermatitis, recurrent urticaria) or prone to allergic reactions on the day of immunoglobulin administration and for the next 8 days are recommended to prescribe antihistamines. During the period of exacerbation of the allergic process, the drug is administered according to the conclusion of an allergist.
For persons suffering from autoimmune diseases (blood diseases, connective tissue diseases, nephritis, etc.), the drug should be administered against the background of appropriate therapy.
Immunoglobulin passes into breast milk and may help transfer protective antibodies to the newborn.
A temporary increase in antibodies in the blood after administration leads to false-positive test data in a serological test (Coombs test).
After administration of the drug, the patient's condition should be monitored for at least 30 minutes. Antishock therapy must be available in the room where the drug is administered. When anaphylactoid reactions develop, antihistamines, glucocorticosteroids and adrenergic agonists are used. During pregnancy, it is administered only according to strict indications, when the expected benefit to the mother outweighs the potential risk to the fetus.
Compatibility with other drugs
Not described.
Overdose
Not described.
Storage conditions and shelf life
The drug is stored and transported at a temperature of 2 to 8°C. Freezing is not allowed.
The best prevention of a disease is its prevention. The cost of the procedure is insignificant compared to the health preserved. Especially if the diseases are difficult to cure. There are drugs to stimulate the natural immune defense of the human body.
One of these is normal human immunoglobulin. These instructions for use are given strictly for educational and informational purposes.
Normal human immunoglobulin is a preparation based on a natural component of the human body, taken from fractions of donor blood. Beforehand, the blood goes through many stages of purification to reduce the presence of possible infections to zero. Therefore, normal human immunoglobulin is an absolutely safe and useful medicine for humans.
Various patient reviews confirm its effectiveness. Even during pregnancy (in rare cases), normal human immunoglobulin is used for introduction into the woman’s body. During pregnancy, adapted anti-Rhesus immunoglobulin is used. We will use anti-rhesus in several cases.
Active components
The main active ingredient is human immunoglobulin of normal protein origin. Contains water for injection and sodium chloride in very small quantities. Immunoglobulin is well known as an antitetanus drug for intramuscular administration. Also acquired other associations - human immunoglobulin against tick-borne encephalitis, measles, problems with the immune system.
But it cannot be taken as a medicine or vaccine. The drug is intended to strengthen the immune system in the fight against diseases or to develop a stable barrier against them. For example, the tetanus barrier. Human immunoglobulin against tick-borne encephalitis is a particularly valuable drug in spring and autumn.
Release form
On sale there is normal human immunoglobulin for intravenous liquid administration, as well as intramuscular immunoglobulin. The price of the drug is affordable, as is the possibility of purchasing human immunoglobulin. However, in domestic medicine only immunoglobulin is used for intramuscular administration.
Human immunoglobulin normal for intravenous administration liquid is used only in the form of a dropper. You can buy normal human immunoglobulin for intramuscular injection at a pharmacy with a doctor's prescription. The drug is packaged in ampoules of 1.5 and 3 ml.
Dosage and course of use of intramuscular medication
Normal human immunoglobulin has no limited instructions for use. The dose is calculated based on body weight, and the number of injections is calculated based on the severity of the patient’s condition. For example, an anti-tetanus injection for a child should not exceed the volume of 25 ml at a time. Or if human immunoglobin against tick-borne encephalitis is given to an adult, then its dose is not higher than 50 ml. The relationship of this dosage to the injection for any type of illness.
Indications for use
The use of normal human immunoglobulin for intramuscular administration, as the instructions say, is possible for a number of diseases:
- immune diseases, immunodeficiencies;
- postoperative periods;
- prevention of influenza diseases, measles, whooping cough, meningococci, polio, also has an antitetanus effect;
- human immunoglobulin against tick-borne encephalitis is also used;
- various infectious diseases, including sepsis;
- blood diseases;
- acquired immunodeficiency syndrome - AIDS, often in children;
- other.
Normal human immunoglobulin for intramuscular administration is placed in the gluteal muscle. The injection site is the upper lateral square of the buttock. The injection site is also used in the anterior outer part of the thigh.
Use of immunoglobulin during pregnancy and lactation
During pregnancy, normal human immunoglobulin should be used in strictly justified cases. No studies have been conducted on the reaction of organisms during pregnancy in women. Therefore, it is impossible to convince that there are no consequences at different stages of pregnancy.
During breastfeeding, it is also worth treating in a limited manner. It is better to reduce any medical interventions during pregnancy or lactation to zero. It is still known that during pregnancy, immunoglobulin is transferred to the child.
Antirhesus immunoglobulin during pregnancy
When the mother is Rh negative and the child is Rh positive, a serious conflict can arise. The price of which is sometimes very expensive: miscarriage, for example. Anti-Rhesus immunoglobulin during pregnancy, abortion, forced termination of pregnancy.
The drug anti-Rhesus immunoglobin is useful for prevention during the first pregnancy, when the Rhesus levels of the mother and child are different. The price of this procedure is affordable for young mothers.
Contraindications
Antirhesus immunoglobulin is contraindicated in persons with hypersensitivity. Human tetanus immunoglobulin for intramuscular administration does not leave any side effects. Studies have shown that there are no pathogenic reactions. No negative reviews or complaints were received after the administration of the intramuscular drug.
At the moment, no negative effects of the drug with other drugs for intramuscular administration on the human body have been found.
Conclusion
The cost of human health is immeasurable. Therefore, watch your health, get preventive vaccinations, even if you are far from a child. The cost of such techniques is low. Use natural medicines that do not harm your health with chemical composition. Reviews indicate the safety of this drug. Be healthy!
Immunoglobulin is an immunostimulating drug.
Release form
The drug is available in the form of a solution for intramuscular and intravenous administration, as well as in the form of a powder for injection.
pharmachologic effect
Immunoglobulin is a globular protein that is produced by special cells of the human body. Globular protein takes an active part in the formation of the immune response.
There are different types of proteins, including immunoglobulin G, immunoglobulin E, human immunoglobulin, anti-Rhesus immunoglobulin, immunoglobulins M and A. All these proteins differ in amino acid composition, structure and functions.
Immunoglobulin G accounts for about 70% of all serum proteins. Its most important functions include the ability to penetrate the placental barrier in order to provide the newborn with natural passive immunity. Immunoglobulin G takes part in the development of the immune response, participates in the activation of complement, and enhances phagocytosis. The production of this type of protein requires the presence of T lymphocytes. Taking immunosuppressants and radiation help suppress immunoglobulin G.
Immunoglobulin M accounts for 5-10% of the total amount of proteins. This type of protein is the first to be synthesized in the newborn body. Immunoglobulin M is an early antibody that fights viruses and gram-negative bacteria. The protein takes part in the activation of complement and enhances phagocytosis. This group of proteins includes antibodies against streptococcus, cold agglutinins, blood group agglutinins, and rheumatoid factor. They help attract phagocytes to the site of infection and activate phagocytosis. Immunoglobulins M are weakly specific - they can simultaneously bind up to 5 antigen molecules. Thus, large immune complexes are formed, which leads to the rapid removal of antigens from circulation and does not allow them to attach to cells.
The norm of immunoglobulin in children should be: at 1-3 months of a baby’s life - 0-2 kU/l, at 3-6 months - 3-10 kU/l, at 1 year - 8-20 kU/l, at 5 years - 10-50 kE/l, at 15 years old – 16-60 kE/l. For adults, the norm is 20-100 kE/l.
Immunoglobulin A accounts for 10-15% of the total. It is found in tears, saliva, gastric secretions, intestinal secretions, lungs, vagina, genitourinary tract, bronchi. A large amount of protein is contained in breast milk, thanks to which, during natural feeding, the baby is protected from the first days. This type of protein helps neutralize bacterial toxins and viruses, and also provides protection to mucous membranes.
Human immunoglobulin is distinguished by a high content of antibodies that fight various pathogens. It helps reduce the likelihood of contracting infections in patients with immunodeficiency and replenishes the lack of G-antibodies.
Anti-Rhesus immunoglobulin is introduced into a woman’s body during pregnancy when an Rh conflict is detected to prevent Rh sensitization. The protein promotes the destruction of fetal Rh-positive red blood cells in the mother's bloodstream, preventing the production of anti-Rh maternal antibodies.
Indications
Immunoglobulin G is prescribed for liver cirrhosis, infectious diseases, viral and chronic autoimmune hepatitis, dermatomyositis, myeloma, systemic lupus erythematosus, AIDS, rheumatoid arthritis, HIV infections, sepsis, meningitis, sinusitis, oncopathologies, otitis media, pneumonia.
Immunoglobulin E is effective for allergic diseases such as food and drug allergies, hay fever, atopic dermatitis, eczema, bronchial asthma, and helminthiases. The drug is also used to assess the development of allergies in children.
Human immunoglobulin should be taken for congenital hypogammaglobulinemia, agammaglobulinemia, severe combined immunodeficiency, deficiency of immunoglobulin G subclasses, for replacement therapy for myeloma, AIDS in children, chronic lymphocytic leukemia.
Anti-Rh immunoglobulin is prescribed to women who are Rh negative, in which Rh antibodies are not produced. It is also taken if it is necessary to terminate pregnancy artificially in women who are Rh negative.
Instructions for use (method and dosage)
The drug is administered intravenously or intramuscularly. The method of administration of the drug is determined by the doctor. The immunoglobulin level is determined by a specialist individually in each case, depending on the diagnosis.
Side effects
When taking certain levels of immunoglobulin in each individual case, side effects occur extremely rarely. As a rule, after completing the course they disappear almost immediately.
As a result of taking the drug, the patient may experience a dry cough, tachycardia, shortness of breath, stomach pain, diarrhea, nausea, cyanosis, chest pain, vomiting, drowsiness, sweating, hiccups. Side effects also include the occurrence of an allergic reaction, back pain, joint pain, necrosis of the renal tubules, and increased salivation.
Contraindications
The drug should not be taken in case of diabetes mellitus, renal failure, anaphylactic shock, or acute stage of allergy. The drug is prescribed with caution to pregnant women, during lactation, for chronic decompensated cardiac failure, and migraines.
Indications for use:The drug is prescribed for replacement therapy if there is a need to replenish and replace natural antibodies.
Immunoglobulin is used to prevent infections in:
- agammaglobulinemia;
- bone marrow transplantation;
- primary and secondary immunodeficiency syndrome;
- chronic lymphocytic leukemia;
- variable immunodeficiency associated with agammaglobulinemia;
- AIDS in children.
The product is also used for:
- thrombocytopenic purpura of immune origin;
- severe bacterial infections such as sepsis (in combination with antibiotics);
- viral infections;
- prevention of various infectious diseases in premature infants;
- Guillain-Barre syndrome;
- Kawasaki syndrome (usually in combination with the standard diseases for this disease);
- neutropenia of autoimmune origin;
- chronic demyelinating polyneuropathy;
- hemolytic anemia of autoimmune origin;
- erythrocyte aplasia;
- thrombocytopenia of immune origin;
- hemophilia caused by the synthesis of antibodies to factor P;
- treatment of myasthenia gravis;
- prevention of recurrent miscarriage.
Pharmachologic effect:
The drug is an immunomodulatory and immunostimulating agent. Contains a large number of neutralizing and opsonizing antibodies, thanks to which it effectively resists viruses, bacteria and other pathogens. The product also replenishes the number of missing IgG antibodies, thereby reducing the risk of infection in individuals with primary and secondary immunodeficiency. Immunoglobulin effectively replaces and replenishes natural antibodies in the patient's serum.
When administered intravenously, the bioavailability of the drug is 100%. There is a gradual redistribution of the active substance of the product between the extravascular space and human plasma. Equilibrium between these environments is achieved in approximately 1 week.
Immunoglobulin method of administration and dosage:
Immunoglobulin is administered intravenously by drip and intramuscularly. The dosage is prescribed strictly individually, taking into account the type and severity of the disease, the individual tolerance of the patient and the state of his immune system.
Immunoglobulin contraindications:
The drug should not be used for:
- hypersensitivity to human immunoglobulins;
- IgA deficiency due to the presence of antibodies to it;
- renal failure;
- exacerbation of the allergic process;
- diabetes mellitus;
- anaphylactic shock to blood products.
The product should be used with caution for migraines, pregnancy and lactation, and decompensated chronic heart failure. Also, if there are diseases in the genesis of which immunopathological mechanisms are the main ones (nephritis, collagenosis, immune blood diseases), then the product should be prescribed with caution following the conclusion of a specialist.
Immunoglobulin side effects:
If all recommendations for administration, dosage and precautions are followed when using the product, then the presence of serious side effects is very rare. Symptoms may appear several hours or even days after administration. Side effects almost always disappear when you stop taking Immunoglobulin. The majority of side effects are associated with the high rate of infusion of the product. By reducing the speed and temporarily stopping the intake, you can achieve the disappearance of the bulk of the effects. In other cases, symptomatic therapy is necessary.
Effects are most likely to occur when you first take the product: during the first hour. This could be a flu-like syndrome - malaise, chills, high body temperature, weakness, headache.
The following symptoms also occur:
- respiratory system (dry cough and shortness of breath);
- digestive system (nausea, diarrhea, vomiting, stomach pain and increased salivation);
cardiovascular system (cyanosis, tachycardia, chest pain, flushing of the face);
- central nervous system (drowsiness, weakness, rarely symptoms of aseptic meningitis - nausea, vomiting, headache, light sensitivity, impaired consciousness, stiff neck);
- kidneys (not often acute tubular necrosis, worsening renal failure in patients with impaired renal function).
Allergic (itching, bronchospasm, skin rash) and local (hyperemia at the site of intramuscular injection) reactions are also possible. Other side effects include: myalgia, aching joints, back pain, hiccups and sweating.
In very rare cases, collapse, loss of consciousness and severe hypertension have been observed. In these severe cases, discontinuation of the product is necessary. It is also possible to administer antihistamine products, adrenaline and plasma replacement solutions.
Pregnancy:
No studies have been conducted on the effect of the product on pregnant women. There is no information about the dangers of Immunoglobulin during pregnancy and lactation. But during pregnancy, this product is administered in cases of extreme need, when the benefits of the drug significantly outweigh the possible risk to the baby.
The product should be used with caution during lactation: it is known that it passes into mother's milk and promotes the transfer of protective antibodies to the infant.
Overdose:
Symptoms of overdose may appear with intravenous administration of the product - high blood viscosity and hypervolemia. This is especially true for people who are elderly or have impaired renal function.
Use with other medications:
The drug is pharmaceutically incompatible with other drugs. It should not be mixed with other products; a separate dropper should always be used for infusion. When using Immunoglobulin simultaneously with active immunization drugs for viral diseases such as rubella, chicken pox, measles, and mumps, the effectiveness of treatment may decrease. If parenteral use of live viral vaccines is necessary, they can be used after at least 1 month after taking Immunoglobulin. A more desirable waiting period is 3 months. If a large dose of Immunoglobulin is administered, its effect can last for a year. Also, this product should not be used in conjunction with calcium gluconate in infants. There are suspicions that this will lead to negative phenomena.
Release form:
The drug is available in two forms: lyophilized dry powder for infusion (IV administration), solution for IM injection.
Storage conditions:
The drug must be stored in a warm place, protected from light. The storage temperature should be 2-10°C; the medicine should not be frozen. The storage period will be indicated on the package. After this period, the product cannot be used.
Synonyms:
Immunoglobin, Imogam-RAJ, Intraglobin, Pentaglobin, Sandoglobin, Cytopect, Human normal immunoglobulin, Human antistaphylococcal immunoglobulin, Human tick-borne encephalitis immunoglobulin liquid, Human tetanus immunoglobulin, Venoglobulin, Imbiogam, Imbioglobulin, Human normal immunoglobulin (Immuno globulinum Humanum Normale), Sandoglobulin, Cytotect, Humaglobin, Octagam, Intraglobin, Endobulin S/D
Immunoglobulin composition:
The active substance of the product is the immunoglobulin fraction. It was isolated from human plasma, and then purified and concentrated. Immunoglobulin does not contain antibodies to hepatitis C viruses and human immunodeficiency, it does not contain antibiotics.
Additionally:
The drug should be used only as prescribed by a doctor. Do not use Immunoglobulin in damaged containers. If the transparency of the solution changes, flakes and suspended particles appear, then such a solution is unsuitable for use. When opening the container, the contents must be used immediately, since the already dissolved product cannot be stored.
The protective effect of this product begins to appear 24 hours after administration, its duration is 30 days. In patients with a tendency to migraine or with impaired renal function, increased caution must be exercised. You should also know that after using Immunoglobulin, there is a passive increase in the amount of antibodies in the blood. In serological testing, this may lead to false interpretation of the results.
The drug is dispensed from pharmacies according to a doctor's prescription.
Attention!
Before using the medication "Immunoglobulin" You should consult your doctor.
The instructions are provided for informational purposes only. Immunoglobulin».
Immunoglobulin- a concentrated solution of an immunologically active protein fraction isolated by fractionation with ethyl alcohol at temperatures below 0°C from the blood plasma of healthy donors. To produce a series of immunoglobulins, plasma obtained from at least 1000 healthy donors is used, individually tested for the absence of hepatitis B virus surface antigen (HBsAg), antibodies to the hepatitis C virus and the human immunodeficiency viruses HIV-1 and HIV-2.
The protein concentration in immunoglobulin ranges from 9.5 to 10.5%.
Stabilizer glycine at a concentration of (2.25±0.75)%. The drug does not contain preservatives or antibiotics.
The active principle is immunoglobulins, which have antibody activity of various specificities.
The drug also has nonspecific activity, increasing the body's resistance.
Pharmacokinetics
Cmax of antibodies in the blood is achieved after 24-48 hours, T1/2 of antibodies from the body is 3-4 weeks.Indications for use
Indications for use of the drug Immunoglobulin are:- prevention of hepatitis A, measles, whooping cough, meningococcal infection, polio, influenza;
- treatment of hypo- and agammaglobulinemia;
- to increase the body’s resistance during the period of convalescence of infectious diseases.
Mode of application
Immunoglobulin injected intramuscularly into the upper outer quadrant of the gluteal muscle or the outer surface of the thigh. The drug should not be administered intravenously. Before injection, ampoules with the drug are kept for 2 hours at room temperature.The opening of the ampoules and the administration procedure are carried out in strict compliance with the rules of asepsis and antiseptics. To avoid foam formation, the drug is drawn into a syringe with a wide bore needle.
The drug cannot be stored in an opened ampoule. The drug is unsuitable for use in ampoules with damaged integrity or labeling, if there is a change in physical properties (change in color, clouding of the solution, the presence of flakes that do not break), if the expiration date has expired and storage conditions are not observed.
The dose of immunoglobulin and the frequency of its administration depend on the indications for use.
Prevention of hepatitis A.
The drug is administered once in doses: children from 1 to 6 years old - 0.75 ml, up to 10 years old - 1.5 ml, over 10 years old and adults - 3 ml. Repeated administration of immunoglobulin if necessary to prevent hepatitis A is indicated no earlier than after 2 months.
Preventing measles
The drug is administered once from the age of 3 months to persons who have not had measles and are not vaccinated against the infection, no later than 6 days after contact with the patient. The dose of the drug for children (1.5 or 3 ml) is determined depending on the state of health and the time that has passed since contact. For adults, as well as children in contact with mixed infections, the drug is administered in a dose of 3 ml.
Prevention and treatment of influenza
The drug is administered once in doses: children under 2 years old - 1.5 ml, from 2 to 7 years old - 3 ml, over 7 years old and adults - 4.5-6 ml. When treating severe forms of influenza, repeated (after 24-48 hours) administration of immunoglobulin in the same dose is indicated.
Prevention of whooping cough
The drug is administered twice with an interval of 24 hours in a single dose of 3 ml to children who have not had whooping cough and have not been vaccinated (not fully vaccinated) against whooping cough, as early as possible after contact with the patient, but not later than 3 days.
Prevention of meningococcal infection.
The drug is administered once to children aged 6 months to 7 years no later than 7 days after contact with a patient with a generalized form of meningococcal infection in doses of 1.5 ml (children under 3 years old) and 3 ml (children over 3 years old).
Prevention of polio
The drug is administered once in doses of 3-6 ml to unvaccinated or incompletely vaccinated children with polio vaccine as early as possible after contact with a patient with polio.
Treatment of hypo- and agammaglobulinemia
The drug is administered at a dose of 1 ml per 1 kg of body weight, the calculated dose can be administered in 2-3 doses with an interval of 24 hours. Subsequent administrations of immunoglobulin are carried out according to indications no earlier than after 1 month.
Increasing the body's resistance during the period of convalescence of acute infectious diseases with a protracted course and in chronic pneumonia.
The drug is administered in a single dose of 0.15-0.2 ml per 1 kg of body weight. The frequency of administration (up to 4 injections) is determined by the doctor; the intervals between injections are 2-3 days.
Side effects
Reactions to administration Immunoglobulin, as a rule, are absent.In rare cases, local reactions may develop in the form of hyperemia and an increase in temperature to 37.5°C during the first day after administration of the drug.
Individual people with altered reactivity may develop allergic reactions of various types, and in extremely rare cases, anaphylactic shock; therefore, persons who have been administered the drug should be under medical supervision for 30 minutes after its administration.
Vaccination sites must be provided with anti-shock therapy.
Contraindications
The use of the drug is contraindicated Immunoglobulin with a history of severe allergic reactions to the administration of human blood products.For persons suffering from allergic diseases or with a history of severe allergic reactions, antihistamines are recommended on the day of immunoglobulin administration and for the next 3 days.
Persons suffering from systemic immunopathological diseases (blood diseases, connective tissue diseases, nephritis, etc.) should be administered immunoglobulin against the background of appropriate therapy.
Pregnancy
Use with caution Immunoglobulin during pregnancy and lactation.Interaction with other drugs
Therapy Immunoglobulin can be combined with other drugs, in particular antibiotics.The introduction of immunoglobulins can weaken (for 1.5-3 months) the effect of live vaccines against viral diseases such as measles, rubella, mumps and chicken pox (vaccinations with these vaccines should be carried out no earlier than after 3 months). After the administration of large doses of immunoglobulin, its effect can last in some cases up to one year. Do not use simultaneously with calcium gluconate in infants.
Overdose
Cases of drug overdose Immunoglobulin not described.Storage conditions
Storage and transportation in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8°C out of the reach of children. Freezing is not allowed.Shelf life - 2 years. A drug that has expired cannot be used.
Release form
Immunoglobulin - solution for intramuscular injection 1.5 ml/1 dose: amp. 5, 10 or 20 pcs.Compound
Immunoglobulin contains the active substance: human normal immunoglobulin.Additionally
Possible use Immunoglobulin in children according to indications.Do not use in infants with calcium gluconate.
Immunoglobulin is used only as prescribed by a doctor. The administration of immunoglobulin is recorded in established accounting forms indicating the batch number, release date, expiration date, manufacturer, date of administration, dose, nature of the reaction to the administration of the drug.
After the administration of immunoglobulin, vaccinations against measles and mumps are carried out no earlier than 3 months later. After vaccination against these infections, immunoglobulin should be administered no earlier than 2 weeks later; If it is necessary to use immunoglobulin earlier than this period, vaccination against measles or mumps should be repeated. Vaccinations against other infections can be carried out at any time before or after the administration of immunoglobulin.
Main settings
| Name: | IMMUNOGLOBULIN |
| ATX code: | J06BA01 - |
