Analogues of Monural are inexpensive and high-quality drugs. Medicinal reference book geotar

1 package of Phosphoral contains 5.631 g of fosfomycin trometamol, which is equivalent to 3 g of fosfomycin.
Excipients: tangerine flavor, orange flavor, saccharin, sucrose.

Indications

Phosphoral is used to treat acute uncomplicated infections urinary tract caused by microorganisms sensitive to fosfomycin. Prevention during diagnostic procedures and surgical interventions.

Contraindications

Contraindications to the use of the drug Phosphoral are: hypersensitivity to the components of the drug, severe renal failure (creatinine clearance - 10 ml/min), hemodialysis.

Directions for use and doses

Phosphoral is taken orally on an empty stomach. The contents of the package are dissolved in 125 ml (1/2 cup) cold water, stir until completely dissolved and drink. The dosage regimen is set individually.
Usually single dose for adults in acute phase disease is 3 g (1 packet) once.
In order to prevent urinary tract infections during surgical intervention, transurethral diagnostic studies take the contents of one package 3:00 before the intervention and the second package 24 hours after the intervention.
In more complex clinical cases(in elderly patients, with recurrent infectious diseases) or in case of infectious diseases caused by strains sensitive to antibiotic therapy in higher concentrations(Pseudomonas, Enterobacter, Proteus, indole-positive strains), a 3g dose of the drug is taken twice with an interval of 24 hours.

Overdose

The package contains 1 packet of the drug, so the risk of overdose is minimal. In case of an overdose of Phosphoral, it is recommended to drink a lot of fluid (to increase diuresis). Features of application.

Side effects

From the outside digestive tract: diarrhea, nausea, heartburn.
Possible allergic reactions, skin rashes.
Severe hypersensitivity reactions and anaphylactic shock are rare.

Use during pregnancy

The use of Phosphoral during pregnancy and breastfeeding is possible only for health reasons or if the expected effect of therapy for the mother exceeds the potential risk for the fetus/child. Adequate and strictly controlled studies on use during pregnancy have not been conducted. Therefore, the ability of fosfomycin to cross the placenta should be taken into account. Breastfeeding should be stopped during treatment.

Storage conditions

Store in original packaging at a temperature not exceeding 30 ° C.

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The description of the drug "Phosforal" on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.

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Cystitis - very unpleasant disease, which mainly affects women during menopause and pregnant women. In men, a disease associated with the urinary tract is called urethritis. Such problems require immediate treatment as they cause discomfort.

Monural is a Swiss drug that has proven itself well in convenient form applications. Monural has only one disadvantage - the price. It’s good that there are analogues of the drug, both domestic and imported, which are similar in composition and action.

The active ingredient of Monural is Fosfomycin. Studies of the effect of this substance on the body have proven its safety for use by both adults, pregnant women, and children.

Analogs of the drug according to the active substance

Exists large number domestic analogues of Monural, which are produced on the basis of fosfomycin. These include:

Ureacid

Release form: granules in a sachet for the preparation of a solution for oral administration.

Active ingredient: 1 sachet contains 3 grams of fosfomycin trometamol, calculated as fosfomycin.

Antimicrobial antibacterial agent, which is suitable for adults and children over 12 years of age. Ureacid is used to treat simple infections caused by microorganisms sensitive to fosfomycin.

Directions for use

The contents of one sachet should be poured into ½ glass of cold water, stir until completely dissolved and drink immediately.

Typically, a single dose for adults, including elderly patients in the acute phase of the disease is 3 grams (1 sachet) once.

Side effects

Gastrointestinal dysfunction, heartburn, nausea, diarrhea.

Contraindications

Hypersensitivity to the components of the drug, renal failure, increased level creatinine in blood and urine.

Urolysin

Release form: granules for oral use.

Active ingredient: birch leaf extract, knotweed herb, horsetail herb, kholmovoy solyanka herb, Kuril tea, chokeberry fruits, blueberry shoots, burdock roots, glucose.

The drug is suitable for the treatment of simple urinary tract infections and for prophylaxis during diagnostic procedures and surgical interventions. The age category ranges from 12 to 75 years.

Directions for use

• Dissolve 1 teaspoon of granules in 100 milliliters of warm water and take 3 times a day.
• The course of treatment is 4-6 weeks.
• After 2 weeks, repeat the course.

Use with caution in case of large kidney stones and gallbladder during exacerbations of urinary and cholelithiasis more than 4 times a year.

Side effects

Disorders of the gastrointestinal tract.

Release form: powder for the preparation of a solution for intravenous administration, white or white with a yellowish tint.

Used for infectious inflammatory processes pelvic organs and exacerbations of diseases genitourinary system. Suitable for anyone age category starting from newborns. Minimally toxic.

Directions for use

It is necessary to prepare a solution for intravenous infusion. The cooking method will vary depending on the disease. Details can be found in the instructions inside the box with the drug.

Side effects

1. Cramps,
2. dizziness,
3. diarrhea,
4. chills,
5. skin irritations.

Contraindications

Hypersensitivity to fosfomycin, predisposition to allergic reactions, liver diseases, renal failure, with heart failure, with arterial hypertension.

Antibiotic wide range actions for systemic use in powder form for intravenous injections. Prescribed for treatment bacterial infections genitourinary system, gynecological and surgical infections. Prohibited for use by children under 5 years of age.

Directions for use

Side effects

Rarely nausea, vomiting, diarrhea,
Contraindications:

Release form: powder for the preparation of solutions for intravenous infusions.

Active ingredient: Fosfomycin, Trometamol.

It is a broad-spectrum antibiotic. Used in the treatment and prevention of diseases of the genitourinary system, acute bacterial cystitis, exacerbation of chronic recurrent bacterial cystitis, acute bacterial urovesical syndrome, bacterial nonspecific urethritis, asymptomatic massive bacteriuria.

Directions for use

The application regimen is established individually for all ages and various diseases. Detailed instructions for preparing solutions for infusions can be found inside the package with the drug.

Side effects

Rarely appear

• nausea,
• vomit,
• diarrhea,
• skin rash that disappears on its own after discontinuation of fosfomycin.

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Active ingredient: Fosfomycin, Trometamol.

A drug with high antimicrobial effect for treatment acute cystitis caused by drug-resistant E. coli. Suitable for adults and children over 5 years old.

Directions for use

The drug is used once after bowel movement bladder, on an empty stomach, preferably before bedtime. For adults, the dosage is 3 grams, for children over 5 years old - 2 grams.

Side effects

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Release form: granules (powder) for solution (suspension).

Active ingredient: Fosfomycin, Trometamol.

Broad-spectrum antibacterial agent in powder form white with a fruity odor for oral administration. Used to treat infectious and inflammatory diseases lower sections urinary tract. Not recommended for use by children under 12 years of age. Dispensed by prescription.

Directions for use

Side effects

Rarely appear

1. nausea,
2. vomit,
3. diarrhea,
4. skin rash that disappears on its own after discontinuation of fosfomycin.

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Release form: granules (powder) for solution (suspension).

Active ingredient: Fosfomycin, Trometamol.

Broad-spectrum antibiotic for the treatment of acute uncomplicated diseases of the genitourinary system. Also used for prophylaxis during diagnostic procedures and surgical interventions.

Directions for use

Taken orally. A single dose for adults is 3 grams, for children - 2 grams. The treatment regimen is established individually, taking into account the stage of the inflammatory process, the reactivity of the patient’s body, and the sensitivity of microorganisms to fosfomycin.

Side effects

• nausea,
• vomit,
• diarrhea,
• skin rash that disappears on its own after discontinuation of fosfomycin.

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Release form – granules for the preparation of solution for oral administration (packages) 2 grams, 3 grams.

Active ingredient: Nifuroxazide 100 milligrams, Fosfomycin.

Contains antibiotic, probiotic and fosfomycin. Used for the treatment of acute and chronic cystitis and various diseases urinary tract. Suitable for adults and children over 12 years old.

Directions for use

Used once, orally, on an empty stomach. The packet of granules should be dissolved in 100 milliliters of water and drunk. The use of the drug is possible infants only under medical supervision and in special cases.

Side effects

1. nausea,
2. vomit,
3. diarrhea,
4. skin rash that disappears on its own after discontinuation of fosfomycin.

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Description of the manual

The active ingredient of Monural is fosfomycin. The composition of the drug includes it in the form chemical compound– trometamol. Active ingredient the drug has specific action on pathogens of cystitis. Fosfomycin inhibits the synthesis of the bacterial cell wall, which disrupts the vital activity of pathogenic microorganisms and causes their death.

The drug is relatively safe, since it exhibits a rather specific effect in relation to bacterial enzymes, so there is no cross-drug resistance to it (a condition in which the resistance of pathogens to one drug also extends to related drugs).

• The drug Monural is active against most gram-positive and gram-negative bacteria.
• Its spectrum of action includes common pathogens of cystitis - coli, Klebsiella, Morganella, pathogens of sexually transmitted infections.
• The drug interferes with one of the early stages cell wall synthesis, which is why its spectrum of action is so wide.

How long does it take for Monural to work?

When taking the drug orally, the active substance is absorbed from the digestive tract within an hour. The therapeutic concentration of the drug in the blood is achieved within 2-2.5 hours, in the urine - after 4-5 hours and lasts throughout the day.

A single dose is enough to create a bactericidal concentration of the drug in the blood, so Monural for cystitis helps from the first dose. Required concentration in urine active substance maintained throughout the day (in some cases – up to 48 hours).

The drug is excreted from the body mainly through urine, only about a quarter dose taken excreted through the intestines.

Release form

1. Monural is available in the form of a powder containing white mini-granules with a characteristic fruity odor, which easily dissolve in water.
2. A solution for oral administration is prepared from the powder.
3. The drug is packaged in multilayer paper bags, laminated with polyethylene, 2 g or 3 g each and 1-2 pieces are placed in cardboard packs.

Monural powder, in addition to the main substance (fosfomycin), contains additional components– sugar, lactose, orange or tangerine flavoring, which make the drug palatable.

There is no such form of release as Monural tablets or injection solutions.

Monural - official instructions for use

Registration number P N012976/01-110707

Trade name: Monural ®

International generic name

Dosage form

granules for the preparation of a solution for oral administration.

• 1 package contains: active substance - fosfomycin trometamol 3.754 g or 5.631 g (equivalent to 2.0 g or 3.0 g fosfomycin);
• excipients: tangerine flavor, orange flavor, saccharin, sucrose.

Description

White granules with a tangerine scent.

Pharmacotherapeutic group

antibiotic

ATX code J01ХХ01.

Pharmacological properties

The active substance of Monural - fosfomycin trometamol - is a broad-spectrum antibiotic, a derivative of phosphonic acid.

Monural has a bactericidal effect. The mechanism of action is associated with the suppression of the first stage of bacterial cell wall synthesis.

Being structural analogue phosphoenol pyruvate, enters into a competitive interaction with the enzyme N-acetyl-glucosamino-3-o-enolpyruvyl transferase, resulting in specific, selective and irreversible inhibition of this enzyme, which ensures the absence of cross-resistance with other classes of antibiotics and the possibility of synergy with other antibiotics (in vitro synergism with amoxicillin, cephalexin, pipemidic acid is noted).

The antibacterial spectrum of action of fosfomycin trometamol in vitro includes most of the usual gram-positive (Enterococcus spp., Enterococcus faecalis, Staphylococcus aureus, Staphylococcus saprophyt., Staphylococcus spp.) and gram-negative (E. coli, Citrobacter spp., Enterobacter spp., Klebsiella spp., Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Pseudomonas spp., Serratia spp.) pathogens. In vitro, fosfomycin trometamol reduces the adhesion of a number of bacteria to the epithelium of the urinary tract.

Absorption: Monural is quickly absorbed from gastrointestinal tract at orally.

1. In the body it dissociates into fosfomycin and trometamol. The latter does not have antibacterial properties.
2. Bioavailability after a single oral dose of 3 g ranges from 34 to 65%.
3. The maximum plasma concentration is observed 2-2.5 hours after oral administration and is 22-32 mg/l. The half-life from plasma is 4 hours.

Distribution: Monural does not bind to plasma proteins, is not metabolized, and predominantly accumulates in the urine. When a single dose of 3 g is taken orally, a high concentration is achieved in urine (from 1053 to 4415 mg/l), 99% bactericidal for most common pathogens of urinary tract infections.

The minimum inhibitory concentration of Monural for these pathogens is 128 mg/l. It is maintained in urine for 24-48 hours, which requires a single-dose course of treatment. Concentrations of Monural in urine above the minimum inhibitory concentration for E. coli persist for at least 80 hours.

Excretion: Monural is 90% excreted unchanged by the kidneys, creating high concentrations in the urine. About 10% of the dose taken is excreted unchanged through the intestines. In patients with moderately reduced renal function (creatinine clearance

Indications for use

• Acute bacterial cystitis, acute attacks recurrent bacterial cystitis;
• bacterial nonspecific urethritis;
• asymptomatic massive bacteriuria in pregnant women;
• postoperative urinary tract infections;
• prevention of urinary tract infections during surgery and transurethral diagnostic studies.

Contraindications

Individual hypersensitivity to fosfomycin trometamol, severe renal failure (creatinine clearance)

Use during pregnancy and lactation

During pregnancy, the drug is prescribed only when potential benefit for the mother exceeds the potential risk to the fetus. If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped during treatment.

Directions for use and doses

Inside.
The granules are dissolved in 1/3 cup of water. Monural is used once a day orally on an empty stomach 2 hours before or after meals, preferably before bedtime, after emptying the bladder. Adults are prescribed 1 packet (3 g) 1 time per day.

In order to prevent urinary tract infections during surgery and transurethral diagnostic procedures, Monural is taken twice in the doses indicated above: 3 hours before the intervention and 24 hours after the intervention.

Children from 5 years to 18 years are prescribed in daily dose 2 g 1 time per day. The course of treatment is 1 day. In more severe cases (elderly patients, recurrent infections), take another 1 packet every 24 hours.

In case of renal failure, reduce the dose and lengthen the intervals between doses.

Side effect

Possible disorders of the gastrointestinal tract (nausea, heartburn, diarrhea), skin rash, allergic reactions.

Overdose

Overdose symptoms: diarrhea. If persistent diarrhea occurs, it is recommended symptomatic treatment.

The risk of overdose is minimal, since Monural is available in packages of 1 or 2 packets. In case of overdose, it is recommended to take fluids orally to increase diuresis.

Interaction with other drugs

Concomitant use with metoclopramide should be avoided, as this may lead to a decrease in the concentration of Monural in the blood serum and urine.

Special instructions

Simultaneous use food slows down the absorption of Monural - it is necessary to use the drug 2 hours before or after meals.

Patients with diabetes mellitus should take into account that 1 package of Monural with a dosage of 2 g or 3 g of fosfomycin contains 2.100 g or 2.213 g of sucrose, respectively.

Release form

Granules for preparing a solution for oral administration 2 g and 3 g. 6 g or 8 g of the drug are placed in bags of 4-layer laminated foil (paper-polyethylene-aluminum-polyethylene). 1 or 2 packets are placed in a cardboard box along with instructions for use.

Storage conditions

List B. Store at a temperature not exceeding 30 °C. Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies

According to the recipe.

Manufacturing company

Zambon Switzerland Ltd., Via Industria 13, CH-6814 Cadempino, Switzerland.

Claims regarding the quality of the drug should be sent to the following address: Representative office of Zambon Group SP.A. JSC (Italy): Russia, 121002 Moscow, Glazovsky lane, 7, office 17.

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When is Monural prescribed?

The main area of ​​application of Monural is the treatment of bacterial cystitis and urethritis (inflammation of the urethra).

Powder Monural 3g is used for acute course diseases or prescribed as part of complex treatment chronic infectious processes V urinary system. The use of the drug is also justified for acute recurrent attacks of the disease. In addition, Monural is prescribed for the following conditions:

• massive bacteriuria of pregnant women, which is asymptomatic;
• urinary tract infections in the postoperative period.

For the purpose of prevention, the drug is prescribed after surgery on the urinary tract or during therapeutic and diagnostic procedures (when placing a catheter or cytoscopy).

1. Monural is used with equal effectiveness in both women and men. Reviews of the use of Monural for cystitis show its exceptional effectiveness and fairly high safety.
2. The drug is allowed to be used at almost any age, and its use in pregnant and lactating women is also allowed, since there is no recorded negative effect of the active substance on the fetus or breastfed infant.

It is recommended to take Monural on an empty stomach, after dissolving one sachet of medication (3g) in a third of a glass of warm water. This should be done in the evening (before bed), two hours after the last meal and after emptying the bladder.

A single dose of the drug is enough to eliminate the symptoms of cystitis and destroy infectious agents.

• In case of a recurrent form of the disease, the doctor may recommend re-taking Monural a day after taking the first dose of the antibiotic.
• The same treatment regimen is used for elderly patients.
• If Monural is prescribed for prophylactic purposes, a single dose of the drug is taken 3 hours before a diagnostic procedure or surgery or one day after the intervention.

How much Monural to drink for recurrent cystitis or urethritis depends on the severity of the disease. The need to re-use the drug becomes clear one day after the first dose. If symptoms persist, you need to take another dose. You can take the drug up to three times in total.

In patients with renal failure, the treatment regimen must be adjusted - reduce the dose of the drug and increase the time interval between taking the solution. Sometimes this drug prescribed for pyelonephritis to prevent descending infection. In this case, Monural and tablets against the causative agents of the underlying disease are taken simultaneously.

There is a special release form of Monural for children, in which the dosage of the active substance is not 3, but 2 grams. The drug is used in children over 5 years of age and adolescents. The treatment regimen is the same as for adult patients - you need to dissolve a packet of powder in a third of a glass of water and drink it at night. If the drug does not help, it should not be given again.

Taking Monural during pregnancy

Exposure to any medications during pregnancy is undesirable, so the best option is to prevent diseases rather than treat them. But if a woman still gets sick, without medical supplies can't get by.

Monural – strong antibiotic, the entire course of treatment may consist of a single dose of the solution. And, although doctors say that this is better than using drugs for a week or two, women are very worried whether such a powerful effect will be harmful to the child.

The instructions for Monural indicate that it can be used during pregnancy, when the expected benefit to the mother's health is greater than possible risk for the fetus.

Many doctors agree that the drug can be prescribed during pregnancy, since no connection has been observed between taking Monural and the occurrence of pathologies of embryo development.

But still, the instructions indicate that the risk exists, albeit potential. Therefore, absolutely safe drug cannot be named. In addition, when treating with Monural during breastfeeding, it is recommended to stop it for several days so that the antibiotic does not reach the baby through the milk.

The drug cannot be unambiguously included either in the list of approved or in the list of drugs prohibited during pregnancy.

There are no reliable clinical data on the effects on the fetus. Therefore, pregnant women should not take Monural without a doctor’s prescription, based only on how they feel or based on the experience of friends.

Based on the diagnostic results, the specialist is able to assess the severity of the disease, how great the risk of complications is, and make the optimal selection medicines for the expectant mother.

Despite the lack of accurate data, today Monural is considered one of the safest antimicrobial drugs.

Advantage of Monural

Advantage of Monural over others by similar means is that the number of its techniques is minimal. During this time, it does not cause significant disturbances in the functioning of the intestines and does not have time to have a detrimental effect on the stomach.

But you need to keep in mind that the first trimester is the most dangerous period for taking any medications. The formation of basic systems and internal organs fetus, the woman’s body has not yet fully adapted to the new state, so Monural on early stages pregnancy is prohibited.

The active substance of the drug enters bloodstream, which means it can easily penetrate the placental barrier.

In the next two trimesters, the risk of any unwanted effects is minimal, but still taking Monural, you must strictly follow the instructions and observe the dosage of the drug.

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How to take Monural during pregnancy? The dosage of the drug for expectant mothers is practically no different from that for other groups of patients.

1. Adults are prescribed a single dose of a solution prepared from 1 bag of granules (3 g).
2. Repeated use after 24 hours may be required in case of severe or recurrent infection, as well as in elderly people.
3. To prevent the development of complications during surgical intervention in the urinary system and transurethral examinations, Monural is prescribed in two doses: 1 sachet 3 hours before the procedure, the other one day after the first.

Monural is used with caution to treat patients with renal failure, since excess drugs are excreted in the urine. Such patients require a reduction in the single dose and an increase in the interval between doses.

To prepare the product, stir the contents of the sachet and dissolve it in a third of a glass of water. Monural should be taken on an empty stomach, a couple of hours after a meal or the same period of time before it. It is better to drink the solution before going to bed, after emptying your bladder.

Contraindications

There are few contraindications for taking Monural. These include severe and recurrent forms of thrush, renal failure (acute and chronic), accompanied by a decrease in glomerular filtration.

Hypersensitivity to the components of the drug may also occur, in which case it is prohibited to prescribe Monural. The medicine is not intended for children under five years of age. For fungal and bacterial lesions occurring simultaneously, Monural should be prescribed together with antifungal agents so as not to worsen the patient's condition.

Adverse reactions

• Adverse reactions when taking Monural can be manifested by the appearance of skin rashes (in persons with hypersensitivity) or violations by digestive system(nausea, heartburn, vomiting or diarrhea).
• If similar symptoms are pronounced, it is advisable to replace Monural with analogues that do not cause such side effects.
• In less severe cases, to eliminate dyspepsia it is enough to increase the amount of fluid consumed.

Overdose of the drug is extremely rare. If it does occur, the patient is prescribed forced diuresis - increasing the amount of fluid consumed along with taking diuretics. There is no specific antidote; hospitalization or resuscitation measures usually does not occur.

Frequently asked questions

1. How long should I take Monural? In most cases, a single dose of the drug is sufficient. If necessary, the doctor may recommend taking the powder three times at intervals of a day (in adults). Repeated use in children is not permitted.
2. Is it possible to take Monural for thrush? If thrush is combined with bacterial cystitis, then it is possible combination treatment under the supervision of a doctor. In other cases, the use of an antibiotic may increase the manifestations of thrush.
3. Why Monural for pyelonephritis? For inflammation renal pelvis there is a risk of descending infection - the introduction of pathogens with urine flow into the bladder and urethra. To avoid this complication, the doctor may prescribe Monural.
4. Monural did not help, what should I do? Take the medicine again. If there is no improvement after re-taking the antibiotic, consult a doctor. Most often, the lack of effectiveness is explained by the fact that cystitis is of a non-bacterial nature or the infectious agents are insensitive to the active substance.
5. Does Monural help men? The drug is equally effective for cystitis, urethritis and bacteriuria in both sexes. The dosage is the same for men and women, and the method of application is the same.
6. How to use Monural in adolescents? Children's Monural can be used up to 18 years of age, that is, it can be prescribed to teenagers. In some cases, the doctor can individually select for treatment adult form drug.

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Analogues by mode of action

These drugs affect the body in a similar way as Monural.

Release form: capsules of 0.5 milligrams for oral use.

Active ingredient: Amoxicillin.

Broad-spectrum penicillin antibiotic. Available in the form of capsules (orally) and granules for suspension. Used to treat infectious diseases. Suitable for adults and children over 12 years old. The course of treatment is from 5 to 12 days.

Directions for use

Adults and children over 12 years of age take 500 milligrams 3 times a day.

Side effects

Dizziness, ataxia, allergic reactions, skin itching. skin redness, fever, rhinitis, conjunctivitis, anaphylactic shock.

Contraindications

1. Infectious mononucleosis,
2. lymphocytic leukemia,
3. severe gastrointestinal infections accompanied by diarrhea or vomiting,
4. respiratory viral infections,
5. allergic diathesis,
6. bronchial asthma,
7. hay fever,
8. hypersensitivity to penicillins and/or cephalosporins.

Nolitsin

The active ingredient of Nolitsin is Norfloxacin. It is a second generation gram-negative fluoroquinolone capable of producing high therapeutic concentrations in urine. Bactericidal activity is due to inhibition of DNA gyrase, suppression of synthesis and destabilization of DNA chains in the microbial cell.

Norfloxacin is effective against:

• staphylococci;
• gonorrhea pathogens;
• Escherichia coli;
• protea;
• Citrobacter;
• Klebsiella;
• enterobacter;
• salmonella;
• some intracellular pathogens
• hemophilus influenzae, etc.

Does not affect streptococci, enterococci, spirochetes, listeria and anaerobes, weakly effective against chlamydia and mycoplasma.

Nolitsin is produced by the Slovenian pharmaceutical company Krka.

Contraindications

1. individual intolerance to fluoroquinolones;
2. hemolytic anemia;
3. age less than eighteen years;
4. pregnancy and lactation;
5. severe cerebrovascular accidents and atherosclerosis;
6. damage to the nervous system;
7. malignant myasthenia gravis;
8. photosensitivity;
9. heart rhythm disturbances;
10. epilepsy;
11. renal or liver failure.

Undesirable effects from use

• dyspeptic disorders;
• liver dysfunction;
• allergic reactions;
• glomerulonephritis;
• antibiotic-associated diarrhea and pseudomembranous colitis;
• inflammation and tendon ruptures;
• leukopenia;
• dysbacteriosis;
• fungal infections of the oral and vaginal mucosa;
• heart rhythm disturbance;
• photosensitivity.

Long-term therapy with fluoroquinolones should be carried out under constant monitoring of coagulogram, general and biochemical analyzes blood.

Due to the pronounced increase in skin sensitivity to ultraviolet radiation, it is necessary to avoid direct exposure sun rays and use creams with high SPF protection.

Interaction with other drugs

Treatment of patients taking tableted hypoglycemic drugs should be carried out with caution, under strict control of sugar levels. This is due to the ability of Nolitsin to enhance the effect of sugar-lowering drugs.

• The simultaneous administration of fluoroquinolones and glucocorticosteroids is prohibited due to the pronounced increase in toxic effect on ligamentous apparatus. The effect of this interaction is especially pronounced in elderly patients.
• When Norfloxacin is combined with non-steroidal anti-inflammatory drugs, the neurotoxic effect may be enhanced, up to the development of seizures.
• When combined with drugs that have hypotensive effect, possible decrease blood pressure, right up to collapse.

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Urolesan

Release form: syrup in 15 ml glass bottles, in the form of tablets or capsules.

Active ingredient: Trilon-B and essential oils.

A bactericidal drug is used:

1. with stones in the bladder;
2. with stones in the gall bladder;
3. with salt diathesis;
4. with pyelonephritis in acute or chronic form;
5. with cholecystitis;
6. during inflammatory processes in the tissues of the liver and bile ducts;
7. with dyskinesia of the gallbladder.

Directions for use

Adults and children take 1 capsule or 10 milliliters of syrup, 3 times a day before meals.

Side effects

Nausea, dizziness, heartburn, diarrhea.

Contraindications

Individual intolerance to the components of the drug, stomach and intestinal ulcers, glomerulonephritis, gastritis of all forms.

Urfocin

Release form – granules for the preparation of solution for oral administration (packages) 3 grams.

Active ingredient: Fosfomycin.

Ukrainian broad-spectrum antibiotic for systemic use. Suitable for the treatment of simple urinary tract diseases. Indicated for adults and children over 12 years of age.

Directions for use

Dissolve one sachet of the drug in ⅓ glass of water. Take once a day on an empty stomach, several hours before meals, after emptying the bladder.

Use during pregnancy and lactation only under the supervision of a physician.

Side effects

• Heartburn,
• nausea,
• diarrhea,
• headache,
• skin rash.

Contraindications

Age less than 12 years, allergy to the components of the drug, renal failure, women who are breastfeeding.

Release form – paste for oral administration 100 g each in metal (aluminum) tubes.

Active ingredient: aqueous extracts from onion peel, wheatgrass root, parsley fruit, herbs bird knotweed, herbs horsetail, birch leaves, fenugreek seeds, goldenrod herb, hernia herb, lovage root.

Preparation plant origin based on hydroalcoholic herbal extracts and essential oils. Used for treatment chronic diseases urinary system.

Directions for use

Use 1 teaspoon of paste 3-4 times a day. The course of treatment is from 2 to 6 weeks.

Side effects

1. nausea,
2. diarrhea,
3. vomit,
4. skin rashes,
5. temporary loss of taste.

Contraindications

Individual intolerance, children under 15 years of age, pregnant and lactating women.

Furadonin

Release form: tablets of 100 milligrams.

Active ingredient: Nitrofurantoin.

A drug used to treat bacterial cystitis and chronic inflammation bladder.

Directions for use

Take 50-100 milligrams of the drug 3-4 times a day. You need to take the tablet with plenty of liquid.

Side effects

• Allergy,
• cough,
• dyspnea,
• itching and redness of the skin,
• drowsiness,
• headaches,
• nausea,
• loss of appetite,
• vomit.

Contraindications

Hypersensitivity to fosfomycin, predisposition to allergic reactions, with liver diseases, with renal failure, with heart failure, with arterial hypertension, with cirrhosis, with hepatitis, with lactation.

An Indian drug produced by the Ranbaxy company. The cost of a package of 20 tablets of 400 mg is about 300 rubles.

It is superior to Slovenian Norfloxacin in the quality of raw materials and lower in cost (20 tablets of Nolitsin will cost 430 rubles).

Norbactin is highly effective in the treatment of infectious and inflammatory lesions of the urinary tract of bacterial etiology, as well as prostatitis, cervicitis, endometritis, uncomplicated gonorrhea and travelers' diarrhea.

Dosages and method of administration

1. For maximum effectiveness, it is recommended to use the antibiotic 2-3 hours before meals.
2. When treating uncomplicated acute cystitis, taking 0.4 grams of Norbactin every 12 hours is indicated. The course of therapy is three days.

Treatment of infectious and inflammatory diseases of the urinary tract in acute period lasts from seven to ten days, depending on the location and severity of the disease. For frequently recurring or chronic infections The product is used for up to a month.