How to replace duphaston with folk remedies. What do we have

Name:

Duphaston

Pharmacological
action:

Dydrogesterone, which is the active substance of duphaston, - progestogen, an analogue of natural progesterone. It has no estrogenic, androgenic or corticoid effect. Does not change thermogenesis, so the presence of ovulation can be determined by monitoring basal temperature bodies. Does not affect metabolism. There are no side effects associated with the use of synthetic progestins. Effective when used internally. Selectively affects progestin receptors of the uterine mucosa. Causes normal secretory transformations in the endometrium in case of sufficient estrogen saturation. Does not affect follicle ovulation. It does not have a virilizing and/or masculinizing effect (including on the fetus).

After oral administration quickly absorbed from gastrointestinal tract. The maximum concentration in the blood after administration is observed in 2 hours. 97% of dydrogesterone binds to blood proteins. Hydroxylated in liver cells. Elimination of biotransformation products occurs in urine (56-79%). 72 hours after a single dose it is completely eliminated from the body. It does not accumulate and there is no increase in the concentration of dydrogesterone in patients with renal failure.

Indications for
application:

Confirmed endogenous progesterone deficiency(endometriosis, luteal phase deficiency, habitual fetal loss or threatened abortion, premenstrual syndrome, menstrual irregularities, amenorrhea of secondary origin, dysmenorrhea).
Substitute hormone therapy (surgical castration, including with a preserved uterus; menopausal syndrome - used when it is necessary to neutralize the proliferative effect of estrogens on the mucous membrane of the uterine cavity when using estrogens for HRT).

Directions for use:

Destination schemes are indicative. For maximum therapeutic effect, it is necessary to take into account clinical signs diseases and phases of the natural menstrual cycle. Daily dosage divided into several doses, preferably at regular intervals.

At endometriosis use 10 mg of dydrogesterone 2-3 times a day (without breaks or from the 5th to 25th day of the menstrual cycle).

At infertility progesterone genesis 20 mg/day (in 2 doses) from the 11th to 25th day of MC inclusive. The course of treatment is 3-6 months. If the patient becomes pregnant, treatment should be continued at the dose recommended for habitual loss pregnancy. The dose of dydrogesterone can be adjusted cytological examination vaginal epithelium (colpocytology).

Habitual pregnancy loss And threatened abortion– used only in case of evidence of endogenous progesterone deficiency.

In case of threatened abortion use 40 mg of dydrogesterone as a starting dose 1 time, then 10 mg every 8 hours for 1 week. After this, the dosage is gradually reduced. However, if signs of threatened abortion recur, it is possible to increase the dose again. Can be used up to 12-20 weeks of pregnancy.

With the usual miscarriage Therapy begins when planning pregnancy: 10 mg 2 times a day from the 11th to the 25th day of the menstrual cycle. If conception has occurred, therapy is carried out at the same dose continuously; from the 20th week of pregnancy, the dose is gradually reduced. Clarification of the need to increase or decrease the dosage of dydrogesterone is possible after a colpocytological study.

For premenstrual syndrome(PMS) – 10 mg from the 11th to the 25th day of the menstrual cycle. Duration of therapy – 3-6 months.

For dysmenorrhea - 20 mg/s in 2 doses from the 5th to the 25th day of the menstrual cycle, for 3-6 months.

With an irregular menstrual cycle, due to the short luteal phase, use 20 mg/day, in 2 divided doses from the 11th to the 25th day of the cycle.

In the treatment of amenorrhea used in combination with estrogens. Apply 10 mg of dydrogesterone 2 times a day from the 11th to the 25th day of the menstrual cycle while taking 0.05 ethinyl estradiol from the 1st to 25th day of the cycle. Duration of treatment – 3 or more menstrual cycles.

For dysfunctional bleeding used in a dose of 10 mg 2 times a day for 5-7 days in combination with ethinyl estradiol 0.05 mg (this regimen stops bleeding). For prophylaxis, use 10 mg of dydrogesterone 2 times per day from the 11th to 25th day of the menstrual cycle, combined with 0.05 ethinyl estradiol 1 time per day.

As HRT used only in combination with estrogens.
For continuous therapy, 10 mg is used for 14 days each menstrual cycle. When used cyclically - only in the last 12-14 days of estrogen 10 mg 1 r / s. If necessary (insufficient secretory transformations of the endometrium, confirmed by ultrasonography or histologically), the dose is increased to 20 mg/day.

Side effects:

Rarely– breakthrough bleeding. In this case, the dose of dydrogesterone must be increased. There may also be individual hypersensitivity to the drug.

Contraindications:

Undiagnosed vaginal bleeding;
- existing severe liver disease or presence serious illnesses liver in the past, if liver function tests have not returned to normal;
- the use of estrogens in combination with progestogens, such as dydrogesterone;
- established hypersensitivity to the active substance or to any other component of the drug;
- established or suspected neoplasms dependent on sex hormones.

Interaction with
other medicinal

IN lately More and more problems associated with pregnancy have begun to arise; it is becoming more difficult for women not only to become pregnant, but also to carry a child to term. Perhaps this is due to a large number abortions, or maybe our environment is to blame. To solve these problems, a remedy such as Utrozhestan, an analogue of Duphaston, is often used. Both of these drugs are hormonal, and their use often causes concern among women. So why are these drugs needed?

hormonal drugs

The drug "Duphaston" is prescribed to those women whose pregnancy is at risk of termination. Included of this medicine contains a component similar to the natural hormone progesterone, the deficiency of which can lead to miscarriage or infertility. An analogue of Duphaston, Utrozhestan, is also designed to compensate for the lack of progesterone, because if its amount in the body is normal, then pregnancy proceeds normally. Due to the “pregnancy hormone”, the placenta is formed, thanks to it, fetal rejection does not occur, pregnancy develops, the mammary glands undergo changes, and the woman’s body is actively preparing for bearing, giving birth and feeding a baby.

Description of the drug "Duphaston"

This remedy is hormonal and its action is very similar to that of natural hormone progesterone. “Duphaston” seems to replenish the missing amount of progesterone in a woman’s body. The drug is synthetic, due to which its absorption occurs in digestive tract. The medicine does not disrupt the functioning of the liver; during treatment, the woman’s blood sugar level does not change and is not disrupted. Clinical trials passed by the medicine have made it possible to achieve quite early stages use Duphaston. Reviews from doctors about it are positive, and this is not surprising, because during treatment it does not affect the development of the fetus. Reception this tool does not cause drowsiness. The Russian analogue of Duphaston cannot boast of this, since the domestic medicine Utrozhestan provides sedative effect, which means it causes drowsiness, so it is not recommended to drive after taking it.

Analogue of "Duphaston"

"Utrozhestan" (medicine) is another one that has the same purpose as "Duphaston", although there are differences between these medications significant difference. "Duphaston" is a synthetic medicine, and its "brother" contains the natural hormone progesterone, which was obtained from plant materials. The drug "Utrozhestan" is available in tablets or capsules and creates a calming effect. An analogue of the drug "Duphaston" is good to use if the body contains increased amount as this medicine can significantly reduce them negative impact. Both of these drugs do not have negative influence on ovulation and do not have contraceptive properties. The presented drugs have one contraindication - intolerance to the components of the drug, but if the patient has one, then you need to be extremely careful. Do not forget that both drugs are medications that should be used only as prescribed by the attending physician.

Effective and inexpensive analogues-substitutes Duphaston tablets

Duphaston is synthetic medical device hormonal plan, the composition of which is a complete analogue of the key female secret responsible for the process of childbirth. Many may experience its deficiency and, accordingly, infertility and other gynecological ailments of the sexual sphere. Pharmaceutical products that combat diseases of this group have impressive price tags, but on the pharmacy market there are a number of generics at a more affordable cost.

Pharmacological properties and pharmacodynamics

The active substance of the pharmaceutical product being studied is Dydrogesterone. His molecular structure, chemical and other properties almost completely coincide with the natural female hormone responsible for the processes of pregnancy and the birth of a child - progesterone.

The active component of the drug is characterized by the absence of androgenic, estrogenic, thermogenic, anabolic and glucocorticoid properties. Moreover, it does not harm the exchange nutrients, especially carbohydrates and does not inhibit liver function. He also carries out positive impact on lipid profile indicators.

In what cases is the drug used?

Indications for use:

The presence of a lack of the hormone progesterone, which prepares a woman for childbearing;
Growth of the inner layer of the walls of the uterus;
Sterility;
Threat of miscarriage;
Destabilization of menstrual cycles, their absence.

Who is not prescribed?

Use during pregnancy

Sometimes it happens that a woman cannot get pregnant, and there is also a risk of losing the child due to a lack of female hormone, which is called progesterone. It is to prevent such a tragedy that doctors often recommend an artificial substitute for this key hormone in the form of the medicine in question.

The active component is almost completely identical to the substance natural origin. When it enters a woman’s body, it is able to completely replace it. Normally, progesterone must be produced by the ovaries in conjunction with estrogen and form the uterine lining, which definitely changes during the monthly cycles.

During menstruation, progesterone is not expressed in the blood as much as estrogen, which helps uterine cells multiply and grow. In the days when a mature egg is released from the ovaries, a temporary gland is formed that is responsible for the production of progesterone, called the corpus luteum. A change in the concentration of this hormone can change the uterine mucosa, giving it looseness, which prevents cell growth and promotes the appearance of a number of blood vessels. This process is very important when fertilizing an egg, so that it can receive the most important nutrition for it.

That is why Duphaston is prescribed to women who fail to become mothers.

Drug absorption

The use of this pharmaceutical product can provoke some associated negative phenomena:

Hematopoiesis: pathologies affecting red blood cells, namely a shortening of their life cycle;
Immune system and skin: reactions hypersensitivity in the form of rash and urticaria;
Central nervous system: headaches;
Reproductive system: bleeding from the uterus.

How to carry out the healing process?

The prescribed dosage of the medication directly depends on the existing disease:

Presence of proliferation of uterine tissue - 10 mg from days 5 to 25 of the cycle 2 to 3 times a day;
Decline negative impacts PMS – 10 mg twice a day from 11 to 25 days of the cycle;
Stopping bleeding - 10 mg per day for a week;
Infertility – 10 mg from days 14 to 25 of the menstrual cycle. The duration of therapy should be at least 3 months and no more than six months;
Preventing premature births – a single dose of 40 mg of the drug. After that - 10 mg every eight hours;
Normalization of menstruation - 10 mg from days 11 to 25 of the cycle.

Consequences of excessive dosage

There are no data on overdose symptoms. If the dose is extremely large, it is recommended to perform gastric lavage.

Important points in therapy

Some patients may experience breakthrough bleeding. They can be eliminated by increasing the dosage of the medication;
Before carrying out the treatment process, in mandatory it is necessary to go through in-depth medical examination, including examination by a qualified gynecologist and mammologist;
The drug is allowed to be taken by managers of vehicles and other units, as it does not have an adverse effect on the speed of decision-making.

How much does Duphaston cost: price at the pharmacy

The medication can be purchased at the nearest pharmacy, but a doctor's prescription will be required. According to information from one of the largest websites selling pharmaceuticals, the cost of a pharmaceutical product can reach up to 737 rubles.

List of Russian and foreign similar medical products at low cost

Progesterone – (manufactured in Russia)

Indicated in the presence of uterine hemorrhages, absence of regular menstruation and spontaneous abortion.

Not used in patients with severe hepatic and renal dysfunction, thromboembolic diseases, vaginal bleeding of unknown origin, oncological lesion epithelial cells skin mammary glands. IN extreme cases and only after consulting a doctor is it possible to use the medication. Heart patients need to be especially careful vascular diseases, diabetes, asthma and epilepsy.

Possible increase as a side effect blood pressure, which is the most common occurrence. Quite rarely, vomiting, decreased libido, a feeling of chest tightness, headaches and depression can occur.

Utrozhestan – (Thailand)

Allowed for both oral and intravaginal use. In the first case, the medicine can prevent the risk of miscarriage, infertility, prevent the development of premenstrual syndromes and treat breast cysts. When inserted into the vagina, Utrozhestan is recommended for ovarian dysfunction, premature menopause and those who may give birth prematurely.

It is prohibited for those who cannot tolerate the constituent components of a pharmaceutical product, have thrombotic diseases, bleeding from the vagina of unknown origin, oncology of the liver, breast and genital organs, as well as minors and those in their period. breastfeeding. The medical product is not recommended for latest dates pregnancy.

At the same time, malfunctions of the reproductive system, problems with stable menstrual cycle. Sometimes there are pains in the head, a craving for sleep and skin rashes with itching.

Iprogine – (France)

Like the previous generic, this one French drug can be taken orally or inserted into the vagina. In both cases, Iprozhin effectively copes with syndromes that occur before menstruation, fibrocystic mastopathy. It is within his competence to prevent endocrine infertility, premature birth and development benign tumors uterus.

You should stop taking the medicine if you do not absorb its constituent substances, if there are unclear reasons for the release of blood from the reproductive organ, malignant formations in the reproductive system and mammary glands. Patients with severe heart failure, kidney failure, asthma, epilepsy and diabetes need to be especially careful. In addition, therapy during the lactation period is not recommended.

Side effects occur infrequently. The most possible are minor allergies, a feeling of fatigue and a desire to go to sleep, temporary dizziness and an unstable menstrual cycle.

Prajisan - (the most affordable substitute made in India)

Despite the significantly distinguished low cost, provides effective treatment female infertility, which is caused by luteal insufficiency, facilitates the premenstrual period and helps stabilize the cycle. Thus, by paying little money, you can get a similar pharmaceutical effect.

Contraindications are completely identical to all medications discussed above.

Parallel reactions of a harmful nature occur extremely rarely. Provoke tension in the mammary glands, excessive desire for sleep, periodic vestibular disorders, nausea and skin rash, can only be a long process of treatment.

Conclusion on low-cost generics

A studied European medicinal product that has a positive effect on reproductive system representatives of the fair sex. On Russian market, without special problems you can choose a similar substitute - many companies and pharmaceutical manufacturers (mostly foreign) are producing synonyms that are affordable in economic terms. At first glance, it may seem that choosing a substitute is not such a big deal. difficult task. However, the decision on this issue should be delegated to a qualified doctor. It is he who must prescribe a certain drug.

The modern pharmacological market offers many various medications. Some of them are interchangeable, there are analogues and generics. If we are talking about a drug like Duphaston, then there are several analogues. It is only important to understand the basic principles of action of each drug and understand the difference.

Duphaston and its analogues

All analogues of Duphaston, like the original drug itself, contain synthetic progesterone, a hormone that is responsible for the course of pregnancy.

They are used for following states observed in women:

menstrual irregularities;
bleeding in the uterus;
acute PMS;
infertility, which occurs due to luteal insufficiency;
endometriosis;
menopause and menopausal syndrome;
mastopathy of the mammary glands.

It is also often prescribed to pregnant women who are found to be at risk of miscarriage. Progesterone contributes to the normal course of pregnancy.

It creates conditions for normal education ovum, reliable attachment to the wall of the uterus, its nutrition, and also prevents miscarriages during the first trimester, when hormonal background still unstable. With a lack of progesterone, the body cannot react correctly to the appearance of the fetus, perceives it as a foreign object and rejects it. It is for this reason that frequent miscarriages occur during the first three months of pregnancy.

Duphaston and its analogues are as close as possible in their structure to hormones that naturally are produced by the female body, as a result of which progesterone is absorbed most efficiently when internal reception drug. The most important advantage of such funds is their origin. Unlike most synthetic hormones, the substances contained in the drug are not derivatives of testosterone, which eliminates the occurrence of many side effects:

liver dysfunction;
blood clotting disorder;
manifestation female characteristics in a male fetus;
manifestation male characteristics in female fetuses;
change in glucose concentration;
negative impact on the internal secretion organs.

Duphaston has virtually no contraindications. The only reason why a drug can be excluded is individual intolerance some components, that is, allergies. In order to determine whether this remedy is suitable for treatment or not, it is necessary to undergo mandatory inspection and consult with experienced specialist. It has successfully proven itself in modern gynecology and is widely used for the treatment and prevention of many conditions.

Choosing the right product

Duphaston is an expensive drug that must be taken for long period time. Often, such expenses can become unaffordable for future parents. However, pharmacology offers many replacement options, since there are drugs on the market with similar composition or pharmacological action. So what can replace Duphaston and what criteria should you use when choosing?

The most important indicator when choosing an analogue, it is not the price (although it plays a big role), but therapeutic effect means. Indications for use and the list of conditions for which the medicine is used should be as identical as possible. The products do not have to be completely identical when it comes to composition. Some drugs may have the same active ingredients, be similar to it, or differ completely in composition, but have an almost identical effect on the body. Therefore, all analogues can be divided into two main groups:

identical;
drugs with similar effects.

It is very important to understand that before changing the drug, you need to consult with your doctor, who will not only help you choose suitable remedy, but will also be able to guarantee its maximum effectiveness in each individual case. This is due to the characteristics of the organism to which different drugs can provide different action.

Identical composition

The composition and, therefore, all therapeutic characteristics of the two drugs are completely identical: Duphaston and Dydrogesterone. They can replace Duphaston without any harm to the body. However, despite the identical active ingredient, they have some differences, which you need to be aware of before taking each of the described remedies.

1. Duphaston.

Duphaston is a generic drug known drug. As you know, the generic is completely identical medicine, which has a different name because the original was developed by another company that patented it. Duphaston was released differently pharmaceutical company, but its composition is completely identical to its predecessor. The only difference is the price, which can be either higher or lower, depending on the pharmacy chain, place of sale and country of manufacture.

2. Dydrogesterone.

Dydrogesterone, in turn, has a slightly different composition, but has an absolutely identical effect. Its only component is the substance of the same name, which is also the main component of Duphaston - synthetic progesterone. The additional ingredients indicated in the composition are necessary only to create the dosage form and do not in any way affect the action of the medicine. Since production requires minimum costs, then the cost of Dydrogesterone is an order of magnitude lower than that of other products in this series. The main difficulty in its use is its relative rarity on sale. It is produced in limited quantities and rarely appears in pharmacies. This issue is especially acute for regional pharmacies in remote cities, as well as cities with small populations.

Similar action

The second group of drugs includes drugs that have a different composition, but have the same therapeutic characteristics and testimony that Duphaston. They can be used to treat the same diseases for which the original drug is intended, but they are also slightly different. To fully replace one drug with another, you need to consult a specialist.

1. Utrozhestan.

The most popular and well-known analogue is considered to be a drug developed in Thailand, known as Utrozhestan. The main component is natural micronized progesterone. It was obtained with the participation of volunteers and also synthesized with the help of animals. Widespread he received it precisely thanks to naturalness active substance, which practically does not cause allergic reactions, unlike artificially created hormone substitutes. Despite all the positive aspects, Utrozhestan has some negative ones side effects and has contraindications:

often provokes headaches and migraines;
may cause itching, hives, allergic reactions, up to Quincke's edema;
causes increased fatigue, drowsiness and decreased performance;
contraindicated for women who are engaged in active activities;
it is prohibited for women who drive vehicles;
prohibited for use by women who experience bleeding in the birth canal.

That is why the use of Utrozhestan should be agreed with a doctor and prescribed only after an examination and tests that exclude the possibility of manifestations negative consequences from using the drug. The most important test is to check for allergic reactions and intolerance to the components of the drug.

It is produced in two dosage forms: in the form of tablets, as well as suppositories, which are used intravaginally.

It is Utrozhestan that is considered the most a worthy replacement Duphaston.

It is most similar to natural hormones, which are produced in the female body, and promote pregnancy, and also fully prepare the endometrium, creating favorable conditions for egg implantation and successful pregnancy early stages. TO positive aspects This remedy can be attributed to the fact that it does not promote weight gain, does not retain fluid in the body, and does not affect blood pressure and metabolic processes.

2. Progesterone.

Preparation Russian production Progesterone has the same effect on female body, as Duphaston. Moreover, its main active ingredient is gestagen, which is also known as a hormone corpus luteum. The main difference between the two tools is dosage form. Duphaston is available in tablet form, Progesterone is available only in injection form. Most often it is used for inpatient treatment in hospitals, because independent use can be quite problematic. Its form also allows you to accelerate the effect of the drug on the body, which makes it indispensable in treatment severe forms spontaneous abortion.

The main reason for replacing Duphaston with any of its analogues is cost original drug. Almost all analogs have a price several times lower, which makes them accessible to everyone. Most often, the price is determined by the country of origin, the company that launched the product on the market, and also official representative and a network of pharmacies that sell and set their own price for the medicine.

During pregnancy it is especially important to maintain normal level the hormone progesterone. Due to insufficient natural production, Duphaston is indicated.

In addition, a drug based on the active substance dydrogesterone helps in the treatment of infertility and other hormonal disorders.

An indispensable female assistant can be bought at a pharmacy for 600 rubles. However, the minimum duration of treatment is a month, which puts a strain on the family budget.

Read what cheap analogues of Duphaston Russian and foreign production.

Russian-made analogues

Domestic pharmacological companies cannot offer cheap substitutes. But on the shelves of pharmacies there are Russian-made analogues that are cheaper than the original.

Practical medicines do not differ in composition: they are based active substance– dydrogesterone.

Check out the best inexpensive analogues in the table:

Substitute name	Description and indications for use of the generic	Average cost in a pharmacy
Progesterone	A synthetic substitute for the hormone of the same name. Unlike the tablet form of Duphaston, Russian analogue Available in the form of a solution for intravenous administration. The cost differs by only 20 rubles	580 rubles
Dydrogesterone	A drug containing the same substance. Like the original, it is indicated for maintaining pregnancy, in the treatment of infertility and for normalizing the menstrual cycle	480 rubles
Pregnin	A similar substitute in composition, which also supports the vital activity of the fetus in the uterus, preventing an incipient miscarriage. Often indicated for use to increase lactation. Release form - tablets	450 rubles

Buying Progesterone will be profitable for only 20 rubles. Pregnin can be purchased for 450 rubles, which helps save 300 from two packages.

The drug is indicated during pregnancy and lactation only strict indications doctor

Ukrainian generics

Among gestagens you can find cheap generics. The Ukrainian manufacturer offers to buy packaging from 100 rubles.

What determines this cost and how long the effect lasts after taking the drug, read on.

Check out the list of the cheapest synonyms of Ukrainian production:

The undoubted advantage of Ukrainian substitutes is their affordability. You can purchase the drug Inzhesta for only 100 rubles.

Of all the listed drugs, folliculin has a different composition, but it has a similar effect.

The disadvantage of Ukrainian synonyms is that they are rarely available in pharmacies in Russia.

Other foreign substitutes

Imported products are considered expensive, but of high quality. But among the many pharmaceutical substitutes, you can find cheaper medications.

Foreign-made generics can be purchased from 300 rubles per package.

Among the most popular drugs:

Duphaston, like its analogues, is indicated for long-term use. Depending on the problem, the doctor prescribes a specific treatment regimen.

After discontinuation of the drug, the effect persists for several more days. You can purchase synonyms of foreign production in the range from 300 to 600 rubles.

Attention. Before use, consult a gynecologist or obstetrician about the advisability of replacing Duphaston with a cheaper analogue.