Clotrimazole or pimafucin which is better. Pimafucin or clotrimazole for thrush, which is better?
Photo of the drug
The description is valid on 05.06.2014
- Latin name: Pimafucin
- ATX code: A07AA03
- Active substance: Natamycin
- Manufacturer: Temmler Italia, S.r.L, Italy
Compound
Part candles included as an active component. Additional components include: cetyl alcohol , adipic acid , hard fat, sorbitan trioleate , polysorbate 80, sodium bicarbonate.
Pifamucin ointment. Main component – natamycin . Auxiliary components: propylene glycol, cetostearic alcohol, sodium lauryl sulfate, purified water, decyl letate, methyl parahydroxybenzoate, cetyl wax ether, propyl parahydroxybenzoate.
Pifamucin tablets. The active ingredient in tablets is natamycin , auxiliary ingredients: kaolin, white beeswax, titanium dioxide, sucrose, magnesium stearate, kaolin, methyl parahydroxybenzoate, gelatin, gum arabic, potato starch, lactose, triacetin.
Release form
The drug is available in three forms: tablets, cream and vaginal suppositories for thrush. White round tablets are available in dark glass bottles of 20 pcs. The cream has a white or light yellow color, is produced in aluminum or plastic tubes of 30 g. Suppositories are produced in foil strips, which contain 3 suppositories; the package can contain 1 or 2 strips.
pharmachologic effect
Pimafucin has antifungal And fungicidal effect .
Pharmacodynamics and pharmacokinetics
The principle of action of the drug is based on the binding of sterols in the cell membrane, violating their integrity, which causes the death of the microorganism. The drug affects yeast-like mushrooms (especially on Candida albicans), yeast , dermatophytes , pathogenic fungi .
Natamycin is active when used topically, has no systemic effect, and is not absorbed through mucous membranes or skin. The enteric coating of the tablets determines the effect of the drug in the intestines.
Indications for use
Pimafucin cream prescribed for fungal infections nail plates, skin and With lysoid membranes, including vulvovaginitis , balanoposthitis , vulvitis , ringworm , otitis caused by fungi or complicated by candidiasis, nails , skin .
Pimafucin tablets effective for fungal diseases external auditory canal, mucous membranes, oral cavity. It is prescribed for intestinal candidiasis , after therapy corticosteroids , antibiotics , cytostatics , vulvovaginitis , vulvitis , vaginitis , acute atrophic or pseudomembranous candidiasis With cachexia .
Pimafucin suppositories prescribed for balanoposthitis , vulvovaginitis , vulvitis , vaginitis caused by Candida fungi.
Contraindications
In case of hypersensitivity to the substances included in Pimafucin, taking the drug is contraindicated.
Side effects
Tablets at the beginning of therapy may cause nausea or, during further treatment, these symptoms disappear spontaneously.
When applied topically (suppositories or cream), mild skin irritation or burning .
Instructions for use of Pimafucin (Method and dosage)
Pimafucin suppositories, instructions for use. Used intravaginally. At vulvovaginitis , vulvitis And vaginitis 1 suppository is administered for 3-6 days. It is necessary to enter in the position “ lying down", as deeply as possible, before bedtime, once a day. If treatment caused Candida albicans vaginitis does not help, then you should take tablets - 10-20 days, 1 tablet four times a day. For men, use cream during treatment. The duration of treatment is determined in each case individually. After the symptoms of the disease disappear, treatment should be continued for several more days.
Instructions for the cream. For external use. The ointment should be applied to the affected areas one to several times a day. balanoposthitis , vulvovaginitis And vulvitis . If symptoms persist, suppositories or tablets are prescribed. At dermatomycosis (including diaper rash in children and candidiasis of the nails and skin) the suspension should be applied to the nails and skin up to 4 times a day.
In case of external auditory canal, the affected area should be lubricated with cream up to four times a day, having first cleaned the ear. After use, it is necessary to place a turunda made of cotton or wool into the ear canal. The duration of treatment is determined individually. After the symptoms completely disappear, it is necessary to continue treatment for several days.
Instructions for use of tablets. Adults with intestinal candidiasis Prescribe 1 tablet four times a day, for children - 1 tablet twice a day. On average, the course of treatment lasts a week.
Overdose
There are currently no known cases of overdose.
Interaction
Not described.
Terms of sale
Sale without a prescription is allowed.
Storage conditions
At a temperature of about 25 °C.
Best before date
24 months.
special instructions
Under the influence of body temperature, vaginal suppositories quickly dissolve, forming a foamy mass, due to which the active substance is distributed evenly. For recurrent or chronic infections, therapy can be supplemented with cream or tablets.
Cetyl alcohol, which is part of the suppositories, can cause a burning sensation in the genital area. Candle therapy should be interrupted during menstruation. During treatment with suppositories, sexual intercourse may not be excluded. However, both partners should be examined, and if a lesion is detected, Pimafucin cream for men should be used. Treatment with ointment for men occurs in the manner prescribed by the instructions. When having sexual intercourse during treatment, barrier contraceptives should be used.
It is possible to prescribe Pimafucin to newborns.
Pimafucin's analogs
Level 4 ATX code matches:Analogs of tablets: drugs and Nystatin-Health .
Analogues in the form of suppositories: , . The price of analog candles is from 37 to 320 rubles.
Pimafucin has a cheaper analogue — Nystatin , a domestically produced drug, similar in action.
Clotrimazole or Pimafucin - which is better?
Clotrimazole is available in the form of suppositories and cream. The course of treatment usually lasts about a week, the drug is well tolerated, which reduces the risk of side effects to a minimum. However, it may cause allergic reactions to any of its components. If the disease is detected in a woman, thrush ointment for men is used. According to experts, Pimafucin is more effective when used topically and it almost does not enter the systemic bloodstream. Therefore, it can also be used to treat pregnant women.
Which is better: Terzhinan or Pimafucin?
Produced in the form of vaginal tablets, it can be prescribed not only in the presence of the disease, but also for its prevention. The average duration of drug treatment is 10 days. It is also easily tolerated and can be used before childbirth.
With alcohol
Alcohol in combination with Pimafucin can lead to consequences undesirable for the body. It is strictly forbidden to drink alcoholic beverages if you have intestinal candidiasis. Alcoholic drinks lead to an exacerbation of fungal diseases, which can cause prolongation of treatment or its ineffectiveness.
Pimafucin during pregnancy and lactation
There are no contraindications for taking the drug for pregnant women or while breastfeeding. Tablets and cream are used both in the early stages of pregnancy and in later stages. Most often, Pimafucin suppositories are prescribed during pregnancy, rather than other forms of this medicine. The drug is non-toxic and safe for the fetus both during the 1st trimester and 2nd trimester, as well as during lactation. However, to minimize the risk, it is better to take suppositories during lactation, or cream. Use of the drug is as indicated in the instructions.
Reviews of Pimafucin
On the forums, the overwhelming majority of patients report a positive effect after using the medicine. However, there are cases when there is no improvement in the condition or it even worsens. There are also claims about the short-term effect of treatment for thrush and other diseases.
Pifamucin from, according to patients, helps by quickly eliminating its symptoms. Moreover, the cream is effective for both women and men. Pimafucin tablets for thrush also help in the treatment and prevention of candidiasis.
Reviews about the tablets are most often good; patients write about the fast and effective action of the medicine and the complete absence of side effects. Reviews of Pimafucin suppositories for thrush report that they relieve itching faster than when taking tablets, as they act locally. There are no negative reviews about Pimafucin cream; it helps well with fungal diseases and is easily tolerated. Most often, the ointment is prescribed to men. Positive reviews during pregnancy note that the drug does not affect the development of the fetus and is very well tolerated, quickly eliminating the disease.
Pimafucin price, where to buy
Price Pimafucin cream is 87 UAH in Ukraine, in particular in Kharkov the ointment costs about 81 UAH.
In Russia price Pimafucin tablets– 360 rubles, in Belarus the cost of medicine in tablets is 133.5 thousand rubles.
Price Pimafucin suppositories for thrush - 270-380 rubles. In Odessa, candles No. 3 cost 123 UAH, candles No. 6 – 213 UAH.
You can find out how much the suppositories cost and buy other forms of the drug directly at the pharmacy.
- Online pharmacies in Russia Russia
- Online pharmacies in Ukraine Ukraine
- Online pharmacies in Kazakhstan Kazakhstan
ZdravCity
Pimafucin supp. vag. 100mg n3Temmler Italia S.r.L.
Pimafucin cream 2% 30gTemmler Italia/Astellas
Pimafucin tab. p.o ksh/sol 100 mg n20Astellas Pharma Europe B.V.
Pharmacy Dialog
Pimafucin cream (tube 30g)
Pimafucin (100 mg tablet No. 20)
Pimafucin vaginal suppositories 100 mg No. 6
Pimafucin vaginal suppositories 100 mg No. 3
Europharm * 4% discount using promo code medside11
Pimafucin vaginal suppositories 100 mg n6Temmler Italia S.r.L.
Pimafucin cream 30 gTemmler Italia/Astellas
Pimafucin tablets 100 mg n20Astellas Pharma Europe B.V.
Pimafucin vaginal suppositories 100 mg n3 Temmler S.r. L.
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Pharmacy24
Pimafucin 100 mg No. 3 vaginal suppositoriesTemmler Italy S.r.l., Italy
Pimafucin 100 mg No. 6 suppositoriesTemmler Italy S.r.l., Italy
Pimafucin 2% 30 g creamTemmler Italy S.r.l., Italy
Pimafucin 100 mg N20 tabletsAstellas Pharma Europe B.V., Netherlands
PaniPharmacy
Pimafucin suppository Pimafucin vaginal suppositories 100 mg No. 6 Italy, Temmler Italia
Pimafucin tablets Pimafucin film-coated tablets 100 mg No. 20Netherlands, Astellas Pharma Europe
Pimafucin cream Pimafucin cream 2% 30g No. 1 Italy, Temmler Italia
Pimafucin suppository Pimafucin vaginal suppositories 100 mg N3 Italy, Temmler Italia
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Education: Graduated from Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.
Experience: From 2003 to 2013, she worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.
Note!
Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Pimafucin, be sure to consult with your doctor.Reviews
The candles helped with a bright outbreak of thrush. I have never had it as abundant and burning as this time. The doctor prescribed Pimafucin, and that’s what they decided on. Candles are what you need! Help arrived the next day, and the discharge also quickly disappeared. So for those who care about getting rid of thrush quickly and without unnecessary incidents, then this is pimafucin.
I was treating thrush with a friend, and it just so happened that we encountered the same problem at the same time. Pimafucin helped both and in the same time frame, which suggests that it works flawlessly. It’s not for nothing that gynecologists praise and prescribe it, because the composition is good, the body reacts as it should. There was no trace of thrush left after a couple of days, but we completed the entire course, i.e. 6.
It didn't help my thrush. I even gave him a second chance, but still no results. As there were discharges, they continued. Only Zalain helped me in the end, but I didn’t even count on recovery.
In the first trimester, SUCH thrush began that there are simply no words! And nothing is impossible, the most crucial period... fortunately, my doctor is experienced, she reassured me and told me that pimafucin can be used at any time. That they say the candles are completely safe, but at the same time their effectiveness is high. I put 6 pieces in and am able to continue my pregnancy without thrush.
There were problems with the intestines and frequent thrush - I never connected these two phenomena, but in vain. It turned out that the cause of the disease was the same - common - candidiasis lives on almost any mucous membrane, so the treatment was suppositories and tablets. Everything went pretty quickly, the course was only 2 weeks. Results for a year already! Pimafucin simply saved the situation, otherwise it seemed that after 30 I began to fall apart and constantly get sick.
Oh, I don’t know, the hyped drug didn’t help me at all(
I liked pimafucin for its action. Somehow, the body immediately realized that the treatment was working and the thrush began to recede. I treated this problem for the 2nd time in my life, and I will say that pimafucin is many times more powerful than fluconazole. Ask for the right suppositories at the pharmacy and thrush will have no chance.
Yes, this is a normal treatment for thrush. I bought cream and suppositories, the irritation on my skin was too severe. Everything helped quickly - the itching, irritation, and discharge - everything went away. I heard that you can treat it this way even during pregnancy, the composition is safe, which again is a bonus.
My husband was prescribed Pimafucin cream for balonoposthitis. I immediately noticed the name because I was treated with the same suppositories. It turned out that in both cases it is thrush, it’s just called and manifested differently. I didn’t know that it is easily transmitted from woman to man and vice versa. Both were treated and the problem went away on its own.
15 April 2019, 20:24
I had to get acquainted with the cream when thrush went beyond the usual limits, so to speak. Irritation also appeared on the skin, then the doctor said to take not only suppositories, but also cream. It’s clear how the candles worked, how the creams worked. Indeed, all this made my life easier and shortened the duration of treatment with severe symptoms. Thrush is definitely not a “pleasure” that you want to prolong.
Anyone who has ever struggled with thrush knows that the most important thing is not just to calm the body, but also to ensure that it does not recur. This is the most difficult thing. I was lucky with pimafucin; the doctor immediately told me to take it. 6 candles and that’s it, the thrush with all its manifestations disappeared. And everything according to the analyzes is good and clean. No problem.
I used cream and candles. Pimafucin surprised me with its speed of action and good tolerability. I am sensitive and allergic to a lot of things, but here everything was completely fine. The thrush was fierce, but quickly curled up when help arrived in the form of pimafucin. It was not in vain that the doctor prescribed it to me, not in vain.
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Suppositories for thrush are the most convenient way of local treatment of vaginal candidiasis in women. The effect of vaginal suppositories is due to the deep penetration of the active antifungal substance into the mucous membrane, which destroys the pathogen, eliminates inflammation, and reduces inflammation.
The pharmaceutical industry offers a wide range of different ones - these are both suppositories for local treatment and medications for oral administration, which are prescribed by a doctor for severe forms of candidiasis, for chronic thrush as part of complex therapy.
Which suppositories are best for thrush? There is one answer to this question - these are those drugs to which the candida fungus is sensitive based on the result of bacterial culture and determination of the resistance, resistance or sensitivity of the pathogen to a specific drug. Because in chronic, often relapsing cases, it may not be effective due to the development of drug resistance in fungal agents.
Uncontrolled, independent treatment of thrush leads to both the development of chronic candidiasis and disruption of the vaginal microflora. Moreover, many women actively practice this, which is not acceptable, since it only provokes further progression of the disease, further disrupting the vaginal microflora. Only the attending physician, based on the patient’s medical history, clinical picture, and taking into account the sensitivity of the pathogen, prescribes an adequate treatment regimen. Even if symptoms disappear, clinical recovery is considered to be the absence of fungi according to laboratory data over the next 3 months.
Rules for using suppositories against thrush
In the absence of therapy with a regular partner, a ping-pong effect occurs when a woman, after treatment, is again subjected to a fungal attack during unprotected sexual intercourse.
During therapy, you should either abstain from sexual intercourse or use condoms. Suppositories are inserted deep into the vagina at night to improve absorption of the drug.
When a woman is diagnosed with vaginal candidiasis, she and her doctor should analyze it, since without eliminating or minimizing the provoking factors, thrush can occur again and again.
Very often, candidiasis indicates the presence of other sexually transmitted infections (mycoplasmosis, gonorrhea, trichomoniasis, etc.) as well as the development of gardnerellosis ().
Depending on the intensity of the symptoms, acute or chronic process, treatment may differ in the course of therapy, in some cases it is enough to use 1 suppository, but in case of a chronic process this is not enough and longer treatment is required.
- Vaginal suppositories should not be used during menstruation, with the exception of Povidone-Iodine (Iodoxide, Betadine) and Sertaconazole (Zalain).
- The following suppositories can be used for 1 suppository: Zalain, Lomexin
- 3 suppositories each - Livarol, Gino-pevaril, Pimafucin.
- 5-14 suppositories each - Macmiror, Clotrimazole, Ginezol, Iodoxide, Nystatin, Polygynax, Terzhinan, Irunin.
During treatment, you should not wear synthetic, tight-fitting underwear, you must follow all the rules of intimate hygiene, change towels and linen daily, do not use chemicalized, scented pads, toilet paper, or intimate hygiene fluids, which only worsen the condition.
The best suppositories for thrush - Livarol, Pimafucin, Zalain, Nystatin, Clotrimazole, Lomixin, Macmiror - pros and cons of use
Sertaconazole - ZalainZalain(price 1 soup. 480-520 rubles, prices 2018) It is a derivative of benzothiophene and imidazole. Use during pregnancy: There is no sufficient data on the potential harm to the fetus during breastfeeding. But given the one-time method of use and the lack of systemic action of Zalain - during pregnancy, lactation, it is possible to use it in a situation where the expected benefit for the woman is higher than the possible risk for the child. |
Ketoconazole - Livarol
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Itraconazole - Irunin
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Nystatin + Nifuratel
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Contraindications: increased sensitivity, it is strictly forbidden to use in the 1st trimester of pregnancy, while breastfeeding |
Miconazole - Klion D, Neo-Penotran
|
Econazole
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Natamycin - Pimafucin Effect on the fetus: approved for use during pregnancy |
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Contraindications: pregnancy of any stage, individual sensitivity |
Povidone-iodine - Iodoxide
Contraindications: thyrotoxicosis, thyroid adenoma, with caution in case of renal failure, in case of individual sensitivity, not recommended during pregnancy, contraindicated in the 1st trimester, in the 2-3rd trimester and during lactation - with caution. |
Fenticonazole - Lomexin
Contraindications: pregnancy, cannot be used during menstruation, if you are hypersensitive to the components of the suppository. |
Dequalinium chloride - Fluomizin
|
(30-60 rubles) 
(10 pcs. 300 rub.), Betadine(price 7 pcs. 400 rub., 14 pcs. 500 rub.)
(fenticonazole, price 1000 mg. 1 piece 400 rub. 600 mg. 2 pieces 600 rub.)
In addition to suppositories, it is possible to use creams with antifungal drugs:
- Clotrimazole - Candide (with applicator 80 rubles), Clotrimazole cream 120 rubles, Kanizon 80 rubles.
- Econazole – Ecodax cream 140 RUR
- Isoconazole - Travogen cream 500-700 rub.
- Fenticonazole - Lomexin cream 600 rub.
- Butoconazole - Gynofort cream with applicator 600-700 rub.
For chronic recurrent thrush, it is necessary to take antifungal drugs orally:
- Fluconazole 40-50 rubles (and more expensive analogues Flucostat, Mikomax, Mikosist, Diflucan)
- Tinidazole 30-70 rub.
- Ketoconazole – Mycozoral 460 RUR
- Itraconazole - Irunin 320 rubles, Itrazol 380 rubles, Orungamin.
After antifungal therapy, the doctor may prescribe medications to normalize the vaginal microflora, that is, create conditions for the growth of lactobacilli in the vagina:
- Vagilak 2 times a day (suppositories with bifidobacteria) for 5-10 days.
- Laktozhinal, Acylact (lactobacteria) vaginal capsules for 1-10 days.
- For oral administration - Bificol 10 days.
Advantages and disadvantages of using suppositories for thrush
Advantages of using topical medications for candidiasis in women:
- When the drug is administered to a place where fungi actively multiply, the effect of local treatment appears much faster, especially when using modern effective drugs such as Livarol or Zalain.
- Modern antifungal agents can be used once.
- Because systemic absorption of topical medications is low, the incidence of side effects is reduced, unlike oral therapy.
Disadvantages of local treatment:
- Local treatment causes some inconvenience to a woman - it stains her underwear and limits her sex life.
- A positive effect from such therapy is possible only in mild forms of thrush, but when the course of the disease is more severe and prolonged, local therapy should be supplemented with the use of. Therefore, it is often necessary to repeat the course of treatment after a certain time.
- When using combined antimicrobial drugs, such as Terzhinan, Polygynax, a common side effect is vaginal dysbiosis, which then requires additional treatment, for example, the use of suppositories with lactobacilli - Lactonorma, Acylact, Lactobacterin, Ecofemin or Vagiflora.
Suppositories for thrush during pregnancy
Very often, thrush occurs in women during pregnancy due to a physiological decrease in immunity, and many drugs either categorically cannot be used, or reliable studies of safety for the fetus have not been carried out. Among the entire selection of local drugs, the following suppositories are approved for use:
- Suppositories - Pimafucin, Primafungin (active ingredient Natamycin).
- Combined drug - Macmiror complex (active ingredients Nystatin and Nifuratel).
- Some doctors prescribe a combination drug - Terzhinan (prednisolone, neomycin, ternidazole, nystatin), but the instructions for it indicate that from the 2nd trimester it can only be used when assessing the potential benefit to the mother and harm to the fetus, since it has undesirable side effects and contains a hormonal drug - prednisolone.
In the 2-3 trimesters Clotrimazole, Nystatin (low effectiveness) or the ancient remedy Borax in glycerin (Sodium tetraborate in glycerin), Pimafucin, Gino-Pevaril, Ginofort (vaginal cream), all these drugs are used during pregnancy with caution if there is a potential risk for the health of the mother exceeds the risk for the child.
For vaginosis, which is caused by the yeast-like fungus Candida, doctors usually prescribe the drugs Clotrimazole or Pimafucin. Doctors consider them the most effective in this situation. But in order to determine what is more effective, it is necessary to study in detail the composition of each drug, as well as the spectrum of action and other features. What is better, “Pimafucin” or “Clotrimazole” for thrush?
Properties
The effectiveness of therapy with one or another medication depends on the characteristics of the body and the severity of the fungal infection. What is "Pimafucin" from?
Fungi can appear in large quantities in the body, which sometimes exceeds the permissible level. It is difficult to cope with this without pharmacological treatment. Specialized drugs help to significantly reduce their number. But at the same time, it is necessary to follow a diet, as well as hygiene rules and other advice from a medical specialist.
In order for the elimination of the fungus to be most effective, in addition to drug treatment, the diet should be adjusted.
One of the common indications for the use of Clotrimazole and Pimafucin is candidiasis. This is a fungal disease that appears in the absence of hygiene, as a result of chronic infections. Candidiasis happens:
- nail;
- vaginal;
- oral.
Both drugs are based on imidazole and polyene antimicrobial agents. The substances of the drugs help not only to suppress fungal activity, but to prevent the fungus from spreading further. They are used in the treatment of fungal infections of the vagina, male penis, and skin.
If we are talking about sexual diseases, then if one person is infected, both partners should undergo therapy. What is "Pimafucin" from? The active ingredients of the two medications are different. The active microelement of Pimafucin is natamycin, and the second drug contains clotrimazole.
"Clotrimazole" is not suitable for general use, since it is immediately eliminated from the body.
"Clotrimazole"
According to the instructions for use, Clotrimazole tablets appeared in the seventies of the last century. The active component disrupts the cell membrane of the fungus and key substances are released from it, which helps eliminate fungal cells. The drug affects various pathogens:
- Candida fungi;
- staphylococci;
- streptococci.
Candida fungi are most sensitive to the drug. Clinical studies have confirmed that it is a safe and effective treatment for thrush.
According to the instructions for use, Clotrimazole tablets are not suitable for systemic treatment, since the drug is eliminated from the body almost immediately, and increasing the dosage can provoke intoxication of the body.
"Pimafucin"
The active ingredient is natamycin, it is considered a natural antimicrobial substance. "Pimafucin" is an antifungal drug produced by actinobacteria. Its effect is aimed at ergosterol, with which the microelement binds, as a result of which it prevents the growth of fungal elements.
Natamycin is not absorbed by the mucous cavities of the gastrointestinal tract; with prolonged use of the medication, addiction to it does not occur.
"Pimafucin" eliminates the following fungi:
- nail;
- vaginal;
- cutaneous;
- urethral.
The comparison of Clotrimazole and Pimafucin is based on the following statements.
Both drugs belong to the same therapeutic group - antifungal drugs. They differ in active ingredients. The drug based on natamycin has the following forms:
- vaginal suppositories;
- ointment;
- capsules.
The second drug has more dosage forms. These are gel, cream, ointment, suppositories, vaginal tablets, solution for external application, granules and powder. Both drugs were created to eliminate fungal infections.
How are medications similar?
"Pimafucin" and "Clotrimazole" have the following similar characteristics:
- They are used for the treatment of candidiasis and other fungal diseases in both mild and severe forms.
- Available from pharmacies without a prescription.
- Various release forms.
Both drugs belong to the same therapeutic group.
What is the difference between Clotrimazole and Pimafucin?
In addition to similarities, there are also certain differences between the drugs. These include:
- Natamycin has a milder effect and practically does not penetrate into the blood when used.
- "Pimafucin" can be used throughout pregnancy in the absence of sensitivity to the substance, while the second drug can be used in the second and third trimester.
Pimafucin and Clotrimazole contain different active ingredients. "Pimafucin" acts more gently; during use, the drug practically does not penetrate into the blood. "Clotrimazole" does not have a tablet form for oral use.
The indications for use of the two medications also differ, but not significantly, and the probable adverse reactions also differ.
The cost of drugs also varies, but the differences here largely depend on the manufacturer. What are the instructions for use and the price of Pimafucin and Clotrimazole?
Russian-made drugs are much cheaper than foreign ones, but have a similar effect. "Pimafucin" - from 200 to 700 rubles, "Clotrimazole" - from 20 to 260 rubles.
Which is cheaper?
The price and instructions for use for Pimafucin and Clotrimazole depend on the manufacturer. For example, a foreign-made Clotrimazole cream can cost up to two hundred rubles, while an ointment with the same name from a domestic manufacturer is slightly cheaper. Another medicine in the form of a cream will cost more.
The differences also relate to the cost of the drug for vaginal use. For example, vaginal tablets "Clotrimazole" cost about fifty rubles, and suppositories with a different name cost up to five hundred rubles.
Which is better: "Clotrimazole" or "Pimafucin"
The pharmacological effect and impact of a drug on healthy organs largely depend on how the body reacts to the substances of a particular drug. It is also necessary to take into account whether the patient has other diseases or pathological processes in which it is not recommended to use both medications, or it is possible, but under the strict supervision of a doctor.
For candidiasis
Both medications are recommended for thrush. But it is difficult to determine exactly what works more effectively. The impact depends on the form of the disease - acute or recurrent, and whether the person suffers from diabetes or other diseases.
For vaginal candidiasis, local therapy is usually prescribed: suppositories, vaginal tablets, ointments.
If a woman is diagnosed with thrush, she is prescribed local antifungal medications: suppositories, tablets, creams or ointments. In other situations, the decision is made by a medical specialist on an individual basis.
From actinomycosis (fungal infection)
When choosing a liniment for a skin fungus, you should take into account the characteristics of the body and the prohibitions on the use of a particular medication. These include both of the drugs under consideration. They work best in treating yeast infections on the arms, legs and body.
Clotrimazole ointment is considered a representative of the pharmacological group of antifungal drugs for external use. They are used for treatment that is aimed at eliminating the source of the infectious process caused by drug-sensitive pathogens.
Its antifungal effect is to inhibit the growth and spread of fungal cells with their subsequent elimination due to disruption of the formation of ergosterol, which is the main component of the fungal cell wall.
This leads to a change in permeability, followed by its elimination and death of the fungal cell. In low concentrations, Clotrimazole inhibits the growth and reproduction of the fungus; in higher dosages, it leads to the destruction and death of the fungal cell.
In large dosages, the active component of the drug provokes a change in metabolic processes in the mitochondria of fungal cells with an increase in the intracellular level of hydrogen peroxide. The medication has increased activity against yeast-like and mold fungi, as well as dermatophytes, sources of pityriasis rosea and erythrasma.
Pimafucin cream is a topical antifungal drug.
Liniment is an antimycotic antimicrobial agent with a wide spectrum of effects. Under the influence of the active substance, the growth and spread of fungi and other pathogens sensitive to Natamycin is suppressed. The drug destroys the membrane of the fungus, gets inside and provokes the death of the pathological element.
Yeast-like fungi of the genus Candida are considered the most sensitive to the drug, and dermatophytes are the least sensitive.
There is no information on the use of the drug among children under one year of age, so before therapy you should definitely consult a medical specialist. Which is better: Clotrimazole or Pimafucin?
When eliminating vaginal candidiasis in women, it is best to simultaneously undergo a course of therapy with her sexual partner, otherwise the disease will continue to be transmitted to each other. During treatment with Pimafucin for fungal infections of the genital organs, it is necessary to refrain from intimacy.
During pregnancy
For women during an “interesting situation,” experts usually recommend these medications for treatment and prophylactic purposes to prevent thrush in the form of creams, vaginal suppositories or ointments.
But it must be taken into account that Pimafucin should be used in all trimesters of pregnancy, and the second medication should be used only in the second and third trimester. In addition, suppositories can be prescribed before childbirth to reduce the risk of a fungal infection in the baby as it passes through the birth canal. It is difficult to accurately determine which is better: Clotrimazole or Pimafucin - both drugs are effective in their own way.
For women
Women use drugs in any form, as a rule, for the purpose of treatment and prevention of candidiasis and other fungal infections. A medication in the form of vaginal suppositories has been developed especially for women.
For men
Both medications are prescribed to men to prevent candidiasis balanoposthitis. With proper therapy, the disease goes away completely within fourteen days. When using Pimafucin cream, the itching and burning sensation decreases after a few days, the symptoms disappear completely within ten days. When using the second medication, they go away much faster - within about seven days.
Both Clotrimazole and Pimafucin are drugs aimed at healing the body from fungal infections. It is important to understand that both drugs have approximately the same effect. The difference lies in the substances used. In the case of Clotrimazole, the active substance aimed at destroying the fungus is clotrimazole. In Pimafucin, the role of the active substance is assigned to natamycin.
In this regard, Pimafucin is more suitable, since it is approved for use at any stage of pregnancy. However, Pimafucin is a strong allergen. Initially, it is important to take the minimum dosage to see the real reaction of the body. If there is an allergy (rash on the body, itching of the vaginal mucosa, etc.), the drug is immediately discontinued.
As already mentioned, in the first stages of pregnancy Clotrimazole is not used (in any form). Pimafucin may be prescribed (for example, to combat thrush). It is strictly forbidden to use the drug during pregnancy without the consent of your doctor!
Among the most common side effects of Pimafucin are the following:
- the occurrence of nausea;
- attacks of diarrhea;
- decreased hemoglobin levels;
- stomach disorders.
However, the above side effects appear only during the initial period of using the drug. Subsequently they disappear.
Of course, this does not apply to allergic reactions. Individual intolerance to the drug is the only and sufficient reason for its immediate withdrawal.
In addition to all of the above, the use of Clotrimazole and Pimafucin is prohibited if a pregnant woman has problems with the natural functioning of the kidneys. It is important to understand the possibility of a drug being incompatible with other drugs that a pregnant woman may well use for some reason.
For this reason, early consultation with your doctor is important.
The fact is that if there is a fungus on the mucous membranes of the vagina, then during natural childbirth the baby in 100% of cases becomes infected with candida (the most common causative agent of fungal infections that develop on the mucous membranes of the genital organs).
Therefore, in the last stages of pregnancy, when a fungal disease is diagnosed, the use of Clotrimazole or Pimafucin is integral.
If we talk about affordability, the average price of Clotrimazole is 100 rubles per package. The indicated price is due to a wide range of manufacturers. After all, the drug is produced in Poland, India, Romania, and Russia.
Pimafucin is produced only in the Netherlands. The average retail price in a pharmacy is 450 rubles.
Not only pregnant women are at risk for fungal infections. Moreover, thrush is just as common in the male half of the population. However, in the case of men, it is appropriate to treat with the same drugs, but in a different form.
We are talking about the totality of the effects of tablets, creams, and ointments. While women use candles. Clotrimazole is not produced in the form of oral tablets (exclusively vaginal tablets). As a rule, if Clotrimazole is chosen, men are prescribed a spray.
The video talks about the possibility of taking Clotrimazole during pregnancy:
The drug Pimafucin is an antibiotic that has a fungicidal effect. It contains natamycin, which binds to the membrane of the fungus and disrupts its integrity, as a result of which it dies.
Fungi that are susceptible to the influence of natamycin are considered to be fungi of the genus Candida and other common species, except dermatophytes. Pimafucin is available in round tablets, which are covered with a white coating that easily dissolves in the intestines, in the form of suppositories and cream for the local treatment of thrush.
In addition to natomycin, a dose of 100 mg, the antifungal antibiotic contains excipients such as potato starch, magnesium stearate and lactose monohydrate.
How does Pimafucin work for thrush?
Pimafucin is an antifungal antibiotic belonging to the macrolide group. The fungicidal effect of the drug destroys the integrity of the fungal cell membrane, as a result of which it loses the contents of the cytoplasm and dies.
In medical practice, there has never been an allergy to natamycin, which is part of Pimafucin, since it is a substance of natural origin. When taken orally, the drug does not have a systemic effect and is not absorbed from the intestines.
When using local suppositories, the drug is not absorbed into the skin and mucous membranes, so the use of Pimafucin suppositories is acceptable even during pregnancy and breastfeeding.
In addition to yeast-like fungi, the active component of Pimafucin acts on other harmful microbes and helps against many infectious diseases of the genital tract.
Read the instructions for using Pimafucin for women, men and during pregnancy.
Indications for use
It is advisable to use Pimafucin for any reason that has caused infection with candidiasis. They may be:
- antibiotic treatment;
- decreased immunity;
- pregnancy, etc.
When treated with antibiotics and corticosteroids in patients with weak immunity, atrophic and acute candidiasis may occur. Also, an indication for the use of Pimafucin is intestinal candidiasis.
When using an antimycotic drug, it is worth considering that there is a possibility of its reappearance. This depends on many external and internal factors, such as stress, decreased immunity and other problems in the body.
The drug in tablet form is taken orally, regardless of meals, 4 times a day. The duration of treatment is 1 week. In the form of suppositories, Pimafucin is administered 1 time at night for 6 to 9 days.
Side effects
Side effects of Pimafucin include:
- diarrhea;
- nausea;
- irritation and itching.
Despite the fact that natomycin is a natural substance by nature, side effects often occur. This refers to a drug that comes in the form of . When bonding substances, cetyl alcohol is used, which can cause irritation of the mucous membrane.
It is worth considering that during menstruation the effectiveness of Pimafucin is significantly reduced. Also, the drug Pimafucin contains lactose and sucrose, so it is not recommended for people with intolerance or deficiency of these substances.
There is an opinion that Pimafucin has a contraceptive effect. However, it does not actually contain components that have a spermicidal effect.
How much does Pimafucin cost in pharmacies?
Due to the variety of pharmacies and online stores where you can purchase Pimafucin, it the average cost is 275 rubles for 3 candles and 474 rubles for a bottle of 20 tablets .
Cheaper analogues of Pimafucin (tablets, suppositories and cream)
At the moment there is no complete analogue to the drug Pimafucin. Many drugs like it contain various active substances, but all of them are designed to destroy the membrane of the fungus. Such cheap analogues of Pimafucin include:
- Fluconazole,
- Irunin,
- Nystatin,
- Mikosist,
- Livarol,
- Hexicon,
- Clotrimazole,
- Miconazole and others.
All of the above drugs tend to be absorbed into the blood, which is unacceptable for Pimafucin. They also have many side effects and liver toxicity. Therefore, you should consult your doctor before using them.
Which is better: Clotrimazole, Livarol or Pimafucin?
Unlike Pimafucin, the drug Livarol contains ketoconazole. It is an antimycotic and also causes destruction of the fungal membrane.
Clotrimazole contains a substance of the same name, which is an imidazole derivative. Unlike Pimafucin and Livarol, it has more adverse reactions. Such reactions include:
- allergic itching;
- peeling and tingling of the skin;
- swelling of the mucous membrane;
- frequent urination and discharge.
According to the number of positive reviews about Pimafucin, we can conclude that this drug has a minimum of side effects and is simpler and more reliable. Therefore, when choosing among Livarol, Clotrimazole and Pimafucin, preference should be given to the latter.
