Fenkarol for children: indications for use and instructions. A drug for the relief of acute allergic reactions Fenkarol: instructions for use for children and adults, possible side effects

Fenkarol is a drug with antipruritic, antiallergic, antiexudative and antiedematous action.

Release form and composition

Fenkarol is available in the following forms:

• tablets: flat-cylindrical, round, white or almost white, with a bevel (10 mg and 25 mg - 10 pcs each in blister packs, 2 packs in a cardboard pack; 50 mg - 15 pcs each in blister packs, in a cardboard pack 1 or 2 packs);
• : colorless, transparent liquid (1 ml or 2 ml in colorless glass ampoules, 10 ampoules in blister packs, 1 pack in a cardboard box).

Composition of 1 tablet:

• active ingredient: hifenadine hydrochloride – 10, 25 or 50 mg;
• auxiliary components: sucrose, calcium stearate, potato starch, modified corn starch.

Composition of 1 ml solution:

• active ingredient: hifenadine – 10 mg;
• auxiliary components: glutamic acid, water for injection.

Pharmacological properties

Pharmacodynamics

Hifenadine, the active substance of Fenkarol, is a blocker of H1-histamine receptors. It prevents the development of allergies and eases its course. The drug has antipruritic, antiexudative and antiallergic effects, preventing the development of allergic inflammation in tissues.

Fenkarol weakens the bronchospastic effect of histamine, reduces its effect on vascular permeability (thus providing an anti-edematous effect), reduces the spasmogenic effect of histamine on the smooth muscles of the intestine, and suppresses its hypotensive effect. By activating diamine oxidase (an enzyme capable of inactivating histamine), the drug reduces the content of histamine in tissues. The antihistamine effect of Fenkarol does not decrease during the course of treatment.

The drug also has weak m-anticholinergic activity and has a moderate antiserotonin effect. Does not depress the central nervous system.

Pharmacokinetics

After oral administration, approximately 45% of quifenadine is rapidly absorbed from the gastrointestinal tract and after 30 minutes the drug is detected in tissues. The maximum concentration of quifenadine in plasma is reached after approximately 1 hour. The drug has low lipophilicity and penetrates the blood-brain barrier in small quantities. The highest content of quifenadine was observed in the liver, slightly less in the kidneys and lungs, and the lowest concentration of the active substance was found in the brain (less than 0.05%, which explains the lack of inhibition of the central nervous system). Metabolism of Fenkarol occurs in the liver. The resulting metabolites are excreted by the kidneys. The part of the drug that is not absorbed is excreted through the intestines.

The pharmacokinetics of the solution for intramuscular administration are similar to the pharmacokinetics of the drug in tablet form.

Indications for use

Pills

• allergic rhinitis;
• angioedema;
• chronic and acute urticaria;
• dermatoses (including neurodermatitis, psoriasis, eczema and itchy skin).

Solution for intramuscular administration

• hay fever (seasonal allergic rhinoconjunctivitis);
• angioedema;
• hives.

Fenkarol in the form of an injection solution is used in cases of severe disease, when intramuscular administration of antihistamines is necessary.

Contraindications

Absolute contraindications common to both dosage forms:

• pregnancy period;
• breastfeeding period;
• hypersensitivity to quifenadine or auxiliary components of the drug.

Relative contraindications common to both dosage forms (Fenkarol is used with caution):

• kidney and liver diseases;
• diseases of the gastrointestinal tract.

Additional absolute contraindications for Fenkarol in tablet form:

• children under 3 years of age (for tablets 10 mg and 25 mg);
• children and adolescents up to 18 years of age (for tablets 50 mg);
• fructose intolerance, sucrase/isomaltase deficiency, glucose-galactose malabsorption (since the tablets contain sucrose).

Fenkarol in the form of a solution for intramuscular administration is also contraindicated in children and adolescents under 18 years of age; it is prescribed with caution to patients with decompensated diseases of the cardiovascular system.

Directions for use and dosage

Pills

Fenkarol in tablet form is taken orally after meals.

The dosage regimen of the drug is the same for all available indications for use. The dosage regimen may be influenced by the severity of allergic reactions, possible side effects and the patient's individual sensitivity to quinfenadine.

• 3–7 years – 10 mg twice a day;
• 7–12 years – 10–15 mg two or three times a day;
• over 12 years old - 25 mg two or three times a day.

The duration of treatment in children is 10–15 days.

For adult patients, Fenkarol is prescribed 25 mg two to four times a day or 50 mg one to four times a day. The maximum daily dose is 200 mg. The duration of therapy averages from 10 to 20 days. If necessary, a repeat course is possible.

Solution for intramuscular administration

Fenkarol in the form of a solution is administered intramuscularly. Subcutaneous administration is prohibited due to the irritant effect of the drug.

For hay fever, the solution is administered twice a day, 2 ml for 3 days, then once a day, 2 ml for another 2 days. The general course of treatment is 5 days.

For angioedema and urticaria, Fenkarol is administered twice a day, 2 ml for 5 days, then once a day, 2 ml for another 3 days. The general course of treatment is 8 days.

Maximum doses: single – 20 mg, daily – 40 mg.

After relieving the symptoms of acute allergic reactions, it is recommended to transfer the patient to the oral form of the drug in the form of tablets.

Side effects

Fenkarol is usually well tolerated by patients. In rare cases, nausea, vomiting, dry mouth, headache, drowsiness and allergic reactions may occur.

Overdose

In case of an overdose of hifenadine, the following symptoms are observed: vomiting, headache, dyspeptic disorders, abdominal pain, dry mucous membranes.

In case of accidental overdose of Fenkarol, you should rinse your stomach, drink activated charcoal and immediately consult a doctor who will prescribe symptomatic therapy.

Special instructions

The drug can be used in patients for whom antihistamines that have an anticholinergic effect are contraindicated. This is due to the fact that Fenkarol does not have a pronounced anticholinergic effect.

Impact on the ability to drive vehicles and complex mechanisms

The drug can be used by people whose work is associated with increased concentration and speed of psychomotor reactions, but it is first recommended to determine the patient’s individual sensitivity to Fenkarol and make sure that the drug does not have a sedative effect.

Use during pregnancy and lactation

Fenkarol is contraindicated in pregnant women.

If it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued.

Use in childhood

Fenkarol in the form of 10 mg and 25 mg tablets is contraindicated in children under 3 years of age, and 50 mg tablets and solution for intramuscular administration are contraindicated in children and adolescents under 18 years of age.

Children aged 3–18 years can be prescribed tablets in dosages of 10 mg and 25 mg.

For impaired renal function

For patients with kidney disease, Fenkarol is prescribed with caution.

For liver dysfunction

For patients with liver diseases, Fenkarol is prescribed with caution.

Drug interactions

Hifenadine has weak m-anticholinergic activity, can reduce gastrointestinal motility and increase the absorption of slowly absorbed drugs, for example, indirect anticoagulants that are coumarin derivatives.

The drug does not enhance the inhibitory effect of sleeping pills and alcohol on the central nervous system.

Analogs

Analogues of Fenkarol are: Alernova, Alersis, Alergostop, Altiva, Alerik, Alergomax, Diazolin, Histafen, Claritin, Ketotifen, Kestin, Lordes, Laurent, Laurent ODT, Loratadine, Lorizan, Peritol, Semprex, Telfast, Tigofast, Trexil Neo, Fexofast, Fexomax, Fribris, Fexofen-Sanovel, Erius, Eden, Eridez, Erolin.

Terms and conditions of storage

Store in a place protected from light and moisture at a temperature of no more than 25 °C. Keep away from children.

Shelf life: tablets 10 mg and 25 mg – 5 years; tablets 50 mg – 4 years; solution for intramuscular administration – 2 years.

Conditions for dispensing from pharmacies

The tablets are available without a prescription.

The solution for intramuscular administration is available by prescription.

Active ingredient

Quifenadine hydrochloride

Release form, composition and packaging

◊ Pills white or almost white, round, flat-cylindrical, with a chamfer and a notch.

Excipients: potato starch - 14.5 mg, sucrose - 25 mg, calcium stearate - 0.5 mg.

◊ Pills

Excipients: potato starch - 40.5 mg, sucrose - 33.5 mg, calcium stearate - 1 mg.

10 pcs. - contour cell packaging (2) - cardboard packs.

◊ Pills white or almost white, round, flat-cylindrical, chamfered.

Excipients: potato starch - 74 mg, sucrose - 55 mg, modified corn starch - 20 mg, calcium stearate - 1 mg.

15 pcs. - contour cell packaging (1) - cardboard packs.
15 pcs. - contour cell packaging (2) - cardboard packs.

Pharmacological action

Histamine H1 receptor blocker. Prevents the development and facilitates the course of allergic reactions. It has antiallergic, antiexudative and action, preventing the development of allergic inflammation in the tissue. Weakens the effect of histamine, reduces its effect on vascular permeability (by reducing permeability, it has an anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on intestinal smooth muscles, weakens the hypotensive effect of histamine. Hifenadine reduces the content of histamine in tissues (associated with the ability to activate diamine oxidase, an enzyme that inactivates histamine). During a course of treatment, the antihistamine effect of quifenadine does not decrease. It has a moderate antiserotonin effect and exhibits weak m-anticholinergic activity. Does not have a depressing effect on the central nervous system.

Pharmacokinetics

Suction and distribution

Hifenadine is quickly absorbed from the gastrointestinal tract, absorption is 45%, and after 30 minutes it is found in body tissues. Cmax in the blood is reached after 1 hour. It has low lipophilicity and does not penetrate well through the BBB. The highest concentration of the active substance is found in the liver, somewhat lower - in the lungs and kidneys, the lowest - in the brain (less than 0.05%, which explains the absence of a pronounced sedative and hypnotic effect).

Metabolism and excretion

Hifenadine is metabolized in the liver.

Metabolites are excreted by the kidneys and intestines. The unabsorbed portion of the drug is excreted through the intestines.

Indications

- hay fever;

- acute and chronic urticaria;

- angioedema;

- allergic rhinitis;

— dermatoses (including eczema, psoriasis);

— neurodermatitis;

- skin itching.

Contraindications

- pregnancy;

- lactation period (breastfeeding);

- children under 3 years of age (for tablets 10 mg and 25 mg);

- children and adolescents up to 18 years of age (for 50 mg tablets);

- sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, because the drug contains sucrose;

- hypersensitivity to the components of the drug.

With caution The drug should be prescribed for diseases of the gastrointestinal tract, liver and kidneys.

Dosage

The drug is taken orally after meals.

The dosage regimen of the drug is the same for all indications for use. The dosage of quifenadine may be influenced by the severity of the allergic reaction, the individual sensitivity of the patient, as well as the severity of possible side effects.

For adults prescribed 50 mg 1-4 times/day or 25 mg 2-4 times/day. The maximum daily dose is 200 mg. The average course of treatment is 10-20 days. If necessary, the course of treatment is repeated.

For children aged 3 to 7 years- 10 mg 2 times/day; aged 7 to 12 years- 10-15 mg 2-3 times/day; over 12 years old- 25 mg 2-3 times/day. The course of treatment is 10-15 days.

Side effects

From the digestive system: dryness of the oral mucosa, nausea, vomiting.

From the side of the central nervous system: drowsiness, headache.

Others: allergic reactions.

Overdose

Symptoms: dry mucous membranes, headache, vomiting, and other symptoms of dyspepsia.

Treatment: gastric lavage, taking activated carbon, carrying out symptomatic therapy.

In case of overdose, the patient should consult a doctor.

Drug interactions

Hifenadine does not enhance the inhibitory effect of ethanol and hypnotics on the central nervous system.

Having weak m-anticholinergic properties, the drug can reduce gastrointestinal motility, which helps to increase the absorption of slowly absorbed drugs (for example, indirect action - coumarins).

Special instructions

The absence of a pronounced m-anticholinergic effect allows the drug to be prescribed to patients for whom antihistamines with m-anticholinergic activity are contraindicated.

Use in pediatrics

Registration number: LP 002387-270214
Trade name of the drug: Fenkarol.
International nonproprietary name: hifenadine.
Dosage form: solution for intramuscular administration.

Composition per 1 ml of finished product:
Active ingredient: hifenadine (fenkarol base), calculated as 100% substance 10.00 mg;
Excipients: glutamic acid 6.26 mg, water for injection up to 1.0 ml.

Description: transparent colorless liquid.

Pharmacotherapeutic group: antiallergic agent - H1-histamine receptor blocker.

ATX code

Pharmacological properties

Pharmacodynamics
The active ingredient of the drug hifenadine is a blocker of H1-histamine receptors, prevents the development and facilitates the course of allergic reactions. It has antiallergic, antiexudative and antipruritic effects, preventing the development of allergic inflammation in the tissue. Weakens the effect of histamine, reduces its effect on vascular permeability (by reducing permeability, it has an anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on intestinal smooth muscles, weakens the hypotensive effect of histamine. Hifenadine reduces the content of histamine in tissues (associated with the ability to activate diamine oxidase, an enzyme that inactivates histamine). During a course of treatment, the antihistamine effect of quifenadine does not decrease. It has a moderate antiserotonin effect and exhibits weak m-anticholinergic activity. Does not have a depressing effect on the central nervous system.
Pharmacokinetics
After intramuscular (IM) administration, the solution is rapidly absorbed and the maximum concentration of quifenadine in the blood plasma is achieved after 30 minutes. Hifenadine has low lipophilicity and does not penetrate the blood-brain barrier well. The highest content of the active substance was observed in the liver, somewhat less in the lungs and kidneys, the lowest in the brain (less than 0.05%, which explains the absence of a pronounced sedative and hypnotic effect). The drug is metabolized in the liver, forming inactive metabolites, which are excreted primarily by the kidneys.

Indications for use

Hay fever, urticaria, angioedema (Quincke's edema) in case of severe disease and the need for intramuscular use of antihistamines.

Contraindications

Individual intolerance to quifenadine.
Hypersensitivity to any of the components of the drug.
Children under 18 years of age.
Pregnancy and breastfeeding period.

With caution for decompensated diseases of the cardiovascular system, gastrointestinal tract, liver and kidneys.

Use during pregnancy and breastfeeding

Directions for use and doses

Intramuscularly. Subcutaneous administration is not used due to irritation.
Hay fever
2 ml (20 mg) 2 times a day for 3 days, then 2 ml (20 mg) 1 time a day for 2 days. The total duration of treatment is 5 days.

Urticaria and angioedema (Quincke's edema)
2 ml (20 mg) 2 times a day for 5 days, then 2 ml (20 mg) 1 time a day for 3 days. The total duration of treatment is 8 days.
The maximum single dose is 20 mg; the maximum daily dose is 40 mg.
After relief of acute allergic reactions, it is recommended to switch to the use of the drug Fenkarol in tablet form.

Side effect

The drug is well tolerated. Rarely possible adverse reactions: dryness of the oral mucosa, nausea, vomiting, drowsiness, allergic reactions, headache.

Overdose

Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other dyspeptic symptoms. Treatment is symptomatic. It is necessary to take activated carbon and consult a doctor immediately.

Interaction with other drugs

Does not enhance the inhibitory effect of alcohol and hypnotics on the central nervous system. Having weak M-anticholinergic properties, it can reduce gastrointestinal motility and increase the absorption of slowly absorbed drugs (for example, indirect anticoagulants - coumarin derivatives).

Special instructions

The absence of a pronounced anticholinergic effect makes it possible to prescribe antihistamines with anticholinergic activity to patients for whom antihistamines with anticholinergic activity are contraindicated.
Impact on the ability to drive vehicles and maintain potentially dangerous mechanisms
Persons whose profession requires increased concentration and speed of psychomotor reactions should first determine (by short-term prescription) whether the drug has a sedative effect.

Release form
Solution for intramuscular administration 10 mg/ml.
1 ml or 2 ml of the drug in neutral glass ampoules.
10 ampoules are placed in a blister pack made of transparent polyvinyl chloride film. 1 blister pack along with instructions for use is placed in cardboard packs.

Many people suffer from allergies. These hypersensitive reactions of the body to various pathogens do not allow one to live in peace. This article will present one of the best solutions to the problem that anyone can use. It doesn't cost a fortune and works great 90% of the time.

Many people are interested in one question: “What are Fenkarol tablets for?” This drug is designated by doctors as an antihistamine. That is, it reduces the amount of histamines affecting every human organ and system. Its unique description of action makes it very different from other drugs with the same mechanism.

Acting as a blocker of histamine Hi receptors inside each tissue, Fenkarol activates histaminase. Another name for it is the enzyme diamine oxidase. This is how the required level of histamine is achieved.

The effectiveness of using such a medicine for patients is difficult to overestimate, especially in cases where similar remedies have failed to cope with the task. When taken, each tablet will be quickly absorbed into the gastrointestinal tract. After half an hour, an improvement in the person’s condition is already observed. And after the same period of time, the maximum concentration in the blood is heard. This medication is metabolized only in the liver. Each metabolite is excreted through urine after two days.

Composition, active substance, release forms

There is only one active substance - quifenadine. He is the foundation. Of 100% of the substance there are 10 milligrams. The auxiliary components are water used for the injection solution, up to 1 milliliter, and glutamic acid, present in an amount of 6.26 milligrams. A solution is created in such proportions and administered intramuscularly.

The tablets are manufactured in these parameters. The active component does not change. His dose remains the same. Excipients will be the content of potato starch, the presence of sucrose, corn starch, calcium stearate. Together they should make up 100% of one tablet, minus the amount of quifenadine.

Gel and cream are dispensed in the form of a liquid, without any color and not containing anything. The tablets are white. Small cylinder shape. If the tablet has 10 mg of the active ingredient, then no special mark will be applied to it.

Dispensed only with a doctor's prescription!!!

How to take medicine for adults and children - dosage, instructions

Being decongestant, antiallergic, antipruritic, antiexudative, it is used as one of the best remedies against allergic reactions. It is the action of the active component that prevents the development and makes the course of the disease calmer. Also, when taken, a decrease in itching and inflammation in the tissues is noticed.

By making any action of histamine weaker, these products completely reduce its effect on blood vessels. They become more permeable, allowing blood to move faster.

There is also a decrease in bronchospastic effect and spasmogenic effect on intestinal smooth muscles. The hypotensive effects of histamine become less, which makes its amount in tissues less. All enzymes that activate it completely calm down and go away.

Even long-term treatment will not reduce the effectiveness of the main element. Mild antiserotonin actions do not affect cholimone blocking activity at all. In 100% of patients, no effects or effects on the central nervous system were observed.

Before use, you need to study Fenkarol; the instructions for use describe very rapid absorption with intramuscular injection. In this case, the peak value of the component in the blood is reached twice as fast. Since it has low lyophilicity, it crosses the blood-brain barrier very poorly. The highest concentration is observed in the human liver. The respiratory and fluid removal systems lag far behind in this indicator. The brain will contain the least of all. Therefore, when taking it, a person does not calm down or fall asleep. Excreted through urine.

In tablet form, almost half of the active substance is absorbed very quickly inside the stomach and intestines. Only after this action does the 30-minute countdown begin so that hifenadine reaches all its tissues throughout the body. The maximum amount in the blood will be only 60 minutes after taking it. All chemical properties are the same as for injections and balm, but in this case the unabsorbed part will be excreted by the liver.

As the abstract states, in both options, adults take 50 mg per day up to four times a day. Based on this indicator, calculate everything else! Always only after eating.

There is also a weaker Fenkarol, the instructions for children are the same as for adults, but the content of active components in it and the total dosage are much less than in the adult version.

Some parents, due to poor genetics, give their children this drug from birth, sometimes using ointment. Doctors have never been able to prove a negative effect, even in the absence of symptoms. But, it is better to undergo additional consultation with a pediatrician.

Children are given when they appear:

• Manifestations of urticaria on the skin;
• Various eczemas;
• Psoriasis;
• A runny nose that begins at the first sign of an allergy.

Fenkarol for children copes well with diseases such as:

• Hay fever;
• Neurodermatitis;
• Allergy with signs of suffocation.

Tablets of 10 milligrams are given to children when they have atopic dermatitis, severe allergic swelling, severe itching on the skin, and hay fever.

Immediately before vaccinations, taking Fenkarol is prohibited in cases where allergies are at their peak. The course must be completed before vaccination begins.

The pediatrician should calculate dosage according to the patient's age. Proper treatment greatly reduces the risk of swelling or rashes. The course always consists of a two-week period. Take after meals.

Features of use during pregnancy and lactation

Reception is prohibited throughout. If a woman is at the lactation stage, then the baby will have to drink the formula. If these features are violated, side effects are possible not only for the mother, but also for the child. Namely: dry mucous membrane in the oral cavity, nausea, drowsiness, headaches.

Fenkarol's analogs

There is a fairly impressive list of similar medications to Fenkarol. Analogues even half may not have the same effect. But according to the principle of action, each substitute is similar:

• Aleric;
• Dezal;
• Clarisens;
• Histaphen;
• Loratek;
• Telfast;
• Peritol.

Analogs of the drug, of course, can solve the problem, but not with the same effect. It all comes down to a strong core component.

Contraindications, side effects

In all dosage forms it is prohibited to use:

• If the body completely refuses to take quifenadine. And also with strong sensitivity to other chemical elements of the drug.
• When a girl is carrying a fetus at any stage.
• DURING lactation.
• Any alcoholic drink.

With a little caution, it is possible for diseases of the digestive system, liver and kidney dysfunctions.

Persons under 18 years of age are prohibited from any intravenous injections. The manual clearly describes that tablets are not given for sucrose deficiency or individual fructose intolerance in children. Their active ingredient content should not exceed 10 mg for up to three years.

Compatibility of the drug with alcohol. Does not enhance the effects of alcoholic drinks. Careful use is possible!

Interaction with other drugs

With other sedatives they do not increase. But any combination with other drugs changes the concentration in the blood of slowly absorbing drugs. For example, coumarin. Compatible with alcohol in small doses.

Active ingredient: fenkarol (Quifenadini hydrochloridum) 25 mg.
Excipients: sugar, potato starch, calcium stearate.

Description

Tablets for oral administration.

Pharmacological action

Fenkarol is an antihistamine that reduces the effects of histamine on the organs and systems of the body. Unlike other classical drugs in this group, fenkarol has a special mechanism of action: the drug blocks histamine Hi-receptors in peripheral tissues, and also activates the enzyme diamine oxidase (histaminase), thus reducing the content of histamine in tissues. This explains the effectiveness of fenkarol for patients whose treatment with other antihistamines is ineffective.
Fenkarol is quickly absorbed from the gastrointestinal tract and is found in body tissues within 30 minutes. The maximum concentration of the active substance in the blood plasma is reached after an hour. Fenkarol is metabolized in the liver. Metabolites of fenkarol and the unchanged portion of the drug are excreted mainly in urine and bile within 48 hours.

Indications for use

Hay fever, acute and chronic urticaria, allergic rhinitis, allergic conjunctivitis, angioedema, dermatoses (eczema, neurodermatitis, skin itching, etc.), allergic reactions associated with taking medications or foods.

Contraindications

Hypersensitivity to fenkarol or excipients of the drug. The drug is not recommended to be taken during pregnancy and breastfeeding; it is contraindicated in the first 3 months of pregnancy.

Pregnancy and lactation

Directions for use and doses

Fenkarol is taken orally immediately after meals.
Dose for adults: 25-50 mg 2-4 times a day. The maximum daily dose is 200 mg.
Children over 12 years old - 25 mg 2-3 times a day. The duration of the course of treatment is 10-20 days. If necessary, the course is repeated.
If you miss a dose, take the drug as soon as you remember, but skip it if it is almost time for your next dose. Never take double doses.

Side effect

In case of hypersensitivity or overdose, moderate dry mouth and dyspeptic symptoms are possible, which usually disappear when the dose is reduced or the drug is discontinued. In persons with diseases of the gastrointestinal tract, the possibility of side effects increases. In some cases, a calming effect
If side effects occur, especially those that are not listed in the instructions for use, you should consult a doctor.

Overdose

If you suspect an overdose, call a doctor immediately. Symptoms: dry mucous membranes, headache, vomiting, stomach pain and dyspepsia.

Interaction with other drugs

Fenkarol does not enhance the inhibitory effect of alcohol and hypnotics on the central nervous system (CNS). Fenkarol has weak M-anticholinergic properties, but with a decrease in gastrointestinal motility, the absorption of slowly absorbed medications may increase (for example, indirect anticoagulants - coumarins).

Features of application

Fenkarol does not have a pronounced inhibitory effect on the central nervous system, but in some cases a weak sedative effect is observed.
Effect on ability to drive a vehicle
Persons whose work requires a quick physical or mental reaction (transport drivers, etc.) should first determine (by short-term administration) whether the drug has a sedative effect. Persons who exhibit a sedative effect of the drug are not recommended to drive a vehicle or engage in dangerous driving.