Side effects of Cortexin. "Cortexin": instructions for the use of intramuscular injections for children, side effects of the drug

The brain is the main organ of the central nervous system, which is why its normal functioning is so important. Moreover, it is necessary to maintain the functioning of neurons after injuries and various circulatory disorders of brain tissue. To restore correct brain activity, nootropic drugs are prescribed, one of which is Cortexin - injections of this medication are widely used in neurological practice and pediatrics.

Indications for the use of Cortexin injections

The main effects of the drug in question are due to the properties of the active ingredient of the same name:

• neuroprotective;
• nootropic;
• tissue specific;
• antioxidant.

Thanks to this, the medicine is able to:

• protect neurons from the effects of toxic and psychotropic substances;
• prevent the influence of neurotoxic endogenous factors;
• improve learning processes and higher brain functions;
• increase concentration;
• maintain the stability of the nervous system in a state of stress;
• activate neuronal metabolism;
• restore the general tone of the nervous system and the function of the cerebral cortex;
• intensify reparative processes;
• inhibit lipid oxidation in neuronal cells;
• prevent the death of neurons under conditions of hypoxia and oxidative stress.

According to the instructions, Cortexin injections are prescribed for the following pathologies and conditions:

• diverse origin;
• suprasegmental disorders of the autonomic nervous system;
• cognitive impairment in the form of deterioration of memory and thinking abilities;
• traumatic brain injuries, their complications and consequences;
• asthenic conditions;
• acute, chronic encephalomyelitis, encephalitis;
• , as well as complications of strokes;
• decreased ability to learn and concentrate;
• epilepsy.

In pediatrics, the presented drug is used in the complex treatment of cerebral palsy, delayed speech and psychomotor development in children. Treatment of critical conditions of newborns due to intrauterine and postpartum damage to the nervous system is possible.

How to dilute Cortexin for injection?

The described medicine is available in the form of a powder (lyophilisate) intended for the preparation of a solution. This way, polypeptide fractions better retain their active properties.

• water for injections;
• Novocaine (0.5%);
• sodium chloride solution with a concentration of 0.9%;
• Procaine (0.5%).

Other agents similar in mechanism of action to the above solutions, for example, Lidocaine, should not be used.

How to give Cortexin injection?

First you need to properly dilute the lyophilisate. To do this, the stopper of the bottle is pierced with a needle, and 1-2 ml of one of the indicated liquids is injected through a syringe. It is recommended to direct the solution stream towards the wall of the bottle, as this will avoid intense foam formation. There is no need to shake the resulting composition.

The existing solution should be drawn into a syringe and administered intramuscularly to the patient at medium speed. It is important to monitor whether the patient tolerates the Cortexin injection well or not. These injections are painless, but may cause discomfort if dilution of the powder results in a large number of air bubbles.

The standard dosage of the drug for adults is 10 mg of lyophilisate once a day for 10 days. For ischemic strokes or their complications, double injections are prescribed in the same dose, but after 10 days the course of treatment must be repeated.

Cortexin is one of the nootropic drugs used in injection form. Ampoules with the drug contain a lyophilisate for preparing a solution, which is administered strictly intramuscularly and is a combination of soluble peptide molecules (10 mg per 1 bottle), glycine (12 mg) is used as a stabilizer and auxiliary component, the volume of the bottle is 5 ml. Less commonly used are bottles containing 5 mg of active ingredient. The molecules are isolated from the cerebral cortex of livestock (cows or pigs) no older than one year of age, which sometimes sounds scary for the patient, especially with the introduction of the law on prescribing the drug by international nonproprietary name.

Pharmacologically, Cortexin has a complex nootropic, neuroprotective, antioxidant and tissue-specific effect. The drug penetrates well through the blood-brain barrier.

The nootropic effect is expressed in the form of improvement of all cognitive processes, as well as in the form of increased resistance to stress. Neuroprotection is achieved by reducing the toxic effects of endogenous factors (glutamate, free radicals), as well as other neurotoxic substances. Inhibition of lipid peroxidation leads to improved neuronal survival under conditions of hypoxia and stress. Activation of the metabolism of neurons and their reparative processes helps to normalize and improve the tone of the nervous system, including the human cerebral cortex.

The mechanism of action lies in the activation of neurotrophic factors, normalization of the ratio of activation and inhibitory amino acids, and a decrease in convulsive activity. Also, inhibition of lipid peroxidation and activation of the peptide metabolic system of the neurons themselves lead to improved bioelectrical interactions in the nervous system.

It is not possible to determine the activity of Cortexin components pharmacokinetically due to the multitude of active polypeptide molecules and its versatile action.

Indications for use

Cortexin can be used in most neurological diseases accompanied by suffering in the central and, to a lesser extent, peripheral nervous system. Indications for use are the following conditions:

• Acute period of traumatic brain injury and.
• Astheno-neurotic syndrome of various origins.
• Encephalitis and encephalomyelitis.
• Cognitive impairment.
• Developmental delay in children.
• Perinatal damage to the nervous system, including.

Contraindications

The use of the drug has a number of restrictions:

• Pregnancy at any stage.
• Breastfeeding period.
• Allergic reactions and intolerance reactions to Cortexin components.

Dosage

The drug is used for intramuscular administration, having previously dissolved the contents of one bottle in 1-2 ml of a half-percent solution of novocaine, injection water or saline. For adults, use is indicated in a dosage of 10 mg once a day for a course of up to 10 days, for children up to 20 kg in doses of half a milligram per kilogram of weight, for those weighing more than 20 kg, adult dosages are used, the course of treatment is also ten days. Repeated courses can be carried out after 3-4 months.

The drug Cortexin refers to polypeptides isolated from the cerebral cortex of pigs and cattle. It is considered a nootropic drug, that is, a drug that can have a positive effect on the mechanisms of memorization and memory, but not only on them. So that you know more about what the medicine Cortexin is, instructions, indications for use, side effects, analogue, dosage, contraindications, I devoted my article to this on the www.site.

Description

According to the manufacturers, Cortexin is capable of exerting a tissue-specific effect on the cerebral cortex. It improves nerve control processes and helps restore neurons in the cerebral cortex. The drug also helps the body adapt to the variability of its environment. It is also claimed as a remedy that can activate the functioning of the cerebral cortex and provide an antioxidant antitoxic effect in response to inflammatory processes and neurotropic substances.

pharmachologic effect

Cortexin improves brain metabolism. It is a lyophilisate from the blue and bovine cerebral cortex and contains active neuropeptides that are able to penetrate the blood-brain barrier.

It regulates the ratio of excitatory and inhibitory amino acids and the processes of lipid oxidation in the brain, thereby helping to restore the bioelectrical activity of the brain.

When cognitive functions are impaired, a positive effect from taking the drug is also observed. At the same time, it is able to influence short-term memory, concentration and learning ability. After various stressful effects on the brain, the drug helps restore brain function. It also keeps serotonin and dopamine in balance.

Indications for use

Cortexin is highly effective for stress and traumatic brain injuries; in case of disturbances in the blood circulation of the brain; various types of encephalopathies; viral and bacterial infections; reduced learning ability, memory and intelligence impairments; mental retardation in children; asthenia; cerebral palsy; various forms of autonomic disorders.

Contraindications Cortexin

The only clearly defined contraindication is individual intolerance to the drug. But the safety of using the drug during pregnancy and breastfeeding has not been proven, so it is usually included in the contraindications. If treatment with Cortexin is necessary during lactation, feeding must be stopped.

Side effects

Side effects of Cortexin may occur, except perhaps as a result of hypersensitivity.

Application of Cortexin

The medicine is administered intramuscularly. At the same time, it is important to know how and with what to dilute Cortexin so that its dosage is correct. So, the powder from the bottle must be dissolved in 1-2 ml of water for injection, 9% sodium chloride solution, 5% procaine solution. The drug must be administered once a day.

Adults are prescribed a dose of 10 mg/day. Course duration is up to 10 days.
The same dose is recommended for children weighing more than 20 kg.

Children up to 20 kg are prescribed 5 mg/day. It is possible to use Cortexin from the first days of a child’s life.

If necessary, the course of drug treatment can be repeated within a month to six months.

Interaction of the drug with other drugs

Cortexin is prescribed in combination with other medications. However, there were no reports of adverse effects from the interaction.

Release form Cortexin

The medicine is sold in 10 mg bottles. Intended for intramuscular administration in the form of a solution. The manufacturer of Cortexin is the company "Geropharm".

Analogue

Cortexin for children, polypeptides of the cerebral cortex of cattle

Storage conditions for Cortexin

It is necessary to store the drug in a dry place, the recommended storage temperature is from 2 to 10C.

Special instructions for use

The drug can be prescribed to persons working with equipment and drivers, as it does not have an inhibitory effect.

Also keep in mind that the instructions for use presented on the website www.site are given in a free form, and therefore before taking the drug Cortexin you must study the official instructions and consult with your doctor.

The drug is available in the form of a sterile lyophilized powder for the preparation of a solution for intramuscular administration.

The cardboard packaging is completed with two blister packs, each containing 5 bottles of lyophilisate, and instructions for use.

In pharmacies you can buy Cortexin 10 mg No. 10 and Cortexin 5 mg No. 10.

Cortexin 10 mg is available in 22 mg doses in 5 ml bottles. The product is intended for the treatment of adult patients.

Cortexin 5 mg was created specifically for use in pediatrics. It is available in 11 g bottles with a capacity of 3 ml.

Cortexin belongs to the group nootropic and gamkergic drugs, affecting mainly CNS. Against the background of its use, the following are noted:

• nootropic;
• neuroprotective;
• antioxidant;
• tissue-specific effects.

Cortexin is a bioregulator with a polypeptide structure, which is a complex of water-soluble neuropeptides. The molecular weight of these polypeptide fractions does not exceed 10 thousand daltons, which allows them to penetrate the physiological barrier separating central nervous And circulatory system.

The mechanism of action of the drug is realized through:

• activation of regulatory peptides, neurons And brain neurotrophic factors;
• normalization of the ratio amino acids, performing mediator functions of excitatory and inhibitory types of action, as well as important brain neurotransmitters dopamine And serotonin;
• moderately expressed GABA-ergic effects;
• reducing the level of paroxysmal (attack-like) convulsive activity brain and the ability to normalize the indicators of its bioelectric activity;
• preventing the formation of oxidative degradation products lipids(free radicals).

The nootropic effect of Cortexin is accompanied by improvement higher brain functions, improving memory, increasing learning ability and stress resistance.

The neuroprotective effect is manifested in the ability of the product to increase tissue resistance brain to the damaging effects of various endogenous neurotoxic factors and reduce the toxic effects of neurotropic substances.

Antioxidant action manifested in the drug’s ability to influence oxidative stress (cell damage provoked by oxidative processes) and increase the survival rates of neurons under conditions of oxygen starvation.

The mechanism of this action is associated with the suppression of free radical processes and peroxide oxidation of cell membrane lipids, as well as with the correction of oxygen-dependent pathological conditions.

As a result: the destruction process slows down cell membranes, microcirculation improves, decreases permeability of vessel walls, the level of substances contained in the blood is normalized cholesterol And triglycerides.

The tissue-specific effect of the drug is associated with an increase in intensity metabolism of CNS neurons And PNS, stimulation of reparative processes in CNS, improvement of functional state cerebral cortex and general tone somatic and autonomic nervous system.

Pharmacokinetic characteristics cannot be determined, since the disintegration time of the L-series amino acids and neuropeptide fractions included in the active substance Cortexin is no more than 3 minutes.

This makes it impossible to establish the rate and extent of absorption of peptide residues, their distribution among various organs and tissues, as well as the rate and routes of their excretion from the body.

Indications for use of the drug are:

• provoked bacteria or viruses infectious diseases of the nervous system;
• conditions accompanied by a violation blood circulation in the brain;
• TBI and its consequences;
• diffuse brain lesion syndrome different nature of origin;
• cerebral (suprasegmental) autonomic disorders.

In combination with other drugs, the drug is prescribed for treatment epilepsy, as well as for treatment acute and chronic inflammatory diseases of the brain and/or spinal cord of various etiologies.

For children, indications for the use of Cortexin are reduced learning ability, memory and thinking disorders, child retardation syndrome psychomotor and speech development(ZPRR), various forms cerebral palsy.

The drug is contraindicated in patients with hypersensitivity to cortexin and/or glycine.

Clinical studies to establish the effect of the drug on the body of a pregnant woman and the developing fetus have not been conducted. For this reason, the drug is not recommended for use at any stage of pregnancy.

Since there are no data from clinical studies regarding the use of the drug during breastfeeding, if it is necessary to prescribe Cortexin, it is recommended to stop breastfeeding.

Potential side effects include allergic reactions, due to individual sensitivity to the components included in the drug.

The drug is intended for injection into the muscle.

Before injection, the powder contained in the bottle should be diluted with one or two milliliters of a 0.5% solution procaine (novocaine), saline solution(isotonic sodium chloride solution (0.9%)) or water for injection.

To prevent the formation of foam, they try to direct the needle towards the wall of the bottle.

Cortexin can be prescribed from the first days of life. In some situations, parents have to give their child injections themselves. And here questions arise about how to properly inject Cortexin and what is the best way to dilute the powder.

Before giving the injection, water for injection is drawn into the syringe, novocaine or saline solution, then pierce the lid of the bottle and pour the collected liquid into it.

The syringe should be removed (the needle remains in the cap) and the contents of the bottle should be thoroughly shaken until the powder is completely dissolved. After this, the syringe is reattached and the required amount of solution is drawn into it.

For an injection, it is better to take a new needle, since the needle with which the solvent for the lyophilisate was injected may already be fairly dull.

The medicine is administered slowly, as rapid administration can cause very severe pain.

For babies up to six months old, an intramuscular injection is given into the anterior surface of the thigh (so as not to accidentally damage the sciatic nerve).

For children, especially very young children, all injections are given with saline or water for injection. Injections with novocaine less painful than injections saline solution, however, dilute the drug novocaine is permitted only if there is firm confidence that this will not cause allergic reaction The child has ( novocaine capable of giving the strongest allergies And convulsions).

Like others neurometabolic drugs, Cortexin is recommended to be injected before 12 noon, given its activating effect and ability to provoke psychomotor agitation.

Adult patients are given Cortexin injections once a day, daily for ten days, at a dose of 10 mg.

At massive ischemic stroke(MII) in the acute phase, as well as in the early recovery period, the indicated dose is recommended to be administered to the patient twice a day (morning and evening) for ten days. After ten days, the course should be repeated.

In pediatric practice, the medicine is used to treat children from the first days of their life.

For patients whose weight does not exceed 20 kg, the drug is prescribed at a dose of 0.5 mg/kg body weight. For patients weighing more than 20 kg, a dose of 10 mg is indicated.

The duration of treatment is ten days. If necessary, after three to six months the patient may be prescribed a second course.

The drug extremely rarely causes side effects, has almost no contraindications and can be used to treat even newborn babies. Its main disadvantage is considered to be its release form: Cortexin is not available in tablets, and this partly complicates its use in children, if the latter require several courses.

To date, there are no reports of side effects that have developed as a result of an overdose of Cortexin.

The drug is incompatible with drugs that have a peptide structure.

The drug belongs to the category of prescription drugs and should be dispensed from pharmacies only with a doctor's prescription.

Cortexin should be stored in a dry place, protected from sunlight, at a temperature of 2 to 20°C.

Suitable for use within 36 months from the date of manufacture.

The drug is produced exclusively in the form of a lyophilisate; Cortexin is not produced in tablets.

The drug should not be mixed in the same syringe with any other medications.

Cortexin analogues in tablets: Armadin And Armadin Lon G, Huato Boluses, Borizol, Glitsed, Mexidol, Mexiprim, Glutamic acid, Rilutek, Cytoflavin.

Analogues of Cortexin in ampoules: Armadin, Mexiprim, Neurotropin, Nikomex, Nucleo CMF Forte, Cytoflavin.

Studies conducted on laboratory rats have shown that Cerebrolysin and Cortexin for intraperitoneal administration and injection into lateral ventricle of the brain have a similar effect.

A comparative analysis of the central effects of the drugs led to the conclusion that, despite all their similarities, Cortexin is more active.

At the same time, it provokes a much smaller number of adverse reactions and can be used from birth (whereas Cerebrolysin in pediatric practice it is used if there are justified indications).

According to some patients, injections Cerebrolysin less painful compared to Cortexin injections.

The instructions for use of Cortexin for children permit the use of this drug from the first days of a child’s life.

Reviews from doctors about Cortexin for children confirm the manufacturer’s statements that the drug causes virtually no adverse reactions, allergies, does not provide teratogenic and carcinogenic effects and is well tolerated by patients.

Its use in neurology, neonatology and pediatrics can improve the child’s behavior and his general condition with various types of tones, normalize memory function and speech, and relieve headaches.

Cortexin is a drug widely used in neurological practice. Reviews of Cortexin for adults, which can be found on numerous thematic forums, indicate the effectiveness of this drug for treating patients of all ages (both infants and the elderly).

Taking the drug allows you to speed up the recovery process after injuries and strokes, and in older people it stimulates work brain, increases the ability to remember and concentrate, and also prevents a decrease in intellectual abilities.

Reviews of Cortexin for children allow us to conclude that the drug is most often prescribed to children who have certain deviations in neuropsychic development. In particular, the indications for use of the drug are cerebral palsy And brain damage that occurred in the prenatal period (close to the date of birth) or directly during childbirth.

Injections for children - and reviews of Cortexin confirm this - can achieve significant improvements: after a course of treatment with the drug, the child becomes calmer, he has improved brain activity, an increased interest in learning, and improved memory and speech.

The use of the drug for infants (in particular, for newborns born ahead of schedule) allows you to notice obvious improvements in a fairly short time, which are manifested in the child’s calmer behavior or the emergence of new skills (for example, the ability to independently roll over from his back to his tummy and back).

Mothers whose children were prescribed Cortexin note that after the course of treatment the child literally “came to life before our eyes.” Many consider the advantages of the drug to be the absence of side effects and low toxicity of the drug. The disadvantages most often cited are the rather high price of the product and the pain of the injections.

As for doctors' reviews of Cortexin, they, despite the rather high rating of the drug on forums (an average of 4.1-4.3 on a 5-point scale), are quite contradictory: some doctors consider it a panacea, others - a dummy with unproven effectiveness .

The price of Cortexin 10 mg in Ukraine is 598-685 UAH, the price of Cortexin injections for children varies from 440 to 520 UAH. In Dnepropetrovsk, Zaporozhye, Donetsk and other large cities, you can buy the drug both in a network of retail pharmacies and through online pharmacies with delivery directly to your home.

The average price of Cortexin in ampoules of 5 ml of 10 mg each in Russia is 1100-1200 rubles, the average cost of ampoules of 5 mg is 700-850 rubles.

The drug is not available in tablets.

Cortexin lyophilisate 10 mg 5 ml 10 pcs. Geropharm LLC

Cortexin for children lyophilisate 5 mg 10 pcs. Geropharm LLC

Cortexin 10 mg lyophilisate for injection. injection solution No. 10 bottlesGeropharm LLC

Cortexin 5 mg lyophilisate for injection. injection solution No. 10 bottles (for children) Geropharm LLC

CortexinGeropharm LLC, Russia

Cortexin 5 mg No. 10 pores. d/in.fl.Geropharm LLC (Russia)

Cortexin 10 mg No. 10 pores. d/in.fl.Geropharm LLC (Russia)

represents

nootropic drug, which is also a peptide (protein) bioregulator. Cortexin improves the metabolic process in structures

brain

And due to this, it has a cerebroprotective, nootropic, anticonvulsant and antioxidant effect on the central nervous system.

The drug is used in the complex treatment of traumatic brain injuries, cerebral circulatory disorders, neuroinfections, encephalopathies, encephalitis, encephalomyelitis, epilepsy, vegetative-vascular dystonia, cerebral palsy, delayed psychomotor and speech development in children, as well as disorders of memory, thinking and ability to training.

Currently, Cortexin is produced in a single dosage form - it is a lyophilisate for the preparation of a solution for intramuscular injection. The lyophilisate is placed in 5 ml glass bottles, which are packaged in cardboard boxes of 2, 5 or 10 pieces.

The lyophilisate is a special dried extract of protein fractions obtained from the cerebral cortex of cattle and pigs. It is this peptide extract that is the active component of the Cortexin drug. Each glass bottle contains 10 mg of extract of protein fractions of the cerebral cortex of cattle and pigs.

In addition, on the pharmaceutical market of the CIS countries there was children's Cortexin, the bottles of which contained only 5 mg of lyophilisate of protein fractions of the cerebral cortex of cows and pigs. Apart from the dosage, Cortexin for children and adults are no different.

The lyophilisate contains only the amino acid glycine as an auxiliary component. Externally, the lyophilisate is a powder or a homogeneous porous mass of white or white-yellowish color.

Cortexin contains low molecular weight (small molecules in weight and length) proteins of the cerebral cortex of pigs and cows, which, when administered intramuscularly, are able to penetrate through

blood-brain barrier

and enter the human brain, providing its positive therapeutic effect.

Cortexin has the following therapeutic effects:

• Neuroprotective (cerebroprotective);
• Nootropic;
• Anticonvulsant;
• Antioxidant.

Neuroprotective effect is to protect brain neurons from damage by various unfavorable factors, such as calcium ions, free radicals, oxygen deficiency, etc. Thanks to this, the nerve cells of the brain become resistant to adverse environmental factors, which allows them to function more efficiently. In addition, due to its neuroprotective effect, Cortexin effectively reduces the degree of toxic effects on brain structures of various psychotropic substances (for example, antipsychotics, drugs, etc.).

Nootropic effect Cortexina is to improve the cognitive function of the brain. That is, it becomes easier for a person to study, work, learn new things, etc., since memory, concentration and resistance to stress improve.

Anticonvulsant action lies in the ability to suppress the activity of the pathological focus in the brain and, thereby, prevent the development of seizures.

Antioxidant action is to slow down the process of lipid peroxidation and, thereby, prevent damage to cells of various brain structures by free radicals. In addition, Cortexin increases the survival of brain cells under hypoxic conditions.

In addition to the above effects, Cortexin has tissue-specific action, which consists in activating metabolic and reparation processes in the structures of the brain, thereby improving the functional state and general tone of the central nervous system.

The mechanism of action of Cortexin is ensured by the activation of neurons and neurotrophic factors of the brain, due to which the transfer of information between brain structures occurs much faster and more efficiently. In addition, Cortexin optimizes the balance of inhibitory and excitatory amino acids, dopamine and serotonin in the brain, which reduces seizure activity and improves bioelectric potential.

Cortexin is indicated for use as part of complex therapy for the following conditions and diseases:

• Cerebrovascular accidents;
• Traumatic brain injuries and their consequences;
• Encephalopathy of any origin;
• Cognitive disorders (memory, attention, thinking disorders);
• Acute or chronic encephalitis or encephalomyelitis;
• Epilepsy;
• Asthenia;
• Vegetovascular dystonia;
• Reduced ability to learn and assimilate new things;
• Delayed psychomotor development of children;
• Delayed speech development in children;
• Cerebral palsy;
• Critical conditions of newborns with perinatal damage to the central nervous system.

How to dilute Cortexin

Since the rules for using and breeding Cortexin for children and adults are the same, we will consider them together.

The bottle with lyophilisate (for both children and adults) contains one dose of Cortexin, which is dissolved immediately before the injection, and the resulting ready-made solution is administered intramuscularly. The contents of the bottle can be diluted with the following solvents:

• 0.5% novocaine solution;
• Water for injection is sterile;
• Saline solution, sterile for injection.

Any of the above solutions can be used to dilute the lyophilisate, but it is best to use water for injection or saline. Novocaine is convenient for diluting Cortexin lyophilisate, since it is an anesthetic and somewhat reduces the pain of injections, but, at the same time, increases the risk of allergic reactions and weakens the therapeutic effect of the drug. Therefore, it is recommended to use novocaine for diluting the lyophilisate only if Cortexin injections are too painful and difficult to tolerate for a particular person. If a person can endure a painful injection, then it is better to use saline or water for injection to dilute the lyophilisate, since they do not affect the severity of the therapeutic effect and the likelihood of developing an allergic reaction. These solutions must be purchased separately from pharmacies, since they are not included in Cortexin packages.

To dilute the lyophilisate, it is recommended to purchase solutions of novocaine, physiological or water for injection, bottled in small containers, for example, vials or ampoules. It is optimal to purchase ampoules or bottles of 2 ml or 5 ml in order to use the entire available solution at one time. This requirement is due to the fact that solutions for diluting Cortexin lyophilisate must be sterile, and it is impossible to maintain the sterility of an ampoule or bottle of relatively large volume once opened at home. Therefore, it is better to use a sterile solution for each dilution, previously stored in a hermetically sealed container.

To dilute an adult or children's lyophilisate, 1 - 2 ml of any specified solution is required. Dilution is carried out as follows:

1.

2.

3.

4.

5.

6.

7.

8.

Cortexin lyophilisate should be diluted immediately before making the injection and used immediately after obtaining the solution, since the latter cannot be stored. If for some reason the Cortexin solution was not administered immediately after preparation and stood for more than 20 minutes, then it should be thrown away and the re-diluted lyophilisate from another bottle should be used.

The finished solution of Cortexin cannot be mixed with other medications; it must be administered separately.

Cortexin is administered 10 mg (one bottle of lyophilisate) once a day for 10 days. These dosages and course of treatment are the same for various conditions and diseases, with the exception of ischemic

stroke

If necessary, Cortexin therapy courses can be repeated, maintaining intervals of at least 3 to 6 months between them.

During a stroke and in the rehabilitation period after it It is recommended to administer 10 mg of Cortexin intramuscularly (1 bottle) twice a day for 10 days. Then they take a break for 10 days, and again administer one bottle of Cortexin 2 times a day for another 10 days. Two such courses of treatment with a 10-day break between them are sufficient and complete for treating ischemic stroke and improving rehabilitation after its completion. It is preferable to give injections in the morning and during the day, since administration of the drug in the evening can provoke excessive agitation and difficulty falling asleep. If necessary, the course of Cortexin can be repeated, maintaining an interval of 3 to 6 months between the two subsequent courses.

Children weighing less than 20 kg, the dosage of Cortexin is calculated individually, based on the ratio of 0.5 mg per 1 kg of weight. The calculated dose is administered to the child once a day for 10 days. If necessary, courses of therapy are repeated every 3 to 6 months until the desired result is obtained.

If for any reason an injection of Cortexin was missed, then the next day you should not administer a double dose. It is necessary to administer the usual single dosage of the drug and lengthen the course of therapy so that it consists of 10 injections.

Cortexin injections (injections) are given only intramuscularly. Before the injection, you should choose the optimal place on the body, which includes areas where the muscles come closest to the surface of the skin, such as:

• The anterolateral surface of the thigh in the upper third;
• Outer upper third of the shoulder;
• The anterior wall of the abdomen (in non-obese people).

The buttocks, contrary to popular belief, are not the optimal place for intramuscular injections, since this part of the body has a rather thick layer of subcutaneous fat, into which the drug often gets trapped, which leads to the formation of a lump and slow absorption of the drug into the blood.

Having selected the injection area, you need to treat it with a cotton swab soaked in an antiseptic, for example, 70% alcohol, chlorhexidine, Belasept, etc. Then you should insert the needle into the thickness of the tissue, holding it perpendicular to the surface of the skin. The needle is inserted so that about 3–4 mm of free space remains between the skin and the needle holder. After this, slowly pressing on the piston, release the solution into the tissue and remove the syringe. After the injection is completed, the injection site is wiped again with a cotton swab moistened with an antiseptic.

For each subsequent injection, 1 cm is removed from the mark of the previous injection. That is, there must be a distance of at least 1 cm between the injection marks. All injections required for a course of therapy can be made in the same area of ​​the body, but keeping between them distance 1 cm.

pregnancy

Cortexin is contraindicated because there is no genuine and convincing data on its safety for the fetus and mother.

Cortexin should also not be used when breastfeeding. If for any reason a nursing woman needs to undergo a course of treatment with Cortexin, then she should stop feeding the child for the period of therapy and transfer him to artificial milk formula. One day after the last injection, you can continue breastfeeding if you managed to maintain lactation.

Cortexin does not impair the ability to control mechanisms, but, on the contrary, improves it, therefore, while using the drug, you can engage in any type of activity that requires a high speed of reactions and concentration.

An overdose of Cortexin was never recorded during the entire period of observation of the use of the drug.

Cortexin does not significantly interact with other drugs, so it can be included in complex therapy with any other drugs.

Cortexin in practical healthcare is used for children of any age, including babies under 1 year old. For young children, the drug is most often prescribed to eliminate delays in motor, mental or speech development, with PPCNS (perinatal damage to the central nervous system), as well as for behavior correction, namely, eliminating hysterics,

nervousness

etc. This drug is even popularly called “talkers”, because after a course of Cortexin injections, children quickly begin to speak, quickly and well remember new material, easily retell texts and poems, and their speech becomes clear and varied. Cortexin also helps accelerate motor

child development

As a result, after a course of its use, babies begin to sit up, crawl, stand on their feet, etc.

Cortexin is most often prescribed to school-age children to improve cognitive functions, that is, memory, thinking and attention. As a rule, the drug is given to schoolchildren when it is difficult to master educational material, low learning ability, slurred and monotonous speech, etc. The drug is also prescribed to children of any age to eliminate the consequences of various adverse effects on the brain, such as trauma, hypoxia, stress, etc.

For children weighing 20 kg or more, Cortexin is prescribed in an adult dosage, that is, 10 mg once a day for 10 days. And for children weighing less than 20 kg, the dosage of the drug is calculated individually, based on the ratio of 0.5 mg per 1 kg of weight. The calculated dosage is one-time, that is, this amount of the drug is administered to the child once a day for 10 days. Any Cortexin can be administered to a child - both for children and for adults; it is only important to correctly calculate the amount of solution required for the dose.

Let's look at an example of how to correctly calculate the dosage of Cortexin for a child and convert milligrams of lyophilisate into milliliters of the finished solution.

For example, a child has a body weight of 15 kg, which means he needs 0.5 * 15 = 7.5 mg of Cortexin lyophilisate per injection. Next, you need to decide how many milliliters of solution you will use to dilute the Cortexin lyophilisate, since this is important for further calculations. Let’s assume that 1 ml of solution will be used to dilute the lyophilisate. Then 1 ml of the prepared solution of adult Cortexin will contain 10 mg of lyophilisate. But a child does not need all 10 mg of lyophilisate for injection, but only 7.5 mg. This means that it is necessary to calculate how many milliliters of the finished Cortexin solution, obtained by mixing the entire volume of lyophilisate with 1 ml of solvent, contains only 7.5 mg of the active component. To do this, we create a proportion:

1 ml of solution – 10 mg of lyophilisate;

X ml of solution – 7.5 mg of lyophilisate;

Using the proportion, we make up the equation: X = 7.5 mg * 1 ml / 10 mg; X = 0.75 ml.

This means that 7.5 mg of lyophilisate is contained in 0.75 ml of solution obtained by mixing the entire volume of Cortexin powder present in the bottle with 1 ml of solvent. Thus, to produce an injection, the child will have to dilute the entire lyophilisate in the vial and draw only 0.75 ml into the syringe. The remaining solution should be discarded, and for the next injection, dilute the lyophilisate from a new bottle.

The dosage and volume of the finished solution for injection are calculated in a similar way for a child of any body weight. You can use the given diagram, substituting your own numbers into it. When using children's Cortexin, dosages are calculated in exactly the same way, only taking into account the fact that one bottle of lyophilisate contains not 10 mg of the active substance, but 5 mg.

Parents must remember that the lyophilisate in the vial cannot be divided into parts, you should dilute it all. And only then, from the entire solution, select the volume required for a single administration to the child. The remaining solution should be thrown away and not stored, and for each subsequent injection, the entire lyophilisate from one bottle should be diluted again, the required volume should be taken, administered to the child, etc.

The duration of therapy with Cortexin is 10 days, and it is recommended to give injections in the first half of the day (before 14.00 - 15.00), since the drug has a stimulating effect, as a result of which, when administered in the evening, it can cause difficulty falling asleep. Courses of therapy can be repeated, maintaining intervals between them of 3–6 months, and each time recalculating the dosage based on the child’s actual body weight.

To dilute the lyophilisate for the production of Cortexin injections, children are recommended to use saline solution or sterile water for injection, and not novocaine. The fact is that novocaine can provoke allergic reactions and reduce the severity of the therapeutic effect of Cortexin. For children, it is optimal to dilute adult Cortexin (10 mg) with 1 ml of solvent, and for children – 2 ml.

Cortexin injections for children should be performed strictly intramuscularly according to the same rules as for adults. In addition, to reduce the pain of the injection, it is necessary to take thin needles and inject the solution very slowly, and then, according to the children, they practically do not feel pain.

Cortexin is generally well tolerated and does not cause any side effects. However, in rare cases, the drug can cause various allergic reactions as a side effect (

rashes

etc.). Most often, allergic reactions occur when novocaine is used as a solvent. If the lyophilisate is diluted with saline or water for injection, then allergic reactions almost never occur, unlike novocaine.

Cortexin is contraindicated for use in the following cases:

• Individual intolerance or allergic reaction to the drug;
• Pregnancy;
• Breastfeeding period.

• Amylonosar tablets and solution for injection;
• Acefen tablets;
• Bravinton concentrate for the preparation of solution for infusion;
• Vinpotropil capsules, tablets and concentrate for the preparation of solution for infusion;
• Vinpocetine tablets and concentrate for the preparation of solution for infusion;
• Vinpocetine Forte tablets;
• Vincetin tablets;
• Ginkgo Biloba tablets and capsules;
• Ginkoum capsules;
• Glycine tablets sublingual and buccal;
• Gopantam tablets;
• Demanol solution for oral administration;
• Idebenone capsules and tablets;
• Cavinton tablets and concentrate for the preparation of solution for infusion;
• Cavinton Forte and Cavinton Comforte tablets;
• Calcium hopantenate tablets;
• Carnitex capsules;
• Carnicetine capsules;
• Cogitum solution for oral administration;
• Combitropil capsules;
• Korsavin and Korsavin Forte tablets;
• Lucetam tablets and solution for injection;
• Memotropil tablets;
• Minisem nasal drops;
• Neypilept solution for injection;
• Neuromet capsules;
• Noben capsules;
• NooCam capsules;
• Nooclerin solution for oral administration;
• Noopept tablets;
• Nootropil capsules, tablets and solution for injection;
• Omaron tablets;
• Pantogam syrup and tablets;
• Pantogam active capsules;
• Pantocalcin tablets;
• Picamilon tablets and solution for injection;
• Picanoyl tablets;
• Pikogam tablets;
• Pineamin lyophilisate for the preparation of solution for injection;
• Pyracesin capsules;
• Piracetam capsules, tablets, granules for the preparation of syrup for children, solution for injection;
• Pyriditol tablets;
• Semax nasal drops;
• Telektol tablets;
• Thiocetam tablets and solution for injection;
• Fezam capsules;
• Phenotropil tablets;
• Celestab capsules;
• Cellex solution for subcutaneous administration;
• Ceraxon solution for oral administration and injection;
• Cerebrolysate solution for injection;
• Cerebrolysin solution for injection;
• Encephabol tablets and oral suspension;
• Epithalamin powder for solution for injection;
• Escotropil solution for infusion.

From 2/3 to 3/4 of the reviews about Cortexin are positive, which is due to the immediately noticeable positive effects of the drug. Thus, reviews indicate that after using Cortexin, memory and attention improved, the process of finding solutions to various problems accelerated, and in general any mental work, including very intense work, was much easier. In addition, the efficiency of mental work became higher, and the person spent much less time and effort on solving any abstract or concrete problem.

There are relatively few negative reviews about Cortexin, and they are due to two main factors. Firstly, negative reviews were left by people who did not feel any positive effect after a course of using the drug or who did not get the result they expected. Secondly, negative reviews about Cortexin are due to allergic reactions that arose in response to its administration.

Negative reviews of Cortexin for children are usually due to the development of an allergic reaction to the drug, which forced them to stop treatment. Moreover, allergies, as a rule, developed when novocaine was used as a solvent for diluting the lyophilisate. In more rare cases, negative reviews about Cortexin are due to the lack of a positive effect from its use or the opinion of doctors that the drug is used only in the CIS countries, that it has been poorly researched, etc.

Actovegin and Cortexin are drugs of animal origin with a similar spectrum of therapeutic activity and indications for use. However, according to studies, the effectiveness of Cortexin in the treatment of perinatal damage to the central nervous system and related problems (delayed psychomotor and speech development, etc.) is much higher than that of Actovegin. Accordingly, if you need to choose a drug to eliminate the consequences of hypoxic or traumatic damage to brain structures, it is better to choose Cortexin.

Actovegin is more effective in the treatment of vegetative-vascular dystonia.

In addition, Actovegin can provoke neuro-reflex excitability, but Cortexin does not. Therefore, if a person is excitable, prone to hysterics, nervousness and other similar manifestations, then it is also better to prefer Cortexin.

More information about the drug Actovegin

Treatment of brain dysfunctions is necessarily accompanied by the use of medications. This article will review the instructions for use of Cortexin, a nootropic drug. It has a combined effect, improving metabolic processes in brain structures. A distinctive feature of the development of Russian pharmacists is that Cortexin injections can be used to treat a wide range of central nervous system diseases in pediatrics.

The production of Cortexin is carried out by the company Geropharm LLC. In pharmacies, the drug is sold only in the form of a powder (lyophilisate), ready for dilution and intramuscular administration. Inside the bottle there is a white or yellow suspension. Cortexin injections in 10 ml ampoules are usually used for the treatment of adult patients. Cortexin injections in 5 mg ampoules are produced specifically for use in pediatric practice.

Lyophilisate Cortexin is an extract of protein fractions dried using a special technology, extracted from the brain of cattle and pigs. A 5 ml bottle contains 10 mg of this active substance. In 3 ml bottles, which are used in pediatrics, the concentration of the extract is 5 mg.

Cortexin belongs to the category of prescription drugs, that is, it can only be purchased with a prescription from your doctor. One course of 10 bottles of lyophilisate with a volume of 5 mg will cost between 650 and 900 rubles. The price of the same amount of Cortexin 10 mg is from 1000 to 1200 rubles.

Cortexin contains water-soluble low-molecular polypeptides that easily cross the BBB. Once in the human brain, the active substance has a complex therapeutic effect, which is expressed in a number of effects:

• Nootropic. Cortexin can improve cognitive function of the brain. While taking it, there is an improvement in concentration and memory, and a person will find it easier to cope with stressful situations. The resistance of brain tissue to various harmful factors also increases.
• Neuroprotective. It is expressed in protecting the brain from the damaging effects of free radicals and calcium ions. Cortexin also reduces the toxic effect of psychotropic substances.
• Antioxidant. Manifests itself in the ability of the drug to inhibit the oxidative processes of lipids. Thus, the drug prevents the destruction of brain cells under the influence of free radicals. In addition, Cortexin increases the stability and survival of neurons under conditions of oxygen deficiency. As a result of this effect, the process of destruction of cell membranes slows down, microcirculation returns to normal, and the walls of blood vessels are strengthened.
• Tissue specific. It is expressed in the acceleration of metabolism at the level of neurons of the central nervous system. Cortexin also improves repair processes and normalizes the functions of the cerebral cortex.

In addition to accelerating and improving neural connections, the drug optimizes amino acid balance and increases the synthesis of serotonin and dopamine.

Why are Cortexin injections prescribed? The drug is used as one of the means of complex therapy for the treatment of the following conditions and diseases:

• pathologies of the nervous system;
• circulatory disorders in the brain;
• TBI and its consequences;
• memory impairment;
• encephalopathy of various origins;
• delayed speech and psychomotor development;
• decreased ability to learn and mental development;
• consequences of stroke;
• acute or chronic pathologies of the central nervous system;
• asthenia;
• senile dementia.

Cortexin can also be prescribed for the treatment of critical conditions in children of the first year of life caused by postpartum or intrauterine damage to the central nervous system.

To use the drug correctly and achieve a therapeutic effect, you need to know how and with what to dilute Cortexin. To prepare the medicine, the following solvents are used:

• 0.5% novocaine solution;
• special purified water for injections;
• saline solution for injections.

Novocaine is used to reduce pain from injections, but its use as a solvent increases the risk of side effects such as an allergic reaction. In addition, this anesthetic may reduce the therapeutic effect of the drug. Therefore, it is advisable to use novocaine only if a person has difficulty withstanding injections.

Saline and water for injection are best suited for diluting the lyophilisate. – they do not reduce the therapeutic effect of the active substance and cannot provoke the development of allergic reactions. These solutions must be purchased separately, since they are not included in the kit with Cortexin.

To dilute one bottle of lyophilisate for adults or children, you will need 1-2 ml of solution. The procedure for preparing the medicine is as follows:

• open the ampoule with saline solution or water for injection;
• take a sterile syringe and draw the required amount of solvent;
• pierce the bottle with the drug with a needle, slowly release the solvent into the contents of the bottle along the wall;
• The bottle is gently shaken without removing the needle, ensuring that the powder is completely dissolved in the liquid;
• Draw the prepared solution into the syringe and inject.

Good to know

It is worth noting that the half-life of the active substance is no more than 20 minutes, so the drug must be diluted immediately before the procedure. If the finished solution has stood for more than this time, it cannot be used.

Instructions for use

Cortexin injections are not given intravenously; in medical practice, injections are carried out only intramuscularly. The most suitable places for a puncture are the shoulder area and the anterior lateral surface of the thigh. Injections can also be given to the abdominal area, provided the patient is not obese. It is not recommended to inject the drug into the buttock area. Here the layer of subcutaneous fat is especially thick, and the drug is less absorbed into the blood.

After selecting the injection area, it is necessary to treat the surface with an antiseptic. To do this, you can use a cotton swab soaked in alcohol (70%) or chlorhexidine. The needle must be inserted perpendicular to the surface of the skin, leaving free space (approximately 4 mm) between it and the needle. The solution must be released by slowly pressing on the syringe plunger, after which it must be carefully removed. After the injection, you should re-treat the injection site with an antiseptic. Each subsequent injection should be done at a distance of one centimeter from the previous site.

The dosage is determined based on the patient’s age and body weight. Cortexin for adults and children whose body weight exceeds 20 kg is prescribed in a daily dose of no more than 10 mg. The duration of therapy is 10 days. This is a universal regimen of use and is suitable for the treatment of various conditions and diseases. The exception is ischemic stroke. The need for a repeat course is determined by the attending physician, but intervals of at least 3 months must be maintained between them.

Cortexin for stroke and during the rehabilitation period is used in a standard dosage twice a day. The duration of the first course is 10 days, after which there is a break for 10 days. Then the regimen is repeated in the same dosage and for the same duration. It is best to carry out injections in the morning or during the day, since the drug can contribute to excessive excitability of the central nervous system. If the medicine is administered in the evening, it may cause difficulty falling asleep.

The dosage of Cortexin for children weighing less than 20 kg is calculated individually. According to the standard, 0.5 mg of the drug is taken per 1 kg of weight. The calculated value is a single dose, which is repeated every day for 10 days. In this case, the course therapy can also be repeated 3 months after the end of the first.

If the patient misses an injection of Cortexin, there is no need to administer a double dose the next day. It is enough to administer a single dosage of the drug and increase the duration of therapy - so that it is 10 days.

Many parents are interested in whether Cortexin can be used for children? The drug can be used at any age, including for the treatment of newborns. An absolute contraindication to the use of Cortexin is individual intolerance. Also, due to the lack of clinical data, the drug is not recommended for use during pregnancy and breastfeeding.

Side effects usually occur due to individual intolerance - allergic reactions are possible (for example, atopic dermatitis). If such symptoms occur, Cortexin is discontinued and antihistamines are prescribed. An allergy can be triggered not by the drug itself, but by the solvent novocaine. In this case, the course of treatment with Cortexin is continued, but the anesthetic is changed to injectable water or saline.

Cortexin has a large number of analogues. They have a similar spectrum of therapeutic action. These drugs include the following:

• Actovegin,
• Mexidol,
• Piracetam,
• Tserakson et al.

But it is worth noting that all these analogues contain other active ingredients. Therefore, the list of indications, contraindications and adverse reactions may be different from those of Cortexin.

The use of an analogue is advisable only if injections are impossible or if you have an allergic reaction to the active substance. In this case, only the attending physician can prescribe a replacement for Cortexin.

Cortexin is one of the significant achievements of domestic pharmaceuticals. Lyophilisate is actively used for the treatment various diseases related to the functioning of the brain and central nervous system. Reviews of the use of Cortexin indicate that this is a truly effective drug that can be indispensable in the complex therapy of a number of conditions and pathologies.

Review #1

When my son was still small, we were faced with the fact that he had a delay in psycho-speech development. He perceived information well: he knew letters and numbers, could write them, but did not speak. Plus, we were talking about hyperactivity. All experts offered different solutions. Someone said that there is no need to worry, and there are examples where children only began to talk by the age of four.

Some strongly recommended taking medications, one of which, Cortexin, really helped. The first injection was given at the clinic, and the rest - I did it myself. The injections themselves are painful, so novocaine was used as a solvent. No allergic reactions were observed from him. Already during the course, I noticed that my son became calmer, began to talk, and his vocabulary expanded. Three months later the course was repeated. Cortexin injections really helped.

Olga, Moscow

Since childhood I have suffered from vegetative-vascular dystonia. Frequent dizziness, headaches, weakness, nausea and even vomiting were a common condition for me. Doctors prescribed magnesium supplements, but they didn’t really help me. Last fall, when I once again fainted and received a minor head injury, I decided to undergo a full examination at a paid clinic.

There I was prescribed Cortexin injections and B vitamins. I had to spend 900 rubles (10 bottles) for one course, but they prescribed drugs that were even more expensive. In addition, the effect of using Cortexin began almost immediately and continues to this day. After completing the course, I felt much better: constant weakness, dizziness went away, work and study were easier for me. I used to have at least one fainting spell every six months. A year has passed and I have never experienced such a state.

Ekaterina, Novosibirsk

Six months ago, my daughter began to complain of constant headaches, dizziness and severe weakness. At an appointment with a neurologist, we were prescribed a set of medications, including Cortexin. At first I doubted this treatment, because I needed injections, but the doctor convinced me of the advisability of using the drug.

In addition, it has no adverse reactions and a very short list of contraindications. The medicine cost almost 900 rubles for 10 ampoules. The injections are painful, so they diluted the lyophilisate with novocaine. The injections were carried out in the morning, because Cortexin strongly excites the nervous system. After finishing the course, my daughter became more active, her irritability disappeared, and she stopped complaining about headaches. This also affected her performance at school; it became easier for her to bear the load.

Ulyana, St. Petersburg

Cortexin is a nootropic drug from the group of protein bioregulators.

The action of the drug is based on its ability to normalize metabolic processes in the brain, as a result of which antioxidant, anticonvulsant, nootropic, celebroprotective effects on the central nervous system are observed.

Complexes of low molecular weight water-soluble peptides called cortexin are used as the active component.

Nootropic drug.

Dispensed with a doctor's prescription.

How much does Cortexin cost? The average price in pharmacies is 1,200 rubles.

Cortexin is available in the form of lyophysiate for the preparation of a solution for further injection into the muscle. The drug is available in 5 ml bottles of 10 pieces in a cardboard box with a detailed description attached. The contents of the bottle are a porous white powdery mass with a slight yellowish tint.

• The composition of the lyophilized powder contained in one bottle for the preparation of an injection solution includes 5 or 10 mg of a complex of water-soluble polypeptide fractions (cortexin) as an active substance and 6 or 12 mg of glycine as a stabilizer.

The pharmacological activity of the drug Cortexin is due to the effectiveness of the active ingredients - small proteins by weight, which, after intramuscular infusion, penetrate the brain and contribute to the following positive effects:

1. Antioxidant. The drug slows down the processes of lipid oxidation and prevents the negative effects of free radicals on brain cells. Under the influence of the drug, an increase in cell survival under conditions of oxygen starvation (hypoxia) is observed.
2. Nootropic. Active components improve memory and learning, help increase concentration and resistance to psycho-emotional stress and stressful situations.
3. Neuroprotective effects. The active ingredients help reduce the toxic effects of psychotropic components, as well as protect neurons from a number of neurotoxic factors: calcium ions, free radicals.
4. Anticonvulsant. The drug helps suppress the activity of pathological foci in the brain.

Cortexin also activates metabolic processes, improves the functional state of the central nervous system and increases tone. The drug prevents the formation of free radicals, optimizes the balance of metabolism of excitatory and inhibitory amino acids.

The instructions for use of the drug Cortexin injections indicate that this drug is indicated in the presence or development of the following diseases:

1. Asthenia and encephalitis.
2. Vegetovascular dystonia.
3. Cerebral palsy in children.
4. Cerebral circulation problems.
5. Present traumatic brain injuries, as well as their resulting consequences.
6. Epileptic condition of the patient.
7. Perinatal damage to the central nervous system in children.
8. Cognitive disorders through which a person suffers from memory, attention and thinking disorders.
9. Decreased ability to learn and acquire new knowledge.
10. Problems with speech development in childhood.

The use of the medication has a positive effect on the development of the child, as well as improving the condition of older people.

Like many medications, Cortexin has contraindications:

• pregnancy;
• individual intolerance;
• lactation period;
• hypersensitivity to the components of the drug.

The drug is contraindicated for use during pregnancy (due to the lack of clinical trial data).

The instructions for use indicate: Cortexin in ampoules is administered intramuscularly.

• Before injection, the contents of the bottle are dissolved in 1-2 ml of 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution, directing the needle to the wall of the bottle to avoid foaming, and administered once daily: children weighing up to 20 kg per dose of 0.5 mg/kg, with a body weight of more than 20 kg - at a dose of 10 mg for 10 days.

The drug itself is available in powder form. For intramuscular injections, you should use a special solution. How to dilute Cortexin? The use of lidocaine is not recommended. Only the following liquids can be used:

• 0.5% procaine;
• 0.5% novocaine;
• injection water;
• 0.9% physiological or sodium chloride solution.

Novocaine is an anesthetic, so it reduces the pain of the injection, although it increases the risk of developing allergies. It is better to use water for injection or solution. One bottle of medicine requires 1 or 0.5 ml of liquid. This solution should be taken to treat an adult. For a child, 2 ml of solvent should be used. Although only a doctor can determine the exact proportion.

To dilute an adult or children's lyophilisate, 1 - 2 ml of any specified solution is required. Dilution is carried out as follows:

1. Take a sterile syringe of the required volume and place the needle on the needle holder.
2. Open the ampoule with the solvent.
3. Place the needle into the bottle or ampoule and draw out the required amount of solution (1 - 2 ml).
4. Remove the aluminum foil from the stopper on the bottle with Cortexin lyophilisate (if any).
5. Pierce the rubber stopper on the bottle with the lyophilisate with the needle of the syringe containing the solvent.
6. Lower the needle approximately to the middle of the bottle with lyophilisate.
7. Slowly pressing the syringe plunger release the solvent into the lyophilisate. To prevent the lyophilisate from foaming, it is recommended to point the needle from the syringe at the wall of the bottle, since in this case the liquid will flow evenly down the glass and fall on the powder without blowing it up.

When the entire volume of the solvent has been released into the lyophilisate, it is necessary, without removing the syringe needle, to gently rock the bottle from side to side to ensure complete dissolution of the powder. When the vial contains a homogeneous solution without flakes, this means that the lyophilisate has completely dissolved and can be used for injection.

After complete dissolution of the lyophilisate, it is drawn into a syringe. You can draw up the lyophilisate with the same needle that was used to dissolve the drug, provided that it was not removed from the stopper while the solution was being mixed. If the needle was removed from the stopper of the bottle with the lyophilisate, then to draw the finished solution into the syringe, you should take another sterile needle, since it is this one that will be used for the subsequent injection.

The drug Cortexin does not interact with medications, so it can be used in complex therapy with other medications. The exception is drugs that contain an active substance that has a peptide structure.

We have selected some reviews from people who have taken the drug Cortexin:

1. Nata. Cortexin helped me when I was taking the Unified State Exam, I was thinking about it day and night, I couldn’t get my act together, I didn’t know what object to grab onto. The stress was terrible, but Cortexin helped me get ready and sort everything out. Calms nerves, increases efficiency and organization. I highly recommend it during busy periods at work and school.
2. Veronica. My baby was born with 2-sided hematomas on his head. At the maternity hospital they said: “It’s okay - it will resolve,” and the local pediatrician said the same thing. We came to see a neurologist a month later, and it turned out that we needed to take urgent measures, that cysts could form in the head, etc. She prescribed Cortexin injections as part of a comprehensive treatment. It was very scary to watch how they gave injections to the butt, which was not really there yet, but the baby and I survived. By 7 months, an ultrasound showed that everything was fine with us and we managed to eliminate all the consequences of the birth trauma in time, the cysts had resolved, and the blood circulation in the brain was good. Now the child is one year old, developing according to his age, everything is fine, pah-pah.
3. Oksana. My daughter recently started second grade. The school curriculum was difficult for her. The neurologist prescribed a nootropic drug. I read the reviews about the medicine, the instructions and decided to try it, and the price of the product is low. The treatment began to help after a few days, and the teachers noticed the effect. In addition, my daughter became calmer.

On the domestic pharmaceutical market, Cortexin only has analogue drugs that contain other active substances, but have a similar spectrum of therapeutic activity.

So, the following drugs are analogues of Cortexin:

• Aminalon;
• Ampasse;
• Bilobil;
• Gamma-aminobutyric acid;
• Glycine;
• Glutamic acid;
• Hopantenic acid;
• Idebenone;
• Lutsetam;
• Nootropil;
• Pantogam;
• Piracetam;
• Semax;
• Tenoten;
• Tenoten for children;
• Phenibut;
• Phenotropil;
• Holitylin;
• Cebrilisin;
• Ceraxon;
• Cerebramin;
• Cerebril;
• Cerebrolysate;
• Cerebrolysin;
• Encephabol;
• Escotropile.

Before using analogues, consult your doctor.

Nootropic drug intended for injection. Able to regulate biochemical processes in the body, improve cognitive abilities, protect cells from free radicals and exposure to adverse factors. Prescribed for the treatment of neurological diseases, as well as to prevent the consequences of traumatic brain injuries and other similar conditions. Can be used on patients of any age. Rarely causes adverse reactions.

The drug Cortexin is provided in only one release form - lyophysiate for the preparation of a solution for intramuscular administration. You can buy the medicine in bottles of 5 or 10 mg. The package may contain 5 or 10 ampoules of 3 or 5 ml. Cortexin 10 mg is intended for the treatment of adults. It contains 22 mg of active substance. The drug in a dose of 5 mg is used in pediatrics, is available in 3 ml bottles, contains 11 g of active substance. The bottle of the drug contains white powder with a yellow tint.

Cortexin is a drug from the group of nootropics, with a pronounced neuroprotective, antioxidant and tissue-specific mechanism of action. The basis of the medicine is polypeptides, which are obtained from the cerebral cortex of cattle. The drug also contains glycine, which has a positive effect on the functioning of the central nervous system.

The drug Cortexin belongs to bioregulator drugs with a polypeptide structure. Thanks to the unique composition of the drug, it allows the following effects on the human body:

1. reduces the toxic effects of neurotropic substances;
2. improves blood flow to brain tissues;
3. increases cognitive abilities;
4. improves memory;
5. protects the body from the effects of free radicals;
6. increases concentration;
7. has anticonvulsant properties;
8. helps restore the functioning of the central nervous system.

After administration of the drug, it penetrates into the structures of the brain, protects cells and blood vessels from the negative effects of factors, prevents the death of neurons, provides the brain with oxygen and nutrients, and prevents the development of hypoxia. Multiple clinical trials have shown that therapy with Cortexin improves the tone of the nervous and peripheral systems, improves memory, and reduces the frequency and intensity of headaches. Using the medicine in pediatrics, you can increase the child’s interest in the school curriculum, normalize sleep and concentration.

Cortexin injections are used in complex therapy of neurological diseases in adults and children. For the purpose of prevention or rehabilitation of patients, injections can be prescribed independently.

For patients over 12 years of age and adults, Cortexin can be prescribed for the following diseases and conditions:

• Traumatic brain injuries.
• Post-traumatic conditions and complications.
• Rehabilitation after hemorrhagic or ischemic stroke.
• Encephalopathies of various etiologies.
• Frequent or recurrent headaches.
• Panic attacks.
• Memory impairment.
• Absent-mindedness.
• Forgetfulness in older people.
• Epilepsy.

In pediatrics, injections can be used from birth. High therapeutic activity of the drug is observed when:

• Psychomotor disorders.
• Cerebral palsy.
• Vegetovascular dystonia.
• Delayed speech and mental development.
• Injuries received during childbirth.
• CNS lesions of various etiologies.

The drug should be used for children strictly according to indications and only in a hospital setting under the supervision of medical professionals.

Clinical trials regarding the use of the drug by pregnant women have not been conducted, so there is no such information in the official instructions. During lactation, the use of the drug is possible, but only if the woman switches her baby to artificial formula for the period of treatment.

The instructions for the drug contain information that the drug Cortixin, unlike its analogues, is well tolerated and has virtually no contraindications. Exceptions to taking the medicine are pregnancy, breastfeeding or intolerance to the composition. Despite the minimal number of contraindications, only a doctor can prescribe the drug based on the results of the examination and the final diagnosis.

Before administration, the bottle must be diluted with a solvent (0.5% novocaine, water for injection or 0.9% sodium chloride). The dose is prescribed by the doctor individually. In the process of prescribing the drug, the doctor must take into account the patient’s age, body weight, and final diagnosis.

For adults, Cortexin injections are administered 1 – 2 times a day, for a course of 10 days. If necessary, the doctor may, after a 10-day break, prescribe a second dose of the medication. The instructions for the drug contain standard doses of the drug. So, adults who have suffered a stroke can be prescribed Cortexin at a dose of 10 mg of the drug 2 times a day. For minor neurological disorders, the dose can be reduced to a single dose.

The dose of the medicine depends on the age of the child. Children weighing more than 20 kg are prescribed an adult dose of the drug, 10 mg once a day, for a course of 10 days. For children weighing less than 20 kg, the dose is calculated individually, taking into account 0.5 mg per 1 kg of weight. Newborns and children under 10 years of age can use the drug in 0.5 mg bottles. Therapy with Cortexin can take up to 10 days.

The solution must be diluted before administration. If an adult dose (10 mg) is used, and 5 mg of the drug is indicated for administration, only half an ampoule of the drug should be used. The solution that remains must be disposed of, since it is not suitable for repeated administration.

There is no information in the instructions about prescribing the drug for pregnant women, since the medicine is contraindicated during pregnancy or lactation.

Cortexin is well tolerated, but in rare cases, allergic reactions in the form of skin rash and itching may occur after its administration. As practice shows, adverse reactions appear only when the lyophilisate is diluted with novocaine during the use of the drug. There is minimal risk of side effects when the powder is diluted with 9% sodium chloride.

The drug Cortexin interacts well with other medications. It is intended for complex treatment of neurological diseases in children and adults. It is prohibited to combine the drug solution with other medications in the same syringe. When prescribing several drugs for intramuscular administration, they must be administered with different syringes at intervals prescribed by the doctor.

To properly administer the medication and achieve the maximum therapeutic effect, certain rules must be followed during treatment with Cortexin.

1. The lyophilisate solution must be administered slowly, since rapid administration will cause pain.
2. The medicine must be diluted immediately before its administration.
3. If there is any solution left in the bottle, it should not be reused.
4. When a Cortexin injection is missed for some reason, there is no need to administer a double dose.
5. During the injection process, you must strictly adhere to the rules of antiseptics.
6. The drug does not affect driving a car or working with complex equipment.
7. During the treatment process, the dosage and duration of treatment must be strictly observed.
8. The drug can be used with other nootropics only on the recommendation of a doctor.

By following the basic rules, Cortexin treatment will be effective and completely safe for the patient’s health.

If the recommended dose of the drug is not observed, there is a risk of overdose, but there is no such information in the annotation for the drug. To reduce the risk, during treatment you must strictly adhere to the prescribed dosage of the medication and in no case adjust the dose without consulting a doctor.

You can buy Cortexin injections at any pharmacy in the city without a doctor’s prescription. The medicine should be stored in the refrigerator at a temperature of no more than 8 degrees. Lyophysiat should be stored away from children and sunlight. The shelf life of the drug is indicated on the packaging and each bottle and is 36 months from the date of production. After the expiration date of the medicine, it is not used.

Cortexin can be replaced with the following medications:

1. Combitropil is a domestic combined nootropic drug that contains cinnarizine and piracetam as active ingredients. It has almost the same indications for use. The drug is available in capsules that can be prescribed to patients over 5 years of age.
2. Aminalon belongs to the Cortexin substitutes in the pharmacological group. The drug has been approved for use since one year, but it is not very convenient to give it, since it is available in tablets. Aminalon is contraindicated in the first trimester.
3. Gliatilin is a nootropic drug. It is available in capsules for oral administration and injection solution. Its active component is choline alphoscerate. Gliatilin is an original drug that has proven its effectiveness in treating head trauma, cerebrovascular accidents, and emotional lability. It is contraindicated for children, pregnant women and breastfeeding women.
4. Lucetam is a substitute for the drug Cortexin in the clinical and pharmacological group. Its active ingredient is piracetam. The drug is available in tablets (can be taken from 8 years old) and injections (allowed from 3 years old)

The cost of Cortexin is on average 906 rubles. Prices range from 690 to 1276 rubles.

Cortexin - instructions for use, analogs, reviews and release forms (injections in injection ampoules (lyophilisate) 5 mg and 10 mg) of a drug for the treatment of encephalopathy in adults, children (including newborns) and during pregnancy

In this article you can read the instructions for use of the drug Cortexin.

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Cortexin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Cortexin in the presence of existing structural analogues. Use for the treatment of encephalopathies and cerebrovascular accidents in adults, children (including newborns), as well as during pregnancy and lactation.

Cortexin is a nootropic drug.

Contains a complex of low molecular weight water-soluble polypeptide fractions with a molecular weight of no more than Yes, isolated from the cerebral cortex of cattle or pigs no older than 12 months of age. Penetrates through the BBB directly to nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.

Improves higher brain functions, learning and memory processes, concentration, and resistance to various stressors.

Protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

Inhibits lipid peroxidation in neurons, increases the survival of neurons under conditions of oxidative stress and hypoxia.

Activates the metabolism of neurons in the central and peripheral nervous system, reparative processes, helps improve the functions of the cerebral cortex and the general tone of the nervous system.

The complex composition of Cortexin, the active substance of which is a complex of polypeptide fractions, does not allow for conventional pharmacokinetic analysis of individual components.

In complex therapy of the following conditions and diseases:

• cerebrovascular accidents;
• traumatic brain injury and its consequences;
• encephalopathy of various origins;
• cognitive impairment (including memory and thinking disorders);
• acute and chronic encephalitis and encephalomyelitis;
• epilepsy;
• asthenic conditions;
• suprasegmental autonomic disorders (vegetative-vascular dystonia);
• decreased learning ability;
• delayed psychomotor and speech development in children;
• critical conditions of newborns with perinatal damage to the nervous system;
• various forms of cerebral palsy.

Lyophilisate for the preparation of a solution for intramuscular administration (injections in injection ampoules) 5 mg and 10 mg.

There are no other forms of release, including tablets or capsules. Perhaps these are fakes.

Instructions for use and dosage

The drug is administered intramuscularly.

For children weighing less than 20 kg, the drug is administered at a dose of 0.5 mg/kg body weight, for children weighing more than 20 kg - at a dose of 10 mg per day for 10 days.

If necessary, repeat the course after 3-6 months.

Rules for preparing the solution

The contents of the bottle are dissolved in 1-2 ml of 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution.

• individual hypersensitivity to the components of the drug.

• pregnancy;
• lactation period (breastfeeding);
• individual intolerance to the drug.

Use during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy due to the lack of clinical trial data.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped (due to the lack of clinical trial data).

Drug interactions with Cortexin have not been described.

Analogues of the drug Cortexin

The drug Cortexin has no structural analogs of the active substance. However, there is a large class of nootropic drugs with a similar mechanism of action. Drugs of this type are:

Source: by application:

Latin name: Cortexin

Active ingredient: Polypeptides of the cerebral cortex of cattle

Manufacturer: Geropharm LLC, Russia

Description current as of: 10/23/17

Price in online pharmacies:

Cortexin is a nootropic drug that has a tissue-specific effect on the cerebral cortex due to its optimally balanced composition of neurotransmitters and polypeptides.

Polypeptides of the cerebral cortex of cattle.

Cortexin is available in the form of a lyophilisate for the preparation of a solution for intramuscular administration. The drug is sold in bottles (3 ml each), placed in blister packs of 5 pcs.

Cortexin for children and adults can be prescribed for:

• Neuroinfections of a viral and bacterial nature.
• Traumatic brain injuries.
• Cerebral circulation disorders.
• Asthenic syndrome.
• Complex therapy of epilepsy.
• Encephalopathies of various origins.
• Complex therapy of encephalitis and encephalomyelitis.
• Cerebral palsy.
• Suprasegmental autonomic disorders.
• Delayed speech and psychomotor development.
• Decreased learning ability.
• Impaired memory and thinking.

Contraindications to the use of this drug are: a history of allergic reactions to Cortexin, patient intolerance to other components of the drug, pregnancy and lactation.

The drug is intended for intramuscular administration.

Before injection, the contents of the bottle are dissolved in 0.5% solution of procaine (novocaine), 0.9% solution of sodium chloride or water for injection, directing the needle to the wall of the bottle to avoid foaming. The drug is administered once every day: for children with a body weight of up to 20 kg at a dose of 0.5 mg/kg, with a body weight of more than 20 kg and for adults - at a dose of 10 mg for 10 days.

If necessary, repeat the course months later.

The use of the drug Cortexin may cause side effects in the form of a hypersensitivity reaction.

There are no reports of cases of drug overdose.

Analogs by ATC code: Amylonosar, Vinpotropil, Glycine, Divaza, Omaron.

Do not decide to change the drug on your own; consult your doctor.

Cortexin has nootropic, neuroprotective, tissue-specific and antioxidant effects.

The nootropic effect of the drug lies in its ability to improve higher brain functions, concentration, memory, facilitate learning processes, and develop resistance to various stressful influences.

The tissue-specific effect of the drug lies in its ability to activate the metabolism of neurons in the peripheral and central nervous systems. In this regard, with the use of Cotrexin, patients experience an improvement in the functions of the cerebral cortex and the state of the nervous system as a whole.

The neuroprotective effect of the drug is aimed at protecting neurons from the effects of various neurotoxic and endogenous factors. Thus, this drug reduces the toxic effect of various psychotropic substances.

As for the antioxidant effect of the drug, it comes down to preventing or slowing down lipid peroxidation in neurons. Thus, the use of Cortexin promotes the survival of neurons under hypoxia and oxidative stress.

When using a 0.5% procaine solution, you should adhere to the information about age restrictions, precautions, and contraindications set out in the instructions for use.

The bottle with dissolved powder cannot be stored or used after storage. It is also not recommended to mix it with other solutions.

If an injection is missed, do not administer a double dose, but give the next injection as usual on the scheduled day.

The drug is contraindicated for use during pregnancy.

If it is necessary to prescribe Cortexin during lactation, you must stop breastfeeding.

Application is possible according to the dosage regimen.

Drug interactions

Drug interactions with Cortexin have not been described.

Dispensed by prescription.

Store out of reach of children, protected from light at a temperature not exceeding 25 °C. Shelf life - 3 years.

Cortexin price for 1 package from 729 rubles.

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

Cortexin for children lyophilisate 5 mg 10 pcs.

Cortexin 5 mg lyophilisate for injection. injection solution No. 10 bottles (for children)

Cortexin lyophilisate for intramuscular administration 5 mg n10 vials

Cortexin 10 mg lyophilisate for injection. injection solution No. 10 bottles

Cortexin lyophilisate for intramuscular administration 10 mg n10 vials

The second time a doctor prescribed Cortexin to my father was after he suffered a stroke. The drug helped restore brain activity and, in combination with therapeutic methods, returned full speech to my father.

When using materials from the site, the active reference is obligatory.

The information presented on our website should not be used for self-diagnosis and treatment and cannot serve as a substitute for consultation with a doctor. We warn you about the presence of contraindications. Specialist consultation is required.

Latin name: Cortexin
ATX code: N06BX
Active substance: Polypeptides
cattle cerebral cortex
Manufacturer: Geropharm, Russia
Dispensing from the pharmacy: On prescription
Storage conditions: t from 2 to 20 C
Best before date: 3 years.

Under the influence of Cortexin, activation of regulatory peptides is observed. The drug has a pronounced nootropic, neuroprotective and strong antioxidant effect.

Indications for use

The use of a medicine such as Cortexin is indicated for:

• NS ailments caused by viruses and bacteria
• Brain pathologies of vascular origin
• A number of conditions characterized by impaired cerebral circulation
• Rehabilitation period after TBI
• Diagnosing cerebral autonomic disorders
• Signs of the syndrome of diffuse damage to brain tissue of various origins.

The drug can be used with other drugs for the complex treatment of epileptic seizures and various inflammatory diseases of the brain and spinal cord.

For children, drugs are prescribed for memory and thinking disorders, and a decrease in the level of information perception. The drug is effective for cerebral palsy, inhibition of speech and general psychomotor development.

Composition and release forms

Cortexin (injections) contains a complex of specific polypeptide fractions that are highly soluble in water. In 1 fl. contains 5 or 10 mg of this substance. The description of the drug indicates that the lyophilisate contains another component - glycine.

Cortexin for children and adults is presented as a lyophilized powdery or porous mass of a milky or creamy shade. The medicine is dispensed in bottles of 3 ml and 5 ml; inside the pack there are 10 bottles with lyophilisate.

It is worth noting that Cortexin is not currently produced in tablets.

Medicinal properties

The drug Cortexin is a whole complex of various polypeptides that are highly soluble in water.

Water-soluble polypeptides pass through the blood-brain barrier and then enter the nerve cells themselves. The drug has a nootropic, tissue-specific, antioxidant, as well as a pronounced neuroprotective effect.

The nootopic effect is manifested by improved brain function, increased perception and reproduction of information, and normalized memorability. This increases the body's resistance to stress.

Antioxidant activity is manifested by stopping fat peroxidation inside nerve cells. In addition, the drug helps to increase the viability of the neurons themselves in the event of impaired oxygen supply or oxidative stress.

The tissue-specific effect is due to the activation of the metabolism of nerve cells in the peripheral nervous system and central nervous system, the acceleration of recovery processes. The drug normalizes the tone of the nervous system and is prescribed for diseases of the brain, as it normalizes its functioning.

The neuroprotective effect is manifested in the formation of specific protection of nerve cells from possible damage by endogenous neurotoxic factors, while the negative impact of various psychotropic drugs is significantly reduced.

The mechanism of action is based on the activation of peptides of nerve cells, as well as a number of neurotrophic factors, while optimizing the balance of both inhibitory and stimulating amino acids, serotonin, and dopamine. Under the influence of active substances, the indicator of convulsive activity of brain cells decreases, and BEA is normalized. The drug prevents the formation of free radicals.

At the moment, it has not been possible to identify the pharmacokinetic properties of the drug, since the duration of the decay period of the components of Cortexin, optically active amino acids, and neuropeptides is about 3 minutes. That is why it is not possible to determine the rate, as well as the level of absorption of peptide components, and their possible distribution.

Cortexin: complete instructions for use

Price: from 684 to 1388 rubles.

The drugs are administered only intramuscularly.

How to properly dilute lyophilisate

Before use, the powder mixture in the bottle will need to be dissolved with prepared water, novocaine solution or 0.9% saline solution to the required volume. It must be remembered that the needle must be directed directly to the wall of the bottle, thus preventing the formation of small bubbles in the injection solution.

The drug is administered once a day. Cortexin is administered to adults at a dosage of 10 mg over the next 10 days.

If necessary, repeat the treatment course after 3-6 months. When diagnosing hemispheric ischemic stroke, inject the medicine at a dose of 10 mg. It is worth noting that the course of application is 10 days, then a repeat course is indicated after 10 days.

How to inject drugs into a child

The medicine can be injected into Decam from birth.

After diluting the lyophilisate with water or saline, shake the bottle thoroughly and draw the prepared solution into a disposable syringe.

The drug will need to be administered as slowly as possible; rapid administration may cause pain.

Children up to 6 months. IM administration of the drug is carried out in the front of the thigh, thus preventing accidental damage to the sciatic nerve.

For young children, injections are given using a solution of saline or water. It is worth noting that injections with Novacaine are not so painful, but they can only be done if there is no allergic reaction to it.

Like other neurometabolic drugs, it is preferable to inject Cortexin during the first half of the day, as it can have an activating effect and cause psychomotor agitation.

Cortexin for children weighing up to 20 kg (including infants): administration of drugs should be carried out in a dosage of 0.5 mg of drugs per 1 kg; for a body weight exceeding 20 kg, a drug dosage of 10 mg is indicated. Treatment with Cortexin lasts 10 days, and after the course you will need to conduct an examination to determine the effectiveness of therapy.

Contraindications and precautions

Before injecting a medicine into a child or adult after dilution, you should make sure whether there is hypersensitivity to the components or not.

The medicine should be used only on the recommendation of the attending physician.

You cannot use a 0.5% solution of procaine to make an injection solution.

The finished medicine cannot be saved for later use. The drugs are not mixed with other solutions.

If you miss the next injection, you should not administer a double dosage of the drug; it is recommended to inject it as usual, according to the regimen prescribed by your doctor.

The drug does not affect the ability to operate precision machinery or vehicles.

Cross-drug interactions

Medicines cannot be used simultaneously with drugs that have a peptide structure.

Side effects

The most common adverse reactions are allergic manifestations, which are associated primarily with increased susceptibility to the components of the lyophilisate.

Overdose

Cases of overdose with Cortexin have not been reported.

Analogs

You can replace Cortexin with analogues; your doctor will help you choose both cheaper and more expensive substitute drugs. It must be taken into account that the drug is prescribed taking into account the type of disease and the nature of the pathological process.

EVER Neuro Pharma, Austria

Price from 1007 to 3680 rub.

The drug has a specific effect on neurometabolic processes that occur in the brain. The main component is a peptide complex, which is obtained from raw materials of animal origin - pig brain. Cerebrolysin is indicated for use in cases of head injury, the development of pathologies after a stroke, and NS disorders. It is made in the form of a solution for giving injections.

Pros:

• Indicated for mental disorders
• Used in pediatrics
• Improves higher brain functions.

Minuses:

• Not prescribed for epilepsy
• Shortness of breath may occur during treatment
• Possible increase in seizure activity.

Microgen, Russia

Price from 229 to 552 rub.

Cerebrolysate is a nootropic agent that increases the brain's resistance to hypoxia, normalizes memorability and perception of information, and helps normalize metabolic processes. The therapeutic effect is ensured due to the manifestation of the properties of the active component, namely the hydrolyzate of cattle brain. Prescribed for encephalopathy, myelopathy, neutropathy, ischemic stroke. Cerebrolysate is produced in the form of a solution for injection.

Pros:

• Improves general condition after hemorrhagic stroke
• The drug is used in neuropediatric practice
• Allows you to improve cognitive abilities.

Minuses:

• Not prescribed for pregnant and lactating women
• Do not use in combination with antidepressants
• Use with caution for epilepsy.

Biologische Heilmittel Heel, Germany

Price from 742 to 17098 rub.

Phyto-based drugs regulate metabolic processes. Recommended for use in cases of neurological disorders, hypovitaminosis, and joint pathologies. The composition of the medicinal solution includes plant coenzymes and ascorbic acid.

Pros:

• Eliminates tissue hypoxia
• Activates protective reserves
• Shows antioxidant properties.

Minuses:

• To achieve a visible therapeutic effect, it is recommended to use it in combination with other drugs.
• Expensive
• Local swelling may occur after the injection.

Ferrer International, Spain

Price from 618 to 1855 rub.

The drug helps eliminate the observed cognitive impairment and stimulates the process of restoration of damaged brain tissue after a stroke. The mechanism of action of the drug is due to the specific properties of the main component - citicoline. Ceraxon is recommended for use in complex therapy for vascular disorders of the brain, to speed up recovery after TBI. The release form of Ceraxon is a solution.

Pros:

• Used for vascular diseases of the brain
• Helps eliminate chronic brain hypoxia
• Highly effective in restorative therapy after ischemic stroke.

Minuses:

• May cause hallucinations
• Should not be used concomitantly with medications containing meclofenoxate
• Contraindicated in case of fructose intolerance.