Macmiror complex instructions for use of the tablet. Macmiror: composition, release form, therapeutic activity and distribution in the body

The drug Macmiror has broad-spectrum antibacterial properties. The active substance Nifuratel has bactericidal and antifungal properties. The scope of application is quite diverse, therefore, for complete familiarization, you should study the instructions for use of the medicine in detail.

The action of the drug is based on the activity of the main component of the nitrofuran series, which provides the main pharmacological property of Macmiror. The medicine suppresses the development of fungi of various origins and has a depressing effect on the vital activity of amoebas and giardia.

Macmiror is metabolized in the liver, kidneys, and tends to pass into breast milk in small quantities. The process of complete disintegration and removal of the substance from the body takes place within 5–6 hours.

The composition of the medicine consists of the active substance and auxiliary components.

Main components of the drug:

• nifuratel in the amount of 0.2 grams;
• magnesium stearate;
• magnesium carbonate;
• starch;
• polyethylene glycol;
• titanium dioxide;
• fructose;
• wax.

The drug is produced in the form of white tablets coated in sugar. The blister contains 10 pieces. The cardboard box includes 2 blisters.

Purposes, contraindications, side effects of Macmiror

Macmiror is prescribed for extensive indications for use.

Basic conditions for using the drug:

The medicine has virtually no contraindications, which is a big advantage of the drug. You should not take Macmiror if you are hypersensitive to the active substance.

Side effects may occur when using the medicine:

• state of nausea;
• allergic manifestations (atypical itching, urticaria);
• stomach ache;
• spasms, gag reflex.

Instructions for using Macmiror

The best way to use the medicine is to comply with all dosages prescribed by your doctor in each individual case.

According to the official instructions, the medication and dosage are distributed as follows:

Certain data on drug overdose have not been studied. The drug is dispensed at the pharmacy only with a prescription. The shelf life is 5 years. The use of Macmiror after the expiration date is strictly prohibited! Storage conditions at a temperature of no more than 25 degrees in a dry, dark place, protected from children.

Additional instructions and analogues of Macmiror

No negative interactions with the drug were identified. The combination of nystatin with Macmiror causes excessive activity of the drug. Concurrent use of the substance and alcohol is contraindicated, as side effects may occur.

During pregnancy and breastfeeding, the prescription of Macmiror should be supervised by a doctor, because the active substance is actively absorbed into the bloodstream and passes into breast milk. During lactation, doctors recommend not using the drug.

The average cost of the drug ranges from 800–900 rubles per package. The pricing of the drug is quite high, so to get an alternative, you should consider cheaper analogues of Macmiror. The list below contains close substitutes for the original.

It is worth noting that Macmiror has a sufficient number of analogues that are similar in the structure of action and pharmacological composition. But it is necessary to replace the main drug after consulting a qualified specialist and studying possible side effects and contraindications.

Reviews from the doctor and those who took the drug

Obstetrician-gynecologist in Moscow:

When studying a large number of reviews about the drug Macmiror, one can come to the conclusion that most of them are positive. Quality and popularity depend on professional, consumer-type responses, so below are some recommendations.

I have been working in the gynecological field as an obstetrician-gynecologist for quite a long time. My review of the drug Macmiror was assessed from a professional point of view. Since I mainly care for pregnant women, I often prescribe medicine for preventive purposes before the onset of labor.

The active substance Macmiror allows you to delicately fight the causative agents of various infections and has a positive effect on restoring the proper microflora of the vagina. Another advantage of the medication is the short-term use of the drug, which is especially important during pregnancy. Therefore, I consider this medicine to be one of the optimal and relatively safe antibacterial agents. When prescribing, I take into account all the nuances, so my patients do not feel negative consequences after using Macmiror!

Natalya, Severodvinsk:

Two weeks later we completed a follow-up study and Giardia was no longer detected. I am very glad that we chose the right medicine and quickly got rid of this terrible diagnosis. Macmiror fully pays for the money spent on it, as it ensures the high effectiveness of the drug.

Irina, Orel:

While on vacation, I felt discomfort in my lower abdomen. I felt an unpleasant itching and nagging pain. After visiting a gynecologist and undergoing tests, a diagnosis of vulvovaginitis was made. I was prescribed a course of Macmiror for 10 days in the amount of 3 tablets per day.

After using the drug, I did not notice any significant changes in the body. And after a few days, all the unpleasant moments of the gynecological infection disappeared. After a control test, there were no signs of infection. Therefore, I recommend Macmiror as an effective and high-quality drug with quick effects!

Victor, Kansk:

It all started when I felt severe pain in my lower back. After a clinical urine test, the doctor confirmed the presence of pyelonephritis and kidney inflammation. I was scared by this diagnosis, but the specialist reassured me that the disease can be quickly treated with the use of an effective medicine. This drug turned out to be Macmiror. After taking the first tablet I quickly felt relief, and after a day the pain disappeared.

Complete treatment with Macmiror had a positive effect; there were no serious contraindications to the body. I was very pleased with the medicine and did not regret buying and using the drug. The high price confirms the quality of McMirror!

Macmiror is an antibiotic of synthetic origin of the nitrofuran group. Intended for use in gynecology (complex) and gastroenterology. It has antibacterial, antiprotozoal and antifungal properties. Due to its low toxicity, the drug can be prescribed to children and expectant mothers. The main advantage of the main component is its selective ability to pathogenic microorganisms. In this case, treatment is accompanied by the restoration of the internal ecosystem and the growth of populations of beneficial bacteria. Before using Macmiror, read the instructions for use.

Regardless of the form of release produced, the drug Macmiror contains the main component - nifuratel. The dosage and method of administration allow the drug to be used for various diseases by patients of different age categories.

Macmiror tablets contain 200 mg of the main component, have a white color, a biconvex shape and a sweetish taste of the shell. The cardboard package contains two blisters of 10 pills.

Macmiror suppositories are available in the form of a complex of suppositories. The main component in them is 500 mg. Excipients: nystatin. The shape is oval, the color is light yellow with a brown tint. The consistency is soft jelly-like. Macmiror is produced in the form of a complex of suppositories of 8 or 12 pieces in one package, designed for one course of treatment.

The cream (ointment), as well as Macmiror suppositories, contains nystatin. The active ingredient is 100 mg per 1 g of the drug. Tubes are available in 30 g. The color is yellow. The size of one candle corresponds to 2.5 g of creamy mass.

Mechanism of action

The medicinal effect of Macmiror extends to gram-positive and gram-negative strains of bacteria resistant to other antibiotics. The drug also has a detrimental effect on protozoan microorganisms and some types of fungi. Does not cause resistance.

The high effectiveness of Macmiror is due to the complex of active substances included in its composition. The antimycotic effect of nifuratel is enhanced by the support of nystatin. This tandem has a destructive effect on cell membranes, penetrates inside and disrupts their morphological structure, resulting in the death of pathogenic microorganisms.

Macmiror complex cream or suppositories inhibit only harmful bacteria and fungi, while it does not have a negative effect on beneficial microflora. Nifuratel contained in tablets, when taken orally, is quickly absorbed through the gastrointestinal mucosa and easily overcomes the placental and blood-brain barriers. Some concentrations are found in breast milk.

Macmiror is metabolized in the liver and muscle tissue. It is excreted mainly by the kidneys. Moreover, with urine, approximately 30-50% of the drug composition leaves the body unchanged.

Therapeutic purposes

A synthetic drug consisting of a complex of active substances with bactericidal effects was created for the treatment of diseases caused by acid-dependent bacteria and associated with Helicobacter pylori Macmiror is successfully used for giardiasis and mixed microbial infection.

Macmiror's main indications:

• Diseases of the gastrointestinal tract associated with Helicobacter.
• Vulvovaginal infections caused by Trichomonas, chlamydia, Candida fungi.
• Infectious infections with intestinal protozoa - Giardia, amoeba.
• Infections of the genitourinary system – urethritis, cystitis, pyelitis, pyelonephritis.

For the treatment of gastroenterological diseases, only Macmiror tablets are used; the complex composition is not prescribed in these cases.

Contraindications and negative effects

Macmiror during pregnancy is prescribed only if absolutely necessary. It is taken into account that the infection can cause serious consequences for the mother, so taking an antibiotic is indispensable. At the same time, the danger when using it for a child in the womb is much less.

Also, the influence of Macmiror is transmitted through mother's milk. Therefore, if treatment with this medicine is necessary, it is better to stop lactation.

According to the annotation, Macmiror has contraindications for:

• High sensitivity to the active components of the drug and its auxiliary ingredients.
• Severe renal and hepatic pathologies.
• When planning to conceive a child for men (nifuratel affects spermatogenesis).
• Childhood.

Although Macmiror is a low-toxic drug, side effects may still occur during therapy. They occur both with oral or vaginal use, and with local use.

Negative manifestations:

• Allergic – skin dermatitis, urticaria, itching, swelling.
• Gastrointestinal tract disorders – abdominal pain, nausea, belching, heartburn, bitterness in the mouth, stool disorders.
• Anaphylactic shock, Quincke's edema.

Macmiror, due to its gentle effect on the human body, can be prescribed as a prophylactic agent. But any use of it must be agreed with a doctor, who will help you choose the right dosage and determine the required duration of therapy.

Methods of administration and dosage

The size of a single dose and the duration of treatment are influenced by the individual characteristics of the patient and the severity of the disease. The choice of the dosage form of Macmiror depends on the location of the infection and the type of pathogen.

Pills

The drug does not contain nystatin. Macmiror is prescribed according to the disease according to the following scheme:

• Intestinal infections. Take 2 pills of 200 mg up to 3 times a day. The course of therapy can last up to 10 days. Children's dosage is calculated based on the child's body weight. For 1 kilogram of weight, 10 mg of the substance is used. The result obtained is divided by 3.
• Diseases of the gastrointestinal tract. Prescribe 2 tablets of 200 mg 3 times a day. The course lasts a week. For children, the calculation unit increases - 15 mg per kilogram of weight. They also use Macmiror for Giardia.
• Diseases of the urinary system. A single dose is 0.4 g 3 times a day. Treatment is extended to 2 weeks. Children's dose - 15 mg/kg, divided into 2 doses.
• Sexual infections. Three doses of 200 mg per day. If necessary, treatment is supplemented with cream or vaginal suppositories. Both sexual partners need to undergo therapy. For children, the calculation is based on the treatment plan for gastrointestinal diseases.

In case of an advanced situation or severe disease, the use of Macmiror can be extended or a second course taken. To do this, you need to consult with your doctor.

Suppositories

Despite the low toxicity, the use of Macmiror complex during pregnancy is allowed only as prescribed by a doctor. The drug in the form of suppositories has a systemic effect, since it contains nystatin. Treatment of vaginitis lasts from 8 to 12 days.

Macmiror candles are used as follows:

• Complex 8 is prescribed for mild infections. Suppositories are inserted into the vagina as deeply as possible. The procedure is performed once a day before bedtime. The duration of therapy is 8 days.
• Complex 12 is used for more severe clinical symptoms. Candles are used before bedtime, one per day. Treatment lasts 12 days.

Complex 8 and 12, if necessary, can be repeated at the end of the menstrual period.

Vaginal suppositories are not used to treat young girls to avoid damage to the hymen.

Cream

For this form, the drug is equipped with a special graduated syringe. It is used for the convenience of intravaginal administration of Macmiror. A single dosage is 1 full filling of the applicator, which corresponds to 2.5 mg or 1 suppository.

Therapy is carried out according to the same scheme as for Macmiror suppositories, and is prescribed for the treatment of vaginal infections.

Macmiror is an antiseptic and antibacterial drug. The main active ingredient of the drug, nifuratel, belongs to the nitrofuran antibiotic series.

The drug has an effect on a huge range of microorganisms, including the protozoa of some fungi.

In this article we will look at why doctors prescribe Macmiror, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Macmiror can be read in the comments.

Composition and release form

Tablets are available in blisters, 10 pieces in one. The pack consists of two blisters. The color of the tablets is white. Thanks to the sugar shell, the taste of the drug is sweet.

• A tablet of the drug contains the active substance (nifuratel) - 0.2 grams + excipients (talc, starch, magnesium stearate, polyethylene glycol, gelatin, magnesium carbonate, gum arabic, wax, titanium dioxide, sucrose).

Pharmacological action: antibacterial.

What does Macmiror help with?

Vaginal suppositories (suppositories) Macmiror are broad-spectrum antimicrobial drugs. Therefore, they are successfully used for the treatment of gynecological diseases. Among them:

• vaginal candidiasis,
• bacterial infections that develop in the urogenital area,
• urogenital trichomoniasis.

In addition, practice has shown that Macmiror suppositories cope well with chlamydial infections.
Macmiror tablets are prescribed to patients for the treatment of the following pathologies:

1. Intestinal amoebiasis;
2. Giardiasis;
3. Chronic inflammatory processes of the mucous membranes of the digestive tract caused by the bacterium Helicobacter pylori;
4. Inflammatory and infectious diseases of the genitourinary system - pyelonephritis, pyelitis, cystitis, urethritis, trichomoniasis, chlamydia, vaginal candidiasis.

Pharmacological action

Macmiror tablets have broad-spectrum antimicrobial activity. The medicine has antifungal and antiprotozoal effects. Despite the affordable cost of the drug, it is practically non-toxic and highly effective. Thanks to this, the medicine has a wide range of clinical indications.

Macmiror is effective for eliminating atypical enterobacteria and protozoa such as Giardia and Amoeba. This drug is prescribed for bacterial infections, and in particular for salmonellosis and shigellosis. It is widely used in the fight against fungi of the genus Candida.

Instructions for use

According to the instructions for use, the daily dose of the drug is determined by the doctor individually for each patient and depends on the diagnosis. According to the instructions, tablets are prescribed to patients according to the following scheme:

• For infections caused by Helicobacter pylori, adults are prescribed Macmiror 400 mg (2 tablets) 2-3 times a day; For children, the recommended dose is determined at the rate of 15 mg/kg body weight 2 times a day. Duration of treatment – ​​7 days.
• Intestinal amebiasis is treated in the following way: two tablets after meals (this is 400 mg) twice or thrice a day. Treat for ten days. Children are prescribed Macmiror 10 mg per kilogram of weight.
• Giardiasis. For adults - the same dosage as for gastritis or amoebiasis. Fifteen mg are prescribed per kilogram of weight. They are treated this way for a week.
• For urinary tract infections in adults, depending on the severity of the disease, the drug is prescribed 600-1200 mg (3-6 tablets)/day for 7-14 days. For children, the recommended dose is 30-60 mg/kg/day in 2 divided doses. On the recommendation of a doctor, the course of treatment can be extended or repeated.
• For vaginal infections, adults: 200 mg (1 tablet) 3 times a day for 7 days (both sexual partners should take the drug). For children, the recommended daily dose is 10 mg/kg/day in 2 divided doses daily for 10 days.

For children over 10 years of age, the daily dose is calculated on the basis of 0.01 grams per kg of body weight and is divided into 2 doses per day.

Contraindications

Increased sensitivity to one of the components of the drug.

Side effects

1. Allergic reactions - skin rash, itching, peeling, redness;
2. Stomach ache;
3. Nausea, bitterness in the mouth;
4. Heartburn;
5. Diarrhea;
6. Sometimes vomiting.

Pregnancy and lactation

Use during pregnancy is possible only under strict indications, when the expected benefit to the mother outweighs the potential risk to the fetus, because nifuratel penetrates the placental barrier.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided, because nifuratel is excreted in breast milk.

Analogues

• Analogue in tablets: furazolidone.
• Analogues, ointments and suppositories: Macmiror Complex, Vokadin, Hexicon, Osarbon, Chlorhexidine, Betadine, Ecovag, Iodoxide.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of MAKMIROR in pharmacies (Moscow) is 800 rubles.

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An antibacterial drug from the nitrofuran group is Macmiror. Instructions for use indicate that 200 mg tablets, cream and suppositories as part of the complex have antiprotozoal, antibacterial and antifungal properties. According to experts, this drug helps in the treatment of chlamydia, giardiasis and other infectious diseases.

Release form and composition

The drug Macmiror is available in the form of tablets for oral use, coated with a protective film coating in blisters of 10 pieces, packed in a cardboard box. The pack contains 2 blisters with tablets and detailed instructions with a description.

Each Macmiror tablet contains 0.2 g of the active ingredient – ​​Nifuratel, as well as a number of auxiliary components

They also produce vaginal cream and suppositories (Makmiror complex), which in addition to Nifuratel additionally contain.

Indications for use

What does Macmiror help with? Tablets are prescribed if the patient has:

• pyelonephritis, cystitis, etc., if the disease is caused by microorganisms sensitive to nitrofuran;
• vaginitis, vulvovaginitis;
• Giardia and amoebas in the intestines;
• diseases of the gastrointestinal tract caused by the bacterium Helicobacter pylori.

Instructions for use

Macmiror is prescribed in a daily dose determined by the doctor individually for each patient and depends on the diagnosis. According to the instructions, tablets are prescribed to patients according to the following scheme:

• For inflammatory diseases of the urinary tract and vaginal infections, 1 tablet of Macmiror is prescribed 3 times a day for 10 days.
• For sexually transmitted infections, treatment with the drug should be carried out together with a partner, after which it is necessary to undergo control tests.
• For diseases of the digestive canal caused by the bacterium Helicobacter pylori, 2 Macmiror tablets are prescribed 3 times a day. The course of treatment is at least 1 week; for children under 14 years of age, the dose of the drug is calculated individually, depending on body weight.
• For intestinal amebiasis and giardiasis, adult patients are prescribed 2 tablets 2 times a day for 10 days.

Vaginal cream

Prescribe 2.5 g of cream 1-2 times a day (morning or evening) for 8 days. The required dose of cream should be administered using a graduated applicator.

Instructions for use of the graduated applicator

Screw the graduated applicator onto the tube of cream. Take the required amount of cream (in accordance with the scale lines indicating the amount in grams) by pressing on the tube.

Disconnect from the tube, insert into the vagina, squeeze out the contents of the applicator, pressing on the rod. The presence of a special nozzle allows you to introduce the cream without damaging the hymen.

To do this, you need to remove the cannula from the top of the rod and screw it onto the head of the syringe from the opposite side before inserting the cream into the vagina.

Vaginal suppositories

1 vaginal suppository is administered daily in the evening before bed for 8 days or as recommended by your doctor. If necessary, treatment can be repeated after menstruation. To achieve the maximum therapeutic effect, the suppository should be inserted into the upper part of the vagina.

Suppositories are not used for treatment in children. For this category of patients, it is recommended to use vaginal cream complete with an applicator (graduated syringe).

Pharmacological action

Macmiror is an antimicrobial drug from the nitrofuran group; has antiprotozoal, antibacterial and antifungal effects. It has low toxicity and high efficiency, which determines a wide range of its clinical action.

Highly effective against Helicobacter pylori and Papiliobacter, gram-negative and gram-positive microorganisms. Range of action includes: Enterococcus faecium, Enterococcus faecalis, Staphylococcus aureus, Bacillus subtilis, Shigella flexneri 2a, Shigella flexneri 6, Escherichia coli, Shigella sonnei, Salmonella typhimurium, Salmonella typhi, Salmonella enteritidis, Klebsiella spp., Enterobacter spp., Serratia spp. , Morganella spp., Citrobacter spp., Rettgerella spp., Pragia fontium, Rahnella aquatilis, Budvicia aquatica and Acinetobacter spp., other atypical enterobacteria, as well as protozoa (Trichomonas, Giardia, amoeba); less active against Proteus vulgaris, Proteus mirabilis and Pseudomonas aeruginosa.

It is the drug of choice for the treatment of shigellosis, salmonellosis and other acute intestinal bacterial infections. Highly active against fungi of the genus Candida, active against Trichomonas vaginalis. Particularly effective against Helicobacter pylori strains resistant to metronidazole.

Contraindications

• fructose intolerance;
• high individual sensitivity to any component of the drug;
• isomaltose/sucrose deficiency;
• glucose-galactose malabsorption.

Side effects

Nausea, vomiting, allergic skin rashes.

During pregnancy and breastfeeding

The use of the drug during pregnancy is possible only under strict indications, if the expected benefit to the mother outweighs the potential risk to the fetus, because nifuratel penetrates the placental barrier. So it is better not to use this drug during pregnancy.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided, because nifuratel is excreted in breast milk. There are no contraindications to the use of Macmiror Complex suppositories during pregnancy and lactation (breastfeeding).

Special instructions

It is recommended to increase the daily dose of the drug to 4-6 tablets when treating vaginal infections if Macmiror tablets are used as monotherapy. While taking the drug, you should abstain from sexual intercourse.

Drug interactions

Almost no interaction. When taking Macmiror and nystatin simultaneously, the effectiveness of the latter increases.

Analogues

Macmiror's analogues have a similar effect:

1. Amoxicycline.
2. Livarol vaginal suppositories.
3. Vagilak.
4. Macropen.
5. Pimafucin.
6. Nystatin.

Vacation conditions and price

The average cost of Macmiror (200 mg tablets No. 20) in Moscow is 816 rubles. The drug can be purchased freely in pharmacies; a prescription from a doctor is not required.

It is recommended to keep the tablets away from children at room temperature not exceeding 25 degrees. The shelf life of the medicine is indicated on the packaging and is 5 years from the date of manufacture. After the expiration date, the tablets cannot be taken orally.

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Macmiror is a drug with antifungal, antimicrobial and antiprotozoal action; nitrofuran derivative.

Release form and composition

Macmiror is produced in the form of film-coated tablets: biconvex, round, white (10 pieces in blisters, two blisters in a cardboard package).

Composition per 1 tablet:

• active ingredient: nifuratel – 200 mg;
• auxiliary components: rice starch, talc, gelatin, corn starch, polyethylene glycol 6000, magnesium stearate, acacia gum;
• tablet shell: magnesium carbonate, wax, sucrose, titanium dioxide.

Pharmacological properties

Pharmacodynamics

Nifuratel is an antimicrobial agent from the nitrofuran group. It has antifungal, antiprotozoal and antibacterial activity. The high efficiency of nifuratel along with low toxicity determines a wide range of its applications.

The drug is active against gram-negative and gram-positive microorganisms (both aerobic and anaerobic), as well as Helicobacter pylori and Papiliobacter. The minimum inhibitory concentration of nifuratel is 12.5–25 μg/ml, and it destroys from 44.3 to 93.2% of cultures.

The spectrum of action of the drug Macmiror includes the following microorganisms: Acinetobacter spp., Bacillus subtilis, Budvicia aquatica, Citrobacter spp., Enterococcus faecalis, Escherichia coli, Enterobacter spp., Enterococcus faecium, Klebsiella spp., Morganella spp., Pragia fontium, Rettgerella spp., Rahnella aquatilis, Staphylococcus aureus, Salmonella Typhi, Salmonella enteritidis, Salmonella typhimurium, Shigella flexneri 6, Shigella flexneri 2a, Shigella sonnei, Serratia spp., as well as protozoa (giardia and amoeba). The drug is less active against Pseudomonas aeruginosa, Proteus vulgaris and Proteus mirabilis.

For shigellosis, salmonellosis and other intestinal bacterial infections, Macmiror is the drug of choice.

Nifuratel is also used to treat infections caused by Trichomonas vaginalis and Candida fungi.

The drug has been proven to be highly effective against Helicobacter pylori strains that exhibit resistance to metronidazole, as well as increased activity against the main marker of bacterial vaginosis – Atopobium vaginae.

Pharmacokinetics

After oral administration, nifuratel is quickly absorbed from the digestive tract. It crosses the placental barrier and the blood-brain barrier and is also secreted into breast milk.

Metabolism occurs in muscle tissue and liver. The drug is completely eliminated from the body (from 30 to 50% of nifuratel is excreted unchanged). Excretion is carried out by the kidneys, while Macmiror produces a strong antibacterial effect in the urinary tract.

Indications for use

• giardiasis (giardiasis);
• amoebic dysentery (intestinal amebiasis);
• urinary tract infections (including urethritis, pyelitis, pyelonephritis, cystitis);
• vulvovaginal infections, the causative agents of which are microorganisms sensitive to nifuratel (chlamydia, bacteria, trichomonas, fungi of the genus Candida);
• chronic inflammatory diseases of the upper digestive tract associated with the bacterium Helicobacter pylori.

Contraindications

According to the instructions, Macmiror is contraindicated in patients with fructose intolerance, sucrase/isomaltase deficiency, glucose-galactose malabsorption syndrome (since the tablets contain sucrose), as well as persons with hypersensitivity to its main or auxiliary ingredients.

Macmiror, instructions for use (method and dosage)

Macmiror tablets are taken orally.

• Giardiasis: adults – 2 tablets two or three times a day; children - 30 mg/kg body weight per day in two or three doses; the course of treatment is 7 days;
• amoebic dysentery: adults – 2 tablets two or three times a day; children - 30 mg/kg body weight per day in two or three doses; the course of treatment is 10 days;
• urinary tract infections: adults – 1-2 tablets three times a day (depending on the severity of the infection); children – 30–60 mg/kg body weight per day in two doses; the course of treatment ranges from 7 to 14 days (on the recommendation of a doctor, therapy can be extended or a second course prescribed);
• vulvovaginal infections: adults – 1 tablet three times a day for 7 days (both sexual partners are treated simultaneously); children – 10 mg/kg body weight per day in two doses for 10 days;
• diseases of the upper digestive tract associated with the bacterium Helicobacter pylori: adults – 2 tablets two or three times a day; children - 30 mg/kg body weight per day in two or three doses; the course of treatment is 7 days.

Side effects

Macmiror can cause adverse reactions from the gastrointestinal tract (bitterness in the mouth, nausea, heartburn, vomiting, diarrhea), as well as allergic reactions (itching, skin rash).

Overdose

To date, no cases of overdose of nifuratel have been reported.

Special instructions

If only Macmiror tablets are used orally to treat vaginal infections, it is recommended to increase the dose to 4-6 tablets per day. During the period of drug therapy, you should avoid sexual intercourse.

Impact on the ability to drive vehicles and complex mechanisms

Macmiror does not affect the ability of patients to operate complex and potentially dangerous mechanisms, as well as to engage in activities that require high concentration and rapid psychomotor reaction.

Use during pregnancy and lactation

Nifuratel crosses the placental barrier, so use of the drug during pregnancy is possible only under strict indications, when the expected benefit for the mother is higher than the potential risk to the fetus.

Drug interactions

Combined use with nystatin leads to an increase in its antifungal effect.

Analogues

Analogs of Macmiror are: Betadine, Vokadin, Hexicon, Iodoxide, Macmiror Complex, Osarbon, Furazolidine, Chlorhexidine, Ecovag, etc.

Terms and conditions of storage

Store in a dark place, out of reach of children, at a temperature of no more than 25 °C.

The shelf life of the tablets is 5 years.