Thiamine chloride. Thiamine (vitamin B1), injection solution (ampoules)

Thiamine chloride solution is a source of vit. B1, used to regulate metabolic processes.

Indications for use

The main indications for the use of such a drug as Thiamine chloride are hypovitaminosis conditions, as well as vitamin deficiency. IN 1. Used for complex therapeutic therapy for:

Intestinal atony
Radiculitis
Dystrophic changes in the myocardium
Neuritis and neuralgia
Thyrotoxicosis
Impaired absorption by the mucous membranes of the large and small intestines
Psoriasis and other skin diseases
Endarteritis
Impaired coronary circulation
Paralysis
Peripheral paresis
Intoxication.

Compound

One milliliter of solution for intramuscular administration contains 50 mg of the main component, which is thiamine chloride. Additionally, unithiol and purified water are present.

Medicinal properties

For many, it is difficult to immediately determine which vitamin is hidden under the name Thiamine chloride. This is vit. B1, it is water soluble. When it enters the body, it undergoes a phospholation process, during which it is converted into cocarboxylase, which is a coenzyme and takes part in many enzymatic reactions.

Vit. B1 is an active participant in metabolic processes and is necessary to ensure the conduction of nerve impulses at synapses.

Release form

Price from 25 to 49 rubles.

The solution is a slightly colored liquid with a pronounced aroma. Available in 1 ml ampoules, 10 amps are placed inside the package. The drug Thiamine chloride is not produced in tablets.

Thiamine chloride: instructions for use

The injection must be given intramuscularly. Injections of the drug should begin using minimal dosages (no more than 0.5 milliliters of a 5% solution); in the absence of adverse symptoms, the dose can be increased.

For adults, administration of 0.05 g of vit. B1, which corresponds to 1 milliliter of a 5% solution. You will need to give injections once a day every day. The course of therapeutic therapy is from 10 to 30 injections.

Use during pregnancy and pregnancy

This drug is prescribed for use according to the standard regimen.

Contraindications

The only contraindication to vitamin therapy is individual sensitivity to the synthetic analogue of vitamin B1.

Precautionary measures

Parenteral administration of a fortified drug is indicated only if it is not possible to take the drug orally. In the presence of Wernicke encephalopathy, the use of dextrose-based drugs should be carried out a little earlier than the use of thiamine.

Cross-drug interactions

You should not combine oral administration of other B-group drugs, since it is difficult to convert thiamine into active metabolites. It is worth considering that cyanocobalamin can enhance the analgesic effect of thiamine.

Before administration, you should not combine the synthetic analogue of Vit. B1 with steptomycin or penicillin (destruction of the main antibacterial components is observed), with nicotinic acid (thiamine is completely destroyed).

The drug significantly reduces the effectiveness of depolarizing muscle relaxants.

Side effects

During vitamin therapy the following may be observed:

Allergic manifestations (itching, urticaria-type rashes, Quincke's edema, excessive sweating, heart rhythm disturbances, quite rarely - anaphylactic shock)
Local painful sensations caused by low pH balance of solutions.

Overdose

There is an increase in side symptoms. When taking increased dosages, it is possible that signs of hyperthyroidism may occur (tremor, severe headaches, excessive agitation, changes in heart rate, sleep disturbance).

Symptomatic therapy is indicated.

Storage conditions and shelf life

Ampoules must be stored in their original packaging in a dark place at a temperature not exceeding 25 C. The fortified solution can be used for 3 years from the date of production.

Analogs

Microgen, Russia

Price from 36 to 364 rub.

Cocarboxylase exhibits a coenzyme effect, as it is a coenzyme of thiamine. Prescribed for the treatment of cardiovascular diseases, alcoholism, renal and respiratory failure. Produced in the form of a lyophilisate to make a solution.

Pros:

Low price
Wide spectrum of action
Prescribed for children.

Minuses:

A prescription is required to purchase.
Should not be combined with other B vitamins
During use, atony may develop.

Lekhim thiamine chloride

Another name for vitamin B1 is thiamine (thiamine pyrophosphate).

The function of vitamin B1 is to supply the body's cells with the necessary energy.

Before use, read the instructions.

Hypovitaminosis, vitamin deficiency. Lack of vitamin B1 in the body;
Periods when the vitamin is particularly lacking are lactation, as well as pregnancy;
Anorexia or underweight;
Intestinal diseases associated with food rejection;
Other diseases of the gastrointestinal tract;
Nausea, vomiting;
Psychological disorders: stress, overwork, neurasthenia, anxiety, irritability and others;
Skin sores caused by a disorder of the nervous system;
Other skin lesions, such as: eczema, psoriasis, dermatitis, lichen;
Metabolic disease;
Intoxication;
Liver dysfunction;
Heart disease, including heart failure;
Myocardial dystrophy;
Gastritis;
Delay in physiological development;
Gait disturbances;

Directions for use and doses

Thiamine injections can be given intramuscularly, intravenously, or subcutaneously. Please note: the injection of vitamin B1 should be administered slowly or by drip.

Daily value of thiamine

Adult representatives of the stronger sex require 1.2 – 2.1 mg of vitamin;
Elderly males – 1.2 – 1.4 mg;
Female representatives need 1.1 - 1.5 mg of thiamine, but pregnant mothers need 0.4 mg more, and nursing mothers need 0.6 mg more;
For children, the dose is administered regardless of age - 0.3 - 1.5 mg.

Intramuscularly (deep into the muscle), intravenously (slowly), not so often - subcutaneously. Adults take 20–50 mg of the drug (1 ml of 2.5–5% substance) once a day, every day, and can be gradually administered orally. Minors are prescribed 12.5 mg of thiamine (0.5 ml of 2.5% substance) every other day.

Orally, after meals, for adults for prevention purposes - 5-10 milligrams per day, for treatment purposes - 10 milligrams per dose 1-5 times a day, the dosage should not exceed 50 milligrams per day. Treatment lasts 30-40 days.

Use for children under three years of age – 5 milligrams every other day; from three to eight years – 5 milligrams, 3 doses per day, also every other day. Needs to be used for 20 – 30 days.

The course of treatment with vitamin B1 is 10–30 injections, regardless of age category.

Overdose

If the dose of thiamine is excessively exceeded, the following manifestations may occur: sleep disturbance, increased heart rate, agitation, headache, and some side effects of taking the drug may also increase.

In case of an overdose of thiamine, you should stop taking the vitamin and treat the symptoms caused by the solution.

Contraindications

This drug is practically harmless; it does not accumulate in the body, but is quickly excreted in the urine. That is why vitamin B1 has no special contraindications except for:

Thiamine intolerance;
Hypersensitivity;
Menopause in women.

Side effects:

Painful sensation at the injection site;
Allergic reactions such as hives, rash, itching;
State of shock (very rare);
Feeling your heart beat;
Tachycardia;
Restless state;
Visual impairment;
Chills;
Weakness of the whole organism;
Changes in liver function;
Deterioration of breathing, shortness of breath;
Difficulty swallowing;
Nausea.

Compatibility with other substances

According to the instructions, Thiamine should never be combined with the use of solutions containing sulfites, otherwise it will not bring any benefit (it will simply disintegrate).

If you administer an injection of vitamin B1 with other vitamins, then there is a high probability that the vitamin will not be completely absorbed by the body.

Drinking alcohol reduces the rate of exposure to thiamine after ingestion.

If the drug is administered intramuscularly and solutions containing sodium hydrosulfite, which acts as an antioxidant or preservative, are used, then thiamine will have an unstable effect.

The interaction of thiamine with carbonates, citrates, barbiturates with Cu2+ is prohibited, since the vitamin loses its stability in alkaline and neutral solutions.

The use of an injection of thiamine with pyridoxine or cyanocobalamin at the same time of parenteral administration is not recommended: pyridoxine will slow down the breakdown of thiamine into a more suitable form for absorption into the body, and cyanocobalamin may increase the allergic effects of thiamine.

In one injection, do not mix benzylpenicillin or streptomycin with vitamin B1 (antibiotics will be disrupted), as well as nicotine and thiamine (thiamine will be destroyed).

Release form

The cardboard box contains 10 glass ampoules with a label or text on the ampoule. Each ampoule has a volume of 1 milliliter.

Storage

The temperature should not exceed 30C. The storage place should be dry and dark. Be sure to hide it away from children's hands!

Store for three years from the date of manufacture. Once the expiration date has expired, this solution cannot be used!

When prescribing the vitamin thiamine chloride, many patients have a question: what kind of vitamin is thiamine chloride? In fact, this is the pharmaceutical name for vitamin B1 based on the active substance.

The main purpose of the drug is to replenish the lack of vitamin B1 in the body.

Thiamine is a water-soluble vitamin. This substance is involved in providing the body with carbohydrates, fats and proteins. With the participation of thiamine, the processes of conducting nervous excitation in synapses are carried out. The drug is excreted from the human body through the intestines, liver and kidneys.

Thiamine bromide is responsible for the formation of nerve excitation in synapses. It is necessary for the normal functioning of the digestive, nervous, cardiovascular and endocrine systems. It can be found in products of plant origin: nuts, liver, milk, egg yolks, carrots, yeast.

Thiamine bromide is available in various forms: tablets, dragees And ampoules for intramuscular and intravenous administration. For prophylactic purposes the drug can be prescribed to children from birth as prescribed by a doctor with the selection of the appropriate dosage. In case of intolerance to individual components of the medication, liquid or dry yeast from 50 to 100 grams per day may be prescribed as an alternative treatment.

Composition and release form

The drug is produced in ampoules in the form of a solution for intramuscular and intravenous administration. It appears as a clear, colorless or slightly colored liquid. The substance has a slight odor. Sold in ampoules of 1 or 2 ml, packed in a cardboard box of 10 pieces.

One 1 ml ampoule contains:

Thiamine hydrochloride 50 mg.
Excipients: water, unithiol, disodium edetate.

Indications for use

The drug is used for medical reasons as part of complex treatment:

Contraindications for use

Contraindications for use are:

Lactation period.
Pregnancy.
Childhood. It is a contraindication for certain dosage forms.
Intolerance to the components of the drug.

Thiamine hydrochloride: drug instructions

The medicine is produced in the form of capsules, tablets, powder and solution for injection. The substance can be purchased at the pharmacy in bags, bottles and ampoules of 1 ml, depending on the form of the medicine. The medicine is dispensed in the pharmacy strictly according to the prescription. You can buy it at the pharmacy under the trade names: “Thiamin chloride”, “Thiamin bromide”, “Thiamin hydrochloride”.

The solution is intended for intramuscular administration. To check the tolerability of the drug, the first dose is no more than 0.5 ml.

If the body tolerates the administered substance well, then with subsequent injections the dosage can be increased.

The duration of treatment and dosage are determined by the doctor after clinical studies. The recommended course of treatment does not exceed 30 days with a dosage of no more than 1 ml of solution. The use of the substance may be accompanied by side effects. Common side effects include:

Increased sweating.
Tachycardia.
The appearance of skin itching in the form of an allergic reaction.
Quincke's edema.
Hives.
Development of anaphylactic shock. Most often occurs with high intravenous dosage.

There may also be pain at the injection site for a long time. If you follow your doctor's recommendations and Thiamine Chloride's instructions for using injections, cases of overdose do not occur.

Intramuscular administration of the drug is prescribed in cases that exclude other possible routes of taking the drug. If the patient experiences vomiting and nausea, and has also undergone surgery on internal organs, he is prescribed medication in the form of injections. In other cases, you can limit yourself to taking thiamine tablets.

A high dosage of the drug may adversely affect certain tests, which must be taken into account when prescribing treatment. In patients with Wernicke encephalopathy, the drug should be used after prior administration of dextrose.

Interaction with other dosage forms

Simultaneous intramuscular administration of thiamine with various substances can lead to:

To the difficulty of the process of converting the vitamin into a biologically active form and to an increased risk of allergies when administered with vitamin B6.
To the development of allergic reactions when administered simultaneously with vitamin B12.
To reduce pharmacological activity when administered simultaneously with phentolamine, propranolol, and hypnotics.

It is prohibited to mix thiamine with benzylpenicillin, nicotinic acid, streptomycin and drugs containing sulfites in one syringe.

Thiamine chloride: instructions for use and reviews

Latin name: Thiamine chloride

ATX code: A11DA01

Active substance: thiamine

Manufacturer: JSC "Yerevan Chemical and Pharmaceutical Company" (Armenia), JSC "Moskhimfarmpreparaty named after. N. A. Semashko" (Russia), DALKHIMFARM (Russia)

Updating the description and photo: 22.10.2018

Thiamine chloride is a vitamin B1 preparation.

Release form and composition

Dosage form – solution for intramuscular (IM) administration: transparent liquid, slightly colored or colorless, with a characteristic faint odor (1 ml or 2 ml in an ampoule, 10 pcs in a cardboard box; 5 pcs in a blister pack , in a cardboard box 1 or 2 packages)

1 ml of solution contains:

active ingredient: thiamine hydrochloride – 50 mg;
auxiliary components: disodium edetate, unithiol (sodium dimercaptopropanesulfonate monohydrate), water for injection.

Pharmacological properties

Pharmacodynamics

Thiamine chloride is intended to compensate for the deficiency of vitamin B 1 in the body.

Vitamin B 1 (thiamine) dissolves in water and, during phosphorylation in the body, is converted into cocarboxylase, which participates in many enzymatic reactions as a coenzyme. Vitamin B 1 is necessary for the body to ensure normal metabolism of carbohydrates, proteins and fats, and the processes of conducting nervous excitation in synapses.

Pharmacokinetics

The level of thiamine concentration in the blood is relatively low; mainly free thiamine circulates in the plasma, and its phosphorus esters circulate in erythrocytes and leukocytes.

The process of phosphorylation of the vitamin occurs in the liver. The phosphorus ester thiamine diphosphate has coenzyme activity. Thiamine accumulation mainly occurs in the liver, brain, heart, kidneys, and spleen. The myocardium and striated muscles contain 50% of the total amount, and the internal organs contain 40%.

Excreted through the kidneys and intestines.

Indications for use

The use of Thiamine chloride is indicated for vitamin deficiency and hypovitaminosis B 1 and as part of complex therapy for the following diseases:

violation of coronary circulation;
myocardial dystrophy;
radiculitis, neuritis of various origins, neuralgia;
peripheral paresis, paralysis;
stomach and duodenal ulcers;
intestinal atony, anorexia, atonic constipation;
eczema, psoriasis, neurodermatitis, lichen planus and other dermatological pathologies associated with metabolic disorders and neurotrophic changes.

Contraindications

pregnancy period;
breast-feeding;
childhood;
hypersensitivity to the components of the drug.

Thiamine chloride should be prescribed with caution in Wernicke encephalopathy, in the premenopausal and menopausal periods.

Instructions for use of Thiamine chloride: method and dosage

The solution is used parenterally, by deep intramuscular injection.

The dose and period of treatment are prescribed by the doctor, taking into account clinical indications.

Side effects

With the use of Thiamine chloride, increased sweating, tachycardia, and the development of allergic reactions in the form of skin itching, urticaria, Quincke's edema, and anaphylactic shock are possible; at the injection site there is a feeling of pain.

Overdose

Overdose symptoms have not been established.

special instructions

It should be borne in mind that high doses of thiamine may distort the results of studies using the spectrophotometric method for determining the level of theophylline in blood serum or when using the Ehrlich reagent to determine the content of urobilinogen.

Anaphylactic reactions more often occur during intravenous administration of high doses.

According to the instructions, Thiamine chloride for Wernicke encephalopathy should be administered only after the use of dextrose.

Use during pregnancy and lactation

The use of thiamine hydrochloride is contraindicated during pregnancy and lactation.

Use in childhood

The drug solution should not be used to treat children.

Drug interactions

With simultaneous parenteral administration with Thiamine chloride:

pyridoxine (vitamin B 6): complicates the process of converting thiamine into a biologically active form, increases the risk of developing allergic reactions;
cyanocobalamin (vitamin B 12): enhances the allergenic effect of thiamine;
phentolamine, suxamethonium iodide, propranolol, hypnotics, sympatholytics (reserpine): reduce their pharmacological activity.

The drug should not be mixed in the same syringe with benzylpenicillin, streptomycin, nicotinic acid and solutions containing sulfites.

The drug is unstable in neutral and alkaline solutions.

Analogs

Analogues of Thiamine chloride are Vitamin B 1, Vitamin B, Aneurin, Aneuril, Benerva, Betabion, Benevrin, Berin, Betamin, Betaxin, Betiamin, Betanevrin, Bevital, Bevitin, Oryzanin, Christovibex, Vitaplex Bi, Neurovitan, Folic acid, Bepanten, Nicotinic acid

Terms and conditions of storage

Keep away from children.

Store at a temperature of 0–25 °C, protected from light.

Shelf life – 3 years.

The drug "Thiamin chloride" is vitamin B1, necessary for fat, protein, carbohydrate metabolism and the processes of nerve excitation in synapses. In the human body, this water-soluble vitamin is converted due to phosphorylation processes into cocarboxylase, which is a coenzyme of various enzymatic reactions. The drug "Thiamin chloride" is used in the treatment of vitamin deficiency, hypovitaminosis B1, polyneuritis, neuritis, peripheral paralysis, neurasthenia, neuralgia, radiculitis. In addition, it is used for the treatment of peptic ulcers, liver diseases, intestinal atony, endarteritis, myocardial dystrophy, and dermatoses of neurogenic origin. The drug "Thiamin chloride" is prescribed for skin itching, psoriasis, eczema, pyoderma.

Release form. Compound

The medicine is available in the form of an injection solution in ampoules in the amount of 10 pieces in one package. In terms of 100% substance, 1 ml of the product contains 50 mg of thiamine chloride. The auxiliary ingredients are water and unithiol.

Mode of application

The instructions for the drug “Thiamin Chloride” indicate that it should be administered intramuscularly; intravenous administration is also allowed. Adults are prescribed a dosage of 5% solution per day - 1 ml, children - 0.25 ml. Initially, it is recommended to administer parenterally in small doses; only if the drug is well tolerated, increase the dosage. The therapeutic course involves 10 to 30 injections. For intramuscular injections, the drug should be injected deep into the muscle (the injection can be quite painful), and for intravenous injections, the drug should be injected very slowly.

Side effects

Urticaria, skin itching, Quincke's edema, and anaphylactic shock may occur. Such negative phenomena can occur when the patient is prone to allergies, in premenopausal and menopausal women, and in patients suffering from alcoholism.

Contraindications

You should avoid using the drug “Thiamin Chloride” if you have hypersensitivity to the components included in the composition, allergic pathologies, hypertension, or idiosyncrasy. The drug is prescribed with increased caution for duodenal ulcers that have a hyperacid form and high excitability of the nervous system.

Use during pregnancy, lactation

No negative effects were identified during the use of the drug by pregnant and lactating women, therefore therapy with Thiamine Chloride is allowed for this category of patients.

Overdose

When using the drug in excess doses, side effects may increase. If you use the drug in large doses for a long time, there is a possibility of symptoms of hyperthyroidism: tremor, insomnia, headache, increased heart rate.

Interaction with other drugs

Do not mix the product with solutions containing sulfites, because the substance thiamine chloride disintegrates in them, as well as with penicillin (the antibiotic is destroyed) and nicotinic acid (thiamine is destroyed).