Characteristics and beneficial properties of vitamin B6 (pyridoxine) - is it possible to reduce the effect of contraceptive drugs? Pyridoxine: what is this vitamin, biological role, signs of deficiency and indications for use of pyridoxine hydrochloride.

Pyridoxine hydrochloride (pyridoxine)

Composition and release form of the drug

50 pcs. - polymer containers (1) - cardboard packs.
10 pcs. - contour cell packaging (5) - cardboard packs.
10 pcs. - contour cellular packaging (1) - cardboard packs.
10 pcs. - contour cell packaging (2) - cardboard packs.
10 pcs. - contour cell packaging (3) - cardboard packs.
10 pcs. - contour cell packaging (4) - cardboard packs.
10 pcs. - contour cell packaging (10) - cardboard packs.
10 pcs. - polymer containers (1) - cardboard packs.
20 pcs. - polymer containers (1) - cardboard packs.
30 pcs. - polymer containers (1) - cardboard packs.
40 pcs. - polymer containers (1) - cardboard packs.
100 pcs. - polymer containers (1) - cardboard packs.
50 pcs. - contour cellular packaging (1) - cardboard packs.
50 pcs. - contour cell packaging (2) - cardboard packs.
50 pcs. - contour cell packaging (3) - cardboard packs.
50 pcs. - contour cell packaging (4) - cardboard packs.
50 pcs. - contour cell packaging (5) - cardboard packs.
50 pcs. - contour cell packaging (10) - cardboard packs.

Pharmacological action

When used simultaneously, it potentiates the effect of diuretics.

When used simultaneously with levodopa, the effects of levodopa are reduced or completely inhibited.

When used simultaneously with isonicotin hydrazide, penicillamine, cycloserine, the effectiveness of pyridoxine may be reduced.

When used simultaneously with phenytoin, a decrease in plasma concentrations of phenytoin and phenobarbital is possible.

Special instructions

Use with caution for gastric and duodenal ulcers and coronary artery disease.

Pregnancy and lactation

For liver dysfunction

In case of severe liver damage, pyridoxine in high doses can cause deterioration of liver function.

1438 readers

The material is for informational purposes only. For accurate information, consult a specialist.

Pyridoxine (Pyridoxinum) is a substance involved in all cellular processes. The enzyme is produced in the intestinal microflora and can enter the body from the outside, as it is found in many products of animal and plant origin. In this section we will look in detail at what pyridoxine is, what vitamin it is and what its main functions are.

Pyridoxine: what vitamin is it?

Pyridoxine is known as vitamin B6. Its chemical formula is C8H11NO3. This water-soluble, odorless substance is presented in the form of colorless crystals with a sourish-bitter taste.

The vitamin is able to dissolve in alcohol and water, but is resistant to esters and fatty compounds. It does not react to heat or exposure to oxygen, but is quickly destroyed by light.

There are many synthetic analogues of this substance, the most popular of which is pyridoxine hydrochloride. It is available in tablets and ampoules for injection.

Daily requirement

The daily amount of vitamin B6 required for the normal functioning of the body depends on the gender and age of the patient. Detailed information is given in the tables.

Children

Men

Women

There are a number of cases when a person needs an increased dose of vitamin B6.

This occurs under the following conditions:

stress and depression;
increased physical activity;
prolonged exposure to the cold;
smoking and alcohol abuse;
the presence of hepatitis, radiation sickness, intestinal infections and HIV;
period of pregnancy and breastfeeding;
taking oral contraceptives.

In these cases, the dosage is calculated individually by the attending physician.

Biological role for the body

Pyridoxine is necessary for the normal functioning of the following processes in the body:

metabolism;
lipid and carbohydrate metabolism;
production and transformation of amino acids;
stabilization of the nervous system;
normalization of glucose and hemoglobin levels in the blood;
cell regeneration.

Just a note. Pyridoxine is an excellent vitamin for hair. It is often added to cosmetic masks and medicinal products. This substance helps strengthen hair follicles, stimulates hair growth and fights hair loss, and also prevents dandruff.

Signs of vitamin deficiency

There are a number of common symptoms that indicate vitamin B6 deficiency.

These include the following manifestations:

sleep disorders;
increased excitability or slowness of reactions;
apathy and depression;
causeless anxiety;
convulsive attacks and numbness of the limbs;
decreased body resistance;
hair loss;
muscle weakness;
frequent conjunctivitis;
nausea;
decreased appetite;
increased gas formation in the intestines;
inflammation of the mucous membranes in the mouth;
dry skin and other dermatological problems.

In children, hypovitaminosis due to a lack of vitamin B6 is manifested by the following symptoms:

frequent convulsions reminiscent of an epileptic attack;
excitability and tearfulness;
disruptions in digestion;
diathesis and allergic reactions;
slow growth and developmental delays.

Attention! Since the listed symptoms can accompany a number of other diseases, if such problems arise, you should undergo a comprehensive examination.

Indications for use of pyridoxine hydrochloride

Since pyridoxine is involved in almost all processes occurring in the human body, it is prescribed for disorders of various organs and systems.

Conditions where vitamin B6 supplementation is necessary include:

toxicosis during pregnancy;
premenstrual syndrome;
emotional disorders;
neurological problems;
diseases of the liver, heart and blood vessels;
dysfunction of the vestibular apparatus;
allergies;
dermatological problems;
dandruff, fragility and hair loss;
radiation sickness;
diabetes mellitus;
diseases of the musculoskeletal system;
other problems associated with excess body weight.

Attention! Pyridoxine in ampoules or tablets can only be used as prescribed by a doctor, and in the presence of ulcerative lesions of the stomach or intestines, therapy should be carried out under strict medical supervision.

Compatibility with other substances

When taking vitamin B6, it is important to consider how it combines with other microelements and medications.

Pyridoxine is necessary for the absorption of vitamin B12 and magnesium, for this reason their combined use is recommended. But if the substance is injected in combination with B12 and B1 in the same syringe, these vitamins neutralize each other's effects.

Medicines that can weaken the effect of vitamin B6 include medications from the following groups:

contraceptives;
barbiturates;
antibiotics;
narcotic substances;
antituberculosis, anticonvulsant, antiasthmatic, diuretic and antiepileptic drugs.

Pyridoxine reduces the effectiveness of drugs used for Parkinson's disease and enhances the effect of diuretics.

Where is vitamin B6 found?

Vitamin B6 can be obtained from food.

It is found in the following animal products:

chicken and pork liver;
sour cream;
sea fish (especially pink salmon and Atlantic herring);
beef;
egg yolks;
hard cheeses;
cottage cheese.

Products of plant origin that can compensate for the lack of pyridoxine include:

wheat flour;
sunflower seeds;
wheat bran;
garlic;
walnuts, hazelnuts and peanuts;
corn, barley and millet;
buckwheat;
peas;
potatoes;
porcini mushrooms;
zucchini;
grape;
apricots;
apples.

When planning your meals, you should be aware that vitamin B6 normalizes cellular processes and benefits the body only if used in moderation. Oversaturation is no less dangerous than deficiency.

Video on the topic

Pyridoxine: what vitamin is it, biological role, signs of deficiency and indications for use of pyridoxine hydrochloride

Pyridoxine is vitamin B6, which is involved in metabolic processes in the human body. This substance is not a medicine. Lack of vitamin in the body (hypovitaminosis) negatively affects the immune system and affects the functions of internal organs.

Pyridoxine is vitamin B6, which is involved in metabolic processes in the human body.

International nonproprietary name

The international name of this drug is Pyridoxine.

ATX and registration number

Registration number of pyridoxine in the anatomical-therapeutic-chemical classification A11HA02.

Pharmacotherapeutic group

This product is a vitamin.

Pharmacological properties

Pharmacodynamics

Pyridoxine plays the following role in humans:

Ensures normal functioning of the nervous system and maintains optimal blood sugar levels. This substance, like riboflavin, improves brain function (elevates mood and improves memory). If there is insufficient intake of pyridoxine in the body, convulsions are possible.
Participates in amino acid metabolism. The vitamin is an active coenzyme and is involved in decarboxylation processes.
Normalizes fat metabolism.
Helps reduce blood cholesterol levels, which is important for atherosclerosis.
Normalizes liver function.
Participates in erythropoiesis (formation of red blood cells).
Promotes the formation of nucleic acids.
Eliminates muscle spasm.
Reduces the need for insulin in diabetic patients.
Has a diuretic effect.
Has a beneficial effect on the skin, increasing its ability to regenerate.

EKMed - Vitamin B6 (Pyridoxine)

Vitamin B6 pyridoxine

Benefits of Vitamin B6 (Pyridoxine)

Pharmacokinetics

Metabolism (conversion of the vitamin) occurs in the liver tissues. Pyridoxamine phosphate and pyridoxal phosphate are formed there. B6 is deposited in muscle tissue, liver and central nervous system (brain and spinal cord). A special feature of the drug is its ability to penetrate the hematoplacental barrier and enter breast milk. When taking the vitamin in tablet form, pyridoxine is excreted primarily by the kidneys. When administered intravenously, part of the substance is excreted in the bile.

Daily requirement

The vitamin intake rate depends on age and load. The norm is from 0.4 mg (for newborns) to 2.4 mg (for elderly people). The daily requirement of an adult is on average 1.5 mg. In pregnant women, the norm is slightly higher.

What is vitamin b6 for?

Help in the fight against excess weight

Pyridoxine tablets are often used for weight loss. It is effective for obesity. Vitamin B6 promotes the breakdown of fats and optimal energy expenditure. Improving carbohydrate metabolism plays a major role in the process of losing weight. For greater effect, it is recommended to combine vitamin intake with physical exercise.

When an appointment is absolutely necessary

The indication for the use of pyridoxine hydrochloride is a clinically pronounced deficiency of this vitamin in the body. This condition is characterized by the following symptoms:

inability to remember large amounts of information;
forgetfulness;
dyspepsia in the form of decreased appetite and nausea;
drowsiness;
damage to the extrapyramidal system;
irritability;
sleep disturbance;
dry skin;
excessive hair loss on the scalp;
presence of cracks in the corners of the mouth;
symptoms of damage to the oral mucosa;
eye damage such as conjunctivitis (manifested by lacrimation, redness and itching);
depressed mood;
decreased performance.

Other possible indications are psoriasis, toxicosis during pregnancy, neurodermatitis, eczema, sideroblastic form of anemia, allergic dermatitis, atherosclerotic vascular damage, diabetes mellitus, exudative diathesis, herpes zoster, low levels of leukocytes in the blood, motion sickness and pathology of the nervous system.

Where is it contained?

The following foods are rich in pyridoxine:

yeast;
milk;
pistachios;
hazelnut;
beans;
raisin;
walnuts;
tomato-based sauces;
cereals (barley, millet, pearl barley, semolina, rice, buckwheat);
egg yolks;
fish (halibut, tuna, mackerel);
fruits (bananas, tangerines, grapes, melon, lemons, pomegranates and oranges);
vegetables (cabbage, tomatoes, carrots, avocado, rutabaga, potatoes, sweet peppers);
meat (rabbit, beef, chicken, lamb);
sprouted grain;
offal (beef liver, pork kidneys, heart).

Vitamin B6 in foods

WHAT IS THE DANGEROUS OF VITAMIN B6 DEFICIENCY? WHAT PRODUCTS DO IT CONTAIN?

If there is a lack of these products in the diet or impaired absorption of pyridoxine, hypovitaminosis develops.

Composition and release form of pharmaceutical preparations

Preparations based on pyridoxine hydrochloride are available in the form of tablets, dragees and solution for injection. The most popular drugs are Combilipen, Milgamma, Trigamma, Pyridoxine-Vial, Pyridoxine Bufus, Vitagamma and Binavit. Most often, the tablets and solution contain several vitamins at once. The main component of the tablets is vitamin B6. They are packaged in a jar of 50 pieces. The solution for injection is packaged in ampoules of 1 ml, 10 pcs. in each package. The amount of active substance is 2.5 or 10 mg.

Contraindications for pyridoxine hydrochloride

Injections and tablets are not prescribed to hypersensitive people. Pyridoxine should be taken with caution in case of severe liver damage due to chronic hepatitis, duodenal and gastric ulcers, as well as coronary heart disease.

Directions for use and dosage

Preparations based on vitamin B6 are taken regardless of meals.

Pills

In case of acute shortage of pyridoxine, tablets should be taken 4 times a day, 80 mg.

Ampoules

For injection (intramuscular or subcutaneous) administration of the drug, the daily dosage is 50-100 mg.

Special instructions when using pyridoxine hydrochloride

The instructions for use of the drug contain special instructions that must be followed when taking the vitamin. In high doses, the drug can cause liver dysfunction. Complex products (Milgamma, Kombilipen, Vitagamma) containing pyridoxine hydrochloride, thiamine and cyanocobalamin should not be prescribed to patients under 18 years of age.

During pregnancy and lactation

During pregnancy, medications with pyridoxine, like folic acid tablets, are prescribed according to strict indications in the required dosage.

In childhood

Children's age is not a contraindication to taking pyridoxine. Most combination drugs can only be prescribed to adults.

In old age

The vitamin can be used in old age. In this case, no dose adjustment is required.

For liver dysfunction

For impaired renal function

The drug does not affect kidney function and can be used for renal pathology.

Side effects of pyridoxine hydrochloride

When treated with vitamin B6, the following undesirable reactions are possible:

increased secretion of hydrochloric acid (dangerous with hyperacid gastritis and ulcers);
allergic reactions in the form of urticaria, exanthema or itching;
abdominal pain (in people with diseases of the stomach and duodenum due to increased acidity).

Effect on driving

The drug improves the functioning of the nervous system, which has a beneficial effect on attention.

Driving is not dangerous while taking vitamin B6.

Overdose

Manifestations of pyridoxine overdose are:

liver dysfunction;
changes in blood counts;
neurological symptoms.

Hemodialysis is not required in this case. Overdose is extremely rare.

Drug interactions

The effect of pyridoxine is enhanced when taken simultaneously with thiamine and other B vitamins. The concentration of pyridoxine increases when it is combined with hormonal medications. The vitamin enhances the effect of diuretics and reduces the therapeutic effect of levodopa. The drug is not recommended for use simultaneously with anti-tuberculosis drugs (Cycloserine). When the vitamin is combined with phenobarbital and phenytoin, the concentration of the latter decreases.

Alcohol compatibility

Drinking alcohol while taking pyridoxine will not give the desired effect of taking the vitamin and will lead to a worsening of neurological symptoms.

Conditions for dispensing from pharmacies

Preparations based on pyridoxine are sold only with a prescription.

Price

The cost largely depends on the manufacturer and composition of the drug. Complex vitamin preparations can cost about 300 rubles (Milgamma). The average price of pyridoxine in pharmacies is 50-70 rubles.

Storage conditions

When storing the vitamin, the following conditions must be met:

the room should be cool;
the place should be dry and protected from light;
Access to the drug for children should be limited.

Best before date

Analogues

Analogs of the drug are Pyridoxine-Vial, Pyridoxine-Bufus and Pyridoxine-Solopharm. Vitamin B6 is a component of such drugs as Protiocomb, Protub-2 (used in the treatment of tuberculosis), Protub-Lome, Protub-5, Protubpira, Compligam B, Resonizat Plus, Lyzobakt, Lomecomb, Tubavit, Milgamma, Combilipen, Trigamma, MexiB6 and Cyclomycin Plus.

With a lack of vitamin B6 in the human body, fatty infiltration of the liver occurs, hypochromic anemia and many other pathologies develop. Its deficiency manifests itself in the form of epileptic seizures, various dermatitis, and bone marrow hypofunction. One of the forms of vitamin B6 is pyridoxine hydrochloride, a substance that is prescribed for the treatment of vitamin deficiency. The drug of the same name restores full metabolism, activating the activity of enzymes.

What is Pyridoxine hydrochloride

Long-term infections, poor nutrition, malabsorption syndrome and prolonged stress cause a lack of vitamin B6 in the body. Pyridoxine hydrochloride is a drug that acts to correct this deficiency. Pyridoxine was accidentally discovered in the 20s of the twentieth century. This is an easily soluble transparent substance that does not accumulate in the human body, and once ingested, it is completely eliminated within 5-8 hours.

Pyridoxine hydrochloride belongs to the group of active coenzymes. Externally, this substance looks like transparent crystals, soluble in ethanol and water, having a lot of useful properties. The resulting alcohol or aqueous solution mixes well with essential oils and fats. The substance does not oxidize in air, but is easily decomposed by light. Pyridoxine hydrochloride melts when heated without chemical destruction.

Compound

Pyridoxine hydrochloride is a drug that belongs to a group of drugs that affect tissue metabolism in the human body. The active component included in its composition is 2-Methyl-3-hydroxy-4,5-di-(hydroxymethyl) or pyridine hydrochloride. It is a fine-crystalline white powder with a sourish-bitter taste and no odor. Excipients of the drug include:

talc;
calcium stearate;
colloidal silicon dioxide;
microcrystalline cellulose;
Dextrose monohydrate (glucose).

Pharmacological action

Pyridoxine normalizes the functioning of the central and peripheral nervous system, participates in the metabolism of aminocarboxylic acids: glutamic, tryptophan, methionine and others. Vitamin B6 promotes normal lipid metabolism. The use of Pyridoxine will help launch the body's metabolic processes by converting the active substance into pyridoxal-6-phosphate. This compound is a coenzyme substance that activates enzymes necessary for the normal metabolism of amino acids and lipids.

Release form

Vitamin Pyridoxine is available in the form of tablets and solution for injection. The tablet form of the medicine has a white color, a round flat-cylindrical surface, on which there is a separating line on one side. Tablets of 50 pieces are packaged in glass bottles, which are placed in a cardboard box with instructions. Pyridoxine hydrochloride solution is packaged in ampoules for injections (injections) of 1 ml. They sell them 10 pieces in one cardboard package with instructions and an ampoule knife. The shelf life of the medicine is 3 years from the date of manufacture.

What is vitamin b6 for?

In the human body, pyridoxine (vitamin B6) performs many important functions. With its deficiency, the blood becomes viscous, which leads to the formation of blood clots, increasing the risk of stroke and heart attack. Also, pyridoxine deficiency weakens the immune system, after which bacterial and viral infections easily develop. Vitamin B6 promotes the production of antibodies that protect the body from pathogenic microorganisms. Functions performed by pyridoxine:

regulates cholesterol levels;
improves red blood cell synthesis;
if the water balance is disturbed, it has a diuretic effect (diuretic);
regulates the balance of potassium, glucose, magnesium, sodium;
contribute to the normal functioning of the adrenal glands and thyroid gland;
regulates stomach acidity;
stabilizes the level of progesterone, estrogen, testosterone (male and female sex hormones).

When an appointment is absolutely necessary

women 2 weeks before the start of menstruation, when the body produces large amounts of estrogen;
people taking steroids;
women taking hormonal contraceptives;
people with obesity, as their metabolism is slow;
patients using antidepressants;
heavy smokers;
those who abuse alcohol;
AIDS patients;
drug addicts;
those who regularly experience physical and mental stress.

Instructions for use

Doctors prescribe taking pyridoxine in tablets or in the form of a solution in cases of vitamin B6 deficiency (hypovitaminosis) or complete absence (avitaminosis). The drug is often prescribed in complex therapy for the following diseases:

neurodermatitis (exudative diathesis);
toxicosis in pregnant women;
chronic dermatitis;
hepatitis;
chorea;
microcytic and hypochromic anemia;
parkinsonism;
stomach or duodenal ulcer.

Pills

To prevent various diseases, adults are prescribed oral tablets at a dosage of 2-5 mg/day. The daily dose for a child is 2 mg. Therapeutic dosages for adults are higher - from 50 to 100 mg daily, which are divided into several doses. It is recommended to take the tablets after meals with a small amount of water. The course of treatment is prescribed by the doctor. According to the annotation, the average duration of treatment is from 1 to 2 months. If anti-tuberculosis therapy is carried out, then to prevent dysfunction of the nervous system, pyridoxine hydrochloride is prescribed at a dose of 5-10 mg/day.

Ampoules

The injection solution is also used for the treatment and prevention of vitamin B6 deficiency or hypovitaminosis. Additionally, water for injection is used. In pharmacies the drug is sold strictly according to prescription. The solution is administered intramuscularly, subcutaneously or intravenously. For adults and children, the daily dose is prescribed individually, depending on the severity of the condition. The daily requirement of a child is up to 20 mg. Adults are recommended 100 mg/day, but up to 600 mg/day can be prescribed (convulsive syndrome), for a course of up to 25 days.

Pyridoxine hydrochloride during pregnancy

Taking the drug while expecting and breastfeeding (lactation) is permitted for medical reasons. The daily dose for pregnant women is standard, but should not exceed 100 mg/day. Vitamins Pyridoxine are prescribed for psycho-emotional distress of a pregnant woman, severe toxicosis. The drug helps maintain the necessary tone of the uterus, improves the immunity of the expectant mother, preventing the development of a variety of fetal diseases.

Side effects

Pyridoxine hydrochloride should be used strictly at the indicated dose, otherwise side effects may occur. Against the background of an overdose, an allergic reaction may occur in the form of hives, itching, and redness of the skin. With rapid intravenous administration, convulsions and a feeling of squeezing of the limbs (glove or stocking symptom) sometimes occur. For severe liver diseases, it is recommended to halve the dose, since the risk of side effects to the drug increases.

Contraindications

The drug is generally very well tolerated, and there is only one absolute contraindication for use - hypersensitivity to the active substance. Pyridoxine should be taken with caution in case of cardiac ischemia, peptic ulcer or duodenal ulcer. To avoid problems with the gastrointestinal tract, you should not prescribe the dosage yourself or exceed the prescribed doses.

Drug interactions

When combined with pyridoxine hydrochloride and hormonal contraceptives, the concentration of vitamin B6 in the blood plasma may be exceeded. If you take the drug together with diuretics, their effect is potentiated. When taken with Levodopa, the effects of the latter are inhibited. The combined use of Pyridoxine and Cycloserine (Isonicotin hydrazide, Penicillamine) weakens the effectiveness of vitamin B6.

Analogues

Structural analogues that contain the active substance pyridoxine are the drugs Pyridoxine Bufus and Pyridoxine Vial. There are similar vitamins or vitamin-like drugs that are similar in pharmacological group:

Medobiotin. Ingredients: pyridoxine hydrochloride, calcium pantothenate, nicotinamide, alpha-tocopherol acetate, riboflavin biotin. Medicine is prescribed for psycho-emotional disorders, disorders of the digestive tract, diseases of the skin, nails, and hair.
Magwit. Ingredients: pyridoxine hydrochloride, magnesium citrate. Indicated for damage to the nervous system, muscle cramps, intestinal spasms and other manifestations of vitamin B6 deficiency.
Magnelis. Ingredients: pyridoxine hydrochloride and magnesium lactate. Prescribed for convulsions, stress, effective for psoriasis, necessary for normalizing intestinal motility.

Instructions for use

Attention! The information is provided for informational purposes only. This instruction should not be used as a guide to self-medication. The need for prescription, methods and doses of the drug are determined exclusively by the attending physician.

General characteristics

international and chemical names: pyridoxine, (5-hydroxy-6-methylpyridin-3,4-diyl)-dimethanol hydrochloride);

basic physical and chemical properties: transparent, colorless or slightly yellowish liquid;

compound: 1 ml of solution contains pyridoxine hydrochloride 50 mg;

excipients: water for injections.

Release form. Solution for injection.

Pharmacotherapeutic group

Simple drugs vitamins (Vitamins- organic substances formed in the body with the help of intestinal microflora or supplied with food, usually plant matter. Necessary for normal metabolism and vital functions). Pyridoxine hydrochloride. ATS code A11N A02.

Pharmacological properties

Pharmacodynamics. Water-soluble vitamin B6 preparation. Plays an important role in metabolism (Metabolism- a set of chemical reactions that result in the synthesis or breakdown of substances and the release of energy. In the process of metabolism, the body perceives substances from the environment (mainly food), which, undergoing profound changes, turn into substances of the organism itself, the constituent components of the body); necessary for the normal functioning of the central and peripheral nervous system (Peripheral nervous system- part of the nervous system, represented by nerve fibers and nerve ganglia lying outside the central nervous system). Pyridoxine in phosphorylated form is coenzyme (Coenzymes- small molecules of a non-protein nature that specifically combine with the corresponding proteins, called apoenzymes, and play the role of the active center or prosthetic group of the enzyme molecule) many enzymes (Enzymes- specific proteins that can significantly accelerate chemical reactions occurring in the body without being part of the final reaction products, i.e. are biological catalysts. Each type of enzyme catalyzes the transformation of certain substances (substrates), sometimes only a single substance in a single direction. Therefore, numerous biochemical reactions in cells are carried out by a huge number of different enzymes. Enzyme preparations are widely used in medicine), carrying out the processes of decarboxylation and transamination amino acids (Amino acids- a class of organic compounds that have the properties of both acids and bases. Participate in metabolism in the body. About 20 essential amino acids serve as the links from which all proteins are built). Actively participates in metabolism (Metabolism- the totality of all types of transformations of substances and energy in the body, ensuring its development, vital activity and self-reproduction, as well as its connection with the environment and adaptation to changes in external conditions) tryptophan, methionine, cysteine, glutamic and other amino acids, metabolism histamine (Histamine- a derivative of the amino acid histidine. Contained in an inactive, bound form in various organs and tissues, it is released in significant quantities during allergic reactions, shock, and burns. Causes dilation of blood vessels, contraction of smooth muscles, increased secretion of hydrochloric acid in the stomach, etc.), fat metabolism, normalizes lipid metabolism during atherosclerosis (Atherosclerosis- a systemic disease characterized by damage to the arteries with the formation of lipid (mainly cholesterol) deposits in the inner lining of the vessels, which leads to a narrowing of the lumen of the vessel up to complete blockage), increases diuresis (Diuresis- the amount of urine excreted over a certain time. In humans, daily diuresis averages 1200-1600 ml), potentiates the effect of diuretics.

Pharmacokinetics. Metabolized in the liver to form pharmacologically active metabolites (Active metabolites- drug metabolites with biological (pharmacological) activity. Active metabolites may have biological activity similar to the drug)- pyridoxal phosphate and pyridoxaminophosphate. Distributed predominantly in muscles, liver and CNS (CNS- the main part of the nervous system, represented by the spinal cord and brain. Functionally, the peripheral and central nervous systems represent a single whole. The most complex and specialized part of the central nervous system is the cerebral hemispheres). Penetrates through placenta (Placenta- an organ that carries out communication and metabolism between the mother’s body and the fetus during intrauterine development. It also performs hormonal and protective functions. After the birth of the fetus, the placenta, along with the membranes and umbilical cord, is released from the uterus) and into breast milk. Excreted by the kidneys (when administered intravenously with bile (Bile- a secretion produced by glandular cells of the liver. Contains water, bile salts, pigments, cholesterol, enzymes. Promotes the breakdown and absorption of fats, enhances peristalsis. The human liver secretes up to 2 liters of bile per day. Preparations of bile and bile acids are used as choleretic agents (allochol, decholin, etc.)) about 2% is excreted).

Indications for use

Hypo- and avitaminosis B6, toxicosis of pregnancy, atherosclerosis, anemia (Anemia- a group of diseases characterized by a decrease in red blood cells or hemoglobin in the blood)(including sideroblastic), leukopenia (Leukopenia- the content of leukocytes in the peripheral blood is less than 4000 in 1 μl, due to the influence of various damaging factors on the body) of various origins, diseases nervous system (Nervous system- a set of formations: receptors, nerves, ganglia, brain. Performs the perception of stimuli acting on the body, conducts and processes the resulting excitation, and forms adaptive responses. Regulates and coordinates all functions of the body in its interaction with the external environment)(radiculitis, neuritis, neuralgia, parkinsonism (Parkinsonism– a neurological syndrome caused by a malfunction of the metabolism of adrenaline, norepinephrine, dopamine and their ratio in the subcortical nerve nodes (ganglia). Characterized by rhythmic muscle tremor (fingers, sometimes lips and other parts of the body tremble), rigidity, decreased volume and speed of movements, hypokinesia), Little's disease), involutional depression (Depression- mental disorder: melancholy, depressed mood with pessimism, monotony of ideas, decreased motivation, retardation of movements, various somatic disorders), sharp and chronic hepatitis (Chronic hepatitis– damage to hepatocytes caused by various reasons, characterized by hepatocellular necrosis and inflammation, lasting more than 6 months), seborrheic and non-seborrheic dermatitis (Dermatitis– an inflammatory reaction that occurs as a result of direct exposure to external factors on the skin), shingles (Shingles(Herpes zoster) - herpetic skin lesions, which are characterized by a group arrangement of small blisters on an erythematous or edematous base), neurodermatitis, psoriasis (Psoriasis- a chronic hereditary skin disease with diverse clinical manifestations. The most common is ordinary psoriasis - profusely scaly papules and plaques on the scalp, elbows, forearms, hands, legs, feet, lower back, and buttocks. Complaints of itching. In this disease, keratinocytes are formed 28 times more than normal), exudative diathesis, air and seasickness (Seasickness– a painful condition that develops from motion sickness in the water. It manifests itself especially often and fully at sea), Meniere's disease (Meniere's disease– a symptom complex resulting from a violation of auditory and vestibular functions); to reduce toxic (Toxic- poisonous, harmful to the body) effects of anti-tuberculosis drugs.

Directions for use and doses

Administered intramuscularly, intravenously or subcutaneously, especially if due to intestinal malabsorption (Malabsorption in the intestines– disruption of the active process of penetration of nutrients and microelements through intestinal enterocytes into the internal environment of the body) taking the drug orally is not possible.
Parenterally (Parenteral- dosage forms administered, bypassing the gastrointestinal tract, by applying to the skin and mucous membranes of the body\; by injection into the vascular bed (artery, vein), under the skin or muscle\; by inhalation, inhalation (see Enteral)) for all of the indicated routes of administration, the daily dose for adults is 0.05-0.1 g. For children, the dose is prescribed by the doctor individually and another vitamin B6 preparation with a lower dosage is used.
The course of treatment is 30 days.
For parkinsonism, 2 ml of a 5% solution per day is administered intramuscularly. The course of treatment is 20-25 days, after 2-3 months a repeat course is carried out. According to another treatment regimen for this disease, a 5% solution is administered intramuscularly, at an initial daily dose of 50-100 mg, and then the daily dose is increased by 50 mg and brought to 300-400 mg per day, once. Therapy (Therapy- 1. The field of medicine that studies internal diseases is one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate the type of treatment (oxygen therapy\; hemotherapy - treatment with blood products)) in this case, it is carried out in courses of 12-15 days.
To treat involutional depression, the drug is administered intramuscularly at a dose of 200 mg per day.
When treating sideroblastic anemia, the drug is administered intramuscularly, 0.1 g, 2 times a week (at the same time it is recommended to take folic acid, riboflavin (Riboflavin- water-soluble vitamin. Contained in dairy and meat products, salad vegetables, chicken yolk, brewer's yeast. Lack of this vitamin in the body leads to skin lesions, blurred vision, gastritis, colitis), vitamin B12).

Side effect

Possible allergic reactions (skin rash, hives (Hives- a disease characterized by the formation of limited or widespread itchy blisters on the skin and mucous membranes)). Individual cases have also been described anaphylactic shock (Anaphylactic shock- a symptom complex of acutely occurring general severe manifestations of immediate-type allergic reactions, mainly characterized by initial excitation and subsequent depression of the function of the central nervous system, bronchospasm, severe arterial hypotension) already after 1-2 injections (Injection- injection, subcutaneous, intramuscular, intravenous, etc. introduction into the tissues (vessels) of the body of small quantities of solutions (mainly medicines)) pyridoxine.

Contraindications

Hypersensitivity to the drug.

Overdose

Symptoms of overdose: increased side effects (allergic reactions: skin rash, urticaria, anaphylactic shock).

Treatment: drug withdrawal, symptomatic therapy.

Features of application

In case of severe liver damage, pyridoxine in large doses can cause deterioration of liver function.
Use with caution for gastric ulcers and duodenum (Duodenum- the initial section of the small intestine (from the gastric outlet to the jejunum). The length of the human duodenum is equal to the diameter of 12 fingers (hence the name)), coronary heart disease.

Interaction with other drugs

Do not prescribe simultaneously with levodopa, because pyridoxine weakens the effect of the latter. Do not mix in the same syringe with solutions of vitamins B1 and B12. Hormonal contraceptives, hydralazine, penicillamine increase the need for pyridoxine. The drug reduces the neurotoxic effect of isoniazid and also eliminates the side effects of tricyclics antidepressants (Antidepressants- products that improve mood, relieve anxiety and tension, and increase mental activity. Used to treat depression), apressin, cyclosporine, lowers the level of phenobarbital, diphenine in the blood.
Effective with long-term use of chloramphenicol to prevent ophthalmological complications. Pyridoxine increases diuresis and enhances the effect diuretics (Diuretics- medicinal substances that increase the excretion of urine by the kidneys and thereby promote the removal of excess water and sodium chloride from the body).
In patients with chronic (Chronic- a long, continuous, protracted process, occurring either constantly or with periodic improvements in the condition) heart failure, the drug potentiates the effect of cardiac glycosides.

General Product Information

Conditions and shelf life. Store in a place protected from light and out of reach of children, at a temperature not exceeding 25 °C.
Shelf life - 3 years.

Vacation conditions. According to the recipe.

Package. Solution for injection 5%, 1 ml in ampoules No. 10.

Manufacturer.LLC "Pharmaceutical company "Zdorovye".

Location. 61013, Ukraine, Kharkov, st. Shevchenko, 22.

Website. www.zt.com.ua

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- "Darnitsa"

This material is presented in free form on the basis of the official instructions for medical use of the drug.