Zinc sulfate dia ophthalmic. Compositions of solutions and mode of deposition of pyrophosphate electrolytes
Zinc is a trace element that is involved in metabolism and stabilization of cell membranes.
Active substance of the drug:
ZINC SULFATE / ZINC SULFATE
Pharmacological action of Zinc sulfate / zinc sulfate
Zinc is a trace element that is involved in metabolism and stabilization of cell membranes. It is part of the main enzymes and participates in various biochemical reactions. Affects regeneration processes and transmission of nerve impulses. Strengthens the effect of insulin, promotes the synthesis of cortisol.
When taken orally, it stimulates skin regeneration processes and hair growth, has an immunomodulatory effect and, in high doses, an emetic effect. Effective in the treatment of acne and alopecia. Zinc coagulates proteins to form albuminates.
Antimicrobial activity is a consequence of coagulation of microorganism proteins. In microquantities, it is resorbed and substrate stimulates a number of enzyme systems (including alkaline phosphatase, ACE, alcohol dehydrogenase, superoxide dismutase, carbonic anhydrase).
Zinc sulfate, when applied topically, has an antiseptic, astringent, drying and local anti-inflammatory effect.
Pharmacokinetics of the drug.
Indications for use:
For oral administration: zinc deficiency in the body with disturbances of anabolic and immunological processes (prevention and treatment); as part of complex therapy - hypogonadism, acrodermatitis enteropathica, alopecia areata, cerebral palsy, liver disease, diabetes mellitus, diffuse connective tissue diseases, long-term GCS therapy (especially at the time of drug withdrawal).
For external and local use: to accelerate the healing of superficial wounds and ulcers, inflammatory processes of the skin and mucous membranes.
Dosage and method of administration of the drug.
Individual, depending on the indications, the patient’s age and the dosage form used.
Side effects of Zinc sulfate / zinc sulfate:
Possible: allergic reactions.
Contraindications to the drug:
Hypersensitivity to zinc sulfate.
Special instructions for the use of Zinc sulfate / zinc sulfate.
With long-term use of zinc preparations, the likelihood of a deficiency of copper ions in the body should be taken into account.
During systemic use, you should avoid consuming dairy products, because at the same time, the absorption of zinc salts from the gastrointestinal tract slows down; avoid drinking alcoholic beverages.
Interaction of Zinc sulfate / zinc sulfate with other drugs.
Zinc sulfate reduces the absorption of tetracyclines and copper ions. Thiazide diuretics increase the excretion of zinc in the urine. Folic acid may interfere with the absorption of zinc to a small extent. Iron supplements in high doses, complexing agents (including penicillamine) significantly reduce the absorption of zinc.
Pharmaceutically incompatible with silver salts, lead, quinine, ichthyol, citral (forms poorly soluble compounds), with alkali-reacting substances (forms zinc oxide hydrate), with protargol (subject to coagulation).
Zinc sulfate eye drops are used to treat diseases of the mucous membrane of the eyeball caused by microorganisms and to prevent inflammation in the presence of a foreign body in the eye. They have antiseptic, anti-inflammatory and astringent effects.
Composition, release form
The main active ingredient of these eye drops is zinc sulfate. They are available in the form of 0.1%, 0.25% and 0.5% solution, which is placed in a 5 ml dropper tube. When dissolved, the medicine is transparent and colorless.
Pharmacological action
Zinc sulfate is an antiseptic that is obtained by evaporating sulfuric acid and zinc. In order to obtain the required concentration of the drug, during its production they resort to a hydrolysis reaction.
Zinc sulfate coagulates protein compounds to form complexes (albuminates). This explains the drying, antiseptic and astringent effect of this drug. The folding of protein molecules of microorganisms, which occurs as a result of the coagulation reaction, causes their death. When Zinc sulfate eye drops are used topically in ophthalmology, systemic effects are minimized. To enhance the effect of the drug, it is often used together with boric acid.
Indications for use
Indications for the use of Zinc sulfate eye drops include microbial etiology.
Directions for use and doses
Eye drops Zinc sulfate is instilled into the conjunctival sac, 1-2 drops of solution 2 times a day. The course of treatment in most cases is 7 days, but the doctor can change its duration if necessary.
Before the first procedure, remove the cap and cut the protective membrane. After instillation of the drug, the tube must be tightly closed. It is not recommended to touch the end of the dropper to the conjunctiva of the eyeball and the skin around them.
Contraindications
Zinc sulfate eye drops are not prescribed to patients who have a history of hypersensitivity to zinc salts, or who use contact optics. If there is a need to use them while wearing them, it is recommended to correct your vision with glasses during treatment with the drug.
Side effects
Some patients experienced mild allergic reactions that disappeared after discontinuation of the drug.
Overdose
An overdose of Zinc sulfate eye drops is usually not observed if the dosage and duration of treatment are observed. If these requirements are not met, dryness and irritation of the conjunctiva of the eye may develop.
When ingesting liquid, drug poisoning occurs. It is manifested by vomiting, nausea and fever. If signs of a systemic effect of the drug appear, it is necessary to rinse the stomach, take sorbents and symptomatic (antiemetic and antipyretic) drugs.
Interaction with other tools
Zinc sulfate cannot be combined with other ophthalmic drugs used topically, except boric acid.
Storage conditions and special instructions
Zinc salt of sulfuric acid has found its use in medicine due to its ability to have a drying, antiseptic, and astringent effect. When applied topically, zinc sulfate causes the death of microorganisms at the site of application.
Depending on the specifics of the pathological process, zinc sulfate can be used either alone or in combination with other medicinal substances, for example, boric acid; This combination of active substances is contained in boron-zinc drops.
- conjunctiva;
- corneas;
Show all
General information
The active ingredient of this medicine is zinc sulfate. It was its ability to form albuminates (complexes with protein molecules) that determined the possibility of using this substance in medicine.
| Pharmacological group | Ophthalmic products |
| Pharmacological action | The drug belongs to the category of antiseptics |
| Concentration of active substance (zinc sulfate) | The pharmaceutical industry produces dosages of 0.1; 0.25; 0.5% |
| Dosage form | Eye drops, which are a colorless liquid that does not contain sediment or other foreign matter. |
| Release form | Dropper tube with a capacity of 5 milliliters |
| Mechanism of antiseptic action | Zinc sulfate has the ability to cause coagulation of protein molecules that are vital for pathogenic microorganisms. As a result, bacteria die |
| Compatibility with other drugs | Zinc eye drops are incompatible with other medications except sulfuric acid solution. Zinc sulfate can be used simultaneously with it, for example, in the form of a combination of zinc-boron drops |
| Storage conditions | The drug should be stored at a temperature of no more than 25 degrees out of the reach of children. |
| Shelf life of sealed packaging | 3 years |
| Shelf life of an opened bottle | No more than two weeks |
| Conditions for dispensing from pharmacies | The product is allowed to be purchased without a prescription |
This product is manufactured by a domestic manufacturer; its cost in pharmacies ranges from 45 to 60 rubles.
In what cases are zinc eye drops used?
Indications for use are infectious and inflammatory lesions of the structures of the anterior part of the eyeball of bacterial origin:
Redness of the eyes or the patient's suspicion of an inflammatory process are not reasons for using drops. This medicine should be used as prescribed by a doctor.
Contraindications and adverse reactions
A contraindication to the use of zinc sulfate is hypersensitivity to this substance.
You should not use zinc drops when wearing contact lenses. During therapy, contact lenses should be replaced with glasses.
When using zinc eye drops, allergic manifestations may occur. This situation requires stopping the use of drops and contacting a specialist to adjust the therapy.
In case of intolerance to zinc drops, replacing this product with any of its analogues with the same composition (Amuzol, Zincteral) is not advisable.
Zinkit, Zincteral.
Composition and release form
Zinc sulfate.
film-coated tablets (44 mg, corresponding to an elemental zinc content of 10 mg; 124 mg, corresponding to an elemental zinc content of 45 mg);
eye drops (0.1 -0.5% solution);
solution for topical use (0.25-0.5%).
Pharmacological action
A trace element for systemic use, it participates in the biochemical reactions of the body, in the process of hematopoiesis, and in the activity of the endocrine glands.
Large amounts of zinc are found in the skin (primarily in the epidermis), hair, muscles, liver tissue and bone tissue. Increases resistance to infectious diseases, promotes wound healing, accelerates growth, increases performance, improves memory, and prevents hair loss.
When applied topically, it has an astringent, drying, irritating, antiseptic, and immunomodulatory effect. Zinc ions coagulate proteins to form albuminates. The antimicrobial activity of zinc is a consequence of the coagulation of microbial proteins. Stimulates the activity of alkaline phosphatase enzymes, alcohol dehydrogenase, superoxide dismutase, carbonic anhydrase, etc.
Indications
Enteropathic acrodermatitis. Alopecia alopecia, malignant alopecia. Pustular and phlegmonous acne.
It is possible to use the drug in complex therapy for generalized itching and difficult-to-heal ulcers, as well as during the period of discontinuation of GCS after their long-term use. Hypogonadism, cerebral palsy, liver disease, diabetes.
Locally - conjunctivitis, laryngitis, urethritis, vaginitis.
Application
To replenish the body's physiological need for zinc - 10-15 mg orally, for therapeutic purposes - 20-50 mg 2 times a day.
Enteropathic acrodermatitis: children over 3 years of age and adults - no 1 tablet 3 times a day before meals; as the symptoms disappear, the dose is reduced to 1 tablet 2 times a day, then 1 tablet a day until complete recovery.
Malignant alopecia: children under 7 years old - 1 tablet 3 times a day before meals.
If necessary, the dose can be increased: children under 7 years old - 4-5 tablets/day, adults - up to 6 tablets/day.
You should avoid consuming dairy products, as this inhibits the absorption of zinc salts from the gastrointestinal tract. Avoid drinking alcoholic beverages. Emetic - 100 mg once.
Zinc sulfate coagulates proteins and forms albuminates. Zinc sulfate, depending on the depth of penetration, causes the development of drying, astringent and irritating effects; the irritating effect causes vomiting (due to reflex stimulation of the vomiting center and irritation of the corresponding areas of the gastric mucosa). The antimicrobial activity of zinc sulfate is possible due to the coagulation of microorganism proteins. Zinc sulfate in microquantities is absorbed and has a substrate-stimulating effect on a number of enzyme systems - ACE, alkaline phosphatase, alcohol dehydrogenase, carbonic anhydrase, superoxide dismutase and others.
Indications
For local use: conjunctivitis, vaginitis, urethritis, laryngitis; for oral administration: the need to induce vomiting, zinc deficiency in the body with disturbances of immunological, anabolic and other processes (therapy and prevention); as part of complex treatment: hypogonadism, cerebral palsy, alopecia areata, liver disease, diffuse connective tissue diseases, diabetes mellitus.
Method of application of zinc sulfate and dose
Locally: conjunctivitis - eye drops 0.1–0.5%, laryngitis - spraying or lubrication with a 0.25–0.5% solution, urethritis and vaginitis - douching with a 0.1–0.5% solution. Orally (during or after meals): prevention of hypozincemia - 10-15 mg per day (physiological need of the body for zinc), therapy - 2-3 times a day 20-50 mg; as an emetic - 100–300 mg once.
When using zinc sulfate, it is necessary to take into account the possibility of developing a deficiency of copper ions in the body. During systemic use, it is necessary to avoid eating dairy products, as this slows down the absorption of zinc salts in the gastrointestinal tract, and also avoid drinking alcoholic beverages.
Contraindications for use
Hypersensitivity.
Restrictions on use
No data available.
Use during pregnancy and breastfeeding
No data available.
Side effects of zinc sulfate
Nausea, diarrhea, vomiting, allergic reactions.
Interaction of zinc sulfate with other substances
Zinc sulfate reduces the absorption of copper ions and tetracyclines. The excretion of zinc in the urine is enhanced by thiazide diuretics. To a small extent, folic acid may interfere with the absorption of zinc. Complexing drugs (including penicillamine) and high doses of iron supplements significantly reduce the absorption of zinc. Zinc sulfate is pharmaceutically incompatible with lead and silver salts, quinine, citral, ichthyol, alkali-reactive substances, and protargol.
Overdose
In case of an overdose of zinc sulfate, fever, dehydration, pulmonary dysfunction, imbalance in plasma electrolytes, lethargy, renal failure, and muscle movement disorders develop. Supportive and symptomatic treatment is necessary.
