Augmentin instructions for use for children tablets. Special antibiotic for children - Augmentin suspension

The article provides an overview of the drug Augmentin (a children's antibiotic, release form - powder for preparing a suspension) in dosages of 200 mg/28.5 mg/5 ml and 400 mg/57 mg/5 ml, and provides an example of calculating the dose of the drug depending on the weight of the child.

Augmenitin suspension is a broad-spectrum antibiotic. It can be given from the first months of life.

Augmentin is an antibiotic that contains two active ingredients. First - amoxicillin, which has an antibacterial effect(but its effect is inhibited by certain types of microorganisms). To eliminate this drawback, the drug was introduced second active substance - Clavulanic acid. It destroys the defense of microorganisms, which in its absence are not susceptible to the action of Amoxicillin.

Indications for use

Side effects

After taking Augmentitis in children, it often begins due to death. To normalize stool, give your baby something from this list:

• (three times a day, 1 jar).
• (1 capsule three times a day). If the child does not know how to swallow capsules, their contents should be poured into a spoon and mixed with water.
• (together with taking an antibiotic, 15-60 drops, depending on age). When the stool returns to normal, the dosage is reduced by half, but they still drink it for 14 days.

Digestive disorders are a negative consequence after treatment with Augmentitis.

Sofia, the mother of 5-year-old Gleb, spoke in a review about how you can cope with possible nausea caused by taking Augmentin:

“For my son’s sore throat, the doctor prescribed Augmentin in suspension. But after the first dose, Gleb began to feel sick and eventually vomited. And the son suffers, and there is no benefit. The next day we went to the clinic again to change the drug. The doctor was surprised by the request and asked to give reasons for it. After listening to the complaints, he said that nausea can be dealt with if you take the antibiotic strictly before meals. That is, they sat down at the table, drank the suspension - and immediately eat. After this recommendation, my son no longer felt sick, and the sore throat quickly went away.”

Analogues of the drug

If the pharmacy does not have Augmentin, then you can buy analogues instead. Let's give a brief overview of them:

1. - a Slovak drug that differs only in the list of excipients.
2. Flemoklav- a Dutch analogue, characterized by improved absorption of active ingredients. Therefore, the effectiveness of treatment with Flemoklav is higher.
3. Panclave- medicine made in Europe.
4. Rapiklav, Ranklav, Klamosar- cheap analogues can be purchased from Russian and Indian manufacturers. They are distinguished by reduced bioavailability, but an affordable price.

I'll be healthy!

Augmentin is a widely used antibiotic that is effective but sometimes causes diarrhea. Side effects can be eliminated by following the rules for taking the drug and combining it with bacterial therapy. And you don’t have to go to another pharmacy for Augmentin if you find any of the analogues. In terms of the composition of the active ingredients, they are identical, only the manufacturers differ.

Alisa Nikitina

Many diseases in children cannot be cured without resorting to antibiotics. Very often doctors prescribe these powerful medications. A competent parent should know how, when and why the baby should take an antibacterial drug. And to make it easier for you to understand, we have prepared for all occasions.

Self-medication can be harmful to your health.

Augmentin tablets: instructions for use

Compound

5 ml of suspension contains

Active ingredients: amoxicillin (in the form of amoxicillin trihydrate) 400 mg;

Clavulanic acid (as potassium clavulanate) 57 mg,

Excipients: xanthan gum, aspartame, colloidal anhydrous silicon dioxide, magnesium stearate, crospovidone, croscarmellose sodium, sodium benzoate, strawberry flavor, anhydrous silicon dioxide.

Description

White or almost white powder with yellowish particles, with a characteristic odor. The prepared suspension is white or almost white. When standing, a white or almost white precipitate slowly forms.

Pharmacological action

Augmentin® is a combination antibiotic containing amoxicillin and clavulanic acid, with a broad spectrum of bactericidal action, resistant to beta-lactamase.

Amoxicillin is a semisynthetic broad-spectrum antibiotic that is active against many gram-positive and gram-negative microorganisms. Amoxicillin is destroyed by beta-lactamases and has no effect on microorganisms that produce this enzyme. Its mechanism of action is to inhibit the biosynthesis of cell wall mucopeptides.

Clavulanic acid is a beta-lactamate, structurally related to penicillins, which has the ability to inactivate a wide range of beta-lactamases. Beta-lactamases are produced by many gram-positive and game-negative bacteria. The action of beta-lactamases can lead to the destruction of some antibacterial drugs even before they begin to act on pathogens. Clavulanic acid blocks the action of enzymes, restoring the sensitivity of bacteria to amoxicillin. In particular, it is highly active against plasmid beta-lactamases, which are often associated with drug resistance, but is less effective against chromosomal type 1 beta-lactamases.

The presence of clavulanic acid in Augmentin® protects amoxicillin from the destructive action of beta-lactamases and expands its spectrum of antibacterial activity to include microorganisms that are usually resistant to other penicillins and cephalosporins.

Augmentin® has a bactericidal effect on the following microorganisms:

Gram-positive aerobes: Bacillis anthracis*, species of the genus Corynebacterium, Enterococcus faecalis*, Enterococcus faecium* Listeria monocytogenes, Nocardia asteroides, Staphylococcus aureus*, Coagulase-negative staphylococci* (including Staphylococcus epidermidis*), Streptococcus agalactiae, Streptococcus pneumoniae, eptococcus pyogenes, species of the genus Streptococcus, Streptococcusviridans ;

Gram-positive anaerobes: species of the genus Clostridium, species of the genus Peptococcus, species of the genus Peptostreptococcus;

Gram-negative aerobes: Bordetella pertussis, species of the genus Brucella, Escherichia coli*, Gardnerella vaginalis, Haemophilus influenzae*, Helicobacterpylori, species of the genus Klebsiella*, species of the genus Legionella, Moraxella catarrhalis*(Branhamella catarrhalis), Neisseria gonorrhoeae*, Neisseria meningitidis*, Pasteurellamultocida, Proteus mirabilis*, Proteus vulgaris*, Salmonella species*, Shigella species*, Vibrio cholerae, Yersinia enterocolitica*;

Gram-negative anaerobes: Species of the genus Bacteroides* (including Bacteroides fragilis), Species of the genus Fusobacterium*;

Other: Borrelia burgdorferi, Chlamydiae, Leptospira icterohaemorrhagiae, Treponema pallidum;

*Some strains of these bacterial species produce beta-lactamases, which makes them insensitive to amoxicillin monotherapy.

Pharmacokinetics

Suction

Both active ingredients of Augmentin®, amoxicillin and clavulanate, are highly soluble in aqueous solutions with a physiological pH value and are quickly and completely absorbed from the gastrointestinal tract after oral administration. Absorption of the active ingredients of Augmentin® is optimal when taken at the beginning of a meal.

Distribution

Therapeutic concentrations of amoxicillin and clavulanic acid are created in various organs and tissues, interstitial fluid (lungs, abdominal organs, adipose, bone and muscle tissues, pleural, synovial and peritoneal fluids, skin, bile, urine, purulent discharge, sputum). The binding of amoxicillin and clavulanic acid to plasma proteins is low and amounts to 25% of the total amount of clavulanic acid and 18% of amoxicillin, about 70% remains free in the blood serum. Amoxicillin passes into breast milk. Trace amounts of clavulanic acid are also detected in breast milk. With the exception of the risk of sensitization, no other negative effects on the health of breastfed infants are known. Amoxicillin and clavulanic acid penetrate the placental barrier.

Eliminations

Amoxicillin is excreted primarily by the kidneys, while clavulanic acid is eliminated through both renal and extrarenal mechanisms.

Metabolism

Amoxicillin is partially excreted into the urine as inactive penicillin acid in an amount equivalent to 10-25% of the initial dose. Clavulanic acid in the body undergoes intensive metabolism to 2,5-dihydro-4-(2-hydroxyethyl)-5-oxo-1H-pyrrole-3-carboxylic acid and 1-amino-4-hydroxy-butan-2-one and is released with urine and feces, as well as in the form of carbon dioxide through exhaled air.

Indications for use

- upper respiratory tract infections [(including ear, nose and throat infections), such as recurrent tonsillitis, sinusitis, otitis media, usually caused by Streptococcus pneumoniae, Haemophilus influenzae*, Moraxellacatarrhalis* and Streptococcus pyogenes]

Lower respiratory tract infections, such as exacerbations of chronic bronchitis, lobar pneumonia and bronchopneumonia, usually caused by Streptococcus pneumoniae, Haemophilus influenzae* and Moraxella catarrhalis*

Urogenital tract infections (cystitis, urethritis, pyelonephritis)

Gynecological infections usually caused by strains of the family Enterobacteriaceae* (mainly Escherichia coli*), Staphylococcus saprophyticus and strains of the genus Enterococcus, as well as gonorrhea caused by Neisseria gonorrhoeae*

Infections of the skin and soft tissues, usually caused by Staphylococcus aureus*, Streptococcus pyogenes and Bacteroides species*

Bone and joint infections (osteomyelitis caused by Staphylococcus aureus*)

Other mixed infections (septic abortion, sepsis, abdominal infections)

Contraindications

Hypersensitivity to beta-lactams, such as cpenicillins and cephalosporins

Jaundice or impaired liver function that developed during the use of Augmentin or beta-lactam antibiotics

Infectious mononucleosis

Directions for use and doses

The dosage regimen is set individually depending on age, body weight, kidney function, and the severity of the infection. Augmentin® is recommended to be taken at the beginning of a meal. Treatment should not be continued for more than 14 days without re-evaluating the patient's condition. If necessary, it is possible to carry out stepwise therapy (at the beginning, intravenous administration of the drug, followed by switching to oral administration).

Adults and children over 12 years of age or weighing more than 40 kg

Children under 12 years of age or weighing less than 40 kg

The dose, depending on age and weight, is indicated in mg/kg body weight per day, or in milliliters of suspension.

25/3.6 mg/kg/day in 2 divided doses for mild and moderate infections (upper and lower respiratory tract infections, skin and soft tissue infections).

45/6.4 mg/kg/day in 2 divided doses for the treatment of more serious infections (upper respiratory tract infections, such as otitis media and sinusitis, lower respiratory tract infections, such as bronchopneumonia and genitourinary tract infections).

Below are tables for selecting a single dose of Augmentin® depending on body weight.

For children over 2 years old

25/3.6 2-6 years (13-21 kg) 2.5 ml Augmentin® suspension

7-12 years (22-40 kg) 5.0 ml Augmentin® suspension

400mg/57mg 2 times a day

45/6.4 2-6 years (13-21 kg) 5.0 ml Augmentin® suspension

mg/kg/day 400 mg/57 mg 2 times a day

7-12 years (22-40 kg) 10.0 ml Augmentin® suspension

400mg/57mg 2 times a day

For children from 2 months to 2 years

There are insufficient data to indicate dosage for children less than 2 months of age.

The maximum daily dose is 80-90 mg/kg/day, divided into 2 doses.

Method of application of the suspension

The suspension is prepared immediately before the first use.

The powder should be dissolved with boiled water cooled to room temperature, gradually shaking and adding water to the mark on the bottle. Then let the solution stand for about 5 minutes to ensure complete dissolution. The bottle should be shaken well before each use. To accurately dose the drug, you should use a measuring cap, which should be rinsed well with water after each use.

Patients with impaired renal function

Dose adjustments are based on the maximum recommended dose of amoxicillin and creatinine clearance.

Patients with liver dysfunction

Treatment is carried out with caution; regularly monitor liver function.

Side effect

Often (≥1/100,

Candidiasis

Nausea, vomiting, diarrhea

Uncommon (≥1/1000,

Dizziness, headache

Dyspepsia

Moderate elevation of liver enzymes

Skin rash, itching, urticaria

Rarely (≥1/10000,

Reversible leukopenia (including neutropenia), thrombocytopenia

Erythema multiforme

Unknown

Reversible agranulocytosis and hemolytic anemia, increased bleeding time and prothrombin time index

Angioedema, anaphylaxis, serum sickness-like syndrome, allergic vasculitis

Reversible hyperactivity and seizures

Colitis pseudomembranous or hemorrhagic

Change in color of the surface layer of tooth enamel

Hepatitis, cholestatic jaundice

Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exanthematous pustulosis

Interstitial nephritis, crystalluria

Overdose

Symptoms: possible gastrointestinal disorders and water-electrolyte imbalance. Amoxicillin crystalluria has been described, in some cases leading to the development of renal failure.

Treatment: symptomatic therapy, correction of water and electrolyte balance. Augmentin® is removed from the blood using hemodialysis.

Interaction with other drugs

It is not recommended to use Augmentin® simultaneously with sprobenicide. Probenicide reduces the tubular secretion of amoxicillin, and therefore the simultaneous use of Augmentin® and probenecid may lead to an increase in the blood level of amoxicillin.

Concomitant use of allopurinol and Augmentin® may increase the risk of allergic reactions. There are currently no data on the simultaneous use of allopurinol and Augmentin®.

Augmentin® affects the intestinal flora and leads to a decrease in reabsorption and a decrease in the effectiveness of combined oral contraceptives.

Features of application

Before starting treatment with Augmentin®, it is necessary to collect a detailed history regarding previous hypersensitivity reactions to penicillins, cephalosporins or other allergens.

Serious and sometimes fatal hypersensitivity reactions (anaphylactic reactions) to penicillins have been described. If an allergic reaction occurs, treatment with Augmentin® should be discontinued and alternative therapy initiated. In case of severe hypersensitivity reactions, the patient should be given adrenaline immediately. Oxygen therapy, intravenous steroids, and airway management, including intubation, may also be required.

Augmentin® should not be prescribed if infectious mononucleosis is suspected, since in patients with this disease, mamoxicillin can cause a skin rash, which makes diagnosing the disease difficult.

Long-term treatment with Augmentin® may be accompanied by excessive growth of microorganisms that are insensitive to it.

In general, Augmentin® is well tolerated and has the low toxicity characteristic of all penicillins. When treating with Augmentin® for more than 7 days, it is recommended to evaluate the functions of the kidneys, liver, and hematopoiesis.

In patients receiving Augmentin®, an increase in prothrombin time is occasionally observed, therefore, when using Augmentin® and anticoagulants simultaneously, appropriate monitoring should be carried out.

Augmentin® should be used with caution in patients with impaired liver function.

In patients with impaired renal function, the dose of Augmentin® should be adjusted according to the degree of impairment.

In patients with reduced diuresis, crystalluria may occur in rare cases. During the administration of high doses of amoxicillin, it is recommended to take sufficient fluids and maintain adequate diuresis to reduce the likelihood of the formation of amoxicillin crystals. The presence of clavulanic acid in Augmentin® may cause nonspecific binding of IgG and albumin to the red blood cell membrane, which leads to a false gram-positive test.

Augmentin®, powder for suspension for oral administration 400 mg/57 mg/5 ml contains 3.32 mg/ml aspartame, a source of phenylalanine. The drug is not recommended for use in patients with phenylketonuria.

The drug contains maltodextin (glucose). It is not recommended to use the drug in patients with glucose-galactose malabsorption.

Pregnancy and lactation

Augmentin® can be used during breastfeeding. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

It is unknown, however, side effects of the drug should be taken into account.

Release form

Powder for the preparation of suspension for oral administration 400 mg/57 mg/5 ml, 35 ml.

The powder for preparing the suspension is placed in Type III transparent glass bottles with a screw-on metal cap equipped with a dispenser cap.

1 bottle, along with instructions for medical use in the state and Russian languages, is placed in a cardboard pack.

Storage conditions

Store in a dry place at a temperature not exceeding 25 °C. Store the prepared suspension in the refrigerator at a temperature of 2 °C to 8 °C and use within 7 days.

You should consult your doctor and read the instructions before use.

Augmentin ® is a combined antimicrobial drug that contains amoxicillin, which has a bactericidal effect, and clavulanic acid (clavulanate), which inhibits a group of bacterial enzymes - β - lactamase. The latter hydrolyze penicillin and cephalosporin antibiotics, as a result of which the latter do not have time to demonstrate their antimicrobial effect. Augmentin ® is a drug with an extended spectrum of activity.

Aerobes and anaerobes are sensitive to Augmentin ®. The antibiotic has a bacteriolytic effect, i.e. destroys pathogenic microorganisms. Amoxicillin itself degrades in the presence of β-lactamases, so it is ineffective in eradicating microbial cultures that synthesize these enzymes. Clavulanic acid, which is part of the drug, imparts stability to semisynthetic penicillin, thereby expanding the spectrum of its activity.

Clavulanic acid is similar in structure to penicillin antibiotics. Plasmid β-lactamases, which cause resistance (resistance) of pathogens, are susceptible to clavulanate. However, the inhibitor has no effect on type 1 bacterial enzymes. The manufacturing country of Augmentin ® is England.

Instructions for use of Augmentin ® 1000, 875, 125, 500 and 125 mg tablets

The tablets are not crushed or chewed, but are swallowed whole, and washed down with clean non-carbonated water (100 milliliters is enough). As for the suspension, the required amount of the finished solution is measured using a measuring cap or a syringe on which divisions are applied. The syringe or measuring cup is thoroughly washed after use.

Augmentin ® in liquid form (suspension) is preferably taken before meals, which significantly improves absorption. In addition, this will reduce the likelihood of unwanted reactions from the esophagus, stomach and intestines.

The suspension is used exclusively orally. 0.06 liters of boiled water at room temperature is poured into a container with powder. Close the bottle tightly with a lid and shake thoroughly until a homogeneous mass is obtained.

The powder will dissolve completely if left for a few minutes. Next, the procedure is repeated, adding water up to the mark on the bottle. The shelf life of the prepared solution is a week; it is stored in the general chamber of the refrigerator. The technology for preparing the suspension is described in detail in the insert included in the package.

All dosage forms are taken at the same intervals. For example, if a doctor has prescribed you to take an antibiotic twice a day, this means that Augmentin ® must enter the body every 12 hours.

The minimum course of treatment with Augmentin ® is five days. After diagnosis and in the absence of repeated examination, therapy should not last more than 14 days. If, upon review of the clinical situation, a slow but positive dynamics of the recovery process was revealed, then the course of treatment is continued. The duration of the course must be agreed with the attending physician.

Experts often resort to stepwise antibacterial therapy, which involves the 2-stage use of antibiotic drugs: for example, switching from parenteral to oral administration. In the case of Augmentin ®, the injection method is first practiced, and then the tablets are used.

Pharmacological group

Augmentin ® also belongs to the group of inhibitor-protected penicillins.

Pharmacological parameters

Augmentin ® causes the death of facultative flora and blocks the biosynthesis of the cell membrane, which performs structural, protective and transport functions. Amoxicillin, coupled with clavulanic acid, enhances the bactericidal activity of segmented neutrophils, which play a very important role in protecting the body from infections of bacterial and fungal etiology. Clavulanic acid stimulates the adhesion and motor response of neutrophils (leukocytes) to a chemical stimulus.

Pharmacology of amoxicillin

Amoxicillin is destroyed by penicillinase. The antibiotic is resistant to acidic environments. Its target is the bacterial enzyme glycopeptide transpeptidase. The antimicrobial agent suppresses the synthesis of murein, which performs the antigenic and mechanical functions of osmotic cell protection.

Pharmacology of clavulanic acid

Clavulanate has its own antimicrobial activity. Pseudomonas aeruginosa and Enterococcus are sensitive to the inhibitor (minimal activity); Haemophilus influenzae and Enterobacteriaceae (moderate activity); Bacteroides, Moraxella, Staphylococcus, Streptococcus, Neisseria gonorrhoeae, Chlamydia trachomatis and Legionella (high activity). Like other β-lactam antibiotics, clavulanic acid interacts with penicillin-binding proteins of gram+ and gram-pathogens and promotes the dissolution of the cell membrane.

Pharmacokinetic parameters

Pharmacokinetic data were obtained in experimental and laboratory studies in volunteers after administration on an empty stomach.

Speed ​​of achieving effective drug concentration in plasma

The drug is rapidly and completely absorbed from the gastrointestinal tract. The absorption of the active ingredients of Augmentin ® is optimal if taken before meals. The time to reach maximum concentration is 3/4 hours.

Distribution of lek. means in the body

Therapeutic concentrations of amoxicillin and clavulanate are formed in the organs of the chest and abdominal cavity, adipose tissue, bones, muscles, bile, serous-purulent discharge and fluids: pleural, produced by the pleura, synovial, filling the joints, peritoneal, responsible for moisturizing the abdominal wall, and tissue contained in the pericellular spaces. The degree of binding to plasma proteins is low (no more than thirty percent for both substances).

Metabolism and Elimination

The antibiotic is eliminated by the kidneys (glomerular filtration and tubular secretion). After a single oral dose, both substances are eliminated from the body within six hours. The half-life depends on the dose, the average is one hour.

Composition of Augmentin ®

The main components of the antibiotic are Amoxicillin (amoxicillin) and Clavulanic acid (clavulanic acid), the physiological effects of which are associated with the therapeutic properties of Augmentin ®. Contains xanthan gum (stabilizer, whitish powder, odorless and tasteless), L-Aspartyl-L-phenylalanine (sweetener), butanedioic acid (colorless crystals, soluble in water and ethanol) and food flavors (berry and citrus flavors) .

Augmentin ® recipe in Latin

Rp: Augmentini 0.875.

D.t. d. N. 20 in tab.

S. 1 tablet 2 times a day

Augmentin ® release form

The pharmaceutical industry produces Augmentin ® in the form of:

1. White powder having a specific smell. When water is added, a suspension of a similar color is formed. After settling in the container, a sediment gradually forms.
2. Tablet form, containing 250 milligrams of Amoxycillinum and 125 milligrams of clavulanic acid. The tablets are film-coated, with the name “Augmentin ®” engraved on the surface in Latin.
3. Tablet form, containing 500 milligrams of Amoxycillinum and 125 milligrams of clavulanic acid. On one side of the table. The letters "AC" are printed.
4. Tablet form, containing 875 milligrams of Amoxycillinum and 125 milligrams of clavulanic acid. The letters "A" and "C" are die-cut on the top and bottom sides. The pharmaceutical corporation Glaxosmithklein ® does not supply Augmentin ® syrup for children to the pharmaceutical market.

Photo of the packaging of Augmentin ® tablets 875 mg/125 mg

What does Augmentin ® help with?

Augmentin ® is active against pathogens susceptible to it. The combination medicine is prescribed for infections caused by microorganisms that are resistant to the antibiotic included in the composition.

Taking Augmentin ® promotes eradication of the following microbial cultures:

• gram+ aerobes, requiring free molecular oxygen for energy synthesis processes (including strains synthesizing β-lactamases): Staphylococcus aureus, S. epidermal, streptococci, pneumococcus, fecal enterococcus, corynebacteria, listeria;
• gram aerobes: Escherichia coli, Proteus mirabilis;
• gram+ anaerobes, receiving energy in the absence of oxygen: clostridia, peptostreptococci, peptococci, Proteus, Klebsiella, Salmonella, Shigella, Bordet-Gengou bacterium, Yersinia enterocolitica, Campylobacter jeuni
• etc. gram+ pathogens: bacteroides, including bacteroides fragilis.

Indications for use of Augmentin ®

The combination of amoxicillin with clavulanate is indicated for the treatment of diseases of bacterial origin in the following localizations:

• ENT organs: tonsillitis, sinusitis, otitis media (including relapses). The causative agents are streptococcus pyogenes, pneumococcus, and influenza bacillus.
• lower parts of the respiratory system: exacerbation of bronchitis, occurring in a chronic form, pyothorax, abscess, bronchogenic and lobar pneumonia, developing when the body is invaded by pneumococci and influenza bacillus.
• urinary system and genital organs: cystitis, pelvioperitonitis, endometritis, urethritis, pyelonephritis and diseases of the female reproductive system: vaginitis, salpingoophoritis, inflammatory adnextumor (enterobacteria, E. coli, saprophytic staphylococcus, enterococci, gonococcus causing gonorrhea).
• dermis and soft tissues, which include muscles, tendons, synovial membranes, adipose tissue, fibrous connective tissue: inflammation of the subcutaneous tissue, purulent inflammation of the tissues, furunculosis, panniculitis (staphylococcus aureus, st. pyogenic, bacteroides).
• bone tissue: purulent-necrotic processes developing in the bone and bone marrow (staphylococcus aureus). Augmentin ® is prescribed if long-term treatment is necessary.
• oral cavity: periodontal inflammation,
  maxillary sinusitis, severe dentoalveolar abscesses.

Indications for use include septic abortion, obstetric and intra-abdominal sepsis, septicemia, peritonitis, cholecystitis.

Who is Augmentin ® contraindicated for?

The antibiotic is not prescribed to patients with a history of hypersensitivity to amoxicillin, clavulanate, β-lactams and other components. The reasons for refusing therapy with this drug are:

• phenylketonuria is a hereditary disease caused by a metabolic disorder of α-amino-β-phenylpropionic acid;
• kidney pathologies and other severe dysfunctions, for example, low creatinine;
• infancy up to three months (for suspension);
• age up to twelve years and weight less than forty kilograms (for solid forms);
• lymphoblastosis is benign, since the antibiotic can provoke the appearance of rashes, which will complicate the diagnosis;
• previous episodes of Gospel disease.

Dosage of Augmentin ® for adults

Establishing a dosage regimen is the responsibility of the attending physician. When selecting a dosage, the doctor takes into account age, weight, the presence of diseases of the urinary system, the clinical condition of the patient, and individual characteristics.

Adults and children in puberty (adolescents from twelve years of age or with a body weight exceeding forty kg) should be prescribed eleven milliliters of a suspension at a dosage of 400 mg plus 57 mg, which is equivalent to one tablet containing 875 mg of amoxicillin.

Low doses of Augmentin ® are indicated for getting rid of skin infections and for recurrent inflammation of the tonsils. High doses are indispensable in the treatment of otitis, sinusitis, infections of bone and joint tissue.

For infants up to three months, due to the incompletely formed excretory function of the kidneys, the recommended dose is thirty milligrams per kg of body weight. As for premature infants, there is no reliable data on the dosage regimen.

Patients over sixty years of age do not require dosage adjustment. You should adhere to the recommendations that guide the treatment of young patients.

For persons with liver dysfunction, antibiotic therapy is prescribed with caution, while liver function testing is carried out on a regular basis.

For persons with renal failure, the dosage regimen is adjusted based on an assessment of creatinine clearance, which is the main quantitative indicator of the secretory organ.

Dosage of Augmentin ® for children in suspension 200 and 400 ml

In pediatric practice, Augmentin ® is prescribed to children in the form of a suspension.

Baby's age	Body weight (in kilograms)	Suspension dosage for children 125(in milliliters). Take three times per knock	Suspension 200 and 400. Take twice daily
From three months to twelve	Two-five	One and a half - two and a half	One and a half to two and a half ml suspension two hundred milligrams
	Six to nine	Five	Five ml suspension two hundred milligrams
12 months – five years	Ten to eighteen	Ten	Five ml suspension four hundred milligrams
Six - nine years	Nineteen to twenty eight	Fifteen or one table each. (250/120) three times a day	Seven and a half milliliters of four hundred milligram suspension or one tablet each. (500/120) three times a day
Ten - twelve years	Twenty nine - thirty nine	Twenty or one table each. (250/120) three times a day	Ten milliliters of four hundred milligram suspension or one tablet each. (500/120) three times a day

How to correctly calculate the dosage of Augmentin ® suspension for children (200 mg, 400 mg)

Parents cannot always correctly determine the dosage regimen. For clarity, we give an example of calculating the dosage for a girl whose therapist diagnosed inflammation of the bronchial mucosa. The child is one and a half years old and weighs ten kg.

Bronchitis leads to disruption of the normal functioning of a vital organ; if the disease occurs without respiratory failure, then the patient’s condition is classified as moderate-severe.

For moderate bronchitis, we take into account forty milligrams per kg. The girl weighs ten kg, so the single dosage is: forty * ten = four hundred milligrams. 400 mg of amoxicillin is contained in ten milliliters of a suspension of 200 mg plus 28.5 mg/5 ml or in 5 ml of 400 mg plus 57 mg/5 ml.

Augmentin ® during pregnancy and breastfeeding

During tests on animals carried out in the laboratory, it was revealed that both components penetrate the utero-placental barrier and are determined in minimal quantities in mother’s milk. However, antibiotic therapy with Augmentin ® is not a teratogenic factor, because The drug does not disrupt the embryonic development of the fetus. Augmentin ® is used both orally and parenterally during pregnancy.

In isolated cases of women with a violation of the integrity of the membranes of the fetal bladder before the onset of labor, it was found that preventive therapy with this medication may be associated with inflammation of the small and large intestines (necrotizing enterocolitis) in the newborn. Augmentin ® should be taken only for vital indications.

Treatment with the antibiotic Augmentin ® has only a minor effect on breastfeeding (BF), with the exception of the risk of sensitization.

A woman carrying a child should take into account that almost all antibiotics are poorly tolerated by the body. This pharmacological group has many contraindications and adverse reactions. For example, during treatment, patients often experience candidiasis.

Antibiotic drugs are strong allergens that during pregnancy can trigger skin rashes, asthmatic attacks and even anaphylactic reactions that threaten the life and health of the mother. In addition, Augmentin ® inhibits the enzymatic activity of the flora of the digestive tract, which leads to dysbacteriosis. A pregnant woman may experience constipation, diarrhea, abdominal pain and increased gas production.

Penicillin affects the bone marrow, which causes disruption of hematopoiesis. Aplastic anemia tops the list of serious complications.
Taking Augmentin ® during pregnancy is possible, but only if the therapeutic effect for the expectant mother outweighs the potential risk to the fetus. In the first trimester, it is advisable to find alternative methods of treatment or select the safest antibiotics possible.

Side effects and effects when taking Augmentin ®

Adverse drug reactions are listed by frequency of occurrence:

• candidiasis caused by yeast-like fungi of the genus Candida. Taking antibiotics leads to an increase in the population of this yeast. Yeast-like fungi Candida are part of the normal microflora of the oral cavity, vagina and colon;
• leukopenia, in which patients experience general weakness, rapid pulse, and low-grade fever;
• thrombocytopenia, accompanied by increased bleeding, problems stopping bleeding, frequent nosebleeds;
• agranulocytosis, the clinical picture of which manifests itself in the form of damage to the body by infections due to a decrease in the effectiveness of the immune response;
• high physical activity and excitability of a person;
• stool disorders (frequent bowel movements);
• nausea that occurs when taking high doses;
• antibiotic-associated colitis;
• disease black villous tongue, characterized by hyperplasia of the filiform papillae of the tongue and their keratinization;
• darkening of tooth enamel. Teeth will not change color if proper oral care is taken;
• drug-induced hepatitis, because almost all antibiotics have hepatotoxicity;
• increased bilirubin, which is signaled by increased fatigue, yellowness of the skin and mucous membranes;
• high concentration of alkaline phosphatase. Patients complain of loss of appetite and pain in the right hypochondrium;
• intrahepatic cholestasis, accompanied by a lack of access of bile to the intestine and impaired permeability of bile capillaries;
• skin rashes diagnosed in patients with individual intolerance and concomitant diseases;
• a symptomatic form of polymorphic erythema of toxic-allergic origin. In the first stages, clearly defined edematous papules of a pinkish tint appear;

Side effects from the liver are more common in males and elderly patients. The cause of such reactions is often prolonged treatment. In childhood, complications from the liver practically do not occur. Most often, side effects are reversible.

The above symptoms make themselves felt during therapy or some time after its completion. Structural and functional disorders of the liver pose a danger.

Augmentin ® and alcohol

It is a well-known fact that antibiotic therapy and alcohol are two incompatible concepts. However, controversy among practicing doctors on this issue still does not subside. Let us immediately make a reservation that ethyl alcohol does not affect the concentration of Augmentin ® in the blood or the therapeutic effect.

It is quite difficult to assess the compatibility and possibility of concurrent use of the antibiotic Augmentin and alcohol, but it is possible to study the effect of drugs on certain organs and systems. The liver suffers the most, as it receives a double blow, because it is the liver that neutralizes toxic substances, which include ethanol and some pharmacological groups.

Drinking alcoholic beverages during antibiotic treatment contributes to the development of kidney failure. Moreover, in this case, the patient’s age does not matter; such combinations are deadly for all age groups.

During alcoholic libations, there is a narrowing of blood vessels, which can affect the distribution and transportation of the antibiotic.

The load increases not only on the organs of the hepatobiliary system, but also on the digestive organs. A person who simultaneously takes ethanol and Augmentin ® runs the risk of becoming a patient in the gastroenterology department, because the risk of:

• pancreatitis, to which dehydration of the body is added;
• acute hepatitis. A person may feel unwell in the first hours after drinking alcohol;
• erosion of the stomach and intestines. It is dangerous because the disease does not make itself felt for a long time;
• peptic ulcer, manifested by internal bleeding. Alcohol together with Augmentin can initiate the entry of blood into the natural cavity of the body.

Analogs and generics

• Amoxiclav Quiktab ® (from 360 to 600 rubles)
• Amoxiclav ® (from 250 to 550 rubles) -
• Arlet ® (from 230 to 560 rubles)
• Augmentin SR ® (from 650 to 900 rubles);
• Klamosar ® (from 370 to 530 rubles)
• Medoclav ® (from 210 to 310 rubles)
• Panklav ® (from 220 to 520 rubles)
• Ranklav ® (from 390 to 560 rubles)
• Rapiclav ® (from 330 to 450 rubles)
• Flemoklav Solutab ® (from 290 to 870 rubles)

Augmentin ®: reviews from doctors for children and adults

Doctors

Gastroenterologist

Augmentin ® is inexpensive and suitable for treating adults and children. The disadvantages include the fact that the antibiotic is a perishable medicine, and its shelf life is only seven days. In exceptional cases, patients experience antibiotic-associated diarrhea. Protected penicillin copes well with respiratory infections. The suspension has a pleasant taste due to the addition of food additives and flavorings.

Dentist

Augmentin ® is an original medicine, it fully meets safety standards, is produced in accordance with all quality standards, and goes through all stages of purification. The drug helps with systemic infections when the body is affected by several strains of bacteria. The drug is well tolerated. Clavulanic acid can inactivate a wider range of pathogens.

Therapists

Patients rarely complain of complications, but some develop dyspeptic symptoms. Persons receiving Augmentin ® should not forget about fungal infections, which are a faithful companion to long-term antibiotic therapy.

Otolaryngologist

Augmentin ® is suitable for all age groups. Indispensable in the treatment of infections of the ear, nose, and lower respiratory tract. A properly selected dosage regimen helps prevent the occurrence of adverse reactions. In adults, complications are extremely rare. It is more effective than unprotected penicillins, which are destroyed by bacterial enzymes.

The penicillin antibiotic Augmentin is approved for both adults and children. It is prescribed for many infections. But sometimes, young mothers do not wait for the doctor’s recommendations or, on the contrary, act contrary to them, replacing “Augmentin 400” with what the doctor prescribed. In this case, problems may arise with the correct dosage of the Augmentin 400 suspension for children. In order not to cause harm, but to truly benefit from a good and, in many cases, useful drug, you need to understand some of the intricacies.

Characteristics of the suspension "Augmentin 400"

"Augmentin 400" is developed on the basis of amoxicillin, a broad-spectrum antibiotic and clavulanic acid, which protects amoxicillin from destruction.

Amoxicillin is the main substance of the Augmentin 400 suspension. It is he who has a bactericidal and antibacterial effect on the body. The disadvantage of amoxicillin is that some microorganisms become addictive to it. This means that they simply stop responding to the drug. This is where clavulanic acid comes into play. It makes viruses less resistant.

Amoxicillin is an antibiotic of the penicillin group and is therefore well tolerated even by small children and pregnant women, except in cases of individual intolerance.

But it must be remembered that, like most medications, it has its side effects. And also, it is contraindicated in case of phenylketonuria, as well as in case of renal failure and liver diseases.

Augmentin suspension is prescribed for various respiratory tract infections, skin diseases, and genitourinary system diseases.

Taking Augmentin suspension also helps with osteomyelitis. It is an excellent prevention of infections in case of surgical operations.

How to prepare the Augmentin suspension and how to take it:

• The drug must be poured into a bottle and filled with boiled water. Attention! The water should not be hot;
• Next, you need to shake it well to maximize the dissolution of the granules and leave for 4 minutes. During this time, even the smallest particles will have time to dissolve.
• But if you see that this has not happened, then shake the bottle again and leave for another 5 minutes.
• Then you need to add water to the mark.
• Only after this the drug can be considered ready for use.
• The prepared suspension can be stored in the refrigerator for up to 7 days, but do not freeze. After 7 days, it is prohibited to use the drug.

When you remove the suspension from the refrigerator, you need to shake it well and pour the required amount into a measuring spoon. You can draw up the required volume of the drug using a syringe.

Don't forget that all items you use must be handled carefully. Under no circumstances should the suspension particles be allowed to dry on the spoon or syringe and used several times without washing.

If the child cannot drink the suspension, for example because the taste is unpleasant to him, it is allowed to add an amount of water. But at the same time you need to drink all this solution.

Dosage of Augmentin 400 suspension for children: instructions for independent calculation

The powdered drug "Augmentin" can be purchased in pharmacies in various versions, in which the concentration of amoxicillin and clavulanic acid is different:

• 125 mg amoxicillin + 31.35 mg clavulanic acid;
• 200 mg amoxicillin + 28.5 mg clavulanic acid;
• 400 mg amoxicillin + 57 mg clavulanic acid.

In all variants, the main dosage is 5 ml of the finished suspension. But you should know that the dosage of Augmentin 400 is always calculated based on the concentration of amoxicillin: 125, 200 or 400. This is important to understand in order to remember that these drugs do not replace one another. And if you were prescribed Augmentin 400, it cannot be replaced with Augmentin 200 or Augmentin 125 and vice versa.

Augmentin 400 suspension is usually prescribed for children over 12 years of age and adults. The child's body weight must be more than 40 kg. But use is contraindicated for children under 2 years of age. Augmentin 125 is just right for them.

The dosage of the Augmentin 400 suspension for children is individual - it is necessary to take into account body weight, severity of the disease, and age. The dosage is calculated only for amoxicillin.

If the drug is prescribed to a child under 12 years of age, then it is necessary to ensure that per 1 kilogram of body weight there is no more than 45 mg and no less than 25 mg of antibiotic.

The severity of the disease also plays a big role here. For example, for skin infections and chronic tonsillitis, antibiotic doses are minimal. But for acute infectious diseases, pneumonia, bronchitis, the total doses of the drug increase.

It is worth remembering that there is also the number of doses of the drug. For example, a child under 12 years of age can only be given 1 or 2 rubles. per day. And the break between two doses should be at least 12 hours.

Example of drug calculation:

Child 8 years old, weight - 27 kg. The disease is otitis media. He needs 45 mg of the drug per 1 kilogram of weight. This means that the total dosage of the drug will be 1215 mg, which will be divided into 2 doses - 607.5 mg each.

5 ml of Augmentin suspension contains 400 mg, which means that 7.6 ml, or 15 ml per day, must be taken per dose.

It is not very easy to calculate the exact dosage of Augmentin 400 suspension for a child. Because you need to do some math. Often, parents get confused about them, so there are average values. But it’s better to use these values ​​only as a hint. That is, check against them whether the calculations were made correctly.

For example, a child over one year old and weighing up to 18 kg should not take more than 5 ml of the finished Augmentin suspension. A child over 6 years old and 19 kg can already take 7.5 of the prepared suspension. If the child is already 10 years old and weighs more than 29 kg, then he needs 10 ml of suspension per dose. But these values ​​do not take into account the disease itself, nor its severity.

Abbott Nutrition Ltd SMITHKLINE BEECHAM BIOLOGICALS SMITHKLINE BEECHAM PHARMACEUTIKALS Glaxo Wellcome GmbH & Co Glaxo Wellcome Production GlaxoSmithKline Pharmaceuticals S.A. SmithKlein Beecham PLC SmithKlein Beecham Biologicals SmithKlein Beecham Limited SmithKlein Beecham Pharmaceuticals

Country of origin

Great Britain United Kingdom France

Product group

Antibacterial drugs

Broad-spectrum penicillin antibiotic with beta-lactamase inhibitor

Release forms

• 10 - blisters in aluminum foil bags (2) - cardboard packs. 11.5 g of powder - glass bottles with a volume of 100 ml (1) complete with a measuring cap - cardboard packs. 12.6 g of powder - glass bottles with a volume of 70 ml (1) complete with a measuring cap - cardboard packs. 23.13 g of powder - bottles (1) - cardboard packs. 28 tablets 7 - blisters in aluminum foil bags (2) - cardboard packs 7 - blisters in aluminum foil bags (2) - cardboard packs. 7 - blisters in aluminum foil bags (2) - cardboard packs. 10 - blisters in aluminum foil bags (2) - cardboard packs of 7.7 g of powder - glass bottles with a volume of 70 ml (1) complete with a measuring cap - cardboard packs Glass bottles (10) - cardboard boxes.

Description of the dosage form

• Powder for the preparation of a solution for intravenous administration from white to almost white. Powder for the preparation of a suspension for oral administration Powder for the preparation of a suspension for oral administration is white or almost white in color, with a characteristic odor; upon dilution, a white or almost white suspension is formed; when standing, a white or almost white precipitate slowly forms. Powder for the preparation of a suspension for oral administration is white or almost white, with a characteristic odor; upon dilution, a white or almost white suspension is formed; When standing, a white or almost white precipitate slowly forms. Powder for the preparation of a suspension for oral administration is white or almost white in color, with a characteristic odor; upon dilution, a white or almost white suspension is formed; When standing, a white or almost white precipitate slowly forms. Powder for the preparation of a suspension for oral administration is white or almost white in color, with a characteristic odor; the prepared suspension is white or almost white. Modified-release film-coated tablets White to off-white, oval, film-coated tablets with the letters "A" and "C" on both sides of the tablet and a break line on one side; at the break - from almost white to yellowish-white. Film-coated tablets are from white to almost white, oval, with the letters “A” and “C” on both sides of the tablet and a break line on one side; at the fracture - from almost white to yellowish-white. White to almost white, oval, film-coated tablets with the inscription "AUGMENTIN" imprinted on one side; at the fracture - from almost white to yellowish-white. White to almost white, film-coated tablets, oval, with embossed inscription "AC" and a score line on one side.

Pharmacological action

A combined broad-spectrum antibiotic, resistant to beta-lactamase, containing amoxicillin and clavulanic acid. Amoxicillin is a semisynthetic broad-spectrum antibiotic that is active against many gram-positive and gram-negative microorganisms. Amoxicillin is destroyed by beta-lactamases, so the spectrum of its antibacterial activity does not include microorganisms that produce beta-lactamases. Clavulanic acid is a beta-lactam compound that has the ability to inactivate a wide range of beta-lactamases, enzymes that commonly produce microorganisms resistant to penicillins and cephalosporins. The presence of clavulanic acid in Augmentin protects amoxicillin from the destructive action of beta-lactamases and expands the spectrum of its antibacterial activity to include microorganisms that are usually resistant to other penicillins and cephalosporins. Augmentin® is active against gram-positive aerobic microorganisms: Bacillis anthracis*, Corynebacterium spp., Enterococcus faecalis*, Enterococcus faecium*, Listeria monocytogenes, Nocardia asteroides, Staphylococcus aureus*, coagulase-negative staphylococci (including Staphylococcus epidermidis), Streptococcus spp. (including Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans); against gram-positive anaerobic microorganisms: Clostridium spp., Peptococcus spp., Peptostreptococcus spp.; against gram-negative aerobic microorganisms: Bordetella pertussis, Brucella spp., Escherichia coli*, Gardnerella vaginalis, Haemophilus influenzae*, Helicobacter pylori, Klebsiella spp.*, Legionella spp., Moraxella catarrhalis* (Branhamella catarrhalis), Neisseria gonorrhoeae*, Neisseria meningitidis *, Pasteurella multocida, Proteus mirabilis*, Proteus vulgaris*, Salmonella spp.*, Shigella spp.*, Vibrio cholerae, Yersinia enterocolitica*; against gram-negative anaerobic microorganisms: Bacteroides spp*. (including Bacteroides fragilis), Fusobacterium spp.*; for other microorganisms: Borrelia burgdorferi, Chlamydiae, Leptospira icterohaemorrhagiae, Treponema pallidum. *- some strains of these types of bacteria produce beta-lactamases, which causes resistance to amoxicillin monotherapy. Augmentin tablets, containing 500 mg amoxicillin and 125 mg clavulanic acid, are a sustained-release dosage form that differs from conventional tablets in other pharmacokinetic parameters. This ensures sensitivity to the drug for those strains of Streptococcus pneumoniae in which resistance to amoxicillin is mediated by penicillin-binding proteins (penicillin-resistant strains of Streptococcus pneumoniae).

Pharmacokinetics

The pharmacokinetic parameters of amoxicillin and clavulanic acid were obtained in different studies in healthy volunteers after taking on an empty stomach: 1 Augmentin tablet (250 mg/125 mg), or 2 Augmentin tablets (250 mg/125 mg), or 1 Augmentin tablet (500 mg/125 mg). ), or amoxicillin (500 mg), or clavulanic acid (125 mg) separately. When using Augmentin, plasma concentrations of amoxicillin are similar to those after oral administration of amoxicillin alone in equivalent doses. Absorption Amoxicillin and clavulanic acid dissolve well in aqueous solutions with a physiological pH value and after taking Augmentin orally they are quickly and completely absorbed from the gastrointestinal tract. Absorption of Augmentin's active substances is optimal when taken at the beginning of a meal. Distribution Therapeutic concentrations of both active substances are determined in various organs, tissues and body fluids (including lungs, abdominal organs; adipose, bone and muscle tissues; pleural, synovial and peritoneal fluids; skin, bile, urine, purulent discharge, sputum, interstitial fluid). Plasma protein binding is moderate: 25% for clavulanic acid and 18% for amoxicillin. Amoxicillin (like most penicillins) is excreted in breast milk. Trace amounts of clavulanic acid are also found in breast milk. With the exception of the risk of sensitization, there are no other known negative effects of amoxicillin and clavulanic acid on the health of breastfed infants. Experimental studies in animals have shown that amoxicillin and clavulanic acid penetrate the placental barrier. However, no fertility problems or negative effects on the fetus were detected. In animal studies, no accumulation of Augmentin ingredients was found in any organ. Metabolism and elimination Amoxicillin is eliminated primarily by the kidneys, while clavulanic acid is eliminated through both renal and extrarenal mechanisms. After a single oral dose of one tablet of 250 mg/125 mg or 500 mg/125 mg, approximately 60-70% of amoxicillin and 40-65% of clavulanic acid are excreted unchanged in the urine during the first 6 hours. About 10-25% of the initial dose of amoxicillin is excreted in the urine as inactive penicillic acid. Clavulanic acid in the human body undergoes intensive metabolism with the formation of 2,5-dihydro-4-(2-hydroxyethyl)-5-oxo-1H-pyrrole-3-carboxylic acid and 1-amino-4-hydroxy-butan-2-one and is excreted in urine and feces.

Special conditions

Before starting treatment with Augmentin, it is necessary to obtain a detailed history regarding previous hypersensitivity reactions to penicillins, cephalosporins or other allergens. Serious and sometimes fatal hypersensitivity reactions (anaphylactic reactions) to penicillins have been described. The risk of such reactions is highest in patients with a history of hypersensitivity reactions to antibiotics of this group. If an allergic reaction occurs, treatment with Augmentin should be discontinued and alternative therapy initiated. For severe hypersensitivity reactions, adrenaline (epinephrine) should be administered immediately. Oxygen therapy, IV steroids, and airway management, including intubation, may also be required. Use Augmentin® with caution in patients with impaired liver function. The severity of side effects from the digestive system can be reduced by taking Augmentin® at the beginning of a meal. Oral care helps prevent tooth discoloration by simply brushing your teeth. In patients receiving Augmentin®, an increase in prothrombin time is occasionally observed, and therefore, when using Augmentin and anticoagulants simultaneously, appropriate monitoring should be carried out. In patients with reduced diuresis, crystalluria very rarely occurs, mainly during parenteral therapy. When taking amoxicillin in high doses, it is recommended to take enough fluids and maintain adequate diuresis to reduce the likelihood of amoxicillin crystal formation. Long-term treatment with Augmentin may be accompanied by excessive growth of insensitive microorganisms. In general, Augmentin® is well tolerated and has the low toxicity characteristic of all penicillins. During long-term therapy with Augmentin, it is recommended to periodically monitor the functions of the kidneys, liver, and hematopoiesis. The suspension contains aspartame, which is a source of phenylalanine, and therefore these dosage forms should be used with caution in patients with phenylketonuria. There is no data in the medical literature about the abuse of Augmentin and about dependence on this drug. Effect on the ability to drive vehicles and operate machinery Augmentin® does not have a negative effect on the ability to drive vehicles and operate machinery.

Compound

• amoxicillin (as sodium salt) 1000 mg clavulanic acid (as potassium salt) 200 mg Each 1.2 g vial contains approximately 1 mmol K+ and 3.1 mmol Na+. amoxicillin (in the form of trihydrate) 125 mg clavulanic acid (in the form of potassium salt) 31.25 mg Excipients: xanthan gum, aspartame, succinic acid, colloidal silicon, hydroxypropyl methylcellulose, silicon dioxide, dry orange flavor 610271E (Tastemaker) and 9/027108 (Dragoco ), dry raspberry flavor NN07943 (Quest), dry flavor "Light molasses" 52927/AP (Firmenich). amoxicillin (in the form of trihydrate) 200 mg clavulanic acid (in the form of potassium salt) 28.5 mg Excipients: xanthan gum, aspartame, succinic acid, colloidal silicon, hydroxypropyl methylcellulose, silicon dioxide, dry orange flavor 610271E (Tastemaker) and 9/027108 (Dragoco ), dry raspberry flavor NN07943 (Quest), dry flavor "Light molasses" 52927/AP (Firmenich). amoxicillin (in the form of trihydrate) 250 mg clavulanic acid (in the form of potassium salt) 125 mg Excipients: magnesium stearate, sodium starch glycolate (type A), colloidal anhydrous silicon, microcrystalline cellulose. Shell composition: titanium dioxide, hydroxypropyl methylcellulose (5 cps), hydroxypropyl methylcellulose (15 cps), polyethylene glycol 4000, polyethylene glycol 6000, dimethicone (silicone oil). amoxicillin (in the form of trihydrate) 400 mg clavulanic acid (in the form of potassium salt) 57 mg Excipients: xanthan gum, aspartame, succinic acid, colloidal silicon, hydroxypropyl methylcellulose, silicon dioxide, dry orange flavor 610271E (Tastemaker) and 9/027108 (Dragoco ), dry raspberry flavor NN07943 (Quest), dry flavor "Light molasses" 52927/AP (Firmenich). amoxicillin (in the form of trihydrate) 500 mg clavulanic acid (in the form of potassium salt) 125 mg Excipients: magnesium stearate, sodium carboxymethyl starch, colloidal anhydrous silicon, microcrystalline cellulose. Shell composition: titanium dioxide, hypromellose (5 cps), hypromellose (15 cps), macrogol 4000, macrogol 6000, dimethicone 500 (silicone oil) amoxicillin (in the form of trihydrate) 875 mg clavulanic acid (in the form of potassium salt) 125 mg Excipients : magnesium stearate, sodium starch glycolate (type A), colloidal anhydrous silicon, microcrystalline cellulose. Shell composition: titanium dioxide, hydroxypropyl methylcellulose (5 cps), hydroxypropyl methylcellulose (15 cps), polyethylene glycol 4000, polyethylene glycol 6000, dimethicone (silicone oil). Amoxicillin 1000 mg, clavulanic acid 62.5 mg; Auxiliary ingredients: MCC, sodium carboxymethyl starch, anhydrous colloidal silicon dioxide, magnesium stearate, magnesium stearate Amoxicillin 600 mg + clavulanic acid 42.9; Auxiliary ingredients: xanthan gum, aspartame, silicon dioxide, colloidal silicon dioxide, carmellose sodium, strawberry flavoring

Augmentin indications for use

• The combination of amoxicillin with clavulanic acid is indicated for the treatment of bacterial infections of the following localizations caused by microorganisms sensitive to the combination of amoxicillin with clavulanic acid: Upper respiratory tract infections (including infections of the upper respiratory tract), for example, recurrent tonsillitis, sinusitis, otitis media, usually caused by Streptococcus pneumoniae, Haemophilus influenzae#, Moraxella catarrhalis# and Streptococcus pyogenes. Lower respiratory tract infections, such as exacerbations of chronic bronchitis, lobar pneumonia and bronchopneumonia, usually caused by Streptococcus pneumoniae, Haemophilus influenzae# and Moraxella catarrhalis#. Infections of the genitourinary tract, for example, cystitis; urethritis, pyelonephritis, infections of the female genital organs, usually caused by species of the family Enterobacteriaceae# (mainly Escherichia coli#), Staphylococcus saprophytics and species of the genus Enterococcus, and gonorrhea caused by Neisseria gonorrhoeae Skin and soft tissue infections, usually caused by Staph

Augmentin contraindications

• - hypersensitivity (including to cephalosporins and other beta-lactam antibiotics); - infectious mononucleosis (including when a measles-like rash appears); - phenylketonuria; - a history of episodes of jaundice or impaired liver function as a result of the use of amoxicillin/clavulanic acid; - CC less than 30 ml/min (for tablets 875 mg/125 mg). With caution: pregnancy, lactation, severe liver failure, gastrointestinal diseases (including a history of colitis associated with the use of penicillins), chronic renal failure.

Augmentin dosage

• 1000 mg + 200 mg 1000 mg + 62.5 mg 125 mg/31.25 mg in 5 ml 125 mg/31.25 mg/5 ml 200 mg/28.5 mg in 5 ml 250 mg/125 mg 250 mg/125 mg 400 mg /57 mg in 5 ml 500 mg + 125 mg 500 mg + 100 mg, 1000 mg + 200 mg 600 mg + 42.9 mg/5 ml 875 mg/125 mg 875 mg/125 mg

Augmentin side effects

• The adverse events presented below are listed according to the damage to organs and organ systems and the frequency of occurrence. The frequency of occurrence is determined as follows: very often (>1/10), often (>1/100 and 1/10000 and 1/10000 and

Drug interactions

Probenecid and similar drugs (diuretics, phenylbutazone, NSAIDs) reduce the tubular secretion of amoxicillin. The simultaneous administration of these drugs is not recommended and may be accompanied by an increase in the concentration and persistence of amoxicillin in the blood, while the renal excretion of clavulanic acid does not slow down. In patients receiving Augmentin®, an increase in prothrombin time is rarely observed, and therefore, when used simultaneously with anticoagulants, appropriate monitoring should be carried out. Concomitant use with allopurinol may cause allergic skin reactions. Currently, there is no data in the literature on the simultaneous use of Augmentin and allopurinol. Augmentin® may reduce the effectiveness of oral contraceptives (patients should be informed about this). Pharmaceutical interactions Augmentin® must not be mixed with blood products, other protein solutions, such as protein hydrolysates, and lipid emulsions.

Overdose

Gastrointestinal disorders and disturbances in water and electrolyte balance are possible. Amoxicillin crystalluria has been described, in some cases leading to the development of renal failure.

Storage conditions

• store at room temperature 15-25 degrees
• keep away from children

Information provided