Alpha tocopherol acetate solution in oil application. Instructions for use and contraindications of vitamin E oil solution

Contents:

What pharmacological properties does the oil solution of vitamin E have? What effect does it have on the body?

Vitamin E (tocopherol) is a vital element for the body that improves blood flow, the condition of blood vessels, and optimizes the functioning of muscle tissue and internal organs. One of the forms in which vitamin E is produced is an oil solution. Instructions for use of the drug are discussed below.

Form and composition

The drug "Alpha-tocopherol acetate" has the form of an oil solution and is intended for oral administration.

Vitamin E - 0.05 g, 0.1 or 0.3 mg(5, 10 and 30 percent respectively).
Auxiliary elements - sunflower oil (refined, deodorized or refined).

Description and pharmacological properties

Vitamin E is an oily liquid that is odorless and has a light yellow (sometimes greenish) tint.

Tocopherol is a fat-soluble substance, the functionality of which and its effect on the body have not been fully determined. It has been proven that vitamin E (solution in oil) - powerful antioxidant, preventing the formation of peroxides that damage the membranes of cells in the human body. The substance has a positive effect on the muscular and nervous system. In combination with selenium, tocopherol suppresses the oxidation of non-oxidized fatty acids and eliminates the risk of hemolysis of red blood cells. The element is also a cofactor of a number of enzyme systems.

After taking vitamin E orally, the substance is absorbed from the duodenum. The process occurs with the participation of fats, salts and bile acids. For complete absorption of vitamin E, normal functioning of the pancreas is required. Depending on the state of the body, the level of digestibility is 50-80% from the volume entered into the body.

Subsequently, tocopherol binds to lipoproteins in the blood plasma and spreads throughout the body. If protein metabolism is disrupted, the transfer of fat-soluble substances is disrupted. The highest concentration after administration is achieved after four hours. The peculiarity of the vitamin is its ability to accumulate in adipose tissue, tissues and organs. During the period of bearing a child 20-30 percent tocopherol enters the blood of the fetus. In addition, vitamin E is contained in breast milk, which eliminates the deficiency of the substance in the child during feeding (if the mother receives a sufficient portion of tocopherol).

The substance is processed in the liver to derivatives that carry vitamin activity. After this, the substance is excreted along with bile and through the kidneys (90 and 6 percent, respectively). The remaining part is reabsorbed with subsequent enterohepatic circulation. The process of tocopherol elimination is long, and it takes the longest in newborns.

Effect on the body

After entering the body, vitamin E ( 10, 5 and 30 percent) has a diverse effect:

Makes blood vessels more flexible.
Protects muscle fibers (including the heart) from dystrophic changes.
Prevents premature oxidative processes.
It has a positive effect on reproductive function and increases the likelihood of conception.
Increases libido and activates the functioning of sperm.
The production of hemoglobin and blood cells is triggered, which contributes to the renewal of blood plasma.

Indications for use

Vitamin E is prescribed with increased need for a substance:

low birth weight or prematurity;
peripheral neuropathy;
abetalipoproteinemia;
necrotizing myopathy;
celiac disease;
obstructive jaundice;
Crohn's disease;
cirrhosis of the liver;
biliary atresia;
chronic cholestasis;
malabsorption;
parenteral nutrition;
pregnancy;
addiction;
nicotine addiction;
lactation period;
diets high in polyunsaturated acids;
taking mineral oils, colestipol and cholestyramine.

A drug prescribed to newborns with low body weight in order to prevent the following diseases:

retrolental fibroplasia;
bronchopulmonary dysplasia;
hemolytic anemia.

Contraindications

In the process of receiving contraindications must be taken into account vitamin E. Instructions for use do not recommend taking the drug in the following cases:

hypersensitivity to tocopherol;
myocardial infarction;
violation of blood clotting processes;
risk of thromboembolism;
cardiosclerosis.

It should be taken with caution in case of hypoprothrombinemia. In case of a lack of vitamin K, the problem may worsen (provided the dosage of tocopherol is exceeded by more than 300 mg).

Directions for use and dosage

Before taking the course, you should figure out how to take liquid vitamin E orally and what the dosage should be.

Alpha-tocopherol acetate is prescribed in liquid form with different percentages of the active substance (5, 10 and 30 percent). Moreover, 1 ml of liquid contains 50, 100 and 300 mg of tocopherol, respectively. In terms of volume, 1 ml of the substance corresponds to 30 drops made from an eye dropper.

Minimum daily dosage - 10 mg.

Therapeutic norm for prevention and treatment:

Prevention of hypovitaminosis - 10 mg per day (5 percent solution).
Treatment of hypovitaminosis - 10-40 mg per day (10% solution).
Amyotrophic lateral sclerosis, muscular dystrophies, central nervous system diseases - 50-100 mg per day (10% solution). The course of treatment is 1-2 months, after which a break is taken for 60-90 days.
Violation of male potency, spermatogenesis - 100-300 mg(30 percent solution). The drug is prescribed in combination with hormonal therapy.
Threat of miscarriage - 100-150 mg(30 percent solution). Course - 1-2 weeks.
For problems during fetal development or after an abortion - 100-150 mg. A 30% solution is taken every day for 1-2 weeks or once every two days for the first 60-90 days of pregnancy.
For skin diseases - 50-100 ml(a 10 percent solution is used). Frequency of administration: 1-2 times a day. Course duration is 20-40 days.
Atherosclerosis, peripheral vascular disease, myocardial dystrophy. Injected with retinol 100 mg each(vitamin E 30 percent - ten drops, for a 10 percent solution - 30 drops). Treatment lasts 20-40 days, after which a break of 3-6 months is taken.
Decreased capillary resistance, malnutrition of infants - 5-10 mg(5 percent solution). For prevention - 10 mg. Frequency of administration - once a day, course 7-21 days.
Therapy of heart and eye diseases - 50-100 ml(10% solution). Frequency of administration: 1-2 times a day. Reception lasts 7-21 days.

Side effects and overdose

During use, you may experience allergic reactions on active substances. An overdose is possible if you take 330-660 mg per day. Symptoms:

blurred vision;
dizziness;
nausea;
fatigue;
diarrhea;
asthenia.

In case of admission more than 660 mg Over a long period of time, the following problems are possible:

the appearance of bleeding (manifests against the background of vitamin K deficiency);
problems in the sexual sphere;
disturbance of metabolic processes in thyroid hormones;
thrombophlebitis;
thromboembolism.

Interaction with other drugs

How to take liquid vitamin E in combination with other medications? Here The following recommendations apply:

When taken together with retinol, absorption increases and the toxicity of the latter decreases.
Increased intake of tocopherol over a long period can lead to a lack of vitamin A in the body.
When used together, tocopherol reduces the toxicity of vitamin D.
The combined use of vitamin E in a dosage exceeding 330 mg per day with indanedione and coumarin derivatives leads to an increased risk of bleeding and hypoprothrombinemia.
Increased doses of iron accelerate oxidation processes in cells, which leads to tocopherol deficiency.
The presence of mineral oils, colestipol and cholestyramine in the body impairs the absorption of vitamin E.
Concomitant use with silver preparations and alkaline-reactive agents is prohibited.
Tocopherol has an antagonistic effect on vitamin K.
In the case of taking vitamin E and anti-inflammatory drugs (steroidal and non-steroidal types), the effect of the latter is enhanced.
Alpha-tocopherol acetate oil solution reduces the toxicity of digoxin and digitoxin.
Vitamin E increases the effectiveness of drugs prescribed to combat epilepsy.

Specific instructions

Instructions for use of vitamin E (in oil) describe all requirements regarding dosage and administration of the substance. At the same time, it is worth considering a number of points:

Tocopherol is found in green plants (cereal sprouts) and oils (soybean, peanut, corn and others). There is also a small amount of vitamin E present in milk, eggs, fat and meat.
In newborns, tocopherol hypovitaminosis is possible due to low placental permeability.
During diets with increased consumption of amino acids and selenium, a decrease in the daily intake is allowed.

To date, it has been proven that treatment with vitamin E ineffective in the following cases:

oncological diseases;
hair loss;
heart disease;
burns;
diaper dermatitis;
infertility;
leptic ulcer and other diseases.

Taking tocopherol is also ineffective for increasing sexual activity.

Storage conditions and shelf life

Liquid alpha-tocopherol acetate is stored for 2 years. Storage conditions:

temperature - 15-25 degrees Celsius;
lack of light and high humidity;
protection from children;
Contents in original packaging.

Liquid vitamin E in cosmetology

Tocopherol in oil form is used in cosmetology to eliminate problems with the skin of the face and body, remove wrinkles and other signs of aging.

Vitamin E solution is used internally and externally, as a common element of face masks. Its action:

Slowing down the aging processes that are activated after reaching 25 year old age.
Smoothes existing wrinkles and protects against new signs of aging.
Acceleration of cell regeneration processes.
Activation of the production of elastin fibers and collagen.
Restoration of cells of the respiratory organs.
Tightening effect.

In addition, tocopherol also has a number of protective functions, among which:

Removing dangerous toxins from the skin.
Elimination of foci of inflammation.
Strengthening cell membranes.
Destroys dangerous free radicals.

Internal intake of vitamin E in combination with masks is often prescribed for:

Prevention of aging.
Acne treatment.
Neutralization of dangerous pigmentation due to UV rays or hormonal imbalance.
Toning the epidermis.
Elimination of sagging, atony of the skin, wrinkles.

Vitamin E is a savior for women and men who dream of good health and preservation of youth. The main thing is to strictly adhere to the instructions for use, take into account contraindications and not exceed the prescribed dosages.

Translated from Latin, the name of vitamin E (aka tocopherol) is translated as “promoting birth.” And this name is fully justified - indeed, women and men often use medicinal complexes based on it to restore fertility.

But, in addition to the blessing of the birth of a new life, this vitamin also has a lot of valuable properties for female beauty.

Representatives of the fair sex who regularly eat foods containing it remain young and beautiful much longer than their peers who do not attach special importance to proper fortified nutrition.

And if you use a tocopherol solution externally, purely for cosmetic purposes, you can achieve visible rejuvenation in the shortest possible time.

Most often, vitamin E is used by women in the preparation of nourishing and regenerating face masks. These masks are prepared independently, at home, and their recipes are not difficult at all. They usually contain products that each of you has in your home. If you regularly use such skincare products, you are guaranteed to look like a queen.

So, how to properly use vitamin E for face masks, and what are its beneficial effects?

Tocopherol: how is it beneficial for facial skin?

For external use of vitamin E, an oil solution is sold in pharmacies and large pharmaceutical chains. Using it to provide competent facial skin care is simple and pleasant. Busy women who lack free time simply apply it to cleansed skin in the evening, using it purely as a night cream.

If you have a free hour during the day, we advise you to try masks based on this solution. Since their ingredients interact with each other, complementing each other, the effect is achieved even faster and is much more pronounced.

Let's figure out why vitamin E is so beneficial for the dermis and epidermis?

The role of tocopherol for facial skin is extremely important and is not exaggerated at all. The first and main effect that this vitamin provides is to give firmness and increase elasticity. Without sufficient intake of this nutrient into the body, the skin begins to age quickly. It becomes flabby, extremely susceptible to gravitational ptosis, dehydrated and wrinkled.

Even muscle structures cease to be elastic without this important element. Therefore, under the influence of the law of attraction, without proper "recharge" they also start "stretch" to the ground along with the skin. The result is a floating oval of the face, often prematurely.

To keep your skin in good condition, you must consume a sufficient amount of tocopherol orally (daily value). It is 100 mg of the substance per day. It can be found in such quantities in food products, but if you have doubts about the quality of modern products that you purchase in markets or supermarkets, consult your doctor about taking multivitamin and multimineral complexes.

It should be emphasized here that tocopherol is a fat-soluble vitamin, the resources of which are constantly present in your body.

Therefore, its persistent excess can also negatively affect your health, like a deficiency. It is not recommended for anyone to take vitamins A and E in their pure form without a prescription.

It will be better for your facial skin if you use tocopherol topically, externally. You can use it as a mask, mixing it with other nourishing ingredients, or apply it instead of a night cream in its pure form. Don't worry - you won't overfeed your skin even if you use the solution on a daily basis. She will only benefit from this. True, you shouldn’t overdo it either - it’s important to calculate the course and stick to it from the beginning.

In addition to a mask with concentrated vitamin E, you can enrich your usual caring cream with its solution. If you drive the entire ampoule of the vitamin into it, you will have to store the resulting product in the refrigerator. It is better to add oil to the original composition of the cream in portions.

What effect can you get?

An oil solution of vitamin E for the face will provide you with the following benefits:

To enhance the effect of tocopherol, you can choose a solution of combined vitamins. For example, women highly praise the effect of masks with vitamins C and E. Some prefer to use solutions of retinol and tocopherol, which most harmoniously complement each other from a biological and chemical point of view.

The best recipes for face masks with the addition of tocopherol

We figured out how beneficial vitamin E affects the skin. But how to use it correctly if you are not going to do it in its pure form? Try a vitamin E mask at home! Its preparation and use will not take much effort and time, and the result is guaranteed to please and pleasantly surprise you.

Mask for restoring and nourishing dry skin:

Grind a tablespoon of cottage cheese through a sieve to make the mass soft and pliable;
Add a little warmed sour cream (quite fatty) so that the mixture turns out plastic and slightly liquid;
Add half an ampoule of concentrated vitamin E to the mass (or the contents of several capsules of the drug "Aevit");
Apply the resulting composition in a thick layer onto the cleansed and steamed surface of the face;
Leave for at least half an hour;
Wash off the mask with warm water without soap or other cleansers containing aggressive ingredients.

Rejuvenating and nourishing mask:

Moisturizing mask:

Grate some fresh cucumber pulp on a fine grater;
Add a tablespoon of oil solution of vitamins A and E into the mixture;
Enrich the mixture with biostimulated aloe vera juice (you can use a ready-made pharmacy version);
Apply to a clean, steamed face for twenty minutes;
Rinse with warm water without soap.

You can also use ready-made masks if you have your favorite formulations. Just add a couple of drops of oil (about one teaspoon or coffee spoon) to your usual portion of the skincare product, then stir directly in your hand and apply to prepared, cleansed skin.

It is very useful to use the vitamin to care for the delicate and thin skin of the eyelids. In order not to weigh it down with oil, the solution must be diluted with something. For this purpose, your usual cream or gel for restoring the skin around the eyes will be useful.

Every adult knows how important vitamins are for the normal functioning of the human body. It is known that a deficiency of certain substances can provoke serious disturbances in the functioning of vital organs. In fact, a lack of vitamins also affects the condition of the skin of the face, since it is a kind of indicator signaling that certain changes are occurring in the functioning of the body. That is why the skin needs special care and, first of all, regular nutrition, because the older it gets, the more difficult it is for it to cope with the body’s internal reserves alone.

One of the most important substances for the health and beauty of the skin is vitamin E (tocopherol) - a powerful antioxidant that protects cells from free radicals, participates in the restoration of cell membranes and helps retain moisture in skin cells. Vitamin E can be obtained from food, as well as from medications that are sold in any pharmacy. One of these drugs is alpha-tocopherol acetate, produced in several forms: in the form of oil solutions (for injection and oral administration) and spherical gelatin capsules.

Effect of tocopherol on facial skin

Tocopherol is not without reason called the vitamin of youth, because it really slows down the aging process in skin cells, improves their nutrition, promotes tissue regeneration and normalizes the metabolism of collagen fibers. In addition, vitamin E protects other fat-soluble compounds from oxidation, helps absorb vitamins (particularly vitamin A), and controls the production of sex hormones, which have a significant impact on the condition of the skin. The use of tocopherol for the face as a cosmetic product is justified by the complex effect it has on the skin:

promotes active cell renewal;
protects epidermal cells from free radicals;
removes toxins;
eliminates pigmentation;
increases the protective functions of the skin;
eliminates oxygen starvation of cells;
improves blood circulation;
restores water-fat balance;
increases skin elasticity;
eliminates foci of inflammation;
reduces skin rashes;
tightens the oval of the face;
soothes irritated skin, eliminating itching and flaking;
smoothes expression wrinkles;
gives the skin a boost of energy, relieves fatigue and improves complexion;
prevents aging and promotes rejuvenation of epidermal cells;
prevents the formation of cancer cells.

Since vitamin E is not produced by the body (this substance is synthesized only by plants), it can only be obtained from food. But unfortunately, the usual diet of almost any modern person does not provide a sufficient amount of tocopherol, so you need to compensate for its deficiency yourself, including vegetable oils (unrefined), nuts, seeds, seafood, Brussels sprouts, berries and legumes in your daily menu. If necessary, you can take vitamin E in capsules or tablets.

Indications for the use of tocopherol for the face

Alpha tocopherol acetate for the face can be used externally - as part of masks, creams and other cosmetics, and as a medicine. Any method will be quite effective if the dosage and indications for use of this drug are observed:

vitamin E can be used for preventive purposes for young skin to prevent its early aging;
at the first signs of fading, such as the appearance of wrinkles and age spots;
as a rejuvenating agent for mature skin;
to eliminate signs of fatigue;
with excessive pigmentation;
for problematic skin prone to acne and frequent inflammation.

Contraindications for taking this drug orally (orally or by injection) are serious diseases of the internal organs, pregnancy and individual intolerance. There are no contraindications for external use; in rare cases, allergic reactions may occur, so before using any form of tocopherol you need to conduct a sensitivity test.

Methods of using tocopherol for facial skin

For cosmetic purposes, you can use several forms of tocopherol: capsules with an oily liquid (they are pierced with a needle and the contents are squeezed out), a 50% solution of alpha-tocopherol acetate and vitamin E in ampoules. Any of the listed forms is suitable for external use as a vitamin supplement to various cosmetics or in its pure form. In order to saturate your facial skin with beneficial vitamins and improve its condition, you can use several methods.

Rubbing into the skin

This option for using tocopherol is perhaps the simplest, but nevertheless quite effective. Vitamin E can be rubbed in pure form or as part of a solution (water or oil).

The drug should simply be applied in a thin layer to problem areas of the skin using a cotton pad (pre-pierced capsules can also be used for these purposes). It should be noted that vitamin E should be applied very carefully to the skin around the eyes to avoid irritation and redness. In addition, tocopherol acetate cannot be mixed with essential oils and saline solutions - such mixtures can provoke allergic reactions.

Homemade glycerin-based cream

Face cream with tocopherol and glycerin can be used for all skin types and even sensitive ones, because this home remedy does not contain preservatives or fragrances. In addition, it is affordable and can easily replace store-bought analogues.

In order to prepare vitamin cream, you need to take 80 g of glycerin, 5-7 drops of vitamin E and 50 ml of chamomile decoction. All components should be thoroughly mixed and the finished mass should be transferred to a clean jar. The mixture can be stored for no more than three days in a cool place. It is better to use this remedy immediately before bedtime. Instead of chamomile, you can add any medicinal herbs depending on your skin type.

Addition to various oils

Vitamin E is often found in industrial cosmetics, but it can also be added to prepared creams and oils. For dry, flaking-prone skin, it is advisable to use almond, olive or peach oil, to which tocopherol should be added in a ratio of 1:10. For oily skin, oil mixtures are not recommended. After applying the composition, you do not need to wash your face; if necessary, you can remove excess oil with a dry cotton pad.

Vitamin E face masks

One of the most effective ways to use vitamin E externally at home is through face masks. Such cosmetics will help moisturize the skin, give it a healthy glow, soothe, soften and eliminate inflammation. The ingredients for preparing masks should be selected according to your skin type and the problems that need to be solved. Preparing vitamin masks is not at all difficult, but to achieve the desired result, you must consider the following rules:

It is advisable to apply masks to clean, pre-steamed skin using a herbal bath or hot towel;
the vitamin mixture should be distributed on the skin in a fairly thick layer strictly along the massage lines;
During the procedure, you need to lie down in a comfortable position and relax the muscles on your face as much as possible;
the duration of action of vitamin formulations is at least 15 minutes;
To remove the mask, you can use warm water or herbal decoction.
After the procedure, it is recommended to apply any nourishing cream to your face.

The frequency of procedures is usually 1–2 times a week (a total of at least 10 sessions should be performed), after which it is recommended to take a break for 2–3 months.

Mask recipes

Oatmeal mask with vitamin E for oily skin

50 g oatmeal;
20 ml lemon juice;
5–6 drops of tocopherol oil solution.

Grind the rolled oats into flour using a coffee grinder.
Add lemon juice and vitamin, mix everything and apply a thick layer of the mask on your face for about a quarter of an hour.
Rinse off the composition with water and gently pat your face with a napkin.

This mask will eliminate oily shine and prevent acne.

Protein mask with honey for combination skin

1 egg white;
80 g liquid honey;
1 ml tocopherol.

Preparation and use:

Beat the egg whites until foamy, add honey (warm) and vitamin preparation.
Mix and apply the mixture to your face.
After 20 minutes, wash off the protein mask as usual. There is no need to use cream after the procedure.

The skin becomes matte, smooth and becomes more elastic.

Curd mask with almond oil for dry skin

50 g cottage cheese;
1 ampoule of vitamin E;
30 ml almond oil.

Preparation and use:

Grind the cottage cheese with butter until smooth.
Add liquid vitamin E, mix and gently spread the resulting mixture on your face.
After 20 minutes, remove the mask using a damp sponge.

This mask wonderfully refreshes the skin, eliminates flaking and returns a healthy color.

Rejuvenating mask with oatmeal and peach

1 small peach (fresh);
30 g oat flour;
30 g honey;
5-6 drops of tocopherol.

Preparation and use:

Peel the peach, cut in half and place in the microwave or oven for a few minutes. The fruit should become soft.
Grind the peach pulp in a blender, add flour and honey.
Stir and add tocopherol to the resulting mass.
Distribute the mask evenly on your face and leave for half an hour.
Rinse off the vitamin composition with water and apply a tightening cream to the skin.

Nourishing mask with sour cream and aloe juice

50 g fat sour cream;
20 ml aloe juice;
1 ampoule of tocopherol and vitamin A.

Preparation and use:

Add aloe juice and vitamins to sour cream.
Mix and distribute the nourishing mass on the skin.
Cover your face with a napkin and lie there for 30 minutes.
Rinse off the composition with water and use a nourishing cream.

This product fills the skin with energy, smoothes wrinkles and eliminates inflammation.

Moisturizing mask with glycerin and parsley

30 ml glycerin;
20 ml parsley juice;
50 ml heavy cream;
1 ml tocopherol;
30 g blue clay.

Preparation and use:

Mix glycerin, liquid vitamin and cream separately.
Place the clay in another container, add parsley juice and grind until smooth.
Combine both masses, mix and carefully distribute the mixture on your face.
After 20 minutes, remove the glycerin composition with a cotton pad and apply a light texture moisturizer to the skin.

Using alpha tocopherol acetate on the face, you can achieve really good results. Moreover, this drug has practically no contraindications, but has a lot of useful properties, thanks to which you can preserve the natural beauty of the skin and significantly prolong its youth.

Capsules and oil solution of tocopherol acetate 30% for oral use.

pharmachologic effect

The medicine serves to replenish the lack of vitamin E in the body. Antioxidant .

Pharmacodynamics and pharmacokinetics

Alpha-Tocopherol acetate (vitamin E) is involved in tissue metabolism. This remedy warns and the appearance of peroxides, which can damage cellular and subcellular membranes. Prevents free radical reactions, the appearance of degenerative-dystrophic changes in skeletal muscles and cardiac muscle, disruption of the testicles and seminiferous tubules, as well as placenta . In addition, it prevents an increase in permeability and fragility, improves reproductive function. Normalizes nutrition and contractility myocardium , tissue respiration. Reduces consumption myocardium oxygen. Helps in synthesis gem And heme-containing , as well as in protein synthesis. Protects against oxidation. Prevents oxidation Selena and unsaturated fatty acids. Blocks synthesis.

Tocopherol acetate for the face, when used regularly, can achieve the following results:

slowing down aging - the skin stays tight and elastic longer, without wrinkles;
healing of damaged areas - wounds heal much faster;
warning oncological diseases;
improved protection of the skin from ultraviolet rays - redness, burns and other reactions that can be triggered by sunlight appear less frequently;
normalization of skin condition - tocopherol prevents flaking, reduces skin oiliness and helps control skin function sebaceous glands , it also saturates cells with oxygen and promotes regeneration. Skin looks healthier and more attractive without surgery.

The drug after oral administration slowly absorbed by about 50%. The maximum concentration is observed after 4 hours. Bile acids are needed for absorption. At absorption a complex is being created with lipoproteins – intracellular tocopherol transporters.

The active component enters first into, and then into the general bloodstream, in which it binds mainly to alpha1- And beta lipoproteins and, partly, with whey. Accumulates in the adrenal glands, testes, muscle tissue, liver, lipid tissue , . It is broken down and excreted from the body mainly with bile. A certain amount of the drug is excreted in the urine.

Indications for use

This medicine is used for hypovitaminosis , heavy physical activity, diseases of the ligamentous apparatus and muscles, conditions convalescence after illnesses with febrile syndrome , in old age. In addition, it helps in case of climacteric vegetative disorders , asthenic neurasthenic syndrome , post-traumatic myopathy , neurasthenia when overworked, primary muscular dystrophy , post-infectious secondary myopathy , degenerative And proliferative changes in the joints and ligaments of the spine.

Contraindications

The medicine should not be used if hypersensitivity to its components, .

It should be used with caution in cases of hypoprothrombinemia .

Side effects

When using this remedy, pain in the epigastrium . In case of intramuscular administration - infiltrate at the injection site, pain.

Instructions for use of Tocopherol acetate (Method and dosage)

The usual dosage is 100-300 mg daily. If necessary, it can be increased to 1 g per day.

Instructions for use of Tocopherol acetate indicate that the exact doses and duration of the course are selected depending on the purpose of administration:

for prevention, take 100 mg 1-2 times every day, the course lasts 1-3 weeks;
violation spermatogenesis – take 100-300 mg every day as part of hormonal therapy, the course is designed for a month;
– every other day you need to take 300-400 mg. You should start on the 17th day of the cycle and continue for five cycles;
climacteric autonomic disorders – 100 mg 3 times/day;
anemia – 200 mg per day;
hypertension due – 100 mg in the first trimester every day or every other day;
liver disease with periods of exacerbation - take 300 mg per day for several months;
diseases of the neuromuscular system - take 100 mg daily, treatment lasts 1-2 months, the course can be repeated after 2-3 months;
problems with the menstrual cycle in adolescence before starting hormonal therapy - you need to take 100 mg 1-2 times a day, treatment lasts 2-3 months;
threat of interruption pregnancy – take 100 mg daily or every other day in the first trimester;
neurasthenia due to fatigue - take 100 mg daily, treatment lasts 1-2 months;
skin diseases – 100 mg per day for 20-40 days.

Overdose

In case of drug overdose, possible creatinuria , decreased performance, pain in epigastrium . The drug is canceled and prescribed glucocorticoids and carry out symptomatic treatment. There is nothing specific.

Interaction

Combination with and Dicoumarol may lead to a change in their action. The effectiveness of medicines containing iron may be reduced. Use with increases its absorption.

Terms of sale

Over the counter.

Storage conditions

The drug should be kept in a dark place, the optimal temperature is 18–20 °C. Keep away from children.

Best before date

Two years.

Alpha Tocopherol Acetate – Reviews

People often try to find out about Tocopherol, what it is and how to take it on the Internet. This product is recommended not only by experts, but also by those who have already tried it on themselves. You won't find any negative opinions about him. Everyone calls the medicine Alpha Tocopherol Acetate effective - it receives extremely positive reviews. They are especially often left by women who took the drug to normalize menstrual cycle or during pregnancy . They note that it is much more accessible than analogues with vitamin E.

Oral oil solution 5%: fl. 20 ml

Oily oral solution 5%

Excipients:

Oral oil solution 10%: fl. 20 ml
Reg. No.: 6334/03/08 dated 06/28/2008 - Canceled

Oral oil solution 10% from light yellow to dark yellow, transparent, without rancid odor; A greenish tint is allowed.

Excipients: Refined sunflower oil or refined deodorized sunflower oil, brand "P", frozen.

20 ml - bottles (1) - packaging.

Oral oil solution 30%: fl. 20 ml
Reg. No.: 6334/03/08 dated 06/28/2008 - Canceled

Oral oil solution 30% from light yellow to dark yellow, transparent, without rancid odor; A greenish tint is allowed.

Excipients: Refined sunflower oil or refined deodorized sunflower oil, brand "P", frozen.

20 ml - bottles (1) - packaging.

Description of the drug ALPHA TOCOPHEROL ACETATE (VITAMIN E) oil solution for oral administration created in 2010 on the basis of instructions posted on the official website of the Ministry of Health of the Republic of Belarus. Update date: 04/20/2011

pharmachologic effect

Vitamin E is an antioxidant that protects various endogenous substances in the body from oxidation. Inhibits lipid peroxidation, which is activated in many diseases. Takes part in the processes of tissue respiration, biosynthesis of heme and proteins, metabolism of fats and carbohydrates, cell proliferation, etc. With vitamin E deficiency, degenerative changes develop in the muscles, capillary permeability and fragility increase, the epithelium of the seminiferous tubules and testicles degenerates, and degenerative processes are observed in the nervous tissue and hepatocytes. Vitamin E deficiency can cause hemolytic jaundice of newborns, malabsorption syndrome, and steatorrhea.

Pharmacokinetics

The drug is absorbed in the intestine in the presence of fat and bile acids; the mechanism of absorption is passive diffusion. Transported as part of blood b-lipoproteins, the maximum concentration is reached by the 4th hour after administration. It is excreted in feces and conjugants and tocopheronic acid are excreted in urine.

Indications for use

Vitamin E hypovitaminosis, treatment of muscular dystrophies of various types and origins, dermatomyositis, Dupuytren's contracture, amyotrophic lateral sclerosis, psoriasis, to increase the effectiveness of anticonvulsants for epilepsy.

Dosage regimen

Alpha-Tocopherol acetate (Vitamin E) is prescribed orally.

The drug is used internally in the form of 5%, 10% and 30% oil solutions. 1 ml of solution contains 0.05 g, 0.1 g and 0.3 g of alpha-Tocopherol acetate, respectively (1 ml of solution contains 30 drops from an eye pipette). The daily requirement is 0.01 g per day.

To prevent hypovitaminosis E in adults, take up to 0.01 g (6 drops of a 5% solution) per day. For the treatment of hypovitaminosis E, take from 0.01 g to 0.04 g (3-12 drops of 10% solution) per day.

For muscular dystrophies, amyotrophic lateral sclerosis, and other diseases of the neuromuscular system, the daily dose is 0.05-0.1 g (15-30 drops of a 10% solution). Take for 30-60 days with repeated courses after 2-3 months. In cases of impaired spermatogenesis and potency in men, the daily dose is 0.1-0.3 g (1030 drops of a 30% solution). In combination with hormonal therapy, it is prescribed for 30 days.

If there is a threat of miscarriage, alpha-Tocopherol acetate (Vitamin E) is taken at a daily dose of 0.1-0.15 g (10-15 drops of a 30% solution) for 7-14 days. In case of abortion and deterioration of intrauterine development of the fetus, 0.1-0.15 g (10-15 drops of a 30% solution) per day is prescribed daily or every other day for the first 2-3 months of pregnancy. For atherosclerosis, myocardial dystrophy, peripheral vascular diseases, 0.1 g (30 drops of a 10% solution or 10 drops of a 30% solution) of the drug is administered together with vitamin A per day. The course of treatment is 20-40 days with possible repetition of treatment after 3-6 months.

For complex therapy of cardiovascular diseases, eye and other diseases, alpha-Tocopherol acetate (Vitamin E) is prescribed in a dose of 0.05-0.1 g (15-30 drops of 10% solution) 1-2 times a day. The course of treatment is 1-3 weeks.

For dermatological diseases, the daily dose of the drug is 0.05-0.1 g (15-30 drops of a 10% solution). The course of treatment is 20-40 days.

For malnutrition and decreased capillary resistance in infants, use a daily dose of 0.005-0.01 g (3-6 drops of a 5% solution).

For prophylactic purposes, the drug is used at 0.01 g (6 drops of a 5% solution) 1 time per day for 1-3 weeks, for children less than 0.01 g per day.

It is preferable to use the drug during meals.

Side effects

In isolated cases, allergic reactions (itching, skin flushing and rash) may occur. With long-term treatment, in rare cases, nausea, constipation, diarrhea, headache, increased fatigue, weakness, dysfunction of the gonads, thrombophlebitis, hypercholesterolemia are possible.

When using significant doses, minor temporary stomach upset, epigastric pain, headache, dizziness and blurred vision are possible. Taking large doses can aggravate bleeding disorders caused by a lack of vitamin K in the body and dysfunction of the thyroid gland. If the side effect is severe, the drug is discontinued.

Contraindications for use

Hypersensitivity to the drug, severe cardiosclerosis, myocardial infarction, bleeding disorders, hypoprothrombinemia. Take with extreme caution if there is an increased risk of thromboembolism.