Proginova: why it is prescribed, application, results, reviews. Proginova - instructions for use and composition, release form, indications and cost Proginova how to drink during pregnancy when is the best time to start
What is Prolignova
Prolignova is a hormonal drug, which contains estradiol valerate, which is a synthetic analogue of the hormone estradiol produced by the ovaries. The drug also contains estrogens.
Why is Prolignov prescribed? and when stimulating IVF drug promotes compaction of the endometrial layer of the uterus for reliable attachment of the fertilized egg. Prolignova has a positive effect on the estrogen levels of the body without affecting the production of other hormones.
The drug is prescribed in the following cases:
- if previous pregnancies did not go smoothly or were interrupted;
- in case of hormonal imbalances in preparation for pregnancy;
- if necessary, “grow” the internal tissue of the uterus (endometrium);
- if necessary, stimulate the placenta and improve its blood circulation.
The Proginov package contains 21 tablets, which are designed for 1 course of taking the drug. Must be taken at the same time, one tablet once a day. The first tablet should be taken within the first 5 days from the beginning of the menstrual cycle. If you do not have your period, you can take the first pill any day.
A medical consultation is also needed to choose drug cycle, there are two of them?
- Cyclic reception. Reception begins on the fifth day of the menstrual cycle or on any day if there is no cycle at the moment. The duration of treatment is 21 days, after which there is a week break. After this, on the eighth day, the second 21-day cycle begins.
- Continuous reception. The drug is used in two identical cycles of 21 days, but there is no seven-day break between them. In both cases, take one tablet per day.
The drug is considered effective, pregnancy often occurs after the first cycle, however, like any hormonal drug, it has its own range of side effects and contraindications. Take Proginova during pregnancy is possible only up to . If pregnancy has occurred, then it is better to gradually stop taking Proginov.
The following side effects are possible:
- problems with the stomach, intestines and other gastrointestinal organs (flatulence, diarrhea, nausea, etc.);
- sensory organ disorders (depressive states, dizziness, insomnia, etc.);
- disorders of the cardiovascular system (tachycardia, etc.);
- allergic reactions (swelling, urticaria, rash, itching, etc.);
- disorders of the reproductive system (menstrual irregularities, discomfort).
If these or other side effects of the drug are detected It is necessary to interrupt the cycle of taking it and immediately consult a doctor.
No cases of overdose have been identified.
The drug should not be taken if:
- tumor neoplasms and gastrointestinal diseases;
- bleeding of the reproductive system;
- during lactation;
- after the eighth week of pregnancy.
The simultaneous use of Proginov and other estrogen-containing drugs, including contraceptives, is prohibited.
Reviews about Proginova when planning pregnancy
Valentina
The drug Proginova was prescribed for endometrial growth. The previous pregnancy was three years ago, but it was terminated at an early stage. I'm finishing the course now. An ultrasound showed that the endometrium is normal and the likelihood of new problems is much less, I hope for the best. It’s a good remedy, but hormones are no joke – first you need to go to the doctor and get tested for hormones. The product is inexpensive, you should always take it at the same time, I took it in the morning.
My gynecologist prescribed Proginova for endometrial growth. There were problems with my first pregnancy, and I’m already 30+. In general, it’s good, the endometrium actually recovered after the first cycle. But I’ll tell you right away – my weight went up, I gained four kilos during the cycle.
Galina
I had serious problems with the endometrium - its thickness was several times less than necessary, which means pregnancy was a dangerous undertaking. The doctor prescribed it to me in the middle of my cycle. After two weeks I took two tablets in the morning and in the evening. Now there is a result, the endometrium is still smaller than normal, but has become much thicker; this has not yet brought me pregnancy.
The onset and successful course of pregnancy is an urgent problem that worries many couples at the present time. Nowadays, there are many factors that impede conception and healthy bearing of offspring: the disastrous environmental situation in cities, a small amount of vitamins and nutrients in food, and an incorrect rhythm of life. All this leads to a general deterioration in health, as well as dysfunction of the reproductive system in both women and men. But medicine does not stand still - to help women planning pregnancy, doctors prescribe modern drugs that can have a beneficial effect on the female body.
Action and composition of the drug Proginova
The hormonal drug Proginova is a synthetic analogue of the hormone estrogen. It is this hormone that is decisive in the onset and successful course of pregnancy. 
hormone therapy for women
Composition Proginova
One of the reasons for the inability to get pregnant is a hormonal imbalance in a woman’s body. In this case, doctors prescribe hormonal drugs to patients that help normalize hormonal levels. One of these auxiliary agents is the drug Proginova.
This drug contains the main component - in each tablet - 2 mg of estradiol valerate. This component does not interfere with or disrupt the natural production of hormones by the body, but actively helps it. In fact, estradiol valerate is identical to the natural hormones estrogen.
Effect of the drug
Very often, pregnancy does not occur due to the thin layer of endometrium that lines a woman’s uterine cavity. The drug Proginova promotes thickening of the endometrial layer, which subsequently has a beneficial effect on the onset and successful course of pregnancy.
Also, the hormone estrogen is able to protect the female body from various gynecological diseases.
Thus, the drug Proginova compensates for the lack of female hormones - estrogens.
Indications for use
The drug Proginova is prescribed:
- for gynecological diseases;
- in case of hormonal imbalance;
- if you are unsuccessful in trying to get pregnant;
- with repeated miscarriages.
Contraindications and side effects
Proginova is contraindicated in the following cases:
- breast diseases
- oncological diseases
- liver diseases
- myocardial infarction, stroke
- increased risk of thrombosis
- lactose intolerance
- pregnancy and breastfeeding
- age up to 18 years
- hypersensitivity to the components of the drug
Side effects are:
- changes in vaginal bleeding
- discomfort and pain in the mammary glands
- gastrointestinal problems: vomiting, nausea, bloating
- allergic skin reactions
- depression, dizziness and headaches from the nervous system
- changes in body weight, swelling, changes in libido, muscle cramps
Despite the contraindication of taking the drug during pregnancy, in practice Proginova is often used in the early or late stages of an “interesting situation.”
Dosage and duration of therapy
The course of treatment is 21 days, during which it is necessary to take one tablet of the drug per day, at approximately the same time. Then there is a 7-day break. But sometimes Proginova is taken without interruption. The duration of use of the drug is individual for all women (use for 6 months is possible). Further, at the discretion of the attending physician.
The use of Cyclo-Proginova when planning pregnancy and its difference from the drug Proginova
two-component hormonal drug The drug Cyclo-proginova is presented in the form of two types of dragees in one package (tablets of different colors): one part of the tablets (white) contains 2 mg of estradiol valerate (like the drug Proginova), the other (brown) - 2 mg of estradiol valerate and 0.15 mg norgestrel. Thus, taking Cyclo-Progynov lasts for 21 days, then you need to take a break for 1-2 weeks. The drug Proginova can be taken either cyclically or continuously (it is monocomponent). In general, the drug Cyclo-proginova has the same effect as the drug Proginova - it compensates for the lack of the hormone estrogen in a woman’s body due to estradiol. But at the same time, this drug, thanks to norgestrel, prevents the risk of cancer of the reproductive system of the body.
The main difference between these two drugs is the composition: Proginova is a monocomponent drug (promotes the production of estrogens), and Cycloproginova is a two-component drug (in addition to containing estradiol, it includes a progesterone component).
Proginova is prescribed for problems with conception due to a thin layer of endometrium in the uterine cavity. Cyclo-Proginova is recommended for use in case of problems with the menstrual cycle.
Cyclo-proginova is also prescribed when planning pregnancy, but in most cases this drug is used for ovarian dysfunction and for symptoms of menopause. It is not recommended to replace these two drugs with one another! In any case, it is necessary to consult with your doctor before starting to use each of these drugs! Based on a medical examination, the doctor will already determine which remedy will be best for you! 
When taking medications, you must follow all instructions!
Reviews
The drugs Proginova and Cyclo-proginova are prescribed to many women who have gynecological problems. In most cases, the drugs have positive reviews. Side effects from the use of these hormonal drugs are extremely rare. At the same time, Proginova and Cyclo-proginova are available in almost every pharmacy!
Normal drug. In case of premature ovarian failure, it perfectly replaces missing hormones. I took it for 4 years, stopped it, all the delights of menopause began, and went back to this drug. True, with such a long-term use, slight swelling began, and it’s not a fact that it was from the drug. I'm 38.
isida2001:
http://otzovik.com/review_4027340.html
To build up the endometrium, I tried both Divigel and Femoston, but it was Proginova that played the decisive role. During stimulation with Clostilbegit, at first I was all smeared with Divigel, the dosages prescribed were no longer comic, and the endometrium did not really grow - 5 millimeters maximum and that’s all, and the follicles were already on the way... They decided to tighten up Proginova, and by the time of ovulation the endometrium had grown to 8 millimeters. I didn't feel any side effects. The drug is available.
Ninzelya
http://otzovik.com/review_1759774.html
For many years I have suffered from a lack of hormones (((hence infertility and other problems. For the second year now I have been taking the drug PROGINOVA, which replenishes my estrogen. The positive thing is that the drug does not interfere with me: no unpleasant sensations, side effects or other inconveniences The disadvantage of this medicine is changes in weight, since in my opinion it retains water in the body, and the fact that if you drink it on an empty stomach, it causes nausea, so the advice to drink after eating (in the annotation is not prohibited in general). . Be healthy!!
http://irecommend.ru/content/pri-estrogennoi-nedostatochnosti
During planning and in the early stages of pregnancy, I had to use similar hormonal drugs. The reason for this was the risk of miscarriage. During the entire time I took the pills, I never felt any discomfort or any side effects! And from the psychological point of view, hormonal medications allow you to feel much calmer - you gain confidence in a positive outcome of pregnancy! A balanced psycho-emotional state of a woman is the key to successful conception and a happy period of bearing a baby! 
Hormonal drugs contribute to the onset and maintenance of pregnancy!
The drugs Proginova and Cyclo-proginova are auxiliary means for the production of estrogens - hormones that women need! Due to their properties, these drugs have a positive effect on the body as a whole. In addition to their main purpose, Proginova and Cyclo-Proginova also have a beneficial effect on the nervous system. Do not be afraid to take hormonal medications if the need arises. But in any case, taking these medications on your own is strictly prohibited! An examination of the body and consultation with a doctor is necessary!
Hormonal imbalances in the female body often become an insurmountable obstacle to conception. Therefore, as part of a comprehensive treatment of infertility, doctors use hormonal drugs that help normalize the disturbed concentration of hormones. When planning pregnancy, Proginova has a beneficial effect on all processes in the female reproductive organs. Taking the drug provides two important components for successful conception: endometrial growth and a sufficient amount of estrogen in the body.
The hormonal drug Proginova is monocomponent, that is, it contains one main component - estrogen. This artificial hormone in its composition and action is no different from the natural one produced by women's ovaries. When it enters the female body, the synthesized hormone is converted into estradiol.
Estrogen and estradiol are necessary for a woman at all age stages of her body’s development. These hormones regulate the consistency of the menstrual cycle, promote the proper development of the endometrium and the onset of ovulation. With their correct concentration, women are less likely to experience headaches and nervous disorders.
This is a good remedy for stimulating the ovaries. After taking it correctly, the organs begin to independently produce the necessary substances without drug intervention.
A lack of necessary hormones may be associated with diseases of the female reproductive system or during menopause. Hormonal support is also needed for those women who are in the rehabilitation stage after surgery, for example, after removal of the ovaries. However, the most common reason for treatment with Proginova is female infertility.
The instructions for use of the drug determine the use of the drug by women in the following cases:
- Lack of conception due to too thin endometrium;
- Irregular or defective ovulation;
- Failure to develop pregnancies or conceptions that end in miscarriage;
- Insufficient concentration of estradiol, due to which the follicle cannot leave the egg;
- During the preparation procedure for IVF and after it.
The ability of the drug to stimulate blood circulation in the placenta allows it to be used after conception.
The package contains 21 tablets. Take the drug daily in the dosage prescribed by the doctor. The main rule when using Proginov is to take the tablets at the same time. Therapy is started with a regular menstrual cycle on the fifth day after the start of menstruation. If the cycle is absent or irregular, treatment begins on any day convenient for the patient.
How Proginova promotes conception
When planning pregnancy, Proginova is prescribed to women who want to quickly conceive a child. The drug is particularly effective when the patient has difficulties conceiving, expressed in the following disorders:
- If the endometrium is too thin;
- In the absence of ovulation or its irregularity;
- With low concentrations of estrogen in the blood.
Proginov is prescribed according to different schemes. But they are all united by a conditional division into two groups: taking the medicine in cycles or continuously.
The cyclic dosage regimen involves using the drug for 21 days, one tablet per day (as many tablets as there are in one package). Then you need to take a break for one week. After, on the eighth day, treatment is continued for 21 days. A continuous treatment regimen involves taking the drug for 2-3 months without interruption.
How to use Proginova when planning a pregnancy is decided only by the attending physician. The drug is a potent hormonal agent, therefore its independent administration and dosage selection is unacceptable!
Most often, with a correctly calculated treatment regimen, a woman forgets about infertility after one or two courses of therapy. Conception does not occur in rare cases. The reasons for the lack of pregnancy after therapy are associated either with the fact that the medicine was prescribed incorrectly, or with the following diseases:
- Pathologies of the pelvic organs;
- Disturbances in the functioning of the endocrine system;
- Low threshold of sensitivity to the components of the drug.
The instructions for use of the drug say that the drug is prohibited during pregnancy. However, this only applies to those cases where conception occurred naturally without prior use of medications. If pregnancy occurs due to stimulation of Proginov, therapy is continued in the following cases:
- At the beginning of pregnancy, up to 8-10 weeks of embryo development, if tests have detected a reduced level of female hormones;
- Before delivery, if labor progresses poorly or the woman carries the baby longer than expected.
The decision about whether to continue treatment with Proginova during pregnancy should be made only by your obstetrician-gynecologist. It is best to ask him in advance what to do if: continue taking the pills or stop taking them.
Cyclo-Proginova for conception
In preparation for conception, doctors use several drugs that have a similar effect on the ovaries. These include Cyclo-Proginova.
Despite the similarity of names and specific action, drugs have significant differences in composition. The main active components of Cyclo-Proginov are two synthetic hormones - estradiol and progesterone. Consequently, the possibilities of the drug are somewhat wider, because its use does not require additional intake of other hormonal drugs.
When planning pregnancy, Cyclo-Proginova is taken for the same diagnoses as its brother of the same name, but the regimen for its administration will be different. After all, the content of two hormones in the drug determines the nuances of use and certain precautions.
Each package contains 21 tablets. Start taking it on the fifth day of the cycle with “estrogen” white pills. They are taken for 11 days (in the first follicular phase of the cycle), then light brown “progesterone” tablets are taken for 10 days. Then they take a seven-day break.
How Proginova is combined with Clostilbegit, Utrozhestan, Duphaston
The use of Proginov when planning pregnancy is often supplemented with other medications. This is necessary to enhance the effect of the drug or “help” other drugs achieve the desired goal, softening or intensifying their effect. Let's look at the most popular and effective interactions.
Klostilbegit
Clostilbegit is used as a strong hormonal effect on the ovaries to stimulate ovulation. Its active substance (clomiphene citrate) blocks the appearance of estrogens. The main task of the drug is to activate the production of other hormones: FSH and LH. They are responsible for the onset of full ovulation.
Despite the effectiveness of the drug, it can cause a dangerous side effect in the form of ovarian enlargement. The organs acquire very large sizes, reaching 5-20 cm. Women who experience hyperstimulation feel a general deterioration in well-being, which manifests itself as intoxication of the body. Often, patients can only be helped in this case in an inpatient setting.
When Clostilbegit and Proginova are used together, such side effects are not observed. Proginova replenishes the estrogens “destroyed” by Clostilbegit, normalizing hormonal levels, so the woman does not feel dangerous symptoms.
Like other hormonal therapy, treatment is carried out under the supervision of a doctor who monitors changes in the patient’s condition using ultrasound.
The scheme and Proginova are regulated individually. However, most often the drugs are taken using this method.
Starting from days 5-8 of the cycle, the patient is advised to take Clostilbegit. After starting therapy, the doctor begins to monitor the condition of the ovaries, waiting for the follicles to grow to the desired size. After this, the woman is given an injection of hCG, which “causes” the mature follicles to burst so that a corpus luteum is formed in their place.
After the doctor is convinced that ovulation has occurred, they begin taking Proginov, which replenishes the missing estrogen.
Utrozhestan
Considering that the medicine contains only one hormone, Proginova is often combined with drugs containing progesterone when planning pregnancy. Taking them simultaneously allows you to complement each other's action.
Thus, Proginova allows us to provide the necessary conditions for full conception: estrogen prepares the endometrium, and progesterone “allows” the fetus to securely anchor itself in the walls of the uterus.
Duphaston
When planning a pregnancy, Proginova act as allies, reinforcing and complementing each other’s actions.
By taking them together, two important goals are achieved at once: they normalize the thickness of the endometrium and the concentration of necessary hormones.
Proginova with IVF
Proginova in IVF is used for the same purposes as for natural conception. Moreover, the presence of the drug in the cryoprotocol is justified at all stages of in vitro fertilization.
Proginova before IVF is needed to normalize the thinned endometrium. The medication is taken according to an individual regimen for at least 3 weeks. The effectiveness of therapy is monitored by a doctor using ultrasound diagnostics so that the dosage of the drug can be adjusted if necessary.
Before cryotransfer, the drug is not stopped to maintain stabilized hormonal levels. For the same reason, after embryo transfer, Proginova should be administered to the body in an individual dosage. At this time, the correct concentration of hormones is extremely important for the fetus attached to the uterus.
During pregnancy after IVF, the drug is used to maximally protect the fetus from hormonal imbalance. It is drunk until 10 weeks after conception so that estrogen levels remain normal. Then begin a gradual reduction in dosage so that by 15 weeks the drug is stopped.
Contraindications and side effects
Proginova is a potent drug containing a synthetic hormone. Therefore, its use must be justified. Before the appointment, the doctor will order the woman to undergo the following examinations to reduce the risk of side effects:
- Blood and urine tests;
- Gynecological examination;
- Study of hormonal levels;
- Mammography.
The presence or absence of chronic diseases, their stage and characteristics of the course are clarified. The drug is prohibited for use by women in whom diagnostics has revealed the following abnormalities:
- Individual sensitivity to the active component of the drug;
- Bleeding;
- Suspicion of a malignant breast tumor;
- Acute thrombosis;
- Lactation period;
- Pathologies of the liver and biliary tract;
- Pancreatitis;
- Anemia;
- Fat metabolism disorders;
- Children under 18 years of age.
Special precautions are required when prescribing the drug for the following pathologies:
- Diabetes;
- Mastopathy;
- Migraine;
- Hypertension;
- Uterine fibroids;
- Epilepsy.
Despite the fact that, compared to other hormonal drugs, Proginova has a gentle effect on the body, there is still a risk of developing side effects.
These include the following manifestations of the body:
- Increased heart rate;
- Abnormal bowel movements such as constipation or diarrhea, abdominal pain;
- Depression;
- Decreased sexual desire;
- Visual impairment;
- Allergic reaction;
- Changes in body weight (loss or gain);
- The appearance of excessive hair growth;
- Breast enlargement and tenderness;
- Uterine bleeding.
If these symptoms appear, you should consult a gynecologist who will prescribe a drug withdrawal regimen.
Immediate medical assistance is necessary if the following symptoms develop while taking the drug:
- Fainting;
- Cough with bloody sputum;
- Jaundice;
- Speech and vision disorders;
- Swelling and pain in the legs;
- Suffocation.
In this case, taking the drug must be stopped. But this does not mean that hormone replacement therapy is not suitable for you; you can choose other pills. Your doctor will prescribe them.
The drug Proginova is a hormonal drug that contains synthetic estrogens. They are absolutely similar to natural estradiol produced by the ovaries. If there is a lack of this hormone, a woman experiences difficulty conceiving and subsequently bearing a child. The use of Proginov at the pregnancy planning stage helps to improve the reproductive function of the expectant mother.
Read in this article
Why is Proginov prescribed?
More and more couples are starting to worry about expanding their family in advance. The planning process includes not only taking vitamins and establishing a healthy lifestyle, but also screening for various disorders and diseases.
If, after the test results, it turns out that a woman has a lack of estrogen, the doctor often prescribes her the drug Proginova.
When planning
A woman may face the following violations:
- absence or irregular ovulation;
- too thin layer of endometrium in the uterus;
- already former;
- weak labor activity;
- polycystic ovary syndrome and hirsutism;
- primary and secondary amenorrhea;
- weak menstruation, which is a sign of insufficient or declining ovarian function.
The use of the drug helps to cope with the above pathologies, and also makes it possible to conceive in the first cycles.
With IVF
Proginov is also prescribed in preparation for the use of reproductive technologies.
Often, a woman cannot conceive because the endometrium, the layer that covers the uterine cavity, is not adequate. It is where the fertilized egg is implanted. Before ovulation begins, it should be at least 7 mm, but in some women it barely reaches only 4 – 5 mm. So the fertilized egg is not able to stay inside the uterus, which means the pregnancy will not continue.
During IVF, Proginov is prescribed precisely to stimulate the formation of the required thickness of the endometrium. This increases the chance of a successful attempt at fertilization and pregnancy. Also, after the procedure, Proginova is prescribed as hormonal support so that the implanted egg can “take root.”
IVF procedure The main difference of this drug is its mild and gentle effect on the female body. With its help, the work of the ovaries is suppressed, it artificially ensures a stable hormonal background. Once estrogen levels are normalized, all complications caused by estrogen imbalance are eliminated.
The effect of the drug on the female body
Proginov’s main task is to stabilize hormones, which is manifested by the following effects on the body:
- stable estrogen levels regardless of unfavorable conditions such as stress, colds, chronic illnesses;
- prevention ;
- prevention of miscarriages;
- normalization of blood supply to the placenta.
It helps protect the woman’s body, preserve pregnancy and the life of the embryo. The drug contains an estrogen component and estradiol valerate. They maintain optimal levels of hormones in the female body, which improve ovarian function. As soon as the drug is stopped, the woman begins to ovulate stable. It also helps cope with stress and emotional changes.
It is important to note that while taking Proginov, your own ovulation does not stop, and the production of natural hormones also continues.
Regular use of the drug improves the condition of the mucous membranes and skin, accelerates tissue regeneration. As a result, the epidermis becomes firmer, more elastic, wrinkles are reduced, and the amount of collagen increases. A woman’s sleep and mood also improves.
Contraindications
Despite all the benefits, you should not take this drug on your own. Only the attending physician can prescribe it.
- In addition, Proginov has a number of contraindications. The drug should not be taken if:
- the presence of diabetes of varying degrees;
- cardiovascular diseases;
- thrombophlebitis, thrombosis and the active phase of thromboembolic pathology;
- diseases of the gallbladder and liver;
- benign formations;
- being a minor;
- breastfeeding period;
bleeding in the uterus of unknown cause.
Proginova is also not taken in parallel with other hormonal drugs, especially those containing estradiol. An excess of estrogen in the body is fraught with nausea, migraines, vomiting, dizziness and weakness.
Watch the video about what hormones affect the ability to get pregnant:
Features of reception and scheme
As a rule, the use of Proginov ends successfully. Doctors often prescribe it to their patients. The package contains 21 capsules, which you need to drink 1 capsule per day.
It is possible to take Proginova according to two schemes. The first time you need to take the pill is on the fifth day of the cycle, and if it is not there, then when it is convenient. According to the cyclic regimen of taking Proginov, you need to drink capsules for exactly 21 days, after which you should take a break for a week. Then on the eighth day a new cycle of taking the drug begins.
According to the scheme of continuous use of the product, you need to drink it for 21 days and immediately after finishing the package, start a new course without taking a break.
The attending physician decides which type of treatment is best. In addition, Proginova is available in other forms: spray, gel, solution for intramuscular administration.
There is also a combined dosage regimen. It consists of simultaneous use of the drug with a gestagen. You need to take both drugs for two weeks, then take a break for a month.
It is important not to miss taking Proginov and not to make mistakes, otherwise there may be bleeding. When pregnancy occurs, the course continues for another two months.
When is Cyclo-Proginova prescribed, and when is Proginova prescribed? Both drugs are similar in that they contain hormones.However, Proginova contains only estradiol, and Cyclo-.
Proginova also contains norgestrel
Cyclo-Proginova and Proginova compensate for the lack of estrogen in a woman’s body. They contribute to the formation of the endometrium in the uterine cavity of the required thickness, which allows the embryo to consolidate and begin to develop.
Both drugs have a similar composition and purpose, but it is not recommended to replace one with the other. Cyclo-Proginova can be prescribed in a cyclic dosage regimen.
Why pregnancy may not occur after the course
Sometimes, despite taking the drug conscientiously, pregnancy does not occur. In such cases, it may be caused by factors such as:
- non-acceptance by the female body of the components of the product as a medicine;
- the presence of other serious gynecological and endocrine diseases.
In both cases, during preparation for pregnancy, the drug will be least effective. Therefore, a better and more detailed examination and the use of a remedy to which a woman will be more susceptible is necessary.
Possible side effects
Proginova, like any hormone-based drug, can cause a number of specific side effects. These include:
- nagging pain in the lower abdomen;
- bloating, feeling of heaviness;
- colic in the intestines;
- decreased sexual desire;
- anomeria (absence of menstruation for more than six months);
- increased sensitivity in the chest;
- fast fatiguability;
- the appearance of rash and irritation;
- tachycardia;
- pressure changes;
- apathy and indifference;
- migraine;
- formations in the mammary glands;
- weight gain;
- increased sensitivity to wearing contact lenses.
It is very important to monitor your condition if one or more side effects occur. If it worsens or intensifies, the doctor should discontinue Proginov and begin treatment for the resulting symptoms.
When to stop the drug
As follows from the above, there are situations when, due to the patient’s health conditions, it is necessary to discontinue the drug.
- This should be done immediately in situations such as:
- severe headache or migraine, even if it occurs for the first time;
- sudden deterioration in hearing or vision;
- the appearance of a yellow tint on the skin;
- spotting that does not correspond to the cycle;
- swelling in the arms and legs;
breathing complications with cough and bloody discharge, possible thrombosis. Women with vascular problems should take Proginova with extreme caution.
During pregnancy planning, Proginova restores the lack of estrogen in the female body, which has a positive effect on reproductive function.
This increases the couple's chances of conceiving a healthy baby. However, self-administration of the drug is prohibited. Only the attending specialist can prescribe it, and he must constantly monitor the patient’s condition.
A woman’s ability to conceive a baby depends on many factors - immune function, lifestyle, reserves of vitamins and minerals, and negative external influences. Sometimes a woman has to go through a difficult path before she becomes a mother, which involves taking special hormonal medications. One such remedy is Proginova. How does the drug affect the process of conception, does it have contraindications and what is the regimen for taking it?
Proginova is a synthetic hormone of the sex glands, designed to replenish estrogen, which is not produced by the ovaries. Once in the blood, the drug quickly balances hormonal levels and eliminates disorders that arise as a result of hormonal dysfunction. This pathology is manifested by menstrual dysfunction, nervous disorders, and infertility.
Proginova is a monocomponent medicine containing only one active component - estradiol valerate. The drug is produced in small tablets containing 2 ml of estradiol in each pill. The dragees are packed in blisters of 21 pieces.
Important! The drug Cyclo-Proginova is on the market. It has a completely different composition, represented by estradiol and gestagen. And although he and Proginova have similar indications, the reasons for his appointment are different.
Estradiol contained in Proginov is a synthetic substance, but by its nature it is no different from human estradiol and is well accepted by the body. Taking capsules allows you to completely eliminate the signs of estrogen deficiency during menopause or during pathological hormonal fluctuations.
Estradiol valerate breaks down into estradiol and valeric acid. At the same time, only 3% of the released estradiol becomes bioavailable and is fully absorbed by the body.
With regular use of Proginova, the level of estradiol stabilizes and becomes twice as high as with a single dose of the tablet. Three days after stopping the drug, estrogen levels drop to the original level.
Important! Estrogen deficiency provokes infertility and miscarriage. Fortunately, hormone replacement therapy allows pregnancy to occur after Proginova.
Proginov tablets are prescribed to correct hormonal levels that are disrupted as a result of estrogen deficiency. When the ovaries stop synthesizing estrogens in the required quantity, a woman experiences various pathologies, in particular:
- Problems with the psycho-emotional background, for example, insomnia, memory impairment, fatigue, neuroses.
- Violation of thermoregulation (chilliness, sweating).
- Cardiovascular abnormalities (arrhythmia, headaches, angina attacks).
- Urogenital dysfunction (vaginal dryness, problems with urinary incontinence, decreased libido).
- Diseases of the reproductive system (infertility, problems with menstruation).
- Diseases of the musculoskeletal system (joint pain, osteoporosis, gout).
- Postmenopausal clinic.
- Neoplasms of various etiologies in the mammary glands, ovaries, and uterus.
- Hirsutism.
- The problem of miscarriage.
It is these diseases and symptoms that serve as the reason for prescribing Proginova when planning pregnancy, especially if a woman has problems conceiving. Proginova is also prescribed during IVF for the purpose of growing the endometrium for better embryo transfer.
The drug actively affects the general health of a woman. Treatment can eliminate hot flashes, dry skin, irritability, infertility, depression and other symptoms of estrogen deficiency. However, doctors prescribe Proginova only in cases where estrogen deficiency is more dangerous than oral administration of the hormonal drug.
When is Proginova contraindicated?
Proginova has several contraindications that are important to consider when prescribing this drug to women. Self-medication is unacceptable, since ill-informed medication use can lead to serious complications.
When taking Proginova tablets is unacceptable:
- Breastfeeding period.
- Estrogen intolerance.
- Genital bleeding of unknown origin.
- Hormone-dependent malignant tumors (neoplasms in the mammary glands, ovaries, liver, endometrium).
- Predisposition to thrombosis.
- Varicose veins
- Liver damage.
- Endometrial hyperplasia.
- Age under 18 years.
- Lactose intolerance.
- Lipid metabolism disorders.
The manufacturer also notes that Proginova should be prescribed with extreme caution if a woman has the following diseases:
- Arterial hypertension.
- Gallstone pathology.
- Epilepsy.
- Endometriosis.
- Uterine fibroids.
- Thromboembolism.
- Systemic lupus erythematosus.
- Diabetes.
- Gilbert and Rotor syndromes.
- Migraine
- Asthma.
- Severe obesity.
- Hereditary angioedema.
- Prolactinoma.
Important! According to the instructions, taking Proginov during pregnancy is contraindicated, but in exceptional cases it can be prescribed to pregnant women.
Proginova: instructions for use
Proginova is a systemic hormonal drug that affects most systems of the female body, and therefore can only be taken according to the regimen prescribed by the doctor.
Important! If a woman is undergoing long-term replacement therapy with Proginova, she is advised to undergo regular mammography, since taking the drug can provoke the growth of tumors in the mammary glands.
Proginova when planning pregnancy: dosage regimen
The drug is prescribed when planning a baby for various reasons. This may include clinically confirmed estradiol deficiency, insufficient growth of the endometrial layer, and the risk of early pregnancy termination. Proginova is also often included in the IVF procedure, since it allows you to “grow” a full-fledged endometrium for embryo transfer.
Before starting treatment, the doctor must weigh the risks of taking Progynova and the possible benefits of hormone replacement therapy. Treatment may be justified only when alternative treatment options do not restore the woman's reproductive function. After a thorough examination of the woman, the doctor draws up an individual treatment strategy.
The Proginova treatment regimen requires strict implementation, so even minor violations are not allowed. You should pay close attention to the treatment and always take the prescribed dose of medication on time, without missing a single dose. This is a very important point, since a missed pill can cause a sharp fluctuation in estrogen levels, and the entire menstrual cycle will be disrupted.
Proginov's dragees are taken whole, without violating the integrity of the shell. It is advisable to take the drug with clean water. The next dose should be taken at the same time of day, regardless of food intake.
If it happens that the pill was not taken, you need to drink it within 24 hours. If there was no opportunity to take the medicine, the missed tablet is thrown away, and the next day, taking Proginova is resumed (the next tablet in sequence is taken). If one or more doses are missed, there is a risk of bleeding and even breakthrough bleeding.
Advice! For convenience, you need to choose a suitable time when you can take the pill without problems, for example, immediately after breakfast, and set a reminder on your gadget.
Depending on the state of the woman’s reproductive system, treatment with Proginova can be carried out according to the following schemes:
- Combined: a woman is prescribed Proginova and Duphaston at the same time when planning a pregnancy. The first drug is prescribed for 21 days every month with an 8-day break. Duphaston can be prescribed for 10-14 days or for a month. This regimen allows you to correct the menstrual cycle and infertility caused by estrogen deficiency. Separate administration is also carried out: from 10 to 14 days of the cycle Proginova is taken, and from 16 to 26 - gestagen.
- Cyclic: Proginova is prescribed for 21 days without additional administration of gestagen. Take 1 capsule per day, then discontinue the drug for a week and resume taking the hormone on the 8th day.
- Constant: treatment involves continuous use of the drug without a week's break.
When planning a child, start taking Proginova from days 1 to 5 of the cycle. As a rule, in women without hidden diseases of the endometrium and endocrine system, pregnancy occurs within 1-3 courses of treatment. After conception, taking the drug is not recommended, but in some cases it is possible to take Proginov during early pregnancy in order to prevent miscarriage.
Proginova during pregnancy after IVF
In order for fertilization to be successful, Proginova is prescribed to balance hormonal levels. Reception begins at the time of ovarian stimulation and continues in the early stages of gestation if the embryo transfer was successful.
It is worth noting that not every woman needs to take Proginova during the IVF process. Treatment is carried out only if there are hormonal disorders or if the woman does not have ovaries.
Proginova: until what week of pregnancy should I take it?
Taking the drug can last up to 8-10 weeks of gestation, while estradiol is responsible for maintaining pregnancy. After 10 weeks, taking Proginova becomes unnecessary, since the placenta begins to function, and another hormone, progesterone, comes to the fore.
Proginova: how to cancel during pregnancy
The drug is discontinued gradually after 9-10 weeks of gestation, when the baby no longer depends on the functioning of the ovaries. However, taking Proginova should be completely stopped by the beginning of the 15th week to avoid hormonal disturbances in the fetus, especially if it is male.
The Proginov withdrawal regimen during pregnancy is selected taking into account the response of the female body. The dose of the drug is reduced by half, a third or a quarter every 3-5 days.
You need to start withdrawal with a minimal dose reduction and gradually increase it to one tablet. It is not recommended to abruptly discontinue Proginova during pregnancy, so as not to provoke termination of pregnancy.
Proginova: special instructions for women
- Before starting to take Progynova, a woman must undergo examination to determine chronic diseases. She diagnoses the pelvic organs and mammary glands, and also collects family history and all the patient’s complaints about her health. Blood pressure must be measured, a full blood pressure test, a full blood test, and an x-ray of the lungs are performed. The level of estradiol, progesterone and prolactin in the blood is also determined.
- During the treatment period, the woman’s performance does not decrease, there are no problems with controlling mechanisms, so she can continue to work fully.
- Women with fibroids, myomas or ovarian cysts may experience intensive growth of tumors while taking Progynova. In this case, treatment must be stopped.
- Taking Progynova may impair glucose tolerance, so you should check your blood sugar levels more carefully if you have diabetes.
- Before taking the drug, a woman needs to undergo a pregnancy test, since it is prohibited to start taking Progynova during pregnancy without confirmed estrogen deficiency.
- Long-term use of Proginova is often accompanied by deterioration of liver function. To prevent drug-induced hepatitis, liver function levels are regularly checked.
- While taking Proginova, the condition of the biliary tract is monitored for the formation of stones.
- Estradiol contained in Proginov tablets stimulates more intense production of thyroid hormones. If a woman has hyperfunction of this organ, she needs to examine the thyroid hormonal panel once every 1-2 months.
Gestagens and Proginova when planning pregnancy
When planning a pregnancy, a woman may be prescribed a combination of estrogens and gestagens. Proginova is taken together with Duphaston or Utrozhestan. This treatment regimen allows you to “grow” the endometrium, and then help the fertilized egg to securely gain a foothold in it.
The drugs are taken according to a combined regimen. If the need arises, continue taking Proginova and Utrozhestan when pregnancy occurs. In this case, Proginova is canceled at 8 weeks, and gestagen - after 14-16 weeks of gestation.
When is it necessary to cancel Proginova?
- Initial attack of severe migraine or its exacerbation.
- Jaundice.
- Pain behind the sternum.
- Problems with hearing or vision.
- Uterine bleeding.
- Phlebitis.
- Pregnancy.
A woman with signs of thrombosis needs emergency medical care:
- Hemoptysis.
- Fainting.
- Severe dizziness.
- Acute lack of air.
- Unbearable headache.
The appearance of one or more of the above symptoms is a reason to immediately consult a doctor.
Proginova: overdose and side effects
Taking Proginova may be accompanied by the appearance of negative reactions of the body, namely:
- dizziness;
- sudden migraine;
- changes in libido;
- decreased vision;
- dyspeptic symptoms;
- abdominal pain;
- frequent nausea;
- diarrhea, bloating;
- skin rashes;
- hirsutism or baldness;
- acne;
- convulsions;
- uterine bleeding;
- changes in the mammary glands;
- swelling of the limbs;
- hypertension;
- obesity;
- thrush;
- cerebrovascular accident;
- bleeding from the nose.
If you accidentally take too many Proginova tablets, signs of overdose occur - sudden bleeding, uncontrollable vomiting, a feeling of shortness of breath. To improve your well-being, the doctor will prescribe symptomatic treatment.
Proginova when planning pregnancy - reviews
Many ladies know firsthand about the drug Proginova. Those facing infertility or IVF had to take these pills to balance their hormone levels, without which conception does not occur.
Based on the information on the Internet, we can say that Proginova really helps women get pregnant. For some, treatment takes from 3 to 6 months, while for others only one cycle. The result largely depends on the root cause of problems with conception or miscarriage.
Especially often there are women's reviews that talk about how pregnancy occurred immediately after the withdrawal of Proginov. And sometimes women complain about the ineffectiveness of treatment and terrible side effects such as nausea and headaches.
There are cases when women undergo treatment after conception. During pregnancy, Proginova is prescribed to improve blood circulation in the uterus and prevent embryo rejection. If you believe the responses, treatment often allows you to save the child.
Video: Proginova when planning pregnancy
Proginova is a good assistant when planning a baby if a woman has problems with the synthesis of natural estradiol. Just remember that the drug requires careful and well-designed treatment.
