Yox throat medicine. Release form, composition and packaging

Yox is classified as a combination drug that has an antiseptic effect.

Thanks to the main component, iodine, the drug is able to have a bactericidal effect on pathogenic microflora and stimulate the activity of the body's defense mechanisms. The medicine also has a mucolytic effect. The drug is able to reach the deepest layers of the epidermis of the mucous membrane of the respiratory system.

In this article we will look at why doctors prescribe the drug Yox, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Yox, leave your feedback in the comments.

Composition and release form

Clinical and pharmacological group: a drug with antimicrobial and anti-inflammatory effects for local use in ENT practice.

Aerosol for irrigation 30 or 45 ml in a bottle complete with a spray nozzle and a safety cap in a cardboard package.
Solution for external use, 50 or 100 ml in dark glass bottles in cardboard packaging.

The composition of 1 ml of aerosol for irrigation and 1 ml of solution for external use includes active substances: Povidone-iodine - 85 mg, Allantoin - 1 mg.

What is Yox used for?

The drug has found wide use in the following cases:

for acute and chronic tonsillitis;
in the presence of the first symptoms of a flu-like condition;
as a means for treating the oropharynx and nose during surgical interventions in this area and in the period after surgery;
to eliminate throat and nose infections after a course of chemotherapy.
for symptoms of tonsillitis of various forms (inflammation of lacunae and follicles), as a complement to treatment of the disease with antibacterial agents;
for other infectious-inflammatory diseases in the oropharynx and nose, such as glossitis, aphthous lesions, stomatitis.

Pharmacological action

According to the instructions, Yox is a combination drug that contains polyvidone-iodine and allantoin. Thanks to these active substances, the product has a moderate immunostimulating, mucolytic and bactericidal effect.

Allantoin, which is part of the drug, has an anti-inflammatory and reparative effect, softens mucous membranes, promotes cell restoration and relieves irritation.

According to the instructions, Yox is active against Staphylococcus epidermidis, Staphylococcus aureus, group D streptococci, streptococcus pyogenes, Proteus, Neisseria, Saccharomycetes, diploid fungus, enterobacteria and the causative agent of toxic infections.

Instructions for use

Before use, remove the protective cap and install the applicator. Press the applicator 2-3 times so that the solution enters the sprayer and sprays after pressing. After this, place the applicator tube 2-3 cm into the oral cavity, hold your breath and press the cap 2 times so that one irrigation is done to the right, and the second to the left. The applicator is washed with hot water before and after use.

The drug is used 2-4 times a day, one injection to the right and left into the oral cavity and pharynx. If necessary, the drug can be used more frequently, every 4 hours.

Before use, the solution is diluted with water in a ratio of 1:20-1:40 and rinsed the mouth or throat 2-4 times a day.

Contraindications

You should not use Yox in the following cases:

hypersensitivity to iodine and other components of the drug;
pregnancy and lactation;
children under 8 years old;
dysfunction of the thyroid gland (hyperthyroidism);
heart failure;
Dühring's dermatitis herpetiformis;
simultaneous use of radioactive iodine.

Pregnancy and lactation

Contraindicated for use during pregnancy and lactation (breastfeeding).

Side effects

The drug is well tolerated by patients, but in rare cases the following side effects may develop:

allergic reactions (including itching, hyperemia, urticaria);
burning sensation at the application site;
feeling of dry mucous membranes.

If side effects occur, it is recommended to stop taking the drug. Long-term use of the drug can cause the development of iodism, a condition characterized by increased salivation, swelling of the eyelids and larynx, and the presence of a metallic taste.

Overdose

When applied topically, an overdose is impossible, but if the solution is swallowed, symptoms of acute iodine poisoning are observed.

Patients complain of a metallic taste, vomiting, nausea, stomach pain and diarrhea. Within 3 days after ingestion of the drug, anuria, swelling of the glottis up to asphyxia, aspiration pneumonia or pulmonary edema are observed. In some cases, circulatory problems were also observed.

In case of poisoning, symptomatic therapy is indicated. It is recommended to drink milk or brewed starch. If there is no damage to the esophagus, gastric lavage followed by administration of enterosorbent is indicated. There is no specific antidote.

Analogs

The drug Yox has no structural analogues for the active substance. Analogs for therapeutic effect (medicines for the treatment of glossitis):

Hexoral;
Dr. Theiss Sage;
Imudon;
Stopangin;
Tantum Verde;
Fervex for sore throat.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of YOX, spray in pharmacies (Moscow) is 220 rubles.

Storage conditions

At temperatures from 10 °C to 25 °C in a place protected from light. Keep out of the reach of children. Shelf life: 5 years. Do not use after the expiration date indicated on the package!

Conditions for dispensing from pharmacies

The drug is approved for use as an over-the-counter product.

Trade name of the drug: JOX ®

International nonproprietary name or generic name:
Povidone-iodine + Allantoin&

Dosage form:

topical spray

Compound

Active substances:
Povidone-iodine 2.550 g and allantoin 0.030 g per 30 ml.

Excipients:
levomenthol, citric acid monohydrate, sodium citrate dihydrate, ethanol 96%, propylene glycol, purified water.

Description
Transparent or slightly opalescent liquid of red-brown color, indefinitely miscible with water.

Pharmacotherapeutic group:

antiseptic

ATX code: A01AD; R02AA15

Pharmacological properties
Combined preparation for local use for diseases of the oral cavity and ENT organs. Upon contact with skin or mucous membranes, it releases iodine; has an antiseptic and anti-inflammatory effect.
The drug has a wide spectrum of antimicrobial action.
Active against bacteria, fungi, viruses, protozoa.

Indications for use
1. Infectious and inflammatory diseases of the oral cavity and pharynx: including tonsillitis, tonsillitis, tonsillopharyngitis, glossitis, stomatitis, aphthae;
2. For treatment of the oral cavity and pharynx during surgical interventions on the respiratory tract and oral cavity and in the postoperative period;
3. For the treatment of infections of the mouth and throat that occur during chemotherapy;
4. For streptococcal sore throats, it is used as an additional remedy in antibiotic treatment.

Contraindications.
- hypersensitivity to iodine and other components of the drug;
- pregnancy and lactation;
- children under 8 years old;
- dysfunction of the thyroid gland (hyperthyroidism);
- heart failure;
- Dühring's dermatitis herpetiformis;
- simultaneous use of radioactive iodine.

Directions for use and doses
Locally.
Remove the protective cap and install the applicator. Press the applicator 2-3 times so that the solution enters the sprayer and sprays after pressing. After this, place the applicator tube 2 - 3 cm into the oral cavity, hold your breath and press the cap twice so that one irrigation is carried out to the right, and the second to the left. It is recommended to use Yox ® spray 2-4 times a day. If necessary, the drug can be used more often, every 4 hours. The applicator is washed with hot water before and after use.

Side effect
Yox ® spray is usually well tolerated.
In some cases, hypersensitivity reactions to the drug and an allergic reaction to iodine (itching, hyperemia) are possible, which requires discontinuation of the drug. Long-term use of the drug can cause the phenomenon of iodism (including: metallic taste, increased salivation, swelling of the eyes or larynx), if this occurs, you should stop using the drug and consult a doctor.

Interaction with other drugs
The simultaneous use of Yox ® with other antiseptics intended for topical use in the oral cavity is not recommended. and throats, especially those containing hydrogen peroxide, due to inactivation of the drug.

Special instructions
Not intended for oral administration.
The drug should not be inhaled or swallowed.

Release form
Spray for topical use.
30 ml in bottles made of PE (polyethylene) or PET (polyethylene terephthalate), equipped with a mechanical sprayer and a lid to protect the sprayer. Each bottle, complete with an applicator or an applicator with a rotary lever, is placed in a cardboard box with instructions for use.

Storage conditions
At temperatures from 10 °C to 25 °C in a place protected from light. Keep out of the reach of children.

Best before date
4 years.
Do not use after the expiration date indicated on the package!

Vacation conditions
Over the counter.

Manufacturer
Ivex Pharmaceuticals s.r.o., Czech Republic Ostravska 29, 74770 Opava-Komarov
IVAX Pharmaceuticals s.r.o., Ostravska 29, 74770 Opava-Komarov, Czech Republic

Address for receiving complaints.
119049, Moscow, st. Shabolovka, 10, building 2, Business center "Concord"

(0.5 g), sodium citrate dihydrate (0.1 g), as well as 10 g of 96 percent ethanol, 15 g of propylene glycol and 50 g of purified water.

In 30 ml spray contains 2.55 g povidone-iodine and 0.03 g allantoin . Components such as citric acid monohydrate, levomenthol, sodium citrate dihydrate, 96% ethanol, propylene glycol and purified water were also used as excipients.

Release form

Solution red-brown in color (volume 50/100 ml) is available in bottles made of dark glass with propylene caps, one in a cardboard box. To protect the integrity of the packaging, a tamper-evident control is provided, and a measuring cap is provided for ease of use.

Spray(volume - 30 ml) is available in bottles made of polyethylene terephthalate, they are equipped with mechanical sprayers and have lids to protect the sprayer. The drug is packaged in a cardboard box and equipped with an applicator with a rotary lever.

Pharmacological action

Possesses antiseptic And anti-inflammatory effect .

Pharmacodynamics and pharmacokinetics

Povidone-Iodine is a disinfectant that is a complex of iodine with polyvidone, a high-molecular compound that can reduce toxic effects on the cells of the body. It is characterized by a wide spectrum of antimicrobial action due to its direct effect on the proteins of microorganisms ( proteolytic properties ). Has a partially bactericidal effect on gram-positive And gram-negative coca And bacilli , as well as individual anaerobic bacteria, yeast , in addition - on simple viruses .

Allantoin capable of exerting an anti-inflammatory effect, which in combination with polyvidone gives a therapeutic effect.

The drug easily penetrates the layers of the mucous membrane of the respiratory tract, giving a quick effect in acute and chronic diseases.

Iodine in the body it is converted into iodides, which are mainly accumulated in the thyroid gland. They are excreted primarily by the kidneys and in small quantities through feces, sweating and salivation.

Indications for use

infectious and inflammatory processes in the oral cavity and pharynx, including tonsilopharyngitis , And aphthous stomatitisT ;
treatment of the oral cavity and pharynx during surgery on the airways and oral cavity, as well as in the postoperative period;
first symptoms;
treatment of various infections of the mouth and throat resulting from;
streptococcal sore throat (in combination with ).

Contraindications

dysfunction of the thyroid gland, for example;
decompensated heart failure ;
Dühring (herpetiform lesions);
simultaneous use radioactive iodine , the interval before treatment with Yox is at least 2 weeks;
age up to 6 years;
pregnancy or lactation ( );
hypersensitivity to the components of the drug Yox.

Side effects

Possible with established hypersensitivity to any of the components of the drug Yox, which manifests itself in the form of dry mouth and hyperemia , occurs extremely rarely. In case of these reactions, discontinuation of the drug is recommended.

Long-term use may lead to the phenomenon iodism and the occurrence of a metallic taste, increased salivation, swelling of the eyelids and larynx.

Instructions for use of Yox (Method and dosage)

Both the solution and the spray are used topically. It is recommended to dilute the solution with water in a ratio of 1 to 20–1 to 40, that is, 2.5 ml or 5 ml (measured with the measuring cap included in the package of the drug), or 0.5–1 teaspoon. spoons in 100 ml of water. The resulting solution should be rinsed in the mouth and pharynx 2-4 times a day; if necessary, more frequent use is permissible - up to 6 times a day with a minimum interval between rinses of 4 hours.

Instructions for using Yox spray boil down to the following algorithm:

rinse the applicator with hot water;
remove the cap, install the applicator, press the applicator several times so that the solution enters the sprayer and can spray after subsequent presses;
then place the applicator tube into the oral cavity approximately 2–3 cm deep;
holding your breath, press the irrigation cap twice, the first time on the right side, the second time on the left side of the mouth.

The spray is usually used 2-4 times a day. For more frequent use, the interval should be at least 4 hours.

The duration of treatment should be determined by the attending physician depending on the nature of the disease.

Overdose

There is no information about overdose with topical use.

Interaction

Not suitable for use with antiseptics containing, since there is a high probability of inactivation of active substances.

Simultaneous use with lithium causes additional hypothyroid effect .

In this article you can read the instructions for use of the drug Yox. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Yox in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Yox analogues in the presence of existing structural analogues. Use for the treatment of sore throat, tonsillitis, pharyngitis and other infectious and inflammatory diseases of the oral cavity, throat and pharynx in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Yox- a drug with antimicrobial and anti-inflammatory effects for topical use in diseases of the oral cavity and in ENT practice. Releases iodine upon contact with skin. Has an antiseptic and anti-inflammatory effect. Has a wide spectrum of antimicrobial action. Active against bacteria, viruses, fungi, protozoa.

Compound

Povidone iodine + Allantoin + excipients.

Pharmacokinetics

Data on the pharmacokinetics of the drug Yox are not provided.

Indications

infectious and inflammatory diseases of the oral cavity and pharynx, incl. tonsillitis, tonsillitis, tonsillopharyngitis, glossitis, stomatitis, aphthae;
chronic pharyngitis and tonsillitis;
for treatment of the oral cavity and pharynx during surgical interventions on the respiratory tract and oral cavity and in the postoperative period;
for the treatment of infections of the mouth and throat that occur during chemotherapy;
for streptococcal sore throats, it is used as an additional remedy in antibiotic treatment.

Release forms

Solution for topical use.

Topical spray (sometimes mistakenly called an aerosol).

Instructions for use and method of use

Solution

The drug is used to rinse the mouth and throat 2-4 times a day. If necessary, the drug can be used more often - up to 6 times a day. The minimum intervals between rinses are 4 hours.

Before use, dilute the drug solution with water in a ratio of 1:20-1:40 (i.e. from 2.5 ml to 5 ml using the measuring cap included in the package or 1/2-1 teaspoon in 100 ml of water). Rinse the mouth and throat with a diluted solution.

Spray

The drug is used 2-4 times a day, one injection to the right and left into the oral cavity and pharynx. If necessary, the drug can be used more frequently, every 4 hours.

Side effect

hypersensitivity reactions to the drug;
local manifestations of an allergic reaction to iodine (itching, hyperemia), which may require discontinuation of the drug;
with prolonged use, phenomena of iodism are possible (including a metallic taste in the mouth, increased salivation, swelling of the eyes and larynx).

Contraindications

dysfunction of the thyroid gland (hyperthyroidism);
heart failure;
Dühring's dermatitis herpetiformis;
simultaneous use of radioactive iodine;
children up to 6 years of age (up to 8 years - for spray);
pregnancy;
lactation period (breastfeeding);
hypersensitivity to iodine and other components of the drug.

Use during pregnancy and breastfeeding

Contraindicated for use during pregnancy and lactation (breastfeeding).

Use in children

Contraindicated for children under 6 years of age (under 8 years for spray).

Special instructions

The patient should be warned about the need to stop taking the drug and consult a doctor if signs of iodism appear.

This medicine is not for oral use and should not be inhaled or swallowed.

The drug contains about 19% ethanol (alcohol).

Drug interactions

The simultaneous use of Yox with other antiseptics for topical use in the mouth and pharynx, especially those containing hydrogen peroxide, is not advisable due to inactivation of the drug.

Analogues of the drug Yox

The drug Yox has no structural analogues for the active substance.

Analogs for therapeutic effect (medicines for the treatment of glossitis):

Hexoral;
Dr. Theiss Sage;
Imudon;
Stopangin;
Tantum Verde;
Fervex for sore throat.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

In the treatment of diseases of the oropharynx, local remedies are often used, which include Yox spray. This drug, which is also commercially available under the name Yox-Teva, is in great demand for inflammatory diseases of the oral cavity and sore throats, but can it be used in children?

Release form

Yox is available in the form of a spray intended for topical use. The drug is presented as a slightly opalescent or transparent solution with a red-brown color, a taste of iodine and a menthol aroma. One package contains a bottle with 30 ml of such liquid, instructions for use and an applicator (it can be placed in a plastic bag).

Another dosage form of the drug Yox is a solution, which is available in bottles of 50 and 100 ml. Before use, it is diluted with water, after which rinsing is carried out.

Compound

In Yox preparations, two components have an active effect:

Povidone-iodine. The content of this substance in 30 ml of spray is 2.55 grams.
Allantoin. This ingredient is presented in a dosage of 0.03 g per 30 ml of medicine.

Additionally, Yox contains levomenthol, purified water, 96% ethyl alcohol (at a dose of 6 grams per 30 ml), sodium citrate dihydrate, propylene glycol and citric acid monohydrate.

Operating principle

The drug Yox is classified as an antiseptic, since its use helps in the fight against viruses, microbes, protozoa and fungi. When the product comes into contact with the mucous membrane or skin, iodine is released from it, which destroys harmful pathogens. Thanks to allantoin, the medicine also has an anti-inflammatory effect and accelerates recovery processes in the mucosa.

Indications

Yox spray is used for diseases of the ENT organs and the oral cavity:

Sore throat.
Glossitis.
Aftah.
Stomatitis.
Tonsillitis.
Tonsilopharyngitis.

The drug is also in demand for treating the oropharynx during operations and after surgical treatment. In children, the drug is often used for streptococcal sore throat, as an addition to antibiotic therapy.

At what age is it allowed to take it?

Treatment with Yox in the form of a spray is prohibited before the age of 8 years. Yox solution can be used from 6 years of age. Earlier use of the medicine is not recommended due to the presence of alcohol in the composition, the need to follow directions during spraying (hold your breath), and the irritating effect of iodine on the mucous membrane.

Contraindications

Yox should not be used in the treatment of patients who have an intolerance to iodine or any other ingredient in the spray. Also, the medicine is not prescribed:

For hyperthyroidism.
For Dühring's dermatitis.
For heart failure.

Side effects

Occasionally, Yox causes an allergic reaction. It manifests itself as redness, itching and other symptoms, and therefore forces you to discontinue the drug. With long-term treatment with the spray, iodism may develop. Signs of this condition include a metallic taste in the mouth, increased salivation, swelling, and others.

We bring to your attention a series from the program “Children’s Doctor” where a pediatric otolaryngologist and pediatrician will tell us what to do with a child’s sore throat.

Instructions for use and dosage

To distribute the drug evenly in the oral cavity, an applicator and a mechanical sprayer are used. Before first use, make sure that the applicator is not damaged and rinse it with hot water. After removing the cap from the sprayer, you need to install the applicator on top of the medicine bottle, and then do several sprays. Thanks to these actions, the drug will continue to enter the oral cavity in the required dose.

To spray the medicine, you need to insert the applicator tube into the oral cavity 2-3 centimeters, and then tell the child to hold his breath (so as not to inhale Yox) and press the applicator twice. In this case, the tube should be directed to the right for the first spray, and to the left for the second. Irrigation frequency is from 2 to 4 times a day, but if necessary, treatment can be carried out every four hours. After spraying, the applicator should be rinsed with water.

Overdose

There is no evidence of a negative reaction to an increased dose of Yox spray.

Interaction with other drugs

You should not simultaneously treat the throat or oral cavity with Yox spray and other antiseptics, especially if they contain hydrogen peroxide. In addition, Yox treatment should not be administered during radioactive iodine treatment.

Terms of sale

Purchasing Yox spray at a pharmacy does not require a prescription from a pediatrician or ENT doctor. On average, one bottle costs 230-250 rubles.

Storage conditions and shelf life

You need to store Yox spray or solution at home in a place where the drug cannot be reached by a small child. The optimal temperature conditions for such a medicine are considered to be the range from +10°C to +25°C. The shelf life is 4 years, and the solution is 5 years.