Medullary nephrocalcinosis of the kidneys. Medullary nephrocalcinosis

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Nephrocalcinosis

What is Nephrocalcinosis - Nephrocalcinosis

What is Nephrocalcinosis -- a disease that belongs to the group of calcifications. Calcinosis, also known as calcareous degeneration, is a form of pathology of calcium metabolism in the body: calcium salts precipitate from liquids (they were dissolved in liquids), depositing in the interstitial tissue and cells.

is a variant of metastatic calcification, in which calcium salts are diffusely deposited in the kidney tissue, which causes inflammatory-sclerotic changes and renal failure. Types of nephrocalcinosis

  • according to clinical manifestations:
  • primary

secondary

With primary, no changes in the kidneys are observed, but with secondary, kidney pathology occurs along with the processes of precipitation of calcium salts. Nephrocalcinosis can occur, for example, with alkaline milk syndrome or Burnett's syndrome. It is likely to occur in children who are transferred from natural feeding to cow's milk with herbal supplements. Read more about the reasons below.

What provokes / Causes of Nephrocalcinosis:

  • Among the causes of primary nephrocalcinosis are:
  • conditions in which too much calcium enters the body (familial and idiopathic hypercalcemia of newborns, hypervitaminosis D, Burnett's syndrome, Lightwood-Fanconi syndrome, Addison's disease, sarcoidosis, excessive intravenous administration of calcium salts)
  • conditions in which mobilization of calcium from bones occurs (tumors of bones and some organs, hyperparathyroidism, myeloma, metastases of tumors in the bones, post-castration and corticosteroid osteoporosis, postmenopausal osteoporosis, osteomyelitis, multiple bone fractures, Paget's disease, neuroplegia, immobilization, thyrotoxicosis)
  • hypophosphatasia (impaired calcium binding in bones)
  • tubulopathies and various diseases that occur with acidosis (chronic tubular acidosis of Buttler-Albright, transient tubular acidosis of Lightwood, oculocerebrorenal syndrome of Lowe, glucose-phosphate aminoaciduria de Toni-Debreu-Fanconi, hyperchloremic acidosis, respiratory acidosis)

Secondary nephrocalcinosis: causes

Among the most likely reasons are:

  • radiation nephrosclerosis
  • ischemic cortical necrosis of the kidneys
  • abuse of sulfonamides, thiazide diuretics, phenacetin, ethacrine diuretics, anthranil diuretics
  • uncontrolled use of amphotericin
  • mercury salt poisoning

Nephrocalcinosis can be caused by renal and extrarenal acid-base balance disorders. This is mainly metabolic and respiratory acidosis, in rare cases it is metabolic alkalosis. With these diseases, the level of calcium in the blood increases and its excretion in the urine increases. The degree of calciuria can be a maximum of 400-600 milligrams in 24 hours.

Pathogenesis (what happens?) During Nephrocalcinosis:

Pathogenesis of calcinosis

The matrix for calcium salts inside cells is lysosomes and mitochondria. Outside the cells, these are collagen and elastic fibers plus glycosaminoglycans of the main substance of the interstitial tissue. Calcium salts can be deposited in the form of grains, pockets of lime, which are distributed more or less in different cases. In areas with lime, bone tissue may form, and around it there will be inflammation and a fibrous capsule.

Local and general factors play a role in the pathogenesis of calcinosis. Therefore, forms of calcification, in addition to the criterion of the location of calcifications, are distinguished according to pathogenetic factors. Calcification can be metastatic, metabolic and dystrophic, which is also known as (petrification).

Pathogenesis of nephrocalcinosis

There is an abnormally large influx of calcium into the kidneys; it accumulates in the epithelial cells of the human kidneys. When too much intracellular calcium accumulates, cell degeneration occurs. The deposited calcium enters the interstitial space or the lumen of the tubules. During this process, cylinders are formed that block the tubules, causing their dilation and atrophy. Salt deposits in the interstitium cause a lymphoproliferative reaction, followed by nephrosclerosis.

With nephrocalcinosis, infection and stone formation occur, so this disease becomes the source of pyelonephritis and/or hydronephrosis. The pathogenesis of primary nephrocalcinosis in children and adults is characterized by the fact that the proximal part of the nephron is affected first, and the glomerulus and distal part are affected later. If nephrocalcinosis is secondary, then calcium is deposited simultaneously in the distal nephron.

Symptoms of Nephrocalcinosis:

With nephrocalcinosis there is usually an underlying disease. Therefore, two groups of symptoms appear at once, as well as concomitant hypercalcemia. Calcium toxicity causes the following symptoms:

  • fatigue
  • general weakness
  • vomit
  • dry skin
  • thirst
  • constipation
  • joint deformity
  • joint pain
  • mental instability
  • keratoconjunctivitis
  • seizures
  • shortening of systole duration on the electrocardiogram

With kidney damage, when the transport of substances in the tubules is disrupted and their sensitivity to antidiuretic hormone is lost, the following occur:

  • isosthenuria
  • polyuria
  • attacks of renal colic are likely (during the passage of stones)
  • pain in the lumbar region

Persistent changes in the urinary sediment are often observed; it contains a large number of bacteria, leukocytes, salt casts and red blood cells. Later, edema, proteinuria, and arterial hypertension are recorded. During this period, as a rule, symptomatic and laboratory signs of kidney failure appear.

Complications:

  • Chronic renal failure
  • Obstructive uropathy
  • Stones in the kidneys

Diagnosis of Nephrocalcinosis:

Diagnosis of nephrocalcinosis at the stage of its appearance is based on information obtained using a puncture biopsy of the kidney. A method such as plain radiography is relevant only in severe cases, when the calcification of the renal pyramids is significantly pronounced.

To approximately determine the degree of calciuria, diagnosticians sometimes use the Sulkovich test. To clarify the cause of the disease, the patient’s urine and blood are examined for calcium and phosphorus content, and the activity of parathyroid hormone in the blood and alkaline phosphatase are determined. It is necessary to identify urinary excretion of hydroxyproline, acid-base balance, creatinine and phosphate clearance.

When diagnosing, nephrocalcinosis is distinguished from a spongy kidney, in which the cystic spaces are filled with condensate of calcium salts.

Treatment of Nephrocalcinosis:

It is necessary to eliminate the cause of calcium metabolism disorders in the body as early as possible. For severe dehydration, infusions are made of a solution of sodium bicarbonate or sodium citrate, potassium citrate and aspartate for acidosis, and for alkalosis, infusions of sodium and ammonium chloride are given.

If hypercalcemia is moderate, the patient is advised to adhere to a diet with foods that contain little or no calcium. Vitamin B6 and infusion of magnesium sulfate solution are attributed. Treatment of acute hypercalcemia consists of infusion of a solution of magnesium sulfate, sodium phosphate, sodium EDTA. Doctors may prescribe the administration of thyrocalcitonin or prednisolone.

Treatment of progressive renal failure is mandatory with hemodialysis. It is important to adequately treat pyelonephritis, which causes progression of kidney failure. With secondary nephrocalcinosis, it is important to identify and treat the underlying disease, which is the etiological factor.

Forecast with effective treatment at the onset of the disease, good. Patients with progressive nephrocalcinosis have an unfavorable prognosis, because in advanced cases uremia occurs, threatening the health and life of the patient.

Prevention of Nephrocalcinosis:

  • You should get the optimal amount of calcium (no more and no less) in your daily diet.
  • You should not take calcium supplements without a doctor's prescription.
  • It is important to treat kidney diseases in a timely manner.
  • If suspicious symptoms or any health problems appear, you should immediately consult a general practitioner, family doctor or highly specialized doctor.

Which doctors should you contact if you have Nephrocalcinosis:

Nephrologist

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The kidneys are a paired organ that performs a number of functions important for human life.

Destructive conditions in them lead to serious deterioration in health.

One of these pathologies is nephrocalcinosis. The disease is characterized by a violation of calcium metabolism.

The disease develops when calcium metabolism is impaired (calcification, calcification), where mineral salts are diffusely deposited and crystallize, causing inflammation and sclerotic changes in the kidney tissues:

  • cortex (consisting of nephrons);
  • medulla (formed by renal pyramids).

What is the danger of nephrocalcinosis of the kidneys?

Excess calcium provokes changes in tissue cells - dystrophy.

Mineral salts accumulate in the intercellular space and lumens of the tubules, clogging them.

As a result, the epithelial tissue of the organ is replaced by scar tissue.

The process causes kidney failure and nephrosis.

Nephrocalcinosis is the impetus for the development and. The pathology also affects other organs of the genitourinary system, in particular the bladder is at risk.

Types and forms

Based on the localization of deposits in the organ, doctors classify nephrocalcinosis into:

  • Cortical, characterized by the accumulation of mineral in the epithelial cells of the cortical layer. Factors that provoke the appearance are most often kidney damage of an infectious nature, glomerulonephritis.
  • Medullary, formed during the crystallization of Ca salts in the medulla of the organ and pyramids. The impetus for the formation will be tubular acidosis and hyperparathyroidism.

Medullary nephrocalcinosis

Depending on development factors, the disease is divided into two types:

  1. Primary affects a healthy organ due to a disturbance in calcium-phosphorus metabolism, in which the Ca content in the blood increases. It also increases the excretion of the mineral through the urinary tract.
  2. Secondary is formed in areas of the organ affected by other diseases.

Causes

The development of primary type pathology is preceded by the following factors:

  • Hypercalcemia, when excess Ca enters the body. This effect can be achieved by dieting and taking medications enriched with the mineral. Increased intake of calcium is provoked by nephropathy of newborns and congenital tubulopathy.
  • Disturbances in the acid-base balance, characterized by acidosis and alkalosis.
  • Oversaturation with vitamin D, which raises the level of the mineral.
  • Increased excretion of Ca from bone tissue occurs with hyperparathyroidism, osteoporosis, osteomyelitis, myeloma, neuroplegia, thyrotoxicosis, and with multiple bone fractures.
  • Malignant neoplasms.
  • Disorders of mineral binding in bone tissue - hypophosphatasia.

Nephrocalcinosis also often occurs with congenital kidney pathologies and ailments that arise from calcium metabolism disorders.

The secondary type develops against the background:

  • Poisoning with mercury compounds.
  • Excessive use of diuretics, antimicrobial agents (sulfonamides).
  • Long-term use of analgesics.
  • Overdose of the antifungal antibiotic "Amphotericin".
  • Organ damage from radiation.
  • Necrosis of renal cortex tissue due to insufficient blood supply. An example of a pathology is ischemic necrosis.

In children

The condition is most common in premature infants in the first year of life, and slightly less common in older children. This is associated with a hereditary disorder of calcium metabolism in the mother, which subsequently affects the health of the child, and with idiopathic hypercalcemia. The disease is characterized by frequent regurgitation, the formation of a dense sediment in the urine and urine.

Symptoms

Nephrocalcinosis develops against the background of the underlying disease. Therefore, two groups of signs appear:

  1. Calcium intoxication is accompanied by nausea, vomiting, general weakness, fatigue, and drowsiness. There are sudden mood swings, itching and severe peeling of the skin. The joints become deformed and hurt, the conjunctiva and cornea of ​​the eyes become inflamed. A person suffers from cramps in the intestines and stomach, periodic constipation. The pathology is accompanied by convulsive seizures and loss of motor coordination.
  2. If there is a violation of the transport of substances in the renal tubules and a decrease in sensitivity to the peptide hormone, then they are characterized by the appearance of monotonous diuresis and pain in the lumbar region. And also observed, strong thirst. Over time, swelling appears and blood pressure rises.

Diagnostics

In the early stages, the pathology practically does not show characteristic signs.

  • An informative method for determining nephrocalcinosis at an early stage is puncture, since with some instrumental studies the changes remain unnoticeable.
  • Ultrasound of internal organs is performed in the first stages for an accurate diagnosis or as the main way to recognize the disease.
  • X-ray, computed tomography and magnetic resonance imaging are prescribed in the last phase. The images clearly show linear calcium salts and renal pyramids.
  • To clarify the disease factor, blood and urine are taken, which are subsequently examined for calcium and phosphorus content. At the same time, the degree of calciuria is determined, and the biochemistry of the resulting material is carried out.
  • Kidney function is assessed by testing for the presence of creatinine and alkaline phosphatase.
  • In order to determine the form of the disease, the activity of parathyroid hormone in the blood is examined.

Treatment

Therapy for nephrocalcinosis begins with lowering Ca levels. In the first stages:

  • menu is being adjusted;
  • Treatment with folk remedies is allowed;
  • It is recommended to take B vitamins, and in some cases, hormonal drugs such as Calcitonin and Prednisolone.

In case of obvious dehydration, intravenous infusion of solutions is performed:

  • sodium bicarbonate or chloride;
  • potassium citrate or aspartate.

During hypercalcemia, the following is prescribed:

  • sodium phosphate;
  • magnesium sulfate.

If renal failure is detected, hemodialysis is performed.

Alternative medicine

Herbal medicine is an alternative way to relieve the symptoms of kidney disease.

Tea made from strawberry and wild strawberry leaves has a diuretic effect and improves the functioning of the urinary organs, even though the plants contain calcium.

Viburnum, sea buckthorn and gooseberries are good diuretics; in addition, the fruits relieve inflammation.

A decoction for baths based on birch and sage leaves normalizes blood circulation in the vascular bed of the kidneys.

Diet

During the treatment of nephrocalcinosis, foods rich in Ca and vitamin D are excluded.

Removed from the diet:

  • all types of cheeses;
  • sesame;
  • sunflower seeds and oil based on it;
  • halva;
  • mustard;
  • almond;
  • walnuts.

Do not use:

  • products made from wheat and rye flour;
  • beans;
  • oatmeal.

Canned food, salty, spicy, smoked and fried foods are also prohibited.

Forecast

The prognosis with timely therapy aimed at eliminating the underlying causes is positive.

Experts give a negative assessment to patients who have progressive nephrocalcinosis. Since during illness the body is poisoned by harmful substances, which can be life-threatening.

Prevention

To prevent the development of the disease, doctors advise:
  • spend more time outdoors;
  • exercise;
  • to refuse from bad habits.

It is important to consume the required amount of Ca with food every day.

ICD code

According to the international classification of diseases, nephrocalcinosis is assigned code N29.8* - “Other lesions of the kidneys and ureters in other diseases classified in other headings.”

To prevent nephrocalcinosis of the kidneys, experts recommend adhering to a healthy lifestyle and monitoring your diet. If, however, changes in health status, pain in the lumbar region and symptoms characteristic of pathology are noted, it would be wise to consult a therapist, urologist or nephrologist. Do not forget that the sooner the disease is eliminated, the faster the recovery will come.

Metabolic disorders sometimes lead to deposits of calcium salts in the kidneys.

Calcifications in the kidneys are a dense stone sediment, under which the kidney tissue dies.

Cell necrosis promotes their replacement with connective tissue, forming a kind of scar.

The affected tissues of the organ are not able to filter urine, which sometimes leads to a malfunction in its functioning. The disease is diagnosed in both children and adults.

In the kidneys, there are primary and secondary calcifications. Nephrocalcinosis is classified in a similar way - a condition in which formations appear in the organ.

Primary calcifications appear as a result of congenital diseases and various developmental disorders. This process is called primary nephrocalcinosis. It affects the renal parenchyma.

Nephrocalcinosis is caused by:

  • increased levels of calcium in the body;
  • loss of calcium from the skeletal system;
  • excess vitamin D content, which regulates the concentration of calcium in the blood.

Secondary calcifications appear after inflammatory diseases, especially after thyroid diseases and other endocrine disorders.

Symptoms of the disease:

  • frequent urination;
  • the appearance of protein in the urine;
  • constant thirst;
  • smell of acetone from the mouth;
  • change in skin color;
  • swelling of the limbs;
  • pain in the lumbar region;
  • high blood pressure.

Patients complain of poor appetite, weakness and decreased performance.

Large formations block the lumen of the ureter, causing severe pain and the appearance of blood in the urine. requires urgent hospitalization.

Nephrocalcinosis may be a sign. But if the formations are isolated, then there is no need to worry about the likelihood of cancer.

Diagnosis, treatment and prevention

The disease often occurs without any symptoms. A number of tests and studies are carried out for diagnosis.

Sometimes formations are discovered during the diagnosis of other diseases during an ultrasound examination. X-ray shows a very advanced stage of nephrocalcinosis. In some cases, a puncture biopsy of organ tissue is prescribed.

Calcification of the parenchyma of the right kidney

If calcification is detected in the kidney, treatment pays a lot of attention to eliminating the causes of metabolic disorders in the body. Removing formations surgically is ineffective. Sometimes the problem is accompanied by infectious and inflammatory processes in the urinary system. Then therapy is aimed at treating these manifestations.

If the composition of urine changes and there are no other manifestations, the patient is recommended to limit treatment to a special diet and taking vitamins.

You should exclude from your diet foods rich in calcium, such as cheese, as well as parsley, legumes, wheat, condensed milk, black bread, and cabbage.

In advanced cases of the disease, treatment includes taking painkillers and medications to improve the functioning of the organ.

The therapeutic course is aimed at treating dysfunctions such as pyelonephritis and arterial hypertension.

Children and adults are prescribed the same treatment.

In case of imbalance of calcium and magnesium, intravenous administration of saline solutions is prescribed. The patient's advanced condition requires hemodialysis or an organ transplant.

Physical activity will help improve the flow of urine, along with which unnecessary formations will be removed. You should avoid taking medications that have a negative effect on the organ, after consulting with your doctor.

The prognosis of the disease is very favorable. But if the disease is diagnosed too late, it can lead to serious kidney problems.

If calcifications are detected, work in hazardous industries and hot shops is prohibited.

Traditional medicine in the treatment of kidney tumors

Birch sap is a medicine that has no contraindications for the treatment of kidney diseases.

It removes salts perfectly. The juice is preserved with honey and citric acid so that it can be consumed all year round.

Birch buds have the strongest diuretic effect. Five grams are poured into one glass of boiling water, infused and drunk one-third of a glass throughout the day. Bear's ear herb also helps with salts.

To prepare the infusion, take one part of the herb and forty parts of boiling water. Take the infusion three times a day, twenty milliliters.

Disease prevention

Preventive measures to prevent the disease come down to proper nutrition and consumption of healthy foods.

More attention should be paid to a healthy lifestyle, including reasonable physical activity and sufficient physical activity.

The quality of drinking water is also of great importance for the prevention of disease.

View on topic

Ultrasound of early nephrocalcinosis of the kidneys:

So, if calcifications are diagnosed early, they can be easily cured with folk remedies and diet. But the asymptomatic course of the disease leads to a malfunction of not only the kidneys, but also the entire urinary system: the development of renal failure and uremia. If a large number of formations are diagnosed, this may indicate the presence of cancer. Prevention of the disease consists of regular examinations by a nephrologist, a balanced diet and adherence to healthy lifestyle standards.


The kidneys are an important organ of the urinary system, with the help of which harmful and waste substances and toxins are removed from the body.

It is not surprising that they are often exposed to various diseases, one of which is nephrocalcinosis.

Calcifications are dense deposits that look like rocky sediment consisting of calcium salts. Such deposits can occur in many organs: lungs, uterus, thyroid gland, etc.

general information

If we consider these formations in relation to the kidneys, then they can form both in the kidney itself and on the walls of its tubules.

Crystallization of calcium salts causes the gradual death of organ cells located under the sediment, resulting in the formation of scar tissue.

Sclerotic and inflammatory processes of this nature almost always lead to chronic renal failure.

Reasons for appearance

The main factor leading to the occurrence of deposits is a metabolic disorder, in particular, calcium and phosphorus in the body.

Most often, this is hypercalcemia - too high a calcium content in the blood, and hypercalciuria - the excretion of this element in the urine.

In such a situation, the organ simply cannot cope with the load. Depending on the cause and clinical picture of the disease, there are 2 types:

  • primary, which affects a generally healthy organ;
  • secondary, in which a sediment forms in conjunction with pathological changes in the kidney.

The following factors lead to the primary type:

  • the intake of large amounts of calcium into the body, which can occur due to a special diet or taking certain medications, as well as certain diseases;
  • excessive levels of vitamin D, which affects calcium levels;
  • various types of bone lesions, for example, osteoporosis, bone tumors, etc.;
  • some malignant tumors;
  • improper release of calcium, which may be caused by hormonal diseases or diseases of the kidneys themselves;
  • hyperparathyroidism;
  • sarcoidosis

The causes of secondary nephrocalcinosis are:

  • poor blood circulation in the kidneys caused by atherosclerosis, thrombosis, etc.;
  • organ damage from radiation;
  • intoxication caused by mercury salts;
  • regular use of certain medications - thiazide, ethacrine, sulfonamides, etc.

Thus, this disease can be directly caused by disorders in the kidneys themselves, or by extrarenal causes.

Clinical picture

Symptoms of the disease differ between primary and secondary nephrocalcinosis.

At the initial stage, the formation of calcifications is very difficult to suspect, since with minor damage to one kidney, the second takes on part of the load. Thus, there are no pronounced symptoms, but they still exist:

  • general weakness and fatigue, decreased endurance;
  • dehydration, manifested in thirst, dizziness, change in urine color, etc.;
  • constipation;
  • itching and dry skin;
  • emotional tension;
  • trembling of limbs, convulsions;
  • joint pain;
  • blood pressure levels may increase.

These symptoms may indicate too much calcium in the blood. If the following signs are identified, we can talk about damage to the organ itself and the onset of a secondary form. During this period, renal tissue cells die and calcium is deposited into deeper layers.

The kidney tubules become blocked, leading to impaired renal function. At this time, connective tissue grows and the parenchyma is replaced by scar tissue. This process calls:

  • pain in the lumbar region and;
  • decrease in the specific gravity of urine excreted - ;
  • the volume of urine excreted increases sharply;
  • , and red blood cells.

In addition, this disease causes other kidney diseases.

Possible complications

Impaired functioning of the excretory system in most cases provokes the development of inflammatory processes, pyelonephritis, etc. In addition to disorders in the kidneys themselves, nephrocalcinosis also has a negative impact on neighboring organs.

In particular, on the bladder, where calcium deposition can also begin. Because of this, the water-salt balance is disrupted.

In most cases, chronic renal failure develops quite quickly. Calcifications in the plural can indicate malignant or benign neoplasms. They themselves can cause development.

How to diagnose

Often the onset of the disease is not accompanied by any symptoms and nephrocalcinosis is discovered accidentally, most often during an ultrasound.

  • is an informative study, especially in the early stages.
  • allows you to detect only fairly large deposits, as well as associated diseases;
  • biochemistry of blood and urine determines the level of calcium, phosphorus, etc.;
  • X-rays allow you to view formations in detail;
  • MRI and CT - are prescribed if necessary, when a more detailed picture is needed, and ultrasound is not effective;
  • allows you to detect only fairly large deposits, as well as associated diseases;
  • biochemistry of blood and urine determines the level of calcium, phosphorus, etc.;
  • X-rays allow you to view formations in detail;
  • MRI and CT - are prescribed if necessary, when a more detailed picture is needed, and ultrasound is not effective;
  • a biopsy is an informative study, especially in the early stages.
  • allows you to detect only fairly large deposits, as well as associated diseases;
  • biochemistry of blood and urine determines the level of calcium, phosphorus, etc.;
  • X-rays allow you to view formations in detail;
  • MRI and CT - are prescribed if necessary, when a more detailed picture is needed, and ultrasound is not effective;
  • a biopsy is an informative study, especially in the early stages.
  • allows you to detect only fairly large deposits, as well as associated diseases;
  • biochemistry of blood and urine determines the level of calcium, phosphorus, etc.;
  • X-rays allow you to view formations in detail;
  • MRI and CT - are prescribed if necessary, when a more detailed picture is needed, and ultrasound is not effective;
  • a biopsy is an informative study, especially in the early stages.
  • allows you to detect only fairly large deposits, as well as associated diseases;
  • biochemistry of blood and urine determines the level of calcium, phosphorus, etc.;
  • X-rays allow you to view formations in detail;
  • MRI and CT - are prescribed if necessary, when a more detailed picture is needed, and ultrasound is not effective;
  • a biopsy is an informative study, especially in the early stages.
  • allows you to detect only fairly large deposits, as well as associated diseases;
  • biochemistry of blood and urine determines the level of calcium, phosphorus, etc.;
  • X-rays allow you to view formations in detail;
  • MRI and CT - are prescribed if necessary, when a more detailed picture is needed, and ultrasound is not effective;
  • a biopsy is an informative study, especially in the early stages.

Therapy methods

The entire process of treating nephrocalcinosis involves, first of all, the elimination of all causes that cause the deposition of calcium salts, as well as therapy for the treatment of concomitant kidney diseases and their symptoms. Surgical intervention in this case is ineffective.

Eliminating the cause

First of all, it is necessary to take measures to reduce the level of calcium in the blood. To do this, follow a certain diet and change your lifestyle.

More time should be devoted to sports, as it provokes the outflow of urine, which reduces the retention time of toxins in the body.

A special place is occupied by a diet appropriate. It helps remove toxins from the body. It consists of refusing or significantly reducing foods that contain calcium and vitamin D. These are foods such as:

  • sesame and sunflower seeds, poppy seeds, halva;
  • milk and dairy products: cheeses, feta cheese, cottage cheese and sour cream, condensed milk;
  • walnuts and nutmeg, almonds;
  • black bread, bran and wheat flour, oatmeal;
  • garlic, cabbage, dill and parsley.

At the same time, salt should also be excluded from the diet. Lemon and its acid, cumin and cilantro, and cinnamon are desirable for consumption. Diuretics can be prescribed, but do not increase the volume of daily fluid.

Symptomatic treatment

Calcium levels can also be regulated with the help of certain medications. For this purpose, solutions of sodium bicarbonate and citrate are used. In some cases, sodium chloride or potassium aspartate are indicated. B vitamins are a must.

Treatment of diseases associated with nephrocalcinosis is carried out: renal failure, urolithiasis and others, using anti-inflammatory and analgesic drugs. In severe cases, even a kidney transplant is used.

Features for children

Nephrocalcinosis in children usually develops much faster than in adults. The cause is usually a congenital disorder of the kidneys or metabolism. In addition, one of the reasons may be the transfer of an infant to cow's milk with herbal supplements.

In addition, a child’s body cannot fight this disease for a long time.

Therefore, at the first suspicion, you need to immediately hospitalize the child and conduct a thorough examination.

The treatment is almost identical to the generally accepted one. The only difference is in the treatment of concomitant diseases.

Prognosis and prevention

The prognosis directly depends on the stage of the disease and the effectiveness of treatment. If nephrocalcinosis is detected at the very beginning of its development, then the prognosis with proper treatment is positive. This means that it is possible to maintain the organ and its function at the proper level.

In advanced cases, serious complications and consequences arise that require hemodialysis and, possibly, an organ transplant. Death is also possible.

As such, there is no prevention against the deposition of calcium salts. It is also important to drink water and exercise.

You should not take calcium supplements without a doctor's prescription. One of the important points is intensive treatment of inflammatory and infectious diseases of the urinary system.

It is important to monitor your health and, at the slightest suspicion, consult a doctor.

Metabolic disorders lead to malfunction of all internal organs. Kidneys are no exception. If calcium metabolism is disturbed, a disease can develop - nephrocalcinosis. Renal pathology in an advanced state often leads to serious consequences. To prevent such an outcome, it is important to know the symptoms of the disease, treatment methods and prevention rules.

What is nephrocalcinosis in children and adults

Nephrocalcinosis is characterized by the deposition of calcium salts in the parenchyma (tissue filling the organ) and tubules of the kidneys.

As a result, calcifications are formed - a dense stone sediment, under which the kidney tissue dies.

With nephrocalcinosis, calcium salts accumulate in the organ

The disease can occur in both adults and children, including infants.

  • The pathology is accompanied by the following disorders:
  • deterioration of blood circulation in the kidney;
  • increased load on the urinary organs;
  • acute inflammatory process in the organ;
  • scarring of kidney tissue;

development of renal failure.

  • In medicine, the disease has other names:
  • kidney calcification;
  • metastatic calcification of the kidney;
  • calcareous metastases in the kidney;

calcareous kidney dystrophy.

Types of nephrocalcinosis

  • Depending on the causes of nephrocalcinosis, there are:
  • primary - accompanied by the deposition of calcium salts in healthy renal tissues. Occurs as a result of various diseases and metabolic disorders in the body;

secondary - fixation of calcium deposits occurs on the scar tissue of the kidney. Scars are formed as a result of exposure of the kidney tissue to chemicals and toxic substances.

  • Based on the number of affected organs, nephrocalcinosis is divided into two types:
  • unilateral,

double-sided

  • Depending on the location of calcifications in the kidney, nephrocalcinosis occurs:
  • medullary - calcium salts are located in the renal pyramids;

cortical - calcium salts are formed in the cortical layer of the kidney.

With meddular nephrocalcinosis, calcium salts accumulate in the cortex, with cortical nephrocalcinosis - in the renal pyramids

Causes of pathology development in children and adults

  • vitamin D, which is produced under the influence of ultraviolet radiation from the sun and also enters the body with food. Vitamin D stimulates the resorption (release) of calcium from bone tissue. With an excess of vitamin D, the calcium content in the blood also increases, which leads to the development of nephrocalcinosis. Most often, excess vitamin D is observed when drugs containing this substance are abused;
  • parathyroid hormone, formed as a result of the work of the parathyroid glands. There is a “double feedback” between parathyroid hormone and calcium. If the level of calcium in the blood decreases, the parathyroid glands increase the production of parathyroid hormone. This increases calcium levels in the blood. In turn, calcium acts on the receptors of the parathyroid glands, which causes them to stop releasing parathyroid hormone. In the presence of various pathologies of the parathyroid glands, the production of particulate hormone may be disrupted, the amount of calcium in the blood increases, and prerequisites arise for the development of nephrocalcinosis;
    The functioning of the parathyroid glands affects the level of calcium in the blood
  • calcitonite is a thyroid hormone that stimulates the absorption of calcium by bone tissue, as well as accelerating the excretion of the microelement from the body by the intestines and kidneys. Calcitonite is produced in small quantities during intense physical activity, which entails an increase in calcium levels in the blood;
    Thyroid hormone calcitonite helps reduce calcium levels in the blood
  • phosphorus, which enters the body with food. With phosphorus deficiency, the calcium content in the blood increases, calcium salts accumulate in blood vessels and internal organs, including the kidneys.

Other factors influencing the development of nephrocalcinosis:

  • congenital renal pathologies;
  • (inflammatory process in the kidney tubules);
  • (inflammatory process in the renal glomeruli);
  • hereditary predisposition;
  • effects of radiation, toxins, mercury on the kidneys;
  • abuse of antibiotics, diuretics and other drugs.

Video: excess calcium in the body

Symptoms of the disease

In the initial stage of development, the disease may not manifest itself in any way and may not bother the person. As the pathology progresses, when calcium deposits begin to affect the urinary function of the kidneys, symptoms appear:

  • frequent urination;
  • an increase in daily diuresis (the amount of urine excreted by the kidneys per day);
  • lethargy and fatigue;
  • decreased appetite;
  • increased gas formation;
  • nausea:
  • swelling of the arms and legs;
  • high blood pressure;
  • constant thirst;
  • pain in the heart area;
  • arrhythmia;
  • itching of the skin.

Symptoms in infants have some features:

  • the child often spits up;
  • urine becomes dark and cloudy;
  • The baby may be capricious and refuse to breastfeed.

In older children, the signs of nephrocalcinosis are similar to the general symptoms.

Dangerous symptoms

If the calcifications reach a large size and obstruction (blockage) of the ureter occurs, an attack of renal colic may occur, which is accompanied by severe symptoms:

  • a sharp pain syndrome appears in the kidney area, then spreads to the upper abdomen. Pain can also be localized in the back, legs, groin, under the ribs, in the area of ​​the ureter;
  • a person develops profuse vomiting, which contributes to rapid dehydration of the body;
  • blood appears in the urine;
  • severe dizziness occurs;
  • Body temperature rises to 38–40 degrees.

When large calcification gets into the ureter, renal colic occurs, which is accompanied by severe pain.

During renal colic, a person’s pain is so severe that pain shock may occur. If symptoms characteristic of an attack occur, it is necessary to urgently call an ambulance.

Diagnosis of nephrocalcinosis

If nephrocalcinosis is suspected, laboratory tests are prescribed:

  • general urine analysis;
  • Sulkovich test, which determines the calcium content in urine;
  • general blood analysis;
  • with determination of calcium and phosphorus content;
  • blood test for thyroid and parathyroid hormones.

Instrumental diagnostic methods are also used:


Diagnosis of the disease in children and adults is carried out according to the same scheme.

Differential diagnosis

Nephrocalcinosis should be differentiated from a spongy kidney, a congenital pathology in which small cysts form in the area of ​​the renal pyramids. The internal contents of cysts are condensation of calcium salts.

Treatment

Surgery is not used to treat nephrocalcinosis; preference is given to conservative methods.

Drug therapy

The following drugs can be used to treat nephrocalcinosis in children and adults:

  • anti-inflammatory drugs (Canephron, Cyston);
  • antibiotics (Cefotaxime, Augmentin) - prescribed for bacterial infection, which often accompanies progressive nephrocalcinosis;
  • to restore metabolism, infusions of sodium bicarbonate or sodium citrate are used;
  • diuretics (Veroshpiron, Furosemide, Uractone) - help increase diuresis, due to which excess calcium is removed from the body;
  • B vitamins - improve kidney function.

Diuretics are very rarely used to treat children under 1 year of age. The exception is the appearance of severe edema.

Photo gallery: medications used for nephrocalcinosis

Canephron eliminates inflammatory processes in the kidneys Cefotaxime is used for bacterial infections in the kidneys B vitamins improve kidney function Furosemide enhances renal excretory function

Physiotherapy

Physiotherapy procedures are used at the initial stage of development of the disease and can significantly improve the patient’s physical performance. The most effective include the following physiotherapy procedures:

  • ultraphonophoresis - relieves pain, eliminates inflammatory processes in the kidneys. Under the influence of ultrasound, drugs penetrate deep into the tissue, which speeds up the healing process. The procedure has no contraindications and does not cause side effects;
  • Magnetic therapy - helps strengthen the body's defenses, improves blood circulation in the kidneys, enhances the excretory and filtration functions of the organ, and reduces pain. There are no contraindications to the procedure, so magnetic therapy is suitable for treating both adults and children.

Diet and drinking regime

For nephrocalcinosis, treatment table No. 7, developed by the Soviet nutritionist M.I. Pevzner, is used. Basic diet rules:

  • you need to eat often (4-5 times a day) and in small portions so as not to overload the kidneys;
  • the amount of fluid consumed per day should be at least two liters;
  • the use of salt in the diet, which contributes to dehydration of the body, is reduced;
  • Spicy, pickled, smoked, fried, fatty foods are not used in the diet;
  • food is boiled, stewed, steamed, baked;
  • Alcoholic and carbonated drinks, coffee, and strong black tea are excluded.

And also in case of illness, the use of foods high in calcium is limited:

  • dairy products - cottage cheese, kefir, cheese, milk, yoghurts;
  • legumes - soybeans, lentils, peas, beans;
  • some vegetables - parsley, dill, basil, broccoli, white cabbage, potatoes;
  • dried apricots;
  • oatmeal;
  • sesame;
  • pistachios.

Photo gallery: prohibited foods for nephrocalcinosis

Vegetables with a pungent taste are prohibited for nephrocalcinosis Fast food puts stress on the kidneys Alcoholic drinks are toxic to the kidneys Dairy products contain a lot of calcium
Sesame seeds contain a lot of fat and calcium,

  • any cereals except oatmeal;
  • pasta;
  • fruits;
  • berries;
  • vegetables (except prohibited);
  • lean meats and fish;
  • green tea;
  • drink with chicory;
  • herbal decoctions and infusions.

Photo gallery: useful foods for nephrocalcinosis

Green tea removes toxins from the body Fruits contain all the vitamins necessary for the body If you have nephrocalcinosis, give preference to lean meats
For nephrocalcinosis, you can use any cereal except oatmeal Feel free to use cucumbers and tomatoes in your diet

Folk remedies

Some medicinal herbs can improve kidney function in nephrocalcinosis. However, it should be remembered that any plant has contraindications and you should consult your doctor before using it.

Remedy for nephrocalcinosis with flax seeds

The decoction helps remove calcifications from the kidneys and also relieves pain symptoms.

Step-by-step instructions for preparing the product:

  1. Pour one tablespoon of flax seeds into a glass of water.
  2. Bring the mixture to a boil, cool.
  3. Add a few drops of lemon juice to the solution.
  4. Use the product every 2 hours for two days (sleep time is not taken into account). Single dosage - 50 ml.

Rosehip infusion

The product is a diuretic and also helps improve immunity.

Cooking process:

  1. Pour three tablespoons of rose hips into 0.5 liters of boiling water.
  2. Simmer over low heat for 10 minutes.
  3. Leave the broth for an hour, then filter.
  4. Consume three times a day an hour after meals. Take 150 ml of decoction at one time, the course of treatment is two weeks.

Anti-inflammatory infusion of corn silk, birch leaves and burdock root

The infusion relieves inflammation in the kidneys and increases urine output.

Step by step recipe:

  1. Place two teaspoons of corn silk, the same amount of birch leaves, and a teaspoon of burdock root in a glass container.
  2. Pour 300 ml of boiling water over the raw materials, close the jar with a lid.
  3. Leave for an hour, then filter.
  4. Take three times a day 30 minutes before meals. A single dosage is two tablespoons. The course of treatment is two weeks.

Photo gallery: medicinal plants for nephrocalcinosis

Corn silk has a diuretic effect Birch leaves eliminate inflammatory processes in the kidneys
Flax seeds improve kidney function and also reduce pain Burdock root enhances kidney excretory function
Rose hips improve blood circulation in the kidneys and increase their filtration function

Treatment prognosis and possible complications

With timely diagnosis and correct treatment, the outcome of the disease is often positive: nephrocalcinosis can be defeated. If the pathology is in an advanced stage, the prognosis is very sad: renal failure develops, in which the kidneys completely lose their excretory and filtration functions.


There are only two ways out of this situation: lifelong use of hemodialysis or organ transplantation.

When renal failure develops, replacement therapy is used - hemodialysis

Prevention

  • Rules for successful prevention of nephrocalcinosis:
  • watch your diet - eat healthy and high-quality foods, do not overuse spicy and salty foods;
  • drink clean water;
  • lead an active lifestyle - physical activity improves blood circulation in the kidneys, which prevents congestion;
  • complete the treatment of all infectious and inflammatory diseases in the body;
  • give up bad habits - drinking alcohol and smoking;
  • undergo regular preventive medical examinations;

Use antibacterial agents and other medications wisely.

It is impossible to completely protect yourself from nephrocalcinosis. However, if you follow simple rules of prevention, the risk of developing pathology is reduced. If the diagnosis has already been made, you should not lose heart. Contact a competent specialist and follow his instructions.

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