The instructions for use recommend taking the drug Aspirin UPSA to block pain and lower body temperature in infectious or inflammatory diseases. The medicine belongs to the group of non-steroidal anti-inflammatory drugs.

The drug has a pronounced analgesic, anti-inflammatory and antipyretic effect. What Aspirin UPSA helps with, information on prices, analogues and patient reviews will also be presented in the article.

Aspirin UPSA is produced in the form of flat, white, effervescent tablets (4 tablets per strip). 1 tablet contains the active substance - Acetylsalicylic acid in the amount of 500 mg.

Auxiliary components are anhydrous sodium carbonate, anhydrous citric acid, anhydrous sodium citrate, sodium bicarbonate, crospovidone, aspartame, natural orange flavor, povidone.

The box of tablets contains instructions for use with a description of its administration.

Pharmacological properties

The instructions for Aspirin UPSA state that this drug has anti-inflammatory, analgesic and antipyretic effects. Aspirin UPSA effervescent has several advantages compared to traditional acetylsalicylic acid tablets: the active substance is absorbed more quickly and in greater volume when taking soluble tablets.

Also, in agreement with reviews of Aspirin UPSA effervescent, the drug in this form is better tolerated by patients. The instructions for this drug state that the drug minimizes platelet aggregation and reduces thrombus formation, while the therapeutic antiplatelet effect persists for a week after a single dose of the tablet.

Indications for use

What does Aspirin UPSA help with? Tablets are prescribed for:

Moderate or mild pain of various origins, including headache and toothache, muscle and joint pain, neuralgia, migraine, thoracic radicular syndrome, algodismenorrhea.
Fever due to colds or other infectious and inflammatory diseases.

Medicine Aspirin UPSA: instructions for use

The instructions for the drug state that effervescent tablets can be used by adult patients and children over 15 years of age. The drug is intended for oral use only. Aspirin UPSA is usually used one tablet no more than six times a day (the interval between taking tablets should be 4-6 hours).

Before using the drug, the tablet is dissolved in 200 ml of water at room temperature (you can also dissolve the drug in juice). At the initial stage of the disease, accompanied by high fever and severe pain, you can take two tablets of the drug at a time, but the total number of tablets taken during the day should not exceed 6 pieces. Elderly people should take no more than 4 tablets per day.

When using Aspirin UPSA tablets as an antipyretic, the course of treatment should not exceed three days; if at the end of this period the patient’s condition does not improve, it is necessary to urgently consult a doctor to prescribe adequate treatment. If the drug is used as an analgesic, the duration of treatment should not exceed five days.

Contraindications

Aspirin UPSA instructions for use prohibit taking it for the following pathologies:

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding.
Portal hypertension.
Aspirin-induced asthma.
Dissecting aortic aneurysm.
Phenylketonuria.
Hemorrhagic diathesis, including hemophilia, telangiectasia, von Willebrand disease, thrombocytopenia, hypoprothrombinemia, thrombocytopenic purpura.
Glucose-6-phosphate dehydrogenase deficiency.
Hypersensitivity to the components of Aspirin UPSA or other non-steroidal anti-inflammatory drugs.
Severe dysfunction of the liver and kidneys.
Vitamin K deficiency.

The drug is allowed to be taken only in the second trimester of pregnancy; if taken during lactation, it is recommended to stop breastfeeding. Aspirin UPSA is not used in children under 15 years of age due to the risk of developing Reye's syndrome.

The medicine should be taken with caution in case of urate nephrolithiasis, hyperuricemia, decompensated heart failure and a history of gastric and duodenal ulcers. When using Aspirin UPSA, it should be taken into account that it can cause an acute attack of gout if there is an existing predisposition.

(500 mg); excipients: anhydrous sodium carbonate, anhydrous citric acid, anhydrous sodium citrate, sodium bicarbonate, crospovidone, aspartame, natural orange flavor, povidone.

With vitamin C: acetylsalicylic acid (330 mg), ascorbic acid (200 mg). Excipients: glycine, sodium benzoate, anhydrous citric acid, monosodium carbonate, polyvinlpyrrolidone.

Package

4 effervescent tablets in a strip of aluminum foil, coated on the inside with polyethylene. 4 or 25 strips along with instructions for use in a cardboard pack.

With vitamin C: 10 tablets per tube. One or two tubes in a cardboard box

Manufacturer

UPSA Laboratories (France).

Pharmacological group

Non-narcotic analgesics/antiplatelet agents, non-steroidal anti-inflammatory drugs (NSAIDs), salicylic acid derivatives + vitamin.

Pharmacological action

It has anti-inflammatory, analgesic and antipyretic effects associated with the suppression of cyclooxygenase 1 and 2, which regulate the synthesis of prostaglandins. Reduces platelet aggregation, adhesiveness and thrombus formation by suppressing the synthesis of thromboxane A2 in platelets, while the antiplatelet effect persists for a week after a single dose.

The advantage of the soluble form of the drug compared to the traditional one is more complete and rapid absorption of the active substance and its better tolerability.

Pharmacokinetics

Aspirin UPSA is absorbed more quickly than regular aspirin. The maximum concentration of acetylsalicylic acid is achieved in 20 minutes. The plasma half-life ranges from 15 to 30 minutes. Acetylsalicylic acid undergoes hydrolysis in plasma to form salicylic acid. Salicylate is largely bound to plasma proteins. Urinary excretion increases with urine pH. The half-life of salicylic acid ranges from 3 to 9 hours and increases with the dose of the drug taken.

Indications

Moderate or mild pain syndrome in adults of various origins: headache (including those associated with alcohol withdrawal syndrome), toothache, migraine, neuralgia, thoracic radicular syndrome, muscle and joint pain, pain during menstruation.
Increased body temperature during colds and other infectious and inflammatory diseases (in adults and children over 15 years of age).

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding;
Portal hypertension;
"Aspirin" asthma;
Dissecting aortic aneurysm;
Phenylketonuria;
Hemorrhagic diathesis, including hemophilia, telangiectasia, von Willebrand disease, thrombocytopenia, hypoprothrombinemia, thrombocytopenic purpura;
Glucose-6-phosphate dehydrogenase deficiency;
Hypersensitivity to the components of Aspirin UPSA or other non-steroidal anti-inflammatory drugs;
Severe dysfunction of the liver and kidneys;
Vitamin K deficiency.

with caution with urate nephrolithiasis, hyperuricemia, decompensated heart failure and a history of gastric and duodenal ulcers. When using aspirin, it should be taken into account that it can cause an acute attack of gout if there is an existing predisposition.

Directions for use and doses

The dosage and schedule of administration are determined by the attending physician, since everything here depends on the age and condition of the patient.

Effervescent tablets must first be dissolved in 100-200 mg of boiled water at room temperature. It is advisable to take the drug after meals.

For severe pain, you can take 400-800 mg of acetylsalicylic acid 2-3 times a day (but not more than 6 g per day). Small doses are used as an antiplatelet agent - 50, 75, 100, 300 or 325 mg of the active substance. For fever, it is recommended to take 0.5-1 g of acetylsalicylic acid per day (if necessary, the dose can be increased to 3 g).

The duration of treatment should not exceed 14 days.

Side effect

Skin rash, “aspirin triad”, bronchospasm and Quincke’s edema;
Renal dysfunction;
Nosebleeds, increased clotting time, bleeding gums;
Nausea, loss of appetite, vomiting, gastrointestinal bleeding, pain in the epigastric region, diarrhea;
Thrombocytopenia, leukopenia, anemia, hyperbilirubinemia.

If undesirable effects occur, Aspirin UPSA should be discontinued.

Overdose

Beware of intoxication in the elderly and especially in young children (therapeutic overdose or accidental intoxication, often found in very young children), which can result in death.

Clinical symptoms- with moderate intoxication, tinnitus is possible, decreased hearing acuity, headaches, dizziness, nausea are a sign of an overdose. These phenomena are eliminated when the dose is reduced. In severe intoxication - hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiovascular collapse, respiratory failure, high hypoglycemia.

Treatment- rapid removal of the drug by gastric lavage. immediate hospitalization in a specialized institution. Control of acid-base balance. Forced alkaline diuresis, hemodialysis or peritoneal dialysis if necessary.

Drug interactions

Combinations with methotrexate are contraindicated, especially at high doses (this increases toxicity); with oral anticoagulants at high doses the risk of bleeding increases.

Undesirable combinations - with oral anticoagulants (at low doses the risk of bleeding increases), with ticlopidine (the risk of bleeding increases), with uricosuric drugs (a possible decrease in the uricosuric effect), with other anti-inflammatory drugs.

Combinations that require precautions: with antidiabetic agents (in particular, hypoglycemic sulfamides) - the hypoglycemic effect increases; with antacids - intervals between doses of antacids and salicylic drugs should be observed (2 hours); with diuretics - with high doses of salicylic drugs, it is necessary to maintain a sufficient supply of water, monitor kidney function at the beginning of treatment due to possible acute renal failure in a dehydrated patient; with corticoids (glucocorticoids) - a decrease in salicylaemia is possible during treatment with corticoids and there is a risk of salicylic overdose after its cessation.

Pregnancy and lactation

The drug is contraindicated during pregnancy in the 1st and 3rd trimester. In the second trimester of pregnancy, a single dose of the drug in recommended doses is possible only if the expected benefit to the mother exceeds the potential risk to the fetus. If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Special instructions

The drug may promote bleeding and also increase the length of menstruation. Aspirin increases the risk of bleeding during surgery.

In children, when prescribing the drug, it is necessary to take into account age and body weight.

When planning your daily diet on a sodium-free diet, it is important to take into account that each tablet of UPSA aspirin with vitamin C contains approximately 485 mg of sodium.

In animals, a teratogenic effect of the drug is observed.

Storage conditions

In a dry place, out of reach of children, at a temperature not exceeding 30°C. Shelf life - 3 years.

How to take aspirin oops for a hangover. International nonproprietary name

Instructions

According to the instructions, Aspirin UPSA should be taken orally after meals, after dissolving the tablets in 100–200 ml of water. A single dose of the drug can range from 0.25 mg to 1 g. It is taken 3 or 4 times a day. The maximum dose of the drug is 6 g per day. Depending on the indications, taking Aspirin UPSA can be a single dose or last for several months.

For elevated body temperature or pain, the dose of Aspirin UPSA is 0.5–1 g per day. It must be divided into 3 doses during the day. The maximum duration of treatment is no more than 2 weeks. For acute rheumatism, the dose of the drug is determined based on the calculation of 100 mg per 1 kg of body weight and is drunk during the day in 5-6 doses. In order to improve the rheological properties of blood, Aspirin UPSA is prescribed in a daily dose of 0.15–0.25 g for several months. To suppress platelet aggregation, the drug is also taken for a long time at a dose of 300–325 mg per day.

The dose of Aspirin UPSA for the treatment of cardiovascular diseases can vary from 40 to 325 mg. For myocardial infarction and secondary prevention of myocardial infarction, the average dose of the drug is 160 mg once a day, however, depending on the patient’s condition, it can be adjusted down or up. Patients with dynamic cerebrovascular accidents and cerebral thromboembolism are prescribed 325 mg of Aspirin UPSA per day, gradually increasing the daily dose to 1 g. In order to prevent thrombosis and occlusion of the aortic shunt, the drug is taken at a dose of 325 mg 3 times a day.

The duration of use of Aspirin UPSA without consulting a doctor should be no more than 3 days for elevated body temperature and no more than 7 days for pain. When carrying out longer-term treatment, it is necessary to monitor blood counts, as well as regular stool testing for occult blood.

“Aspirin UPSA” should not be taken in case of hypersensitivity to acetylsalicylic acid, in the first and third trimesters of pregnancy and during breastfeeding, as well as when treating children. In addition, the drug is contraindicated in renal and liver failure, deficiency of vitamin K and glucose-6-phosphate dehydrogenase, gastrointestinal bleeding or exacerbation of erosive and ulcerative lesions of the gastrointestinal tract, hemorrhagic diathesis, portal hypertension and aortic dissection.

Video on the topic

Aspirin comes in several forms. Which aspirin to choose - effervescent or tablet - is the patient’s right. There is no evidence that the effervescent version acts faster, although it is often combined with other medicinal substances that do relieve the condition.

Effervescent aspirin is more convenient to use because there is no need to take a tablet. Some people, due to their individual characteristics, cannot swallow a pill. Effervescent forms are also suitable for patients who are forced to occupy a horizontal position, and therefore the tablet simply will not pass through the esophagus.

Which is better

Any form of aspirin has a negative effect on the gastric mucosa if taken before meals. Aspirin should always be taken after meals. Although effervescent tablets do not cause pinpoint ulcers. This can happen if the tablet sticks to the mucous membrane.
Effervescent aspirin usually tastes good, which can make the treatment process easier. In cases where the medicine is taken occasionally, you can get by with regular tablet aspirin. If you need to take it regularly, then you should use effervescent forms.

It is easier to dose the tablets by dividing them along the cut line; this does not affect the short-term storage of the remaining tablets. Effervescent forms may become unusable within a few hours after opening the individual packaging.

Tablet aspirin has many more release forms, which allows you to accurately dose the amount of the drug. Thus, Aspirin-Cardio is available in dosages from 75 to 325 mg. A quarter of a regular tablet is 125 mg. It's not always easy to split a tablet into 4 parts, let alone measure out 75 mg. The tablet crumbles and breaks into fragments.

Types of aspirin

If your doctor has prescribed you a specific form of aspirin, for example Aspirin-Cardio or Aspirin-C (with vitamin C), then this form will be the most optimal. If you want to take aspirin of a different brand, or there is a medicine in a different form of release in your medicine cabinet, you should tell your doctor about it. Most often, the issue is resolved in favor of the patient’s wishes, since in any case the active substance is always the same - acetylsalicylic acid.

Latin name: ASPIRINE UPSA
ATX code: N02B A01
Active ingredient: acetylsalicylic acid
Manufacturer: Bristol-Myers Squibb (France)
Conditions for dispensing from a pharmacy: Over the counter

Aspirin Upsa is a non-steroidal anti-inflammatory drug with a broad spectrum of action. Designed to relieve various types of pain, febrile conditions, and elevated temperatures. In the CIS countries it is sold under the name Upsarin Upsa.

Indications for use

Due to the properties of acetylsalicylic acid, the medicine has analgesic, anti-inflammatory, and antipyretic effects. Aspirin Upsa quickly helps with:

Pain of various etiologies
Inflammatory processes
Feverish conditions, high temperature
Colds and infectious diseases.

The high effectiveness of Aspirin Upsa is also due to the form of the tablets. Their use in dissolved form protects the gastrointestinal tract from damage by acetylsalicylic acid, since in this form it cannot return to its original (undissolved) form after interaction with the acidic gastric environment, and therefore does not settle on the walls of the organ. Therefore, the drug not only acts quickly, but is also more gently tolerated compared to conventional pills.

Composition of the drug

The active ingredient that determines the properties of the drug is acetylsalicylic acid, content - 500 mg.

Auxiliary ingredients that determine the structure and properties of the therapeutic agent are citric acid, sodium compounds (carbonate and citrate), orange flavoring, aspartame, croslovidone, and other components.

Medicinal properties

Aspirin in effervescent tablets is absorbed faster than a similar drug, but in its usual form. The highest concentration in the blood is formed 10-40 minutes after administration. The active substance is hydrolyzed to form salicylic acid, which also has a therapeutic effect. Both components quickly spread throughout the body, cross the placental barrier, and are excreted in milk.

Acetylsalicylic acid is converted in the liver, its metabolites are excreted in the urine.

Release forms

Average price – 187 rubles.

Aspirin is produced in the form of effervescent tablets. The pills are flat-cylindrical in shape, have a chamfer and a dividing line. When the tablets dissolve, a reaction occurs that releases carbon dioxide.

The product is packaged in strips of 4 pills, in a cardboard package - 4 strips, an accompanying summary.

Directions for use

Aspirin Upsa instructions for use advise use only from 15 years of age. The effervescent pill is dissolved in 200 ml of boiled water immediately before use. The highest permissible daily dose for people whose weight is more than 50 kg is 3 g (or 6 tablets).

Usually one effervescent tablet is taken at a time; it can be taken again only after 4 hours. In acute conditions (severe pain or high temperature), it is allowed to take two pills at a time.
For older people, the daily dose is 2 g of the substance (or 4 tablets).
For patients suffering from kidney or liver dysfunction, the dosage of Aspirin Upsa is reduced or the time interval between doses is increased.

In the absence of medical prescriptions and self-administration of the medicine, the duration of the course of Aspirin Upsa as an antipyretic should not last more than 3 days, and as an analgesic - not exceed 5.

During pregnancy and pregnancy

Preparations with acetylsalicylic acid cannot be used during these periods, especially for women in the 1st or 2nd trimester, due to the high risk of pathologies in the fetus (cleft palate, abnormalities of heart formation). In case of urgent need, doses should be as small as possible, and use should be short-term, carried out under the supervision and responsibility of a doctor.

In the 3rd trimester, acid is categorically contraindicated, as it can contribute to post-term pregnancy, weak labor, and impaired renal function in the child, leading to the development of failure.

In addition, acid can cause heavy and prolonged bleeding in the mother or fetus. Moreover, small doses of aspirin also cause them. Large doses of acid used at the end of pregnancy lead to the development of intracranial bleeding. Premature babies are especially susceptible to this.

Breastfeeding women should also give up Aspirin Upsa, since acetylsalicylic acid has the ability to penetrate into milk.

Contraindications

Aspirin should not be taken if there is individual hypersensitivity to the active or auxiliary components, as well as with:

Children's age (up to 15 years)
Bronchial asthma
Heart failure
Predisposition to bleeding
Acute form of peptic ulcer and duodenal ulcer
Severe pathologies of the kidneys and liver
Portal hypertension
Hemophilia
Aspirin asthma
Hypovitaminosis K
Low level of gastric acidity
Low calcium content
Dissecting aortic aneurysm
Pregnancy and breastfeeding.

Precautions

With a long course of Aspirin Upsa, it is necessary to systematically do blood and stool tests and check the condition of the liver.

In patients with gout, the drug may cause an exacerbation due to the ability of acetylsalicylic acid to inhibit urinary excretion.
For patients undergoing surgery, the drug should be discontinued to reduce bleeding during and after surgery.
People who control their salt intake should remember that it is present in Aspirin Upsa.

Cross-drug interactions

If there is a need for other medications, then the course of Aspirin Upsa should be carried out with caution, since acetylsalicylic acid reacts with their components and distorts the properties. Therefore, it is imperative to inform your doctor about the medications you are taking.

Aspirin enhances the properties of antidiabetic and anticonvulsant drugs, diuretics.
When combined with alcohol-containing drugs or alcohol, damage to the mucous membranes of the gastrointestinal tract and the intensity and duration of internal bleeding increases.
Aspirin should not be used with oral anticoagulants, as the effect of the latter is weakened and the risk of bleeding increases. If use is necessary, it is necessary to constantly check the level of blood clotting.
Preparations containing magnesium, aluminum, and calcium salts accelerate the elimination of salicylates.

Side effects

Manifestations of allergies - skin and respiratory (up to angioedema or bronchospasm)
Aspirin triad
Abnormal bowel movements, abdominal pain, internal bleeding, loss of appetite
Kidney damage
Bleeding gums, nosebleeds, thinning and bleeding disorders.

If suspicious signs appear after taking Aspirin Upsa, it should be discontinued and consult a doctor.

Overdose

An overdose condition can develop when accidentally consuming a large number of Aspirin Upsa tablets or over a long course. Intoxication can also develop in elderly and senile people.

Depending on the concentration of the drug, it can be asymptomatic (with prolonged use of the prescribed doses) and manifest itself acutely after taking large doses of Aspirin Upsa. Severe overdose can be fatal.

Intoxication may manifest itself:

Headaches and dizziness
Confusion and imbalance
Nausea, tinnitus, sweating, hearing loss.

For moderate and severe conditions:

Rapid breathing, hyperventilation
Non-cardiogenic pulmonary edema
Stopping breathing
Changes in heart rate
Dehydration
Bleeding in the gastrointestinal tract
Drowsiness, lethargy, central nervous system depression, convulsions, coma.

An overdose of Aspirin Upsa is especially dangerous for children, so if symptoms of salicylate poisoning occur, you should not hesitate, you must call emergency help as soon as possible.

Conditions and shelf life

The product is suitable for use for 3 years from the date of issue. To avoid loss of therapeutic properties, it should be protected from heat, light and high humidity. Store at temperatures up to 25°C, keep out of reach of children.

Analogues

Finding a product containing acetylsalicylic acid is not a problem today. But given its pharmacological characteristics, replacement must be done with the help of a doctor.

Bayer (Germany)

Average price: 258 rub.

The product contains 400 mg of active substance, enriched with vitamin C (240 mg). Additional components are ingredients that form the structure and solubility of the drug. The drug is available in the form of large white tablets for preparing a drink; on one side there is an imprint of the concern's logo in the form of a cross.

The product is taken one pill dissolved in water, the maximum permissible single dose is 2 tablets, repeated after four hours.

Advantages:

Excellent quality
Productivity.

Flaws:

An allergic reaction is possible.

Acetylsalicylic acid

Aspirin UPSA:: Dosage form

tablets, tablets [for children], enteric-coated tablets, film-coated tablets, effervescent tablets

Aspirin UPSA:: Pharmacological action

NSAIDs; has anti-inflammatory, analgesic and antipyretic effects associated with indiscriminate inhibition of the activity of COX1 and COX2, which regulate the synthesis of Pg. As a result, Pg is not formed, which ensures the formation of edema and hyperalgesia. A decrease in Pg content (mainly E1) in the thermoregulation center leads to a decrease in body temperature due to dilation of skin vessels and increased sweating. The analgesic effect is due to both central and peripheral effects. Reduces platelet aggregation, adhesion and thrombus formation by suppressing the synthesis of thromboxane A2 in platelets. The antiplatelet effect persists for 7 days after a single dose (more pronounced in men than in women). Reduces mortality and the risk of myocardial infarction in unstable angina. Effective in the primary prevention of cardiovascular diseases, especially myocardial infarction in men over 40 years of age, and in the secondary prevention of myocardial infarction. In a daily dose of 6 g or more, it suppresses prothrombin synthesis in the liver and increases prothrombin time. Increases fibrinolytic activity of plasma and reduces the concentration of vitamin K-dependent coagulation factors (II, VII, IX, X). Increases the incidence of hemorrhagic complications during surgical interventions, increases the risk of bleeding during anticoagulant therapy. Stimulates the excretion of uric acid (impairs its reabsorption in the renal tubules), but in high doses. Blockade of COX1 in the gastric mucosa leads to inhibition of gastroprotective Pg, which can cause ulceration of the mucous membrane and subsequent bleeding. Dosage forms containing buffer substances, enteric coating, as well as special “effervescent” forms of tablets have a lesser irritating effect on the gastrointestinal mucosa.

Aspirin UPSA:: Indications

Rheumatism, rheumatoid arthritis, infectious-allergic myocarditis, pericarditis, rheumatic chorea - not currently used. Feverish syndrome in infectious and inflammatory diseases. Pain syndrome (of various origins): headache (including those associated with alcohol withdrawal syndrome), migraine, toothache, neuralgia, lumbago, thoracic radicular syndrome, myalgia, arthralgia, algodismenorrhea. As an antiplatelet drug (doses up to 300 mg/day): IHD, the presence of several risk factors for IHD, silent myocardial ischemia, unstable angina, myocardial infarction (to reduce the risk of recurrent myocardial infarction and death after myocardial infarction), repeated transient cerebral ischemia and ischemic stroke in men, heart valve replacement (prevention and treatment of thromboembolism), balloon coronary angioplasty and stent installation (reducing the risk of re-stenosis and treatment of secondary coronary artery dissection), for non-atherosclerotic lesions of the coronary artery (Kawasaki disease), aortoarteritis (Takayasu disease), valvular mitral heart defects and atrial fibrillation, mitral valve prolapse (prevention of thromboembolism), recurrent pulmonary embolism, pulmonary infarction, acute thrombophlebitis, Dressler's syndrome. In clinical immunology and allergology: in gradually increasing doses for long-term “aspirin” desensitization and the formation of stable tolerance to NSAIDs in patients with “aspirin” asthma and the “aspirin triad”.

Aspirin UPSA:: Contraindications

Hypersensitivity; erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding; “aspirin” triad (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to ASA and pyrazolone-type drugs); hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura); dissecting aortic aneurysm, portal hypertension; vitamin K deficiency; liver/renal failure; pregnancy (I and III trimesters), lactation period; deficiency of glucose-6-phosphate dehydrogenase, childhood (under 15 years of age - the risk of developing Reye's syndrome in children with hyperthermia due to viral diseases). With caution. Hyperuricemia, urate nephrourolithiasis, gout, liver disease, peptic ulcer of the stomach and/or duodenum (history), decompensated CHF.

Aspirin UPSA:: Side effects

Aspirin can cause side effects such as nausea, loss of appetite, gastralgia, diarrhea; allergic reactions (skin rash, angioedema, bronchospasm); impaired liver and/or kidney function; thrombocytopenia, anemia, leukopenia, Reye's syndrome (encephalopathy and acute fatty liver with rapid development of liver failure), the formation of “aspirin” asthma and the “aspirin triad” based on the hapten mechanism (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and ASA intolerance and drugs of the pyrazolone series). With long-term use - dizziness, headache, vomiting, erosive and ulcerative lesions of the gastrointestinal tract, hypocoagulation, bleeding (including in the gastrointestinal tract); visual impairment, decreased hearing acuity, tinnitus, bronchospasm, interstitial nephritis, prerenal azotemia with increased creatinine in the blood and hypercalcemia, papillary necrosis, acute renal failure, nephrotic syndrome, aseptic meningitis, increased symptoms of CHF, edema, increased activity of the liver "transaminases. Overdose. Symptoms (single dose less than 150 mg/kg - acute poisoning is considered mild, 150-300 mg/kg - moderate, more than 300 mg/kg - severe): salicylic syndrome (nausea, vomiting, tinnitus, blurred vision, dizziness, severe headache, general malaise, fever - a poor prognostic sign in adults). Severe poisoning - hyperventilation of the lungs of central origin, respiratory alkalosis, metabolic acidosis, confusion, drowsiness, collapse, convulsions, anuria, bleeding. Initially, central hyperventilation of the lungs leads to respiratory alkalosis - shortness of breath, suffocation, cyanosis, cold sticky sweat; with increasing intoxication, respiratory paralysis and uncoupling of oxidative phosphorylation increase, causing respiratory acidosis. In chronic overdose, the concentration determined in plasma does not correlate well with the severity of intoxication. The greatest risk of developing chronic intoxication is observed in elderly people when taking more than 100 mg/kg/day for several days. In children and elderly patients, the initial signs of salicylicism are not always noticeable, so it is advisable to periodically determine the concentration of salicylates in the blood: a level above 70 mg% indicates moderate or severe poisoning; above 100 mg% - extremely severe, prognostically unfavorable. Moderate poisoning requires hospitalization for 24 hours. Treatment: provocation of vomiting, administration of activated carbon and laxatives, constant monitoring of CBS and electrolyte balance; depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate solution or sodium lactate. Increasing reserve alkalinity enhances the excretion of ASA due to alkalinization of urine. Alkalinization of urine is indicated when the level of salicylates is above 40 mg% and is provided by intravenous infusion of sodium bicarbonate (88 mEq in 1 liter of 5% dextrose solution, at a rate of 10-15 ml/h/kg); restoration of bcc and induction of diuresis is achieved by administering sodium bicarbonate in the same doses and dilution, which is repeated 2-3 times. Caution should be exercised in elderly patients in whom intensive fluid infusion may lead to pulmonary edema. The use of acetazolamide for alkalinization of urine is not recommended (it can cause acidemia and enhance the toxic effect of salicylates). Hemodialysis is indicated when the level of salicylates is more than 100-130 mg%, in patients with chronic poisoning - 40 mg% and lower if indicated (refractory acidosis, progressive deterioration, severe damage to the central nervous system, pulmonary edema and renal failure). For pulmonary edema - mechanical ventilation with an oxygen-enriched mixture.

Aspirin UPSA:: Method of administration and dosage

Soluble tablets: orally, after dissolving in a small amount of water, 400-800 mg 2-3 times a day (no more than 6 g). For acute rheumatism - 100 mg/kg/day in 5-6 divided doses. Tablets containing ASA in doses over 325 mg (400-500 mg) are designed for use as an analgesic and anti-inflammatory drug; in doses of 50-75-100-300-325 mg - in adults, mainly as an antiplatelet drug. Orally, for fever and pain in adults - 0.5-1 g/day (up to 3 g), divided into 3 doses. The duration of treatment should not exceed 2 weeks. Effervescent tablets are dissolved in 100-200 ml of water and taken orally, after meals, a single dose is 0.25-1 g, taken 3-4 times a day. The duration of treatment ranges from a single dose to a multi-month course. To improve the rheological properties of blood - 0.15-0.25 g/day for several months. For myocardial infarction, as well as for secondary prevention in patients who have had a myocardial infarction, 40-325 mg once a day (usually 160 mg). As an inhibitor of platelet aggregation - 300-325 mg/day for a long time. For dynamic cerebrovascular accidents in men, cerebral thromboembolism - 325 mg/day with a gradual increase to a maximum of 1 g/day, for the prevention of relapses - 125-300 mg/day. For the prevention of thrombosis or occlusion of the aortic shunt - 325 mg every 7 hours through an intranasally inserted gastric tube, then orally - 325 mg 3 times a day (usually in combination with dipyridamole, which is discontinued after a week, continuing long-term treatment with ASA). For active rheumatism, it was prescribed (not currently prescribed) in a daily dose of 5-8 g for adults and 100-125 mg/kg for adolescents (15-18 years); frequency of use - 4-5 times a day. After 1-2 weeks of treatment for children, the dose is reduced to 60-70 mg/kg/day, treatment for adults is continued at the same dose; Duration of treatment - up to 6 weeks. Cancellation is carried out gradually over 1-2 weeks.

Aspirin UPSA:: Special instructions

The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic drug and more than 3 days as an antipyretic. Currently, the use of ASA as an anti-inflammatory drug in a daily dose of 5-8 g is limited due to the high likelihood of developing side effects from the gastrointestinal tract (NSAID gastropathy). Before surgery, to reduce bleeding during surgery and in the postoperative period, you should stop taking salicylates 5-7 days in advance and notify the doctor. During long-term therapy, it is necessary to conduct a complete blood count and stool examination for occult blood. Children should not be prescribed drugs containing ASA, since in the case of a viral infection they can increase the risk of Reye's syndrome. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, and liver enlargement. Prescribing tablets after meals, thoroughly crushing them, using tablets with buffer additives or coated with a special enteric coating, as well as the simultaneous use of drugs that neutralize the acidity of gastric juice, reduce the irritant effect on the gastrointestinal tract. Has a teratogenic effect; when used in the first trimester, it leads to the development of cleft palate; in the third trimester it causes inhibition of labor (inhibition of Pg synthesis), premature closure of the ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the “lesser” circulation. It is excreted in breast milk, which increases the risk of bleeding in the baby due to impaired platelet function. ASA, even in small doses, reduces the excretion of uric acid from the body, which can cause the development of an acute attack of gout in predisposed patients. During the treatment period, you should refrain from taking ethanol.

Aspirin UPSA:: Interaction

Increases the toxicity of methotrexate, reducing its renal clearance, the effects of other NSAIDs, narcotic analgesics, oral hypoglycemic drugs, reserpine, heparin, indirect anticoagulants, thrombolytics and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole), T3; reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), antihypertensive drugs, diuretics (spironolactone, furosemide). GCS, ethanol and ethanol-containing drugs increase the damaging effect on the gastrointestinal mucosa and increase the risk of gastrointestinal bleeding. Increases the concentration of digoxin, barbiturates, Li+ salts in plasma. Antacids containing Mg2+ and/or Al3+ slow down and impair the absorption of ASA. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.