Duphaston analogues are cheap. Indications for use

It's no secret that every year the state environment significantly deteriorates, which has a detrimental effect on people's health. Without the help of medications, many women cannot conceive and bear a child. But science does not stand still: many drugs are appearing that not only increase the likelihood of a desired pregnancy, but also normalize women’s health. One of these medicinal “helpers” for the fair sex is Duphaston. But not only this drug helps restore hormonal balance female body and allows you to make your dream of having a baby come true. The doctor can also prescribe an analogue of Duphaston, and more than one. But let’s try to figure it out which one is better.

Why is Duphaston so good?

Before considering which drug can be a worthy alternative to this medicine, you should understand what properties it has and how it acts on a woman’s body.

So, dydrogesterone, which is the basis of the drug, according to molecular structure, pharmacological and chemical properties close to natural progesterone. It is the deficiency of this hormone that can deprive a woman of the joy of motherhood. Despite the fact that it is a testosterone derivative, side effects does not have a hormone. It is worth noting that this characteristic is a huge advantage of the medicine. The same cannot be said about many synthetic progestogens, which are necessary components of replacement hormone therapy. Among other things, the drug does not affect the metabolism of carbohydrates and the functioning of the liver, its effect does not affect the processes of ovulation and metabolism.

Pharmacokinetics

A special feature of the drug "Duphaston" is that it quickly comes from gastrointestinal tract V bloodstream. The maximum concentration in the blood after taking the tablets is observed after 2 hours. Further, 97% of dydrogesterone binds to proteins and is hydroxylated in liver cells.

Results clinical trials confirm that about 64% of the dose of dydrogesterone is excreted naturally, with urine. Thanks to this, it becomes possible to determine the endogenous level of progesterone. The instructions will help you obtain more specific information about the pharmacokinetics of the drug Duphaston.

Analogues of the drug do not have the properties mentioned above.

Indications for use

Before considering medications that can replace the drug Duphaston, you should understand in what cases women's issues he is appointed.

Most often, doctors recommend taking the drug Duphaston to women who have been diagnosed with progesterone deficiency. The low level of this particular hormone in a woman’s body is the cause of many troubles, such as the threat of fetal loss, menstrual irregularities, dysmenorrhea, premenstrual syndrome, infertility, secondary amenorrhea, dysfunctional uterine bleeding.

For all of the above ailments and conditions, doctors do not prohibit taking an analogue of Duphaston tablets, but if the budget allows, they recommend using the original drug.

How can I replace Duphaston?

Today, the most famous and most often used drug, which can fully replace the drug Duphaston, is Utrozhestan. But, fortunately, scientists did not stop at developing only this medicine. Therefore, today a woman who wants to conceive and safely carry a baby can purchase the most suitable option from a wide range of drugs. Of course, it is worth noting that this choice must be made entirely by the doctor, taking into account individual characteristics patients. But situations in life are different, therefore, after consulting with a pharmacist, you can independently purchase a worthy analogue of Duphaston.

The drug "Urozhestan"

The drug "Utrozhestan" is produced on the basis of plant raw materials diogenin - a Mexican plant, better known as wild yam. It has an antiandrogenic effect and neutralizes the effects of oxytocin, which causes uterine hypertonicity. Also this Russian analogue"Duphaston" is beneficial for pregnant women sedative effect, does not predispose to weight gain and does not affect the removal of fluid from the body.

Advantages and disadvantages of the drug "Utrozhestan"

A distinctive negative characteristic of this drug is a significant number of side effects, which are not observed when using Duphaston tablets. This may include increased fatigue, dizziness, drowsiness, general malaise, confusion and other reactions.

But it is worth noting that the above side effects fully compensate for the advantageous characteristics of the drug. Thus, the medicine “Utrozhestan” can be used both orally and intravaginally. This allows the drug to be prescribed not only to pregnant women with early toxicosis, but also to achieve maximum therapeutic results in the development of other pathologies in expectant mothers.

The benefits of the medicine include its cost. After all, this analogue of Duphaston is an order of magnitude cheaper than the original. But it is worth remembering that it is strictly prohibited to independently replace the prescribed medicine. Therefore, before you buy this more affordable medication, you should consult your doctor, especially if we're talking about about maintaining the desired pregnancy.

Dydrogesterone product

Like the drug Duphaston, its analogs replenish the deficiency of progesterone in a woman’s body. In particular, the drug "Dydrogesterone" helps maintain the beneficial effect of estrogen on lipid profile blood. The active ingredient of the drug does not affect coagulation parameters, as well as carbohydrate metabolism and liver function. In addition, the advantages of the drug include the absence of androgenic, estrogenic, thermogenic, corticoid or anabolic activity.

Today, Dydrogesterone is a good and affordable Russian analogue of Duphaston. This synthetic progestogen is indicated for endogenous progesterone deficiency.

Remedy "Prajisan"

This modern analogue"Duphaston" is hormonal agent with progesterone. It is used in the treatment of long-term infertility, as well as luteal phase deficiency. Effective when various violations menstrual cycle, premenopause, fibrocystic mastopathy and other ailments.

Since the drug has a wider spectrum of action than Duphaston, it is used only before pregnancy. Exceptions are cases when the benefit to the mother's body exceeds possible risk negative impact for the fruit.

Which analogue is better?

Only doctors have the right to talk about what medicine can replace Duphaston. Analogs of the drug are selected by a professional, taking into account all the individual characteristics of the patient and the complexity of her disease. Self-appointment medications in this group can harm the health of both the mother and the baby, and sometimes cause spontaneous abortion (if the drug is abruptly discontinued).

It's no secret that every year the state of the environment is deteriorating significantly, which has a detrimental effect on people's health. Without the help of medications, many women cannot conceive and bear a child. But science does not stand still: many drugs are appearing that not only increase the likelihood of a desired pregnancy, but also normalize women’s health. One of these medicinal “helpers” for the fair sex is Duphaston. But not only this drug helps restore the hormonal balance of the female body and makes the dream of having a baby come true. The doctor can also prescribe an analogue of Duphaston, and more than one. But let’s try to figure it out which one is better.

Why is Duphaston so good?

Before considering which drug can be a worthy alternative to this medicine, you should understand what properties it has and how it acts on a woman’s body.

So, dydrogesterone, which is the basis of the drug, is close in molecular structure, pharmacological and chemical properties to natural progesterone. It is the deficiency of this hormone that can deprive a woman of the joy of motherhood. Despite the fact that it is a derivative of testosterone, the hormone has no side effects. It is worth noting that this characteristic is a huge advantage of the medicine. The same cannot be said about many synthetic progestogens, which are necessary components of hormone replacement therapy. Among other things, the drug does not affect the metabolism of carbohydrates and the functioning of the liver, its effect does not affect the processes of ovulation and metabolism.

Pharmacokinetics

A special feature of the drug Duphaston is that it quickly passes from the gastrointestinal tract into the bloodstream. The maximum concentration in the blood after taking the tablets is observed after 2 hours. Further, 97% of dydrogesterone binds to proteins and is hydroxylated in liver cells.

The results of clinical studies confirm that about 64% of the dose of dydrogesterone is excreted naturally, in the urine. Thanks to this, it becomes possible to determine the endogenous level of progesterone. The instructions will help you obtain more specific information about the pharmacokinetics of the drug Duphaston.

Analogues of the drug do not have the properties mentioned above.

Indications for use

Before considering medications that can replace Duphaston, you should understand for what female problems it is prescribed.

Most often, doctors recommend taking the drug Duphaston to women who have been diagnosed with progesterone deficiency. A low level of this particular hormone in a woman’s body is the cause of many troubles, such as the threat of fetal loss, menstrual irregularities, dysmenorrhea, premenstrual syndrome, infertility, secondary amenorrhea, dysfunctional uterine bleeding.

For all of the above ailments and conditions, doctors do not prohibit taking an analogue of Duphaston tablets, but if the budget allows, they recommend using the original drug.

How can I replace Duphaston?

Today, the most famous and most often used drug, which can fully replace the drug Duphaston, is Utrozhestan. But, fortunately, scientists did not stop at developing only this medicine. Therefore, today a woman who wants to conceive and safely carry a baby can purchase the most suitable option from a wide range of drugs. Of course, it is worth noting that this choice must be made entirely by the doctor, taking into account the individual characteristics of the patient. But situations in life are different, therefore, after consulting with a pharmacist, you can independently purchase a worthy analogue of Duphaston.

The drug "Urozhestan"

The drug "Utrozhestan" is produced on the basis of plant raw materials diogenin - a Mexican plant, better known as wild yam. It has an antiandrogenic effect and neutralizes the effects of oxytocin, which causes uterine hypertonicity. Also, this Russian analogue of Duphaston has a sedative effect that is useful for pregnant women, but does not predispose to weight gain and does not affect the removal of fluid from the body.

Advantages and disadvantages of the drug "Utrozhestan"

One of the benefits of the medicine is its cost. After all, this analogue of Duphaston is an order of magnitude cheaper than the original. But it is worth remembering that it is strictly prohibited to independently replace the prescribed medicine. Therefore, before you buy this more affordable medication, you need to consult with your doctor, especially when it comes to maintaining a desired pregnancy.

Dydrogesterone product

Like the drug Duphaston, its analogs replenish the deficiency of progesterone in a woman’s body. In particular, the drug "Dydrogesterone" helps maintain the beneficial effect of estrogens on the blood lipid profile. The active ingredient of the drug does not affect coagulation parameters, as well as carbohydrate metabolism and liver function. In addition, the advantages of the drug include the absence of androgenic, estrogenic, thermogenic, corticoid or anabolic activity.

Today, Dydrogesterone is a good and affordable Russian analogue of Duphaston. This synthetic progestogen is indicated for endogenous progesterone deficiency.

Remedy "Prajisan"

This modern analogue of Duphaston is a hormonal agent with progesterone. It is used in the treatment of long-term infertility, as well as luteal phase deficiency. Effective for various disorders of the menstrual cycle, premenopause, fibrocystic mastopathy and other ailments.

Since the drug has a wider spectrum of action than Duphaston, it is used only before pregnancy. Exceptions are cases when the benefits to the mother's body outweigh the possible risk of negative effects on the fetus.

Which analogue is better?

Only doctors have the right to talk about what medicine can replace Duphaston. Analogs of the drug are selected by a professional, taking into account all the individual characteristics of the patient and the complexity of her disease. Self-prescription of drugs in this group can harm the health of both the mother and the baby, and sometimes cause spontaneous abortion (if the drug is abruptly discontinued).

In this article you can find instructions for use medicinal product Duphaston. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Duphaston in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Duphaston if available structural analogues. Use for the treatment of endometriosis, infertility in women, as well as during pregnancy, planning and breastfeeding.

Duphaston- analogue of natural progesterone. Duphaston in its molecular structure, chemical and pharmacological properties very close to natural progesterone. Due to the fact that dydrogesterone is not a derivative of testosterone, it does not have the side effects characteristic of most synthetic progestogens, the so-called androgenic progestogens.

Dydrogesterone does not have estrogenic, androgenic, anabolic, glucocorticoid and thermogenic activity. Does not provide negative influence on carbohydrate metabolism and liver function.

Dydrogesterone at oral administration selectively affects the endometrium, thereby preventing increased risk development of endometrial hyperplasia and/or carcinogenesis in conditions of excess estrogen. It is indicated in all cases of endogenous progesterone deficiency.

The drug has no contraceptive effect.

When treated with dydrogesterone therapeutic effect achieved without suppressing ovulation or disrupting menstrual function. Dydrogesterone does possible conception and maintaining pregnancy during treatment.

Pharmacokinetics

After oral administration, Duphaston is quickly absorbed from the gastrointestinal tract. Dydrogesterone is metabolized in the liver. Excreted in urine from 56 to 79%.

Indications

endometriosis;
infertility caused by luteal insufficiency;
threatened or habitual miscarriage (with progesterone deficiency);
premenstrual tension syndrome;
dysmenorrhea, irregular menstrual cycle;
secondary amenorrhea (in complex therapy with estrogens);
dysfunctional uterine bleeding;
to neutralize the proliferative effect of estrogens on the endometrium as part of hormone replacement therapy in women with disorders caused by natural or surgical menopause with an intact uterus.

Release forms

Tablets 10 mg.

Instructions for use and dosage regimen

The drug is taken orally.

For endometriosis, 10 mg is prescribed 2-3 times a day from the 5th to the 25th day of the cycle or continuously.

For infertility (caused by luteal insufficiency) - 10 mg per day from the 14th to the 25th day of the cycle. Treatment should be carried out continuously for at least 6 consecutive cycles. It is recommended to continue treatment in the first months of pregnancy as recommended for routine abortion.

In case of threatened miscarriage, 40 mg is prescribed once, then 10 mg every 8 hours until symptoms disappear.

In case of habitual miscarriage, the drug is prescribed 10 mg 2 times before the 20th week of pregnancy, followed by gradual decline doses.

For premenstrual tension syndrome - 10 mg 2 from the 11th to the 25th day of the cycle.

For dysmenorrhea - 10 mg 2 times a day from the 5th to the 25th day of the cycle.

With irregular menstrual cycle- 10 mg 2 times a day from the 11th to the 25th day of the menstrual cycle.

For amenorrhea, estrogens are prescribed once a day from the 1st to the 25th day of the cycle along with Duphaston - 10 mg 2 from the 11th to the 25th day of the cycle.

To stop dysfunctional uterine bleeding, Duphaston is prescribed 10 mg 2 times a day for 5-7 days.

To prevent dysfunctional uterine bleeding, Duphaston is prescribed 10 mg 2 times a day from the 11th to the 25th day of the cycle.

For hormone replacement therapy in combination with continuous estrogen therapy, Duphaston is prescribed 10 mg once a day for 14 days within a 28-day cycle. With a cyclic regimen of estrogen administration, Duphaston is prescribed at a dose of 10 mg 1 time per day during the last 12-14 days of estrogen intake.

If a biopsy or ultrasound examination indicate inadequate reaction for a progestogen drug, daily dose should be increased to 20 mg.

Side effect

headache, migraine;
breakthrough uterine bleeding (which can be prevented by increasing the dose);
possible increased sensitivity of the mammary glands;
minor liver dysfunction, sometimes accompanied by weakness or malaise, jaundice or abdominal pain;
hemolytic anemia;
skin rash, itching;
urticaria, Quincke's edema;
peripheral edema.

Contraindications

hypersensitivity to the components of the drug.

The drug should be prescribed with caution if there is a history of itchy skin in a previous pregnancy.

Use during pregnancy and breastfeeding

It is possible to use Duphaston during pregnancy according to indications.

Dydrogesterone is released from breast milk. Breast-feeding It is not recommended while taking the drug.

Special instructions

If dydrogesterone is prescribed in combination with estrogens (for example, for replacement therapy hormones), contraindications and warnings associated with the use of estrogens should be taken into account.

Before starting hormone replacement therapy (HRT), a complete medical history should be obtained. During treatment, it is recommended to periodically monitor individual tolerance HRT. The patient should be informed about what changes in the mammary glands she should report to the doctor. Studies including mammography should be performed in accordance with routine patient screening.

Sometimes, during the first months of treatment, breakthrough uterine bleeding may occur. If breakthrough bleeding occur after a certain period of taking the drug or continue after a course of treatment, the cause should be studied and an endometrial biopsy should be performed to exclude malignant changes in the endometrium.

Requires careful clinical examination if there is a history of a progesterone-dependent tumor (for example, meningioma), as well as if it progresses during pregnancy or during previous hormonal therapy.

Currently, there is no data on the negative effects of dydrogesterone in chronic renal failure.

Duphaston tablets should not be prescribed to patients with genetically determined galactose intolerance, lactase deficiency or malabsorption syndrome.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive vehicles and control of mechanisms.

Drug interactions

At simultaneous use with Duphaston, inducers of microsomal liver enzymes (such as phenobarbital, rifampicin) can accelerate the metabolism of dydrogesterone and reduce the effectiveness of the drug.

Cases of incompatibility with other drugs are unknown.

Analogues of the drug Duphaston

Structural analogues of the active substance:

Iprozhin;
Crinon;
Prajeesan;
Progesterone;
Progestogel;
Utrozhestan.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

During pregnancy, a woman goes through a difficult period, which requires careful attention to her health and the health of the unborn baby. Starting from the birth of a new life and ending with the birth of a child, the expectant mother has to take various medications. For successful gestation and a favorable pregnancy, duphaston is often prescribed, which has an excellent healing effect and restores hormonal balance. However, this drug is not always available in pharmacies, and its cost may not be affordable for some. Is there an analogue of duphaston among modern medications?

Duphaston is one of the most common drugs used to treat gynecological diseases. The main substance is an artificial hormone, similar to natural progesterone, which is necessary for successful. It normalizes hormone levels and promotes coordinated work female body during pregnancy.

Not in all cases, the duphaston substitute contains identical active ingredients, they may differ slightly, but the therapeutic effect should apply to the same diseases that are treated with duphaston.

Therefore the search worthy replacement this drug should be based not only on the full compliance of the main active ingredient, but also on the similar nature of the therapeutic effect.

The first group of duphaston analogues includes drugs with an absolutely identical active ingredient, dydrogesterone. They are sold in pharmacies under the names Dydrogesterone and Duphaston, with completely identical indications and medicinal effects. They can be used as a complete replacement for duphaston. In addition, each of them is an analogue of duphaston, several times cheaper than the original itself.

Duphaston

When comparing two drugs - duphaston and duphaston, many people wonder what is the difference between these two drugs? According to the latest data, these two drugs are interchangeable, absolutely identical in composition and dosage, but are produced by different manufacturers. In Russia, this drug is officially registered as duphaston, and in Ukraine - duphaston. Therefore, the name of the drug most often depends on the place of its sale. Regarding therapeutic dosage, then these two medications cannot be taken at the same time, as there is a risk of overdose.

Dydrogesterone

Another identical drug is dydrogesterone, which is the main active substance of duphaston. This component is available in pure form How independent drug, therefore its cost can be many times lower than the cost of the duphaston itself. Pure dydrogesterone - complete analogue duphaston during pregnancy, which is prescribed by the doctor as an identical replacement for the main drug. The only drawback of dydrogesterone is that it is not always available in pharmacies.

Another group of drugs, which are a similar replacement, may have different active substances, but they are united by similar medicinal effect and the same indications for use. If it is not possible to purchase duphaston, analogues, cheaper and no less effective, can completely replace this drug.

Utrozhestan

As a result of recent medical developments, a drug has been released that has properties similar to duphaston. Each of these medications contains progesterone, a female hormone. The difference is that this hormone in duphaston is of artificial origin, while the drug utrozhestan uses natural progesterone of natural origin. This contributes to better tolerability of the drug due to the absence of allergies to the components of the drug. However there is certain contraindications because of sedative effect, so it is better not to be taken by those who lead active work. The advantage of utrogestan is also quite low price compared to duphaston.

Progesterone

Indications for the use of progesterone, which contains the main substance gestagen, almost completely coincide with the use of duphaston. This drug differs in its release form - not in tablets, like duphaston, but in the form of an injection solution. Because of this independent use progesterone may cause certain difficulties, so its use is only possible with the help of a qualified medical personnel. In addition, in some cases, a hormonal drug in tablets or capsules may not be absorbed well enough through the intestines, so the doctor may prescribe a course of injections. Taking progesterone in the form of injections helps achieve the desired result in short term, which makes it very effective in critical cases. Compared to the price of the drug duphaston, the analogue is several times cheaper, but it has the same medicinal effect.

Ingesta

A worthy replacement for the drug duphaston - an analogue in the main therapeutic effect, the drug ingesta. This medicine comes in the form liquid solution in ampoules intended for injection. According to the instructions, as active substance progesterone appears, with some additional components. Indications for taking Ingesta include menstrual cycle disorders, infertility, difficulties in bearing a fetus and other disorders. reproductive system, for the treatment of which duphaston is also used.

A comparison of duphaston with each of its analogues shows that when long-term therapy a woman can use one of these medications with a similar effect. This allows for significant cost savings, especially when long-term treatment. It should be remembered that a complete replacement of each drug should be prescribed only by a qualified doctor.

Duphaston is a medicine, a substitute for natural progesterone (main active substance- dydrogesterone).

The drug is prescribed for deficiency of the specified female hormone(regardless of the cause of the problem). Duphaston selectively affects the endometrium, does not affect metabolism, and does not affect liver function.

Indications for use of the drug

endometriosis (abnormal growth epithelial tissue lining inner surface uterus);
infertility caused by a deficiency of progesterone in the body;
unstable menstrual cycle;
uterine bleeding.

The release form of Duphaston is tablets (10 mg). The cost of the product ranges from 491 to 671 rubles. Take the medicine orally in a dosage determined by your doctor.

Taking the drug is associated with a number of side effects - migraines, minor disruptions in the functioning of the gastrointestinal tract, hypersensitivity mammary glands, general malaise, jaundice skin, systemic and local allergic reactions.

Despite this, Duphaston is rightfully recognized as one of the safest and most accessible (albeit not cheap) medicines in its pharmacological group.

Please note: when individual intolerance patients individual components Duphaston, there is a need to select a drug - an analogue with similar clinical properties.

How to replace medicine

Pharmacies sell cheaper medications - analogues of Duphaston made in Russia and abroad.

Domestic analogues

Let's consider effective domestic medicines.

Progesterone

The average cost is 578 rubles. Hormonal drug, whose main task is to create the maximum comfortable conditions for the maturation of a fertilized egg.

Release form - solution in ampoules, intended for intramuscular injection.

Pregnin

Price from 450 rubles. A synthetic substitute for the female hormone progesterone, has a positive effect on the structure of the endometrium and reduces the tone of the uterus during pregnancy. Available in tablets.

Ingesta

Most cheap analogue Duphaston, his price at the pharmacy - from 95 rubles. The main component is progesterone. The drug is prescribed to patients with amenorrhea, when uterine bleeding, infertility.

Foreign substitutes

Duphaston analogues of foreign production.

Utrozhestan

From 300 rubles/pack. The most accurate, cheaper “copy” of the study drug is produced in Belgium. Available in the form of capsules, suppositories, and used orally and intravaginally.

Despite the moderate cost, Utrozhestan is inferior in popularity to Duphaston due to wide range side effects.

Thus, with regular use of the medicine, patients may experience dizziness, increased fatigue, weakness, drowsiness, general malaise.

Reviews about the drug are as follows.

Iprozhin

Price at the pharmacy - from 381 rubles/pack. The drug is a joint production of France and Italy. Refers to drug group gestagens. Good clinical effect demonstrates in the treatment of endometriosis, in the fight against PMS, mastopathy. Iprozhin is prescribed to patients who are about to undergo an IVF procedure (to prepare the uterus for bearing a fetus).

Crinon

From 2565 rubles. Effective gel British and German production. Used intravaginally, it provides additional “release” of the vaginal mucosa of the hormone progesterone.

Prajeesan

From 325 rubles. Indian capsules based on progesterone, soy lecithin and peanut butter. Effective and safe analogue Duphaston.

Megays

An expensive American analogue of Duphaston (from 2,700 rubles) based on megestrol, available in tablets. Belongs to the medicinal group of gestagens, demonstrates good clinical effect in the fight against endometrial cancer and anorexia.

Selection criteria

Absolutely identical in composition and properties to Duphaston pharmaceutical drugs does not exist.