Alcohol solution of iodine: instructions and use. Iodine: instructions for use Alcohol iodine

One bottle (10 ml) contains: active substance: iodine – 0.5 g, Excipients
One bottle (800 ml) contains: active substance: iodine – 40 g, Excipients– potassium iodide, ethyl alcohol, purified water.
One bottle (900 ml) contains: active substance: iodine – 45 g, Excipients– potassium iodide, ethyl alcohol, purified water.

Pharmacotherapeutic group

Antiseptic.
ATX code: D08AG03.

Pharmacological properties

Pharmacodynamics
Antiseptic. The main active ingredient is molecular iodine, which has antimicrobial and antifungal properties. Iodine is able to oxidize and denature the proteins of microorganisms, causing their death. Molecular iodine preparations are characterized by a pronounced local irritating effect on tissue, and in high concentrations, a cauterizing effect. When absorbed and released into the blood, it can have a systemic effect, participating in the synthesis of thyroid hormones.
Pharmacokinetics
Upon contact with skin, 30% is converted into iodides, and the rest remains in the form of elemental iodine. Partially absorbed from the surface of the skin. The absorbed portion can enter tissues and organs, being selectively absorbed by the thyroid gland. Iodine is secreted by the kidneys (mainly), intestines, sweat glands and mammary glands.
The absorption of iodine through damaged skin and mucous membranes can be significant.

Indications for use

It is used externally as an antiseptic for infectious and inflammatory skin diseases, for treating the surgical field, and for preventing infection of minor damage to the integrity of the skin.

Contraindications

Individual intolerance (including a history of hypersensitivity).
Patients with thyroid dysfunction (hyperthyroidism and adenoma) or receiving lithium therapy.
Skin treatment for furunculosis, acne, hemorrhagic diathesis, urticaria, and diabetic trophic ulcers is not allowed.
Dühring's dermatitis herpetiformis.
Newborn period.

Directions for use and doses

For external use, a cotton swab is moistened with an iodine solution and used to treat affected areas of the skin. The medicine should not be used for more than 10 days. When treating the surgical field, the skin is wiped twice with a sterile gauze swab soaked in a solution of the drug. The total processing time is 4-6 minutes.

Side effect

Skin irritation, allergic reactions, including angioedema, urticaria, contact dermatitis, with prolonged use on large wound surfaces - “iodism” (lacrimation, hypersalivation, rhinorrhea, bronchorrhea, swelling of the mucous membranes).
May cause skin hemorrhages or purpuras, fever, arthralgia, lymphadenopathy and eosinophilia.

Overdose

In case of overdose, phenomena of iodism, irritation and burns are possible.
When inhaling concentrated vapors - damage to the upper respiratory tract (burn, laryngo- and bronchospasm); if concentrated solutions get inside - severe burns of the digestive tract; in case of ingestion – development of hemolysis, hemoglobinuria; the lethal dose is about 3 g.
Treatment: gastric lavage with 0.5% sodium thiosulfate solution, intravenous administration of 30% sodium thiosulfate solution - up to 300 ml. In case of a severe skin reaction to iodine, the drug should be immediately removed with 70% ethyl alcohol. It is also recommended to rinse the skin with plenty of water for 15 minutes. In case of accidental ingestion, if the patient is conscious, milk orally every 15 minutes.
Unless the drug is used for the treatment of large open wounds or is used for no more than 10 days, clinically significant systemic absorption is unlikely. Systemic toxicity may result in shock, tachycardia, fever, metabolic acidosis, and renal failure. Death may be caused by circulatory failure, swelling of the epiglottis leading to asphyxia, aspiration pneumonia or pulmonary edema.

Precautionary measures

It is not recommended to use the drug in children under two years of age due to the increased risk of hypothyroidism.
Do not allow the undiluted drug to come into contact with the mucous membranes of the mouth, eyes, vagina and rectum.
It is not recommended for use on deep or puncture wounds or serious burns, as the use of the drug may cause excessive iodine absorption and tissue irritation.
Do not use the medicine for more than ten days!
It is not recommended to treat large areas of skin with the drug.
The use of the drug may affect the results of studies of thyroid function.

Pregnancy and breastfeeding

Children

The use of the drug in newborns is contraindicated and the use of the drug in children under two years of age is not recommended due to the high probability of systemic absorption of iodine when applied externally.
Topical use in children can lead to severe skin reactions to iodine, iodism, and transient hypothyroidism.

◊ Alcohol solution for external use 1% transparent, red-brown in color, with a characteristic odor.

Excipients: ethanol 95%.

15 ml - bottles.

pharmachologic effect

Elemental iodine has pronounced antimicrobial properties. Elemental iodine preparations are characterized by a pronounced local irritating effect on tissue, and in high concentrations - a cauterizing effect. The local effect is due to the ability of elemental iodine to precipitate tissue proteins. Preparations that remove elemental iodine have a much less pronounced irritating effect, and iodides have local irritating properties only in very high concentrations.

The nature of the resorptive effect of elemental iodine and iodides preparations is the same. During the resorptive effect, iodine preparations have the most pronounced effect on the functions of the thyroid gland. In case of iodine deficiency, iodides help restore impaired synthesis of thyroid hormones. With normal iodine content in the environment, iodides inhibit the synthesis of thyroid hormones, the sensitivity of the thyroid gland to pituitary TSH decreases and its secretion by the pituitary gland is blocked. The effect of iodine preparations on metabolism is manifested by increased dissimilation processes. When they cause a slight decrease in the concentration of cholesterol and beta lipoproteins in the blood; in addition, they increase the fibrinolytic and lipoproteinase activity of blood serum and slow down the rate of blood clotting.

Accumulating in syphilitic gums, iodine promotes their softening and resorption. However, the accumulation of iodine in tuberculosis lesions leads to an increase in the inflammatory process in them. The release of iodine by the excretory glands is accompanied by irritation of the glandular tissue and increased secretion. This is due to the expectorant effect and stimulation of lactation (in small doses). However, in large doses, iodine preparations can cause suppression of lactation.

Pharmacokinetics

Upon contact with skin or mucous membranes, 30% is converted into iodides, and the rest into active iodine. Partially absorbed. The absorbed part penetrates tissues and organs and is selectively absorbed by the thyroid gland. It is secreted mainly by the kidneys, intestines, sweat and mammary glands.

Indications

For external use: infectious and inflammatory skin lesions, injuries, wounds, myalgia.

For local use: chronic tonsillitis, atrophic rhinitis, purulent rhinitis, trophic and varicose ulcers, wounds, infected burns, fresh thermal and chemical burns of I-II degree.

For oral administration: prevention and treatment of atherosclerosis, tertiary.

Contraindications

Hypersensitivity to iodine. For oral administration - pulmonary tuberculosis, nephritis, nephrosis, adenomas (including the thyroid gland), furunculosis, acne, chronic pyoderma, hemorrhagic diathesis, urticaria, children under 5 years of age.

Dosage

When applied externally, iodine is used to treat damaged areas of the skin.

For oral administration, the dose is set individually, depending on the indications and age of the patient.

Topically used for washing lacunae and supratonsillar spaces - 4-5 procedures at intervals of 2-3 days, for irrigation of the nasopharynx - 2-3 times a week for 2-3 months, for instillation into the ear and rinsing - for 2-4 weeks; in surgical practice and for burns, gauze napkins applied to the affected surface are moistened as needed.

Side effects

For external use: rarely - skin irritation; with prolonged use on large wound surfaces - iodism (rhinitis, urticaria, salivation, lacrimation, acne).

When taken orally: allergic skin reactions, tachycardia, nervousness, sleep disturbances, increased sweating, diarrhea (in patients over 40 years of age).

Composition and release form of the drug

◊ Alcohol solution for external use 5% transparent, red-brown in color, with a characteristic odor.

Excipients: ethanol 95%.

10 ml - bottles.
15 ml - bottles.
25 ml - bottles.

pharmachologic effect

Pharmacokinetics

Indications

For external use: infectious and inflammatory skin lesions, injuries, wounds, myalgia.

For local use: chronic tonsillitis, atrophic rhinitis, purulent rhinitis, trophic and varicose ulcers, wounds, infected burns, fresh thermal and chemical burns of I-II degree.

Contraindications

Hypersensitivity to iodine.

Dosage

When applied externally, iodine is used to treat damaged areas of the skin.

Topically used for washing lacunae and supratonsillar spaces - 4-5 procedures at intervals of 2-3 days, for irrigation of the nasopharynx - 2-3 times a week for 2-3 months, for instillation into the ear and rinsing - for 2-4 weeks; in surgical practice and during treatment, gauze napkins applied to the affected surface are moistened as needed.

Side effects

For external use: rarely - skin irritation; with prolonged use on large wound surfaces - iodism (rhinitis, urticaria, Quincke's edema, salivation, lacrimation, acne).

Drug interactions

Pharmaceutically incompatible with essential oils, white sedimentary mercury (an explosive mixture is formed). An alkaline or acidic environment, the presence of fat, pus, and blood weaken the antiseptic activity.

Iodine is a drug that has a local irritant, anti-inflammatory, antiseptic, pronounced antimicrobial and, in high concentrations, a cauterizing effect. It has bactericidal activity against gram-positive and gram-negative microflora (especially Proteus spp., Escherichia coli and Streptococcus spp.), pathogenic fungi and yeast. Causes the death of spores of the pathogen Bacillus anthracis.

Release form and composition

The dosage form of Iodine is a 5% alcohol solution.

Composition of the drug: iodine, potassium iodide, 95% ethanol, purified water.

Indications for use

According to the instructions for Iodine, the indications for use of the drug are:

For external use: abrasions, injuries, wounds, myalgia, infectious and inflammatory skin lesions, inflammatory infiltrates, myositis, neuralgia;
For local use: purulent otitis, atrophic rhinitis, chronic tonsillitis, varicose and trophic ulcers, wounds, chemical and thermal burns of I-II degrees, infected burns;
For oral administration: tertiary syphilis, atherosclerosis (treatment and prevention).

In addition, Iodine is used to disinfect the surgeon’s fingers, wound edges and the surgical field (before and after surgery), and for antiseptic treatment of body parts during catheterization, puncture and injections.

Contraindications

Regardless of the method of application, iodine, according to the instructions, is contraindicated in case of hypersensitivity to the drug.

It is forbidden to take the medicine internally:

Children under 5 years old;
Pregnant women;
For pulmonary tuberculosis;
Patients with chronic pyoderma;
For nephritis and nephrosis;
For furunculosis and acne;
Patients with hemorrhagic diathesis;
For urticaria.

Directions for use and dosage

When used externally, iodine is applied to damaged or treated areas of the skin.

Place used:

To wash lacunae (depressions on the surface) of the tonsils and supratonsillar spaces (adjacent to the tonsils) - 1 procedure once every 2-3 days, a total of 4-5 procedures;
For irrigation of the nasopharynx - 2-3 times a week, treatment - up to 3 months;
For instillation into the ear and rinsing - as prescribed by a doctor;
To gargle – several times a day with an aqueous solution (5 ml of iodine per 50 ml of water);
In surgical practice and for burns, gauze wipes soaked in Iodine are applied to the affected areas as needed.

If it is necessary to take iodine orally, the dose in each case is determined individually by the doctor. The required amount of the drug should be dissolved in milk and taken after meals.

To prevent atherosclerosis, adults are prescribed 1-10 drops once or twice a day for 30 days. It is recommended to conduct 2-3 such courses per year. When treating atherosclerosis, they usually take 10-12 drops three times a day. For tertiary syphilis, a single dose varies from 5 to 50 drops; iodine solution should be taken 2-3 times a day.

The maximum single dose for adults is 20 drops, daily dose is 60 drops.

For children, oral iodine is prescribed 3-5 drops per 1/2 glass of milk 2-3 times a day.

Side effects

In most cases, the drug is well tolerated.

When taking Iodine orally, skin allergic reactions, increased sweating, sleep disturbances, diarrhea, nervousness, tachycardia may occur, and if a large concentration is taken, a chemical burn may occur.

When Iodine is used externally, skin irritation is sometimes observed. In case of hypersensitivity to the drug and with prolonged use on large areas of the body, there is a possibility of developing iodism, manifested by acne, lacrimation, drooling, urticaria, cough, rhinitis, metallic taste in the mouth, thirst, Quincke's edema, diarrhea, and general weakness.

special instructions

Iodine is pharmacologically incompatible with white sedimentary mercury, ammonia solutions and essential oils. Such combinations are strictly contraindicated!

Iodine reduces the hypothyroid and goitrogenic effects of lithium preparations, and its antiseptic activity is weakened by an acidic and alkaline environment, the presence of blood, pus and fat.

The drug should be used very carefully to prevent the solution from getting into the eyes.

High temperature (more than 40 ºС) and light accelerate the breakdown of active iodine.

The diluted solution cannot be stored for long periods of time.

Analogs

The following drugs belong to the same pharmacological group (“Iodine Preparations”) and have a similar mechanism of action: Aquazan, Braunodin B. Brown, Braunodin B. Brown Povidone-Iodine, Betadine, Iodine-Ka, Iodinol, Iodine tablets, Iodovidone, Iodonate , Yodopirone, Iodoflex, Yoduxun, Lugol, Lugol's solution with glycerin, Povidone-iodine, Octasept, Stellanin, Stellanin-PEG, Sulyodovisol, Sulyodopirone.

Terms and conditions of storage

According to the instructions, the drug should be stored in a dark place at a temperature not lower than 0 ºC. The shelf life of the solution is 3 years.

Description

Transparent liquid of red-brown color with a characteristic odor.

Pharmacotherapeutic group

Antiseptics and disinfectants. Iodine preparations.

ATX code D08AG03

Pharmacological properties

Antiseptic. The main active ingredient is molecular iodine, which has antiseptic properties. When applied to large areas of the skin, iodine has a resorptive effect: it affects the functions of the thyroid gland. The local effect is due to the ability of elemental iodine to precipitate tissue proteins. A drug that removes elemental iodine has a much less pronounced irritant effect. The effect of the drug on metabolism is manifested by increased dissimilation processes.

Indications for use

For local use in surgical practice

Treatment of abrasions, cuts, small wounds

Directions for use and doses

Externally, treat damaged skin areas. Locally: when treating the surgical field, the skin is wiped twice with a sterile gauze swab soaked in the solution. The total processing time is 4-6 minutes. For local use, gauze pads are pre-moistened with iodine solution and applied to the affected skin surface for at least 2 minutes.

Side effects

Allergic reaction to iodine (skin itching, flushing, urticaria, skin irritation)

Quincke's edema, intradermal hemorrhages, purpura

Fever, arthralgia, lymphadenopathy, eosinophilia

Contraindications

Hypersensitivity to iodine

Thyroid diseases

Use simultaneously with lithium preparation

Dermatitis herpetiformis

Drug interactions

Iodine use affects the results of thyroid function tests. Pharmaceutically incompatible with essential oils and enzymes. An alkaline or acidic environment, the presence of fat, pus, and blood weaken the antiseptic activity of the drug.

special instructions

Avoid prolonged use.

For external use only.

Do not cover iodine solutions applied to the skin with occlusive dressings.

Do not use on large, open wounds.

When used together with yellow mercury ointment, the formation of mercury iodide, which has a cauterizing effect, is possible.

Use in pediatrics

Pregnancy and lactation

It is possible to use the drug as prescribed by a doctor.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Does not affect

Overdose

Do not use internally! In case of accidental use internally.

Symptoms: unpleasant metallic taste in the mouth, vomiting, abdominal pain, diarrhea, thirst, headache. The lethal dose of iodine is 2-3g. Treatment: symptomatic treatment of allergic reactions; in case of acute poisoning, abundant consumption of milk and vegetable starch, activated carbon, and the use of sodium thiosulfate solution are recommended

1% or 5%. The lack of electrolytes and water must be compensated.

Pethidine or morphine sulfate can be used to relieve pain, only under medical supervision. If necessary, tracheotomy.