Treatment of drug-induced hepatitis. Drug-induced hepatitis

Chronic hepatitis name a group of liver pathologies that arise against the background various factors and are characterized by the appearance of an inflammatory process and necrosis of gland cells varying degrees gravity. According to modern international classification, drug-induced hepatitis is one of the representatives of diseases of this group. Next, we consider the manifestations of the disease, the reasons why it develops, and the answers to the question of whether it is possible to cure a pathology with such a formidable name.

Drug-induced hepatitis is a lesion of hepatocytes (liver cells) that develops under the influence of breakdown products of various medications. Pathology occurs against the background of intensive treatment in every sixth or seventh patient. In a quarter of such patients, the disease progresses to more complex conditions (for example, replacement of liver cells connective tissue with further loss of performance). It is known that females are several times more likely to develop drug-induced hepatitis than males.

There are following forms diseases:

spicy drug-induced hepatitis(cholestatic, cytolytic and combined type);
chronic drug-induced hepatitis (CHD).

The liver is considered one of the largest organs. Its functions are to inactivate toxins and toxic substances, cleanse the body, produce bile, form and destroy blood cells. Purification is carried out thanks to specific enzymatic processes that occur inside hepatocytes. The result is that substances neutralized by the liver are removed from the body.

The destruction of substances toxic to humans occurs in the form of several sequential processes, during which specific products are formed. Such breakdown products of a number of medications are even more toxic to the gland than themselves medicines.

Long-term use of medications or their high dosage lead to depletion of enzymatic systems and damage to liver cells. As a result, toxic drug-induced hepatitis develops.

The modern pharmacological market has more than 1000 medications that can provoke the development of the disease. Negative impact on the liver increases several times with the combined use of several drugs, and with the simultaneous use of 6 or more types of drugs, the risk of developing the disease increases to 85%. The process of formation of liver pathology can occur from 3-4 days to several years.

Factors provocateurs

The main factors that can provoke the occurrence of drug-induced hepatitis:

individual sensitivity to active substances medicines;
chronic hepatitis of a different nature;
development of ascites (accumulation of fluid in abdominal cavity);
alcohol abuse;
toxic effects of toxic substances entering the body during the performance of professional duties;
period of bearing a child;
insufficient intake of protein substances from food;
stressful situations;
severe pathologies of the heart and kidneys.

The only condition for the development of pathology is a combined action unfavorable factors and drug therapy.

List of medications that can provoke the development of drug-induced hepatitis:

Drugs used to combat tubercle bacilli (isoniazid, PAS).
Hormonal drugs (combined oral contraceptives, steroids).
Diuretics (Veroshpiron, Hypothiazide).
Antiarrhythmic drugs (Amiodarone).
Antibacterial drugs (representatives of penicillins, macrolides, tetracyclines).
Sulfonamide drugs (Biseptol, Sulfalen).
Antimycotics (Ketoconazole, Amphotericin B).
Antineoplastic agents (Methotrexate).
Non-steroidal anti-inflammatory drugs (Diclofenac).

This is not the entire list of medications that can cause drug-induced hepatitis during therapy.

Manifestations of the disease

Symptoms of drug-induced hepatitis depend on the course of the disease and the severity of the pathological process. The clinical picture is similar to other forms of hepatitis. The patient complains of bright manifestations from the side gastrointestinal tract: attacks of nausea and vomiting, flatulence, sharp decline loss of appetite, bitter belching, problems with stool.

Cephalgia, discomfort and heaviness appear in the projection of the affected organ. During palpation, the attending physician determines the presence of pain and an increase in the size of the liver. The progression of the pathology is accompanied by the development of jaundice. The patient's skin and sclera become yellow, feces become discolored, and urine, on the contrary, acquires a dark tint. There is itching of the skin, the presence spider veins, rashes of various types.

Known clinical cases, when the disease was at its peak, it was diagnosed by laboratory tests, and the patient did not even suspect its presence due to the absence of symptoms.

Diagnostics

The diagnostic process begins with collecting an anamnesis of life and illness, visual inspection patient, palpation of the affected area. Next, they prescribe general tests (blood, urine), determining the state of the blood coagulation system,
biochemistry (indicators of ALT, AST, bilirubin, alkaline phosphatase, protein fractions).

An ultrasound examination of the liver will determine an increase in the size of the liver (sometimes together with the spleen), heterogeneous structure her fabrics. The specialist must exclude other types of hepatitis (alcoholic, viral, autoimmune). This may require a liver biopsy, which can determine the absence of specific changes in hepatocytes. As a rule, the presence of a large number of eosinophils, granulomas, and a clear line between unaffected tissue and areas of cell necrosis is confirmed.

To carry out differential diagnosis with viral hepatitis, serological tests and PCR are prescribed.

Features of treatment

The treatment regimen is developed by a hepatologist. Treatment of drug-induced hepatitis should be timely. This will help prevent the disease from progressing to cirrhosis or liver failure. Basic principles:

The medicine that caused the disease should be discontinued. A similar issue is discussed with those specialists who prescribed therapy. concomitant diseases. If necessary, replace it with another medication.
Detoxification treatment of drug-induced hepatitis is the purification of the patient’s blood from those metabolites that have a toxic effect on the body. To do this, infusion is carried out with Hemodez; if necessary, hemodialysis or plasmapheresis is used, and the introduction of specific antidotes.
Restorative therapy with hepatoprotectors - drugs that protect the gland from negative influence external and internal factors, restoring functional state hepatocytes. Representatives: Gepabene, Karsil, Heptral.
Therapy aimed at eliminating symptomatic manifestations(for example, antiemetics, sorbents).

Nutrition correction

Diet for drug-induced hepatitis - link complex treatment pathology. Experts recommend that the patient not just follow therapeutic nutrition, but also change habits and lifestyle in general.

Patients must follow the rules of table No. 5. This diet is prescribed for all types of hepatitis, cirrhosis, and liver failure. Peculiarities:

Liver pathology requires compliance drinking regime. Sufficient quantity liquid maintains water-electrolyte balance, reduces the viscosity of bile, and helps relieve the inflammation process.

You can drink mineral waters that have sulfate groups. They activate the intestinal tract, reducing the load on the liver, normalize the outflow of bile, and eliminate spasms. structural elements biliary system. The same waters can be used to carry out medicinal baths(duration – 10 minutes, temperature – 36 o C, number – 10-12 procedures).

Sample menu for drug-induced hepatitis

Breakfast – low-fat cottage cheese with banana, tea.

Snack – apple.

Lunch – vegetable soup, boiled chicken fillet, salad fresh vegetables.

Snack – yogurt.

Dinner – rice, fish, baked vegetables.

Snack – a glass of tea, biscuits.

Prevention

Preventive measures aimed at preventing the development of drug-induced hepatitis include timely diagnosis state of the body (including the liver), refusal to drink alcohol and smoke. The selection of treatment for any pathology should be carried out qualified specialist after complete comprehensive examination patient. When prescribing hepatotoxic medicinal drugs hepatoprotectors should be taken.

Drug-induced hepatitis – serious illness, which can develop at lightning speed, even leading to hepatic coma and death. To avoid this, you should avoid self-medication, promptly seek help from doctors and follow all prescribed recommendations. In this case, a favorable prognosis can be achieved.

Drug-induced hepatitis is a liver disease characterized by the occurrence of inflammatory processes in hepatocytes under the influence of pharmacological drugs. About 25% of people undergoing therapy various pathologies face manifestations of drug-induced hepatitis. In women, this disease is diagnosed several times more often than in men and occurs with numerous complications. Doctors attribute this to the fair sex’s commitment to self-medication.

Pathogenesis

Liver disease

Cells are subject to intoxication even under the influence of conventional diuretics and analgesics. Doctors never tire of repeating that self-medication is extremely dangerous, but every year thousands of people who have destroyed their livers by uncontrolled use of medications end up in hospital beds. Doctors know that many pharmacological drugs have toxic properties and prescribe them to patients with the greatest caution, only if the benefit outweighs the risk.

The liver is a universal biological filter for neutralizing blood from toxic substances and metabolic products. Medicines are not capable of causing significant harm in gentle dosages. Specific proteins enter into contact with them chemical reactions with the formation of large molecules - metabolites. Metabolites that are unnecessary for the body are removed from the body, the rest are delivered to target organs for further treatment.

If a person begins to abuse the use of pharmacological drugs, then hepatocytes cease to cope with excessive load. Metabolites begin to accumulate in the liver tissues and provoke intoxication. The end result The negative process becomes irreversible deformation of hepatocyte cells.

Etiology

Drug-induced hepatitis can develop in the human body for several reasons. Doctors identify three main factors leading to liver cell death:

Proteins are the building blocks of liver cells. Therefore, people who adhere to monotonous diets are at risk. In the absence of proteins and their metabolic products, complete breakdown of molecules does not occur. chemical compounds.

What drugs cause drug-induced hepatitis?

The toxic effects of drugs are enhanced when they are taken simultaneously with alcohol and other medications multiple times. Toxic hepatitis is provoked by the presence of diseases in a person:

chronic renal failure;
cardiovascular failure;
circulatory disorders.

All these pathologies require long-term treatment with drugs that provide negative impact on liver cells. Toxic effect may have only one of the drugs or a combination of them. Such medications include:

Antitumor drugs and cytostatics.
Non-steroidal anti-inflammatory drugs.
Antibiotics and antimicrobials.
Anti-tuberculosis drugs.
Sulfonamide drugs.
Anticonvulsant medications.
Fungicidal preparations.
Antiepileptic drugs.
Drugs for treatment diabetes mellitus and thyroid diseases.
Antiarrhythmic drugs.

The above medications have pronounced hepatotoxic properties. This does not mean that you can use other pills uncontrollably. Even “harmless” Analgin and Aspirin can cause drug-induced hepatitis and fatal intoxication.

Species

There are several classifications of drug-induced hepatitis, but when diagnosing doctors, they use two main ones, based on the methods of treatment:

Targeted toxic effects. In this case, doctors predict the occurrence of drug-induced hepatitis and try to take measures to reduce dangerous side effects. But without the use of these medications, a person’s life is at mortal risk.
Indirect toxic effects. The precautions taken are not always able to prevent the development of drug-induced hepatitis. Hereditary predisposition The body's response to this complex of chemical compounds can provoke the development of drug-induced hepatitis.

There are acute and chronic stage liver diseases. Acute drug-induced hepatitis occurs approximately ten days after taking a pharmacological drug. A person may already forget about using the drug, and at this time the liver cells in his body are rapidly destroyed. This situation occurs extremely rarely and only in two cases. At individual intolerance drug, accompanied by the manifestation of extensive symptoms allergic reaction, as well as when taking a drug that has a pre-predicted toxic effect.

Chronic drug-induced hepatitis often occurs without any clinical symptoms. The patient can learn about the presence of a disease when diagnosing the pathology of the neighboring internal organ. Liver cell destruction occurs over several months or years. How this or that drug will affect hepatocytes cannot be determined even approximately. The insidiousness of the disease lies in the frequent absence of pronounced symptoms. CLH is diagnosed in patients who are forced to regularly take pharmacological drugs to treat systemic pathologies.

Symptoms

You should immediately contact medical institution, if any following symptoms drug-induced hepatitis:

TO side symptoms drug hepatitis includes arterial hypertension, which, with increasing intoxication, is replaced by sharp drop pressure.

Diagnostics

Diagnosis begins with a survey of the patient by the attending physician and a study of diseases in his medical history. If a person’s skin turns yellow, and upon palpation the liver is clearly enlarged, the doctor will immediately suspect toxic hepatitis. To confirm the diagnosis, the patient will be required to undergo biochemical tests:

Blood. Platelet concentration allows us to estimate general condition human health.
Urine. An increased content of leukocytes and protein breakdown products indicates the presence of an inflammatory focus.
Determination of bilirubin, AST.

Before treating the pathology, a coagulogram is prescribed to determine the level of blood clotting. If necessary, carried out ultrasound examination, computed tomography, magnetic resonance imaging.

Symptoms and treatment of drug-induced hepatitis are closely related to the level of transaminases - liver enzymes. The increase in their concentration is directly dependent on the number of damaged hepatocytes. This is why it is extremely important to check transaminase levels when taking any medications.

Therapy

Treatment of drug-induced hepatitis begins with discontinuation of the drug that provoked the disease. Cancellation should occur in agreement with the attending physician and after testing. The doctor may completely change the drug or reduce its dosage.

In order to prevent possible development encephalopathy, detoxification therapy is carried out using drugs and (or) devices to remove accumulated toxins from the body. After blood disinfection, treatment of drug-induced hepatitis with hepatoprotectors begins. Medicines that can restore damaged liver cells include: Essentiale forte, Heptral, Essliver forte, Gepabene, Phosphogliv and Phosphogliv forte.

To strengthen the body’s condition, doctors recommend that patients take it according to the following regimen: vitamin complexes And minerals. Antispasmodics will help relieve painful spasms: No-shpa, Spazmalgon, Spazgan.

Therapy will not bring results if the patient does not adhere to a diet for drug-induced hepatitis. For patients with any liver diseases, “Table No. 5” is suitable, compliance with which includes the following rules:

exclusion from the diet of salty, fried, spicy and fatty foods;
eating small portions up to 6 times a day;
quitting smoking and drinking alcohol;
preference for products with a large number carbohydrates.

When following a diet, you should take vitamins and additional amino acids. To prevent dangerous relapses and to never find out what drug-induced hepatitis is, you must stop taking pharmacological drugs not prescribed by your doctor.

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Drug-induced hepatitis is an inflammatory process in the liver provoked by certain medications. If treatment of the disease is not started in a timely manner, then the onset of necrotic processes in the affected organ and cirrhosis is quite possible. In advanced stages is no exception death. According to statistics, drug-induced hepatitis is diagnosed three times more often in women than in men. This circumstance scientific explanation doesn't have one yet.

Etiology

The main cause of drug-induced hepatitis is long-term use and high dosage of hepatotoxic drugs. Their exposure leads to the depletion of enzymes that neutralize active ingredients medications, and damage to organ cells.

To risk factors for the formation of this disease should include:

presence in the anamnesis;
abuse of alcoholic beverages and surrogates;
contact with toxic substances;
pregnancy;
poor nutrition;
prolonged nervous tension;
genetic predisposition.

TO medications that can trigger the development of toxic drug-induced hepatitis include:

antibiotics, especially the tetracycline group;
anti-tuberculosis;
cytostatics;
diuretics;
non-steroidal anti-inflammatory drugs;
antimicrobial;
proton pump inhibitors;
hormonal;
antidiabetic;
drugs for the relief of epileptic attacks and convulsions.

It should also be understood that moderate use of drugs from this list, subject to the doctor’s recommendations and with strong immune system should not be considered as a 100% predisposition to the development of drug-induced hepatitis.

It should be noted that this type the illness has no clear definition incubation period. This disease can develop both over several years of taking medications, and several weeks after the start of treatment with certain medications.

Some patients develop chronic drug-induced hepatitis, which is difficult to treat. As a rule, this form of the disease occurs in people who are forced to take certain medications constantly.

Classification

Based on the nature of the disease, two forms are distinguished:

acute – characterized by an intense clinical picture, responds relatively well to treatment;
chronic form - often develops over several years, is difficult to treat, and often leads to...

Regardless of what caused the development of this pathological process, treatment should begin immediately.

Symptoms

Symptoms of drug-induced hepatitis are almost identical clinical picture viral hepatitis. The clinical picture appears as follows:

pain, feeling of heaviness in the right hypochondrium;
nausea, often with vomiting. Sometimes vomit may contain bile;
general weakness, malaise;
dysfunction of the gastrointestinal tract;
attacks of diarrhea after eating fatty, heavy foods;
feeling of heaviness in the stomach, even with minimum quantity food consumed;
yellowness of the skin;
itching on the body;
saturated dark color urine;
stool discoloration;
enlarged liver and spleen.

It should be noted that chronic drug-induced hepatitis (CHD) long time may be asymptomatic. In some cases, the patient may feel uneasy, especially while taking medications, periodic pain in the abdomen, heaviness in the right hypochondrium and short-term disruption of the functioning of the gastrointestinal tract. Symptoms may disappear completely after stopping the use of drugs. That is why the chronic form of the disease is often diagnosed in an advanced stage.

The manifestation of such symptoms does not always indicate drug-induced hepatitis, so you cannot take treatment on your own. Such medical events can aggravate the development of the pathological process, which can also lead to the formation of concomitant diseases. Death is no exception.

Diagnostics

If you have the above symptoms, you should consult a doctor. After clarifying the complaints, medical history and life history, the doctor prescribes an examination.

The diagnostic program may include the following methods:

general and biochemical analysis blood;
general urinalysis;
coagulogram;
coprogram;
Ultrasound of the abdominal organs;
liver biopsy.

Since the clinical picture is quite ambiguous and may be a manifestation of other liver diseases, it is carried out differential diagnosis to exclude or confirm such diseases:

oncological process;
liver tumor;

The therapy program will be prescribed by the attending physician after precise setting diagnosis and identification of the etiology of the disease.

Treatment

Treatment of drug-induced hepatitis is only comprehensive, with adherence to diet therapy.

First of all, the use of hepatotoxic drugs is discontinued. Then, detoxification therapy is prescribed.

For removal from the body toxic substances assigned:

infusion therapy;
in more severe cases - plasmapheresis and hemodialysis.

Drug therapy involves replacing a hepatotoxic drug with safe analogue. If this is not possible, then to prevent the development of chronic drug-induced hepatitis, hepatoprotectors are prescribed.

The duration of medication, dosage and regimen are strictly prescribed by the attending physician. Making unauthorized adjustments to the course of treatment is unacceptable.

The treatment program for both acute and chronic drug-induced hepatitis necessarily includes diet therapy. A diet for toxic drug-induced hepatitis involves excluding the following:

alcoholic drinks;
fatty meats, fish, offal;
products with increased content cholesterol;
cocoa, strong tea, coffee;
chocolate;
products containing oxalic acid.

The patient's diet should consist of light, but at the same time nutritious foods. The diet implies the following daily protein-energy composition:

carbohydrates - 350–400 grams;
fats - no more than 90 grams, of which 30 grams are of vegetable origin;
proteins – no more than 100 grams, of which 60 grams are of animal origin;
table salt no more than 4 grams per day.

Food should only be warm, steamed or boiled. The preferred consistency of dishes is liquid, grated, puree. The patient should eat frequently (4–5 times a day), in small portions and at intervals of 2.5–3 hours.

Compliance with the drinking regime is also important. The volume of liquid you drink per day should be at least two liters. Recommended consumption mineral water without gas.

Forecast

If treatment for drug-induced hepatitis is started in a timely manner, it is possible full recovery liver functioning. Otherwise, the development of serious pathological processes – liver cirrhosis, etc. – is possible. A fatal outcome cannot be ruled out.

Prevention

Preventive measures for this disease are as follows:

taking only medications prescribed by a doctor and following their dosage;
timely and correct treatment all diseases;
preventive examination by specialized medical specialists.

If you have any of the above symptoms, you should seek help from qualified professionals. medical specialists rather than self-medicate.

Is everything correct in the article? medical point vision?

Answer only if you have proven medical knowledge

Diseases with similar symptoms:

Jaundice – pathological process, the formation of which is influenced by a high concentration of bilirubin in the blood. The disease can be diagnosed in both adults and children. Call this pathological condition Any disease can, and they are all completely different.

– reactive inflammatory lesion liver caused by taking hepatotoxic medications. Signs of drug-induced hepatitis may include nausea, vomiting, decreased appetite, constipation or diarrhea, jaundice, dark urine and light-colored stool. Diagnosis of drug-induced hepatitis is made on the basis of anamnesis, determination of the level of liver tests, and ultrasound of the liver. Treatment of drug-induced hepatitis requires discontinuation of the pharmaceutical drug that caused liver damage, detoxification therapy, and the prescription of gapatoprotectors.

The main groups of drugs that cause drug-induced hepatitis include:

Drugs for the treatment of tuberculosis (rifampicin, isoniazid)
Antibiotics: tetracyclines (tetracycline, chlortetracycline, dixycycline), penicillins (benzylpenicillin, amoxicillin, etc.), macrolides (erythromycin)
Sulfonamides (sulfamethoxazole + trimethoprim, sulfadimethoxine, etc.)
Hormones ( steroid hormones, oral contraceptives, etc.)
NSAIDs (diclofenac, ibuprofen)
Anticonvulsants and antiepileptic drugs (phenytoin, carbamazepine, clonazepam, etc.)
Antifungal drugs (amphotericin B, ketoconazole, fluorocytosine)
Diuretics (hydrochlorothiazide, furosemide, etc.)
Cytostatics (methotrexate)
Drugs for the treatment of arrhythmia, diabetes mellitus, peptic ulcer and many more etc.

The list of drugs that have hepatotoxic effects is far from exhausted by the medications mentioned above. Drug-induced hepatitis can be caused by almost any medicine and especially - a combination of several drugs.

Symptoms of drug-induced hepatitis

Drug-induced hepatitis can occur in acute or chronic form. Acute drug-induced hepatitis, in turn, is divided into cholestatic, cytolytic (occurring with necrosis and fatty hepatosis) and mixed.

The symptoms of drug-induced hepatitis are similar to those of other types of hepatitis. The dominant ones in the clinical picture are dyspeptic disorders: loss of appetite, nausea, bitter belching, vomiting, diarrhea or constipation, weight loss. Main clinical manifestations may be preceded by a prodromal period occurring with asthenic or allergic syndrome. With drug-induced hepatitis, moderate pain, heaviness, and discomfort in the right hypochondrium are disturbing; Palpation reveals hepatomegaly and liver tenderness. Sometimes jaundice develops against the background of drug-induced hepatitis, itchy skin, fever, lightening of stool and darkening of urine.

In some cases, drug-induced hepatitis can be detected only on the basis of changes in biochemical parameters blood. Acute drug-induced hepatitis, which occurs with the formation of submassive necrosis, quite quickly leads to cirrhosis of the liver. With massive liver necrosis, liver failure develops.

Diagnostics

In the process of diagnosing drug-induced hepatitis, it is important to exclude viral hepatitis, cholelithiasis, liver tumors, pancreatic cancer. When collecting anamnesis, it is important to find out the cause-and-effect relationship of liver damage with taking hepatotoxic drugs.

If drug-induced hepatitis is suspected, biochemical liver tests are examined, in which the activity of transaminases (AST, ALT) and alkaline phosphatase, bilirubin level, and globulin fractions increase. A coagulogram is examined, general analysis urine and blood, coprograms.

Ultrasound of the abdominal organs can reveal diffuse increase liver, however, does not allow us to judge the cause of hepatitis.

Treatment of drug-induced hepatitis

The first step in the treatment of drug-induced hepatitis is to discontinue the drug that is suspected of causing liver damage and replace it with a safer analogue. The patient is strictly prohibited from changing medications on his own. In order to remove toxic metabolites from the body, detoxification infusion therapy, plasmapheresis, and in severe cases, hemodialysis are performed.

To restore damaged liver cells, hepatoprotective drugs (essential phospholipids, ademetionine, methionine) are prescribed. When prescribing medications with known hepatotoxic potential, preventive use of hepatoprotectors is recommended, which helps prevent the development of drug-induced hepatitis.

Prognosis and prevention

In severe cases, with lightning-fast development drug hepatitis or massive necrosis of the hepatic parenchyma, cirrhosis, liver failure, and sometimes hepatic coma and death develop. With timely discontinuation of the hepatotoxic drug in most cases, complete recovery occurs.

Prevention of drug-induced hepatitis involves rational use medications, monitoring side effects, taking medications only as prescribed by a doctor, excluding additional toxic influences. Against the background of a long drug therapy It is recommended to prescribe hepatoprotectors. Patients who are forced to take medications for a long time need to periodically examine the level of transaminases in order to identify drug-induced hepatitis at an early stage.

Drug-induced hepatitis is a disease in which a reactive inflammatory process occurs in the liver. It begins when a person takes hepatotoxic drugs medical supplies. Hepatocytes are affected.

These are liver parenchyma cells that are involved in many processes:

protein synthesis and storage;
cholesterol synthesis;
detoxification;
synthesis of lipids and phospholipids;
removal of endogenous elements from the body;
initiation of bile formation.

Drug metabolites contribute not only to the development of the inflammatory process, but also lead to cell necrosis, liver cirrhosis and liver failure. In men, drug-induced hepatitis is less common, mainly inflammatory process women are susceptible.

There is another type of disease, namely. It develops against the background of poisoning with pesticides, fungal toxins, and industrial alcohol.

Toxic hepatitis occurs not only when a person has eaten or drunk something, infection can occur through respiratory tract or pores skin. The ingress of industrial poisons can provoke such a disease.

Very often, doctors encounter mushroom poisoning. This is toxic hepatitis. But in most cases it is fatal.

Reasons why hepatitis may occur

The liver can be called the ideal filter in all of nature. It is responsible for neutralizing and removing toxic substances that enter it with the blood. When the blood contains for a long time large number drug metabolites, liver cells begin to break down. Conclusion harmful substances from the body occurs in several stages. During this process, the formation of metabolites (intermediate products of biological transformation) occurs. Medicines contain elements that are too hepatotoxic, which have a detrimental effect on cells and the liver as a whole.

If a person takes very for a long time Such drugs cause depletion of the neutralizing enzymatic system and damage to hepatocytes. As a result, drug-induced or drug-induced hepatitis begins to develop. Today, about 1000 medications are known that can cause hepatitis. The risk of liver cell inflammation increases tenfold if several medications are taken at once. Simultaneous use 8-9 medications increase the damage to hepatocytes by 93%. The development of the disease can take from 2 days to 1 year. Also reasons may be:

Drug-induced hepatitis occurs mainly if the dosage of medications is violated or the wrong combination of medications is taken.

Drug-induced hepatitis: symptoms and signs

With drug-induced hepatitis, the same symptoms occur as with all known types of the disease. These include:

fatigue;
weakness;
sleep disorders;
periodic headache;
yellowing of the skin and whites of the eyes;
pain and heaviness in the liver area (right hypochondrium);
bitter taste in the mouth;
loss of appetite;
diarrhea;
nausea, vomiting;
intensive weight loss.

Since hepatitis has the same symptoms as hepatitis A, hepatitis B, hepatitis C, treatment can only be prescribed by a doctor after full examination. Under no circumstances should you self-medicate or try to correct the situation with medications, even those miraculous medications that commercials talk about. This can only aggravate the situation and personally contribute to an even more intensive development of the disease.

Treatment of drug-induced (drug-induced) hepatitis

Treatment of drug-induced hepatitis begins with diagnostic examination and taking tests. It is very important to understand that a person really has drug-induced hepatitis, because the course of treatment depends on this. Diagnosis is carried out using the following methods:

general blood and urine analysis;
biochemical blood test (determining the level of bilirubin in the blood, bilirubin and protein fractions);
study of the blood coagulation system (coagulogram);
palpation;
Ultrasound of the liver.

If the disease is confirmed, doctors discontinue the drug, which is toxic to liver cells. Subsequently, a complex is prescribed therapeutic measures, which will help remove poison and neutralize the body. In medicine, such procedures are called detoxification therapy. Special preparations are used to cleanse the body.

To restore the liver, there are substances that promote rapid and effective regeneration liver cells and their division.

When there are severe necrotic and cirrhotic lesions of liver cells, organotherapy is used, which promotes rapid recovery liver tissues.

Diet for drug-induced hepatitis

The risk group is people who have already had cases in their family chronic diseases liver or hepatitis. Those who have problems with alcohol or constantly take medications to restore one or another organ are at risk.

People who are at risk and those who do not want to have liver problems should take the most the best remedy for prevention. It's about about grass (thistle). It should be noted that all medications that restore liver function are created on the basis of this natural medicine.

In order to prepare the decoction, you need 2 tbsp. l. crushed seeds, pour 0.5 liters of boiling water and leave for 10-12 hours.

After this, strain the broth. Take 100 ml 5 times a day.

In addition, a person diagnosed with drug-induced hepatitis must adhere to a certain diet. The liver is not “friendly” with:

alcohol and nicotine;
stress;
overweight;
sweets and baked goods in large quantities;
spicy foods and spices;
lamb, fatty pork, lard;
smoked products, pickled vegetables and fruits;
canned food;
mushrooms.

The diet should be based on products with:

maximum reduced level cholesterol and fat;
lots of fiber, vegetables and fruits.

For chronic (drug-induced) hepatitis, doctors recommend:

avoid trans fats (margarine, fat, fast food, crackers, canned food);
reduce as much as possible the consumption of foods that contain saturated fats (butter, ice cream, homemade milk, fried foods);
try to eat as many fresh vegetables and fruits as possible (but replacing them with juices or dried fruits is not recommended);
eat whole grain products, vegetable proteins, legumes;
eat chicken, pigeon, rabbit, veal, lean and unsalted fish;
consume less sugar, salt;
drink at least 2 liters of liquid per day;
don't starve;
eat boiled or baked foods.