Xefocam tablets or injections, which is better? Tablets "Ksefokam": analogues and reviews

Xefocam(lornoxicam) is an analgesic and anti-inflammatory agent. The anti-inflammatory effect of lornoxicam is associated with the ability to inhibit the synthesis of prostaglandins by inhibiting the activity of cyclooxygenase isoenzymes. It also inhibits the release of peroxidation products (free radicals) by activated leukocytes.

The analgesic effect is not associated with narcotic effects. Does not affect opioid receptors of the central nervous system or respiratory function. It is not addictive and does not cause drug dependence.
After oral administration, it is almost completely and rapidly absorbed from the gastrointestinal tract. Cmax is observed after 1-2 hours, in the case of parenteral administration - after 15 minutes. Bioavailability is 90-100%. The connection with the albumin fraction of proteins is 99%, which does not depend on the level of the drug in the blood.

Metabolite xefocama– hydroxylated lornoxicam – has no pharmacological effect. In the body, the drug is completely metabolizable. In blood plasma, lornoxicam is mainly present in the active form and not in the form of a metabolite.
The half-life of lornoxicams does not depend on the level of drug concentration and is 4 hours. Metabolic products are excreted in urine (33%), the rest in bile. In gerontological patients, people with liver and kidney failure, the pharmacokinetic properties of lornoxicam do not change.

Indications for use

It is used for moderate to severe pain (muscle pain, radicular pain, spinal pain, postoperative period), inflammatory and degenerative diseases of the musculoskeletal system (rheumatic lesions). For acute pain (lumbar ischialgia), injuries and in the postoperative period, parenteral (i.m.) administration of the drug is indicated.

Mode of application

The tablets are taken orally, before meals, with water. If the severity of pain is moderate to severe, 8-16 mg/s is prescribed (divided into 2-3 doses). For pathologies of a rheumatic nature, an initial dose of 12 mg 2-3 r/s is prescribed, then the dose is reduced to 8-16 mg/s in 2-3 doses. The duration of treatment is determined individually and depends on the course of the disease and the nature of the pain syndrome.

Patients with impaired function of the gastrointestinal tract, kidneys and liver, gerontological patients (over 65 years old) are prescribed a maximum daily dose of 12 mg (3 times 4 mg).
Parenteral (intramuscular, intravenous) administration xefocama used in case of acute pain syndrome (postoperative period, ischalgia, lumbago). The initial dose is 8-16 mg. In case of insufficient analgesic effect, 8 mg of the drug can be re-administered at the same dose. The maximum daily dose is 16 mg per day. Maintenance dosage – 8 mg 2 times a day.
No dose adjustment is required for patients with low body weight (less than 50 kg), patients with gastrointestinal diseases, and renal and hepatic insufficiency.

Before parenteral administration of the drug, 8 mg of dry substance should be dissolved in 2 ml of water for injection. The prepared solution is injected into a muscle or vein. The shelf life of the prepared solution is no more than 24 hours. When administered into a vein, the duration of the injection should be at least 15 seconds, intramuscularly - at least 5 seconds.

Side effects

Hematopoietic system: thrombocyto-, leukopenia (rare).
Central nervous system: headache, drowsiness, dizziness, insomnia, agitation, hallucinations, aseptic meningitis, migraine, syncope, peripheral neuropathy.
Sense organs: tinnitus, decreased hearing acuity, blurred vision, conjunctivitis.
Endocrine system: chills, fluctuations in body weight, sweating.
Cardiovascular system: increased blood pressure, peripheral edema, palpitations.
Gastrointestinal tract: dyspeptic symptoms (flatulence, abdominal pain, nausea, vomiting, dysphagia), peptic ulcers, bleeding (rectal and intestinal), dry mouth, hepatitis, stomatitis, colitis, glossitis, pancreatitis, changes in liver function.
Urinary system: dysuric phenomena, nephrotic syndrome, crystalluria, glomerulonephritis, papillary necrosis, polyuria, renal failure.
Allergic reactions: rash, bronchospasm, shortness of breath, palpitations, exfoliative dermatitis, Steven-Johnson syndrome, angiitis, lymphadenopathy, allergic rhinitis.

Contraindications

hypersensitivity reactions to lornoxicam or other ingredients of the drug;
hypersensitivity or allergy to other non-steroidal anti-inflammatory drugs (ibuprofen, acetylsalicylic acid, indomethacin);
bleeding disorders (hemorrhagic diathesis);
acute ulcers of the stomach and/or duodenum, nonspecific ulcerative colitis in the acute stage;
significant impairment of liver function;
kidney disease with creatinine clearance 300 µmol/l;
dehydration, hypovolemia;
hemorrhagic stroke;
bronchial asthma;
deficiency of glucose-6-phosphate dehydrogenase;
hearing loss;
age under 18 years;
heart failure.

Pregnancy

Lornoxicam is contraindicated for use in pregnant and breastfeeding women.

Interaction with other drugs

In combination with platelet aggregation inhibitors and anticoagulants, the risk of bleeding and/or bleeding may increase.
Lornoxicam, when combined with sulfonylurea derivatives, potentiates the hypoglycemic effect of the latter.

When combined with non-steroidal anti-inflammatory drugs or glucocorticosteroids, the risk of gastrointestinal side effects increases. Lornoxicam enhances the effects of fibrinolytics.
Xefocam weakens the hypotensive effect of beta-adrenergic receptor blockers, the diuretic and hypotonic effect of diuretics, angiotensin-converting factor inhibitors.
Nephrotoxic drugs (gold drugs, paracetamol, cyclosporine and others) provoke an increased likelihood of developing side effects from the kidneys.

Taking alcohol, corticotropin, and potassium-containing drugs increases side effects on the gastrointestinal system.
Simultaneous use of valproic acid and cephalosporins increases the likelihood of bleeding.

The concentration of lithium in the blood may increase with the simultaneous use of lithium and lornoxicam (this results in toxic side effects of lithium).
When taken simultaneously with digoxin, renal clearance decreases. When combined with methotrexate, the content of the latter in the blood plasma increases.

Overdose

In case of overdose, the side effects of lornoxicam increase. Therapy is symptomatic. Enterosorbents (activated carbon) reduces the likelihood of developing overdose symptoms if taken immediately.

Release form

Tablets 4; 8 mg, 10 pcs. in a blister.
Lyophilized powder 8 mg in a bottle for preparing a solution (complete with solvent - 2 ml).

Storage conditions

Shelf life – no more than 5 years. Store tablet forms out of the reach of children, at a temperature of 15 to 25°C. Store the powder for preparing the injection form in a place protected from light and moisture at a temperature of no more than 25°C. After dissolution, the drug can be used within 24 hours.

Synonyms

Lornoxicam

Compound

Xefocam tablets:
active ingredients: lornoxicam – 4 or 8 mg per tablet;
inactive ingredients: magnesium stearate, croscarmellose sodium, lactose, polyvidone K25, cellulose, talc, hypromellose, titanium dioxide.

Xefocam bottles– 8 mg as lyophilized powder.

Additionally

In case of arterial hypertension and/or anemia, before prescribing the drug, it is recommended to carefully evaluate all possible risks and benefits, since gastrointestinal bleeding, peptic ulcers, and the development of diabetes mellitus with impaired renal function are possible.
If necessary, admission xefocama Patients with gastrointestinal ulcers require additional prescription of H2 receptor blockers, omeprazole.

When using Xefocam for a long time, you should be aware that the healing process of peptic ulcers will be inhibited. If bleeding develops, you must immediately stop taking the drug and prescribe adequate therapy and emergency treatment. Careful medical monitoring is required for patients with gastrointestinal pathology who take xefocam(especially for the first time).

When prescribed to patients with bleeding disorders or when used in combination with heparin (or other agents that reduce blood clotting), monitoring of blood clotting parameters and bleeding time is necessary.
In case of hypovolemia, it can be used only against the background of adequate hydration (otherwise there is a risk of decreased renal perfusion).

If signs of nephropathy develop (arterial hypertension, edema, increased creatinine and urea in the blood serum), the drug should be discontinued (threat of developing papillary necrosis, glomerulonephritis, acute renal failure).
In elderly patients, patients with arterial hypertension, obesity, persons receiving diuretics, nephrotoxic drugs, it is necessary to monitor renal function and blood pressure.

With prolonged use xefocama It is recommended to periodically conduct a clinical blood test, kidney and liver tests.
While taking Xefocam, you should not drink alcohol, drive a car, or be involved in work that requires quick psychomotor reactions.

Main settings

Name:	XEFOCAM
ATX code:	M01AC05 -

With exacerbation of osteochondrosis, attacks of arthralgia, diseases of the spine, even strong tablets and ointments do not completely relieve pain. Inflammation, destruction of intervertebral discs, constant friction of structures provokes a pronounced pain syndrome, which can only be dealt with by formulations for parenteral use.

An effective drug for relieving painful symptoms of osteochondrosis is Xefocam injections. Instructions for use indicate the main points associated with injections, side effects, single and daily dosage, and permitted course duration.

Compound

Xefocam injections are a lyophilisate for preparing a solution. Lornoxicam is the active ingredient of a powerful analgesic. Based on the lyophilisate, the health worker prepares a composition for jet administration. Additional substances include mannitol, trometamol, and other components.

The drug is placed in dark glass bottles. First aid kits receive package No. 5.

Xefocam injections are a potent pain reliever with frequent side effects. In case of exacerbation due to rheumatic diseases and osteochondrosis, a short course of injections of the drug Xefocam is first given, then the patient takes tablets to reduce the negative effect on the body while maintaining a sufficient therapeutic effect.

Action

The analgesic effect is the result of lornoxicam's effect on the production of prostaglandins. Fat-like components activate various types of inflammatory processes and provoke pain. The active substance of the non-narcotic analgesic blocks cyclooxygenase isoenzymes, the production and formation of inflammatory mediators stops quite quickly. The result is stopping the inflammatory process.

The powerful analgesic effect of the drug Xefocam manifests itself with double exposure:

blocking the transmission of pain impulses from the affected area;
decrease in the strength of pain perception in the brain.

Therapeutic drug after Xefocam injections:

elimination of pain syndrome;
pronounced analgesic effect over a long period;
suppression of inflammation.

On a note! Advantages of the drug Xefocam: does not produce an opiate-like effect, does not form addiction and dependence, as with injections of narcotic analgesics. The drug does not cause persistent constipation and does not inhibit the activity of the respiratory center.

Indications for use

The powerful analgesic Xefocam is used to relieve pain in many diseases. Indications include not only damage to the musculoskeletal system, rheumatic diseases, but also other types of pathologies with pronounced pain syndrome.

A drug based on lornoxicam is prescribed in the following cases:

relief of painful manifestations during exacerbation of gout, bursitis, arthritis, osteoarthritis, arthralgia;
elimination of painful manifestations of dental, headache, migraine, and sciatica pain;
reduction of discomfort in systemic lupus erythematosus;
pain relief for extensive burns;
relief of ankylosing spondylitis;
the need for rapid pain relief in the postoperative period.

Contraindications

It is strictly forbidden to use Xefocam without medical permission. This potent drug has many limitations; dose adjustment is required depending on the identified pathologies. Violation of the requirements of the instructions provokes negative phenomena; in case of overdose, a negative effect on the gastrointestinal tract, nervous system, kidneys, and liver is possible.

Xefocam injections are not prescribed if there are restrictions:

ulcerative nonspecific colitis;
pregnancy;
negative reaction to lornoxicam or additional substances;
bronchial asthma;
liver or kidney failure (severe form);
hypersensitivity to components of NSAID drugs;
exacerbation of peptic ulcer;
lactation period;
damage to the hearing organs;
the patient's age is under 18 years;
hemorrhagic diathesis;
low blood clotting;
development of hemorrhagic stroke;
damage to the heart muscle.

Instructions for use and dosage

The solution for injection is prepared before using the drug. It is not advisable to keep the composition in the refrigerator, although the instructions indicate the possibility of storing the composition throughout the day. After this period, the drug cannot be used.

To dilute the lyophilisate, use liquid from the bottle placed in the package. If the composition is not available, you can purchase special water for injection at the pharmacy. Substitutes are saline solution, novocaine or lidocaine. It is important to ensure that the powder is completely dissolved. The ready solution for intramuscular or intravenous administration is yellow.

for rapid pain relief during an attack, a double dose of analgesic 16 mg is initially administered;
maintenance dosage - 1 bottle (8 mg). The drug is administered twice a day;
maximum dosage for 24 hours - 2 bottles or 16 mg;
For elderly patients, doctors recommend a reduced dosage - half the daily norm: initially - 8 mg, maintenance dose - twice a day, 4 mg;
injections of the drug Xefocam are prescribed for a short course - from three to seven days. When relieving acute pain, you need to replace injections with tablets of a powerful analgesic.

Important! A healthcare worker must give injections of a powerful painkiller: the drug requires careful handling and strict adherence to the rules for administering the composition. The doctor decides whether to give injections intramuscularly or intravenously.

Overdose

Violation of the one-time or daily norm provokes severe reactions:

development of liver and kidney failure;
problems with coordination of movements;
convulsive syndrome;
risk of bleeding;
dizziness, loss of consciousness;
severe nausea, vomiting.

Possible side effects

A powerful analgesic quickly relieves pain, but often has a negative effect on different parts of the body. The instructions prohibit uncontrolled use of the drug to avoid severe reactions.

Possible side effects due to injections of the drug Xefocam:

sleep disturbance;
excessive excitement or drowsiness, inhibition of reactions;
depression;
violation of speech functions;
digestive disorders;
stomach pain, nausea, vomiting;
inflammation of the colon;
flatulence;
constipation or diarrhea;
inflammation of the pancreas;
irritation of the oral mucosa, esophagus and stomach;
neuropathy causing motor problems;
deterioration of hearing acuity, feeling of constant tinnitus;
bleeding in parts of the gastrointestinal tract;
hallucinations;
short-term loss of consciousness due to decreased muscle tone;
headaches, including migraines, dizziness.

Go to the address and read about the probable causes of development and treatment features of deforming spondyloarthrosis of the thoracic spine.

Drug interactions

Complex therapy is possible only after analyzing possible adverse reactions and determining the patient’s health status. It is not advisable to combine Xefocam with NSAIDs, antihypertensive, antithrombosis compounds, antidepressants, blood sugar control compounds, and diuretics.

Price

The approximate price of Xefocam injections is from 700 to 760 rubles. The package contains 5 bottles of 8 mg each.

The shelf life of the analgesic is 5 years. Keep bottles with lyophilisate in a dry place, in closed packaging. Temperature - up to +25 C.

Ksefokam: analogues

To relieve pain and suppress prostaglandin synthesis, other names of the NSAID group with active analgesic and anti-inflammatory effects are used:

Liberum.
Amelotex.
Meloflex Rompharm.
Movalis.
Tesamen.
Mesipol.
Melbek and Melbek-Forte.

From this medical article you can familiarize yourself with the drug Xefocam. The instructions for use will explain in what cases you can take tablets and injections, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Xefocam, from which you can find out whether the medicine helped in the treatment of various types of pain syndrome in adults and children. The instructions list analogs of Xefocam, prices of the drug in pharmacies, as well as its use during pregnancy.

The non-steroidal anti-inflammatory drug is Xefocam. Instructions for use recommend taking 4 mg and 8 mg Rapid tablets, injections in injection ampoules for short-term treatment of moderate to severe pain; for inflammatory and degenerative diseases of the musculoskeletal system.

Release form and composition

Pharmacies supply coated tablets of 4 mg and 8 mg (Xefocam Rapid).

The instructions indicate that the second dosage form is a lyophilisate for the preparation of a solution for intravenous and intramuscular administration (injections in injection ampoules).

The active substance is lornoxicam. Its volume in tablets reaches 4 or 8 mg. Lifilizate contains 8 mg of the active ingredient in a bottle.

pharmachologic effect

The drug has an analgesic and anti-inflammatory effect. The anti-inflammatory effect of lornoxicam is due to inhibition of the activity of cyclooxygenase isoenzymes, which inhibits the synthesis of prostaglandins. Xefocam, the instructions for use confirm this, suppresses the release of free radicals by activated leukocytes.

The analgesic effect of the drug is not associated with narcotic effects. The drug does not affect the opioid receptors of the central nervous system, does not depress respiration, and does not cause addiction or drug dependence.

The active substance is quickly absorbed from the gastrointestinal tract and completely metabolized in the liver. The drug is excreted in the form of metabolites, mostly with bile, partly by the kidneys.

What does Xefokam help with?

Indications for use of the drug include:

symptomatic treatment of rheumatoid arthritis and osteoarthritis;
short-term treatment of pain in injuries and after surgery;
sciatica;
algodismenorrhea.

Instructions for use

Xefocam tablets are taken orally. They contain 4 mg or 8 mg of lornoxicam.

For rheumatic diseases, as well as for maintenance therapy, the instructions recommend taking the drug Xefocam twice a day, 4-8 mg, depending on the patient’s well-being.

For moderate or severe pain, 16 mg of the drug is prescribed per day, divided into two doses. On the first day of treatment, if necessary, an additional 16 mg may be used.

Xefocam injection solution can be administered intravenously (at least 15 seconds) and intramuscularly (at least 5 seconds). To prepare a solution for injection, take 8 mg of dry powder and dilute it in 2 ml of solvent.

Injections are used for acute pain syndrome: the recommended dose is 8 mg; if the analgesic effect is insufficient, 8 mg of the drug is repeated. Maintenance therapy involves the use of Xefocam 2 times a day, 8 mg.

For patients with renal or liver failure, diseases of the digestive tract, and with a body weight of less than 50 kg, no dose adjustment is required.

Contraindications

children and adolescents under 18 years of age (due to the lack of clinical data on the use of the drug in this age group);
complete or incomplete combination of bronchial asthma, recurrent nasal polyposis or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including a history);
pregnancy;
breastfeeding period;
thrombocytopenia;
hypersensitivity or allergy to the components of the drug Xefocam, from which tablets and injections can cause side effects;
liver failure or active liver disease;
inflammatory bowel diseases (Crohn's disease, UC) in the acute phase;
heart failure in the stage of decompensation;
severe renal failure (serum creatinine more than 300 µmol/l), progressive kidney disease, confirmed hyperkalemia, hypovolemia or dehydration;
hemorrhagic diathesis or bleeding disorders, as well as after operations involving the risk of bleeding or incomplete hemostasis;
recurrent stomach ulcer or repeated bleeding from the gastrointestinal tract;
data on previous gastrointestinal bleeding associated with taking NSAIDs;
erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding; cerebrovascular or other bleeding;
period after coronary artery bypass surgery.

Side effects

Children, pregnancy and breastfeeding

Xefocam is not prescribed to pregnant and lactating women. Should not be used by women planning pregnancy. The medication is contraindicated for children under 18 years of age.

special instructions

Caution should be exercised when treating patients who smoke and abuse alcohol with Xefocam.

In the case of arterial hypertension or anemia, before using the medicine, it is necessary to weigh the possible risks and benefits of therapy, since the development of gastrointestinal bleeding, peptic ulcers, diabetes mellitus with impaired renal function is possible.

Long-term use of lornoxicam slows down the healing of peptic ulcers. In case of bleeding, it is necessary to stop taking the drug and apply adequate therapy.

Drug interactions

In combination with anticoagulants or platelet aggregation inhibitors, bleeding time may increase. Therefore, MHO control is required.

In combination with beta-blockers and ACE inhibitors, their hypotensive effect may be reduced. In combination with diuretics, the diuretic effect and hypotensive effect are reduced.

Analogues of the drug Xefocam

In terms of structure, the drug Xefocam Rapid is analogous. Analogs are distinguished by pharmacogroup:

Vacation conditions and price

The average price of Xefocam (4 mg tablets No. 10) in Moscow is 117 rubles. In Kyiv you can buy medicine for 55 hryvnia, in Kazakhstan - for 660 tenge. In Minsk, pharmacies offer the drug for 8-9 bel. rubles Dispensed from pharmacies with a prescription.

Indications for use:
It is used for moderate and severe pain syndrome (muscle pain, radicular pain, pain in the spine, during the postoperative period), inflammatory and degenerative diseases of the musculoskeletal system (rheumatic lesions). For acute pain (lumbar ischialgia), injuries and during the post-operative period, parenteral (i.m.) administration of the product is indicated.

Pharmachologic effect:
Xefocam (lornoxicam) is an analgesic and anti-inflammatory drug. The anti-inflammatory effect of lornoxicam is associated with the ability to inhibit the synthesis of prostaglandins by inhibiting the activity of cyclooxygenase isoenzymes. It also inhibits the release of peroxidation products (free radicals) by activated leukocytes.

The metabolite of xefocam, hydroxylated lornoxicam, has no pharmacological effect. The product is completely metabolizable in the body. In blood plasma, lornoxicam is mainly present in the active form and not in the form of a metabolite.
The half-life of lornoxicams does not depend on the concentration level of the product and is 4 hours. Metabolic products are excreted in urine (33%), the rest in bile. In gerontological patients, people with liver and kidney failure, the pharmacokinetic properties of lornoxicam do not change.

Xefocam method of administration and dosage:
The tablets are taken orally, before meals, with water. If the severity of pain is moderate to severe, 8-16 mg/s is prescribed (divided into 2-3 doses). For pathologies of a rheumatic nature, an initial dose of 12 mg 2-3 r/s is prescribed, then the dose is reduced to 8-16 mg/s in 2-3 doses. The duration of treatment is determined individually and depends on the course of the disease and the nature of the pain syndrome.

Patients with impaired function of the gastrointestinal tract, kidneys and liver, gerontological patients (over 65 years old) are prescribed a maximum daily dose of 12 mg (3 times 4 mg).
Parenteral (intramuscular, intravenous) administration of xefocam is used in case of acute pain syndrome (subsequently during the surgical period, ischalgia, lumbago). The initial dose is 8-16 mg. In case of insufficient analgesic effect, 8 mg of the product can be re-administered at the same dose. The maximum daily dose is 16 mg per day. Maintenance dosage – 8 mg 2 times a day.
No dose adjustment is required for patients with low body weight (less than 50 kg), patients with gastrointestinal diseases, and renal and hepatic insufficiency.

Before parenteral administration of the product, 8 mg of dry substance should be dissolved in 2 ml of water for injection. The prepared solution is injected into a muscle or vein. The storage period for the prepared solution is no more than 24 hours. When administered into a vein, the duration of the injection must be at least 15 seconds, intramuscularly - at least 5 seconds.

Xefocam contraindications:
hypersensitivity reactions to lornoxicam or other ingredients of the product;
hypersensitivity or allergy to other non-steroidal anti-inflammatory drugs (ibuprofen, acetylsalicylic acid, indomethacin);
bleeding disorders (hemorrhagic diathesis);
acute ulcers of the stomach and/or duodenum, nonspecific ulcerative colitis in the acute stage;
significant impairment of liver function;
kidney disease with creatinine clearance 300 µmol/l;
dehydration, hypovolemia;
hemorrhagic stroke;
bronchial asthma;
deficiency of glucose-6-phosphate dehydrogenase;
hearing loss;
age under 18 years;
heart failure.

Xefocam side effects:
Hematopoietic system: thrombocyto-, leukopenia (not often).
Central nervous system: headache, drowsiness, dizziness, insomnia, agitation, hallucinations, aseptic meningitis, migraine, syncope, peripheral neuropathy.
Sense organs: tinnitus, decreased hearing acuity, blurred vision, conjunctivitis.
Endocrine system: chills, fluctuations in body weight, sweating.
Cardiovascular system: increased blood pressure, peripheral edema, palpitations.
Gastrointestinal tract: dyspeptic symptoms (flatulence, abdominal pain, nausea, vomiting, dysphagia), peptic ulcers, bleeding (rectal and intestinal), dry mouth, hepatitis, stomatitis, colitis, glossitis, pancreatitis, changes in liver function.
Urinary system: dysuric phenomena, nephrotic syndrome, crystalluria, glomerulonephritis, papillary necrosis, polyuria, renal failure.
Allergic reactions: rash, bronchospasm, shortness of breath, palpitations, exfoliative dermatitis, Steven-Johnson syndrome, angiitis, lymphadenopathy, allergic rhinitis.

Pregnancy:
Lornoxicam is contraindicated for use in pregnant and breastfeeding women.

Overdose:
In case of overdose, the side effects of lornoxicam increase. Therapy is symptomatic. Enterosorbents (activated carbon) reduce the likelihood of developing overdose symptoms if taken immediately.

Use with other medications:
In combination with platelet aggregation inhibitors and anticoagulants, the risk of bleeding and/or bleeding may increase.
Lornoxicam, when combined with sulfonylurea derivatives, potentiates the hypoglycemic effect subsequently.

When combined with non-steroidal anti-inflammatory products or glucocorticosteroids, the risk of gastrointestinal side effects increases. Lornoxicam enhances the effects of fibrinolytics.
Xefocam weakens the hypotensive effect of beta-adrenergic receptor blockers, the diuretic and hypotonic effect of diuretics, and angiotensin-converting factor inhibitors.
Nephrotoxic products (gold products, paracetamol, cyclosporine and others) provoke an increase in the likelihood of developing side effects from the kidneys.

Taking alcohol, corticotropin, and potassium-containing products increases side effects on the gastrointestinal system.
Simultaneous use of valproic acid and cephalosporins increases the likelihood of bleeding.

Lithium concentrations may increase in the blood when lithium products and lornoxicam are used simultaneously (this results in toxic side effects of lithium).
When taken simultaneously with digoxin, renal clearance decreases. When combined with methotrexate, the content of the drug in the blood plasma increases.

Release form:
Tablets 4; 8 mg, 10 pcs. in a blister.
Lyophilized powder 8 mg in a bottle for preparing a solution (complete with solvent - 2 ml).

Storage conditions:
Storage period – no more than 5 years. Store tablet forms out of the reach of children, at a temperature of 15 to 25°C. Store the powder for preparing the injection form in a place protected from light and moisture at a temperature of no more than 25°C. After dissolution, the product can be used throughout the day.

Synonyms:
Lornoxicam

Xefocam composition:
Xefocam tablets:
active ingredients: lornoxicam – 4 or 8 mg per tablet;
inactive ingredients: magnesium stearate, croscarmellose sodium, lactose, polyvidone K25, cellulose, talc, hypromellose, titanium dioxide.

Xefocam bottles – 8 mg in the form of lyophilized powder.

Additionally:
In case of arterial hypertension and/or anemia, before prescribing the product, it is recommended to carefully evaluate all possible risks and benefits, since gastrointestinal bleeding, peptic ulcers, and the development of diabetes mellitus with impaired renal function are possible.
If patients with gastrointestinal ulcers need to take Xefocam, additional prescription of H2 receptor blockers and omeprazole is necessary.

When using Xefocam for a long time, you should be aware that the healing process of peptic ulcers will be inhibited. If bleeding develops, you must immediately stop taking the product and prescribe adequate therapy and emergency treatment. Careful medical supervision is required for patients with gastrointestinal pathology who are taking Xefocam (especially for the first time).

When prescribed to patients with bleeding disorders or when used in combination with heparin (or other drugs that reduce blood clotting), monitoring of blood clotting parameters and bleeding time is necessary.
In case of hypovolemia, it can be used only against the background of adequate hydration (otherwise there is a risk of decreased renal perfusion).

If signs of nephropathy develop (arterial hypertension, edema, increased creatinine and urea in the blood serum), the product should be discontinued (threat of developing papillary necrosis, glomerulonephritis, acute renal failure).
In elderly patients, patients with arterial hypertension, obesity, persons receiving diuretics, nephrotoxic products, it is necessary to monitor renal function and blood pressure.

With prolonged use of Xefocam, it is recommended to periodically conduct a clinical blood test, kidney and liver tests.
While taking Xefocam, you should not drink alcohol, drive a car, or be involved in work that requires quick psychomotor reactions.

Attention!
Before using the medication "Xefocam" You should consult your doctor.
The instructions are provided for informational purposes only. Xefocam».

22 reviews

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I had to interrupt treatment due to skin rashes and stomatitis on the tongue. When used, the pain goes away, and when the effect of the drug wears off, you feel like Cinderella after midnight. Everything falls into place and the pain returns.

Xefocam relieved pain well after a rib injury or neuralgia, BUT after that the leg on the injection side was very sore. I won’t put it on again, I’m afraid my leg will completely fall off.

I am 71 years old. Chronic spondylosis, arthritis, intervertebral hernia (3 pieces). Chronic pain. Recently there was an aggravation. On the recommendation of a doctor, I tried several drugs (intramuscularly) until we tried Xefocam. Literally in one go - an excellent result! We had 5 injections - everything was fine. The pain went away, I haven’t noticed any side effects (yet).

My mother has a diseased spine, they went to the hospital and took an x-ray, they said it was normal khandoros, they prescribed her xefocam and combilipen. She was injected with Xefocam for 3 days and her stomach began to hurt very badly, and on the fourth day after the injections her blood pressure dropped sharply and she fainted.

My mother has gangrene of the lower extremities, the doctor prescribed Xefocam. I don’t know if it will help or not? She is in very bad pain

I have frequent severe pain in the spine and a postoperative hernia. And then the sciatic nerve was pinched. The neurologist prescribed Xefocam intramuscularly. Of course, the drug has a strong analgesic effect. Within a week of use, the pain completely disappeared. But Xefokam is not a cheap drug, I ordered it through the ASNA program https://www.asna.ru/catalog/ksefokam_4mg_n30_tab_pokrytye_plenochnoy_obolochkoy_takeda.html. This results in huge savings if... I have frequent severe pain in the spine and a postoperative hernia. And then the sciatic nerve was pinched. The neurologist prescribed Xefocam intramuscularly. Of course, the drug has a strong analgesic effect. Within a week of use, the pain completely disappeared. But Xefokam is not a cheap drug, I ordered it through the ASNA program https://www.asna.ru/catalog/ksefokam_4mg_n30_tab_pokrytye_plenochnoy_obolochkoy_takeda.html. You get huge savings if you order any medicines worth 3,000 rubles or more along with Xefocam.

I was prescribed a drug for severe pain in the spine (Schmorl's hernia, protrusion, arthrosis of the lumbocostal joints). It became a little easier on the 5th day; on the 9th day of taking the drug (intramuscularly), severe pain in the stomach appeared (exacerbation of the ulcer). As the saying goes. - we treat one thing, and cripple the other.

I started having terrible pain in my spine, to the point where I had to call an ambulance. After the examination, I was told that I had a hernia. The main treatment was prescribed, and Xefocam was prescribed for pain relief. The drug is very good as a pain reliever. But you can’t take it for a long time, it gives side effects. I took it for a week, then it became easier.... I started having terrible pain in my spine, to the point where I had to call an ambulance. After the examination, I was told that I had a hernia. The main treatment was prescribed, and Xefocam was prescribed for pain relief. The drug is very good as a pain reliever. But you can’t take it for a long time, it gives side effects.
I took it for a week, then it became easier.
Ksefokam is now always at hand, just in case.

Today we took an x-ray of the lumbar region. Displacement of the disc vertebrae was discovered. Before that, on Monday I had an appointment and was prescribed injections of Artrosan, Midakam and Combilepene. Until today I have received 5 injections. There are no improvements. And in the evening we made xefocam. I thought I was going to die. There was such pain, it burned like fire, as if they were cutting someone alive. Still... Today we took an x-ray of the lumbar region. Displacement of the disc vertebrae was discovered. Before that, on Monday I had an appointment and was prescribed injections of Artrosan, Midakam and Combilepene. Until today I have received 5 injections. There are no improvements. And in the evening we made xefocam. I thought I was going to die. There was such pain, it burned like fire, as if they were cutting someone alive. It still doesn’t subside, to the point of tears. I don’t know how I’ll sleep at night.