Maxitrol eye drops and ointment. Maxitrol eye drops Maxitrol eye drops instructions for use

Maxitrol is a combined topical ophthalmic drug produced in Belgium. The product can be used to treat infectious eye diseases, as well as to correct damage to the adnexa after medical procedures. If necessary, the use of Maxitrol is possible during pregnancy and lactation, but only if there are strong indications and under the supervision of a specialist. Information on the price of Maxitrol eye drops, as well as instructions for use, can be found on the Internet, but only the attending physician should carry out diagnostics and prescribe a dosage regimen.

Compound

Maxitrol eye drops are a medicinal product containing a combined formula of active ingredients, which is based on three components:

neomycin is an antibiotic produced in the form of sulfate and belonging to the group of aminoglycosides (3500 units per 1 ml);
dexamethasone - a glucocorticosteroid with anti-inflammatory and antiallergic effects (1 mg per 1 ml);
polymyxin (in the form of polymyxin B sulfate) is an antibacterial component that reduces the permeability of the membrane membrane of bacterial cells.

The drug has a wide spectrum of antibacterial activity and is effective against infectious eye diseases caused by Haemophilus influenzae, aerobic bacteria, staphylococcus, Klebsiella and other types of gram-negative and gram-positive microorganisms.

The use of Maxitrol for diseases caused by streptococci is unjustified, since neomycin has weak activity against these pathogens, and its use can provoke the development of superinfection against the background of secondary infection of eye components.

The presence of dexamethasone in the composition allows the medicine to be used for pathologies accompanied by inflammatory processes in the conjunctiva, cornea or retina. The product has an anti-inflammatory effect, eliminates the manifestations of an allergic reaction, and prevents the accumulation of exudate (fluid released from damaged blood vessels during inflammatory processes) in the eye cavity.

Dexamethasone promotes desensitization (reduced sensitivity) in patients of the older age group and reduces the risk of developing an infectious process.

Release form

Maxitrol (Latin name - Maxitrol) is available in two dosage forms:

solution for instillation into the conjunctival sac in the form of eye drops (in 5 ml bottles with a dispenser attachment);
eye ointment (in tubes of 3.5 g).

The drug can be stored in the refrigerator (at a temperature not lower than +8°) or at room temperature (up to 30°) for two years. Storage in a horizontal position is not allowed. After opening the package, the medicine can be stored for four weeks. The bottle must be shaken before use.

Indications for use

Instructions for use of Maxitrol eye drops recommend using the product for infectious lesions of the components of the eye and its appendages.

The drug can be prescribed after surgery to prevent inflammation and possible infection, which often occurs against the background of reduced local immunity. This is especially true for elderly patients, since the duration of the recovery period for them is almost 2 times longer than for patients of the middle age group.

Indications for the use of Maxitrol may include the following diseases:

chronic inflammation of the eyelids with the formation of purulent discharge (blepharitis);
infectious inflammation of the cornea, leading to clouding of the cornea, intense pain and the formation of ulcerative defects (keratitis);
bacterial infections of the mucous membrane (conjunctivitis);
inflammation of the choroid and iris (iridocyclitis).

Maxitrol is also effective for combined infections, for example, keratoconjunctivitis, which often occurs in patients over 50-55 years of age with weakened immune systems.

Side effects

Reviews of Maxitrol eye drops suggest that the drug is quite well tolerated, however, in some cases side effects may occur. Negative reactions during treatment with the drug are most often caused by the content of dexamethasone. If Maxitrol is prescribed for more than 10 days, regular monitoring of intraocular pressure is required, since there is a high probability of damage to the optic nerve. Other side effects of topical corticosteroids include:

visual field defects that occur against the background of a sharp increase in intraocular pressure (glaucoma);
opacification of the posterior wall of the lens of the subcapsular type (posterior cataract);
thinning of the cornea and ocular sclera with possible perforation (violation of integrity).

Maxitrol reduces the effectiveness of wound healing and regenerating drugs, so their simultaneous administration is not recommended.

Superinfection during treatment with Maxitrol

Superinfection is a fairly rare complication of combination therapy, but the possibility of its occurrence cannot be completely excluded. The main factors contributing to secondary infection by bacteria or fungi are a stable decrease in the activity of immune cells and thinning of the cornea, which often occurs during long-term (more than 10 days) treatment with topical steroid drugs.

The risk of developing superinfection is higher in patients over 45-50 years of age, people with systemic chronic diseases, autoimmune disorders, and those living in unfavorable social, living and sanitary conditions. If signs of a secondary infection are detected, treatment with Maxitrol must be stopped and another antibacterial drug must be selected, taking into account the identified pathogen and its resistance to antibiotics.

Contraindications

Maxitrol contains only antibacterial components, so the product is ineffective in the treatment of viral and fungal eye infections. Treatment with the drug is contraindicated for herpes zoster, a viral disease manifested by characteristic skin rashes and acute pain.

Eye infections caused by mycobacteria (for example, tuberculosis infection) require the use of other antibiotics, since neomycin does not have sufficient activity against this group of microorganisms.

The use of Maxitrol is prohibited for purulent ulceration of the cornea and after surgery to remove a foreign body.

Pregnancy and lactation are not a contraindication for the use of the drug, but treatment in this category of patients must be carried out according to strict indications. No teratogenic or embryotoxic effects on the fetus were detected during treatment of pregnant women.

In pediatric practice, Maxitrol can be used without age restrictions after laboratory diagnosis of biological material (tear fluid).

Instructions for use

The standard dosage regimen for Maxitrol for mild to moderate infections is 1-2 drops every 4-6 hours. Instillations must be carried out on both eyes to prevent infection of healthy tissues. The product should be instilled into the conjunctival sac, tilting your head back and gently moving the edge of the lower eyelid down.

For severe bacterial eye infections, the procedure must be repeated every hour. After the main symptoms have reduced and the patient’s condition has improved, the patient should switch to a standard treatment regimen. The duration of therapy should not exceed 10 days.

Price

The price of Maxitrol eye drops depends on the region and method of sale (in online pharmacies the cost is usually 3-10% lower than in chain pharmacies). The average cost of one bottle is:

in Moscow - 490 rubles;
in St. Petersburg - 472 rubles;
in Yekaterinburg - 513 rubles.

The minimum cost in online pharmacies is 414 rubles per bottle. In Ukraine, the drug can be purchased for 120 hryvnia.

Analogues

Analogues of Maxitrol eye drops may be required if the drug is poorly tolerated, symptoms of an allergy to the components of the drug are detected, or treatment is ineffective. Medicines with similar composition or similar medicinal properties are listed below.

Maxitrol (eye ointment). Maxitrol ointment is an absolute analogue of eye drops with an identical composition. In some regions, the drug has been withdrawn from sale, so it can only be purchased to order.
Dexa-Gentamicin. A combination drug containing dexamethasone and gentamicin in the form of sulfate (antibiotic). Contraindicated in the first trimester of pregnancy and childhood (under 18 years). Available in the form of drops and ointments. The average cost is 126 rubles.
Tobradex. Tobradex eye drops contain dexamethasone and tobramycin (an aminoglycoside antibiotic). Unlike Maxitrol, it has high activity against streptococci. The cost of the medicine starts from 350 rubles.

Changing the drug without consulting a doctor is not allowed.

Redness of the eyes is not always caused by banal overwork. Sometimes the cause of a change in the color of the mucous membrane is one or another disease. The most common is conjunctivitis, an unpleasant ophthalmological ailment that anyone can encounter, regardless of age and gender.

The disease can be both allergic and infectious in nature. Moreover, the latter variety is easily transmitted by contact. Therefore, if you often go to crowded places and forget to wash your hands when you come from the street, then the likelihood of getting such eye inflammation increases many times over.

Also at risk are people who are forced by duty to inhale fumes from varnishes and chemical reagents. They also provoke conjunctivitis.

Even ordinary shampoos and cleaning products, as well as low-quality cosmetics, can cause eye inflammation.

Therefore, it is important to know which drug will help you and your loved ones cope with this disease, which creates not only physical, but also aesthetic discomfort.

Note that Maxitrol eye drops do not just relieve unpleasant symptoms - itching, redness, lacrimation and others. They defeat inflammation and effectively fight infection.

This unique medical drug has both anti-inflammatory and bactericidal effects, has virtually no side effects and has proven itself in the treatment of many ophthalmological problems.

Pay attention! Maxitrol eye drops are available only with a doctor's prescription.

Compound

This medicine contains antibiotics and also dexamethasone. This combination allows you to avoid further infectious development.

Note that Maxitrol is one of the drugs with proven effectiveness.

Components included:

Neomycin. Antibiotic complex. Has antibacterial and bactericidal effects.
Polymyxin B. Antibacterial, bactericidal substance. Active against microorganisms such as Salmonella, Bordetella pertussis, Enterobacter and others.
Dexamethasone. Belongs to the group of glucocorticosteroids (substances similar to natural steroid hormones). Helps relieve inflammation and swelling, as well as relieve allergic symptoms.

Additional components: water, sodium chloride, sodium hydroxide, benzalkonium chloride, hypromelose.

When to use it

Maxitrol eye drops are broad-spectrum drugs and are effective in treating various diseases.

Problem	Description	Main symptoms
Conjunctivitis	A disease characterized by inflammation of the mucous membrane of the eye, allergic or infectious etymology	Redness of the eyes, photophobia, swelling of the eyelids
Blepharitis	Chronic disease of the eyelids, characterized by inflammation; It can be purulent, ulcerative, scaly, seborrheic, etc.	Swelling of the eyelids, itching, redness, eyelash loss
Keratitis	Inflammatory disease of the cornea	Watery eyes, decreased visual acuity, pain
Blepharoconjunctivitis	Inflammatory disease of the mucous membranes of the eyes and eyelids	Swelling and redness of the mucous membrane of the eye and eyelids, photophobia, itching
Keratoconjunctivitis	Inflammatory disease of the mucous membrane and cornea of the eyes	Pain in the eye, redness, itching, lacrimation

If you notice one or several similar symptoms at once, Maxitrol eye drops can help you, including in complex therapy in combination with other ophthalmic drugs. But, of course, you will first need to consult with an ophthalmologist. The effectiveness of treatment of inflammatory eye diseases directly depends on the correctness and timeliness of diagnosis.

This is interesting! Maxitrol drops are also used in otolaryngology. The drug is effective in the treatment of profuse runny nose and otitis media. ATTENTION! If you are using this remedy simultaneously to treat conjunctivitis and otitis media, it is recommended that you use separate bottles for the eyes and ears. Otherwise, there is an increased risk of spreading the infection.

Where to buy and who makes it

Maxitrol eye drops are sold exclusively in pharmacies. Do not buy the drug from your hands! Indeed, in this case it is easy to stumble upon a counterfeit, expired medicine or a medicine that has become useless or even dangerous due to violation of storage conditions.

"Maxitrol" should be stored at a temperature no higher than 30 degrees and no lower than 8 degrees, in a dry place, away from sunlight.

The manufacturer of Maxitrol is the American company Alcon, a recognized leader in the ophthalmological market.

Maxitrol eye drops belong to the middle price range of medicines and are available to a wide range of consumers.

Directions for use and dosage

The drug should be used in strict accordance with the instructions and recommendations of the attending physician.

During the first few days of use, the drug should be instilled, including at night, at intervals of about 2 hours.

Dosage: 1-2 drops in each eye.

As treatment progresses, the number of instillations is reduced to 5-6.

The course lasts from 5 to 7 days. However, in some cases, the doctor decides to increase the duration of the course.

Attention! If you wear contact lenses, you must remove them before using the drug. Re-installation is possible 20 minutes after using Maxitrol.

Video - How to put drops into the conjunctival sac of the eye

Contraindications

Before using these eye drops, you should make sure that they are not contraindicated for you.

You cannot use Maxitrol for:

chickenpox;
tuberculosis;
cataracts (with caution);
glaucoma (with caution);
fungal eye infections;
hypersensitivity to the components of the drug;
purulent infection of the mucous membrane.

Note: no cases of drug overdose have been identified.

Things to remember

If your doctor has prescribed the ophthalmic drug “Maxitrol” for treatment, you should keep in mind that:

after opening the package, these eye drops can be stored for no more than four weeks;
Do not use the drug simultaneously with other medications; you should pause for at least 10 minutes between instillations;
"Maxitrol" - eye drops for adults; in pediatrics, the feasibility and effectiveness of using this drug have not been established;
drops are not recommended for use during lactation;
Treatment of pregnant women - with caution, as prescribed by a doctor.

In addition, when using Maxitrol eye drops, side effects of a predominantly local nature may develop. Thus, the drug can cause allergies, expressed in itching, swelling and redness. If such symptoms occur, you should stop using the drops and consult your doctor.

You should know! When using the drug for a long time - more than 10 days - you should be examined for increased intraocular pressure.

Maxitrol is intended to relieve inflammation of the eyes; it is a combination drug that is applied topically.

Indications for use

As mentioned above, Maxitrol is used to relieve eye inflammation. Indicated in the following cases:

Bacterial inflammation of the eyelids (blepharitis)
Infection of the lining of the eye (conjunctivitis)
Keratitis
Iridocyclitis
Chemical contact with the eyes, burns or mechanical damage
Preventive measures after surgery to prevent possible complications

Compound

The drug contains active ingredients: 1.0 milligrams of dexamethasone, 6000 IU of polymyxin B and 3500 IU of neomycin.

Additional substances: sodium hydroxide, polysorbate 20, sodium chloride, benzalkonium chloride, hypromellosum, distilled water.

Medicinal properties

The effective drug Maxitrol (ointment, drops) relieves inflammation and kills bacteria. The most active ingredient in the product is dexamethasone (corticosteroid). In combination with antimicrobial agents, it stops inflammatory processes. The antibacterial auxiliary component neomycin sulfate has a bactericidal effect. Polymyxin B sulfate has a selective effect, which is aimed at gram-negative bacteria.

Additional components of the drug Maxitrol are easily absorbed in case of injury to eye tissue after external use. The corticosteroids present in the drug are absorbed into the cornea, iris, retina and ciliary body.

Maxitrol drops

Average price: 450 rub.

Maxitrol eye drops are a white or yellowish opaque suspension in a 5 ml bottle with a dropper stopper.

Directions for use and doses

Shake the bottle before using Maxitrol eye drops. For mild forms of the disease, it is recommended to instill 1-2 drops of the drug into the conjunctival sac 4 to 6 times a day. If the infectious process is severe, the drug can be instilled after an hour and a half. To avoid eye infections, do not touch the bottle dispenser. After instillation, the stopper must be tightly closed.

To properly instill Maxitrol eye drops, it is recommended to do the following:

Wash your hands
Throw your head back
Pull back the lower eyelid slightly and look upward
Apply instillation between the eyelid and eye
Close your eyes and press the inner corners for 1-2 minutes.

Ointment "Maxitrol"

Average price: 400 rub.

The eye ointment is opaque, white to light yellow, and the tube holds 3.5 g of product.

Packaging: 1 tube per cardboard box, plus instructions for use.

Directions for use and doses

The ointment is applied behind the eyelid three times a day with a column thickness of 1-1.5 centimeters. Additionally, you can apply the ointment before going to bed. When using the ointment, under no circumstances should you touch the tip of the tube.

Contraindications

Maxitrol (drops, ointment) should not be prescribed to patients who are intolerant to the components of the drug, with eye diseases caused by a viral infection, with ringworm or fungus in the eye area, with infectious diseases with pus discharge.

Special attention is required when prescribing the drug for cataracts or glaucoma.

When using the drug, precautions should be taken. Do not use if your skin is hypersensitive. And during treatment, do not wear lenses.

Pregnancy and lactation period

There is no extensive reliable data on the use of Maxitrol during lactation and pregnancy. It can be used by a pregnant woman, but only the doctor who is seeing her can prescribe it. During breastfeeding, the use of the product is prohibited.

Drug interactions

Studies show that when used in ophthalmology, no interactions of Maxitrol with other drugs have been identified. When using the drug simultaneously with ophthalmic drops or ointments, instillation should be done with a break of 10-15 minutes.

Side effects

Sometimes the use of the drug may be accompanied by concomitant phenomena:

Increased intraocular pressure
Allergy
Corneal perforation

Overdose

Long-term use of Maxitrol in large quantities can cause a number of side effects. In case of overdose, maintenance therapy is required.

If more drops get into the eyes during use than prescribed in the instructions, the mucous membrane must be rinsed with warm water.

Storage conditions and periods

The bottle or tube should be stored at a temperature of 10–30 °C. Preferably away from the sun. Prevent access for children.

Suitability period – 24 months. After opening – 1 month.

Analogues

Synonyms for Maxitrol are:

Manufacturer: E.I.P.I.Co., Egypt.
Price– 400-500 rub.

A drug consisting of three components, Neladex (polymyxin B, glucocorticosteroid and neomycin). Unflavored whitish suspension. The drug has an antibacterial effect and relieves inflammation.

Pros:

Rapidly absorbed
Has a systemic effect.

Cons:

Not recommended for use during pregnancy
When used, a secondary infection may develop.

You came to us, dear user, and you can be sure that you will not regret it. And do you know why? Because our site thinks about you first! We specifically try to present all the information, even the most complex, in such a way that you can understand it as much as possible.

The issues we consider here are very different and we do not want to lose those who regularly use our articles. Therefore, we speak simply and clearly even about diseases and medications. For example, now we will talk about what Maxitrol is, the instructions for use of which can help you decide whether it will cure your problem?

What kind of drug?

Let's first understand the composition and pharmacological properties of this ophthalmic combination product. Let's start with the fact that this drug is quite widely used in ophthalmology. To be a little more specific, it fights inflammatory and infectious processes that occur in the eyes.

Dexamethasone (1 mg) ─ acts against allergies, inflammation and excessive vascular permeability.
Polymyxin B ─ effectively blocks excessive permeability of the membrane (cytoplasmic).
Neomycin sulfate ─ having a bactericidal effect, it prevents protein synthesis in a foreign microbial cell.

The main component that has an effect on the diseased organ is dexamethasone. Maxitrol is used exclusively topically (installations). And if antibiotics are used together with it, the risk of infection is significantly reduced.

Use of the drug

Of course, we have already informed you that Maxitrol has been released as a treatment for eye diseases. But let’s take a closer look at which of them are in his “paraffy”:

keratitis,
conjunctivitis (-kerato-, -blepharo-),
chronic and bacterial blepharitis,
uvitas (iridocyclitis, cyclitis, iritis),
damaged cornea (trauma, radiation, chemicals, foreign bodies, thermal burns).

Can be used in conjunction with antimicrobials if there are too many microorganisms in the eye or there is a high risk of infection. It is also practiced for preventive purposes, in the postoperative period, in the fight against infectious complications.

It is acceptable to treat cataracts and glaucoma, but it is important to be careful when taking it and be careful when using it. Before you start taking medication, be sure to consult your doctor.

How to use Maxitrol

But how is the instillation procedure performed, and in what doses should it be done? It is best to perform all actions strictly according to the instructions and under the supervision of an experienced ophthalmologist. After all, treatment and doses directly depend on how long the disease has dragged on and to what “stage” it has reached. It makes the following recommendations:

Mild form of the disease. 1 or 2 drops of liquid should be instilled directly into the conjunctival sac. Depending on the course of the disease, do this about 4-6 times a day.
Severe form of the disease. In this case, the procedure should be carried out almost every hour, still 1-2 drops.

All treatment should last about 6, and a maximum of 10 days. When instilling, try not to touch the tip of the bottle not only to your eye, but also to any objects around you.

To make this process easier, try to pull back the lower eyelid and look up, then close and press the inner corner of the eye with a cotton swab. This will increase the effect of the drug and reduce some unpleasant side effects.

Side effects

Like any medicine, Maxitrol also has side effects that may affect those who have a particular sensitivity or disease that reacts negatively to the drug. Let's pay attention to them to be extremely careful:

dry eyes,
burning,
redness,
painful sensations,
feeling of the presence of a foreign body,
decreased vision,
fogginess in the eyes,
high pressure (intraocular),
nerve damage (eye)
long healing of wounds,
tearfulness,
allergic reaction (irritation, redness, itching, rash),
angioedema,
anaphylactic shock.

These side effects are due to the action of the steroid. As a result of their long-term use, a fungal infection may even develop.

Contraindications

As for pregnant women, they are not included in the risk zone. The exception is mothers who breastfeed their babies. But those who have the eye diseases described below should seriously think about it before starting treatment:

fungal diseases;
personal intolerance to components;
eye tuberculosis;
after removing a foreign body;
purulent infection of the mucous membrane;
corneal ulcer;
lichen (shingles);
special sensitivity to antibiotics.

The instructions do not say anything about whether it is permissible to use this remedy to treat children. If you use Maxitrol in parallel with other similar drugs, then maintain an interval of approximately 10-15 minutes.

Some guidelines

The shelf life of this product is 2 years, but this is provided that you did not open it and it was in a dry, cool and dark place. If you have already opened it, then the period is reduced to one month.

And one more reminder: before opening, the bottle must be shaken well, and after use, be sure to close. It must be in a vertical position.

With this, I would like to end our excursion into the world of the drug “Maxitrol”. We really hope that you are satisfied, our dear user. In any case, know that we tried very hard to make you feel comfortable with us.

One milliliter of eye drops contains 3500 units. neomycin sulfate and 6000 units. polymyxin (B) sulfate, as well as 1 mg dexamethasone and excipients: neutral additives, polysorbate 20, hydroxypropyl methylcellulose (0.5%), distilled water. Benzalkonium chloride 0.004 percent was used as a preservative.

Eye drops are available in 5 ml bottles with dropper Drop-Tayner. Each bottle is sealed in a cardboard box.

It has a local antibacterial and anti-inflammatory effect.

Maxitrol eye drops are a combination drug used in ophthalmology. Neomycin capable of disrupting protein synthesis (bactericidal effect, development of resistance is slow and to a small extent) in bacteria such as:

Staphylococcus aureus(Staphylococcus aureus);
bacteria-pathogens of diphtheria(Corynebacterium diphtheriae);
low pathogenic streptococcal bacteria (Streptococcus viridans);
coli(Escherichia coli);
Friedlander's bacillus (Klersiella pneumoniae);
common proteus (Proteus vulgaris);
gram-negative rod-shaped bacterium (Aerobacter aerogenes);
hemophilus influenzae (Haemophilus influenzae).

At the same time neomycin not active against pathogenic fungi, viruses and anaerobic flora.

The active substance of this drug is Polymyxin B sulfate acts by blocking the permeability of the cytoplasmic membrane of cells of a number of bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, coli And Friedlander sticks, and also Koch-Weeks bacilli, causing conjunctivitis.

Dexamethasone is glucocorticosteroid, which has anti-inflammatory, antiallergic, antiexudative and desensitizing effects. In combination with antibiotics significantly reduces the risk of developing infection.

Pharmacokinetics

Topical application is characterized by a low level of systemic absorption.

Maxitrol eye drops are usually used for various infections of the eyes and appendages:

at blepharitis;
conjunctivitis;
keratoconjunctivitis;
keratitis;
iridocyclitis;
and also as prevention V postoperative period at inflammation front part eyes.

The drug should be used with caution when glaucoma And cataract.

Local side effects usually appear as allergic reactions, accompanied itching, swelling of the eyelids And redness of the conjunctiva.

The steroid component causes increased intraocular pressure with subsequent development glaucoma, damage to the optic nerve and visual fields, posterior subcapsular cataracts, delayed wound healing.

In addition, the course of treatment - more than 10 days requires monitoring of intraocular pressure;

In addition, the following may occur:

secondary infection with glucocorticosteroids And antibiotics;
fungal infection corneas with long-term use steroids, up to education non-healing ulcers indicating fungal invasion.

Directions for use: topically, into the conjunctival sac. Before use, shake the bottle with drops and be sure to close it after.

The instructions for Maxitrol eye drops differ depending on the severity of the infectious process:

mild form - 1–2 drops. must be instilled every 4–6 hours;
severe infectious process - 1–2 drops. it is necessary to instill every hour; as the inflammation decreases, you can reduce the frequency of drug instillations.

At the moment, there are no cases of overdose with local use.

If it is necessary to use other local ophthalmic agents, the interval before using the next drug should be at least 10 minutes.

The drug is sold in pharmacies only with a prescription.

Keep out of the reach of children. Make sure that the temperature is between 8–30° Celsius and the bottle is in an upright position.

Two years. After opening the bottle - up to 4 weeks.

Analogs of eye drops that can reduce the risk of developing inflammatory processes:

Dexa-Gentamicin
Dex-Tobrin
Medetrom
Polydexa
Polydexa with Felinephrine

Reviews about eye drops are few, since the drug is sold in pharmacies only by prescription, but those who have used Maxitrol note that it helps, does not burn the eyes and does not cause other adverse or allergic reactions.

The price of eye drops in a 5 ml bottle is 350-440 rubles.

Maxitrol 0.1% eye drops 5ml dropper bottle Alkon-Kuvrer N.V.S.A.

MaxitrolAlcon-Couvreur, Belgium

MaxitrolAlcon-Couvreur (Belgium)

Maxitrol 5 ml eye drops.

Maxitrol 3.5 g eye ointment.

Clinical and pharmacological group

A drug with antibacterial and anti-inflammatory effects for topical use in ophthalmology

5 ml - polyethylene bottles with a Drop-Tayner dropper (1) - cardboard packs.

Pharmacological action

Neomycin has a bactericidal effect by disrupting the protein synthesis of the bacterial cell. Active regarding Staphylococcus aureus, Corynebacterium diphteriae, Streptococcus viridans, Escherichia coli, Klersiella pneumoniae, Proteus vulgaris, Aerobacter aerogenes, Haemophillus influenzae.

The mechanism of action of polymyxin B is mainly due to the blockade of the permeability of the cytoplasmic membrane of bacterial cells. Active regarding Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Klersiella pneumoniae, Koch-Weeks bacillus.

Dexamethasone

GCS. It has anti-inflammatory, antiallergic and desensitizing effects. Has an antiexudative effect. Dexamethasone effectively suppresses inflammatory processes.
The combination of GCS with antibiotics can reduce the risk of developing an infectious process.

Pharmacokinetics

Infections of the eyes and its appendages:

Blepharitis;

Conjunctivitis;

Keratoconjunctivitis;

Keratitis;

Iridocyclitis.

Contraindications

Individual hypersensitivity to the components of the drug;

Viral eye diseases (including keratitis caused by Herpes simplex, chicken pox);

Mycobacterial eye infection;

Tuberculous eye diseases;

Acute herpes zoster;

Fungal eye diseases;

Condition after removal of a corneal foreign body;

Purulent infection of the mucous membrane of the eye and eyelids caused by neomycin-resistant microorganisms, purulent corneal ulcer.

With caution prescribed for glaucoma and cataracts.

Dosage

Locally. At mild infectious process 1-2 drops into the conjunctival sac 4-6 times/day.

At acute severe infectious process 1-2 drops into the conjunctival sac every 60 minutes, decreasing the frequency of drug instillations as inflammation decreases.

Side effects

Local. An allergic reaction, accompanied by itching and swelling of the eyelids, hyperemia of the conjunctiva. Side effects caused by the steroid component: increased intraocular pressure with the possible subsequent development of glaucoma, damage to the optic nerve and visual fields (when using the drug for more than 10 days, monitoring of intraocular pressure is necessary); posterior subcapsular cataract, slowing of the wound healing process. Topical use of steroids for diseases that cause thinning of the cornea or sclera can lead to their perforation.

Secondary infection. The development of secondary infection is observed after the use of combination drugs containing corticosteroids in combination with antibiotics. With long-term use of steroids, fungal infections of the cornea may develop. The appearance of non-healing ulcers on the cornea after long-term treatment with steroid drugs may indicate the development of fungal invasion. Secondary bacterial infection can occur as a result of suppression of the patient’s protective reaction.

Drug interactions

Interaction with other drugs is currently not known.
When used with other local ophthalmic drugs, the interval between their use should be at least 10 minutes.

The safety and effectiveness of the drug for children have not been established.

The drug is available with a prescription.

Trade name: Maxitrol

International nonproprietary name/Group name:
Dexamethasone+Neomycin+Polymyxin B

Chemical name:
Dexamethasone: 9-fluoro-11β, 17, 21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
Neomycin sulfate: 2-deoxy 4-0-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-5-0-D-streptamine (neomycin B), sulfate
Polymyxin B sulfate: mixture of polypeptide sulfates

Composition of 1 ml of the drug
Active ingredients: dexamethasone 1.0 mg;
neomycin sulfate 3500 IU;
polymyxin B sulfate 6000 IU.

Excipients: benzalkonium chloride solution, equivalent to benzalkonium chloride; sodium chloride, polysorbate 20, hypromellose* (4000 mPa.s), concentrated hydrochloric acid and/or sodium hydroxide to adjust pH, purified water.
* Synonym: Hydroxypropyl methylcellulose

Description: opaque suspension from white to light yellow

Pharmacotherapeutic group
Glucocorticosteroid + antibiotics (aminoglycoside and cyclic polypeptide).

ATX code: S0lCA0l

Pharmacological action

Pharmacodynamics
Combined preparation for local use in ophthalmology.

Neomycin has a bactericidal effect by disrupting the protein synthesis of the bacterial cell. Active against Staphylococcus aureus, Corynebacterium diphteriae, Streptococcus viridans, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Aerobacter aerogenes and Haemophilus influenzae.

The mechanism of action of polymyxin B is mainly due to the blockade of the permeability of the cytoplasmic membrane of bacterial cells. Active against Pseudomonas Aeruginosa, Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Koch-Weeks bacillus.

Dexamethasone is a glucocorticosteroid. It has anti-inflammatory, antiallergic and desensitizing effects. Has an antiexudative effect. Dexamethasone effectively suppresses inflammatory processes. The combination of a glucocorticosteroid with antibiotics can reduce the risk of an infectious process.

Pharmacokinetics
When applied topically, systemic absorption is low.

Indications for use
Infections of the eye and its appendages:

blepharitis;
conjunctivitis;
keratoconjunctivitis;
blepharoconjunctivitis;
keratitis;
iridocyclitis;

Prevention of postoperative infectious complications.

Contraindications

individual hypersensitivity to the components of the drug;
viral eye diseases (including keratitis caused by Herpes simplex, chicken pox);
mycobacterial eye infection;
tuberculous eye diseases; acute herpes zoster; fungal eye diseases;
condition after removal of a corneal foreign body;
purulent infection of the mucous membrane of the eye and eyelids caused by neomycin-resistant microorganisms, purulent corneal ulcer

With caution
Prescribe with caution for glaucoma and cataracts.

Use during pregnancy and lactation
There is no sufficient experience with the use of the drug during pregnancy and breastfeeding. It can be used for the treatment of pregnant women as prescribed by the attending physician, if the expected therapeutic effect exceeds the risk of developing possible side effects. The use of the drug should be interrupted during breastfeeding.

Use in pediatrics
The safety and effectiveness of the drug in children have not been established.

Directions for use and doses
Locally. For mild infections, 1-2 drops into the conjunctival sac 4-6 times a day.

In case of acute severe infectious process, 1-2 drops into the conjunctival sac every 60 minutes, with a decrease in the frequency of drug instillations as inflammation decreases.

Side effects

Local. An allergic reaction, accompanied by itching and swelling of the eyelids, hyperemia of the conjunctiva.

Side effects caused by the steroid component: increased intraocular pressure with the possible subsequent development of glaucoma, damage to the optic nerve and visual fields (when using the drug for more than 10 days, monitoring of intraocular pressure is necessary); posterior subcapsular cataract, slowing of the wound healing process. Topical use of steroids for diseases that cause thinning of the cornea or sclera can lead to their perforation.

Secondary infection. The development of secondary infection is observed after the use of combination drugs containing glucocorticosteroids in combination with antibiotics. With long-term use of steroids, fungal infections of the cornea may develop. The appearance of non-healing ulcers on the cornea after long-term treatment with steroid drugs may indicate the development of fungal invasion. Secondary bacterial infection can occur as a result of suppression of the patient’s protective reaction.

Interaction with other drugs
Interaction with other drugs is currently not known. When used with other local ophthalmic drugs, the interval between their use should be at least 10 minutes.

Special instructions
The bottle must be closed after each use. Shake the bottle before use.

Release form
Eye drops. 5 ml in a Droptainer™ dropper bottle made of low-density polyethylene. 1 bottle with instructions for use in a cardboard box.

Storage conditions
List B. Store at temperatures from 8 to 30°C. Keep out of the reach of children.

Best before date
2 years. Use within 4 weeks after opening the bottle.
Do not use after the expiration date indicated on the package!

Vacation conditions
By doctor's prescription.

When it comes to antibiotics in the field of ophthalmology, first of all, we should mention Maxitrol drops. Thanks to their action, an important process of suppressing infection begins to occur in the body, which leads to recovery. This drug is a combination drug and is used not only in the treatment of diseases of a bacterial nature. It is also effective in treating inflammatory processes caused by viruses and allergies.

Like all similar drugs, Maskitrol is available in special small bottles, only 5 ml in volume. For convenience, the bottle is made in such a way that it is convenient to use at any time and anywhere, that is, together with a dropper. This is a suspension, the color of which can vary from white to yellowish.

These drops are designed to have an antibacterial effect and serve as an anti-inflammatory agent. The main tasks are performed due to active substances:

Neomycin.
Dexamethasone.
Polymyxin B sulfate.

Thanks to the latter substance, the penetration of a number of bacterial pathogens, such as Pseudomonas aeruginosa and Escherichia coli, Friedlander's bacillus, and bacilli that can provoke certain diseases, is blocked in the body.

Among the auxiliary components are:

non-alkonium chlorite preservative,
sodium chloride,
polysorbate 20,
hypromellosis,
distilled water.

First of all, the medicine is produced to get rid of infections of the eye organs and their appendages, such as:

Bacterial keratitis.
Allergic and non-purulent conjunctivitis.
Keratoconjunctivitis.
Iridocyclitis.
For burns, barley.
As a preventive measure after surgery.

The drug has quite a lot of contraindications, so you should study the instructions before you start using this product. The use of the drug with diseases such as:

Tuberculosis of the organs of vision.
Fungal and viral infections.
For purulent forms of infections, including suppuration of the cornea.
Glaucoma and cataracts.
If a foreign body has been removed.
In cases of infectious damage to the eardrums.
If a person has chickenpox.

There are no special instructions regarding pregnant women, so the decision to use Maxitrol remains with the doctor. If the need to take the medication outweighs the possible risks, patients should use it during pregnancy and lactation, but with extreme caution.

There are also no contraindications for children, nor any special effective or safe effects of the drug, therefore, if it is possible to replace it with another drug, this should be done.

Try to put the medicine in a place where children do not have access. And one more important point that should be taken into account before the instillation procedure is shaking the bottle.

In cases where there is an overdose, or the solution accidentally enters the body, gastric lavage should be done and the doctor should be notified.

Local side effects may occur, such as an allergic reaction in the form of itching or swelling. Intraocular pressure can increase under the influence of steroids. This, in turn, can trigger the development of glaucoma and also slow down the healing process. If any hint of side effects occurs, taking Maxitol should be stopped.

Be sure to check the effect of eye drops for a reaction.

Secondary infections also occur. This occurs after prolonged use. When the immune system is suppressed, fungal infections can occur.

It should be used for mild forms of disease by instilling one or two drops up to six times a day. If the process is acute and has certain complications, the frequency of taking the drug increases several times and can be renewed every hour.

Medicines for stye on the eye

What laser coagulation of the retina is is described here.

All about Cromoglin drops

Self-medication with this drug is prohibited. Only if the instructions are followed exactly can the medicine have the desired healing effect. It is released strictly with a prescription, and its use is carried out under the supervision of the attending physician, this is due to possible serious complications.

Also read about drops such as Pharmadex and Baraplan.