Bromhexine active ingredient instructions for use. General characteristics

Bromhexine is a mucolytic drug with a pronounced expectorant effect. Improves the function of the bronchial mucosa, thins sputum. Widely used to treat people different ages due to low toxicity. The effect of taking the drug begins to appear after 1-2 days. After 2-5 days, a pronounced therapeutic effect appears. Available freely, without a prescription.

Diseases for which bromhexine is used

• Cystic fibrosis.
• Chronic pneumonia.
• Chronic bronchitis accompanied by bronchial obstruction.
• Tracheobronchitis.
• Occupational diseases respiratory organs associated with prolonged dirty, dusty air, etc.
• Pulmonary tuberculosis.
• Bronchial asthma.
• Other diseases respiratory system, in which stimulation of sputum excretion is required.

The drug is also used during recovery after operations on the respiratory organs, and to improve bronchography (radiography with contrast agent). By removing sputum, bromhexine promotes the passage of the contrast agent.

Instructions for use of bromhexine

Orally, in the form of inhalations and parentally (bypassing gastrointestinal tract). The parental form is used only in severe cases. In addition, the drug is administered parentally for postoperative treatment bronchi. Removal of thick sputum ensures high-quality sanitation.

Varieties of Bromhexine

Tablets for adults and children (with a reduced amount of active substance), elixir, mixture, solution for inhalation and parenteral administration.

Bromhexine dosage

For adults

Orally: 8 mg distributed 3-4 times a day.

Inhalations: take 2 times a day, 8 mg at a time.

For children

Inside

Up to 2 years: 6 mg, distributed 3 times a day.

2-6 years: 12 mg, distributed 3 times a day.

60-10 years: 18-24 mg, distributed 3 times a day.

For children over 10 years of age, single and daily doses are the same as for adults.

Inhalations

Up to 6 years: 2 times a day, single dose no more than 2 mg.

6-10 years: 2 times a day, single dose 2 mg.

Over 10 years: 8 mg, distributed 2 times a day.

Side effects of bromhexine

• Dizziness.
• Headache.
• Rash, redness on the skin.
• Bronchospasms.
• Cough.
• Digestive disorders.
• Increased amount of liver enzymes in the blood.

Bromhexine contraindications

There are no absolute contraindications to this drug.

Relative contraindications:

• Hypersensitivity.
• Pregnancy in the first trimester.
• Peptic gastric ulcer.
• Stomach bleeding.

Bromhexine during pregnancy

It is not recommended to take the drug during the first trimester of pregnancy. During the rest of pregnancy, as well as during breastfeeding, it is advisable to take bromhexine with the permission of a doctor. Negative influence Bromhexine on the fetus has not been proven by laboratory studies.

Attention! The information is provided for informational purposes only. This instruction should not be used as a guide to self-medication. The need for prescription, methods and doses of the drug are determined exclusively by the attending physician.

General characteristics

international and chemical names : bromhexine; (N-(2-Amino-3,5-dibromophenylmethyl)-N-methylcyclohexylamine hydrochloride);

basic physical and chemical properties : pills pink color, flat-cylindrical with chamfer. Marbling and inclusions of red are allowed;

compound: 1 tablet contains bromhexine hydrochloride in terms of 100% substance 8 mg;

excipients: lactose monohydrate, refined sugar, potato or corn starch (in terms of starch with a moisture content of 10%), calcium stearate, ruberosum.

Release form.
Pills.

Pharmacotherapeutic group

Medicines used for coughs and colds. Mucolytic agents.

Pharmacological properties

Pharmacodynamics. Mucolytic (secretolytic) and expectorant.
The mechanism of action is due to the depolymerization of mucoproteins and mucopolysaccharides sputum (Sputum– pathologically altered tracheobronchial secretion released during expectoration. It has bactericidal properties; its removal helps cleanse the respiratory tract of microorganisms, dust particles, metabolic products and cellular detritus), which reduces its viscosity. Increases the serous component of bronchial secretions, activates atrial fibrillation epithelium (Epithelium- a layer of closely spaced cells covering the surface of the body (for example, skin), lining all cavities and performing mainly protective, excretory and absorption functions), increases the volume of sputum and improves its discharge. Stimulates education endogenous (Endogenous(from endo... and...gene) - internal origin\; in medicine - originating from reasons underlying internal environment body) surfactant is a surface-active substance of lipid-protein-mucopolysaccharide nature, which is synthesized in the cells of the alveoli and ensures the stability of the alveolar cells during respiration.
Bromhexine has a weak antitussive effect.
The effect of bromhexine usually appears 2 to 6 days after the start of administration.

Pharmacokinetics. Quickly (within 30 minutes) and almost completely (99%) absorbed from the gastrointestinal tract. Bioavailability (Bioavailability- an indicator of the degree and speed of entry into the blood medicinal substance from the total dose administered)– about 80% due to the “first pass” effect through the liver. Penetrates the blood-brain and placental barriers, cerebrospinal fluid. Linking with proteins (Squirrels- natural high molecular weight organic compounds. Squirrels play extremely important role: they are the basis of the life process, participate in the construction of cells and tissues, are biocatalysts (enzymes), hormones, respiratory pigments (hemoglobins), protective substances (immunoglobulins), etc.) plasma (Plasma- the liquid part of the blood that contains shaped elements(erythrocytes, leukocytes, platelets). Changes in the composition of blood plasma are used to diagnose various diseases(rheumatism, diabetes mellitus etc.). Prepared from blood plasma medicines) – 99%. In the liver it undergoes demethylation and oxidation. Some of the resulting metabolites are pharmacologically active. Half-life (Half-life(T1/2, synonymous with half-elimination period) - the period of time during which the concentration of a drug in the blood plasma decreases by 50% from the initial level. Information about this pharmacokinetic indicator is necessary to prevent the creation of a toxic or, conversely, ineffective level (concentration) of the drug in the blood when determining the intervals between administrations) is 12 – 15 hours (due to slow return diffusion (Diffusion- movement of particles of the medium, leading to the transfer of matter and equalization of concentrations or to the establishment of an equilibrium distribution of concentrations of particles of a given type in the medium) from fabrics). Excreted mainly by the kidneys (85–90% in the form of metabolites).
For severe liver failure is decreasing clearance (Clearance(purification, purification) - a pharmacokinetic parameter reflecting the rate of purification of the blood plasma from the drug and denoted by the symbol C1) bromhexine, with chronic (Chronic- a long, continuous, protracted process, occurring either constantly or with periodic improvements in the condition) renal failure– the excretion of its metabolites is impaired. With repeated use, bromhexine may accumulate.

Indications for use

Spicy and chronic diseases respiratory organs, accompanied by difficulty in sputum evacuation as a result of the formation of a viscous and difficult-to-discharge secretion: tracheitis, acute and chronic bronchitis (Chronic bronchitis– a chronic inflammatory disease characterized by diffuse irreversible damage to the bronchi, the main symptom of which is productive cough with separation of mucous sputum) of various origins, including those complicated by bronchiectasis, bronchial asthma, pneumonia, pneumoconiosis, pulmonary tuberculosis. Sanitation (Sanitation- targeted therapeutic and preventive measures to improve the health of the body (for example, sanitation of the oral cavity)) bronchial tree V preoperative period(prevention of accumulation of thick viscous sputum in the bronchi after operations). Acceleration of removal of X-ray contrast agent after bronchography.

Directions for use and doses

Prescribed orally, regardless of food intake.
Adults and children over 14 years of age are prescribed 8 mg - 16 mg (1 - 2 tablets) 3 - 4 times a day; the maximum daily dose is 64 mg (8 tablets).
Children aged 10 to 14 years are prescribed 8 mg (1 tablet) 3 to 4 times a day; the maximum daily dose is 32 mg (4 tablets).
Children aged 6 to 10 years are prescribed 8 mg (1 tablet) 3 times a day; the maximum daily dose is 24 mg (3 tablets).
Patients with renal failure daily dose reduce.
The duration of treatment is determined individually depending on the indications and dynamics of the disease; can range from 4 days to 4 weeks.

Side effect

Bromhexine is generally well tolerated; Some patients may experience the following side effects.

From the respiratory system: cough, bronchospasm.

From the outside digestive system : dyspepsia (Dyspepsia– a digestive disorder resulting from a lack of enzymes or as a result poor nutrition) , nausea, vomiting, exacerbation of gastric ulcer and duodenum (Duodenum- initial department small intestine(from the gastric outlet to the jejunum). Length duodenum human equal to the diameter of 12 fingers (hence the name)); extremely rarely – transient increase in liver transaminases.

From the central side nervous system: dizziness, headache.

Others: allergic reactions (skin rash, rhinitis (Rhinitis- inflammation of the nasal mucosa, runny nose) etc.), increased sweating, angioedema (Angioedema - (Quincke's edema), acute limited paroxysmal swelling of tissues. Quincke's edema is the body's reaction to an allergen. Externally, Quincke's edema manifests itself as sharply limited swelling of tissues (mainly lips, eyelids, cheeks), sometimes skin rashes at the site of swelling, usually without itching or pain) faces, extremely rarely - anaphylactic shock.

Contraindications

Increased individual sensitivity to bromhexine and other components of the drug, peptic ulcer stomach, pregnancy period (especially the first trimester), period lactation (Lactation- secretion of milk from the mammary gland), childhood up to 6 years old.

Overdose

Symptoms: vomiting, impaired consciousness, ataxia (Ataxia- impaired coordination of movements. Manifested by imbalance when standing ( static ataxia) and actual movement coordination disorder (dynamic ataxia)), diplopia (Diplopia– doubling of the object in question, occurs as a result of deviation of the visual axis of one of the eyes), tachypnea, metabolic acidosis (Acidosis- offset acid-base balance body in the direction of increasing acidity (decreasing pH)) mild degree.

Treatment: discontinuation of the drug, artificial vomiting, gastric lavage (in the first 1–2 hours after administration), symptomatic therapy.

Features of application

The drug is prescribed with caution for renal and/or liver failure, for diseases of the bronchi accompanied by excessive accumulation of secretions, for gastric bleeding in medical history (Anamnesis- a set of information about the development of the disease, living conditions, previous diseases etc., collected for the purpose of use for diagnosis, prognosis, treatment, prevention).
During treatment, it is necessary to drink plenty of fluids (juices, tea, water) to enhance the mucolytic effect of the drug.

Use during pregnancy and breastfeeding.

The drug is contraindicated during pregnancy (especially in the first trimester). If use is necessary during lactation, breastfeeding should be discontinued.

Effect on ability to drive vehicles and complex mechanisms.

Care should be taken when driving vehicles and working with potential dangerous species activities that require increased attention and the speed of psychomotor reactions, since the drug can cause dizziness.

Interaction with other drugs

Simultaneous use with antibiotics (Antibiotics- substances that have the ability to kill microbes (or prevent their growth). They are used as drugs that suppress bacteria, microscopic fungi, some viruses and protozoa; there are also antitumor antibiotics)(amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfa drugs (sulfa drugs- group of antimicrobials medicines, derivatives of sulfanilic acid. Mainly used in treatment infectious diseases) promotes their penetration into bronchial secretions in the first 4 - 5 days of antimicrobial therapy (Therapy- 1. The field of medicine that studies internal diseases, one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate a type of treatment ( oxygen therapy\; hemotherapy - treatment with blood products)). When taken simultaneously with drugs that suppress the cough center (including codeine), it may be difficult to discharge liquefied sputum (accumulation of bronchial secretions in respiratory tract). When taken simultaneously with drugs that irritate the mucous membrane of the digestive tract, their irritating effect. Incompatible with alkaline solutions.
Possible simultaneous administration with bronchodilators.

General Product Information

Conditions and shelf life.
Store in a dry place, protected from light, at a temperature from 8 °C to 25 °C. Keep out of the reach of children.
Shelf life – 3 years.

Vacation conditions.
Over the counter.

Package.
Tablets of 8 mg No. 10, No. 10x2, No. 105, No. 20 in blisters in a box; No. 10, No. 20 in blisters.

Manufacturer.LLC "Pharmaceutical company "Zdorovye".

Location. 61013, Ukraine, Kharkov, st. Shevchenko, 22.

Website. www.zt.com.ua

Preparations with similar active ingredients

• Bromhexine - "Darnitsa"

This material is presented in free form based on official instructions for medical use drug.

Mucolytic drug Bromhexine helps reduce the viscosity of sputum, which gives a pronounced expectorant effect and facilitates mucus production. Bromhexine low toxic. Does not have a significant effect on blood circulation.

Indications for use

Acute and chronic inflammatory diseases trachea, bronchi, lungs; bronchiectasis (lung disease with formation of lung tissue cavities filled with sputum), pneumoconiosis ( common name occupational disease respiratory organs); in pre- and postoperative period, the drug is used for bronchography.

Directions for use

Accept bromhexine orally (regardless of food intake) in the form of tablets. Doses for adults - 0.016 g (16 mg = 2 tablets of 0.008 mg) 3-4 times a day; for children from 3 to 4 years old - 0.002 g (2 mg), from 5 to 14 years old - 0.004 g (4 mg) 3 times a day; The drug is not prescribed to children under 3 years of age.
The effect of the drug usually begins to appear 24-48 hours after the start of treatment. The course of treatment is from 4 days to 4 weeks.
When used by inhalation, the solution should be diluted 1:1 with distilled water and heated to body temperature to prevent coughing. In patients with bronchial asthma or asmatic bronchitis, a bronchodilator (a drug that dilates the lumen of the bronchi) should be taken before inhalation. Inhalation is carried out twice a day for adults 4 ml, children over 10 years old - 2 ml, children aged 6 to 10 years - 1 ml, children aged 2 to 10 years - 10 drops and children under 2 years old - 1 ml. 5 drops per inhalation. Parenteral (bypassing digestive tract) administration of the drug is recommended for treatment in severe cases, as well as in the postoperative period to prevent the accumulation of thick sputum in the bronchi. Administer 1 ampoule subcutaneously, intramuscularly or intravenously 2-3 times a day slowly for 2-3 minutes. The drug is administered intravenously along with glucose or saline solution. The drug is incompatible with alkaline solutions.
If necessary, bromtexin is prescribed simultaneously with antibacterial, bronchodilator, cardiac and other drugs.

Side effects

Rarely, when long-term use- nausea, vomiting, dyspepsia (digestive disorders), exacerbation of peptic ulcer. Extremely rare - angioedema (allergic) Quincke's edema, increased levels of transaminases (enzymes) in the blood serum.

Contraindications

There are no absolute contraindications. Relative: increased sensitivity to the drug, peptic ulcer, recent stomach bleeding, first trimester of pregnancy.

Release form

Tablets of 0.008 g, 0.016 g. Dragees of 0.004 g, 0.008 g, 0.012 g. Syrup (1 ml - 0.0008 g). Medicine (1 ml -0.0008 g). Solution for oral (by mouth) use (1 ml - 0.002 g). Elixir (1 ml - 0.0008 g, or 0.00016 g) Solution for inhalation use(1 ml -0.0002 g). Solution for parenteral use (1 ml - 0.002 g).

Compound

Core:
Active ingredient: bromhexine hydrochloride - 8,000 mg.
Excipients: lactose monohydrate, corn starch, gelatin, colloidal silicon dioxide, magnesium stearate;

Shell: sucrose, calcium carbonate, magnesium carbonate, talc, macrogol 6000, povidone K 25, glucose syrup, carnauba wax, titanium dioxide (E 171), quinoline yellow (E 104).

Storage conditions

Regular.

Synonyms

Bromhexine chloride, Bisolvon, Mucovin, Solvin, Brexol, Brodisol, Bromobene, Bromxin, Bisolvon, Brombenzonium, Brokokin, Lizomucin, Mugocil, Fulpen A.

Basic parameters

Name:	BROMHEXINE
ATX code:	R05CB02 -

Bromhexine: instructions for use and reviews

Latin name: Bromhexine

ATX code: R05CB02

Active ingredient: Bromhexine

Manufacturer: JSC "Pharmasintez", JSC "Dalkhimfarm", LLC "Yodillia-Pharm", JSC "PFK Obnovlenye", LLC "Bioreactor", JSC "Valenta Pharmaceuticals", JSC "Pharmstandard-Leksredstva", JSC "HFK Akrikhin", JSC "Vifitech", JSC "Biosintez" (Russia)

Updating the description and photo: 03.11.2017

Bromhexine is a mucolytic agent with an expectorant effect.

Release form and composition

• Tablets 8 mg (in cell packs and jars of various packaging);
• Tablets for children 4 mg (in blisters of 10 pieces);
• Oral solution 4 mg/5 ml (in bottles of 100 ml);
• Syrup 4 mg/5 ml (in bottles of 60 and 100 ml).

The active ingredient of the drug is bromhexine hydrochloride.

Pharmacological properties

Pharmacodynamics

Bromhexine is a prodrug that is converted into ambroxol in the body. The drug enhances the activity of lysosomes of goblet cells, which are part of the epithelium of the respiratory tract. This leads to the release of lysosomal enzymes responsible for the hydrolysis of mucoproteins and mucopolysaccharides. Bromhexine hydrochloride activates the production of surfactant and neutral polysaccharides, and also normalizes mucociliary clearance. This compound provides dilution of bronchial secretions increased viscosity and stickiness and its removal from the bronchi. Bromhexine is characterized by an antitussive effect.

Pharmacokinetics

Bromhexine penetrates the placental and blood-brain barriers. It binds to plasma proteins by 99%. There is also a “first pass” effect through the liver, where biotransformation occurs active ingredient drug with the formation of an active metabolite – ambroxol. Therapeutic effect becomes noticeable within 20-30 minutes after ingestion. The half-life is 6.5 hours, increasing in chronic renal failure. Bromhexine is excreted through the kidneys in the form of metabolites by approximately 85-90% and tends to accumulate in the body.

Indications for use

The use of Bromhexine is advisable in the treatment of respiratory tract diseases, the course of which is associated with the formation of a difficult-to-discharge viscous secretion:

• Chronic bronchitis with a broncho-obstructive component;
• Tracheobronchitis;
• Bronchial asthma;
• Chronic pneumonia;
• Cystic fibrosis.

Contraindications

A contraindication to the use of the drug is the patient's hypersensitivity to bromhexine.

Instructions for use of Bromhexine: method and dosage

Bromhexine solution, tablets and syrup are taken orally.

The dosage is determined based on the patient’s age:

• Children under 2 years of age are recommended to take 2 mg 3 times a day;
• Children from 2 to 6 years old – 4 mg 3 times a day;
• Children from 6 to 10 years old – 6-8 mg 3 times a day;
• Children over 10 years old and adults - 8 mg 3 times a day;
• If necessary, the dose can be increased: for adults – up to 16 mg 4 times a day, for children – up to 16 mg 2 times a day.

Use of the drug in the form of inhalations:

• Children under 6 years old - up to 2 mg 2 times a day;
• Children from 6 to 10 years old - 2 mg 2 times a day;
• Children over 10 years old - 4 mg 2 times a day;
• Adults - 8 mg 2 times a day.

The therapeutic effect usually appears on days 4-6 of use. The duration of treatment ranges from 4 to 28 days.

Parenteral administration is used in severe cases and in the postoperative period, in order to prevent the accumulation of thick sputum in the bronchi. The drug is administered (intravenously or intramuscularly) 2-3 times a day, 2 mg slowly over 3 minutes.

Side effects

• From the central nervous system: dizziness and headaches;
• From the respiratory system: bronchospasm, cough;
• From the digestive system: transient increase in the activity of liver transaminases in the blood serum, dyspeptic manifestations;
• Dermatological reactions: skin rash, excessive sweating.

Overdose

When taken too high doses Bromhexine may cause symptoms such as diarrhea, dyspepsia, nausea, and vomiting. In this case, symptomatic treatment is recommended.

Special instructions

When treating patients suffering peptic ulcer stomach, as well as persons with a history of gastric bleeding, the use of the drug should be carried out under the supervision of a physician.

For patients diagnosed with bronchial asthma, Bromhexine is prescribed with caution.

Bromhexine can be used in the composition combination drugs plant origin containing essential oils(including menthol, eucalyptus oil, peppermint, anise).

Use during pregnancy and lactation

According to the instructions, Bromhexine in any dosage form contraindicated in the first trimester of pregnancy. In the second and third trimesters, the drug can be prescribed after a thorough study of the balance between the benefits of therapy for the mother and the potential risks for the fetus. During the course of treatment with Bromhexine, breastfeeding must be stopped.

Drug interactions

When Bromhexine is combined with antitussive drugs, difficulty in sputum discharge may occur due to a weakening of the cough reflex. The drug is pharmaceutically incompatible with alkaline solutions (pH more than 6.3).

Analogues

Analogues of Bromhexine are:

• for tablets: Solvin, Bromhexine MS, Bromhexine Obolenskoye, Bromhexine-Egis, Bromhexine-UBF;
• for solution: Bromhexine-Egis, Bromhexine Nycomed, Bromhexine 4 Berlin-Chemie;
• for syrup: Bronchostop, Bromhexine-Acree.

Terms and conditions of storage

The shelf life of tablets and syrup is 5 years, solution – 3 years. Store in a dry place, protected from light and out of reach of children. Store syrup and tablets at a temperature no higher than 25 °C, solution – no higher than 30 °C.

One of the most known drugs, which are used in the fight against debilitating cough, is Bromhexine, proven over the years. Analogues of this drug will be studied in our article, since this information is important for people who do not have the opportunity to purchase Bromhexine, or who experience such rare occurrence, How individual intolerance drug.

The right alternative to a drug can be selected only by carefully studying its composition and principle of action. Bromhexine was no exception. Instructions, price, reviews, analogue (price will also be indicated) - all this information is presented in our article below.

Main active ingredient and principle of action of the drug

“Bromhexine” (analogs of which we will discuss in detail below) is positioned as a mucolytic drug that activates sputum production and thereby has an expectorant and weak antitussive effect. The main active ingredient in the drug is bromhexine hydrochloride. The prototype for its synthetic creation was a plant called Adhatoda vasica. Scientists noticed that the extract of this plant promotes easier discharge of sputum, and they created its synthetic analogue, which served as the basis for the creation of a drug such as Bromhexine (we will definitely study the price, reviews, analogues further).

Its principle of action is that bromhexine hydrochloride is able to depolarize acidic saccharides of bronchial secretions. Due to this, the viscosity of sputum is reduced. The activity of the ciliated epithelium increases significantly, which makes it easier to cough up sputum.

Indications for use

"Bromhexine" (instructions for use, price, analogues of which are discussed in this article) is considered simple, but quite an effective drug. Indications for its use are various diseases of the respiratory tract, accompanied by the formation of thick, viscous sputum that is difficult to separate:

• bronchial asthma;
• tracheobronchitis;
• acute bronchitis;
• alveolitis;
• chronic bronchitis (obstructive);
• chronic pneumonia;
• cystic fibrosis.

Types of "Bromhexine" and the main manufacturer of the drug

Most of the Bromhexine that is available to our customers is produced by a German pharmaceutical company called Berlin-Chemie. This manufacturer produces the drug in tablet form.

For use in adult patients, there are yellow or pink tablets containing 8 mg of bromhexine hydrochloride. They are produced in packs of 20 pieces. For children, the manufacturer produces tablets with a lower dosage of the active ingredient - 4 ml. They are available in packs of 10 pieces, as well as in dark glass bottles containing 50 tablets.

“Bromhexine” Berlin-Chemie (analogues of which are quite easy to select after studying the basic principle of the drug’s action) is also available in the form of a green dragee containing 4 mg of the active substance (50 pieces in a package). In addition, the drug is produced in the form of an elixir, 5 ml of which contains 4 mg of bromhexine hydrochloride.

"Bromhexine Berlin-Chemie", analogues of which can be easily found among the products of other manufacturers, is also produced by such domestic pharmacological manufacturers as "Akrikhin", "Biosintez", "Pharmstandard".

Pharmacological factories such as JSC Greenvex (Latvia), Darnitsa (Ukraine), and FC Zdorovye (Ukraine) also produce it. In addition to the same 8 mg and 4 mg tablets, these manufacturers also offer “Bromhexine” in the form of syrup, which can be produced in various packaging: 60 ml, 80 ml, 100 ml and 120 ml.

"Bromhexine": price

Analogues of this drug will be presented further; as for the cost of Bromhexine itself, it differs depending on its release form and dosage. Also, the price may vary slightly depending on the manufacturer and the markup applied by pharmacies. The average cost of the drug is as follows:

• 8 mg tablets (20 pcs per package) - from 20 rub. up to 60 rub.;
• 4 mg tablets (50 pcs.) - about 60 rubles;
• 8 mg tablets (25 pcs.) - from 90 rubles. up to 135 rubles;
• syrup (100 ml) - from 75 rub. up to 150 rub.

Customer Reviews

Bromhexine (analogs of which are more expensive than the drug itself) is relatively affordable for most of the population. Compared to other similar medications, its cost and availability allows you to purchase the drug immediately after a doctor’s prescription. In many ways, it is the price of the described medication that determines a large number positive feedback, which buyers leave about him.

People write that the first effect of taking the drug is noticeable within 2-3 days. It really relieves dry, debilitating and nonproductive cough, dilutes sputum and facilitates its easier discharge.

"Bromhexine" is a syrup, analogues of which pharmaceutical companies also available in sufficient quantity, has another advantage. It comes in a pleasant apricot flavor, making it easy for children to take. So sweet and delicious medicine young patients take it more willingly than regular pills.

"Bromhexine": analogs (synonyms) of the drug containing bromhexine hydrochloride

Having seen such drugs in the pharmacy as, for example, “Bromhexin-Akrikhin”, “Bromhexin 8”, “Bromhexin 8 Berlin-Chemie”, etc., you should not be mistaken and think that these are all analogues. You need to understand that this is all the same drug, which, depending on the dosage, contains in one tablet 8 mg or 4 mg of the same active substance - bromhexine hydrochloride. The only way these drugs differ from each other is the manufacturer and cost.

This list of synonyms-analogs, which contain the same active substance as Bromhexine, can be continued with the following drugs:

• "Mugotsil."
• "Bromobene."
• "Bisolvon".
• "Mukovin."
• "Fulpen A".
• "Brokokin."
• "Solvin".
• "Lysomucin".
• "Bromhexine chloride."

These medications may vary excipients, included in their composition, but the main thing is active substance they have one. Accordingly, they have the same principle of action, indications and contraindications for use as Bromhexine.

Complete analogues of "Bromhexine"

Thanks to the developed pharmaceutical production and a huge number of the medicines it produces, almost any drug today can be replaced with another, similar in action. Bromhexine was no exception. Analogs, instructions for use and composition of which we will further consider, are provided in large quantities, but the most popular and in demand among them are:

• "ACC."
• "Doctor Mom"
• "Lazolvan."

The active substance in these drugs, indications for use and average cost will be discussed in detail below.

"ACC" is one of the most famous antitussive drugs

This drug is really familiar to those who have chronic respiratory diseases. It has 3 release forms, including - effervescent tablets, powder (for making your own hot drink) and syrup.

Main active component is the substance acetylcysteine. Once in the body, this synthetic component breaks the bisulfide bonds of mucopolysaccharides in sputum.

Thanks to this, "ACC", like all other analogue drugs of "Bromhexine", thins thick sputum and promotes its easier and more active discharge. This drug is successfully prescribed for such problems and diseases as:

• sinusitis;
• bronchiectasis;
• tracheitis;
• obstructive, chronic, acute bronchitis;
• cystic fibrosis;
• laryngitis;
• exudative otitis media;
• bronchiolitis.

The cost of the drug depends on the content of acetylcysteine ​​in 1 tablet or 1 package:

• ACC 100 tablets (1 tablet contains 100 mg of acetylcysteine) cost about 250-300 rubles. (20 pcs per pack);
• tablets "ACC 200" - 250 rubles;
• tablets "ACC 600" - 280 rubles;
• a package of packets of ACC100 powder (1 packet contains 100 mg of acetylcysteine) costs about 130-150 rubles. (20 packages);
• ACC 200 powder (20 packets) - about 140-170 rubles;
• ACC 600 powder (6 packets) - 140 rubles;
• syrup 100 ml - 220 rub. and 200 ml - about 300 rubles;

It is quite difficult to come across negative reviews about “ACC”, since it is really effective in the fight against cough. Some people call its only disadvantage its high price, compared to other analogue drugs.

"Doctor Mom" ​​is one of the best alternatives to Bromhexine syrup

This product is a herbal preparation, because it contains an extract of more than 10 medicinal herbs, including turmeric, licorice root, cubeba pepper and aloe. The drug is available in the form of lozenges and warming ointments, but the most popular is the “Doctor Mom” syrup.

The principle of this herbal preparation is that, thanks to its mucoltic, bronchodilator and expectorant action, it, like Bromhexine, dilutes sputum, facilitates its discharge when coughing, thereby cleanses the bronchi and relieves inflammation.

Thanks to his medicinal effect this drug is effective in the treatment of various acute and chronic diseases respiratory tract:

• bronchitis;
• tracheitis;
• laryngitis;
• pharyngitis.

The manufacturer's recommended price for 1 bottle of syrup (100 ml) is 165 rubles, but it may vary slightly depending on the markup of pharmacies. Customer reviews about this drug are mostly positive. Patients note that Doctor Mom really thins the cough and facilitates sputum discharge. The first results are noticeable after just a few doses. In addition, the syrup has residual good taste and is suitable for both adults and children (from three years old).

“Lazolvan” is a real salvation from a debilitating cough

This drug is also quite popular and is often prescribed by doctors. It is available in the form of tablets, syrup, solution in ampoules for intravenous administration and in vials for oral administration.

The main component in its composition is ambroxol hydrochloride, which in the respiratory tract activates the production of mucus and promotes its release from the bronchi. Thus, the cough becomes wet and productive.

This drug has enough wide range indications for use, including:

• obstructive pulmonary disease;
• BA, accompanied by severe sputum discharge;
• pneumonia;
• chronic and acute bronchitis;
• bronchiectasis.

The average cost of tablets (20 pcs.) is 165 rubles, lozenges for resorption (20 pcs.) cost about 200 rubles, syrup (100 ml) - 205 - 290 rubles, and a solution for inhalation and internal use(100 ml) will cost about 350 rubles.

How to make the right choice

We can conclude that “Bromhexine”, instructions for use, analogues of which are discussed above, is quite effective drug. Moreover, its price is affordable for most of the population. In pharmacies you can find drugs that have almost the same properties as Bromhexine. medicinal effect, while their price exceeds the cost of Bromhexine.

Despite the fact that all analogue drugs have a good reputation, and customer reviews about them are mostly positive, we recommend purchasing any drug only on the basis of a doctor’s prescription. After all, despite the same principle of operation, we should not forget that active substances All of these drugs are different.