Acidine pepsin is a combination drug. "Acidin pepsin" - a remedy for better digestion

Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.

Acidin-Pepsin: instructions for use

Compound

each tablet contains active substances: betaine hydrochloride (acidine) in terms of 100% substance - 200 mg; pork pepsin (in terms of 100% pepsin) - 0.5 mg; excipients: povidone K-25, colloidal silicon dioxide anhydrous, calcium stearate, sorbitol.

Description

Tablets are white or white with a slightly yellowish tint, with a specific odor, sour taste, flat-cylindrical with notch and chamfer. Marbling on the surface of the tablets is allowed.

Pharmacological action

Digestive (proteolytic) enzyme agent. Pepsin is one of the main proteolytic enzymes digestive tract. It is produced in the cells of the gastric mucosa in an inactive form (as the proenzyme pepsinogen), which is converted into an active enzyme in the gastric contents. Pepsin acts on initial stage digestion of proteins in the digestive tract. In the acidic environment of gastric contents, it hydrolyzes proteins into peptides. Among the hydrolysis products there are also amino acids. Pepsin exhibits optimal activity at pH 1.4-2.5. At pH 5.0 it causes milk to curdle. If the pH increases, pepsin activity decreases, and when the pH is more than 6.0, it stops. Hydrochloric acid increases acidity gastric juice, creates the optimal pH for pepsin activity. Pepsin and hydrochloric acid (formed as a result of the hydrolysis of betaine hydrochloride) increase the acidity of gastric juice and have proteolytic properties, which promotes digestion in the stomach.

Indications for use

Hypocidal and anacid gastritis, achylia, dyspepsia.

Contraindications

Hypersensitivity, hyperacidity of gastric juice (including gastric ulcer and duodenum, erosive gastroduodenitis).

Pregnancy and lactation

Data on the possibility of using the drug during pregnancy and lactation have not yet been received, therefore the use of acidin-pepsin during pregnancy is possible only if potential benefit for the mother exceeds the risk for the fetus, and if it is necessary to prescribe the drug during lactation, it is recommended to resolve the issue of stopping breastfeeding.

Directions for use and doses

Orally, during or after meals, after dissolving in 50-100 ml of water. Adults - 2 tablets 3-4 times a day, children - 1/4 - 1/2 tablets 3-4 times a day.

Side effect

Allergic reactions, heartburn, gastralgia.

Overdose

To date, the phenomena of drug overdose have not been described. Rarely, when used in large doses, possible: nausea, heartburn, gastralgia, vomiting, diarrhea, allergic reactions.

Interaction with other drugs

The effect of acidin-pepsin decreases with simultaneous administration antacids (Maalox, phosphalugel, rutacid, gelusillac, Rennie, sodium bicarbonate, etc.), tannin. Pepsin is destroyed by alcohol.

The medication is prescribed for oral use at the time of eating or immediately after it. Acidin-pepsin tablet or powder is diluted in water. The ointment form is first applied to gauze bandage and then onto the body. This procedure is performed strictly as directed by the doctor for no more than one day. Reception alcoholic drinks leads to the destruction of endopeptidase. Therefore, drinking alcohol during treatment is strictly prohibited. Orally, globular protein is administered in a dosage of 0.2 to 0.5 g during or after meals. The frequency of use during the day should not exceed 2-3 doses. The duration of the course of therapy is determined by the attending physician. The standard regimen provides treatment for from 15 days to one month. For the treatment of gastrointestinal pathology in childhood, the dosage is much lower and ranges from 0.05 to 0.3 g with two or three doses per day. The concentration of hydrochloric acid should not exceed 2%. The rate of administered hydrolase is adjusted taking into account the age of the minor patient. The medication in tablet form is taken one or two units for two to four weeks. For adult patients, the maximum single dose is 0.5 g, taken three times a day. For children, the instructions for use reduce the daily amount of the chemical product by half, or even up to a quarter of the tablet. Today endopeptidase is used in food industry to catalyze the curdling reaction of milk or in rennet starter for the preparation of hard cheeses. Another important enzyme in the sourdough process is chymosin. During the coagulation reaction, the main milk protein, casein, coagulates, forming a milky viscous substance in the form of a gel. And the structure of casein is such that the peptide bond is responsible for its fermentation. The breakdown of protein causes milk to clot. Despite great value the use of globular proteins in cheese making, their role in medical practice even more important. Sometimes patients do not even realize that they are using medications made on the basis of specific hydrolases. But this does not make the drug less effective. Sometimes you can find complaints from patients about the occurrence of pain in the stomach during a course of therapy. Doctors believe that such collateral symptoms are considered the body's reaction to long term deficiency an acidic compound that irritates the pituitary surface of the gastrointestinal tract. Some people suffering from enzyme deficiency and poor production hydrochloric acid, take the drug Acidin-pepsin without a doctor’s prescription. But without finding out the whole picture of the state of the gastrointestinal tract correct treatment impossible. A doctor can make a diagnosis only after a detailed examination of the patient’s health. Information about dose adjustments in patients suffering from renal or hepatic dysfunction, as well as for older people age group, are not presented.

Pepsin breaks down almost all animal proteins and plant origin. Pancreatic enzymes, trypsin and chymotrypsin, also participate in the breakdown of proteins. But pepsin, unlike these enzymes, does not have strict specificity for the proteins being broken down.

The action of pepsin occurs only in an acidic environment. Optimal pepsin activity is observed when the concentration of free hydrochloric acid is not less than 0.15-0.2%, maximum activity pepsin – at pH = 1.5-2.0.

In some diseases it is noted complete absence(achilia) or decreased production of hydrochloric acid in the stomach (hypoacid state). The consequence of this pathology is a lack of digestive activity of pepsin and, consequently, gastric juice. In such cases it is used replacement therapy– taking pepsin or drugs containing pepsin.

The pharmaceutical drug pepsin is prepared from the stomachs of pigs, large cattle, hens and chicks. The digestive activity of chicken pepsin is observed in a larger pH range (2-4) than that of pork pepsin. This makes it possible not to prescribe additional hydrochloric acid for administration.

Used for oral administration and enzymatic preparation Acidin-pepsin. Betaine hydrochloride, which is part of it, is converted in the stomach into free hydrochloric acid, which activates pepsin.

Release forms

• Pepsin is available in powder form, which should be stored in closed jars, in a dark place, at a temperature of +2 to +15 o C. The powder is yellowish or white, sweet and sour taste, soluble in water and in ethyl alcohol(20%). In the pharmacy, a solution of pepsin and hydrochloric acid in water is prepared from the powder.
• Pepsin K (chicken pepsin) – 0.1 g tablets; the tablet contains 0.04 g of pepsin; per package 25 or 50 tablets.
• Acidin-pepsin ( combination drug, consisting of 1 part pepsin and 4 parts betaine hydrochloride) is available in the form of tablets of 0.25 or 0.5 g, 50 pieces per package.
• Ointment with pepsin is not produced by pharmaceutical factories, but is prepared in pharmacies according to a prescription (5-10% ointment: pepsin with hydrochloric acid on a vaseline or lanolin basis).

Instructions for use of pepsin and Acidin-pepsin

Indications for use

Taking pepsin orally is indicated for diseases gastrointestinal tract with reduced secretory function of the stomach:

• hypoacid gastritis (reduced production of hydrochloric acid in the stomach), anacid gastritis (inflammation of the stomach in the absence of hydrochloric acid production);
• achylia (lack of hydrochloric acid production and digestive enzymes in the stomach) with atrophic gastritis, insufficiency of proteins and vitamins in the diet, malignant form anemia, liver cirrhosis, endocrine disorders(increased levels of thyroid hormones), etc.;
• condition after removal of part of the stomach;
• dyspepsia (indigestion).

Pepsin can be used externally to treat keloid scars, necrotic long-term non-healing ulcers in the form of an ointment.

Contraindications

Pepsin and Acidin-pepsin are not prescribed for an allergic reaction to the drug, for gastric ulcers, erosive gastritis(superficial, shallow ulcers on the gastric mucosa), with increased acid and enzymatic function of the stomach.

Side effects

When using Pepsin and Acidin-pepsin in in rare cases may be noted:

• allergic reaction;
• bowel dysfunction (diarrhea or constipation);

Treatment with pepsin and Acidin-pepsin

How to take?
Pepsin and Acidin-pepsin are taken orally during or after meals. Before taking, the Acidin-pepsin tablet should be pre-dissolved in 100 ml of water, and pepsin in powder form should be dissolved in water or in a 1-3% solution of hydrochloric acid.

Ointment dressings are applied (strictly as prescribed by the doctor) for a day.

Pepsin is destroyed by alcohol, so you should avoid drinking alcohol while taking this drug.

Dosage
Pepsin is prescribed orally for adults at a dose of 0.2-0.5 g during or after meals in powder form or in a 1-3% solution of diluted hydrochloric (hydrochloric) acid 2-3 times a day. The duration of the course is determined by the doctor. Usually prescribed for 2-4 weeks.

For children, pepsin is prescribed only by a doctor in a dose of 0.05 to 0.3 g 2-3 times a day or in a 1-2% solution of hydrochloric acid, depending on age.

Pepsin K is taken 1-2 (maximum 3) tablets after meals for a course of 2 to 4 weeks.

Acidin-pepsin for adults is prescribed 0.5 g 3 times a day. Children are prescribed half or a quarter of a tablet (0.25 each) depending on age.

Compatibility with other drugs

The effectiveness of pepsin-containing drugs decreases when simultaneous use acid-reacting drugs, tannin, antacids ( baking soda, burnt

Digestive problems are quite common in modern medical practice. The drug "Acidin-pepsin" is considered one of the few drugs that can quickly cope with similar violations. And today many people are interested in information about the composition and properties of this medicine.

The drug "Acidin-pepsin": composition and release form

This combination remedy with two main ones at once active ingredients: acidin (or betaine hydrochloride) and pepsin. Each tablet contains 50 mg of the proteolytic enzyme pepsin and 200 mg of acidin. Available this drug in the form of tablets, which can be placed either in blisters or dark glass jars. Today, pharmacies sell packages of 20, 30, 40, 50 and even 100 tablets, so each patient can choose the best option for himself.

Main properties of the medicine

Pepsin is an enzyme that is responsible for the initial digestion of protein substances in the stomach. It is secreted by specific cells of the gastric mucosa and is activated under the influence of hydrochloric acid. So when insufficient quantities The drug's own enzymes promote rapid fragmentation of protein substances. The second active substance of the drug, acidin, increases the acidity of gastric juice, thereby creating an optimal acidity of the environment for the activity of pepsin and other digestive enzymes.

When should you take the medicine?

The drug "Acidin-pepsin" is widely used to treat a host of diseases and disorders of the digestive tract. Naturally, the medicine is indispensable for people suffering from low acidity and lack of digestive enzymes. In particular, the indication for use is hypocidal or anacid gastritis, as well as any other inflammatory disease stomach, which is accompanied by a decrease or complete absence of hydrochloric acid in the gastric juice. In addition, the drug is indispensable for achylia, a disease characterized by the cessation of the synthesis of enzymes and acid in the stomach. In addition, the medicine is widely used to treat and eliminate the symptoms of dyspepsia - a digestive disorder accompanied by impaired digestion of protein compounds. By the way, dyspepsia can be a sign of a serious illness, or it can arise as a result poor nutrition or organic lesions digestive system.

The drug "Acidin-pepsin": instructions for use

Of course, you should talk to your doctor before starting to take the drug. After all, it is almost impossible to independently determine the need for medication, select the appropriate dose and dosage schedule. As for recommendations, adults in most cases take two tablets three or four times a day. By the way, it is best to dissolve the tablet in water (no more than half a glass). You need to drink the solution during meals or immediately after meals. The medicine "Acidin-pepsin" is often prescribed to children, but here it is extremely important that the doctor chooses the dose, since the daily amount of the drug depends on the age of the child, his body weight, the condition of the body and many other factors. Most often, the daily dose is 1-2 tablets, divided into 3-4 doses.

Side effects and contraindications

Like all other medications, Acidin-pepsin has some contraindications. To begin with, it is worth noting that tablets are prohibited for people with hypersensitivity to any of the constituent components of this medication. In such cases, an allergic reaction cannot be excluded, which is accompanied by swelling, redness and rash on the skin, itching, burning, etc. In addition, those diseases of the gastrointestinal tract that are accompanied by hyperacidity of gastric juice are considered contraindications. For example, similar phenomenon observed when ulcerative lesions stomach and intestines, as well as some erosive diseases, including gastroduodenitis. TO relative contraindications may include pregnancy, lactation, and childhood, but only because studies have not been conducted among this group of patients. However, if necessary, your doctor may prescribe this medicine. As for side effects, then they are rarely recorded; Most often, the drug is well tolerated by patients. Only in some patients does therapy cause digestive disorders, including nausea, constipation and severe heartburn. When similar symptoms You should stop taking the medication for a while and consult a specialist as soon as possible.

The action of the drug Acidin-pepsin is aimed at reducing the food load on the pancreas and improving digestion processes. The medication belongs to the category of enzyme agents. Before starting treatment with this drug, you must study the list of contraindications noted by the manufacturer in special paragraphs of the instructions.

Taking Acidin-pepsin, if present, will reduce therapeutic effect medicine and will increase the risk of developing side symptoms. The medication combines well with drugs from other groups. This feature allows it to be used as an adjunct to therapy. chronic diseases And inflammatory processes in the digestive tract.

1. Instructions for use

The instructions contain information about indications, contraindications, required dosage, as well as the method of administration. In addition, it contains information about side effects, possible overdose when taking the medicine in dosages exceeding the maximum permissible norm, as well as the release form. For a complete overview of the medicine, the article also contains information about the price and analogues.

Pharmacological action

Acidin-pepsin contains components that affect the acidity of gastric juice, functional state stomach and the digestive system as a whole. The use of the medication allows you to restore some processes in the gastrointestinal tract and eliminate a number of dyspeptic disorders.

The drug can be used in the treatment of inflammatory processes associated with the digestive system (as part of complex therapy).

Pharmacological properties:

Indications

The medicine Acidina-pepsin can be prescribed to patients in such cases as:

• Digestive system disorder of any origin;
• Inflammatory diseases of the digestive canal, which are accompanied by low level acidity in the stomach, for example, gastritis with low acidity;
• Disruption of the process of formation of hydrochloric acid.

Method of administration

The drug must be taken orally, during or immediately after meals. Adults can be prescribed the medicine in a dosage of 2 tablets (they must be dissolved in 1/4 or 1/2 cup of liquid). The number of doses per day is 3-4 times.

In pediatrics, a single dosage should not exceed 1/4 tablet. The frequency of administration of the drug in children is the same as in adults.

The duration of therapy can only be determined by a doctor.

Release form

The medicine is available in the form of tablets that have a white or yellowish tint. In addition, the pills also have a specific sour taste.

The product contains acidin and pepsin. Except active substance The composition also contains calcium stearate, povidone, colloidal silicon dioxide and sorbitol.

Combination of drugs

At joint reception the drug Acidin-pepsin with antacids may reduce the therapeutic effect of the drugs.

This remedy should never be combined with hydrochloric acid preparations. pure form, because in this case, the risk of developing an ulcer on the gastric or duodenal mucosa sharply increases.

In addition, it is also not allowed to take the product with its analogues, for example, Betacid, Acipepsol or Pepsamin, because in this case, the risk of developing serious side effects.

2. Side effects

As a rule, tablets of the drug Acidin-pepsin are quite well tolerated by patients. However, in isolated cases when exceeding the maximum permissible norm The patient may begin to develop side effects such as:

• Development of constipation;
• Hives, rash, and itching.

If side effects occur, you should stop taking the medicine and consult a doctor immediately. Practice shows that after stopping the medication, all manifestations go away on their own, however, there are cases when treatment is still required.

To date, no cases of overdose have been recorded, however, doctors still do not exclude the possibility of its occurrence. It can be expressed in increased side effects or headaches.

Overdose

Exceeding the dosage of Acidin-pepsin can cause heartburn or chronic constipation. If an overdose was allowed in the presence of contraindications, then its consequence may be an allergic reaction. Negative symptoms imply not only the abolition of the medication, but also symptomatic therapy. Chronic constipation eliminated with laxatives. The reason for stopping the course of therapy with Acidin-pepsin or adjusting the dosage is attacks of nausea or vomiting after taking it.

Contraindications

Based on the instructions, the medicine can under no circumstances be prescribed if the patient has such conditions and diseases as:

• Gastritis with high acidity in the stomach;
• Malignant tumor of the stomach;
• Allergy to certain components of the drug;
• Bleeding from the stomach, as well as gastroduodenitis.

Pregnancy

During pregnancy from taking this tool It's better to refuse. If it is impossible to refuse the drug, then its use is allowed, however, the girl must be in a hospital or under the supervision of a doctor.

During the same period breastfeeding V extreme cases You are allowed to take this medicine. While taking the drug, you need to carefully monitor the baby's reaction. If the child begins to be capricious, sleep and eat poorly, then the medication should be stopped.

All gastroenterology clinics and medical centers in your city. Tests and ultrasound. Consultation with a gastroenterologist. Diseases of the digestive system. Find out more:
- In Kyiv (Hertz, Ilaya, Euromed)
- In St. Petersburg (SM-Clinic, Longevity, Allergomed, Doctor +, BaltZdrav, Professor)
- In Moscow (SM-Clinic, Medlux, Onmed)
- In Kharkov (CMEI, Olympic, Victoria, Fortis, Ecomed)
- In Minsk (Belgirudo, Art-Med-Company, Sinlab, Mikosha, GrandMedica, MedClinic)
- in Odessa (Medea, On Clinic, Into Sano, Venus)
- In Razyan (Trust +, Polyclinic-Sandbox, Evrikas +)
- in Nizhny Novgorod (Only Clinic, Alpha Center, EuroClinic, SOLO, Altea)
- gastroenterological clinics of Tyumen (Doctor A+, Clinic "Vera", Avicenna, Medis, Sibirina, Your Doctor)

3. Special instructions

Impact on the ability to drive vehicles and operate machinery

The negative impact of Acidin-pepsin on the speed of psychomotor reactions and nervous system not identified.

Pregnancy and lactation

Acidin-pepsin is used with caution to treat pathological conditions of the digestive system during pregnancy and lactation. The drug may cause problems with the gastrointestinal tract in a newborn baby or negative reaction from the immune system.

Use in childhood

IN pediatric practice Acidin-pepsin is approved for use in children over six years of age.

For impaired renal function

There are no contraindications for the use of Acidin-pepsin in the list pathological conditions kidney

For liver dysfunction

There are no special instructions for taking the drug in the presence of liver disease.

Conditions for dispensing from pharmacies

Over-the-counter sale.

4. Storage

The medicine should be placed in a place where the temperature will not exceed 25 degrees. In addition, the room should be cool, dark, and dry. Compliance with these requirements is a prerequisite.

If all conditions are met, the drug can be used for 1.5 years. Expired medication is not allowed to be taken. It should be disposed of immediately by placing it in the trash.

5. Price

The price of the medicine must be checked at a specific pharmacy or online store. The article presents average cost around the country.

The price of the drug Acidin-pepsin is based on a whole list of factors, which includes the markup of a pharmacy or online store, the region of sales, as well as transportation costs.

Russia

The price in Russia ranges from 160 to 185 rubles.

Ukraine

The cost of the drug Acidin-pepsin was set at 67.89 hryvnia.

Video on the topic: Digestion in the stomach and intestines