Can a person's blood type change during a person's life? Can a person's blood type change throughout life?

However, you can often hear from people that they had one group, but after a while they became another. This is especially often stated by women during pregnancy, as well as people who have suffered from certain diseases.

Doctors give a simple explanation for this: an incorrect result in laboratory tests. It is believed that in the past, errors in determining group membership were more common. Nowadays, reagents have become of higher quality and the results are more accurate.

What is blood type?

Today, the world has adopted a classification according to the AB0 system, according to which there are four groups:

0 (first) – there are no antigens on the surface of red cells, antibodies α (anti-A) and β (anti-B) are present in the plasma;
A (second) – red blood cells contain anti-A on their membrane, plasma contains β antibodies (anti-B);
B (third) – there is anti-B on the surface of red blood cells, and α antibodies (anti-A) in the plasma;
AB (fourth) - since there is antigen A and B on the membrane of red blood cells, there are no antibodies either α or β in the blood.

Each agglutinogen has its own antibody (agglutinin), which will cause red blood cells to stick together.

Thus, there are a huge number of combinations. Today, two most important classifications have been adopted. This is the AB0 system, according to which group membership depends on combinations of antigenic components on red blood cells. The Rh system (Rh factor), according to which blood differs in the presence or absence of a special protein on the membrane of red cells and can be Rh positive or negative.

Why might it change?

The group is determined by the adhesion of red blood cells. To do this, serum containing antibodies (agglutinins) α, β, α and β are dripped onto a special plate. Then a drop of blood is added to each, and there should be about ten times more serum. After this, the agglutination reaction (sticking together) of red blood cells is observed under a microscope for five minutes. Based on the results of this reaction, the blood type is determined:

if gluing did not occur in any serum, then it is I;
if the reaction is positive with sera containing α and α+β antibodies, then this is II;
if agglutination occurred in serum with β and α+β antibodies, then this is III;
if all sera give positive results, this means that the blood contains both antibodies and belongs to type IV.

Blood group determination

Why might the group change? To do this, it is necessary that red blood cell antigens cease to be produced or their production is greatly weakened. There is an opinion that this can happen with infectious diseases, pregnancy, tumors, and some diseases associated with increased production of red cells. In this regard, in laboratory tests, antibodies cannot detect such a small amount of antigens or the reaction is so weak that it is not visible. Thus, under certain conditions, a temporary change in test results is possible, but not a change in group membership.

Conclusion

We can conclude that a person’s group will not change either with age or for other reasons. Moreover, the combination of antigens, which is already present at the first stage of intrauterine development, cannot change either during pregnancy or after childbirth.

If the analysis shows that the blood has changed, it is most likely worth talking about an error during the laboratory test. In addition, the study result may be associated with weakly expressed antigens. In this case, repeat tests using other reagents are usually prescribed. Thus, it is worth clarifying once again that it is not the blood type that has changed, but the test results.

As a child, I had the first group, at school the same way, now I’m 28 years old and my blood type has changed to 3. I don’t know why this is so, I’m a guy, pregnancy disappears.

In the same way, it was 1+ and became 3+.

Was II(A)+. I was tested many times (maternity hospital, hospitals before surgery, military registration and enlistment office, enlistment in the authorities). I was still wondering why there was so much.

And now, at 35 years old, I’m getting ready to have surgery to fix my nose, I pass 1(0)+. In panic, I run to another clinic 1(0)+. In the third - 1(0)+. In about a month. At the next medical examination I asked for a test - 1(0)+. In another clinic 1(0)+.

Andrey, hello, same story. And no one can give a clear answer. But I was diagnosed with type 2 diabetes, but after changing my blood type. Everyone is saying that this is not possible. That this is a mistake, but I double-checked it several times, just like you..

I also changed from 2 + to 1 -

When I was a child, I had surgery every year in Germany. Group 1+ was. The operation took place under general anesthesia. With a bunch of doctors and drugs. At the age of 27 I went to get tested. They said I had a 2+. Strange. I’m still tormented by the question of whether the Germans in Germany got something wrong with their accuracy, or whether the analyzes are not correct anymore.

When I was pregnant with my older daughters, the blood group was 3+, but when I became pregnant with my third daughter, the blood group became 4-. The birth was natural, no blood was transfused. It's very interesting why this happened.

I also have 4+ blood type. During pregnancy, I took a blood group test, and it was 1 - negative. I retook the exam and now I’m waiting for a second answer, I’m sure there’s some kind of mistake.

The blood type can only change if the synthesis of antigens is stopped/severely weakened, they are no longer on red blood cells. Why can the synthesis of certain antigens be stopped/severely weakened? For several reasons. To describe them, let's look at the quotes:

Previously, there was no doubt that blood type, like fingerprints, remains unchanged throughout life. But it turns out that this is not so.

The ABO phenotype can change in a number of infections. Some bacteria secrete an enzyme into the blood that converts the A1 antigen into a B-like one. This enzyme splits off some part of antigen A, the remaining part becomes similar to antigen B. If a patient is given a blood test at the time of illness, you can get a false result - the test may show blood group B. But at this time the person should not be infused with blood group B , since his blood plasma still contains antibodies to it. After a person recovers, the red blood cell phenotype returns to its original one. It turns out that, from the point of view of laboratory analysis, such a disease is accompanied by a temporary change in blood type.

Any disease associated with increased production of red blood cells - for example, thalassemia - can also weaken the amount of ABO antigens on the surface of red blood cells. In such a situation, a laboratory analysis may show that a person has blood type O. Antibodies in a test tube will not “find” the insignificant amount of remaining antigens A and B, or the reaction of their interaction will be invisible.

Antigens of the ABO blood group can also change during the development of tumor blood diseases.

Do not make me laugh. The one you were born with and live with, it’s just that the quality of blood type determination has actually become higher. Just as I was born in 1964 in Lithuania with 1+ and now I’m 1+.

Do not make me laugh! She gave it up! Just a coincidence, most of them are like that, by the way! People talk about changing their blood type for a reason. I donated 4 times in the era (as you say) of qualitative determination of blood type. Twice it was 1+, twice it was 2+. And everyone like that (like doctors) says to each other: the previous ones were mistaken! My father is from 1+, my son is from 1+. Damn, who to believe, tell me, Irina, since you are so advanced.

Good afternoon, what blood type is your mother? If the father and mother have the first blood group, then yours will also be the first and cannot be any other.

I donated blood as a donor, there was 1 gender, I started taking tests for the operation and it turned out to be 1 negative. Mysticism.☺

This is just understandable. The fact is that for patients or those preparing for surgery, Rh is determined only by the D-antigen, and donors are examined in more detail - if the donor’s D-antigen group is determined to be negative, his blood is also tested for two other Rh antigens - C and E. And if at least one of them is positive, then such a person as the DONOR will be Rh-positive, and as a recipient - Rh-negative. I often encounter this in my work; transfusiologists and laboratory doctors encounter this situation quite often.

Until I was 16 years old I had a 3+, after 2 years when I was drafted I got a 4-, I was told that there might be a mistake! Question: Have civilian doctors been making mistakes for 16 years, or have military doctors been making mistakes for 9 years?

Even at school, during a medical examination, I was given a 2+, then in my second year of university I was hospitalized - again a 2+, 10 years later (in 2014), I had an operation - I took tests, they gave me a 1+, I retook it three times, I didn’t believe it. 1+ all the time). Now I’m 30, I’m being monitored, I donated blood again - 1+. But my mother says that this cannot be - at birth I had a 2+. here's how and who to trust?))

Go to the laboratory, explain the situation, ask to do the analysis in front of you, and let them carry out parallel studies of the obviously known 1st and 2nd groups. And you can see for yourself what blood type you have. I am sure the laboratory staff will not refuse you.

It was 2 on the card from birth, and I was in the hospital at school - it was 2. The pregnant woman passed and the result was 3+. How so? The funny thing is, my husband was undergoing surgery - there was 1, today he took the results (from the LCD he had to give them too) 3+ too. The analysis was done in different places, I retook it in another place, also 3+. Well, how is that?)

I'm also tormented by this question. Before military service, they were forced to undergo surgery (while still in school) - 4(-) (regional hospital); in conscript service they donated blood for Chernobyl victims - 4 (-) (military doctors); contracted appendicitis at a military school - 4(-) (city hospital); . years have passed. when donating blood for your son - 2(-). I run to the head of the department - “error, double check!” They rechecked (this was at the regional blood transfusion center) - 2 (-).

4 years ago I had group 2+, and a year ago it became 1+, now I’m pregnant and the doctors say 1+, but it can’t be that the blood type has changed, the doctors’ answer.

Hello everybody! I also have an incident: I donated blood when replacing my license and it was 2 positive. I was a donor: also 2 positive. 2 years ago I got into an accident, was pulled out of the car in a comatose state, and when checked in the hospital - 4 positive. When he left, he rechecked and again - 4. And who will answer?

I never tested my blood type, but I always knew that it was 3+, since my mom and dad were 3+.

Today I received the results, I have 4+. But this cannot happen, if both parents have 3 grams, then the child cannot have 4 grams. The laboratory claims that they could not have made a mistake.

I have the same situation, I lived with a 3+ for 24 years, and after I became pregnant, the group changed to 4-, they explained this to me by the fact that my husband has a 3-, so it changed for me, now I live with a 4-.

My mother and father have 2+, and I have 3+. Could this be possible? At the age of 5 I had a serious operation on my lungs. Maybe this is the reason?

This is a medical mistake; the blood does not change.

And it’s actually funny for me: I have 2+, my husband has 3+, my son was born, in the maternity hospital they said 2+. At the age of 11, he needed surgery, they donated blood-4+. And my daughter was born -3+, became a donor at about 19 years old, it turned out that she had a 2+.

Until I was 23 years old, I had blood type 1+. She donated blood several times. I donated blood during pregnancy and it turned out to be 3+. And then, back in 1978, they told me that my blood type could change.

And there is no need to say that the tests were done incorrectly. The analysis cannot be a mistake. If only he had been there once, in one place. So, as in the joke: sorry, we don’t have bananas.

My son was born with blood type 2+, and 21 years later doctors claim that he has 4+, how can this be?

Born with group 2+, went to school group 2+, was in the hospital at age 10 group 2+, needed surgery group 1+, second time surgery group 1+, went to college group 1+.

Mom 1+, Dad 2+. How is this possible? I went to many hospitals, talked to biologists, did repeated tests, there is no error, my blood type is 1+, but until I was 10 years old it was 2+!

No one can give the answer! Doctors do nothing but shrug their shoulders, to no avail.

I also have such a funny situation, I was born in 1995, they already took tests there, the indicators were good, so there you go. Mom has 4 (-), dad has 3 (+), and I had 4 (+) until I was 18, I was tested many times and did not suffer from many childhood diseases, just like my mother. I became a donor at the age of 19 and was given a 2(+), and I am still a donor to this day (I’m 23). The blood didn’t change anymore, I’ve never been pregnant, it’s interesting, isn’t it?!

that is, GOD created man! and there is nothing we can do to change this.

Change of blood type

At my birth, I was assigned blood type III+ (father I+, mother III+), which was indicated in the extract. Accordingly, all my life they thought that I had group III. A year ago I was in the hospital with suspected appendicitis. After discharge (already at home), I read in the certificate that they indicated I+ blood type. I decided that they either made a mistake or mistyped it. Moreover, there was a large influx of patients, and my mother claimed that 100% were the third group.

I am currently undergoing tests to register for pregnancy. Today the blood type results arrived. And there I+.

Mom is shocked and forces me to retake the test. I'm completely confused.

Can my blood type change during my life?

at the same time, the child has +, the “father” has -. Well, there’s no way I can be with -

On the pages of the Mail.Ru Children project, comments that violate the legislation of the Russian Federation, as well as propaganda and anti-scientific statements, advertising, and insults to the authors of publications, other discussion participants and moderators are not allowed. All messages with hyperlinks are also deleted.

The accounts of users who systematically violate the rules will be blocked, and all messages left will be deleted.

You can contact the project editors using the feedback form.

Topic: Can blood type change? For example, during pregnancy.

Now I’m 21. At my request, I had a blood test done 3 times. All 3 showed that the 1st was +. How so.

This is a serious question! What if, God forbid, there is a conversation about transfusion?! And who to trust? Old technology, but excellent specialists. Or today’s new technologies, but doctors and specialists cannot be called!

Andrey Petrochenkov, abdominal surgeon, Smolensk

forum, email () -100 rubles consultation

telephone - 300 rubles ()

skyrubley (petro148676)

Tags for this topic

Your rights

You can create new topics
You can reply to topics
You cannot attach attachments
You can not edit your posts

BB codes Included
SmiliesOn
Code On
code is On
HTML Code Off

© 2000-Nedug.Ru. The information on this site is not intended to be a substitute for professional medical care, advice and diagnosis. If you notice symptoms of the disease or feel unwell, you should consult a doctor for additional advice and treatment. Please send all comments, wishes and suggestions to

Oh God! Can your blood type change during pregnancy?

I always had group 3 in all tests. I took the last test for antibodies and what a surprise it was for the midwife who analyzed the tests and naturally mine when it was written in red paste “IN THE TEST TUBE BLOOD OF GROUP 3- NOT DETECTED, DETECTED 1-”

How shoud I understand this? Tomorrow morning I’ll go and re-issue it, but I’ve heard rumors before that the blood type can change during pregnancy if the mother and fetus don’t have the same blood type. The mother will take the baby's blood type.

Has anyone encountered this or is it a lab error?

P.S. For those who are still answering.

Girls, I had a mistake in my tests! The test tubes were mixed up. They checked it twice more - 3-. The child was checked at birth - 3+.

And your theory is interesting)))

Mother and child never exchange blood.

But my mother’s blood changed (before or during, I don’t know).

therefore - a living example =))), but there is still a point... some groups are very similar in composition and the most accurate result is given only in 2 cases:

1. expensive reagent

2. do a test within the next few minutes after blood sampling

copied the doctor's answer from the site

This is basically impossible. Blood type is determined genetically and never changes; it is the same throughout life. Neither pregnancy nor other factors can change it

In fact, it is very important to know what your blood type and Rh is. I also want to put a stamp in my passport, otherwise you never know how they will determine it incorrectly and then by mistake in a critical situation the wrong blood will be poured in... Likewise, the hooves can be discarded by mistake... I’m personally afraid... no one knows how the birth might end.

Our blood type and Rh factor are given to us at birth once and for the rest of our lives. They cannot change.

Source: Medical Reproduction Clinic “MA-MA”

Mom won't miss

women on baby.ru

Our pregnancy calendar reveals to you the features of all stages of pregnancy - an extremely important, exciting and new period of your life.

We will tell you what will happen to your future baby and you in each of the forty weeks.

Can your blood type change?

Even while still in the womb, each person receives his own blood type and Rh factor. These are characteristics that are transmitted at the genetic level, like eye or skin color, and do not change throughout life. After all, we know that a person’s eye color cannot suddenly change throughout his life, and this is a fact. Just like blood type or Rh factor. However, there are opinions that the blood type can still change. Such cases allegedly occurred among pregnant women or people who had suffered any disease. Knowing that this is impossible, the first thing that comes to mind is, of course, a poorly performed blood group test. Let's try to figure it out: can such a change in blood type really happen?

What is blood type

Human blood is a substance with a unique composition. There are many system options for designating blood group, but most often in medical practice two of them are used:

AVO system;
Jansky system (familiar to everyone I, II, III, VI blood groups).

The main function of agglutinins is the connection of molecules of bacteria, viruses and other foreign substances. The location of agglutinins is the blood plasma, and red blood cells (or red blood cells) contain special substances that contribute to their formation. These substances are called agglutinogens. In humans, there are two types of agglutinins - a and b, and two types of agglutinogens (antigens) - A and B. Their different combinations form blood groups. So, there are the following options:

Blood group first (or zero), which is designated as O: the membrane of red blood cells does not contain agglutinogens, but the blood contains antibodies a and b.
The second blood group is designated A: the erythrocyte membrane contains antigen A and antibodies b are present.
Blood group third, which is designated as B: the membrane of red blood cells includes the B antigen, and the blood contains antibodies A.
Blood group is the fourth, which is designated AB: the membrane of red blood cells has antigens A and B, but lacks antibodies a and b.

Don’t forget about the Rh factor (Rh), a special protein that is located on the membrane of red blood cells:

The protein is located on the membrane of red blood cells, which means that it is Rh positive (Rh+).
There is no protein on the membrane of red blood cells, which means Rh negative (Rh-).

The opinion of scientists about the presence of these antibodies and antigens in the blood boils down to the fact that they are traces in the blood of viruses and infections transmitted during life by our ancestors. Blood type can be determined using a blood test. To do this, sera containing antibodies a, b, a and b are taken, human blood is added to the sera and the reaction of red blood cells is observed (agglutination, i.e. the joining process). Based on the results of agglutination, the group is determined. Thus, blood of the fourth group will not cause the union of erythrocytes, and agglutination of erythrocytes of the first group will be observed in each of the sera.

Why can your blood type change?

As already mentioned, human blood is an innate trait and a set of certain agglutinins and agglutinogens encoded by genes. Like any genetic component, blood type does not change. However, a person's blood type can be changed for the following reasons:

An error in conducting an analysis to determine a person’s blood type.

Despite the apparent simplicity of the test for determining blood type, the possibility of error cannot be excluded, which leads to the fact that a person’s blood type can change at a certain stage of life.

During pregnancy, the production of red blood cells increases greatly, but at the same time the concentration of agglutinogens decreases so that the connection of red blood cells containing them does not occur. In this case, a person may be found to have the first blood group, although in fact he has the second, third or fourth.

During some diseases, the content of red blood cells may increase as much as during pregnancy, causing the blood type to change. In addition, some of the pathogenic bacteria and microbes secrete enzymes that change the composition of agglutinogens A in such a way that they become similar to agglutinogens B. In this case, the analysis will show the third group instead of the second. Interestingly, transfusion of type B blood to a person will still be impossible and may cause an incompatibility reaction. This cannot be done because blood group B antibodies will still remain in the blood plasma. After treatment, the red blood cells will again contain only A agglutinogens. Thus, a change in blood group is a temporary phenomenon in this case. Cooley's disease (thalassemia) can reduce the number of antigens on the membrane of red blood cells. The analysis can show the first blood group, since the amount of agglutinogens A and B will be so insignificant that it simply cannot be detected, and the agglutination reaction will be weak and imperceptible. Blood cancers (leukemia, hematosarcoma) can also change antigens in the blood.

Does a person's blood type change over time?

Everyone knows that a person’s blood type is an innate characteristic of the body and is also inherited genetically. Can a person’s blood type change during life? This is a question many people ask. If we remember biology, we can safely say that the answer will be negative. However, there are contrary statements in society.

Quite often you can hear that when taking a blood test, for example, the first blood group is determined. Some time after the repeated examination, it turned out that the blood type had suddenly changed. For example, she became fourth. What to do with such statements? Ignore it? Blame everything on the mistake of an unscrupulous laboratory assistant? Of course, this fact cannot be completely excluded and such a possibility exists, but you still need to try to understand the possible reasons for changes in a person’s blood type throughout life. I wonder why this happens and most importantly, how?

What is blood type?

A blood group is a set of characteristics of its elements. Which ones? Red blood cells, platelets, leukocytes. Everyone has heard about them, and even knows something about the norms of their content and functions in general terms. But few people know that a person has sets of antigens in his blood (there are about 300 of them), as well as plasma proteins.

Currently, many blood group systems are known, but in practice not everyone uses them in medicine. Only two of them: the ABO blood system and the Rh factor. In blood group qualifications, they are considered the most important, since they are the most active and noticeable.

The AB0 blood group system consists of agglutinogens (A and B), which are found in red blood cells and cause the formation of agglutinins α and β (alpha and beta). Agglutinins are antibodies that glue bacteria, viruses, etc. together.

With various combinations of antibodies and antigens, 4 well-known blood groups are formed: the presence of A and B without agglutinogens indicates the first group, A and β - II, B and α - both agglutinogens without agglutinins - IV.

Blood group classification

Rh factor

Determining a person's Rh status is done by detecting the presence of the Rh antigen (protein) located on the surface of the red blood cell. 85% of people have this antigen on their red blood cells and are classified as Rh positive. The remaining 15% of people do not have this protein and are classified as Rh negative.

The absence or presence of protein in the blood does not mean any pathology. This is a sign of individuality that is inherited and cannot change in any way throughout life.

Why do you need to know your blood type?

You need to know your blood type and Rh factor! For example, this may be needed during a procedure such as a blood transfusion, or for a pregnant woman who is preparing to become a mother. Moreover, it would not hurt future parents to take care of this even at the stage of pregnancy planning.

The thing is that this knowledge will be useful for identifying the compatibility of blood groups during pregnancy. This has a significant impact on how the pregnancy progresses and the occurrence of adverse effects in both mother and child.

Blood group compatibility table

Rhesus conflict

Rh conflict during pregnancy occurs only if the mother's blood is Rh negative, and the baby can inherit the father's Rh positive blood.

This is what happens: the baby’s blood is mistaken for a foreign substance, since it is unfamiliar to the mother’s body. The active production of antibodies begins, they begin to attack the baby’s blood cells.

In order for the fetus to be protected, it is enough to vaccinate with anti-Rhesus immunoglobulin. Such a vaccine will bind antibodies produced in the mother’s body and release them. Immediately after birth, a child with an Rh-conflict pregnancy is given a blood transfusion. After the transfusion, the mother's antibodies are neutralized.

There is no need to worry if a woman is Rh negative. Rh conflict during pregnancy is quite rare, but nevertheless too dangerous. Still, very often Rh-negative mothers quietly carry the fetus throughout their pregnancy.

Table of Rh conflict during pregnancy

Is it possible to change group

All experts categorically and unequivocally state that the blood type remains unchanged throughout a person’s life. However, the following clarification is added: under normal living conditions. What does it mean?

Cases have been recorded in which red blood cells A and B can express themselves extremely weakly. This situation often occurs in people who have blood leukemia. This is the so-called blood cancer. This category also includes people suffering from any other diseases of malignant etiology. All this leads to the fact that the total number of natural antigens becomes smaller. Thus, subsequently, when performing an analysis to determine the blood group, these antigens begin to express themselves extremely weakly.

So it becomes clear that cancer patients have almost no opportunity to correctly determine their blood type, and often even the Rh factor. This fact does not mean that the blood type has the ability to change throughout life. This only means that the determination of the blood group did not give a completely correct result and was inaccurate. The reason for this was changes occurring in human blood. This is due to the fact that in people with cancer it is very difficult to find proteins on the surface of red blood cells, the number of which has been significantly reduced due to the disease.

It is also known about the existence of certain pathogenic microbes. They are capable of secreting enzymes. And the latter, in turn, have the ability to change the composition of agglutinogens A and, in this regard, make them similar to B. Then the blood type is interpreted erroneously. The analysis will show blood group III instead of the correct II. When a person recovers and retakes the test again, all indicators return to the normal state that was before the illness.

Thus, from all of the above, the conclusion follows: a person’s blood type cannot change during life, under normal conditions.

It is known that blood type is an innate characteristic of the body and remains unchanged. Only in some diseases are different results possible, but this is still an erroneous definition of the group, and not a change in it. Since diseases have created conditions that make it difficult to determine the group and lead to errors in the analysis. We hope we have given you the answer to whether the blood type can change over time in a child and adults over the course of a lifetime.

Have questions? Ask them to us on VKontakte

Share your experience in this matter Cancel reply

Attention. Our site is for informational purposes only. For more accurate information, to determine your diagnosis and how to treat it, contact the clinic for an appointment with a doctor for a consultation. Copying materials on the site is permitted only with an active link to the source. Please read the Site Use Agreement first.

If you find an error in the text, select it and press Shift + Enter or click here and we will try to quickly correct the error.

Subscribe to our newsletter

Sign up to our newsletter

Thank you for your message. We will fix the error soon.

I have a similar situation now. The first B was diagnosed as Rh-negative, and after the birth she was injected with immunoglobulin (child +). I registered as 2B in LCD No. 1, before that I was at 4, the Rhesus came negative for the first time, and the subsequent ones with the postscript Du, the doctor said not to pay attention, and now the 28th week comes and the Rhesus comes positive. I retake the test - positive. I talked to a doctor from the blood center, she said that they are now looking at other reagents, in which the D antigen can be seen even in small quantities, and he is already talking about positive Rhesus. In short, I’m still in shock, because even at Euromed I took this test 3 years ago, and it was negative. I'm still waiting for a meeting with a perenatologist, what will she say?

So, it's all about the reagents. Write down what the doctor says later. I recently retook it again, so far it’s positive)

Most likely it is a weakly positive Rhesus. Sometimes they write Rh"D". However, the analyzes give different results. Sometimes +, sometimes -. 1% of people have this “third” Rh. There are three of them in my family))

Wow. Thanks I'll know

terrible. Yes, it seems like this is an elementary analysis, how can you make a mistake there. And they always check it in hospitals, why didn’t they check it for you during the disease? Some kind of negligence, honestly. It’s good that at least by 36 weeks the situation has cleared up)))

Yes, after digging through a bunch of information, I realized that the Rh factor and blood type never change. There are just hand-assed laboratory assistants!!

Well, at least your post is sound about not always blindly trusting our laboratories, they can make mistakes and do so often. And then yesterday there seemed to be a post about how many people change not only their Rhesus, but also their group))) and they believe that it really changes))))) You just need to double-check everything a hundred times.

It follows that in some people it is almost impossible to accurately determine this characteristic in a typical way. Those. it cannot change, but may be inaccurately defined. This is due to the difficulty of finding those same antigens on the surface of red blood cells. Their complete disappearance may indicate some kind of disease, including acute myeloid leukemia. However, the blood type itself does not change..

Antigens such as A and B of the AB0 system contain carbohydrate molecules connected in chains. To carry out this process, the enzyme glycosyltransferases is required. In patients with acute myeloid leukemia, the activity of this enzyme changes and becomes lower. This is why antigens on the surface of red blood cells may not be detected.

In connection with the above, we can draw a conclusion and give a final answer to the question: is there a possibility that the blood type has changed or can it change at all? No. There is a possibility that an error was made in some of the studies. It is also possible that one of your AB0 antigens is weakly expressed, which is a reason for repeated tests using additional reagents«.

Previously, there was very little information about Rh conflicts, homolytic disease, etc., so they could not save the babies. Needless to say, even now not all clinics administer immunoglobulin

Throughout my first pregnancy, I thought that I had a 3+ (and even during pregnancy there was surgery and I was unscheduled to have all these tests done again), and when I gave birth, the doctor called me to be injected with immunoglobulin. I ask why, I’m 3-. How can this be? And now I’m pregnant for the second time and I’m 3-. They say this happens.

No, everything was right. It was just weakly positive, but now it seems weakly negative. That's all.

This is my headache at the moment. My son is now 5 years old. The entire pregnancy with him was with group 1 negative Rh factor. I tested for antibodies. Immediately after giving birth, I was injected with immunoglobulin. After some time has passed, the start.

I went to a scheduled appointment with my doctor, where the doctor shocked me with the news that I have a 3rd negative blood group and we will be injecting immunoglobulin at the 28th week. My eyes on his news cost 5 rubles.

Hello girls! I'm getting ready for the protocol. The question is, can the Rh factor change? The fact is that my Ryo ordered me to retake the blood type test. According to the previous analysis, which I took a year ago, the group.

Who is talking about what, but I can’t figure everything out with my tests) I lived quietly until I was 27 years old and thought that I had a + Rh factor. This is my third pregnancy, I’m registered with the housing complex.

All my life my blood was negative. I gave birth to two children who were positive, I didn’t inject anything, I just monitored the antibody titers. The older one had jaundice for several days, the younger one for almost a month. I was worried about the third one, but only a little, for some reason I was sure that everything was in order. Registered among.

I was preparing to take anti-Rhesus immunoglobulin in June. On June 2, I donated blood, yesterday I had an ultrasound, according to which everything was fine, the baby was within 1 week, and I went to the appointment happy. And there on you (((antibodies to the Rh factor were detected.

Who took a blood test to determine the child’s Rh factor before receiving an immunoglobulin injection? Where was it made in Moscow? I called well-known laboratories, but they don’t do it. When can it be done, only after 26 weeks?

My Rh factor has changed. Either it's a mistake or I don't know what. At birth, my blood was 2 negative, well, in fact, I lived with it all this time. Until I had an analysis done, in which...

Hello girls! During my first pregnancy, tests determined my blood type and Rh 3 positive (twice). Now I’m 12 weeks, test 3 came back negative! How so! I'm shocked. Was there a

The story in brief. Everyone knows that the blood type and Rhesus do not change throughout life, unless it is a blood transfusion. As soon as I became pregnant, spotting, bleeding, hospitalization and preservation immediately began. Not counting several miscarriages in the early stages. I will write right away, that my husband has 2+. In February.

Even from the biology course at school, we can tell what a blood type is. It represents a number of genetically inherited traits that cannot change in the natural environment. That's why, if you are wondering whether your blood type can change, then a positive answer is unlikely. It combines a set of molecules: red blood cells or agglutinogens of the ABO system. The latter are found both in red blood cells and on some cells of various types of tissues, and are even found in saliva or other body fluids.

In the first stages of intrauterine development, antigens of the AB0 system are already present, and by birth there are already many of them. The AB0 set cannot change even before birth.

With different quantitative combinations of antibodies and antigens, 4 groups are identified:

Group 0 (I) – the presence of agglutinogen H on erythrocytes, where it is an incompletely formed agglutinogen B or A. Plasma contains alpha and beta agglutinins.
Group A (II) – erythrocytes contain only agglutinogen A, plasma contains only agglutinin beta.
Group B (III) – erythrocytes contain only agglutinogen B, plasma contains only agglutinin alpha.
Group AB (IV) – A and B are present on red blood cells; agglutinins are not present in plasma.

In some cases, there may be errors in determining this characteristic of your blood. This is due to the possible weak form A. Sometimes this leads to blood transfusion accidents. Sometimes, for a more accurate determination of weak A antigens, it is necessary to use special reagents.

Rh factor

For a more accurate determination, a person’s Rh factor is determined. This determination occurs thanks to the Rh antigen, which is also located on the surface of red blood cells. In medicine, there are 5 possible rhesus diseases. The main one is Rh (D), which allows you to determine whether a person has a positive or negative Rh factor. In the absence of this antigen, a negative Rh factor is determined; if detected, it is positive. This characteristic of your blood also cannot change throughout your life.

There are also less strong antigens in the Rh system. There are even cases of the formation of anti-Rh antibodies with a Rh-positive factor. These individuals have weak forms of D, also called Du. The percentage of this opportunity is small and amounts to about 1%. People who have it are required to receive a blood transfusion with an exclusively Rh negative factor, otherwise an Rh conflict may occur.

Donors with Du are considered Rh-positive, because even weak Rh (D) can also cause Rh-conflict in Rh-negative recipients. In case of Rh conflict, a patient with a negative Rh factor begins to produce antibodies against them, which can lead to the destruction of red blood cells.

When transfusing blood, it is necessary to strictly adhere to the group affiliation of the donor and the patient. To do this, before transfusion, it is necessary to accurately determine whether each of them belongs to one or another blood group. The best way to do this is to use a cross reaction. And this trend does not change over time.

However, in emergency situations, transfusion may be acceptable with some inconsistencies. Thus, red blood cells found in group 0 blood can be transfused into recipients with other groups. However, the use of whole blood is unacceptable. Red blood cells belonging to A can be transfused into patients with A or AB. Red blood cells belonging to B can be transfused to patients with B or AB. If a risk of Rh conflict is detected in a mother and child, it is necessary to take special measures, otherwise the child may be born with homolytic disease of the newborn.

So why is there an opinion that it is impossible to change your blood type under normal conditions?

When molecules of group antigens are formed, proteins are synthesized on the surface of red blood cells. The structure of a protein is determined from information that is taken from DNA. Each gene produces its own protein, which is part of a specific DNA fragment.

The ABO gene can imply 3 options for the development of events: A, B and 0. If a person has genes A and B at the same time, then AB (IV) will be determined. If any one gene A or B is present, A (II) or B (III) is determined accordingly. Group 0 (I) is determined if two 0 genes are inherited. It is determined at conception and does not change throughout life.

The Rh factor is determined by the presence of the D and d genes. Among them, D is dominant. Therefore, in situations of inheritance from one parent D, and from the second D, a positive Rh factor will be detected. Those. variants DD and Dd receive positive Rh and only dd - negative, and they will not change throughout life.

Options for the development of abnormal conditions

It happens that the determination of the blood group is not entirely accurate. Sometimes it may have some restrictions. There are cases when red blood cells A and B express themselves very weakly. Most often, this situation is observed in patients with leukemia or some other malignant diseases. Patients who have some kind of neoplasm or suffer from some kind of blood disease may have a decrease in the amount of natural antigens in the plasma.

So why does the red blood cell show the absence of ABO system antigens?

Laboratory tests occupy an important place in the timely diagnosis of various diseases of internal organs. Among them, blood tests stand out, especially blood group, since it is this that should be taken into account when carrying out various operations and transfusions.

A blood group is a set of special antigens that are located on the surface of red blood cells.

A – is responsible for the inheritance of blood group 2;
B – is responsible for the inheritance of blood group 3;
0 – “zero” antigen, indicating the absence of 2 of the above groups.

The combination of A and B causes the appearance of group 4. Normally, this antigenic composition does not change.

Blood inheritance is determined by genes, each of which is responsible for the production of certain proteins. Throughout a person’s life, these genes produce the same proteins, i.e. constantly, a group of surface antigens is determined.

That is why some researchers often ask the question: is it possible to change blood antigens? Does it change over time?

Can your blood type change?

As mentioned above, inheritance of blood type is carried out through the synthesis of peptides, the formation of which is determined by genes. Theoretically, if the structure of a gene changed and it began to produce a different protein, the body would acquire a new trait associated with this molecule.

Thus, if the nucleotide sequence in the structure of the gene responsible for blood changes, a different group can be obtained. But this is only in theory.

In practice, such a change in the gene structure will not lead to a change in blood type, but will cause a cascade of immune reactions. If in a healthy body the antigens that are responsible for the inheritance of blood are not attacked by their own antibodies, then when the structure of the antigens changes, they will be attacked by lymphocytes, which will lead to massive death of red blood cells and hemolysis, which will end in death.

Otherwise, a person will experience excessive agglutination of red blood cells, which will cause the development of thrombosis of the vessels of internal organs, the development of their necrosis and multiple organ failure, which poses a significant threat to the patient’s life.

However, in clinical practice, incorrect determination of blood group may occur. What are its main reasons and why do such errors occur in research?

Why can analysis results be misinterpreted?

The blood test process can be divided into several stages:

at the first stage, blood is collected from the patient and transported to the laboratory;
The second stage involves direct determination of the group using laboratory methods;
At the third stage, the results are interpreted and a conclusion is made regarding the patient’s blood condition.

What mistakes can be made at each stage? At the stage of taking samples from a person:

The most common reason for incorrect blood group determination is medical personnel error. Sometimes, there is confusion in the analyzes obtained, the test tubes can be swapped, and therefore, instead of the expected group, a completely different one is obtained;
In second place in terms of frequency of occurrence is dishonest processing of test tubes;
The third reason the group changed was the mixing of samples during transport to the laboratory (due to the fact that they are all usually in the same container).

The second stage is a direct study of the analysis, which is carried out either using monoclonal antibodies or using standard sera. The result may also change:

due to inconsistent addition of sera to the patient sample, which introduces confusion during the study;
The use of low-quality or expired reagents also leads to diagnostic errors and incorrect determination of the antigenic composition.
Considering that all reactions must be carried out under strictly defined conditions, changes in lighting, humidity or ambient temperature may distort the results obtained.
The error may occur due to the use of low-quality equipment.

At the third stage, mistakes are made extremely rarely. Most often, errors in analyzes are made as a result of the “human factor” - a tired laboratory diagnostic doctor can easily enter the wrong group into the analysis form, which will lead to further errors and can lead to serious consequences and a threat to life (especially if the patient requires a blood transfusion). result of the operation).

Less common causes of misdiagnosis

Quite rarely, but it still happens, incorrect group determination can occur as a result of the patient having a so-called blood group subtype or other reasons.

Antigenic subtypes of A-antigen. Each antigen that causes the development of the second blood group has two subtypes - A1 and A2. Each of them has a different ability to agglutinate, which is why diagnostic errors may develop when determining the fourth group. Because of this feature, the agglutination reaction may proceed incorrectly, which will lead to incorrect interpretation of the analysis results (a “false” group change occurs).
Nonspecific clumping of red blood cells. Occurs as a result of the development of an autoimmune process in the body, which provokes excessive agglutination of antibodies on the surface of the red blood cell for a long time. As a result, during a blood test, agglutination may occur in all tubes, which is why the patient will be mistakenly assigned to group 4. Such an error can lead to transfusion of incompatible blood and ultimately lead to systemic hemolysis.
Erythrocyte chimeras. A rather rare phenomenon, usually observed in heterozygous twins in the early years of life. Their appearance is due to the presence in the bloodstream of different populations of erythrocytes, different in group and composition of antibodies. As a result, during the analysis, red blood cells of both one and another group may react, as a result of which the blood type is diagnosed incorrectly.
It is especially important to take this factor into account during transfusion, since if antibodies against his red blood cells enter the patient’s body, massive destruction of blood cells may develop.
The phenomenon of “false chimera”. Develops against the background of severe systemic diseases, as well as sepsis. As a result of the disease, pathological thickening of the blood occurs, which ultimately prevents all the red blood cells taken from adequately entering into the isohemagglutination reaction, causing the result to change. In children, this phenomenon can be observed in the very early years of life, when red blood cells are not yet fully mature.

All these conditions can lead to a “change” of blood type in the analysis, which causes further disagreements and diagnostic errors. Considering all of them, if the blood type has changed, it is necessary to redo this analysis to clarify the information received.

Recently, an acquaintance told me that his wife, while undergoing tests during pregnancy, “changed” her blood type. Was the third, became the first. The logical question is: HOW? After all, the blood type is genetically determined... And it can only change in a spider-man. But, nevertheless, it is a fact: there was a third blood group (according to documents, tests were carried out more than once), but it became the first (a characteristic reaction to the first blood group). So the question still remains: Can your blood type change? By the way, as a survey of friends showed, this is not an isolated case. There is another documented change, but this time in the Rh factor. How? Why? For what?

We will try to answer in this article, which is not in vain placed in the ““ section.

Can your blood type change? What’s most interesting is that if you ask a search engine about this question, you will find a LOT of forums where this issue is discussed. Usually the forum begins like this: “ My blood type has changed... Why?»

This is followed by two different types of responses:

this can never happen (I swear by Mendel!) - the doctors made a mistake (about 50% of answers)
and my/my friend’s blood type has changed (about 50% of answers).

According to reports, the statistics are as follows:

blood type changes are most often recorded in women
This mainly occurs during pregnancy.

Undoubtedly, the possibility of medical error exists; This is why a compatibility test MUST be done when receiving a blood transfusion. So as not to guess, but to be sure. But a mistake is a mistake, and facts are facts: there was one blood type, but it became another. Why?

To answer, let's first understand blood groups.

To make it clear what can or cannot change in a blood group.

So, did you know that not the well-known 4 groups, but hundreds of billions of blood group combinations are possible? And just like that. Why is this so? Everything is very simple.

Certain substances are responsible for blood type, they are called “antigens”.

Why such a strange name “antigens”? It's just an acronym: anti body- gen erating, antibody manufacturer. Antigens are signal beacons for the immune system that it is time to produce antibodies. Antibodies are special molecules whose task is to bind and neutralize antigens. Antibodies LITERALLY bind to antigens, they act like a kind of adhesive mesh. That's why many of them are called agglutinins, adhesives.

Antigens can be external or internal. The most dangerous antigens are parts of the membranes of bacteria and viruses (usually they come from outside). Consequently, as soon as familiar antigens appear in the blood (= attack by microorganisms), antibodies neutralize them. Also an example of antigens are substances that cause allergies.

Each antigen has its own antibody. If the body has never had a certain antigen, then there will be no corresponding antibodies. The antigenic mechanism of immunity is the body's memory of diseases. This is protection for the future. This is how vaccinations work. For new diseases for which there are no antibodies, there are other immune mechanisms.

In connection with blood group, we are interested in internal antigens. These are substances that are attached to the membrane of red blood cells, red blood cells, oxygen/carbon dioxide carriers.

Since there are HUNDREDS of antigens in the blood, hundreds of billions of possible combinations (= blood groups) can be constructed. But in connection with the well-known blood groups (1, 2, 3, 4 and Rh factor), we are only interested in antigens A, B and Rh.

So, in a simplified form, 4 cases are possible:

There is antigen A on the membrane of red blood cells. Blood group is second (denoted A). There are β antibodies in the blood
There is antigen B on the membrane of red blood cells. Blood group is third (denoted B). There are α antibodies in the blood
There are both A and B on the membrane. Blood group is fourth (designated AB). There are no α and β antibodies in the blood
There are no these antigens on the shell. Blood group first (denoted O). There are both α and β antibodies in the blood

Plus two options:

There is an Rh antigen on the membrane of red blood cells. Rh factor is positive (because the substance is present)
There is no Rh antigen on the membrane of red blood cells. The Rh factor is negative (since there is no antigen).

What does this give us? This gives knowledge about the presence of certain antibodies in the blood. And also the ability to predict what will happen if the blood of one group is mixed with the blood of another group. Roughly speaking: there will be adhesion, blood clotting, or not.

So, we remember: for each antigen there is a “personal” antibody that will stick this antigen together.

Hence:

A + α = × (axe head)
B + β = × (axe head)
A, B + α = × (axe head)
A, B + β = × (axe head)
A + α, β = × (axe head)
B + α, β = × (axe head)
A, B + α, β = × (axe head)

Accordingly, if there is already, say, antibody α in the blood, then there SHOULD NOT BE antigen A in the infused blood. Otherwise, there will be agglutination and agglutination. In general, trouble. All patterns with A, B, etc. can be expressed as a table:

			recipient (to whom)
		antibodies	α, β	β	α	0
	antigens	blood type	1	2	3	4
donor (from whom)	0	1	+	+	+	+
	A	2	×	+	×	+
	IN	3	×	×	+	+
	AB	4	×	×	×	+

Or, which is much simpler, with a drawing:

With the Rh factor it’s the same story; the given table simply becomes 2 times more complicated. But this does not scare us; it is important for us to simply understand the antigens. We have tried to illustrate their functions and presence through a description of blood transfusion. We hope we succeeded.

By the way, an interesting question: Why do some people have antigens and others don’t? There is no answer to this question. But there is an assumption: these may be the remains of symbiotic microorganisms (for example, viruses), which during the process of evolution gradually “dissolved” in the body. So, did you know that mitochondria (the energy stations of cells that have their own DNA) are most likely bacteria that long ago, in ancient times, entered into symbiosis with nuclear cells? And so here it is :) Apparently, a similar case is indicated by the presence of certain antigens in human blood.

But this is a digression from the topic. We return:

We are interested in whether it is possible to change blood type during life.

So let's continue. Why are we even talking about the gluing of red blood cells? Because gluing is blood group test.

Blood type is determined using sera containing antibodies α, β, α + β. First, the serum is dripped onto a plate. Then drops of blood are added to the serum. The amount of blood should be 10-15 times less than serum. Next, the agglutination (gluing) of red blood cells is observed through a microscope. Based on the results of gluing / non-gluing (using a table similar to the one above), the blood type is determined. For example, the fourth blood group will not cause adhesion, but the first will in all cases.

Here we come to the key point of our article.

Previously, there was no doubt that blood type, like fingerprints, remains unchanged throughout life. But it turns out that this is not so.

The ABO phenotype can change in a number of infections. Some bacteria secrete an enzyme into the blood that converts the A1 antigen into a B-like one. This enzyme splits off some part of antigen A, the remaining part becomes similar to antigen B. If a patient is given a blood test at the time of illness, you can get a false result - the test may show blood group B. But at this time the person should not be infused with blood group B , since his blood plasma still contains antibodies to it. After a person recovers, the red blood cell phenotype returns to its original one. It turns out that, from the point of view of laboratory analysis, such a disease is accompanied by a temporary change in blood type.

Any disease associated with increased production of red blood cells - for example, thalassemia - can also weaken the amount of ABO antigens on the surface of red blood cells. In such a situation, a laboratory analysis may show that a person has blood type O. Antibodies in a test tube will not “find” the insignificant amount of remaining antigens A and B, or the reaction of their interaction will be invisible.

Antigens of the ABO blood group can also change during the development of tumor blood diseases.

Now let's analyze:

We started the article with fact: a pregnant girl went to the hospital for a blood test, and was surprised that she was transferred from group 3 to group 1.

Fact #2: increased production of red blood cells leads to the fact that there are few specific antigens on their surface (in this case, B antigens), which creates the illusion of O, the first blood group.

Pattern: pregnancy is associated with intensive synthesis erythrocytes (the blood volume of pregnant women increases to 1.5-2 liters, and the number of erythrocytes increases to 130%).

Conclusion: pregnancy, under certain conditions, can lead to a decrease in the number of antigens on the surface of red blood cells, and, therefore, to a “change” of blood type.

The survey showed that among my friends, one woman also found herself with a change in blood type. Only in her case the Rh factor changed (from positive to negative). Proteins that are also attached to the membrane of red blood cells are responsible for the Rh factor. Therefore, we can assume: just like with a false zero blood group, a false Rh-negative blood group is also possible.

Theoretically, after childbirth and with a decrease in blood volume and a decrease in the synthesis of red blood cells, all indicators should return to their places.

Among the data on the forums, there were also other shifts in blood groups (from 2 to 3, from 3 to 4, etc.). It is likely that they are subject to similar mechanisms.

However, the issue of “changing” the blood group has not been studied enough, which is in vain - this change can, for example, be a good diagnostic sign for identifying a number of diseases. So doctors have room for creativity :)

So, the conclusion: blood type can “change” under certain conditions.

There are several hypotheses that explain these temporal changes. The hypotheses have not received sufficient theoretical and experimental substantiation in clinical settings.

Although there are many untraceable and undocumented facts that support these hypotheses.

Perhaps someone has additional information? Be sure to write in the comments!

The magazine Around the World helped to understand the issue: http://www.vokrugsveta.ru/telegraph/pulse/565/

The 21st century is a time that requires strict control over your health. Due to polluted environment, poor diet, and stress, people increasingly began to seek help from a doctor. Blood type and Rh factor are those basic characteristics of the body on which human life in some cases depends (transfusion, organ transplantation, pregnancy and childbirth). Can BG change during life?

This question is periodically raised on the Internet, but getting a definite answer is not easy. Some users write that this cannot be, while others are sure that changing the group is possible. Which one is right?

Groups

Blood type: what's the point?

Before you figure out whether a person’s group is capable of changing throughout his life, it’s worth understanding what the essence of group classification is.

Human blood is a unique biomaterial, which differs from person to person. Its characteristics are determined in the womb.

Types of groups

With blood we receive the set of genetic material that is passed on to us by our father and mother. Direct group determination is a process that detects the presence or absence of specific antibodies in the blood. They are called agglutinins and agglutinogens.

Important! Antibodies are compounds that are created to stick together (agglutinate) various bacteria and viruses in the blood. These are peculiar “fighters” that prevent the development of foreign bodies in the body. It is from this function that their name comes.

HA is a set of special antibodies that is present or not in plasma and cells. Red blood cells - erythrocytes - are capable of producing these substances. The main trigger for the production of antibodies is the presence of antigens. They are divided into two types - A and B. It is these substances that affect the group, which is taken as the basis for the AB0 group classification system. Due to their different combinations, scientists were able to identify four groups.

1 or 0 group. There are no agglutinogens in its composition, but at the same time, this type of blood has type A and B antibodies (agglutinins) in the blood plasma.
Group 2 is designated “A”, this is due to the content of type A antigen. And there must be antibodies b in the plasma.
Group 3 – antigen B and group A antibodies.
Group 4 is a combination of two types of antigens - A and B, while there are no antibodies in it.

This classification is recognized throughout the world, but sometimes people simply have a poorly developed A-form. It is this fact that leads to the erroneous definition of the group.

Important! The group is not capable of changing throughout life, since it is a genetically embedded material that a person receives in the womb of his mother.

This feature can lead to accidents if compatibility is not checked in time. To correctly and accurately determine the group, doctors use special reagents to diagnose blood.

Rh factor

Can the Rh factor change throughout life? It is worth remembering that the Rh factor is an inherited element that cannot change. Only those people who do not know what Rhesus is have an erroneous opinion about this blood feature.

In world history, only a single case was recorded when a young 15-year-old girl had a change in Rh.

Features of agglutinogen

This happened after a liver transplant. She managed to find out about this change in blood only 6 years after the organ transplant. The girl suffered from an immune disease, during the treatment of which a change in Rh was revealed.

Doctors claim that this could only happen for one reason - the donor’s liver contained stem cells that entered the girl’s bone marrow. Her body accepted these substances and launched new immune processes. An additional factor that influenced the change in Rh could be the fact that the donor was a young guy. His blood had a low number of white blood cells.

Can the Rh factor change? The answer for most scientists remains the same - no. This is a genetic trait that cannot change in a healthy person.

Rhesus conflict - what is it?

Rh positive or negative is an individual trait for each person. It does not affect your well-being in any way, but for a woman this fact is quite important if she is planning to get pregnant.

The mother's body perceives the child as a foreign body, and therefore begins active actions to reject it. Antibodies are synthesized in the blood of a pregnant woman, which are aimed at destroying the red blood cells of the child.

Symptoms in a child

At this moment, the level of bilirubin in his body increases, which negatively affects the formation and functioning of the brain. At the same time, the liver and spleen enlarge, since these organs of the child are forced to neutralize and utilize a huge number of dead cells. As a result of the destruction of red blood cells, the child suffers from oxygen starvation, which leads to death if treatment is not started in time.

Attention! The threat of Rh conflict arises only if the mother is Rh- and the father is Rh+. The probability of conflict developing is 75%. In this case, the first child of this couple is often born healthy, but it is important that the woman does not have contact with positive blood before this.

If there was a miscarriage after a Rh conflict, then Rh sensitization is possible in 3-4%; with normal childbirth, the percentage increases to 10-15.

Prevention and treatment in case of likelihood of Rh conflict

In order to timely determine the risk of developing such a reaction in the mother’s body, she is recommended to donate blood every month until the 32nd week of pregnancy. When the period varies between 32 and 35 weeks, the analysis is carried out 2 times a month. Until birth, it is advisable to donate blood every week to determine antibodies. This is the only way to protect the health of mother and child in the womb.

Treatment of a pregnant woman

Based on the level of antibodies, medical staff are able to diagnose the likelihood of a conflict developing. After labor is completed, blood is immediately taken from the baby to determine Rh. When the baby is Rh+ and the mother is Rh-, she must be given anti-Rhesus immunoglobulin in the first 72 hours after birth. This is the only way to prevent Rh conflict during the next pregnancy.

Advice! Such prevention must be carried out even if the woman had an ectopic pregnancy, had an abortion, miscarriage or placental abruption. Serum administration is required if the woman has undergone manipulation of the membranes or platelet transfusion.

It is worth starting treatment if the number of antibodies in a woman increases rapidly. The expectant mother is necessarily placed in a perinatal center, where doctors constantly monitor her and the child.

Can BG change throughout life due to pregnancy?

On various forums, women who were pregnant prove that the group is capable of changing due to their interesting situation. Allegedly, before pregnancy they had a different group. These are all just further guesses.

Taking blood from a woman

A pregnant woman's BG is not able to change. Bearing a child and giving birth in no way affects the group and Rh factor of the pregnant woman. You can find out about another group because:

Errors in previous analysis;
Development of tumors in the body (oncology);
Incorrect blood sampling.

Scientists have proven that a pregnant girl’s body produces a large number of red blood cells, but at the same time the concentration of agglutinogens drops sharply. Only in this case, during the analysis process, the expectant mother may be mistakenly diagnosed with the first BG, while in fact she has 2,3 or 4.

Can BG change due to illness during life?

The disease, whatever it is, changes the composition of the blood, but it is in no way capable of affecting the group. It’s another matter if valuable antigens are lost due to illness. Chemical processes in the blood are interconnected, so some types of diseases may affect the production of antigens and agglutinogens, but this still does not change the group.

Important! The group can be misidentified if the number of red blood cells increases sharply.

This condition can develop due to certain diseases. In addition, rare pathogenic bacteria and microbes are capable of producing enzymes that affect the composition of type A agglutinogens. Due to the pathological effects of such enzymes, type A turns into type B, which may show group 3 instead of 2. If a transfusion is done in such a situation, then an incompatibility reaction may occur.

Symptoms of Cooley's disease

There is a rare disease called Cooley's disease or thalassemia, which can reduce the production of antigens. Such a change in plasma composition may distort the analysis result. In this condition, patients are often assigned to the first group.

Oncological processes in the body can significantly affect plasma. Leukemia and hematosarcoma have a particularly pronounced effect on the number of antigens.

As a result, thinking that the Civil Code can change is a delusion. Such distortion of the results is possible only in isolated cases, but the group does not change. However, it cannot be correctly identified due to minimal production of antigens or excessive production of red blood cells.

Can BG change with transfusion?

Transfusion does not affect the BG in any way, however, there are certain exceptions to this rule:

When identifying blood to a certain group, the health worker made a mistake.
The patient suffers from a disease of the hematopoietic system (aplastic anemia), after treatment of which, his red blood cells acquire new antigenic properties that were previously suppressed by the disease.
If the patient has been transfused with a large volume of donor blood: until the “new” red blood cells die, the patient may be diagnosed with another GC for several days.
The patient underwent a donor bone marrow transplant, before which all his blood progenitor cells were destroyed using chemicals. As a result, the “new” bone marrow can produce cells with a different structure and change the BG. This probability is minimal, but it exists.

Transfusion

How do you get an incorrect test result?

BG is checked immediately after birth. A newborn child must undergo such an analysis. The standard group verification process is simple:

Capillary blood is collected;
The resulting material is transported to the laboratory;
At the third stage, the group itself is tested using reagents;
They issue a conclusion.

Even at these 4 stages, laboratory technicians are capable of making mistakes that could cost the life of the diagnosed patient in the future. In addition, the life of another person depends on the incorrectly indicated result if this patient becomes a donor.

Carrying out analysis

Most often, medical staff make a mistake when test tubes with blood are involuntarily confused. It costs nothing to swap them. Not all laboratory technicians approach the blood sampling procedure correctly and responsibly.
No one has canceled the dishonest attitude of medical staff towards the process of processing and disinfection of test tubes.
Collected materials are transported in containers so they can be mixed. Mixing of samples occurs, again, due to an unfair attitude towards work.

At this stage, the possibility of obtaining an erroneous result remains. But a greater number of medical errors occur when directly studying the analysis. This happens for the following reasons:

Incorrect addition of serum directly to the sample;
Use of expired and low-quality reagents;
Failure to comply with hygiene standards in the room where diagnostics are carried out;
Inconsistency in temperature, air humidity or lighting;
Use of outdated equipment;
Human factor, inattention, fatigue.

There is no way to protect yourself from such “diagnosis,” especially if the analysis is carried out in a public medical institution. It is better to check the group in several laboratories. It is because of negligent medical staff that most people wonder whether the RF or GK can change.

Rare causes of errors

The group cannot change - this is a fact, but the so-called subtypes of the group can distort the result of the analysis. These are quite rare features of blood that can only be diagnosed by modern methods of processing the material.

Standard Blood Test Method

Such changes occur if:

There are subtypes of type A antigen in the blood. To understand this feature, you need to know that each antigen has two types - A1 and A2. Both of these types are capable of sticking to foreign bodies in different ways, which leads to diagnostic errors in the process of diagnosing group 4. As a result, the agglutination reaction does not proceed properly, which leads to the appearance of a false group.
Uncharacteristic clumping of red blood cells. When excessive agglutination of antibodies occurs, an autoimmune process develops in the plasma. Such a reaction may affect the result of the analysis. It is for this reason that a patient may become a false owner of group 4.
Presence of erythrocyte chimeras. Doctors note such changes in the blood only in very rare cases. Often, such reactions occur in the blood of heterozygous twins who have not yet reached an early age. The appearance of erythrocyte chimeras is due to the presence of a large number of different populations of erythrocytes. When an analysis is carried out, different red blood cells may react, which leads to a false result.

Important! This factor is especially important, since during bleeding, when an urgent blood transfusion is required, the body of such a person can trigger a reaction of massive destruction of blood cells.