Glutamic acid in cardiology. Increased need for protein

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Warehouse

dyucha speech: 1 tablet of L-glutamic acid 250 mg;

additional speeches: potato starch, povidone, stearic acid, calcium stearate;

coating: tsukor, light magnesium carbonate, povidone, anhydrous silica dioxide, talc, titanium dioxide (E 171), patent blue V (E 131), yellow wax, light mineral oil.

Medicine form

Tablets, sealed with film.

Main physical and chemical properties: round tablets with a biconvex surface, covered with a black-colored coating. The cross section shows two balls. Sprinkles are allowed on the surface of the tablets.

Pharmacotherapeutic group

Know what it does to the nervous system. ATX code N07X X.

Pharmacological authorities

Pharmacodynamics.

A replacement amino acid that takes part in the processes of amino acid conversion in the body, in protein and carbohydrate metabolism, stimulates oxidation processes, absorbs excretion and excretion of ammonia from the body, feels the body's resistance to hypoxia. It promotes the synthesis of acetylcholine and ATP, the transfer of potassium ions, plays an important role in the activity of skeletal muscles. Glutamic acid is connected to neurotransmitter amino acids, which stimulate the transmission of excitement at the synapses of the central nervous system .

Pharmacokinetics.

Glutamic acid absorbs well when taken internally. The liquid is eliminated from the blood, accumulating mainly in the ulcer and nerve tissues, liver and urine, penetrates the blood-brain barrier and cell membranes. Often, glutamic acid is converted to alanine after an hour of soaking. When infused, the enzyme glutamate decarboxylase is converted in the brain into a mediator - gamma-aminobutyric acid.

About 4-7% of it is excreted unchanged and is disposed of during metabolic processes.

Showing

Treatment of epilepsy, mainly minor attacks with equivalents, somatogenic, involutional, intoxicating psychoses, reactive states with signs of depression, seizures; with delayed mental development in children, Down syndrome, with childhood cerebral palsy, polyomyelitis (acute and recent periods), with progressive myopathy, for the reduction and prevention of neurotoxic effects, They may disappear when treated with isoniazid and other drugs of the isonicotinic acid hydrazide group.

Contraindicated

Fever, increased restlessness, severe psychotic reactions, liver and/or nitric deficiency, nephrotic syndrome, virulent disease of the duodenum, disease of the hematopoietic organs, anemia, eniya.

Interactions with other medicinal drugs and other types of interactions

Together with thiamine and pyridoxine (drugs of group B vitamins), glutamic acid can be combined for the prevention and treatment of neurotoxic effects caused by patients taking drugs of the GINK group (hydrazide Isonicotinic acid, for example, ftivazide, isoniazid).

In case of myopathy and ulcerative dystrophy, glutamic acid is effective when taken with pachycarpine or glycol.

Features of stastosuvannya

During the hour of bathing, it is necessary to systematically monitor the cut and blood. If side effects occur, it is recommended to change the dosage of the drug. Glutamic acid can also be taken to relieve neurotoxic effects associated with the use of other drugs.

After taking glutamic acid, rinse your mouth with a mild solution of sodium bicarbonate.

The doctor's task is to take revenge on the tsukor, so that we may suffer from blood diabetes.

Suspension during pregnancy or breastfeeding.

This medical treatment should not be avoided during pregnancy or breastfeeding.

This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.

Physicians may infuse the drug into the nervous system, and use caution when administering the drug when using vehicles or robots with other mechanisms.

Method of congestion and dosage

As adults, take a single dose of 1 g 2-3 times per dose.

For children, single doses are given: 3-6 years of age – 250 mg, 7-9 years of age – 0.5-1 g; 10 days a week - 1 g each.

The frequency of intake is 2-3 times per dose.

For oligophrenia - 100-200 mg per 1 kg of patient body weight for several months.

Take 15-30 minutes before eating, if dyspeptic symptoms develop - before or after eating.

Treatment course – from 1-2 to 6-12 months.

Children.

Medical treatment should not be given to children under 3 years of age.

Overdose

It is possible to reduce adverse reactions.

Likuvannya: Therapy is symptomatic, rinsing the plug, stagnating with enterosorbents.

Adverse reactions

On the side of the blood and lymphatic system: decreased hemoglobin, leukopenia.

On the side of the scolio-intestinal tract: vomiting, diarrhea.

On the side of the nervous system: headache, increased fatigue, insomnia.

On the side of the immune system: allergic reactions, including dry skin, itching, hyperemia.

Term of attribution

Umovi sberіgannya

Store in original packaging at a temperature not exceeding 25 ºС.

Keep out of the reach of children.

Package

10 tablets in blisters.

10 tablets per blister, 3 blisters per pack.

Release category

Over the counter.

Virobnik

JSC "KYIV VITAMIN PLANT".

Location of the distributor and addresses of the location of its activities

04073, Ukraine, m. Kiev, st. Kopylivska, 38.

Website: www.vitamin.com.ua.

INSTRUCTIONS

By medical use medicine

GLUTAMIC ACID

(GLUTAMIC ACID)

Compound

active ingredient: 1 tablet contains L-glutamic acid 250 mg;

excipients: potato starch, povidone, stearic acid, calcium stearate;

shell: sugar, light magnesium carbonate, povidone, anhydrous colloidal silicon dioxide, talc, titanium dioxide (E 171), proprietary blue V dye (E 131), yellow wax, light mineral oil.

Dosage form. Film-coated tablets.

Basic physical and chemical properties: pills round shape with a biconvex surface, covered with a shell blue color. The cross section shows two layers. Blotches are allowed on the surface of the tablets.

Pharmacotherapeutic group. Drugs acting on the nervous system.

ATX code N07X X.

Pharmacological properties

Pharmacodynamics.

A non-essential amino acid that participates in the processes of transamination of amino acids in the body, in protein and carbohydrate metabolism, stimulates oxidative processes, promotes the neutralization and removal of ammonia from the body, increases the body's resistance to hypoxia. Promotes the synthesis of acetylcholine and ATP, the transfer of potassium ions, plays important role in the activity of skeletal muscles. Glutamic acid belongs to the neurotransmitter amino acids that stimulate the transmission of excitation in the synapses of the central nervous system.

Pharmacokinetics.

Glutamic acid is well absorbed when taken orally. It is quickly eliminated from the blood, accumulating mainly in muscle and nervous tissues, in the liver and kidneys, penetrates the blood-brain barrier and cell membranes. Partially glutamic acid during absorption it is transaminated to form alanine. Under the influence of the enzyme glutamate decarboxylase, it is converted in the brain into a mediator - gamma-aminobutyric acid.

About 4-7% of it is excreted unchanged in the urine, the rest is utilized in the process of metabolic transformations.

Clinical characteristics.

Indications

Treatment of epilepsy, mainly minor seizures with equivalents, somatogenic, involutional, intoxication psychoses, reactive states with symptoms of depression, exhaustion; when delayed mental development in children, Down's disease, cerebral palsy, polio (acute and recovery periods), with progressive myopathy, to eliminate and prevent neurotoxic phenomena that may occur when using isoniazid and other drugs of the isonicotinic acid hydrazide group.

Contraindications

Feverish states, increased excitability, pronounced psychotic reactions, hepatic and/or renal failure, nephrotic syndrome, peptic ulcer stomach and duodenum, diseases of the hematopoietic organs, anemia, leukopenia.

Interaction with other drugs and other types of interactions.

Together with thiamine and pyridoxine (preparations of B vitamins), glutamic acid can be used for the prevention and treatment of neurotoxic effects caused by patient consumption medicines GINK groups (isonicotinic acid hydrazide, for example, ftivazide, isoniazid).

For myopathy and muscular dystrophy Glutamic acid is effective in combination with pachycarpine or glycol.

Features of application

During treatment, it is necessary to systematically conduct urine and blood tests. Whenever side effects it is recommended to reduce the dose of the drug.

Glutamic acid can also be used to relieve neurotoxic effects associated with taking other drugs.

After taking Glutamic acid, you should rinse your mouth weak solution sodium bicarbonate.

The medicine contains sugar, which must be taken into account by patients with diabetes.

Use during pregnancy or breastfeeding.

This medicine should not be used during pregnancy or breastfeeding.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

Considering possible impact drug on the nervous system, the drug should be used with caution when driving vehicles or operating other mechanisms.

Directions for use and doses

For adults, prescribe a single dose of 1 g 2-3 times a day.

For children single doses are: 3-6 years – 250 mg, 7-9 years – 0.5-1 g; from 10 years – 1 year

The frequency of administration is 2-3 times a day.

For oligophrenia - 100-200 mg per 1 kg of the patient’s body weight for several months.

Take 15-30 minutes before meals, if dyspeptic symptoms develop - during or after meals.

The course of treatment is from 1-2 to 6-12 months.

Children.

The medicine should not be used in children under 3 years of age.

Overdose

Possible increased manifestations of adverse reactions.

Treatment: symptomatic therapy, gastric lavage, use of enterosorbents.

Adverse reactions

From the side of blood and lymphatic system: decreased hemoglobin content, leukopenia. From the outside gastrointestinal tract: vomiting, diarrhea.

From the nervous system: headache, increased irritability, insomnia. From the outside immune system: allergic reactions, including rash, itching, hyperemia.

Best before date

Storage conditions

Store in original packaging at a temperature not higher than 25 ºС.

Keep out of the reach of children.

Package

10 tablets in blisters.

10 tablets per blister, 3 blisters per pack.

Manufacturer

JSC "KYIV VITAMIN PLANT".

The location of the manufacturer and the address of the place of its activities.

04073, Ukraine, Kyiv, st. Kopylovskaya, 38.

Website: www.vitamin.com.ua.

Amino acids.

Composition: Glutamic acid

Active ingredient: Glutamic acid.

Manufacturers

Tatkhimpharmpreparaty (Russia)

Pharmacological action

Neurotransmitter, stimulating metabolism in the central nervous system.

Participates in protein and carbohydrate metabolism, stimulates oxidative processes, prevents a decrease in redox potential, increases the body's resistance to hypoxia.

Normalizes metabolism by changing functional state nervous and endocrine systems.

It is a neurotransmitter amino acid that stimulates the transmission of excitation in the synapses of the central nervous system.

Participates in the synthesis of other amino acids, acetylcholine, ATP, promotes the transfer of potassium ions, improves the activity of skeletal muscles (it is one of the components of myofibrils).

It has a detoxification effect, promotes the neutralization and removal of ammonia from the body.

Normalizes the processes of glycolysis in tissues, has a hepatoprotective effect, and inhibits the secretory function of the stomach.

When taken orally, it is well absorbed, penetrates the BBB and cell membranes.

Side effects Glutamic acid

Increased excitability, insomnia, abdominal pain, nausea, vomiting, diarrhea, allergic reactions, chills, short-term hyperthermia; at long-term use- anemia, leukopenia, irritation of the oral mucosa, cracked lips.

Indications for use

Epilepsy (mainly minor seizures with equivalents), schizophrenia, psychoses (somatogenic, intoxication, involutional), reactive states occurring with symptoms of exhaustion, depression, consequences of meningitis and encephalitis, toxic neuropathy due to the use of isonicotinic acid hydrazides (in combination with thiamine and pyridoxine ), hepatic coma.

In pediatrics - mental retardation, cerebral palsy, consequences of intracranial birth trauma, Down's disease, polio (acute and recovery periods).

Contraindications Glutamic acid

Hypersensitivity, fever, liver and/or renal failure, nephrotic syndrome, gastric and duodenal ulcers, diseases hematopoietic organs, anemia, leukopenia, increased excitability, violent mental reactions, obesity.

Restrictions on use.

Kidney and liver diseases.

Directions for use and dosage

Inside, 15-30 minutes before meals.

Adults and children 10 years and older - 1 g 2-3 times a day.

For children:

• up to 1 year - 0.1 g, 1-3 years - 0.15 g, 3-4 years - 0.25 g, 5-6 years - 0.4 g, 7-9 years - 0 .5-1 g, 2-3 times a day;
• for oligophrenia - 0.1-0.2 g/kg.

The course of treatment is from 1-2 to 6-12 months.

Overdose

No data available.

Interaction

The effectiveness of use in combination with pachycarpine or glycine has been shown for progressive myopathy.

Special instructions

During the treatment period, regular general clinical blood and urine tests are necessary.

If side effects occur, stop taking and consult a doctor.

After oral administration in powder or suspension form, it is recommended to rinse the mouth with a weak solution of sodium bicarbonate.

If symptoms of dyspepsia develop, take during or after meals.

Glutamic acid is a popular amino acid essential for muscle growth and immune support. It can be purchased at any sports store. Makes up a quarter of all amino acids in the body. It is added to proteins.

This demand for the substance can be explained by the fact that it is inexpensive and has beneficial properties. Let's look at the instructions for using glutamic acid, as well as its beneficial properties.

Differences from glutamine

Glutamic acid is one of the many main components of all tissues, but the brain contains it most of all; its role is very important. If glutamate is introduced into the cerebral cortex, a powerful excitation reaction follows.

In medicine, it has a psychostimulating and nootropic effect, helping with a number of diseases of the nervous system. It is worth considering that glutamine and glutamic acid - different substances. The first is a restorative acid, the second is a stimulating acid. The acid is a precursor to glutamine. Muscles need glutamine.

Glutamic acid is an amino acid that has a nootropic effect and is necessary for the central nervous system. The brain uses it as a source of energy.

It is prescribed if it is necessary to correct behavioral disorders in children, for the treatment of epilepsy, muscular dystrophy, and so on. Glutamine production occurs in the brain. It neutralizes ammonia, there is a lot of it in muscles, improves brain activity. Cannot be stored in a damp place.

Glutamine is involved in the synthesis of other amino acids and performs many functions in the body, so it is worth consuming appropriate supplements. The lion's share of amino acids in muscles comes from glutamine. Protects against liver and kidney poisoning, suppresses the effect of some drugs and activates the effect of others.

If the body's supply of glutamine is large, muscles regenerate faster after strength training and other activities. Most glutamic acid is found in foods: milk, Parmesan, then peas and duck meat.

Glutamic acid is replaceable, the body is able to independently provide its synthesis. A person can cover the need for this substance with the help regular products nutrition, but the athlete needs it in large quantities.

Glutamine helps produce growth hormone, retains nitrogen in the body, and delivers it to enzymes. With a negative nitrogen balance, aging begins. Helps potassium penetrate deeper into muscle fibers.

Glutamine neutralizes ammonia, which destroys muscle cells. Growth hormone supports fat metabolism and muscle tissue growth. It becomes glucose in the liver, helping glycogen accumulate.

Actions of glutamine:

• Energy source;
• Suppresses the secretion of cortisol;
• Strengthens immune forces;
• Allows the body to recover faster after training.

During training, the need for glutamic acid increases. It stops the destruction of proteins.

Dosage form

L-glutamic acid is available in tablets. The drug activates the redox processes of the brain, affects protein metabolism, and also:

1. Normalizes metabolism;
2. Neutralizes and removes ammonia;
3. The body becomes more resistant to hypoxia;
4. Has a good effect on the nervous system;
5. Supports required quantity potassium ions in the brain;
6. Reduces the secretion of gastric juice.

It is prescribed in a complex of many diseases associated with damage to the nervous system. Helps with epilepsy, schizophrenia, restless sleep and so on.

Dosage

Taking glutamic acid twice a day will provide the body with sufficient quantity substances: morning, afternoon. If your schedule is to visit the gym, then after fitness. Girls can take 5 g, men - 10 g. The substance is diluted with water, if in powder, or added to protein shakes.

They also take pills. If you take glutamine during the season colds, the risk of getting sick will decrease.

Receipt

Thanks to the salt of glutamic acid, monosodium glutamate, the tastes of products are enhanced, they are stored longer and do not lose their taste. Widely used in the canning industry. The substance can stimulate the function of the digestive glands.

Glutamic acid is obtained by hydrolysis of proteins. This classic way obtaining amino acids. Milk casein is used to obtain corn gluten, waste from meat processing plants and other proteins. This is an expensive method, since the acid must be carefully purified.

Another method of production is microbiological synthesis. Some yeasts and bacteria are capable of secreting this substance. But the method of production using bacteria is more valuable.

The production scheme for glutamic acid is similar to the production scheme for lysine, an essential acid.

They differ in the properties of the microorganism, the composition of the environment and other indicators. This is also an essential amino acid and is involved in the formation of collagen fibers and tissue regeneration. Needed for correct formation bones, helps absorb calcium.

Analogues and synonyms

Along with glutamic acid, aspartic acid redistributes nitrogen in the body and neutralizes ammonia.

An analogue of glutamic acid is Epilapton. Also improves brain metabolism. Like glutamic acid, it affects protein metabolism and changes the functional state of the central nervous system.

Based on L-glutamic acid with glycine and L-cystine, the drug Eltacin was created, which increases the body’s resistance to physical activity, improving the quality of life of patients with heart disease.

In some cases it is replaced:

1. Glycine, which improves brain activity. It is prescribed for depression and nervous disorders. Glycine is designed to increase mental performance person;
2. Cortexin also has a nootropic effect. The cost is about 800 rubles. Improves concentration, learning process, strengthens memory;
3. Cytoflavin is also a nootropic that improves metabolism.

In sports

Participates in the synthesis of many different amino acids. Glutamic acid in sports is important and applicable for muscle growth and its preservation. Able to retain moisture in cells, forming a beautiful, sculpted body. The production of growth hormone increases, performance improves. Strengthens the immune system, which is important for athletes, since any illness will deprive you of the opportunity to train for about a month.

In bodybuilding they know that the faster the metabolism goes, the sooner you can drive the body to the coveted standard of professional form, and the above-mentioned acid is a direct participant different types exchange. From it is formed aminobutyric acid, which improves blood supply to the brain.

If an athlete decides to dry out and not lose muscle mass, the dosage should be different. You need to follow a low carbohydrate diet. Muscle catabolism is not a problem if you take 30 g of glutamine per day. If there is a lack of carbohydrates, the body will suck amino acids from the muscles, then it is impossible to strengthen them.

Daily intake in similar dosages strengthens the immune system.

Prices for glutamic acid in pharmacies can reach up to 200 rubles.

Formula: C5H9NO4, chemical name: L-Glutamic acid.
Pharmacological group: neurotropic drugs/nootropics;
Metabolics/Proteins and Amino Acids/Essential Amino Acids; means for parenteral and enteral nutrition; detoxifying agents, including antidotes.
Pharmacological action: stimulating metabolism in the central nervous system, neurotransmitter.

Pharmacological properties

Glutamic acid is a non-essential amino acid that can enter the body with food, and can also be synthesized in the body during protein catabolism during transamination. Participates in carbohydrate and protein metabolism, prevents a decrease in redox potentials, stimulates oxidation processes, and increases the body's stability during hypoxia. Glutamic acid normalizes metabolism by changing the functional state of the endocrine and nervous systems. It is also a neurotransmitter amino acid that stimulates the transmission of excitation in the synapses of the central nervous system. Participates in the formation of other amino acids, ATP, acetylcholine, helps in the transfer of potassium ions, improves performance skeletal muscle(is one of the components of myofibrils). Glutamic acid has a detoxifying property, promotes the removal and neutralization of ammonia in the body. Improves glycolysis processes in tissues, reduces secretion in the stomach, and has a hepatoprotective effect. When used orally, it is well absorbed and penetrates cell membranes and the blood-brain barrier. It is utilized during metabolism and 4–7% is excreted unchanged by the kidneys. Efficiency achieved sharing with glycine or pachycarpine for progressive myopathy.

Indications

Epilepsy (especially with petit mal seizures with equivalents); psychoses (intoxication, somatogenic, involutional); schizophrenia; reactive states that occur with symptoms of exhaustion; consequences of encephalitis and meningitis; depression; hepatic coma; toxic neuropathy when taking isonicotinic acid hydrazides (together with pyridoxine and thiamine); in pediatrics for mental retardation, cerebral palsy, consequences of childbirth intracranial injury, Down's disease, polio (recovery and acute periods).

Method of use of glutamic acid and dose

Glutamic acid is taken orally 15–30 minutes before meals. Children over 10 years old and adults 2 – 3 times a day, 1 g; for children: ; 7–9 years - 0.5–1 g, 2–3 times a day; 5–6 years - 0.4 g; 3–4 years - 0.25 g; 1–3 years - 0.15 g; up to 1 year - 0.1 g; for oligophrenia - 0.1–0.2 g/kg. Duration of therapy is from 1–2 to 6–12 months.
If you miss the next dose of glutamic acid, take it as you remember, then take glutamic acid after prescribed by a doctor from time to time last used. After ingestion in the form of a suspension or powder, it is recommended to rinse the mouth with a weak solution of sodium bicarbonate. If dyspepsia occurs, it should be taken after or during meals. During therapy with glutamic acid, regular general clinical urine and blood tests are necessary. During development side effects it is necessary to stop taking the drug and consult a doctor.

Contraindications for use

Hypersensitivity, renal or liver failure, fever, nephrotic syndrome, diseases of the hematopoietic organs, peptic ulcer, leukopenia, anemia, increased excitability, obesity, rapidly occurring psychotic reactions.

Restrictions on use

Liver and kidney diseases.

Use during pregnancy and breastfeeding

You can use glutamic acid, but only if prescribed by a doctor.

Side effects of glutamic acid

Increased excitability, abdominal pain, insomnia, vomiting, diarrhea, nausea, allergic reactions, short-term hyperthermia, chills; with prolonged use - leukopenia, anemia, cracked lips, irritation of the oral mucosa.

Interaction of glutamic acid with other substances

Together with pyridoxine and thiamine, they are used for the treatment and prevention of neurotoxic phenomena that are caused by drugs from the isonicotinic acid hydrazide group (ftivazide, isoniazid and others). For muscular dystrophy and myopathy, glutamic acid is more effective when used in conjunction with glycocol and pachycarpine.

Gross formula

C5H9NO4

Pharmacological group of the substance Glutamic acid

Nosological classification (ICD-10)

CAS code

6899-05-4

Characteristics of the substance Glutamic acid

White crystalline powder sour taste. Slightly soluble in cold water, soluble in hot water(pH aqueous solution 3.4-3.6), practically insoluble in alcohol.

Pharmacology

Pharmacological action- neurotransmitter, stimulating metabolism in the central nervous system.

A non-essential amino acid, it enters the body with food and is also synthesized in the body during transamination during protein catabolism. Participates in protein and carbohydrate metabolism, stimulates oxidative processes, prevents a decrease in redox potential, and increases the body's resistance to hypoxia. Normalizes metabolism, changing the functional state of the nervous and endocrine systems.

It is a neurotransmitter amino acid that stimulates the transmission of excitation in the synapses of the central nervous system. Participates in the synthesis of other amino acids, acetylcholine, ATP, promotes the transfer of potassium ions, improves the activity of skeletal muscles (it is one of the components of myofibrils). It has a detoxification effect, promotes the neutralization and removal of ammonia from the body. Normalizes the processes of glycolysis in tissues, has a hepatoprotective effect, and inhibits the secretory function of the stomach.

When taken orally, it is well absorbed and penetrates the BBB and cell membranes. It is utilized during metabolism, 4-7% is excreted unchanged by the kidneys.

The effectiveness of combined use with pachycarpine or glycine for progressive myopathy has been shown.

Application of the substance Glutamic acid

Epilepsy (mainly minor seizures with equivalents), schizophrenia, psychoses (somatogenic, intoxication, involutional), reactive states occurring with symptoms of exhaustion, depression, consequences of meningitis and encephalitis, toxic neuropathy due to the use of isonicotinic acid hydrazides (in combination with thiamine and pyridoxine ), hepatic coma. In pediatrics - mental retardation, cerebral palsy, consequences of intracranial birth injury, Down's disease, poliomyelitis (acute and recovery periods).

Contraindications

Hypersensitivity, fever, liver and/or renal failure, nephrotic syndrome, peptic ulcer of the stomach and duodenum, diseases of the hematopoietic organs, anemia, leukopenia, increased excitability, rapidly occurring psychotic reactions, obesity.

Restrictions on use

Kidney and liver diseases.

Side effects of the substance Glutamic acid

Increased excitability, insomnia, abdominal pain, nausea, vomiting, diarrhea, allergic reactions, chills, short-term hyperthermia; with long-term use - anemia, leukopenia, irritation of the oral mucosa, cracks on the lips.

Precautions for the substance Glutamic acid

During the treatment period, regular general clinical blood and urine tests are necessary. If side effects occur, stop taking and consult a doctor.