"Solpadeine" is an effective medicine for pain. Solpadeine soluble tablets - instructions for use How to drink solpadeine soluble

Solpadeine - what kind of drug? Possible applications for various diseases; dosages and actions in children and adults. Contraindications and side effects. What does it contain; information about the most popular forms of the product.

Paracetamol reduces temperature and has an analgesic effect. Caffeine tones - it neutralizes drowsiness and fatigue; improves mental and physical activity, increases blood pressure during hypotension. In addition, its effect enhances the analgesic effect of paracetamol. Codeine also relieves pain and improves pain-relieving effects.

Application of Solpadeine

The doctor can recommend Solpadein to patients - adolescents over 12 years of age and adults, for various pains: neuralgia, toothache, sore throat, sinusitis, migraines and headaches, muscle pain, joint pain, injuries and radiculitis, menstrual pain. The medicine also works against infectious and inflammatory diseases, including colds and flu.

Dosage for children

Solpadeine is taken orally after meals. Tablets/capsules are swallowed whole with water, while effervescent tablets are pre-dissolved, one tablet in half a glass of water.

Adolescents over 16 years of age can take 1-2 tablets or two capsules three or four times a day with a minimum interval of 4 hours. a single dose can be no more than two tablets or capsules, and the maximum daily dose is 8.

Children 12-16 years old most often take one tablet or capsule 3-4 times a day. Maximum daily consumption is 4 tablets or capsules.

Children, adolescents and adults who are treated with Solpadeine cannot have their doses adjusted accidentally. It is correct and safe to take the drug to reduce fever for no more than three days and as an analgesic for up to five.

Dosage for adults

Solpadeine reduces fever and pain.

The dose for adults is the same as for adolescents over 16 years of age. That is, taking traditional tablets or capsules is 1-2 times to 4 times a day after meals. Daily dose - up to 8 pcs.

For neuralgia

Neuralgia is a painful condition. The pain can be constant and throbbing, or intermittent. He may suddenly stop and appear again. Such conditions can last for weeks or even months. Sometimes, in addition to pain in the area of the problem, you can see redness and swelling, the skin may lose sensitivity - but this always happens in a limited area where the affected nerve is located. The cause of discomfort is most often cold combined with prolonged and heavy physical exertion. This leads to microtrauma of the nerve root. Nerve fibers can also be affected by toxins, heavy metals, alcohol abuse and so on, inflammatory diseases of the musculoskeletal system.

Factors that cause unpleasant conditions also include diseases such as diabetes, tumors, peripheral vascular diseases, atherosclerosis - all of them have a negative effect on the blood supply to nervous tissue. Taking Solpadeine in such cases is justified from the point of view of bad or moderate pain. The medicine is taken in the doses indicated above. With a prescription, it is possible to extend the administration of prodapidine soluble tablets for 10 days.

Against toothache

It can be immediately confirmed that Solpadeine is one of the possible drugs to treat the symptoms of toothache. Paracetamol plays an active role in these cases. The drug is suitable for cases of mild to moderate pain; Well-known products such as analgin, aspirin, and panadol are used in a similar way. However, even in case of suffering such as dental pain, the above daily doses should not be exceeded. We mentioned that the drug is taken as an analgesic for no more than five days. But is it wise to suppress a toothache for five days and then suffer again? It is normal to take a tablet or capsule to relieve the pain until we can get to the dentist. Typically, a toothache is a signal that we really need to visit.

After tooth extraction

It is not always necessary to provide analgesia after tooth extraction; in many cases the residual effect of local anesthesia is sufficient and discomfort is tolerable once it subsides. However, when removing a tooth, it is good to have Solpadeine tablets or capsules ready. This treatment is considered appropriate in cases of moderate to severe pain. If it worsens, it is better to switch to liquid analgin.

At high temperature

As we have already mentioned, the temperature-lowering effect is due to the paracetamol component. We should not forget that the drug is taken at intervals of at least 4 hours. It cannot be shortened to cause a faster temperature drop. If two or three consecutive doses do not help, you may need to rethink your therapy. As a rule, Solpadeine is taken to reduce fever for no more than three days.

In case of runny nose and colds

The effect of soluble tablets is considered the fastest. Typically, cold water is chosen for effervescent tablets. Taking them in this form helps them act faster. The effect is complex - a decrease in temperature and neutralization of all pain inherent in such conditions. Treatment lasts 3 to 5 days depending on the response. You can extend it up to 10 days, but only after consulting a doctor. The first 1-2 doses can be two tablets one after the other, each half dissolved in a glass of water. Do not use on children under 12 years of age.

Effervescent tablets are a good option for sinusitis with severe fever and symptomatic illness - such as moderate pain. Three-day therapy cannot give the expected result of using Solpadeine for pain. This may mean that the condition requires more serious medications with antibiotics.

For viral diseases

Solpadeine has a complex effect for viral diseases. The medicine, whatever the preferred form, works to control the symptoms of the disease. In addition to the fever-reducing and pain-relieving effects - think about joints and sore throat when swallowed; Thanks to its active ingredients, the drug can mobilize resistance forces after the acute phase of the disease has passed.

For rheumatism

Solpadeine helps with moderate rheumatic pain, usually during a short period of exacerbation. Its complex effect relieves symptoms such as persistent pain, joint pain with or without swelling, fever, feeling tired from heart disease. Of course, the product is quite favorable - a limited period of participation in complex therapy; Antibiotics and corticosteroids remain the usual treatment in such cases.

For sore throat (inflammation) and pharyngitis

Unpleasant sensations in the throat, including pharyngitis, are associated with the inflammatory process that occurs in this area. As we know, consumption of Solpadeine saves from pain and possible fever. However, we should know that the pain relief is due to the codeine contained in the product. It is unlikely that every user knows that codeine is from the opium group, along with morphine and heroin. Its effect is to suppress the brain centers that form and recognize the sensation of pain. That is, the drug relieves symptoms, but this does not mean that it contributes to treatment. Treatment is associated with the anti-inflammatory effect of taking paracetamol. To summarize: for sore throat, taking Solpadeine makes sense mainly to ease the tolerability of the disease.

In case of headache and migraine

We use the effect of codeine as a key to the brain's pain response mechanism. The product is good for short term use; It is no coincidence that its use is limited in time or if taken for longer, it should be done under the supervision of a doctor.

Hungover

Experts on the subject believe that the only cure for a hangover is time. However, this does not mean that we should passively wait for everything to pass. We need to keep headaches at bay first and foremost, and Solpadeine does a good job in this regard. Ideally, basic type dissolvable tablets containing codeine are already mentioned. Paracetamol in a tablet that we drink, dissolved in a glass of water, helps restore the disturbed water balance in the body - it increases symptomatic thirst, and we rush to get rid of fluid from the body. Solpadeine tablets are the most suitable choice.

Muscle pain, sciatica

All muscle and joint pain, back pain, sore throat can be controlled short-term with the help of Solpadeine. These conditions require accurate diagnosis and complex treatment with drugs selected depending on the type of disease. Taking Solpadeine helps manage pain conditions and poor motor skills; short-term use in the doses indicated above. Naturally, the product acts as quickly as soluble tablets.

For menstrual pain

Solpadeine is one of the drugs recommended as a remedy for menstrual pain. The product ingredients work as described above. Reviews on forums are not always indicative, but in search of relief, it does not prevent you from trying the indicated doses and timing.

Composition of Solpadeine and the effect of ingredients

One tablet - soluble or standard - contains 500 mg of paracetamol, 30 mg of caffeine and 8 mg of codeine. This is the content of three active ingredients in capsules. Paracetamol is present in the highest dose and is mainly due to its analgesic and temperature-reducing effects. Codeine transforms the perception of pain and suppresses the cough reflex - for throat problems and coughing. Caffeine enhances the analgesic effect of paracetamol and codeine, which stimulate and mobilize the central nervous system. It improves the absorption of the product as a whole and increases the concentration of paracetamol and codeine in the brain. Neutralises the tendency to depression caused by sensations of pain.

Paracetamol

Paracetamol is quickly and almost completely digested in the gastrointestinal tract. Within 15-60 minutes it reaches its maximum concentration in the blood plasma and is effective for four hours. Relatively evenly distributed in the body, about 30% of the component is associated with plasma proteins. Metabolites are excreted from the body in urine within 24 hours. Decomposition processes occur in the liver, which at high doses or long-term use can cause a hepatotoxic effect. This is one of the reasons that the label for Solpadeine should include a warning for limited use and compliance with acceptable daily doses.

Codeine

Another warning against overdose relates to the codeine component from which some Solpadeine products are made. Codeine is also digested in the gastrointestinal tract within a short time. Then its biotransformation proceeds to the breakdown of metabolites of morphine and norecodeine. Products from metabolic degradation are excreted in the urine. For codeine, the condition is not to use drugs with such an ingredient for a long time due to the addictive effects. Successful pain relief causes some to stick around early, but it requires higher doses to achieve the desired effect.

Caffeine

We know about caffeine that it has a tonic effect, reduces drowsiness and fatigue. If the patient has problems with low blood pressure and slow pulse, Solpadeine will provide support in this direction. However, if a hypertensive patient is treated with Solpadeine, the person should be warned about a possible increase in blood pressure, i.e. in this group of patients, an overdose is unacceptable under any circumstances. Typically, the ingredient supports the exhausted body, increases its endurance and supports the therapeutic effects of the other two ingredients.

Contraindications and side effects

Although it is free and available without a prescription at local pharmacies, Solpadeine has contraindications and its treatment limitations should not be forgotten. In some cases, it should not be used:

with organic diseases of the cardiovascular system (atherosclerosis, acute myocardial infarction);
with arterial hypertension;
for neutropenia;
agranulocytosis;
heart rhythm disturbances of various types;
anemia;
bronchial asthma;
respiratory failure;
increased intracranial pressure;
anxiety disorders;
sleep disorders;
renal failure;
severe alcohol intoxication.

The medicine is not used to treat children under 12 years of age, pregnant women and nursing mothers. Due to the content of paracetamol and codeine, Solpadeine cannot be combined with other medicines that contain them.

In some cases, short-term administration of the minimum effective dose is allowed under medical supervision, for example, when:

viral hepatitis,
glaucoma,
intestinal dysfunction,
kidney and liver diseases,
with increased excitability and tendency to convulsions,
for some blood diseases.

After evaluation of possible side effects and changes in intensity, it can be taken in combination with antiemetics, tricyclic antidepressants, sedatives or hypnotics in the elderly.

When can Solpadeine be harmful?

When Solpadeine is taken in recommended doses, the drug is usually well tolerated. Allergic reactions such as rash, urticaria, bronchospasm or swelling are possible. A negative effect is possible if the restrictions of these contraindications are violated. Overdose or long-term consumption can be especially dangerous for the liver, which is involved in metabolic breakdown. The toxic effect of salt overload can cause hepatitis and even more serious effects on this important organ. Another danger comes from using codeine under the same conditions; in this case, the need for constant use and higher doses of the product to which the patient develops dependence adds to the overload of liver metabolism.

During pregnancy and lactation

The general rule is that Solpadeine should not be used during pregnancy and lactation. At the same time, the annotations allow the nurse to take the medicine, but only if it is authorized by the doctor, for a short time and in minimal doses. The problem is that small amounts of the active ingredients pass into the milk and can have a negative effect on the baby. Codeine in higher doses also causes morphine toxicity. It is expressed in excessive child drowsiness, weakened sucking reflex, and difficulty breathing. With a certain rate of metabolism of codeine in the mother's body, the effect can be fatal.

High doses of Solpadeine can enhance the stimulating effect of caffeine and cause excessive stimulation and tension in the cardiovascular system.

Maximum reception time

Standard delivery times are three days for pain relief and 5 days for fever. Some sources indicate consumption within 5-7-10 days on the recommendation of a doctor, but this does not mean automatically accepting such a period for a universal one.

Overdose, dangers, side effects

Overdose leads to negative consequences and requires medical attention to control them. Symptoms of overdose are:

nausea and vomiting,
stomach pain,
facial pallor,
appetite suppression and refusal to eat,
insomnia,
heart rhythm disturbance,
tachycardia.

If higher doses of the drug are systemic, signs of liver abnormalities appear on the second day - yellowing of the skin, upper right abdominal pain, fatigue. Abnormal liver damage may develop with liver failure, and the patient may even end up in a coma.

What happens when you overdose on Solpadeine? If possible, even before doctors arrive - if possible - induce vomiting. Gastric lavage is the first thing the doctor will order you to do in the hospital. The patient should begin drinking water in small sips at short intervals, taking two liters of liquid. Activated carbon is also useful. The hospital will decide what therapeutic measures are necessary to restore normal liver, breathing and cardiac function.

In order not to experience such conditions, it is necessary to follow some rules for treatment with Solpadeine. For example, excessive use of strong tea and coffee is not recommended due to the doses of codeine and caffeine in the drug. There is a risk of increasing the stimulating effect, and thus conditions with insomnia, agitation and anxiety arise.

During long-term treatment, which is only acceptable under medical supervision, the peripheral blood supply is systematically monitored. The ban on alcohol is permanent. We also mentioned the risk of addiction as the pain-relieving effect of the product decreases over time. It has also been associated with possible allergic reactions - so careful monitoring for abnormal rashes and breathing problems should be observed. Establishing them means immediately stopping use and contacting your doctor.

The use of Solpadeine may affect the concentration and accuracy of reactions, so it is best to avoid driving or operating heavy machinery while using it.

Interaction with other drugs

The concomitant use of Solpadeine with rifampicin, salicylates, barbiturates and antiepileptic drugs causes toxic metabolites of paracetamol, which adversely affect the liver.

Concomitant use with ethanol increases the risk of hepatotoxic effects - for this reason, the prohibition of alcohol in Solpadeine therapy is emphasized. If Solpadeine is taken simultaneously with metoclopramide, it accelerates the absorption of paracetamol. Combination with ergotamine increases the absorption of ergotamine. There is a risk of bleeding in combination with anticoagulants. At higher doses, the composition of the drug affects the central nervous system.

Reviews from forums

The forums also note the role of Solpadeine - mainly as an analgesic. Users have reservations about the drug, mainly due to its very active advertising in the media. In the end, it turns out that it does work, and cases of treating toothache and neuralgia are reported.

The fears some caffeine and codeine users have about the pills are unfounded, according to other people who have experienced the effects. Since the amount of these two components is small, an overdose is dangerous not because of them, but because of the more active paracetamol.

Some of the comments on the forums concerned combinations with other drugs. We already know that the product has a fairly wide range of interactions; It is necessary to consult with a doctor; it is unlikely that a forum - even a specialized one - is a good solution in this case.

Women on women's forums admit they haven't gotten the relief they expect from painful periods.

Types of Solpadeine, pros and cons, price

The products sold in our market are dissolvable tablets and Solpadeine Fast. The preferred option is effervescent tablets with paracetamol, caffeine and codeine due to the rapid pain-relieving effect and because the effect is more pronounced in the presence of the codeine component.

We have already mentioned that the medicine is taken after meals; Each tablet is dissolved in half a glass of water immediately before use. We remind you that the dose for adults and adolescents over 16 years of age is 1-2 tablets up to 4 times a day. An interval of at least 4 hours is maintained between individual doses. The maximum dose for this group is 8 tablets over 24 hours. Children aged 12 to 16 years have a “ceiling” of 4 tablets, up to 4 times one tablet. At elevated temperatures, it is taken for up to three days and as an analgesic for up to 5. Corrections are possible, but only by the attending physician. The price of this product starts from 80 rubles for a package of 12 effervescent tablets.

Solpadeine Fast, soluble, is considered lighter: the content of one tablet is 500 mg of paracetamol and 65 g of caffeine. There is no codeine, which allows for wider use in certain risk groups such as pregnant women and nursing mothers. Naturally - under a medical certificate and under control. Reception for children over 12 years of age and adults is 1-2 tablets within 4 hours, but not more than 8 within 24 hours. Before taking each tablet, dissolve approximately 100 ml of water. Take after meals; The same restrictions on the duration of the course apply as in the case of codeine tablets.

Each capsule of Solpadeine contains 500 mg of paracetamol, 8 mg of codeine and 30 mg of caffeine. The rules for administering the product are the same as for effervescent tablets. The price of a package of 12 capsules is about 95 rubles.

There is no information about Solpadeine powder on the domestic pharmaceutical market.

Alternatives to Solpadeine

Solpadeine is not the only drug to combat mild to moderate pain. The drug market offers many options, but the best one for us depends on the specific health problem. Most consumers are not knowledgeable in this area, and the smartest thing to do is to leave the choice to the physician.

Aulin powder

Aulin is a non-steroidal anti-inflammatory drug - it can be bought without a prescription, it is available in powder or in soluble tablets. Take with water once or twice daily after meals. According to the annotation, the course of treatment with this medicine is limited to 15 days. However, experts generally recommend that painkillers be taken for a shorter period of time or only for severe pain. The active ingredient in ayuline is nimesulide - 100 mg per dose. This component is quite aggressive in relation to the gastrointestinal tract and respiratory system - it can cause bleeding and breathing difficulties. In addition, experts warn of an increased risk of heart attack or stroke. It is for this reason that we need to consult a doctor before treatment with Aulin, who is aware of our general health condition and possible contraindications in a particular case. The product is contraindicated during pregnancy, breastfeeding, cardiac, hepatic, renal and respiratory failure. It is not used in children under 12 years of age or in cases of fever and flu.

Paracetamol

Paracetamol is indicated for the treatment of mild to moderate pain; has an analgesic and temperature-lowering effect. It is also one of the active ingredients in Solpadeine's comments - the reasons for using paracetamol are similar to those already discussed here. It is not used for allergic reactions to the ingredients or in people with kidney or liver disease. When treating colds and flu or other conditions with fever and pain, the composition of other drugs that are taken in parallel is taken into account - many of them contain paracetamol as an active ingredient. During pregnancy, it can be taken in limited doses under medical supervision; contraindicated during the first three months. This is acceptable while breastfeeding, again only on medical advice. Paracetamol has quite a few side effects, especially when taken long term or with higher doses. Symptoms such as nausea and vomiting, sweating and general malaise for liver problems; kidneys are also at risk. The drug can be used in age-specific doses and for children over 6 years of age. It works and is safe if the user is aware of the contraindications and uses the minimum effective dose in the shortest possible time.

Panadol (soluble)

Panadol soluble tablets are essentially the “twins” of paracetamol. One Panadol effervescent tablet contains 500 mg of paracetamol. The same contraindications and side effects exist, so all warnings about the products we tested also apply to Panadol. It is important that the warning is followed by a 4-hour pause between two doses of the tablet diluted with water. The daily dose is 4 tablets for adults or two for children over 6 years of age (the breakthrough dose for the 6-12 year old group is half a tablet). Children under 6 years of age do not take this form.

Nurofen

Nurofen is a member of a group of drugs with the active ingredient ibuprofen. A standard tablet contains 200 mg of active substance. Non-steroidal anti-inflammatory drugs, which are recommended for conditions with pain, fever and swelling. It is often taken for muscle and joint pain, but also for cold and flu symptoms. The drug is contraindicated for the treatment of allergies to ibuprofen, acetylsalicylic acid or other non-steroidal anti-inflammatory drugs. It should not be used during the last three months of pregnancy, hypertension, tachycardia, children under 12 years of age, heart disease, ulcers or gastrointestinal bleeding, asthma. Take 1-2 tablets at the beginning, then one tablet every 4 hours - but no more than 6 per day. Side effects affect the functions of the gastrointestinal tract, respiratory and cardiovascular systems. Long-term consumption in high doses is not recommended due to negative effects on the kidneys and liver.

Ibuprofen

Ibuprofen is the original nonsteroidal anti-inflammatory drug that is often a component of combination powders and tablets for fever and pain. The rules for its adoption are identical to the rules recently for Nurofen. 200 mg tablets reach their full effect within one hour or two after oral administration. It is not given to children under 12 years of age; risk groups - patients with kidney and liver problems, asthma, cardiovascular problems, etc., contraindicated during the last three months of pregnancy; in the first to sixth cases it can be taken with caution under the supervision of a doctor.

Grade

Efficiency
Safety

Description

Solpadeine is an effective drug with a temperature-lowering and analgesic effect. Its ingredients are paracetamol, codeine and caffeine.

Pros

An effective remedy
Many release forms.

Cons

Cannot be taken for a long period
There are many contraindications.

N02BE71 Paracetamol in combination with psycholeptics

Pharmacological group

Anilides in combinations

Composition and release form

1 soluble tablet or capsule contains paracetamol 500 mg, codeine phosphate hemihydrate 8 mg and caffeine 30 mg; in a laminated strip 2 pcs. (solvent tablet), 6 strips in a box, or 6 and 12 pcs in a blister. (table, capsule), 1 blister in a box.

Pharmacological action

Pharmacological effects - antitussive, analgesic, antipyretic.

Inhibits PG synthesis, reduces the excitability of the heat and cough centers, and enhances heat transfer.

Pharmacodynamics

Paracetamol exhibits antipyretic and analgesic effects, selectively inhibiting the synthesis of PG in the central nervous system. Codeine, by stimulating opiate receptors in the brain, changes the nature of pain perception and suppresses cough. Caffeine enhances the analgesic properties of paracetamol and codeine due to its stimulating effect on the central nervous system, can eliminate depression associated with pain and, in addition, by increasing the permeability of histohematological barriers, will increase the concentration of the remaining components of Solpadeine in the brain.

Pharmacokinetics

Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract; plasma concentration reaches a peak value after 15-60 minutes. T1/2 in plasma - 1-4 hours. Relatively evenly distributed in the body, 20-30% bound to plasma proteins. Excreted in the urine in the form of metabolites (when taking a therapeutic dosage, 100% is excreted in the urine within 24 hours). Codeine phosphate is normally absorbed from the gastrointestinal tract and is biotransformed in the liver to metabolites (morphine, norcodeine, etc.). It is excreted from the body in the urine, mainly in the form of compounds with glucuronic acid. T1/2 in plasma - 3-4 hours. Caffeine is quickly absorbed, Cmax is reached in 20-60 minutes, T1/2 - about 4 hours. Within 48 hours, about 45% is excreted in the urine in the form of 1-methylurea acid and 1-methylxanthine .

Indications for the drug Solpadeine

Pain syndrome (headache, rheumatic pain, toothache, migraine, menalgia, neuralgia, lumbago, traumatic pain, sprain pain), sinusitis, fever, colds and flu (symptomatic treatment).

Contraindications

Hypersensitivity, acute attacks of bronchial asthma, respiratory failure, head injuries, increased intracranial pressure, conditions after operations on the biliary tract.

Use during pregnancy and breastfeeding

Contraindicated during pregnancy. During breastfeeding it is permissible, but after consultation with a doctor.

Side effects

Nausea, vomiting, dizziness, insomnia, nervous agitation, constipation, allergic reactions (skin rashes).

Interaction

Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol.

Directions for use and doses

Orally (up to 4 times a day with a minimum interval between doses of 4 hours) adults 2 tables each (caps.) up to 4 times a day (the highest daily dosage is 8 tablets (caps.)), children from 7 to 12 years old- 1/2-1 table. (the highest daily dosage is 4 tablets). Soluble tablets are initially dissolved in a glass of water.

Overdose

Complications from overdose are most likely in patients with non-cirrhotic liver damage. Symptoms - pallor, nausea, vomiting, anorexia, abdominal pain, signs of circulatory and respiratory depression, tremor, nervousness, irritability. Treatment - for an overdose of paracetamol - taking meglonine orally or intravenously administering N-acetylcysteine; in case of caffeine overdose - gastric lavage, in severe cases - artificial ventilation, use of oxygen and naloxone.

Precautions

It should not be used together with other paracetamol-containing products, or given to children under 12 years of age in capsules, tablets, and under 7 years of age - soluble tablets. It is not recommended to violate the dosage regimen - no more than 4 doses in 24 hours. Take with caution in case of acute kidney diseases and liver diseases in combination with MAO inhibitors, against the background of alcohol. Excessive consumption of coffee and tea can cause tension and irritability.

Storage conditions for the drug Solpadein

At a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life of the drug Solpadeine

Do not use after the expiration date stated on the package.

Abbott Nutrition Ltd SMITHKLINE BEECHAM CONSUMER HEALTHCARE SmithKline Beecham Liquides Industrie STERLING HEALTH Glaxo Wellcome GmbH & Co. Glaxo Wellcome Production GlaxoSmithKline GmbH & Co. KG/Heumann Pharma GmbH GlaxoSmithKline Dungarvan Ltd. GlaxoSmithKline Consumer Healthcare GlaxoSmithKline Consumer Healthcare/Glaxo Welcome Pr GlaxoSmithKline Consumer Healthcare/Dungarvan Limited Famar S.A.

Country of origin

Greece Ireland Spain France

Product group

Painkillers

Combined analgesic non-narcotic drug

Release forms

2 - strips (2) - cardboard boxes. 2 - strips (4) - cardboard boxes. 2 - strips (6) - cardboard boxes. 2 - strips (12) - cardboard boxes. 2 - strips (30) - cardboard boxes. 2 - laminated strips (6) - cardboard packs 2 - laminated strips 46) - cardboard packs. 6 - blisters (1) - cardboard boxes. 6 - blisters (2) - cardboard boxes. 12 - blisters (1) - cardboard boxes. 12 tablets per blister (2), placed in a card. pack.

Description of the dosage form

Hard gelatin capsules, size No. 0, with biconvex spherical ends, opaque, with a red to red-brown cap and a white body, with the inscription “Solpadeine” printed in black on both parts of the capsule; the contents of the capsules are a white amorphous powder, including white tablets, coated with a capsule-shaped film shell with a flat edge. On one side of the tab there is a sign in the form of a triangle or +. The tablets are white, capsule-shaped, elongated, marked in red “Solpadeine” on one side. Soluble tablets are white, flat, with a circumferential edge and a score line on one side. Soluble tablets are white, flat, chamfered, smooth on one side and scored on the other.

Pharmacological action

An analgesic-antipyretic of a combined composition, contains a combination of two active ingredients: paracetamol and caffeine. Has antipyretic and analgesic effects. Paracetamol blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa. Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance.

Pharmacokinetics

Data on the pharmacokinetics of the drug Solpadeine Fast are not provided.

Special conditions

Excessive consumption of tea and coffee is not recommended while taking the drug, because this can lead to agitation, sleep disturbance, tachycardia, cardiac arrhythmia. In cases of long-term use in high doses, monitoring of the blood picture is necessary. To avoid toxic liver damage, patients taking Solpadeine Fast should refrain from drinking alcohol. It is not recommended to prescribe the drug for chronic alcoholism. Patients with atopic bronchial asthma and hay fever have an increased risk of developing allergic reactions. For patients on a salt-free or low-salt diet, the sodium content of the tablet (427 mg) should be taken into account when calculating daily salt intake. When conducting tests to determine uric acid and blood glucose levels, you should inform your doctor about taking the drug. Solpadeine Fast can change the results of doping control tests for athletes. The drug should be used with caution if you are intolerant to fructose, since the drug contains sorbitol. Overdose In case of overdose, you should immediately seek medical help, even if you feel well. Symptoms of paracetamol overdose: nausea, vomiting, stomach pain, pale skin, anorexia. After 1-2 days, signs of liver damage are determined. In severe cases, liver failure and coma develop. Treatment: perform gastric lavage, prescribe adsorbents (activated carbon), carry out symptomatic therapy.

Compound

1 tab. paracetamol 500 mg codeine phosphate hemihydrate 8 mg caffeine 30 mg Excipients: soluble starch, corn starch, povidone, potassium sorbate, microcrystalline cellulose, purified talc, stearic acid, magnesium stearate, ethanol 95%, demineralized water, hydroxypropyl methylcellulose, carmazine (E122) . 1 tab. paracetamol 500 mg caffeine 65 mg 1 tab. paracetamol 500 mg codeine phosphate hemihydrate 8 mg caffeine 30 mg Excipients: sodium bicarbonate, sorbitol, sodium saccharin, sodium lauryl sulfate, anhydrous citric acid, anhydrous sodium carbonate, polyvidone, dimethicone. 1 tab. paracetamol 500 mg caffeine 65 mg paracetamol 500 mg caffeine 65 mg Excipients: sorbitol, sodium saccharinate, sodium bicarbonate, povidone, sodium lauryl sulfate, dimethicone, citric acid, sodium carbonate.

Solpadeine indications for use

Pain syndrome in adults and children over 12 years of age, including: - headache; - toothache; - migraine; - pain in muscles and joints; - neuralgia; - painful menstruation; - for radiculitis; - with sprains; - for sinusitis; - sore throat. To reduce elevated body temperature in adults and children over 12 years of age with colds, other infectious and inflammatory diseases and flu.

Solpadeine contraindications

- severe dysfunction of the liver or kidneys; - blood diseases (thrombocytopenia, anemia); - genetic absence of glucose-6-phosphate dehydrogenase; - glaucoma; - respiratory failure, conditions after traumatic brain injury, increased intracranial pressure; - arterial hypertension; - simultaneous use of other paracetamol-containing drugs; - pregnancy; - period of breastfeeding; - children's age (up to 12 years); - increased individual sensitivity to paracetamol, codeine, caffeine or any other ingredient of the drug. The drug should be used with caution in Gilbert's syndrome (constitutional hyperbilirubinemia), congenital hyperbilirubinemia (Dubin-Johnson and Rotor), bronchial asthma, and in old age.

Solpadeine side effects

Allergic reactions: rash, itching, Quincke's edema. From the digestive system: dyspeptic disorders (including nausea, epigastric pain). From the hematopoietic system: rarely - leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia. Other: sleep disturbance, tachycardia. At recommended doses, the drug is usually well tolerated. With long-term use in high doses, the likelihood of hepatotoxicity, nephrotoxicity and pancytopenia increases.

Drug interactions

When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Enhances the effect of MAO inhibitors. Barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants and other inducers of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe intoxication with small overdoses. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity. Under the influence of paracetamol, T1/2 of chloramphenicol increases 5 times. Caffeine accelerates the absorption of ergotamine. The simultaneous use of paracetamol and ethanol increases the risk of developing hepatotoxic effects and acute pancreatitis. Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the effectiveness of uricosuric drugs.

Overdose

Symptoms: nausea, vomiting, stomach pain, sweating, pale skin, tachycardia; with mild intoxication - ringing in the ears; in case of severe intoxication - confusion, drowsiness, collapse, convulsions, bronchospasm, difficulty breathing. Treatment: perform gastric lavage.

Storage conditions

keep away from children
store in a place protected from light

Information provided

Solpadeine is an analgesic drug containing a combination of 3 main components: codeine, paracetamol and caffeine.

Codeine and paracetamol have an analgesic and antipyretic effect. They help improve pain tolerance. Caffeine reduces the feeling of fatigue, increases physical endurance and mental alertness.

Compound

The drug is available in several forms: capsule-shaped and soluble tablets. It contains a mixture of 3 ingredients: paracetamol, codeine phosphate hemihydrate, as well as other auxiliary components: magnesium stearate, corn starch, stearic acid, ethanol, microcrystalline cellulose, povidone, potassium sorbate, carmazine and others.

Doctors recommend taking the drug orally after eating food. The rules for treating this medication depend on the person’s age. Adults and children over 16 years of age can take 1 to 2 tablets 3 to 4 times a day. The interval between taking tablets should not be 4 hours. In this case, the maximum permissible single dose is 2 tablets, and the daily dose is 8 tablets.

Children whose age ranges from 12 to 16 years should take from 1 to 4 tablets per day. The maximum permissible single dosage is 1 tablet, and the daily dosage is 4 tablets.

What does Solpadeine help with?

This medicine is effective for pain of various etiologies. It is recommended for children whose age has exceeded the mark of 12 years, as well as for adults with pain syndrome. Solpadeine normalizes body temperature in case of colds, infectious and inflammatory pathologies.

Contraindications

Among the contraindications to the use of this medication are the following conditions:

deficiency of glucose-6-phosphate dehydrogenase;
respiratory failure;
pregnancy and breastfeeding;
old age;
diseases of the circulatory system;
glaucoma is a group of eye diseases characterized by increased intraocular pressure with subsequent development of visual defects;
high blood pressure;
dysfunction of the liver and kidneys;
hypersensitivity to the ingredients present in this medication;
bronchial asthma;
children up to 12 years of age.

Adverse reactions

In medical practice, a small number of cases of adverse reactions occurring due to the use of this drug have been recorded. As a rule, such an effect occurs due to improper treatment with Solpadeine. Therefore, it is very important to take this medication strictly according to the instructions.

If you use this medicine incorrectly, you may experience the following:

skin rash;
sleep disturbance;
pain in the stomach;
sweating;
tinnitus;
confusion;
dizziness;
constipation;
Quincke's edema;
nausea;
anemia;
rapid heartbeat;
thrombocytopenia;
cramps and other unpleasant symptoms.

If you feel unwell while taking this medication, stop using this medication, consult a doctor and, if necessary, do a gastric lavage and drink activated charcoal.

Best before date

This drug must be stored in a dark place, out of reach of children, at a temperature not exceeding 25°C. The shelf life of the medicine depends on the form of its release and varies from 4 to 5 years.

Name:

Solpadein

Pharmacological
action:

A combined drug whose effect is determined by the properties of its constituent components. Has an analgesic (pain-relieving) effect.

Inhibits PG synthesis, reduces the excitability of the heat and cough centers, and enhances heat transfer.

Pharmacokinetics
Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract; plasma concentration reaches a peak value after 15–60 minutes. T1/2 in plasma - 1–4 hours. Relatively evenly distributed in the body, 20–30% bound to plasma proteins. Excreted in the urine in the form of metabolites (when taking a therapeutic dose, 100% is excreted in the urine within 24 hours). Codeine phosphate is well absorbed from the gastrointestinal tract and is biotransformed in the liver to metabolites (morphine, norcodeine, etc.). It is excreted from the body in the urine, mainly in the form of compounds with glucuronic acid. T1/2 in plasma is 3–4 hours. Caffeine is rapidly absorbed, Cmax is reached in 20–60 minutes, T1/2 is about 4 hours. Within 48 hours, about 45% is excreted in the urine in the form of 1-methylurea acid and 1-methylxanthine .

Pharmacodynamics
Paracetamol exhibits antipyretic and analgesic effects, selectively inhibiting the synthesis of PG in the central nervous system. Codeine, by stimulating opiate receptors in the brain, changes the nature of pain perception and suppresses cough. Caffeine enhances the analgesic properties of paracetamol and codeine due to its stimulating effect on the central nervous system, can eliminate depression associated with pain and, in addition, by increasing the permeability of histohematological barriers, increases the concentration of other components of Solpadeine in the brain.

Indications for
application:

Migraine,
- headache,
- periodic toothache,
- neuralgia (pain spreading along the nerve),
- cold,
- flu,
- pharyngitis (inflammation of the pharynx),
- fever (sharp increase in body temperature),
- rheumatic diseases.

Directions for use:

Before taking, solpadeine should be dissolved in a glass of water.
For adults Prescribe 2 tablets every 4 hours. The maximum daily dose is 8 tablets.
For children at the age of 7 to 12 years, 2-1 tablets are prescribed no more than every 4 hours, the maximum daily dose is 4 tablets.
Children should not take the drug for more than 3 days.

Side effects:

Nausea, vomiting, dizziness, insomnia, nervous agitation, constipation, allergic reactions (skin rashes).

Contraindications:

Hypersensitivity, acute attacks of bronchial asthma, respiratory failure, head injuries, increased intracranial pressure, conditions after operations on the biliary tract.

Interaction with
other medicinal
by other means:

Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol.

Precautions
Solpadeine should not be used together with other paracetamol-containing drugs; children under 12 years of age should not be given capsules, tablets, and children under 7 years of age should be given soluble tablets. It is not recommended to violate the dosage regimen - no more than 4 doses in 24 hours. Take with caution in case of acute kidney diseases and liver diseases in combination with MAO inhibitors, against the background of alcohol. Excessive consumption of coffee and tea can cause tension and irritability.

Pregnancy:

Solpadeine contraindicated during pregnancy. During breastfeeding it is permissible, but after consultation with a doctor.

Overdose:

Complications from overdose are most likely in patients with non-cirrhotic liver damage.
Symptoms- pallor, nausea, vomiting, anorexia, abdominal pain, signs of circulatory and respiratory depression, tremor, nervousness, irritability.
Treatment- in case of an overdose of paracetamol, take meglonine orally or intravenously with N-acetylcysteine; in case of caffeine overdose - gastric lavage, in severe cases - artificial ventilation, use of oxygen and naloxone.