Is amoxiclav a strong antibiotic? The drug Amoxiclav - patient reviews and expert opinion

Amoxiclav is a broad-spectrum bactericidal antibacterial drug. Belongs to the penicillin group. Tablets for children and adults contain an antibiotic (amoxicillin trihydrate) and an enzyme inhibitor, which is the potassium salt of clavuanic acid. It enhances the antimicrobial effect by reducing the activity of beta-lactamase.

Instructions for use of Amoxiclav indicate the ability of the drug to have a bactericidal and bacteriostatic effect on most gram-negative and gram-positive microorganisms.

In this article we will look at when doctors prescribe the drug Amoxiclav, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Amoxiclav, leave your feedback in the comments.

Composition and release form

Clinical and pharmacological group: broad-spectrum penicillin antibiotic with beta-lactamase inhibitor. Release form:

Tablets 250+125 mg: white or off-white, oblong, octagonal, biconvex, film-coated tablets, imprinted “250/125” on one side and “AMC” on the other side. Each 250mg+125mg tablet contains 250 mg of amoxicillin in the form of trihydrate and 125 mg of clavulanic acid in the form of potassium salt.
Tablets 500+125 mg: white or almost white, oval, biconvex film-coated tablets. Each 500mg+125mg tablet contains 500 mg of amoxicillin in the form of trihydrate and 125 mg of clavulanic acid in the form of potassium salt.
Tablets 875+125 mg: white or off-white, oblong, biconvex, film-coated tablets, scored and imprinted “875” and “125” on one side and “AMC” on the other side. Each 875mg+125mg tablet contains 875 mg amoxicillin trihydrate and 125 mg clavulanic acid potassium salt.

The product is also produced in the form of a powder from which a suspension is made; the bottle contains powder for preparing 100 ml of the product.

A powder is also produced, from which a solution is made, which is administered intravenously. The bottle holds 600 mg of the product (amoxicillin 500 mg, clavulanic acid 100 mg), 1.2 g bottles are also available (amoxicillin 1000 mg, clavulanic acid 200 mg), the package holds 5 bottles.

Pharmacological action

Amoxiclav is a broad-spectrum antibiotic; contains semisynthetic penicillin amoxicillin and b-lactamase inhibitor clavulanic acid. Clavulanic acid inhibits most clinically significant b-lactamases (types 2, 3, 4 and 5 - according to the Richmond Sykes classification) produced by Staphylococcus spp., Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides spp. Inactive against type 1 b-lactamases produced by Enterobacter spp., Morganella morganii, Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

Indications for use

Amoxiclav is prescribed for infectious and inflammatory diseases that develop due to the influence of microorganisms sensitive to this medicine.

The following indications for the use of this drug are determined:

infections of the upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis);
infections of the lower respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);
urinary tract infections;
gynecological infections;
skin and soft tissue infections, including animal and human bites;
infections of bone and connective tissue;
biliary tract infections (cholecystitis, cholangitis);
odontogenic infections.

What else Amoxiclav helps with, you should ask a specialist during an individual consultation.

Instructions for use

Amoxiclav tablets are taken orally, preferably after meals. According to the instructions for use, the dosage depends on the severity of the infectious process and the age of the patient.

Adults and children over 12 years of age (or with a body weight >40 kg) with mild or moderate infection are prescribed 1 tablet. (250 mg+125 mg) every 8 hours or 1 tablet. (500 mg + 125 mg) every 12 hours, in case of severe infection and respiratory tract infections - 1 tablet. (500 mg+125 mg) every 8 hours or 1 tablet. (875 mg+125 mg) every 12 hours.
The drug in tablet form is not prescribed to children under 12 years of age (with body weight<40 кг). В этом случае лучше использовать лекарственную форму в виде суспензии. Максимальная суточная доза клавулановой кислоты (в форме калиевой соли) составляет для взрослых – 600 мг, для детей – 10 мг/кг массы тела. Максимальная суточная доза амоксициллина составляет для взрослых – 6 г, для детей – 45 мг/кг массы тела.

The dosage regimen is set individually depending on the age, body weight, kidney function of the patient, as well as the severity of the infection. The course of treatment is 5-14 days. The duration of treatment is determined by the attending physician. Treatment should not continue for more than 14 days without repeated medical examination.

Contraindications

hypersensitivity to any of the components of the drug;
history of hypersensitivity to penicillins, cephalosporins and other beta-lactam antibiotics;
a history of indications of cholestatic jaundice and/or other liver dysfunction caused by taking amoxicillin/clavulanic acid;
infectious mononucleosis and lymphocytic leukemia.

The drug should be prescribed with caution in case of allergic reactions to cephalosporins and a history of pseudomembranous colitis, liver failure, severe renal dysfunction.

Side effects

Side effects are usually temporary and mild in severity.

From the digestive system: possible loss of appetite, nausea, vomiting, diarrhea; rarely – transient increase in the activity of liver enzymes (ALT, AST), liver dysfunction; in isolated cases - cholestatic jaundice, hepatitis, pseudomembranous colitis.
From the nervous system: rarely - agitation, anxiety, headache, dizziness, inappropriate behavior, insomnia, convulsions, confusion, hyperactivity.
From the blood system: thrombocytopenia, anemia (including cases of hemolytic anemia), leukopenia, eosinophilia, agranulocytosis.
Allergic reactions: erythematous rash, itching, urticaria; rarely – exudative erythema multiforme, angioedema, anaphylactic shock; in isolated cases - exfoliative dermatitis, Stevens-Johnson syndrome.
Hepatobiliary disorders: Increased liver function test parameters may occur, including increased activity (asymptomatic) of ALT and/or AST, alkaline phosphatase and serum bilirubin levels. Liver dysfunction usually develops in elderly patients or in patients prescribed long-term drug therapy. Hepatitis and cholestatic jaundice develop quite rarely.
From the urinary system: hematuria and interstitial nephritis (rare).

Other: rarely - development of superinfection (including candidiasis); reversible increase in prothrombin time (when used together with anticoagulants).

Overdose

There are no reports of death or life-threatening side effects due to drug overdose.
In most cases, symptoms of overdose include gastrointestinal disorders (abdominal pain, diarrhea, vomiting). Anxiety, insomnia, dizziness, and, in isolated cases, seizures are also possible.

In case of overdose, the patient should be under medical supervision and treatment should be symptomatic. In case of recent use (less than 4 hours), it is necessary to perform gastric lavage and prescribe activated charcoal to reduce absorption.

Special instructions

Due to the fact that an erythematous rash was observed in a large number of patients with infectious mononucleosis and lymphocytic leukemia who received ampicillin, the use of ampicillin antibiotics for such patients is not recommended.

Since amoxicillin and clavulanic acid combination tablets of 250 mg + 125 mg and 500 mg + 125 mg contain the same amount of clavulanic acid - 125 mg, then 2 tablets of 250 mg + 125 mg are not equivalent to 1 tablet of 500 mg + 125 mg.

During a course of treatment, the functions of hematopoiesis, liver and kidneys should be monitored. In patients with severe renal impairment, adequate adjustment of the dosage regimen or increased intervals between dosing is required. In order to reduce the risk of developing adverse reactions from the gastrointestinal tract, the drug should be taken with meals.

Prices

The average price of AMOXICLAV, 250 mg tablets in pharmacies (Moscow) is 250 rubles. Price for 500 mg 400 rubles

Analogues

Structural analogues of the active substance:

Amovycombe;
Amoxiclav Quiktab;
Arlet;
Bactoclav;
Verklav;
Clamosar;
Liklav;
Honeyclave;
Panclave;
Ranklav;
Rapiklav;
Taromentin;
Ecoclave.

Attention: the use of analogues must be agreed with the attending physician.

Storage conditions

In a dry place at a temperature not exceeding 25°C. Keep out of the reach of children.

Hello friends! Today I will tell you about the indications for use of amoxiclav, as well as what forms and dosages of this drug can be given to children.

In the previous article I talked about its composition and its analogues.

Now that we know the mechanism of its action, let’s figure out which diseases it is most effective for.

Amoxiclav indications for use

If you remember, in the last article I said that this medicine is unique. The uniqueness lies in the fact that the enzymes that bacteria secrete to protect against medications are not able to destroy its active substance.

This is what allows it to be used for a wide variety of diseases. And its property of being harmoniously distributed in the tissues of the body is suitable for combating pathogens living in a variety of places.

Here are the indications for use of amoxiclav by doctors:

1.Upper respiratory tract infections:

Tonsillitis,
Sinusitis,
Retropharyngeal abscess,
Pneumonia,
ENT – infections.

2. Infections of the genitourinary system:

Cystitis,
Urethritis,
Pyelonephritis,
Prostatitis.

3. Gynecological diseases:

Sepsis,
adnexitis,
endometritis.

4. Biliary tract infections:

Cholecystitis,
Cholangitis.

5.Venereal diseases:

Gonorrhea,
Syphilis.

At the same time, the medication has indications for use in the fight against infectious agents developing in various tissues (bone, connective, muscle, mucous).

What do the indications for amoxiclav use say about the dosage?

The method of application and its dosage differ in each individual case. The severity of the disease, the patient’s age, the condition of the liver and kidneys, and anthropometric data are taken into account.

Also, the indications for use indicate that the usual course of treatment is two weeks, and the daily dosage is calculated based on the patient’s weight.

It is worthwhile to dwell in more detail on the method of treating children.

It is known that this medication is available in several different forms that correspond to its intended purpose. These could be:

ampoules for intramuscular or intravenous administration,
tablet forms with different quantitative compositions of amoxicillin and clavulanic acid,
instant pills,
powder for preparing suspension

It's no secret that treating children has its own characteristics. You yourself know that it is difficult to explain to them that something healthy can be tasteless and disgusting.

Therefore, especially for such cases, a powder for the preparation of amoxiclav suspension for children is being produced.

In addition to the main components, fruit flavors and sweet ingredients are added to the powder so that the suspension has a pleasant taste and is liked by children.

The Forte variety contains a double dose of antibiotic. This suspension is prescribed for severe forms of infection:

Sinusitis,
Bronchitis,
Pneumonia.

What else do they write about Amoxiclav indications for use?

Please note that for newborns and children up to 3 months old, the dosage of the medicine should not exceed 30 mg per kilogram of body weight per day. To facilitate the preparation of the drug, a measuring spoon or pipette is always attached to it.
For older children, the dosage is prescribed according to the severity of the disease, and can range from 20 to 40 milligrams per kilogram of weight.
And for children over 12 years old and weighing more than 40 kilograms, the prescription is given according to an adult scheme, but a prerequisite is control over the functioning of the liver.

Speaking about the indications, I was asked why doctors rarely prescribe this medication for sore throat, therefore, I want to talk about this in more detail.

Let's start with the fact that the causative agents of sore throat can be bacteria, viruses or fungi.

Therefore, it is reasonable to prescribe amoxiclav for angina only if it is established that the causative agents are bacteria.

In any other case, treatment will be ineffective and will do more harm than good. For example, side effects are indicated in the indications for use.

Therefore, for the treatment of sore throat, antibiotics are prescribed only after preliminary microbiological tests to identify the pathogen and its sensitivity to drugs.

In conclusion, let me give you some advice. Perhaps analogues such as Augmentin or Flemoxin will be more effective for you.

By the way, if you know what other indications amoxiclav has for use, which I did not mention in the article, write comments.

Amoxiclav is a combination drug that contains semisynthetic penicillin and clavulanic acid. This drug is used for antibacterial therapy for many diseases of infectious etiology.

Table of contents: Dosage forms and composition of Amoxiclav Pharmacological action What diseases does Amoxiclav help with? Who is Amoxiclav contraindicated for? Recommended dosages Side effects Overdose Interaction of Amoxiclav with other drugs Amoxiclav during pregnancy and breastfeeding Additional Rules for storage and dispensing from pharmacies Analogues of Amoxiclav

Amoxiclav is produced in the form of regular and dispersible tablets, which contain the β-lactam antibiotic amoxicillin (250, 500 or 875 mg amoxicillin trihydrate) and the β-lactamase inhibitor clavulanic acid (125 mg potassium clavulanate).

The product is available in the form of a ready-made suspension and powder for its own preparation.. 5 ml of suspension contains 125, 250 or 400 mg of semi-synthetic penicillin, as well as 31.25, 62.5 or 57 mg of the potassium salt of clavulanic acid, respectively.

The liquid form is supplied in bottles of 35, 50, 70 and 140 ml, and the tablet form is supplied in blisters of 2, 5, 6, 8 and 20 pieces.

Amoxicillin is an antibiotic that is active against a wide range of pathogenic microflora. Many bacteria synthesize β-lactamase, which makes penicillin drugs ineffective. Therefore, the composition includes an inhibitor of this enzyme – clavulanic acid. Its potassium salt forms a stable inactive complex with the enzyme that destroys the antibiotic.

The drug is evenly distributed in the tissues and fluids of the body. After oral administration, the highest plasma concentration is recorded after 60 minutes. The degree of bioavailability of amoxicillin trihydrate is 90%, and potassium clavulanate is about 70%.

The process of biotransformation of drugs occurs in the liver, and the unchanged substance and its metabolites are excreted mainly in the urine.

This antibiotic is effective against infectious diseases caused by bacteria sensitive to β-lactam drugs.

Indications for the use of Amoxiclav are:

sinusitis (acute or chronic);
otitis;
pharyngitis;
inflammation of the tonsils;
retropharyngeal abscess;
bronchitis;
pneumonia;
cystitis;
pyelonephritis;
cholecystitis;
cholangitis;
infectious dermatitis;
sexually transmitted diseases (in particular, gonorrhea);
infected wounds (including after insect and animal bites);
gynecological diseases of infectious origin;
arthritis (with an infectious component);
osteomyelitis.

The drug is contraindicated in persons with individual hypersensitivity to active or auxiliary ingredients, as well as with hypersensitivity to other penicillin antibacterial agents. Caution must be exercised if there is a history of allergy to cephalosporins.

Please note

You should not take Amoxiclav if the use of amoxicillin in combination with clavulanic acid has caused liver dysfunction or bile stagnation.

Other contraindications include:

severe renal dysfunction;
lymphocytic leukemia;
pseudomembranous colitis;
liver failure (due to hepatitis or alcohol damage);
infectious mononucleosis.

This antibacterial agent in tablet form is not prescribed to children and adolescents under 12 years of age.

Please note

Amoxicillin is intended for course treatment; The course duration ranges from 5 days to 2 weeks. Prolonged uncontrolled use and interruption of the course can contribute to the formation of antibiotic resistance in pathogenic microflora.

In terms of amoxicillin, for mild or moderate infection, take 250 mg of the drug at 8-hour intervals (3 tablets per day).

For severe bacterial infections and diseases of the respiratory system, 500 mg every 8 hours or 100 mg 2 times a day is indicated.

The maximum specified dose of amoxicillin trihydrate for patients over 12 years of age is 6 g, and potassium clavulanate is 600 mg.

Children under 12 years of age can be given a suspension. The dosage is determined at the rate of 45 mg/kg/day. (for amoxicillin) and 10 mg/kg/day. (for clavulanic acid). To make the liquid form easier to measure, the package includes pipettes or 5 ml measuring spoons.

Please note

Odonotogenic infections (periodontitis, periostitis) require taking 250/125 mg tablets 3 times a day for 5 days.

For suspensions of 125 and 250 mg of amoxicillin per 5 ml:

Babies in the first 3 months of life are given 30 mg/kg of the drug per day, dividing the dose into 2 doses. Children from 3 months. prescribed (depending on the severity of the infectious process) from 20 to 40 mg/kg per day, dividing the volume into 3 doses.

For suspensions of 400 mg/5 ml:

Amoxiclav with a high concentration of the antibacterial component is given at 25-45 mg/kg/day. for severe infections, dividing the dose into 2 doses.

Please note

To prepare a suspension, add boiled or distilled water to the bottle with powder, close the container with a lid, and shake vigorously until a homogeneous liquid is obtained.

Side effects

Most patients tolerate a course of antibiotic therapy with Amoxiclav without complications. In case of individual intolerance, allergic reactions may develop in the form of skin itching, rashes (urticaria) and angioedema. In severe situations, anaphylactic shock cannot be ruled out.

In rare cases, the following undesirable effects have been observed:

dyspeptic disorders;
anorexia (deterioration or loss of appetite);
diarrhea;
liver failure;
hepatitis;
cholestasis (accompanied by yellowness of the sclera and skin);
candidiasis (against the background of dysbacteriosis);
superinfections (when the microflora develops resistance).

If age-related single and (or) daily dosages are significantly exceeded, various disorders of digestive function and water-salt imbalance are possible. Renal dysfunction is also possible.

Against the background of an overdose, psychomotor agitation, unmotivated feelings of anxiety, sleep disturbances and convulsions are sometimes noted.

The victim requires stomach cleansing and symptomatic therapy. It is advisable to give the patient enterosorbents (according to age indications, these can be activated carbon, Smecta, Enterosorb, etc.). In severe situations, it may be necessary to hospitalize the victim in a specialized hospital department and perform hardware blood purification - hemodialysis.

Plasma concentration of the antibiotic increases during administration Probenecida.

Amoxiclav increases overall toxicity Methotrexate due to slower excretion of the latter.

When combined with Allopurinol the risk of exanthema (skin rashes) increases.

The effectiveness of amoxicillin may be reduced when taken in parallel with macrolide antibiotics, tetracycline agents And sulfonamides.

A combined antibacterial drug can reduce the effectiveness birth control pills, because it interferes with their absorption.

Antagonism between Amoxiclav and Rifampicin(the therapeutic effect is mutually weakened).

Parallel use with indirect anticoagulants leads to an increase in prothrombin time, which increases the risk of bleeding of various locations.

Amoxicillin freely penetrates the blood-placental barrier, but this antibiotic does not have mutagenic, teratogenic or embryotoxic properties. Pregnant women can take it only as prescribed by their doctor. If it is necessary to carry out antibiotic therapy during lactation, the question may be raised about temporarily transferring the baby to artificial milk formula, although only a very small amount of antibiotic passes into breast milk.

To reduce the likelihood of dyspeptic disorders, it is advisable to drink Amoxiclav immediately after meals.

You do not need a doctor's prescription to purchase Amoxiclav.

The medicine should be stored in a place shielded from sunlight, at a temperature not exceeding +25°C.

The shelf life for suspension and tablets is 2 years from the date of issue (marked on the factory container).

Keep away from children!

Analogue drugs based on the active substance and mechanism of action include:

Panclave;
Augmentin;
Sumamed;
Oxamp;
Ranklav;
Ecoclave;
Arlet;
Rapiklav.

Plisov Vladimir, doctor, medical observer

Amoxiclav is used in gynecology, urology, and otolaryngology. This medicine is an antibiotic that contains amoxicillin and clavulanic acid.

Amoxiclav is a semi-synthetic penicillin that inhibits enzymes of pathogenic bacteria along the biosynthesis path. This leads to the death of the malicious infection.

Release form: tablets and suspension. In obstetrics, pills are prescribed for women. The suspension is recommended for children under 12 years of age.

Analogues of the drug Amoxiclav:

Oxamp;
Ecoclave;
Arlet;
Augmentin;
Rapiklav.

For what diseases should you take Amoxiclav?

chlamydia;
ureaplasma;
gonorrhea;
dysbacteriosis of the mucous membrane in combination with streptococcus or staphylococcus.

Amoxiclav has shown particular effectiveness in gynecology in the treatment of ureaplasmosis. Instructions for use for Amoxiclav contain information that the drug is prescribed for chlamydia. But doctors recommend giving preference to Vilprafen in this pathology, because, as practice shows, chlamydia has become immune to Amoxiclav.

Contraindications:

individual intolerance to components;
history of hypersensitivity to antibacterial penicillin drugs;
infectious mononucleosis and lymphocytic leukemia;
disruption of the gallbladder, liver damage due to antibiotics;
chronic renal failure.

The tablets should be taken with plenty of water. It is better to take the medicine after meals. Thus, the components of the medication will not affect the mucous membranes of the gastrointestinal tract.

The dosage of the drug is determined by the gynecologist for each individual patient. It all depends on the type of pathology, severity, age of the woman, general condition of the body, and the presence of other pathologies in the anamnesis.

The duration of therapy is from 5 days to 2 weeks. For the treatment of pathologies of mild and moderate severity, it is recommended to take 1 tablet (250) 3 times every 8 hours or 2 times throughout the day every 12 hours. For the treatment of severe pathologies - 1 tablet (500) 3 times a day or 1 tablet (875) mg every 12 hours.

Side effects:

nausea, vomiting, diarrhea;
yellowness of the skin;
migraines;
skin rash, swelling.

With prolonged use of the medicine, dysbacteriosis may develop, and yeast-like fungi may develop on the skin and mucous membranes. Therefore, there is no need to self-medicate. The exact dosage prescribed by the gynecologist should be followed. No cases of overdose have been recorded.

Judging by the reviews of women who took Amoxiclav, side effects occur extremely rarely.

Use of Amoxiclav during pregnancy and lactation

Gynecological diseases very often develop during pregnancy. Amoxiclav is allowed to be taken during pregnancy and breastfeeding. This antibiotic is one of the few that does not have a harmful effect on the fetus. Amoxiclav acts only on infection, without affecting the intrauterine development of the fetus.

The drug is prescribed after the woman undergoes a gynecological examination. Based on indications and examination results, a course of antibacterial therapy is prescribed.

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In the modern world, there are more and more throat diseases that require treatment with antibiotics. The most dangerous are bacterial infections that give purulent complications.

The need to take antibiotics often arises in advanced (chronic) diseases, as well as when complications arise after a viral infection. If the course of the disease allows, it is better to test for sensitivity to certain antibiotics in order to carry out effective treatment. It is usually rarely possible to determine the type of bacteria before starting treatment. Antibiotics that have a fairly wide range of effects are usually used.

Such drugs include Amoxiclav, a combination drug that includes the following substances:

amoxicillin from the penicillin group,
clavulanic acid, which enhances the effect of the antibiotic.

The components of the drug are quickly absorbed in the stomach and have a short elimination period. In this regard, treatment is carried out for a duration of 1 to 2 weeks, divided into several doses throughout the day.

When taking the medicine, you must drink enough fluid to prevent dehydration.

This medicine is used:

inflammation of the middle ear,
sinusitis,
sore throat,
pharyngitis,
purulent infections of the tonsils.

Amoxiclav is produced in the form of:

tablets,
powder for suspensions,
in bottles.

The type of drug and dose are determined by the doctor in accordance with the symptoms, nature and duration of the disease, as well as the age of the patient.

Main types of medicinal product:

pills,
powder for preparing a suspension (for treating children),
powder from a bottle for parenteral use.

Amoxiclav tablets contain:

clavuanic acid – 125 g,
amoxicillin – 250-500-875 mg.

For illness with low-grade fever, both adults and children are prescribed 1 tablet of the drug (250 mg amoxicillin) three times a day, with an interval of eight hours.

In the case of sore throat with a higher temperature, the following dosage regimen is used: amoxicillin 500 mg with clavuanic acid - 125 g. In this case, it is enough to take 1 tablet 2 times a day with an interval of 12 hours.

In especially severe cases, the drug is prescribed 500 mg of amoxicillin 3 times a day, with an interval of eight hours.

The medicine in tablets can be used by chewing or dissolving in water.

This is important! Amoxiclav tablets can be given to children weighing over 40 kg.

To avoid side effects and harmful effects on the gastric microflora, it is better to take the drug immediately before meals.

The duration of treatment is determined by the doctor. There is one generally accepted rule - for a period of no more than 2 weeks.

In particularly severe cases of tonsillitis or other inflammatory diseases, amoxiclav must be administered intravenously. Injections are used to achieve a more stable patient’s condition with the ability to subsequently switch to tablets.

For intravenous administration, take sterile powder of the drug in vials, dilute it with water for injection, inject it into a vein very slowly or slowly inject it over 30 minutes. Such manipulations are carried out up to three times a day, monitoring the patient’s condition.

When treating tonsillitis and other inflammatory diseases in children, the medicine is usually used in the form of a suspension. In pediatrics, the dosage is calculated individually by the attending physician for each small patient. The calculations take into account the weight and age of the child, as well as the severity of the disease.

The daily amount of the drug for children over 3 months of age, based on amoxicillin, is thirty mg/kg.

So, if the patient weighs 8 kg, the daily dose of amoxicillin will be 240 mg. The drug in the form of a suspension is divided into two doses - 120 mg per dose and given to the patient at regular intervals with an interval of 12 hours.

For a patient weighing up to 40 kg (children from three months and older), the medicine is prescribed in a dosage of 20-25 mg per kg for moderate severity of the disease to 40-45 mg per kg in severe cases. The daily dose is divided into 2-3 doses. Very rarely, when treating young patients, there is a need for intravenous administration of antibiotics when the child cannot swallow independently in particularly severe cases of the disease.

Very often, it is difficult for parents of small children to correctly calculate the amount of suspension, since the doctor’s prescription most often contains only the amount of the active substance (amoxicillin, clavuanic acid), and not the amount of suspension.

When prescribing a medicine, you need to check with your doctor, down to the gram, in what proportion water is added to the powder, as well as how many milliliters of suspension to give to the child.

All active ingredients of amoxiclav will be excreted by the kidneys at the same time, so in people suffering from renal failure the drug may be delayed. In this case, it is necessary to monitor the concentration of the drug in blood and urine and individually adjust the dosage and intervals of taking the medication. An antibiotic can give a false-positive urine test for glucose, which should also be taken into account for an objective interpretation of the test result.

Amoxiclav should not be taken by people who have previously had allergic reactions to antibiotics such as penicillins or cephalosporins.

It has been scientifically proven that in patients suffering from infectious mononucleosis, the use of this drug can lead to the appearance of an allergic skin rash. Therefore, it is better for such people to use another drug.

Amoxiclav is prescribed with caution to pregnant women and people suffering from liver diseases.

Side effects when taking this drug occur extremely rarely, in most cases they are temporary and disappear when you stop taking the drug. If any side effects occur, you should immediately report them to your doctor.

Amoxiclav is an antibiotic that can effectively fight pathogenic microorganisms. What does Amoxiclav help with?

Amoxiclav is used to treat various diseases - tonsillitis, bronchitis and many other pathologies of the ENT organs and respiratory system, as well as the urinary system, infectious processes of the skin and soft tissues, joints and other diseases of infectious and inflammatory origin.

Components and dosage form

Amoxiclav consists of two main components - amoxicillin and clavulanic acid, which differ in composition and, therefore, in their effect on pathogenic microorganisms. This is precisely the effect of the drug. There are also additional components, namely:

talc;
stearic acid;
various flavoring agents;
sodium citric acid salt;
citric acid, etc.

Today, a medicine such as Amoxiclav can be found on pharmacy shelves in the following dosage forms:

tablets containing amoxicillin 250, 500 and 875 mg and clavulanic acid 125 mg in each of three tablet forms, respectively;
powdery substance for preparing a suspension;
powdery substance for solutions for parenteral administration.

Features of therapeutic action

Amoxiclav is a substance that has a wide range of uses and is a member of the penicillin group. Due to the fact that the composition contains clavulanic acid, it ensures the resistance of the remaining components to the enzyme beta-lactamase, which is produced by pathogenic bacteria. The structure of clavulanate is similar to beta-lactam antibiotics, which allows it to fight bacteria.

The presence of amoxicillin allows Amoxiclav to fight anaerobes and various types of bacteria.

What pathological conditions will Amoxiclav help cope with?

In any form, Amoxiclav is prescribed for the treatment of the following diseases and pathological processes:

pathologies of the respiratory tract, as well as bronchitis;
inflammation of the gallbladder;
erysipelas;
meningitis;
sepsis;
abscesses;
skin infections and many others.

Amoxiclav is also taken to prevent postoperative complications.

Contraindications

The use of Amoxiclav is contraindicated in the following pathologies:

when diagnosing a patient with hepatitis or Gospel disease, which progresses due to the use of drugs of the penicillin group;
with mononucleosis of infectious origin;
if the patient is hypersensitive to drugs of the penicillin group and other components that are part of Amoxiclav;
if the patient has lymphocytic leukemia.

Also, with special caution and under the close supervision of a doctor, Amoxiclav should be taken by people who have been diagnosed with pseudomembranous colitis, as well as kidney dysfunction or liver failure.

Amoxiclav is taken for the treatment of diseases during pregnancy and breastfeeding only after the appointment of a treating specialist and exclusively on an individual basis.

How to treat with Amoxiclav?

According to the instructions for the drug, Amoxiclav in tablet form is prescribed to adults and children over 12 years of age.

To prepare a solution for intravenous administration for a dosage of 600 mg of the active substance, add 10 ml of water for injection, for a dosage of 1200 mg - respectively, 20 ml. The liquid is administered intravenously slowly over 3-4 minutes. To prepare an infusion solution for a dropper, the drug, after dissolving in 10 ml (20 ml), is added to 50 ml (100 ml) and administered intravenously over 30-40 minutes.

For mild to moderate illness, Amoxiclav is taken 250+125 mg of active ingredients 3 times a day, with an interval of 8 hours, or 500+125 mg twice a day, with an interval of 12 hours.

In severe forms of the disease, the drug is taken 500+125 mg three times a day or 875+125 mg twice a day, with an interval of 8 and 12 hours, respectively.

Depending on the complications and course of the disease, Amoxiclav is taken for 7-14 days.

Considering that Amoxiclav is also effective for inflammation of the maxillary sinuses, it is taken 500+125 mg three times a day, and the duration of therapy is regulated by a doctor. Please note that for sinusitis, Amoxiclav is not stopped taken even after recovery for about 48 hours, even if the patient has no signs of the disease.

Amoxiclav in the form of a suspension is an excellent treatment option if a child is sick; the dosage is calculated based on the patient’s weight. To prepare the suspension, add 86 ml of water to the powder in two additions and shake the mixture well until the powder dissolves. Before giving the drug to a child, the bottle should also be shaken thoroughly.

For babies under 3 months of age, Amoxiclav is prescribed in the amount of 30 mg per 1 kg of weight. The resulting volume is divided into 2 doses, the time interval between which is 12 hours.

For children over 3 months of age, the amount of the drug is increased: 25 mg is given twice. If the disease is of moderate severity, the drug can be prescribed in an amount of 20 mg per 1 kg of weight, 3 times a day. In more complex cases, the dosage can be 45 mg per 1 kg of weight, 2 times a day.

Amoxiclav, like any other antibacterial drug, has side effects.

The antibiotic Amoxiclav 1000 is a drug effective against microbes with a wide spectrum of action against a wide range of types of bacteria. It contains (or amoxicillin) + clavulanic acid. The functions of the latter are to stop the enzymatic inactivation of penicillin through communication with bacterial beta-lactamases.

Composition of amoxiclav 1000 mg

Amoxiclav 1000 consists of the following substances:

Active:

(in the form of trihydrate) – 875 mg;
Clavulanic acid (as clavunalatacalium) – 125 mg.

Auxiliary:

Crospovidone;
Silicon dioxide;
Magnesium stearate;
Talc;
Cellulose in microcrystals;
Croscamellose sodium.

The film coating consists of the following: titanium dioxide, macrogol 6000, diethyl phthalate, hypromellose, ethylcellulose.

Amoxiclav 1000 is well absorbed into the blood, regardless of the time of meal. The highest concentration in the blood is created after an hour of using this medicine. Traditionally, the course of treatment lasts from 5 to 10 days. This drug should not be taken for more than two weeks without a doctor’s prescription.

What does the number 1000 mean in the name of this medicine? This means that one tablet contains 875 mg of antibiotic (amoxicillin) and 125 mg of clavulanic acid. The total will be a thousand mg or 1 gram.

Indications for use

Otitis;
Tonsillitis;
Chronic bronchitis;
Acute bronchitis;
Abscesses;
Skin inflammation caused by animal bites;
Urinary tract diseases;
Postpartum sepsis;
Infected abortion;
Pelvioperitonitis;
Edometritis;
STDs (sexually transmitted diseases);
To prevent infections during operations.

Efficacy of Amoxiclav 1000 mg against microbes

What aerobes (microbes) is Amoxiclav 1000 mg effective against:

Gram-positive (enterococci, staphylococci, streptococci);
Gram-negative (Escherichia, Klebsiella, Moraxella, Haemophilus influenzae, gonococcus, Shigella, meningococcus).

Amoxiclav 1000 mg tablets are not effective against the following microbes:

Pseudomonas aeruginosa;
Intracellular pathogens (chlamydia, mycoplasma, legionella);
Methicillin-resistant staphylococci;
Bacteria: enterobacter, acitobacter, serration.

There are conditions of the body in which Amoxiclav 1000 tablets cannot be taken:

This medicine is not prescribed to those diagnosed with creatinine clearance less than 30 ml per minute, children under 12 years of age, and patients with phenylketonuria. Pregnant women, and even more so mothers with kidney problems, should use this medicine under the constant supervision of a doctor during breastfeeding. It should be prescribed with caution to those diagnosed with liver failure.

Side effect

Judging by clinical studies and reviews of Amoxiclav 1000 mg, its use can lead to the following negative consequences:

Oral thrush;
Vaginal thrush;
Violation of intestinal microflora;
Skin rashes;
Allergic vasculitis;
Pseudomembranous colitis;
Drug-induced hepatitis;
Cholestatic jaundice (mainly in elderly patients).

Everything listed above occurs extremely rarely; this is not a pattern, but an exception. The increase in the level of biochemical blood test returns to normal after discontinuation of the drug within seven days.

Many side effects, especially those associated with the gastrointestinal tract, can be avoided by taking Linex (live bacteria) or other probiotics simultaneously with the antibiotic we describe.

Analogs of tablets Amoxiclav 1000 mg

Analogues of Amoxiclav 1000 mg:

Abiklav;
Augmentin;
Bactoclav;
Betaclave;
Klavam;
Clavamitin;
Klamox;
Panclave;
Novaklav;
Repiclav;
Theraclave;
Flemoclav;
Sumamed.

Cost of Amoxiclav 1000 and its analogues

The price of Amoxiclav 1000 mg is approximately 440-480 rubles per package, consisting of two blisters, each containing 7 tablets. This cost is due to Swiss production and associated transport costs. German-made amoxiclav will cost approximately 650 rubles. Domestic analogs are cheaper, but not much; the same Augmentin 1000 mg will cost about 300 rubles. This is the cost of this antibiotic.

Interaction with other drugs

Drugs that block tubular secretion increase the concentration of amoxicillin. When taking Amoxiclav with glucosamine and antacids, laxatives simultaneously, absorption slows down. If you drink Amoxiclav and ascorbic acid at the same time, absorption, on the contrary, will accelerate.