Ringer's solution is used. Ringer's solution during pregnancy and lactation

Latin name: Ringer's solution
ATX code: B05BB01
Active substance: Calcium chloride,
potassium chloride and sodium chloride
Manufacturer: Kraspharma, Russia
Release from the pharmacy: On prescription
Storage conditions: t from 15 to 25 C
Best before date: 2 years.

Ringer's solution is a drug that is used to restore electrolyte balance in cases of shock, as well as in case of large blood loss.

Indications for use

• Collapse Development
• State of shock
• When metabolic acidosis occurs, accompanied by increased excretion of fluid from the body
• In case of injury, frostbite or burns
• If there is an imbalance of electrolytes that occurs due to diarrhea, prolonged vomiting, poisoning, or the development of an intestinal infection
• During the detection of intestinal fistula and intestinal obstruction
• With the development of peritonitis
• When performing plasmaphoresis for medicinal purposes.

The drug can also be used for inhalation to eliminate signs of rhinitis.

Composition and release form

The solution (1000 ml) contains sodium chloride, calcium chloride and potassium chloride, their mass fraction in the medicine is 8.6 g; 0.33 g; 0.3 g respectively. Ringer's solution also contains:

• Sodium hydroxide
• Prepared water
• Hydrochloric acid.

The colorless injection solution is dispensed in polyethylene bottles of 250 ml and 500 ml, there are 10 bottles inside the pack. The drug is also sold in glass bottles of 200 ml and 400 ml, the packaging can hold 1, 15 or 28 fl.

Medicinal properties

The INN of the drug does not match the trade name. Ringer's solution helps replenish excessive fluid loss, participates in the detoxification process, and helps normalize electrolyte balance. Quite quickly, but briefly, it increases the volume of blood circulating in the body due to its rapid release into the extravascular space.

Ringer's solution is capable of restoring blood volume for about 40 minutes; this must be taken into account during emergency medical care.

The detoxification effect of drugs is manifested due to the rapid dilution and increase in the volume of circulating blood, as a result of which the concentration of toxic substances in the blood decreases.

Ringer's solution: complete instructions for use

Price: from 19 to 1038 rubles.

Ringer's solution is indicated for administration exclusively intravenously (a dropper is placed or infused as a stream). The medicine is dripped at a rate of 60-80 drops. in 1 min.

The selection of daily dosage for children and adults is carried out individually. Ringer solution is used to set up infusions after consultation with a doctor.

Dose for children – 5-10 ml per 1 kg of weight. The medicine should be administered to the child at a rate not exceeding 60 drops. in 1 min. In severe cases, it is possible to increase the daily dose to 30 ml per 1 kg of weight.

For an adult, the dose is calculated as follows - 20 ml per 1 kg of body weight. The maximum dosage should not be more than 50 ml per 1 kg.

The duration of treatment depends on the nature of the disease, usually 3-5 days. Whether further treatment can be carried out should be checked with a doctor.

As part of complex therapy for rhinitis, it is recommended to carry out inhalation procedures with a nebulizer; for one application you will need to take 5 ml of medicine. It is recommended to carry out 2 inhalations per day. The duration of treatment depends on the observed therapeutic effect.

During pregnancy and breastfeeding, the drug should not be used, since experience in its use is limited.

Contraindications and precautions

The use of Ringer solution for infusion is not allowed for:

• Diagnosing edema of the membranes of the brain, as well as lung tissue
• Treatment of people with chronic pathologies of the renal system and cardiovascular system
• Hyperchloremia, signs of acidosis, hypervolemia, as well as in the case of hypernatremia
• The presence of increased susceptibility to the components of the solution.

When carrying out long-term treatment with these drugs, the level of electrolytes in the blood should be monitored, as well as the acid-base balance of the blood should be monitored.

Do not use Ringer's solution after the expiration date, if the integrity of the packaging is damaged, if the injection solution becomes cloudy or if a precipitate appears or changes its color.

Cross-drug interactions

Possible Na retention with combined use:

• Androgen-based products
• Corticotropin
• Anabolic drugs
• Ganglioblockers
• Estrogen-containing drugs
• Mineralocorticoids
• Drugs based on adrenal hormones
• Vasodilators.

If you drink cardiac glycosides at the same time, their toxic effects may increase.

If you take medications containing ACE inhibitors, diuretics, or potassium-based medications, signs of hyperkalemia may appear.

Side effects

The development of adverse symptoms is most often associated with an increase in prescribed doses and a change in the treatment regimen. Signs of allergies may appear, a decrease in plasma potassium levels, and the development of overhydration.

Overdose

There may be an increase in the frequency or severity of side symptoms. It is recommended to discontinue the medication and adjust the treatment regimen.

Analogues

Biosynthesis, Russia

Price from 20 to 45 rub.

Acesol, one of the analogues of Ringer's solution, is a plasma-substituting drug that exhibits antiplatelet and diuretic effects and helps eliminate intoxication. The main components are sodium and potassium chloride, sodium acetate. Produced in the form of an injection solution.

Pros:

• Low price (compared to other analogues of Ringer's solution)
• Prevents the development of metabolic acidosis
• Used to dehydrate the body.

Minuses:

• Contraindicated in chronic kidney pathologies
• May provoke the development of tachycardia, swelling
• Available only by prescription.

In case of intoxication of various etiologies, rehydrating agents are used to replenish the body with fluids and salts.

Loss of more than 20% of water is fatal. Urgent use of this series of medications saves you from mortal danger. A representative of this group is Ringer's solution. The aqueous composition contains selected components corresponding to plasma and formed elements. The route of administration is orally. If there is severe loss of electrolyte balance, intravenous injection is necessary. For proper therapy, we advise you to carefully read the instructions for ringer solution.

pharmachologic effect

Ringer's solution:
prevents dehydration;
compensates for the loss of micro and macroelements.
normalizes heart function;
binds toxins;
weakens the destructive effect of pathogenic microflora;
prevents the occurrence of thrombosis;
enhances urine output;
improves blood circulation;
restores the liver.

Pharmacodynamics

The speed of absorption into the blood depends on the route of ingestion. With drip administration, the pathological condition decreases faster. The blood circulation is not overloaded. The complex substance does not change the osmotic pressure of the blood. It leaves the bloodstream within ten minutes. Excreted in urine. Compatible with other medications.

Compound

The mixture contains active ingredients: potassium, calcium and sodium salts.
Potassium chloride
Intracellular ion. Stimulates the release of adrenaline from the adrenal glands. An increase in the concentration of the element is accompanied by a decrease in excitability and conductivity. Large doses have a depressing effect on the cardiac cycle, reducing its frequency. Increases adrenaline production and synthesizes ATP. With a deficiency, the brain is poorly supplied and concentration decreases.
It is quickly absorbed and intensively excreted by the kidneys. It is used for problems with blood circulation, diarrhea, toxic infections, and after surgery.
Calcium chloride
Helps in the transmission of nerve impulses, regulates the secretion of hormones, promotes blood clotting. A necessary participant in the formation of bone tissue. Disturbs transcapillary metabolism, eliminates allergic reactions and inflammatory processes. Used for myocardial dysfunction, bleeding, toxic liver damage, poisoning. Used during and after surgery.
Sodium chloride
Provides osmotic stability, regulates the supply and removal of water in the cell. Reducing the amount of sodium and chlorine leads to changes in the functioning of the nervous system. With a deficiency, the work of the myocardium and smooth muscles changes. The water structure increases blood volume and promotes ionic stability. Improves blood circulation, causes antitoxic effect. Acts as a solvent for other drugs. Used to increase blood pressure during bleeding. Plays a supporting role in cerebral edema. Neutralizes silver nitrate poisons.

Due to the complex content of macroelements, Ringer's solution is indicated for pathological conditions of any etiology.

Usage

The drug is used in the following conditions:
toxic dyspepsia;
burns;
vomit;
blood loss;
collapse;
viral infections;
poisoning;
frostbite;
food poisoning;
severe diarrhea;
dehydration;
peritonitis;
intestinal obstruction.

Precautionary measures

Excessive intake of physiological fluid leads to pulmonary edema and deterioration of heart function. Then reduce the volume or stop taking it.

Contraindications

:
irreversible changes in the functioning of the heart;
swelling;
pathology of excretory organs.

Side effects
Undesirable complications are expressed in excess water content, decreased potassium ions, and allergies.

Instructions for use

Dosage for animals
When prescribing a rehydrating agent, the degree of dehydration, pathological diagnosis, age and weight are taken into account.
The average therapeutic dose per day is 40 ml/kg.

Ringer–Locke solution
The medicine contains additional components: sodium bicarbonate + glucose.

Ringer-Locke solution indications for use

In severe forms of the disease or acute pathologies, the composition is administered intravenously. In this case, the substance acts immediately. When administered intramuscularly, the results appear within 20 minutes. With subcutaneous injection, resorption is slow. Do not pour in the cold solution. Temperature – 36°C. Before injecting Ringer's solution, inspect the contents of the bottle. Impurities, suspended particles, and sediment are not allowed.

Injections for cats at home (eng)

Ringer's solution is indicated for use in cats.

Animals are injected with a medicinal mixture intravenously or subcutaneously. Subcutaneous injections are administered in short portions.
The medicine is injected slowly and easily. If there is resistance, pull out the needle and insert it into another place. Otherwise, the injection will be intramuscular, which is not recommended. The swelling on the withers will resolve quickly.
With severe dehydration, death occurs quickly. Injections should be made every 4 hours. If you experience frequent vomiting and diarrhea, contact your veterinarian immediately.

Price

The cost of the drug is determined by the size of the bottle.
The average price in pharmacies is 25 - 45 rubles.

Storage conditions

Ringer's solution should be:
do not expose to direct rays of the sun;
keep in pharmaceutical packaging;
store at a temperature not exceeding 26°C and not falling below 14°C;
ensure that the drug is not available to children.

Best before date

Use the drug for 3 years. Do not use stitched ones.

How to install the system for a cat at home?

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general characteristics:

Basic physical and chemical properties: transparent, colorless and odorless liquid, salty taste. Theoretical osmolarity - 309 mOsmol/l;

Compound: 100 ml of solution contains sodium chloride 0.86 g, potassium chloride 0.03 g, calcium chloride 0.048 g;

excipients: water for injection.

Release form. Solution for infusion.

Pharmacotherapeutic group. Solutions for intravenous administration. Electrolytes.

ATS code B05B B01.

Pharmacological properties.

Pharmacodynamics. Ringer's solution normalizes the water-salt and acid-base balance and eliminates fluid deficiency in the human body, which develops during dehydration or due to the accumulation of extracellular fluid in areas of extensive burns and injuries, during operations on the abdominal organs, and peritonitis. Ringer's solution improves the rheological properties of blood and tissue perfusion, increases the effectiveness of blood transfusion measures in cases of massive blood loss and severe forms of shock.

It also has a disinfecting effect due to a short-term increase in fluid volume, a decrease in the concentration of toxic products in the blood, and activation of diuresis.

Pharmacokinetics. It is quickly eliminated from the vascular system. The drug is retained in the vascular bed for 30-40 minutes and very quickly passes into the interstitial sector and intracellularly. After an hour, only about half of the injected solution remains in the vessels. Very quickly, salts and liquid begin to be excreted by the kidneys, increasing diuresis.

Indications for use. Iso- and hypotonic dehydration and metabolic acidosis as a result of prolonged diarrhea, uncontrollable vomiting, acute massive blood loss, shock, extensive burns, severe postoperative period, poisoning of various etiologies.

Ringer's solution is also used externally to wash wounds.

Directions for use and doses. Ringer's solution is administered intravenously to adults at a rate of 4-10 mL/year in a volume of 50 ml to 3 liters. The drug is prescribed rectally for adults, 75-100 ml. Children under 6 years of age are prescribed at the rate of 5 mlkg per year in a volume of 50 ml to 500 ml. For children from 6 to 12 years of age, the dose of the drug is about half the dose for adults. For children over 12 years of age, the dose is the same as for adults.

Side effect. Using Ringer's solution in large quantities can lead to the development of chloride acidosis and overhydration.

Contraindications. Intravenous administration of Ringer's solution is contraindicated in thrombophlebitis, conditions with increased blood clotting, severe impairment of renal excretory function, and decompensated heart defects. The drug should not be administered in conditions where its administration can cause swelling of the brain and lungs, with hyperchloremia, hypernatremia, hyperhydration, metabolic alkalosis.

Overdose. With a significant overdose, phenomena of alkalosis and overhydration may be observed. In this case, the administration of the drug is stopped immediately. Symptomatic therapy is carried out.

Features of application. With long-term use, especially in large volumes, monitor the content of electrolytes in plasma, urine, and diuresis.

Interaction with other drugs. The drug cannot be mixed with phosphate and carbonate solutions. The drug can be used as a carrier solvent for other drugs.

Storage conditions. Store at a temperature of 0 to 25 ºС out of the reach of children.

Shelf life – 2 years.

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Date of publication: 03/30/17

Ringer's solution is a well-known medicine for restoring electrolyte balance. This drug promotes detoxification and replenishes fluid loss.

The drug replenishes fluid loss, promotes detoxification, and restores the electrolyte balance of the body. Effectively, but briefly, it replenishes the volume of circulating blood (CBV), since it quickly enters the extravascular space. The effect of Ringer's solution to restore bcc lasts no more than 30-40 minutes, which must be taken into account when providing emergency care.

In this article we will look at why doctors prescribe Ringer's solution, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Ringer's solution, leave your feedback in the comments.

Composition and release form

Clinical and pharmacological group: drug for rehydration and detoxification for parenteral use.

One milliliter of Ringer's solution contains 8.6 grams of sodium chloride, 0.3 g of potassium chloride, 0.33 g of calcium chloride. The drug also contains: hydrochloric acid, sodium hydroxide, water.

Sold in plastic bottles with a capacity of 500 ml (10 pieces); bottles of 200 or 400 ml; containers with a capacity of 250 ml (40 pieces) or 500 ml (20 pieces); in containers of 100 ml, 1 or 50 containers per package; in one liter containers.

What is Ringer's solution used for?

Using the solution, you can urgently replenish fluid loss in the body. Medicine uses a remedy to restore the electrolyte balance of the body. Among other things, Ringer's solution can replenish the volume of blood circulating in the body, which in some cases can really save lives.

Ringer's acetate solution is prescribed for:

• large blood losses;
• shock states;
• hypovolemia;
• dehydration of various origins;
• burns;
• frostbite;
• diarrhea;
• peritonitis;
• electrical injuries;
• poisoning accompanied by vomiting;
• dysentery and some infectious diseases.

Many doctors use this product to dilute concentrated electrolyte solutions.

pharmachologic effect

Ringer's solution is a source of water and electrolytes. Sodium, the main cation of extracellular fluid, takes part in the control of water distribution, water balance, and osmotic pressure of body fluids. Sodium is also associated with chlorine and bicarbonate in regulating the acid-base balance of body fluids.

Instructions for use

This medicinal substance is intended for parenteral administration. In accordance with the instructions, Ringer's solution is administered intravenously by drip, setting an average rate of 60-80 drops per minute (250 ml/h), or by stream (during emergency rehydration assistance).

1. The daily dose for children is set at a rate of 5 to 10 ml per 1 kg of body weight, the rate of administration is from 30 to 60 drops per minute, for emergency indications the dosage can be increased to 20-30 ml/kg.
2. The daily dose for adults is 10-20 ml per 1 kg of body weight, for emergency indications it can be increased to 30-50 ml/kg.
3. In general, the daily dose is from 2 to 6% of body weight.

The course of treatment is determined individually, on average it lasts from 3 to 5 days.

Contraindications for use

The drug is not administered to patients diagnosed with:

• individual intolerance;
• excess sodium and (or) chlorine in the blood;
• cerebral edema;
• significant chronic heart failure;
• severe chronic functional kidney failure;
• hypervolemia (excess fluid).

An intravenous infusion of Ringer's Solution should not be administered if the patient is currently undergoing hormonal therapy using glucocorticosteroid drugs. Particular care should be taken if the victim has arterial hypertension.

Side effects

The instructions for the drug indicate that possible side effects of Ringer's solution may include:

1. Hyperkalemia (increased serum potassium concentration over 5 mmol/l).
2. Overhydration (excessive water content in the body).
3. Allergic reactions.

Overdose

In case of overdose, an imbalance of water and electrolytes (hypervolemia, hypernatremia, hyperkalemia, hypercalcemia, hyperchloremia) and acid-base balance may occur. In most cases, it is enough to interrupt the administration of the solution.

Pregnancy and lactation

During pregnancy, it is used in cases where the expected benefit to the mother outweighs the possible risk to the fetus. You should refrain from breastfeeding while using the drug due to the lack of relevant clinical data.

special instructions

In the case of rapid administration of a large volume, it is necessary to monitor the CBS and the level of electrolytes. A change in blood pH (acidification) leads to a redistribution of K+ (a decrease in pH leads to an increase in the K+ content in the blood serum).

Analogues

Darrow, Phys. solution, Acesol, Disol, Ionosteril, Ringer-Locke solution, Trisol, Chlosol.

Attention: the use of analogues must be agreed with the attending physician.

Prices

Average price of Ringer's solution, vial. 400ml in pharmacies (Moscow) 30 rubles.

Storage conditions

The drug must be stored in a dark, cool place (15 to 25 degrees). At the same time, if the medicine was frozen during storage, then it can be used provided that the appearance of the solution has not changed (has not become cloudy, there are no flakes or sediment), and the packaging is not damaged. Keep away from children.

Conditions for dispensing from pharmacies

Prescription release. Approved for use only in medical institutions.

Photo of the drug

Latin name: Ringer's solution

ATX code: B05BB01

Active substance: Calcium chloride + Potassium chloride + Sodium chloride

Manufacturer: Hemofarm (Serbia), Mosfarm, Biosintez, Sakhamedprom Gul, Medsintez Plant, Ozon Pharm, Eskom NPK, Kraspharma (Russia)

Description is valid on: 16.10.17

Ringer's solution is a medicine for restoring electrolytic balance. WITH

Active substance

Sodium chloride solution is complex (Compound solution of sodium chloride).

Release form and composition

Available in the form of a solution for infusion. It is a clear, colorless liquid. Packaged in 500 ml plastic bottles with built-in dropper holders.

Indications for use

• thermal injuries (frostbite, burns);
• shock of various etiologies;
• collapse;
• electrical injury;
• intestinal obstruction;
• acute peritonitis;
• poisoning of various origins, accompanied by persistent vomiting;
• intestinal fistula;
• therapeutic plasmapheresis;
• acute intestinal infections characterized by severe diarrhea syndrome;
• alkalosis of metabolic etiology, accompanied by dehydration.

Contraindications

• cerebral edema;
• hypernatremia (high percentage of sodium in blood plasma);
• pulmonary edema;
• hyperchloremia (high concentrations of chlorine in the blood plasma);
• acidosis;
• renal failure;
• taking glucocorticosteroids;
• heart failure (stage of decompensation);
• individual intolerance to the drug.

Use during pregnancy and breastfeeding is only possible in emergency cases, as there is no data on its safety in these conditions.

Instructions for use Ringer's solution (method and dosage)

Intended exclusively for parenteral administration. It is administered intravenously by drip (the rate of administration of the solution varies from 60 to 80 drops per minute) or by stream (emergency assistance for rehydration).

• The average daily dosage for children is set at the rate of 5 - 10 ml per 1 kg of body weight. The rate of drug administration ranges from 30 to 60 drops per minute. In severe cases, the dose can be increased to 20 - 30 ml per 1 kg of weight.
• The daily dose for adults is 5 – 20 ml per 1 kg of body weight. In emergency situations, the dosage is increased to 30–50 ml per 1 kg of weight.

The duration of therapy is determined by the attending physician individually (usually from 3 to 5 days).

Side effects

Ringer's solution may cause the following side effects:

• allergies (skin itching, rashes, urticaria, etc.);
• overhydration;
• hypokalemia (decreased potassium concentration in blood plasma).

To eliminate side effects, it is enough to reduce the dose of the solution. If an allergic reaction occurs, it is necessary to immediately stop administering the drug and carry out desensitizing therapy.

Overdose

In case of an overdose of Ringer's Solution, an imbalance of water and electrolytes and acid-base balance may occur.

To eliminate the symptoms of an overdose, it is enough to interrupt the administration of the drug.

Analogues

Analogues by ATX code: Addamel N, Acesol, Disol, Quintasol, Methusol.

Do not decide to change the drug on your own; consult your doctor.

pharmachologic effect

• Ringer's solution promotes detoxification, replenishes fluid loss, and also restores electrolytic balance in various states of shock and blood loss. The drug replenishes the BCC (circulating blood volume).
• The agent very quickly enters the extravascular space, so it should be borne in mind that the latter effect is short-lived, lasting from 30 to 40 minutes. The detoxification effect of the drug is based on the effect of increasing the volume and thinning of the blood, which leads to a decrease in the concentration of toxic substances in it.

special instructions

In the case of rapid administration of a large volume, it is necessary to monitor the acid-base status and electrolyte concentration. A change in blood pH leads to a redistribution of K+ (a decrease in pH leads to an increase in the content of K+ ions in the blood serum). Freezing the drug, provided the container remains sealed, is not a contraindication to the use of the drug. If the contents of the container become cloudy, do not use. When combining with other drugs, it is necessary to visually monitor compatibility.

During pregnancy and breastfeeding

During pregnancy, it is used in cases where the expected benefit to the mother outweighs the possible risk to the fetus. You should refrain from breastfeeding during the period of use due to the lack of relevant clinical data.

In childhood

Daily dose for children: 5 – 10 ml/kg, rate of administration: 30 – 60 drops/min; for shock dehydration, 20 – 30 ml/kg is initially administered.

In old age

Information is absent.

For impaired renal function

Contraindicated in chronic renal failure.

Drug interactions

• It is possible to increase sodium retention in the body while taking the following medications: NSAIDs, androgens, anabolic hormones, estrogens, corticotropin, mineralocorticoids, vasodilators or ganglion blockers.
• When taken with potassium-sparing diuretics, ACE inhibitors and potassium supplements, the risk of developing hyperkalemia increases.
• In combination with cardiac glycosides, the likelihood of their toxic effects increases.