Instructions for use of Panadol. Panadol® soluble tablets Panadol for temperature

Suppresses PG synthesis in the central nervous system, reduces the excitability of the hypothalamic thermoregulation center, and increases heat transfer. Quickly and almost completely absorbed from the gastrointestinal tract. Concentration in plasma reaches its peak after 30-60 minutes, T1/2 plasma - 1-4 hours. Metabolized in the liver. Excreted in the urine, mainly in the form of esters with glucuronic and sulfuric acids; less than 5% is excreted unchanged. It has analgesic and antipyretic properties; the latter manifest themselves in conditions of febrile syndrome of any origin.

Indications for use of the drug Panadol for adults

Pain of mild to moderate intensity (headache, migraine, back pain, arthralgia, myalgia, neuralgia, toothache, menalgia). Feverish syndrome with colds.

Contraindications to the use of Panadol for adults

Hypersensitivity.

Use of the drug Panadol for adults

Panadol is prescribed orally for adults in a single dose of 500 mg (maximum single dose - 1 g). The frequency of administration is up to 4 times a day. The maximum daily dose is 4 g. The maximum duration of treatment is 5-7 days.
Single doses for children aged 6-12 years - 240-480 mg; 6-12 years - 240 mg; 1-6 years - 120-240 mg; from 3 months to 1 year - 24-120 mg. The frequency of administration of Panadol is 4 times a day; the interval between each dose is at least 4 hours. The maximum duration of treatment is 3 days.
When taking Panadol tablets or capsules orally, take them with water.

Side effects of the drug Panadol for adults

Allergic reactions in the form of skin rashes.

Overdose of Panadol for adults, symptoms and treatment

Symptoms of overdose in the first 24 hours are pallor, nausea, vomiting and pain in the abdominal area. 12-48 hours after administration, kidney and liver damage may occur with the development of liver failure (encephalopathy, coma, death). Liver damage is possible when taking 10 g or more (in adults). Acute renal failure with tubular necrosis can develop in the absence of serious liver damage. Other manifestations of overdose are cardiac arrhythmias and pancreatitis.

Special instructions for the use of Panadol for adults

Use with caution in patients with impaired liver or kidney function. The risk of hepatotoxicity increases with the simultaneous administration of barbiturates, diphenine, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes, as well as with the simultaneous administration of metoclopramide, domperidone and cholestyramine. It is recommended to avoid long-term and regular use of paracetamol as an anesthetic while taking anticoagulants .

List of pharmacies where you can buy Panadol for adults:

Saint Petersburg

K08.8 Other specified changes in the teeth and their supporting apparatus M79.1 Myalgia M79.2 Neuralgia and neuritis, unspecified N94.4 Primary dysmenorrhea N94.5 Secondary dysmenorrhea R07 Pain in the throat and chest R50 Fever of unknown origin R51 Headache

Pharmacological group

Analgesic-antipyretic

Pharmacological action

Analgesic-antipyretic. Has an analgesic and antipyretic effect. Blocks COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation.

The anti-inflammatory effect is practically absent. Does not cause irritation to the mucous membranes of the stomach and intestines. It has no effect on water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics

Suction and distribution

Absorption is high, C max is reached after 0.5-2 hours and is 5-20 μg/ml.

Communication with plasma proteins - 15%. Penetrates through the BBB. Less than 1% of the dose of paracetamol taken by a nursing mother passes into breast milk. The therapeutically effective concentration of paracetamol in plasma is achieved when administered at a dose of 10-15 mg/kg.

Metabolism and excretion

Metabolized in the liver (90-95%): 80% enters into conjugation reactions with glucuronic acid and sulfates to form inactive metabolites; 17% undergoes hydroxylation to form 8 active metabolites, which conjugate with glutathione to form inactive metabolites. With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis. The CYP 2E1 isoenzyme is also involved in the metabolism of the drug.

T1/2 - 1-4 hours. Excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

Pharmacokinetics in special clinical situations

In elderly patients, drug clearance decreases and T1/2 increases.

Symptomatic therapy:

Pain syndrome: headache, migraine, toothache, sore throat, lower back pain, muscle pain, painful menstruation;

Feverish syndrome (as an antipyretic): increased body temperature due to colds and flu.

The drug is intended to reduce pain at the time of use and does not affect the progression of the disease.

Children under 6 years of age;

Hypersensitivity to the components of the drug.

WITH caution The drug should be used for renal and liver failure, benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, glucose-6-phosphate dehydrogenase deficiency, alcoholic liver damage, alcoholism, in old age, during pregnancy and lactation.

Allergic reactions: sometimes - skin rashes, itching, Quincke's edema.

From the hematopoietic system: rarely - anemia, thrombocytopenia, methemoglobinemia.

From the urinary system: with long-term use in high doses - renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis.

Overdose

The drug should be taken only in recommended doses. If you exceed the recommended dose, you should seek immediate medical attention, even if you feel well, as there is a risk of delayed serious liver damage.

Liver damage in adults is possible when taking ≥ 10 g of paracetamol. Taking ≥ 5 g of paracetamol may cause liver damage in patients with the following risk factors:

Long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John's wort or other drugs that stimulate liver enzymes;

Regular consumption of alcohol in excess quantities;

Possibly having glutathione deficiency (due to malnutrition, cystic fibrosis, HIV infection, starvation and exhaustion).

Symptoms Acute paracetamol poisoning includes nausea, vomiting, stomach pain, sweating, and pale skin. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of liver enzymes). In severe cases of overdose, liver failure develops, acute renal failure with tubular necrosis (including in the absence of severe liver damage), arrhythmia, pancreatitis, encephalopathy and coma may develop. Hepatotoxic effects in adults occur when taking ≥ 10 g of paracetamol.

Treatment: Stop using the drug and consult a doctor immediately. It is recommended to lavage the stomach and take enterosorbents (activated carbon, polyphepane); administration of SH-group donors and precursors for the synthesis of glutathione - methionine 8-9 hours after an overdose and N-acetylcysteine - after 12 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration. Treatment of patients with severe liver dysfunction 24 hours after taking paracetamol should be carried out in conjunction with specialists from a poison control center or specialized liver disease department.

Special instructions

With long-term use in high doses, monitoring of the blood picture is necessary.

The drug should be used with caution and only under the supervision of a physician for liver or kidney diseases, while taking antiemetic drugs (metoclopramide, domperidone), as well as drugs that lower blood cholesterol (cholestyramine).

In case of daily need for analgesics while taking anticoagulants, paracetamol can be taken occasionally.

When conducting tests to determine uric acid and blood glucose levels, you should warn your doctor about taking Panadol.

To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption.

For renal failure

WITH caution The drug should be used for renal failure.

In case of liver dysfunction

WITH caution The drug should be used for liver failure.

Elderly

WITH caution the drug should be used in old age.

Use during pregnancy and breastfeeding

The drug should be used with caution and only under the supervision of a physician during pregnancy and lactation.

Drug interactions

Long-term combined use of paracetamol and other NSAIDs increases the risk of developing “analgesic” nephropathy and renal papillary necrosis, and the onset of end-stage renal failure.

Simultaneous long-term administration of paracetamol in high doses and salicylates increases the risk of developing kidney or bladder cancer.

Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

The drug, when taken for a long time, enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.

Inducers of microsomal oxidation enzymes in the liver (barbiturates, phenytoin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxicity in overdoses.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.

Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol.

Ethanol, when used simultaneously with paracetamol, contributes to the development of acute pancreatitis.

The drug may reduce the activity of uricosuric drugs.

Adults (including elderly) the drug is prescribed at 500 mg-1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours.

Children aged 6-9 years prescribed 1/2 tablet. 3-4 times/day, if necessary. The interval between doses is at least 4 hours. The maximum single dose for children 6-9 years old is 1/2 tablet. (250 mg), maximum daily dose - 2 tablets. (1 g).

Children aged 9-12 years 1 tablet is prescribed. up to 4 times/day, if necessary. The interval between doses is at least 4 hours, a single dose (1 tablet) can be taken no more than 4 times (4 tablets) within 24 hours.

The drug is not recommended for use for more than 5 days as an analgesic and for more than 3 days as an antipyretic without a doctor’s prescription and supervision. Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Storage conditions and shelf life

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 5 years.

Release from pharmacies

The drug is approved for use as an over-the-counter product.

CHILDREN'S PANADOL

Registration number:

P No. 011292/01

Trade patent name: CHILDREN'S PANADOL

International nonproprietary name:

paracetamol

Dosage form:

suspension for oral administration

Compound. Each 5 ml of suspension contains: active ingredient - paracetamol 120 mg; Inactive Ingredients: Malic Acid, Xantham Gum, Glucose Syrup Hydrogenate (Maltitol), Sorbitol, Citric Acid, Nipasept Sodium, Strawberry Flavor, Azorubine, Water.

Children's Panadol does not contain sugar, alcohol and acetylsalicylic acid.

Description:
Pink viscous liquid with a strawberry odor, containing crystals.

Pharmacotherapeutic group:

Analgesic non-narcotic drug.

ATX code: N02BE01.

Pharmacological properties:

Pharmacodynamics.
The drug has analgesic and antipyretic properties. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. The anti-inflammatory effect is practically absent. It does not affect the condition of the gastrointestinal mucosa and water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics.
Absorption is high - Panadol is quickly and almost completely absorbed from the gastrointestinal tract. Plasma protein binding is about 15%. Peak plasma concentrations are reached after 30-60 minutes. The distribution of paracetamol in body fluids is relatively even.

Metabolized primarily in the liver with the formation of several metabolites. In newborns in the first two days of life and in children 3-10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children 12 years of age and older, it is conjugated glucuronide. Part of the drug (approximately 17%) undergoes hydroxylation to form active metabolites that are conjugated with glutathione. With a lack of glutathione, these metabolites of paracetamol can block the enzyme systems of hepatocytes and cause their necrosis.

The half-life when taking a therapeutic dose ranges from 2-3 hours. When taking therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is released after conjugation in the liver. No more than 3% of the received dose of paracetamol is excreted unchanged.

Indications for use.
Used in children from 3 months to 12 years as:

antipyretic - to reduce elevated body temperature against the background of colds, flu and childhood infectious diseases (chicken pox, mumps, measles, rubella, scarlet fever, etc.)
analgesic - for toothache, including teething, headache, earache, otitis media and sore throat.

For children 2-3 months of age, a single dose is possible to reduce fever after vaccination. If the temperature does not decrease, consult a doctor.

Contraindications:

hypersensitivity to paracetamol or any other ingredient of the drug;
severe liver or kidney dysfunction;
neonatal period;

Precautions:
Use with caution in case of impaired liver function (including Gilbert's syndrome), kidney function, genetic absence of the enzyme glucose-6-phosphate dehydrogenase, severe blood diseases (severe anemia, leukopenia, thrombocytopenia). In such cases, you should consult your doctor before taking the drug. The drug should not be taken simultaneously with other paracetamol-containing drugs.

Directions for use and dosage:

The drug is taken orally.

The contents of the bottle should be shaken well before use. The measuring syringe placed inside the package allows you to dose the drug correctly and rationally.

The dose of the drug depends on the age and body weight of the child.

For children over 3 months of age, a single dose is 15 mg/kg body weight, 3-4 times a day, the maximum daily dose is no more than 60 mg/kg body weight. If necessary, give your child the recommended dose every 4 to 6 hours, but no more than 4 doses in 24 hours.

In all other cases, before taking Children's Panadol, you must consult a doctor.

Body weight (kg)	Age	Dose
		One-time		Maximum daily
		ml	mg	ml	mg
4,5-6	2nd month of life	Only on doctor's orders
6-8	3 - 6 months	4.0	96	16	384
8-10	6-12 months	5.0	120	20	480
10-13	1 - 2 years	7.0	168	28	672
13-15	2 - 3 years	9.0	216	36	864
15-21	3 - 6 years	10.0	240	40	960
21 -29	6 - 9 years	14.0	336	56	1344
29-42	9-12 years	20.0	480	80	1920

Duration of admission without consulting a doctor:

To reduce the temperature - no more than 3 days.
For pain relief - no more than 5 days.

Side effects:
At recommended doses, paracetamol rarely has side effects. Sometimes nausea, vomiting, pain in the stomach, allergic reactions (skin rash, itching, urticaria, Quincke's edema) are possible. Rarely - anemia, thrombocytopenia, leukopenia.

If any adverse reactions occur, stop taking the drug immediately and consult a doctor.

Overdose:

Signs of acute paracetamol poisoning are nausea, vomiting, stomach pain, sweating, and pale skin. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of liver enzymes). In severe cases, liver failure, encephalopathy and coma develop. With long-term use in excess of the recommended dose, hepatotoxic and nephrotoxic effects (renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis) may be observed.

Treatment: Stop using the drug and consult a doctor immediately.
It is recommended to lavage the stomach and take enterosorbents (activated carbon, polyphepane). A specific antidote for paracetamol poisoning is acetylcysteine.

In case of accidental overdose, seek immediate medical attention, even if the child feels well.

Interaction with other drugs:

When using Children's Panadol together with barbiturates, diphenin, anticonvulsants, rifampicin, butadione, the risk of hepatotoxicity may increase.

When taken simultaneously with chloramphenicol (chloramphenicol), the toxicity of the latter may increase. The anticoagulant effect of warfarin and other coumarin derivatives may be enhanced by long-term regular use of paracetamol, which increases the risk of bleeding.

Special instructions:

Children from 2 to 3 months and children born prematurely can be given Children's Panadol only as prescribed by a doctor. When performing tests to determine uric acid and blood sugar levels, tell your doctor about the use of Children's Panadol.

Release form:

Suspension 120 mg/5 ml in dark glass bottles of 100, 300 and 1000 ml. Bottles of 100 and 300 ml along with a measuring syringe and instructions for use are packed in a cardboard box

Storage conditions:

At temperatures not exceeding 30° C. Protect from light. Do not freeze. Keep out of the reach of children.

Best before date:

3 years. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies:

Over the counter.

Manufacturer:

GlaxoSmithKline Consumer Healthcare, produced by Glaxo Wellcome Production, France.
Glaxo Wellcome Production, 440 Avenue du General de Gaulle, 14200 Herouville Saint Clair, France
Glaxo Wellcome Production, 440 Avenue Generale de Hull, 14200 Hérouville Saint-Clair, France
Representative address: 119180 Moscow, Yakimanskaya embankment. 2 JSC GlaxoSmithKline Healthcare

Panadol is a drug belonging to the group of non-steroidal anti-inflammatory drugs. Panadol is used to reduce elevated body temperature. In addition, this remedy has an analgesic effect.

The anti-inflammatory effect of the drug is weak due to the fact that paracetamol is inactivated by cellular peroxidases. The analgesic and antipyretic effect of the drug is achieved by reducing the amount of prostaglandins in the central nervous system.

In this article we will look at why doctors prescribe Panadol, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Panadol can be read in the comments.

Composition and release form

Panadol is available in tablet form: soluble Panadol tablets and film-coated tablets.

One tablet contains 500 mg of paracetamol.
Additional components: citric acid, sodium bicarbonate, sodium saccharinate, sorbitol, sodium carbonate, povidone, sodium lauryl sulfate, dimethicone.

Clinical and pharmacological group: analgesic-antipyretic.

What does Panadol help with?

The drug Panadol is used for symptomatic therapy:

Pain syndrome: painful menstruation, muscle pain, lower back pain, sore throat, toothache, migraine, headache;
Feverish syndrome: increased body temperature during colds and flu (as an antipyretic).

The drug does not affect the progression of the disease and is intended to reduce pain and fever at the time of use.

Pharmacological action

Analgesic-antipyretic. Has an analgesic and antipyretic effect. Blocks COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation. The anti-inflammatory effect is practically absent. Does not cause irritation to the mucous membranes of the stomach and intestines. It has no effect on water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.

Instructions for use

Approximate use and dosage of Panadol in tablet form:

For adults (including the elderly), the drug is prescribed 500 mg-1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours.
Children aged 6-9 years are prescribed 1/2 tablet. 3-4 times/day, if necessary. The interval between doses is at least 4 hours. The maximum single dose for children 6-9 years old is 1/2 tablet. (250 mg), maximum daily dose – 2 tablets. (1 g).
Children aged 9-12 years are prescribed 1 tablet. up to 4 times/day, if necessary. The interval between doses is at least 4 hours, a single dose (1 tablet) can be taken no more than 4 times (4 tablets) within 24 hours.

Approximate scheme of use and dosage of children's Panadol in the form of a suspension:

2–3 months – individual dosage is prescribed exclusively by the attending physician;
3–6 months – give the baby 4 ml, the maximum permissible daily dose is 16 ml;
from 6 months to 1 year – 5 ml up to four times a day;
from one to two years – 7 ml, per day up to 28 ml;
from one to two years – 9 ml, it is allowed to use up to 36 ml per day;
from three years to six years old – 10 ml, the maximum allowed to give a baby is 40 ml;
from six to nine years - 14 ml, you can give the baby 56 ml per day;
from nine to twelve years - 20 ml, 80 ml can be taken daily.

Contraindications

It is necessary to refuse completely:

until the child is 3 months old;
with severe disorders of the kidneys and liver;
in case of personal intolerance to the components that make up Panadol.

Give with caution:

with minor deviations in the functioning of the kidneys and liver;
in the absence of the enzyme glucose-6-phosphate dehydrogenase;
with existing blood pathologies - severe anemia, thrombocytopenia and leukopenia.

For babies from 2 to 3 months and premature babies, a single dose is allowed only with the permission of the pediatrician.

Side effects

The drug is usually well tolerated by patients, but in some cases the following side effects may develop:

Metabolic processes: lowering blood glucose levels.
Urinary system: kidney inflammation.
Skin lesions: skin necrosis.
Respiratory system: bronchospasm.
Digestive system: vomiting, increased activity of liver enzymes, nausea, stomach pain.
Hypersensitivity reactions: skin rash, itching, urticaria, Stevens-Johnson syndrome, Lyell's syndrome, Quincke's edema, anaphylactic shock.
Hematopoietic system: anemia, pancytopenia, agranulocytosis, thrombocytopenia, methemoglobinemia.
Laboratory tests: changes in uric acid and blood sugar levels.

Analogues

The following drugs are analogues of Panadol based on the active substance:

Apap;
Daleron;
Ifimol;
Calpol;
Xumapar;
Paracetamol;
Perfalgan;
Passer;
Strimol;
Flutabs;
Cefekon D;
Efferalgan.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of PANADOL tablets in pharmacies (Moscow) is 45 rubles. Children's suspension costs 90 rubles.

Conditions for dispensing from pharmacies

The drug is approved for use as an over-the-counter product.

Cost from 29.00 rub. (excluding drug release forms)

Packaging Effervescent tablets

Pharmacological action Has analgesic and antipyretic properties; the latter manifest themselves in conditions of febrile syndrome of any origin.

List of analogues of "Panadol"

* - the list and cost are formed without taking into account the forms of release of the drug

Indications for use

Pain of mild to moderate intensity (headache, migraine, back pain, arthralgia, myalgia, neuralgia, toothache, menalgia). Feverish syndrome with colds.

Release form

Soluble tablets 500 mg
strip 2 pack cardboard 6
Soluble tablets 500 mg
strip 4 cardboard pack 6
Soluble tablets 500 mg
strip 2 pack cardboard 12

Pharmacodynamics of the drug A non-narcotic analgesic, it blocks COX1 and COX2 mainly in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of anti-inflammatory effect. The absence of a blocking effect on the synthesis of Pg in peripheral tissues determines the absence of a negative effect on water-salt metabolism (retention of Na+ and water) and the mucous membrane of the gastrointestinal tract.

Pharmacokinetics of the drug Quickly and almost completely absorbed from the gastrointestinal tract. Concentration in plasma reaches a peak after 30–60 minutes, T1/2 plasma - 1–4 hours. Metabolized in the liver. Excreted in the urine, mainly in the form of esters with glucuronic and sulfuric acids; less than 5% is excreted unchanged.

Use during pregnancy With caution.

Contraindications for use

Hypersensitivity, neonatal period (up to 1 month). With caution. Renal and liver failure, benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, alcoholism, pregnancy, lactation, old age, early infancy (up to 3 months), glucose-6-phosphate dehydrogenase deficiency
diabetes mellitus

Side effects From the skin: itching, rash on the skin and mucous membranes (usually erythematous, urticaria), angioedema, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). From the side of the central nervous system (usually develops when taking high doses): dizziness, psychomotor agitation and disorientation. From the digestive system: nausea, epigastric pain, increased activity of liver enzymes, usually without the development of jaundice, hepatonecrosis (dose-dependent effect).

From the endocrine system: hypoglycemia, up to hypoglycemic coma.

From the hematopoietic organs: anemia, sulfhemoglobinemia and methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency). With long-term use in large doses - aplastic anemia, pancytopenia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia. From the urinary system: (when taking large doses) - nephrotoxicity (renal colic, interstitial nephritis, papillary necrosis).

Dosage Inside, adults - 2 tablets. up to 4 times a day with an interval between doses of at least 4 hours (maximum daily dose - 8 tablets), children from 6 to 12 years old - 1/2–1 tablet. up to 4 times a day with an interval between doses of at least 4 hours (maximum daily dose - 4 tablets).

Soluble tablets are dissolved in 1/2 glass of water before use.

Overdose Symptoms (acute overdose develops 6-14 hours after taking paracetamol, chronic - 2-4 days after exceeding the dose) of acute overdose: dysfunction of the gastrointestinal tract (diarrhea, loss of appetite, nausea and vomiting, abdominal discomfort and/or pain in the abdomen), increased sweating. Symptoms of chronic overdose: a hepatotoxic effect develops, characterized by general symptoms (pain, weakness, adynamia, increased sweating) and specific ones characterizing liver damage. As a result, hepatonecrosis may develop. The hepatotoxic effect of paracetamol can be complicated by the development of hepatic encephalopathy (thought disturbances, central nervous system depression, stupor), convulsions, respiratory depression, coma, cerebral edema, hypocoagulation, development of disseminated intravascular coagulation syndrome, hypoglycemia, metabolic acidosis, arrhythmia, collapse. Rarely, liver dysfunction develops at lightning speed and can be complicated by renal failure (renal tubular necrosis). Treatment: administration of SH-group donors and precursors of glutathione synthesis - methionine 8-9 hours after an overdose and N-acetylcysteine - after 12 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined in depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Interactions with other drugs Reduces the effectiveness of uricosuric drugs. Concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs (decreased synthesis of procoagulant factors in the liver). Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a slight overdose. Long-term use of barbiturates reduces the effectiveness of paracetamol. Ethanol contributes to the development of acute pancreatitis.

Inhibitors of microsomal oxidation (incl.

including cimetidine) reduce the risk of hepatotoxicity.

Precautions for use It is not recommended to combine it with other medications that contain paracetamol or give it to children under 6 years of age. Caution should be exercised in severely impaired liver or kidney function. During treatment it is necessary to avoid drinking alcohol.

Special instructions for use If the febrile syndrome continues during the use of paracetamol for more than 3 days and pain syndrome for more than 5 days, a doctor’s consultation is required. The risk of developing liver damage increases in patients with alcoholic hepatosis. Distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma. During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary.

Storage conditions At a temperature not exceeding 25 °C.

Shelf life: 60 months.

Disease classes

ATC classifier

Nervous system

Pharmacological action

Antipyretic

Description Antipyretic effect is aimed at reducing elevated body temperature. The mechanism of action is associated with inhibition of cyclooxygenase activity, decreased formation of prostaglandins, endoperoxides, bradykinins, free radicals and other pro-inflammatory biologically active substances. The concentration of prostaglandins in the thermoregulation center of the hypothalamus also decreases and heat transfer increases. Drugs that have an antipyretic effect are used to treat increased body temperature due to influenza, colds and other infectious and inflammatory diseases.

Pharmacological group

Anilides

Active ingredients

Paracetamol

Description White or white with a cream or pink tint crystalline powder. Easily soluble in alcohol, insoluble in water.

The data provided is for informational purposes only.
Before use, please consult a specialist.