Duphaston reception hours. Positive properties of Duphaston

Duphaston is a synthetic hormonal drug latest generation, which is an artificial analogue female hormone progesterone.

The unique feature of the drug is its chemical formula, which is almost identical to the structure of the natural hormone progesterone. It is necessary for the female body to ensure biological changes associated with preparation for pregnancy and its normal course. The basis of the drug is the progestogen hormone – dydrogesterone. It acts directly on the uterine mucosa, which eliminates most side effects accompanying the use of other synthetic hormones.

On this page you will find all the information about Duphaston: full instructions on application to this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Duphaston. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The active component of the drug dydrogesterone is an analogue of natural progesterone. Duphaston is a hormonal drug.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Duphaston cost? Average price in pharmacies it is at the level of 480 rubles.

Release form and composition

Film-coated tablets, 10 mg. 20 tablets in PVC/Al blister. 1 PVC/Al blister along with instructions for use is placed in a cardboard box.

1 film-coated tablet contains: active substance: dydrogesterone, 10 mg;
Excipients: lactose monohydrate, hypromellose, corn starch, colloidal silicon dioxide, magnesium stearate;
Shell: Opadry white Y-1-7000 (hypromellose, polyethylene glycol 400, titanium dioxide (El 71)).

Round biconvex tablet white, beveled, film-coated, scored on one side, engraved with an “S” over the “T” on one side of the tablet and “155” on the other side (on both sides of the score).

Pharmacological effect

In its own way molecular structure, pharmacological and chemical properties Dydrogesterone is close to natural progesterone. This element is not a testosterone derivative and does not have the side effects that are inherent in almost all synthetic progestogens, which are also called androgenic progestogens. Dydrogetestrone has no glucocorticoid, anabolic, androgenic, estrogenic or thermogenic activity.

According to the instructions, Duphaston is part of complex HRT for menopause; the drug retains a beneficial effect on lipid profile blood from estrogen. Unlike estrogen hormones, which negatively affect the blood coagulation system, dydrogestron has no effect on the coagulation rate. The drug does not have instructions for planning conception negative influence on liver function, carbohydrate metabolism.

At orally Dydrogesterone selectively acts on the endometrium, this helps prevent an increased risk of developing hyperplasia or carcinogenesis due to excess estrogen. The medication according to the instructions is indicated for endogenous progesterone deficiency. Duphaston doesn't have it contraceptive effect, because it is used when planning pregnancy. The drug makes conception possible and ensures the maintenance of pregnancy during therapy.

Indications for use

The use of Duphaston is indicated in cases where there is or suspected deficiency of endogenous progesterone, in cases where its positive effect has been clinically proven:

infertility caused by luteal insufficiency;
threatened abortion;
habitual abortion;
premenstrual syndrome;
dysmenorrhea;
irregular cycle.

In addition, in combination with estrogens, Duphaston can be used for:

secondary amenorrhea;
dysfunctional uterine bleeding.

Contraindications

You should not take the medicine:

Lactase deficiency, galactose and glucose intolerance, malabsorption syndrome;
Breastfeeding period;
Hypersensitivity to the components of the drug.

If the patient's history indicates itchy skin at previous pregnancy Duphaston should be used with caution.

Use during pregnancy and lactation

According to the instructions, Duphaston is used during pregnancy according to indications.

Since dydrogesterone can be released from breast milk, if necessary, treatment with the drug is recommended to be stopped breast-feeding.

Instructions for use

The instructions for use indicate that Duphaston tablets are taken orally. The dosage of the drug must correspond to the diagnosis. Treatment is carried out only as prescribed by a doctor and under medical supervision.

Infertility caused by luteal insufficiency– prescribe 1 tablet per day from the 14th to the 25th day of the cycle. The drug is taken for at least six months or 6 cycles. If conception has already occurred, then Duphaston should be taken further, as if there is a threat of abortion.
Endometriosis - dosage 10 mg (1 tablet) 2 to 3 times a day. Start either from the 5th to the 25th day of the monthly cycle, or continuous use.
Habitual abortion - take 1 tablet 2 times a day. Treatment should be continued until the 20th week of pregnancy, then the dosage is gradually reduced.
Threatened abortion– take 40 mg (4 tablets) once. Then 1 tablet every 8 hours until the situation returns to normal. If symptoms begin to increase again, the dose of the drug should be increased again. Next, Duphaston should be taken until 12–20 weeks of pregnancy.
Prolonged absence of menstruation (amenorrhea)– complex treatment – estrogen-containing drugs, 1 tablet per day, starting from the 1st day of the cycle. From the 11th day of the cycle, treatment is supplemented with Duphaston. These drugs should be taken until the 25th day of the cycle. Application is intended for at least 3 menstrual cycles.
Painful periods– 1 tablet 2 times a day. Use is indicated from the 5th to the 25th day of the cycle.
PMS - prescribed 1 tablet 2 times a day. Treatment is carried out from the 11th to the 25th day of the cycle. The drug is prescribed for a period of 3 to 6 months.
Irregular monthly cycle – the drug is prescribed in 1 tablet. 2 times a day. Duphaston should be used from the 11th to the 25th day of the cycle.
Hormone replacement therapy– prescribed in combination with estrogens, 1 tablet 1 time per day for 2 weeks within a 28-day cycle. Usually the reception takes place in the last 14 days of the cycle. If the response to progesterone therapy is not detected by ultrasound and is not confirmed by tests, then the dose should be revised upward.
Dysfunctional uterine bleeding– the dose is 1 tablet. 2 times a day. The duration of treatment is from 5 to 7 days. To prevent bleeding, the drug is prescribed - 1 table. 2 times a day. Therapy is carried out from the 11th to the 25th day of the cycle.

Side effects

When taking Duphaston, it is possible to develop adverse reactions:

The hematopoietic system may respond to the drug with symptoms of hemolytic anemia.
From the central nervous system, dizziness and headaches are possible.
From the genital area, breakthrough uterine bleeding sometimes occurs, and sometimes there is soreness and swelling of the mammary glands.
Possible on the skin allergic manifestations in the form of urticaria, itching, skin rash. Very in rare cases the development of a complication such as Quincke's edema is noted.
In some cases, problems with the liver are noted, expressed in weakness and malaise, jaundice; some patients note that their stomach hurts after Duphaston.

Uterine bleeding when taking the drug is easily stopped by increasing the dose of Duphaston. If adverse reactions occur, you should consult your doctor; dosage adjustment may be necessary, and if allergic reactions- drug withdrawal.

Overdose

There have been no reports of overdose symptoms. In case of accidental ingestion at a dose significantly higher than the therapeutic dose, gastric lavage is recommended. There is no specific antidote; treatment should be symptomatic.

Special instructions

Currently, there is no data on the negative effects of dydrogesterone in chronic renal failure.

Requires careful clinical examination when there is a history of a progesterone-dependent tumor (for example, meningioma), as well as in case of its progression during pregnancy or during the previous one hormone therapy.

If dydrogesterone is prescribed in combination with estrogens (for example, for replacement therapy hormones), contraindications and warnings associated with the use of estrogens should be taken into account.

Before starting hormone replacement therapy (HRT), a complete medical history should be obtained. During treatment, it is recommended to periodically monitor individual tolerance HRT. The patient should be informed about what changes in the mammary glands she should report to the doctor. Studies including mammography should be performed in accordance with routine patient screening.

Sometimes breakthrough symptoms may occur during the first months of treatment. uterine bleeding. If breakthrough bleeding occur after a certain period of taking the drug or continue after a course of treatment, the cause should be studied and an endometrial biopsy should be performed to exclude malignant changes in the endometrium.

Duphaston tablets should not be prescribed to patients with genetically determined galactose intolerance, lactase deficiency or malabsorption syndrome.

Drug interactions

There may be a slight decrease in the effectiveness of Duphaston when taken in parallel with Rifampicin or Phenobarbital, which affect microsomal liver enzymes. These drugs can increase the rate of biological transformation of the hormonal drug Duphaston.

ABOUT drug incompatibility To date, there has been no information on Duphaston with other drugs.

When prescribing a gestagen in parallel with estrogens, it is advisable to take into account the indications and contraindications for the latter.

How wonderful it is when menstrual cycle stable, you don’t need to take anything to ovulate. But if you look around, you can see a lot of girls attending antenatal clinics, undergoing tests, and undergoing treatment courses. Problems with conception are often caused by hormonal disorders, and one of the drugs that solves these problems and is prescribed when planning pregnancy is Duphaston. Let's talk about him.

When tests show that there is little in the body, doctors recommend the drug Duphaston. This remedy helps restore normalcy and helps you get pregnant.

The medicine is prescribed when the body does not produce required quantity progesterone. Sometimes it is not canceled until the third trimester - at this time it is already formed, producing progesterone. The drug is absolutely safe even for a pregnant woman and baby. It also does not affect blood clotting and does not negatively affect the liver.

Is it possible to get pregnant after taking Duphaston? Yes, many gynecologists recommend this remedy, as it has shown excellent results.

You can get pregnant on Duphaston - it compensates for the lack of progesterone and is its synthetic analogue.

Doctors prescribe the drug in cases where problems with conception are associated with a lack of the hormone:

uterine bleeding;
amenorrhea.

It is important for the patient to know exactly how to drink Duphaston in order to become pregnant. The drug must be taken on certain days of the menstrual cycle, otherwise it can act as a contraceptive.

Does Duphaston help you get pregnant? Yes, because it contains artificial progesterone, called the “pregnancy hormone”. IN natural conditions its production occurs on the postovular days of the cycle, preparing the uterus for possible conception. To determine whether the cause of problems with conception is indeed hormonal abnormalities, you need to contact antenatal clinic and get tested.

How to drink medicine Duphaston when planning a pregnancy in the near future? Usually they start taking it from the 16th to 25th day of the menstrual cycle. If pregnancy has occurred, then use continues until week 20, after which the dosage is gradually reduced.

Doctors prescribe the drug for at least three months. If conception has not occurred during this time, Duphaston can be taken for up to 6 months.

Effect of the drug on the cycle

U healthy woman Menstruation should be monthly. Occasional cycle failures may be acceptable as long as they are intermittent. Long delays may be caused by insufficient progesterone. The indication for taking Duphaston is amenorrhea, which is caused by a malfunction of the ovaries. When a diagnosis of “secondary amenorrhea” is made (no periods for more than 6 months), doctors prescribe hormonal treatment, which is combined with physical activity and diet.

They drink Duphaston in the second phase of the cycle, replenishing the progesterone deficiency. Menstruation should become regular while taking the drug.

Sometimes women themselves begin to take the drug to combat amenorrhea, without first consulting a doctor. This cannot be done, because even greater violations may appear in endocrine system, which will be very difficult to cope with.

The drug can help prevent bleeding that occurs in the middle of the cycle, and it also reduces pain during menstruation. But to have a positive effect, you need to drink it regularly.

Contraindications for use

Will Duphaston help you get pregnant? Of course, yes, but doctors must take into account both indications and contraindications for its use. An incorrect attitude to this issue can negatively affect a woman’s health.

The main contraindications are as follows:

chronic renal failure;
hypersensitivity to the components of the drug;
hereditary pathologies, for example, Dubin-Johnson and Rotor syndromes.

Before taking the drug Duphaston when planning long-awaited pregnancy, you need to pay attention to your health. For example, if a patient has problems with cardiovascular system or diabetes, she needs to be careful when taking this drug. The doctor must constantly monitor her health.

You can take Duphaston to get pregnant with peace of mind, as it is safe. The same applies to the period of pregnancy itself. But during lactation, it is advisable that the patient does not drink it. The main component of the drug, dydrogesterone, is excreted in mother's milk and makes breastfeeding impossible for the baby.

Taking the drug correctly

Before taking Duphaston when planning a pregnancy, you need to read the instructions and remember that only a doctor can prescribe it. He monitors the patient and is familiar with the peculiarities of the course of the disease.

Rules of admission for various pathologies:

PMS and irregular critical days- from 11 to 25 days of the menstrual cycle. When planning pregnancy, Duphaston is taken in a dosage of 10 mg twice a day.
Dysmenorrhea (mild critical days) - from 5 to 25 days. Dosage: 10 mg twice a day.
How to take Duphaston to get pregnant with amenorrhea? From 11 to 25 days of the expected cycle. Dosage: 10 mg twice a day. Additionally, you need to take estrogen.
Duphaston for endometriosis during pregnancy planning is taken from 5 to 25 days. Dosage - 3 times a day, 10 mg.
In case of infertility due to a lack of progesterone, the drug is taken from the 14th to 25th day of the cycle. When planning pregnancy, the dosage of Duphaston in these circumstances is 10 mg once a day. The course lasts 6 cycles in a row. If Duphaston helped you get pregnant, then you should not stop taking it for another 3 months.
The drug copes well with uterine bleeding. In this case, you need to take it for 7 days, 10 mg twice a day.

Use during pregnancy

So, you can get pregnant while taking Duphaston, but is it allowed to take it after conception? Pregnancy sometimes occurs with complications, so it is necessary to take this remedy in order to safely carry the baby. If uterine bleeding is observed, the doctor may extend the course of therapy.

Stopping the drug is developed by a doctor, since abrupt withdrawal often provokes negative reaction. If the pregnancy is progressing normally, the dosage of the medication is reduced by half, and the woman’s well-being is monitored by the attending physician. If there are fluctuations in the level of the hormone progesterone due to a decrease in dosage, the process of stopping the medication will continue for another 2-3 weeks.

Those who have been helped by Duphaston to become pregnant should remember that they should not drink it after childbirth, because it has a negative effect on the baby’s body, getting there along with mother’s milk.

Duphaston or Utrozhestan - which is better?

The role of the first drug in planning conception and a successful pregnancy is well known. However, there are also effective analogues.

The main competitor of this drug is also very effective when planning conception. The drug contains progesterone, made from plant materials. For this reason, it is used in exactly the same way as its counterpart described above. No big difference is that when planning pregnancy, use - Duphaston or Utrozhestan. The doctor decides which specific drug to give preference to.

The difference between these medicines is that Duphaston - synthetic drug, and Utrozhestan is natural. But the first one has much fewer side effects.

The significant difference between these drugs is that Utrozhestan can not only be drunk, but also injected directly into the vagina, which prevents the development of allergic reactions. The doctor will decide which drug to prescribe for therapy.

Side effects from taking Duphaston

Duphaston can be used when planning pregnancy because it has few side effects. It does not affect ovulation, and conception often occurs when taking it. But it is not 100% safe. There are such side effects like nausea, dizziness, bloating.

Taking Duphaston when planning pregnancy in rare cases can cause liver dysfunction and anemia. It is not recommended for women with pathologies of the heart, liver, kidneys, or pancreas.

To prevent side effects, you need to know how to properly take synthetic Duphaston when planning pregnancy. First, an examination is carried out, based on which the gynecologist determines the duration of treatment and the required dosage.

When a doctor recommends taking Duphaston when planning a pregnancy, there is no need to refuse - the drug is safe if you follow the instructions for its use. The medicine has proven itself well. If a woman is wondering whether it is possible to get pregnant on Duphaston, then she needs to know that only correct application This drug, under the supervision of a specialist, will help solve the problem.

Useful video about pregnancy planning

Replies

In this article we will talk about a hormonal drug called Duphaston, which is currently widely used in therapy women's diseases. We will discuss detailed instructions on the use of the product and consider cases in which you should not use this drug.

» instructions for use

Today, Duphaston is the most commonly used hormonal drug in the field of gynecology. This drug is similar in properties to the hormone progesterone.
In accordance with the days of the female menstrual cycle, the predominance of the hormones estrogen and progesterone alternates cyclically, and an insufficient amount of progesterone in the female body can be the cause of the development of various pathologies
Progesterone is involved in the process of preparing the female body to maintain and carry a pregnancy. Since an insufficient amount of this female sex hormone can cause the development of diseases, the drug “Duphaston” is often prescribed by gynecologists for therapy

« Duphaston" when planning pregnancy

"Duphaston" when planning pregnancy

Since Duphaston is an analogue of progesterone, the pregnancy hormone, it is often prescribed during pregnancy planning and gestation.
The substance has a high rate of absorption from the gastrointestinal tract and the maximum of the substance in the blood plasma occurs after 2 hours
To ensure a sufficient level of progesterone in a woman’s blood during pregnancy planning, a special regimen for taking it has been developed.
It is prescribed in the second phase of the menstrual cycle after the onset of ovulation, that is, on average from the 11th to the 25th day of this cycle. During this time, it is recommended to take 1 tablet of the drug once a day. If necessary, the dose of the drug is increased by the treating gynecologist.
For a positive effect of treatment, the drug is prescribed for a duration of 6 months, and only after this period is it recommended to plan to conceive a baby. The same recommendations apply to preparing a woman for IVF
Before prescribing a course of this therapy, it is necessary to undergo a series of tests for the content of sex hormones in the blood and determine their current level before starting therapy with Duphaston.
For the accuracy of the tests, it is necessary to know exactly the day of ovulation; for this, a woman must monitor her basal temperature for a month
It should be noted that pregnancy occurs already at 3-6 months of Duphaston therapy

« Duphaston "by days of the cycle "Duphaston" from 16 to 25 days of the cycle

"Duphaston" by days of the cycle "Duphaston" from 16 to 25 days of the cycle

As strange as it may sound, not all women calculate their menstrual cycle correctly. Therefore, first, let’s determine how long a woman’s cycle lasts.
The days of the cycle begin to be counted from the first day of the beginning of menstruation until the first day of the beginning of the next menstruation. On average, this period is 28 days, but the norm can be an interval from 25 days to 35 on average
As we mentioned earlier, for treatment in preparation for conception, Duphaston is prescribed for use after ovulation. This is done with the aim of getting into the biological rhythm of increasing the concentration of progesterone in the female body. And this happens precisely in the second phase of the menstrual cycle.
Depending on the day of ovulation and the length of the cycle, this period falls in the middle of the period of time between the beginnings of the last two menstruation
For example, if your cycle lasts 25 days, and ovulation occurred on the 16th day of the cycle, then Duphaston is prescribed from the 16th to the 25th day. Then the reception is interrupted until the next ovulation

Menstruation after Duphaston

"Duphaston" is prescribed precisely in cases where the menstrual cycle is interrupted and delayed due to a lack of the hormone progesterone in the female body. Normally, progesterone affects the endometrium of the uterus, stimulating its thickening and loosening. All these processes prepare the uterus for implantation. fertilized eggs
If there is a lack of the hormone, the endometrium does not grow and menstruation may be scanty or absent altogether. In this case, the drug is most effective
"Duphaston" does not have an inhibitory effect on the reproductive function of the ovaries, therefore, in the absence of ovulation, it is also prescribed. In this case, progesterone artificially provokes the onset of menstrual bleeding, and when it is canceled, ovarian function often occurs is being restored on one's own

« Duphaston » indications for use

"Duphaston" indications for use

"Duphaston" is prescribed not only for planning or maintaining pregnancy. This drug has a number of indications for use in the following diseases:

Development threat spontaneous abortion
Infertility associated with lutein deficiency
Endometroiosis
Habitual abortion
Premenstrual syndrome (PMS)
Algomenorrhea(painful menstruation and cycle disruption)
Amenorrhea (lack of menstruation)
Uterine bleeding associated with dysfunction
Hormone replacement therapy
Maintaining or planning a pregnancy

« Duphaston » dosage

"Duphaston" dosage

For each of the listed diseases, a specific course of treatment with this drug is prescribed with a specific dosage regimen. The dose of use can vary quite a lot, depending on the level of the hormone progesterone in the woman’s blood.

The duration of the course, regimen and dose of taking this drug can only be determined by your treating gynecologist. Do not take the product yourself, as uncontrolled use of the hormone can harm you.

Average doses:
For endometriosis, 10 mg up to 3 times a day (days 5–25 of the cycle)
Infertility - 10 mg 1 time per day (days 14-25 of the cycle)
Threatened miscarriage 10 mg 2 times a day (up to 20 weeks)
PMS - 10 mg 2 times a day (days 11-25 of the cycle)

Remember!!! Only the doctor prescribes the regimen and dosage.

« Duphaston » side effects

Duphaston side effects

Side effects of taking this drug include the following conditions:

Development iron deficiency anemia
Development of allergic reactions to the components of the product
Migraines and headaches
Very rarely, so-called breakthrough uterine bleeding associated with high levels of progesterone in the blood may develop, and the breasts may also swell and be painful on palpation
The liver can also very rarely be affected, accompanied development of pain in the epigastric region and symptoms of hepatitis
Skin manifestations of an allergic reaction in the form of itching and redness, and an edematous condition may also develop

« Duphaston » contraindications

Duphaston contraindications

The drug is contraindicated for use in the following conditions:
If elevated sensitivity to this drug or its components
Marked itching or redness of the skin during previous pregnancies
Duphaston should not be prescribed if there is malabsorption syndrome or if intolerance galactose woman
The drug is prescribed with caution if a woman has migraines, a history of epileptic seizures and metabolic diseases
When using the drug for replacement therapy, constant ultrasound monitoring of the condition of the pelvic organs and regular mammography are required.

« Duphaston » for children

This drug is not usually prescribed in childhood. The exception is the onset of puberty in a girl and the impossibility of establishing her menstrual cycle for up to a year.

If the cycle has not been established, then it is possible to use hormonal drugs, but strictly as prescribed by a pediatric gynecologist and under the control of blood tests and other research methods.

« Duphaston » analogues

The drug has no structural analogues. He has others patented titles:
Utrozhestan
Prajesan

Video: Duphaston

One of the frequently prescribed gynecological practice drugs is duphaston - a synthesized analogue of the natural female hormone progesterone, which is necessary for a number of important biological changes in female body. All these changes serve one great purpose: preparing for pregnancy and ensuring its normal course. The results of progesterone activity are manifested in increased secretory activity of the uterus, suppression contractile activity its smooth muscle fibers, inhibition immunological reactions rejection of the embryo by the mother's body and much more.

Modern pharmaceuticals have several effective substitutes for this hormone, but most of them were synthesized on the structural basis of male sex hormones, and therefore their use is accompanied by such side effects as the appearance in women of secondary male sexual characteristics in the form of increased hair growth on unusual areas. female body areas (beard, mustache), deepening of the voice, acne, etc. In addition, complications of the functional activity of the liver and a shift in the ratio of lipid fractions of the blood may occur.

Duphaston has something completely different chemical structure, which has nothing to do with male sex hormones. On the contrary, it is as close as possible to the structure of progesterone produced by the body itself. Therefore, its use is not associated with negative effects, characteristic of the majority similar drugs. Moreover, due to certain components, some experts are inclined to consider duphaston even more preferable than a natural hormone.

Duphaston is very popular pharmacological drug, which is successfully used to treat pathologies caused by a lack of the female hormone progesterone. However, improper use of the drug can seriously harm your health. Therefore, it is so important to listen to doctors’ recommendations on how to use Duphaston.

Different pathologies - one solution

The importance of progesterone for women's health difficult to overestimate. The lack of this hormone leads to many pathologies: endometriosis, menstrual irregularities, difficulties with conception. , habitual miscarriages and other serious problems.

If a woman’s body does not produce sufficient quantity progesterone, synthetic analogs come to the rescue.

The hormone dydrogesterone, which is part of Duphaston, is as close in composition as possible to natural progesterone, so this drug is actively used in hormone replacement therapy and to combat diseases caused by progesterone deficiency in the body.

Purpose

Duphaston is used for infertility associated with functional impairment corpus luteum, “habitual” abortions associated with increased activity smooth uterine muscles, various violations menstrual cycle, endometriosis, etc. In combination with other medications Duphaston is effective in the treatment of uterine bleeding and pathological absence of menstruation. This drug is often prescribed after treatment with estrogens in order to prevent cancerous transformation of the uterine mucosa that has grown due to estrogen.

Some liver diseases are contraindications for treatment with duphaston. , as a result of which the amount of bilirubin in the blood increases. Also, you should not use the drug if you have allergic reactions to its constituent ingredients. The drug should be used with caution if there is serious illnesses heart and kidneys, as well as for epilepsy. If there are appropriate indications, the medication can be taken during pregnancy, but it is undesirable during breastfeeding due to its ability to be excreted in breast milk. Side effects Duphaston has virtually no effect, but sometimes uterine bleeding is possible.

Reviews about the effect of duphaston are mostly positive: the drug does not have a depressing effect on reflex reactions nervous system, so it does not impair control abilities vehicle. Patients taking duphaston can lead a full life.

How to use duphaston

Duphaston is taken orally (that is, through the mouth), since it is very quickly absorbed from gastrointestinal tract. After just a couple of hours, the concentration of the drug in the blood reaches its maximum, although it is eliminated very quickly: after a day, only 15% of the drug remains in the body, and after three days there is none left at all. Hence the two or three times a day regimen. The main route of elimination is through the kidneys.

Duphaston can be safely combined with other medicines. Almost the only medications that are not recommended to be combined with duphaston due to its weakening therapeutic effect, are homologs of phenobarbital.

Despite the minimum of contraindications and side effects, duphaston should not be used as part of self-medication. Thus, before prescribing a therapeutic course with this drug, general medical care is required, including gynecological examination. It is also advisable to take a chest x-ray, the frequency of which will be determined by the attending physician.

Correct Application

Duphaston is used orally, in tablet form. This method of administration is undoubtedly more convenient than injections, since a woman can treat herself. After two hours, the concentration of the hormone in the blood is maximum. The drug is eliminated through the kidneys, and this also happens quickly: within three days after taking Duphaston, not a trace remains of it. That is why it is recommended to take this medication regularly, which allows you to constantly maintain the required concentration of the hormone in the body.

Methods of application and doses of Duphaston depend on what specific pathology needs to be eliminated.

So, for the treatment of endometriosis, Duphaston should be taken from the fifth to the twenty-fifth day of the cycle, ten milligrams daily, two to three times a day. You should take the drug according to the same regimen for dysmenorrhea.

At irregular menstruation and premenstrual syndrome, Duphaston is prescribed twice a day, one tablet from the eleventh to the twenty-fifth day of the cycle. For the treatment of amenorrhea Duphaston is taken according to the same scheme; in addition, estrogen preparations are also taken from the first to the twenty-fifth day of the cycle.

To stop dysfunctional uterine bleeding, Duphaston is taken for five to seven days, ten milligrams twice a day. To prevent bleeding, the drug should be taken from the eleventh to twenty-fifth days of the cycle twice a day, ten milligrams.

This drug is used to treat infertility caused by luteal insufficiency. The course of treatment is at least six months (six cycles in a row), and when pregnancy occurs, it is recommended to continue taking Duphaston for several months, as with a conventional abortion. The drug should be taken once a day, one tablet, from the fourteenth to the twenty-fifth days of the cycle.

Duphaston is used in combination with estrogens in hormone replacement therapy. The regimen for taking the drug depends on the regimen for taking estrogen. So, if estrogens are taken continuously, then Duphaston is prescribed one tablet per day for fourteen days. This is followed by a two-week break, and the drug is resumed again for fourteen days. If estrogens are taken on a cyclic basis, Duphaston should be taken one tablet per day during the last twelve to fourteen days of taking estrogens. In this case, regular ultrasound examinations to monitor the effect of the drug. In some cases, the dose of Duphaston is indicated to be increased to twenty milligrams per day.

During pregnancy

With a habitual abortion, Duphaston must be taken until the twentieth week of pregnancy, one tablet twice a day daily. After this, the doctor gradually reduces the dose of the hormone. It is very important that the dose reduction be gradual: abrupt refusal Taking the drug can cause a miscarriage.

Duphaston is also indispensable if there is a threat of miscarriage: when dangerous symptoms you should take 4 tablets once, and then take ten milligrams of Duphaston every eight hours until the symptoms disappear.

The drug Duphaston - hormonal agent, having quite wide range actions and helping to combat problems of the female genital area. These include polycystic ovary syndrome, irregularities in the menstrual cycle, endometriosis, and even infertility. How does it work in each of these cases?

Features of the drug

Duphaston is an analogue of the female hormone progesterone dydrogesterone, created in a laboratory. It is absolutely safe for the body. The structure of the drug is very similar to the natural hormone.

It has an effect on the uterine mucosa, in particular on the receptors that are most sensitive to it.

A lack of progesterone in the body leads to headaches, sudden mood swings, swollen breasts and abdominal area, and excessive fatigue. If this is the period before menstruation, insufficient quantity hormone leads to sudden weight gain and severe pain in the lower abdomen. Duphaston helps solve these problems.

Why take it?

Why is Duphaston prescribed in each specific case? Its action depends on the situation.

Before conception

When planning a pregnancy, a woman needs to be tested for the level of progesterone in her blood. If it is underestimated, the doctor will prescribe Duphaston as the main treatment. It will speed up conception and promote light current pregnancy in the first 3-4 months.

There are several cases when treatment with Duphaston is mandatory:

Endometrial problems

When a woman’s body lacks progesterone, the endometrium (uterine lining) greatly increases in size. It can peel away from the walls of the uterus and cause heavy bleeding.

In most cases, Duphaston helps to overcome this disease:

When pregnancy has already occurred

Why is Duphaston prescribed to pregnant women:

During pregnancy, the drug reduces the tone of the uterus, which can cause miscarriage or premature birth.
Participates in preparing the breast for feeding.
Helps the body accumulate fat necessary for bearing a child.
Stops the removal process ovum from the uterus (spontaneous abortion).
Improves the condition of the endometrium.

Disturbances in the hormonal system

Disturbances may occur in the functioning of a woman's reproductive system. They are called for various reasons. Most often, violations relate to the menstrual cycle. This is dysmenorrhea ( severe pain lower abdomen before and during menstruation), severe premenstrual syndrome (PMS), amenorrhea (no menstruation).

How does Duphaston combat these problems? Regular menstruation is a sign that a woman’s body clearly performs all its functions. The duration of the menstrual cycle is on average 28 days. If after this time there are no periods, it means a failure has occurred. It is usually caused by disturbances in hormonal system, in particular, a lack of progesterone. Duphaston is prescribed to bring the menstrual cycle back to normal.

What does a proper cycle look like? In the second week of the cycle, the ovarian membrane ruptures, after which a mature egg emerges. At the same time, the corpus luteum appears, which is responsible for the production of progesterone. A sufficient amount of it launches such important processes, like growth and renewal of the endometrium. It also allows the body to carry a child.

Low levels of progesterone prevent the task from being completed, and Duphaston helps the mother’s body cope with the task assigned to it.

The moment progesterone levels return to normal, the menstrual cycle becomes regular. Sometimes disturbances in the hormonal system lead to the appearance of tumors. Cysts form in the cavity corpus luteum. They will resolve on their own if there is enough female hormone in the body. Otherwise, the cyst will continue to grow. In this case, taking Duphaston is mandatory.

Polycystic

Polycystic ovary syndrome is a disease associated, again, with disturbances in the hormonal system. Duphaston is prescribed to normalize hormonal background.

Women who suffer from polycystic ovary syndrome are more at risk of miscarriage than others. On early stages they may have a miscarriage or spontaneous abortion. Premature birth or isthmic-cervical insufficiency (the cervix can no longer hold the fetus in the womb) often occurs.

For polycystic disease, Duphaston is prescribed until the 16th week of pregnancy. It was during this period that the placenta itself begins to produce progesterone.

Important Rules

Duphaston is a hormonal drug. Therefore, it should be prescribed exclusively by the attending physician. He also determines the dose and duration of treatment. The use of Duphaston must obey certain rules:

How to take

The dosage of the drug depends on the specific case.

Sometimes Duphaston is prescribed for menopause. It is usually combined with other drugs that restore a woman’s hormonal levels. The duration of treatment is 14 days.

Duphaston is a synthetic hormone that has a huge effect on a woman’s body. It not only restores the endometrium and promotes its renewal, but also prevents the formation of cysts and polyps in the uterus. Duphaston promotes conception and fixation of the embryo in the uterus, after which the fetus can grow and develop. Thanks to him the risk premature birth is reduced to a minimum.

This drug normalizes the menstrual cycle and restores a woman's ability to have children. But it is worth remembering that this hormonal medicine, and it should only be prescribed by a doctor.