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Aspirin (Acetylsalicylic acid). Acetylsalicylic acid: instructions for use

Acidum acetylsalicylicum Analogs

(generics, synonyms)

Recipe

Rp.: Acidi acetylsalicylici 0.5

D.t. d. No. 10 in tab.

S.: 1 tablet each. 3-4 times a day after meals.

pharmachologic effect

Non-steroidal anti-inflammatory drug. It has anti-inflammatory, analgesic, antipyretic effects, and also inhibits platelet aggregation. The mechanism of action is associated with inhibition of the activity of cyclooxygenase, the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.

The analgesic effect of acetylsalicylic acid is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Due to a decrease in the production of prostaglandins, their effect on thermoregulation centers decreases. An irreversible disruption of the synthesis of thromboxane A2 in platelets causes the antiplatelet effect of acetylsalicylic acid. In high doses, acetylsalicylic acid inhibits prothrombin synthesis in the liver and increases prothrombin time.

Mode of application
Acetylsalicylic acid is taken orally, after meals, with plenty of liquid - water.
For pain syndrome, adults are recommended to take 250-500 mg/day (1/2-1 tablet) 3-6 times/day. The interval between doses should be at least 4 hours. The maximum single dose is 1000 mg, the maximum daily dose is 3000 mg.
For children over 16 years of age, a single dose of 250 mg (1/2 tablet) 2 times a day, maximum daily dose of 750 mg.
As an antipyretic, it is prescribed at a body temperature of more than 38.5°C (in patients with a history of febrile seizures - at a temperature of more than 37.5°C) at a dose of 500-1000 mg.

The duration of treatment (without consulting a doctor) should not exceed 5 days when prescribed as an analgesic and more than 3 days when prescribed as an antipyretic.

Indications
— pain syndrome of weak and moderate intensity of various etiologies (including headaches - migraine, toothache, neuralgia, myalgia, joint pain, lumbago);

- elevated temperature (fever) with influenza, colds (ARVI) and other infectious and inflammatory diseases.

- hypersensitivity to salicylic acid, its derivatives or other non-steroidal anti-inflammatory drugs;
— erosive and ulcerative lesions of the gastrointestinal tract in the acute stage of hemorrhagic diathesis
- predisposition to hemorrhages
- increased bleeding
- bleeding disorders (hemophilia, von Willebrand disease
- telangiectasia
- vitamin K deficiency
- thrombocytopenia, thrombotic thrombocytopenic purpura, hypoprothrombinemia);
- nephrolithiasis, hyperuricemia;
- deficiency of glucose-6-phosphate dehydrogenase;
- severe dysfunction of the liver and kidneys;
— pronounced disturbances in water-electrolyte balance and acid-base balance;
— pregnancy and lactation;
- children under 16 years of age;
- taking methotrexate at a dose of 15 mg per week or more;
- gout and gouty arthritis. Use caution during concomitant therapy with anticoagulants, hyperurecemia, gastric ulcer and duodenal ulcer.

Side effects

- nausea, loss of appetite, stomach pain;
- allergic reactions (skin rash, urticaria, Quincke's edema, Lyell's syndrome, bronchospasm, eosinophilia, anaphylactic shock, angioedema, "aspirin triad": a combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid);
- Reye's syndrome;
— interstitial nephritis, papillary necrosis, nephrotic syndrome;
- thrombocytopenia, anemia, leukopenia;
- impaired liver and kidney function, renal failure;
- dizziness, headache, tinnitus, decreased hearing acuity;
- erosive and ulcerative lesions of the mucous membrane of the stomach and duodenum, gastrointestinal bleeding;
- increased severity of heart failure;
- aseptic meningitis.

Release form

Tab. 500 mg: 10 pcs.
The tablets are white, round in shape, with a flat-cylindrical surface, scored on one side and beveled on both sides. 1 tab.
acetylsalicylic acid 500 mg
Excipients: potato starch, talc, citric acid monohydrate.
10 pieces. - contour cellular packaging (1) - cardboard boxes.

ATTENTION!

The information on the page you are viewing is created for informational purposes only and does not in any way promote self-medication. The resource is intended to provide healthcare workers with additional information about certain medications, thereby increasing their level of professionalism. The use of the drug "" necessarily requires consultation with a specialist, as well as his recommendations on the method of use and dosage of the medicine you have chosen.

CHAPTER 46 BASIC DOSAGE FORMS

Solid dosage forms

Tablets are a solid dosage form obtained by pressing medicinal substances, a mixture of medicinal and auxiliary substances, or forming special masses, intended mainly for oral or sublingual administration.

Examples of writing prescriptions:

Prescribe 10 tablets of acetylsalicylic acid (Acidum acetylsalicylicum) 500 mg for oral administration, 1 tablet 3 times a day after meals.

Rp.: Tabulettae Acidi acetylsalicylici 0.5

S. Take 1 tablet orally 3 times a day after meals. Prescribe 50 tablets

nikoshpan* (Nicospanum) for oral administration, 1 tablet 3 times a day after meals. Rp.: Tabuletta

Nicospanum N. 50

D.S. Take 1 tablet orally 3 times a day after meals.

Dragee is a solid dosage form for internal use, obtained by repeatedly layering medicinal and auxiliary substances onto sugar granules (grains).

Example of writing a prescription:

Prescribe 50 tablets of chlorpromazine (Chlorpromazinum) 100 mg for oral administration, 1 tablet 3

once a day after meals. Rp.: Dragee Chlorpromazini 0.1

S. Take 1 tablet orally 3 times a day after meals.

Powders are a solid dosage form for internal and external use, consisting of one or more crushed substances and having the property of flowability.

Capsules are a dosage form consisting of a drug enclosed in a shell.

Examples of writing prescriptions:

Prescribe 20 g of the finest streptocidum powder for application to the wound surface. Rp.: Streptocidi subtilissimi 20.0 D. S. Apply to the wound surface.

Prescribe a powder consisting of zinc oxide (Zinci oxydum) and talc (Talcum) 10 g as a powder on the affected areas of the skin 2 times a day.

Rp.: Zinci oxydi

M.f. pulvis subtilissimus.

D.S. Sprinkle on affected areas of skin 2 times a day.

Prescribe 30 g of magnesium oxide (Magnesii oxydum) for oral administration, 1/4 teaspoon, 1 hour after meals as a suspension in 1/3 glass of warm water.

Rp.: Magnesii oxydi 30.0

D. S. Take 1/4 teaspoon orally 1 hour after meals as a suspension in 1/3 glass of warm water.

Prescribe 10 powders in wax paper, 500 mg of analgin (Analginum) for oral administration, 1 powder each for headaches.

Rp.: Analgini 0.5

D.t. d. N. 10 in charta cerata

Prescribe 30 gelatin capsules with oxacillin sodium * (Oxacillin-natrium) 250 mg for oral administration, 1 capsule 4 times a day 2 hours before meals.

Rp.: Oxacillini-natrii 0.25

D.t. d. N. 30 in capsulis gelatinosis

S. Take 1 capsule orally 4 times a day 2 hours before meals. Prescribe 30 ascorbic acid powders (Acidum ascorbicum) 50 mg each for oral administration, 1 powder 3 times a day. Rp.: Acidi ascorbinici 0.05 Sacchari0.3 M. f. pulvis

S. Take 1 powder orally 3 times a day.

Prescribe 10 powders containing 200 mg of analgin (Analginum) and paracetamol (Paracetamolum) for oral administration, 1 powder each for headaches.

Paracetamol aa 0.2

S. Take 1 powder orally for headaches.

Soft dosage forms

Ointments are soft dosage forms that have a viscous consistency and are prescribed for external use.

Prescribe 10 g of ointment containing 0.25% oxolinum (Oxolinum) for application to the mucous membrane of the nasal cavity 2 times a day. Rp.: Unguenti Oxolini 0.25% - 10.0

D. S. Apply to the mucous membrane of the nasal cavity 2 times a day. Prescribe 10 g of ointment containing 0.1 g of menthol (Mentholum) and 0.2 g of protargolum (Protargolum) for application to the nasal mucosa.

Rp.: Mentholi 0.1

Protargoli 0.2 Vaselini ad 10.0 M. f. unguentum

D. S. Apply to the mucous membrane of the nasal cavity. Pastes are types of ointments containing at least 25% powdery substances.

Example of writing a prescription:

Prescribe 50 g of paste containing 5 g of anesthesin (Anaesthesinum) and salicylic acid (Acidum salicylicum) for application to the affected areas of the skin.

Rp.: Anaesthesini

Acidi salicylici aa 5.0

Amyli 10.0 Vaselini ad 50.0

Suppositories are dosed dosage forms that are solid at room temperature and melt or dissolve at body temperature.

There are rectal suppositories (suppositories) - suppositoria rectalia, vaginal - suppositoria vaginalia.

Examples of writing prescriptions:

Prescribe 20 vaginal suppositories containing 250,000 units of nystatin (Nystatinum), for use 1 suppository 2 times a day.

Rp.: Suppositorium cum Nystatino 250,000 units

S. 1 suppository 2 times a day.

Prescribe 10 rectal suppositories containing 250 mg of anesthesin (Anaesthesinum), for use 1 suppository at night.

Rp.: Anaesthesini 0.25

M.f. suppository rectale

S. 1 suppository at night.

Liquid dosage forms

Solutions are a liquid dosage form obtained by dissolving a drug substance (solid or liquid) in some liquid (solvent).

Examples of writing prescriptions:

Prescribe 200 ml of calcium chloride solution (Calcii chloridum; single dose - 1 g) for oral administration, 1 dessert spoon 3 times a day. Rp.: Solutionis Calcii chloridi 10% - 200 ml. D.S.

Take 1 dessert spoon 3 times a day.

Calculation:

A single dose of calcium chloride (1 g - 1.0) should be obtained in one dessert spoon (10 ml). To find the concentration of the solution as a percentage, make up the proportion: 1.0 - 10 ml

x - 100 ml; x = 10.0 (i.e. 10%).

Drops occupy a special place among liquid dosage forms in terms of the concentration of substances and the method of dosing; they can be prescribed both internally and externally.

Example of writing a prescription:

Prescribe 10 ml of haloperidol solution (Haloperidolum; single dose - 1 mg) for oral administration, 10 drops 3 times a day. Rp.: Solutionis Haloperidoli 0.2% - 10 ml D.S. Take 10 drops orally 3 times a day.

Calculation:

A single dose (1 mg - 0.001) should be obtained in 10 drops (i.e. 0.5 ml, since 1 ml of aqueous solution contains 20 drops). To find the percentage concentration of a solution, we make up the proportion:

0.001 - 0.5 ml

x - 100 ml; x = 0.2 (i.e. 0.2%).

Examples of prescribing solutions for external use: Prescribe 500 ml of 0.02% furatsilin solution(Furacilinum) for gargling 3 times a day.

Rp.: Solutionis Furacilini 0.02% - 500 ml D. S. Gargle 3 times a day.

Prescribe 100 ml of a 1% alcohol solution of salicylic acid (Acidum salicylicum) for application to the affected areas of the skin.

Rp.: Solutionis Acidi salicylici spirituosae 1% - 100 ml

D.S. Apply to affected areas of the skin.

Prescribe 100 ml of 10% camphor oil solution to rub the affected joint.

Rp.: Solutionis Camphorae oleosae 10% - 100 ml

D.S. Rub the affected joint.

Prescribe 10 ml of 0.25% solution of zinc sulfate (Zinci sulfas) for instillation, 2 drops 3 times a day in both eyes.

Rp.: Solutionis Zinci sulfatis 0.25% - 10 ml

D. S. Instill 2 drops 3 times a day into both eyes.

Note: Since all eye drops are sterilized, they may not be included in the prescription.

"Sterilisetur!"

Tinctures are a liquid dosage form, which is often an alcoholic, transparent extract from medicinal plant materials, obtained without heating or removing the extractant.

Example of writing a prescription:

Prescribe 30 ml of valerian tincture (Valeriana) for oral administration, 30 drops 3 times a day.

Rp.: Tincturae Valerianae 30 ml

D.S. Take 30 drops orally 3 times a day.

Extracts are a dosage form that is a concentrated extract from medicinal plant materials, intended for internal or external use.

Examples of writing prescriptions:

Prescribe 30 ml of buckthorn bark extract (Frangula) liquid for oral administration, 30 drops at night.

Rp.: Extracti Frangulae fluidi 30 ml

D.S. Take 30 drops orally at night.

Prescribe 10 powders of dry rhubarb root extract (Rheum) 500 mg each for oral administration, 1 powder 2 times a day before meals.

Rp.: Extracti Rhei sicci 0.5

S. Take 1 powder orally 3 times a day before meals. Infusions and decoctions are aqueous extracts from medicinal raw materials, differing in the extraction mode. Examples of writing prescriptions:

Prescribe an infusion of spring adonis herb (Adonis vernalis) in a concentration of 1:30 for oral administration, 1 tablespoon 3 times a day.

Rp.: Infusi herbae Adonidis vernalis 6.0 - 180 ml

D.S. Take 1 tablespoon orally 3 times a day.

Prescribe 200 ml of oak bark decoction (Quercus) in a concentration of 1:10 for gargling and a glass of heated decoction 3 times a day.

Rp.: Decocti corticis Quercus 200 ml

D.S. Gargle and a glass of heated broth 3 times a day.

Note: if the concentration of the infusion or decoction is 1:10, their concentrations may not be indicated.

Potions are a liquid dosage form that is a mixture of various liquid or liquid and solid medicines.

Examples of writing prescriptions:

Prescribe a mixture containing caffeine-sodium benzoate (Coffeinum-natrii benzoas; single dose - 100 mg) and sodium bromide (Natrii bromidum; single dose - 500 mg) for oral administration, 1 tablespoon 3 times a day for 4 days.

Rp.: Coffeini-natrii benzoatis 1.2

Sodium bromidi 6.0

Aquae destillatae ad 180 ml

M.D.S. Take 1 tablespoon orally 3 times a day. Calculation: Total amount of mixture - 15 ml (volume of a tablespoon) * 3 (number of doses per day) * 4 (number of days) =

Caffeine sodium benzoate should be taken: 0.1 - 15 ml (1 tablespoon)

X - 180 ml (total volume of mixture); x = 1.2.

Sodium bromide should be taken: 0.5 - 15 ml.

x - 180 ml; x = 6.0.

Prescribe a mixture consisting of 180 ml of infusion of spring adonis herb (Adonis vernalis) in a concentration of 1:30 with the addition of sodium bromide (Natrii bromidum; single dose 300 mg), for oral administration, 1 tablespoon 3 times a day.

Rp.: Infusi herbae Adonidis vernalis

Sodium bromide 3.6

M.D.S. Take 1 tablespoon orally 3 times a day.

Note: if the mixture includes a decoction or infusion, then first the infusion or decoction is prescribed according to the established rules, and then the medicinal substance is added in a dose calculated for the volume of the infusion (or decoction).

Calculation: a single dose of sodium bromide (300 mg - 0.3) should be obtained in 1 tablespoon (15 ml). The total number of doses (180 ml ÷ 15 ml) is 12.

The total amount of sodium bromide required for preparing the mixture will be: single dose χ number of doses, i.e. 0.3 χ 12 = 3.6.

Dosage forms for injections

Dosage forms for injections- a separate group of dosage forms for parenteral administration (under the skin, into a muscle, into a vein, etc.).

Examples of writing prescriptions:

Prescribe 3 ampoules of 1 ml of 2% solution of promedol (Promedolum; single dose 20 mg) for subcutaneous administration. Rp.: Solutionis Promedoli 2% - 1 ml D. t. d. N. 3 in ampullis S. Administer 1 ml subcutaneously.

Prescribe 3 bottles of insulin (Insulinum), containing 5 ml of a drug with an activity of 40 units per 1 ml. Prescribe subcutaneously, 12 units before breakfast, 18 units before lunch, 6 units before dinner.

Rp.: Insulini 5 ml (and 40 units - 1 ml)

S. Administer 12 units subcutaneously before breakfast, 18 units before lunch, 6 units before dinner.

Prescribe 30 bottles containing 500 mg of streptomycin sulfate (Streptomycini sulfas) for intramuscular administration, 500 mg 2 times a day. Before use, dissolve the contents of the bottle in 3 ml of 0.5% novocaine solution. Rp.: Streptomycini sulfatis 0.5

S. Before use, dissolve the contents of the bottle in 3 ml of 0.5% novocaine solution. Administer intramuscularly 2 times a day. Rp.: Solutionis Novocaini 0.5% - 5 ml D. t. d. N. 30 in ampullis S. For dissolving streptomycin.

Dosage forms for inhalation

Aerosols are aerodisperse systems in which the dispersion medium is air, gas or a mixture of gases, and the dispersed phase is particles of solid or liquid substances.

Example of writing a prescription:

Prescribe 1 package of aerosol Efatin* (Ephatinum). Prescribe for inhalation 2 doses 3 times a day. Rp.: Aerosolum “Ephatinum” N.1 D. S. Inhale 2 doses 3 times a day.

Acetylsalicylic acid is a drug that has a pronounced anti-inflammatory effect. The medicine eliminates fever and pain, reduces platelet aggregation. Find out how to use the drug, in what quantities to use and what acetylsalicylic acid helps with - detailed instructions for use contain all the necessary information.

S.: 1 tablet each. 3-4 times a day after meals.

The drug prevents the synthesis of prostaglandins, which are involved in inflammatory processes and contribute to the appearance of pain and fever. As a result of a significant decrease in the amount of prostaglandins, blood vessels dilate, which promotes increased sweating. So the drug has an antipyretic effect.

When using the medication, the nerve endings become less sensitive to pain. The medicine is taken orally, the maximum level of the active substance in the blood is achieved in a short time - after 10-20 minutes. The level of salicylate resulting from metabolism increases within two hours. The components of the drug are excreted by the kidneys. Partial elimination occurs 20 minutes after taking the drug; salicylate is partially removed from the body after 2 hours.

Release form and composition

Acetylsalicylic acid is available in tablets. The composition is represented by different amounts of the active substance - 100, 250, 50 mg, supplemented with citric acid and potato starch.

Aspirin and Analgin

Many people are interested in whether aspirin is acetylsalicylic acid or not? Is acetylsalicylic acid aspirin or analgin? Aspirin is a derivative of salicylic acid. Acetylsalicylic acid, often called aspirin, was obtained by replacing one hydroxyl group. Therefore, analgin is a completely different drug.

What does Acetylsalicylic acid help with?

For many decades, aspirin has been the most popular drug in the world.

The medicine is prescribed when it is detected:

fever;
rheumatoid arthritis;
rheumatic fever, occurring in acute form;
Dressler's syndrome;
rheumatic chorea;
a heart attack in which the lungs are affected;
acute thrombophlebitis;
headaches, including migraines;
osteoarthritis;
neuralgia;
various pain sensations - during dental diseases, during menstruation, accompanied by discomfort; pain in muscles and joints;
diseases of the spine accompanied by syndromes, the list is presented by osteochondrosis, sciatica, lumbago;
myocardial infarction, ischemic heart disease, atrial fibrillation, thromboembolism (used for prevention).

Contraindications and side effects

Contraindications to the use of the drug are presented in a list that includes:

portal hypertension;
bleeding in the digestive tract;
Reye's syndrome;
hemorrhagic diathesis;
aspirin triad;
insufficient amount of vitamin K in the body and glucose-6-phosphate dehydrogenase;
the presence of erosive and ulcerative lesions in the gastrointestinal tract in an acute form;
hemophilia;
insufficiency of liver and kidney functions;
the presence of a dissecting aortic aneurysm;
hypoprothrombinemia;
periods of pregnancy, lactation;
excessive sensitivity of the body to the components of this drug and other drugs that eliminate inflammatory reactions, which is manifested by the development of rhinitis and the appearance of urticaria.

Possible negative reactions

Some people may develop side effects:

diarrhea;
nausea;
skin rashes;
the appearance of tinnitus;
the occurrence of erosive and ulcerative lesions, bleeding in the digestive tract;
angioedema;
development of the aspirin triad;
the appearance of pain in the abdomen;
the occurrence of thrombocytopenia, anemia;
development of anorexia;
Reye's syndrome;
bronchospasm;
the appearance of headaches, dizziness;
visual impairment;
hemorrhagic syndrome;
deterioration of the condition in chronic heart failure;
disorders of the kidneys and liver.

If the doctor has prescribed acetylsalicylic acid, the instructions for use and contraindications should be carefully studied to avoid negative consequences.

Using large doses of the drug

If the drug is used in large quantities that do not correspond to the recommended doses, negative reactions of the body are possible. Overdose leads to the following problems:

disturbances of acid-base balance and electrolyte;
confusion;
nausea accompanied by vomiting, pain in the abdomen;
dehydration of the body;
hearing and vision problems;
tremor;
drowsy state.

In rare cases, abuse of the drug leads to metabolic acidosis and coma.

How to use

According to the instructions for use of acetylsalicylic acid, tablets are taken after meals. You can drink the drug not only with plain water, but also with alkaline mineral water, as well as with milk.

The dosage is determined by the doctor. If it is not possible to see a doctor and the problem is not significant, you can take aspirin in the amount of 1-2 tablets, which corresponds to 500-1000 mg. The dose is indicated for an adult. 3-4 doses of medication are allowed per day.

Is it possible to use 2 tablets of acetylsalicylic acid 4 times a day? It is prohibited to use the medicine in such quantities. The maximum daily dose corresponds to 6 tablets. You can be treated with the drug for no longer than two weeks.

Effect on blood clotting

Acetylsalicylic acid thins the blood. To find out how to take tablets to improve the rheological properties of blood, you should consult a doctor. The specialist will select an individual dosage. To prevent platelet aggregation, the drug is used in an amount of 0.5 tablets/day. The course duration is usually 2-3 months.

Myocardial infarction

To prevent myocardial infarction, use 250 mg of the drug per day. For thromboembolism and cerebrovascular accidents, 0.5 tablets/day is also used. Gradually the amount of the drug is increased to 1000 mg (2 tablets/day).

Instructions for the use of Acetylsalicylic acid for fever in children and adults

Aspirin is usually prescribed for colds.

Tablets for fever should not be used on an empty stomach. If you need to bring down the temperature of an adult, the recommended dosage is 250-1000 mg of the drug. You can take the medicine 3 or 4 times a day.

For fever, children are given from 100 to 300 mg of the drug. It is advisable that the dose of the medication be selected by a doctor. The dosage size for children is determined according to age.

To kid over two years old give 100 mg of medicine.
From three years old 150 mg is allowed.
When treating a child over four years old it is necessary to use 200 mg of the drug, and when treating a child of age over five years old– 250 mg.
Acetylsalicylic acid in the recommended amount can be given to a child 3 or 4 times a day.

For headaches

Acetylsalicylic acid is an effective remedy for headaches. You can also take Paracetamol. The drug is potent, so it can either benefit the body or harm it. When determining the appropriate dose of the drug, you should be as careful as possible. If rest is not planned in the near future, take two tablets. If after taking the drug it is possible to sleep or relax, the dose of the drug should be reduced to 0.5-1 tablet. To obtain the desired effect, the medication must be taken immediately after the onset of discomfort.

The indicated doses of the medicine are intended for use by adults. This treatment option is not suitable for children.

Hangover

Regardless of the reasons for the development of headaches, it is possible to effectively solve the problem. For example, in everyday life people often take the drug for a hangover. But we should not forget that the medication only eliminates the pain, but not the hangover itself. To get rid of the problem, use other medications when you have a hangover.

How does aspirin affect blood pressure?

Does aspirin increase or decrease blood pressure? The medication does not affect blood pressure in any way. The ability of the drug to eliminate migraine pain and reduce intracranial pressure is explained by its ability to thin the blood. Using the drug for hypertension is harmful due to the risk of bleeding.

Treatment for menstruation and toothache

Can the product be used during menstruation? In such cases, you can use the drug, but with caution and obtaining prior consultation with a doctor. The recommended dose is 1 tablet 2 times a day, but it is still better to use other painkillers for these purposes - analgin, spasmalgon, no-shpu.

Aspirin also helps against toothache, as it can have a pronounced analgesic effect. But you cannot use more than 4000 mg of the product per day. Otherwise, severe damage to the brain and internal organs may occur. Children under 12 years of age should choose other medications, as should pregnant women. When a toothache occurs, Paracetamol will also help.

How to get rid of acne

The drug helps get rid of acne. It acts quickly and is one of the most effective remedies. Acetylsalicylic acid, when used on the face, destroys bacteria, which helps stop the inflammatory process and dry the skin. For treatment, the tablet must be dissolved in water and the liquid used for wiping. The solution is applied pointwise, directly to pimples.

Masks

A face mask with honey promotes healthy skin. For 3-4 tablets, honey and water in the amount of 1 tsp are required. and 5 drops respectively. A paste is prepared from these components and applied for a quarter of an hour. The remaining product is washed off with warm water.
A mask with acetylsalicylic acid for acne may also contain other ingredients, for example, black clay. The component is prepared in the amount of several tablespoons, diluted with water to obtain a homogeneous mass. Then the last and main ingredient is added - Acetylsalicylic acid in powder form (1 tablet per 1 tablespoon of clay). Cover the face with the prepared gruel for 20 minutes, then wash off with cool water.

If you decide to use acetylsalicylic acid to fight acne, do not forget that the courses should be short, otherwise you can dry out the skin. If you have dry skin, be careful when choosing this acne treatment method.

Acetylsalicylic acid is suitable for the face in cases where the skin is oily

Before using masks, make sure that the body's reaction to the effects of the components is normal. Otherwise there is a risk of irritation. When searching for a product with acetylsalicylic acid for acne, reviews will help you make the most correct choice.

Acetylsalicylic acid for hair

Aspirin has a beneficial effect on hair follicles. A drug:

restores shine;
eliminates the consequences of unsuccessful staining;
Lightens undyed hair naturally;
increases volume;
accelerates the growth process;
neutralizes the negative effects of chlorine when visiting the pool;
eliminates electrification and alopecia.

However, not everyone can use aspirin for hair restoration and not always. You can’t make compresses and masks often. When used externally, the main component of the product penetrates well through tissue. Aspirin for hair can be used from the age of 12, since with earlier use there is a high risk of Reye's syndrome. For those who have eczema, psoriasis or seborrhea sicca, as well as those with sensitive skin, care based on the use of Acetylsalicylic acid is not suitable.

Easy to use: dissolve 2-3 tablets in warm water and add to any hair mask.

Carrying a child, lactation

During pregnancy, it is strictly forbidden to use Acetylsalicylic acid. A nursing mother should also not use the medicine. The medication is not prescribed to pregnant women due to the harmful substances it contains.

Aspirin and alcohol

It is important to know how to take medicine so as not to harm your body.

Are acetylsalicylic acid and alcohol compatible?

With their simultaneous use, the mucous membrane of the digestive tract is irritated, which can provoke the development of allergies, the appearance of ulcers and intragastric bleeding, the occurrence of a stroke, a heart attack. Possible death.

You should take the medicine before drinking alcohol. Using it a day in advance will reduce the severity of your hangover.

Combination with caffeine

Caffeine can be used with the drug. However, there are contraindications, so you should consult your doctor.

Best before date

The shelf life of the medicine is 2 years. The product should be stored at room temperature in a place where light and moisture do not penetrate, children and animals do not have access.

What acetylsalicylic acid is, what it helps with and how to take it is indicated in the instructions for use. It is especially important to consult a doctor when treating children. For young patients, the drug can be very dangerous.

Acidum acetylsalicylicum Analogs

(generics, synonyms)

Acetylsalicylic acid

Rp.: Tab. “Aspirinum” No. 10

Recipe

D.S. 1/4 tab. 1 r/d n/n

D. No. 10 in tab.

S.: 1 tablet each. 3-4 times a day after meals.

S.: 1/4 tab. 1 r/d n/n
NSAIDs; has anti-inflammatory, analgesic and antipyretic effects associated with indiscriminate inhibition of the activity of COX1 and COX2, which regulate the synthesis of Pg. As a result, Pg is not formed, which ensures the formation of edema and hyperalgesia.

A decrease in Pg content (mainly E1) in the thermoregulation center leads to a decrease in body temperature due to dilation of skin vessels and increased sweating.

The analgesic effect is due to both central and peripheral effects. Reduces platelet aggregation, adhesion and thrombus formation by suppressing the synthesis of thromboxane A2 in platelets.

The antiplatelet effect persists for 7 days after a single dose (more pronounced in men than in women). Reduces mortality and the risk of developing myocardial infarction in unstable angina.
Effective in the primary prevention of cardiovascular diseases, especially myocardial infarction in men over 40 years of age, and in the secondary prevention of myocardial infarction. In a daily dose of 6 g or more, it suppresses prothrombin synthesis in the liver and increases prothrombin time.

Stimulates the excretion of uric acid (impairs its reabsorption in the renal tubules), but in high doses. Blockade of COX1 in the gastric mucosa leads to inhibition of gastroprotective Pg, which can cause ulceration of the mucous membrane and subsequent bleeding.
Dosage forms containing buffer substances, enteric coating, as well as special “effervescent” forms of tablets have a lesser irritating effect on the gastrointestinal mucosa.

The analgesic effect of acetylsalicylic acid is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Due to a decrease in the production of prostaglandins, their effect on thermoregulation centers decreases. An irreversible disruption of the synthesis of thromboxane A2 in platelets causes the antiplatelet effect of acetylsalicylic acid. In high doses, acetylsalicylic acid inhibits prothrombin synthesis in the liver and increases prothrombin time.

Soluble tablets: orally, after dissolving in a small amount of water, 400-800 mg 2-3 times a day (no more than 6 g).

For acute rheumatism - 100 mg/kg/day in 5-6 divided doses.

Orally, for fever and pain in adults - 0.5-1 g/day (up to 3 g), divided into 3 doses.
The duration of treatment should not exceed 2 weeks. Effervescent tablets are dissolved in 100-200 ml of water and taken orally, after meals, a single dose is 0.25-1 g, taken 3-4 times a day.
The duration of treatment ranges from a single dose to a multi-month course.
To improve the rheological properties of blood - 0.15-0.25 g/day for several months.

For myocardial infarction, as well as for secondary prevention in patients who have had a myocardial infarction, 40-325 mg once a day (usually 160 mg). As an inhibitor of platelet aggregation - 300-325 mg/day for a long time.

For dynamic cerebrovascular accidents in men, cerebral thromboembolism - 325 mg/day with a gradual increase to a maximum of 1 g/day, for the prevention of relapses - 125-300 mg/day.

For the prevention of thrombosis or occlusion of the aortic shunt - 325 mg every 7 hours through an intranasally inserted gastric tube, then orally - 325 mg 3 times a day (usually in combination with dipyridamole, which is discontinued after a week, continuing long-term treatment with ASA).

For active rheumatism, it was prescribed (not currently prescribed) in a daily dose of 5-8 g for adults and 100-125 mg/kg for adolescents (15-18 years); frequency of use - 4-5 times a day. After 1-2 weeks of treatment for children, reduce the dose to 60-70 mg/kg/day, treatment for adults is continued at the same dose; Duration of treatment - up to 6 weeks. Cancellation is carried out gradually over 1-2 weeks.

The duration of treatment (without consulting a doctor) should not exceed 5 days when prescribed as an analgesic and more than 3 days when prescribed as an antipyretic.

Rheumatism, rheumatoid arthritis, infectious-allergic myocarditis, pericarditis, rheumatic chorea - not currently used.

Feverish syndrome in infectious and inflammatory diseases. Pain syndrome (of various origins): headache (including those associated with alcohol withdrawal syndrome), migraine, toothache, neuralgia, lumbago, thoracic radicular syndrome, myalgia, arthralgia, algodismenorrhea.

As an antiplatelet drug (doses up to 300 mg/day): IHD, the presence of several risk factors for IHD,
silent myocardial ischemia,
unstable angina,
myocardial infarction (to reduce the risk of recurrent myocardial infarction and death after myocardial infarction),
repeated transient cerebral ischemia and ischemic stroke in men,
heart valve replacement (prevention and treatment of thromboembolism),
balloon coronary angioplasty and stent placement (reducing the risk of re-stenosis and treating secondary coronary artery dissection),
for non-atherosclerotic lesions of the coronary artery (Kawasaki disease),
aortoarteritis (Takayasu disease),
valvular mitral heart defects and atrial fibrillation,
mitral valve prolapse (prevention of thromboembolism),
recurrent pulmonary embolism,
pulmonary infarction, acute thrombophlebitis,
Dressler's syndrome.

In clinical immunology and allergology: in gradually increasing doses for long-term “aspirin” desensitization and the formation of stable tolerance to NSAIDs in patients with “aspirin” asthma and the “aspirin triad”.

- elevated temperature (fever) with influenza, colds (ARVI) and other infectious and inflammatory diseases.

Hypersensitivity;

erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding;
“aspirin” triad (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to ASA and pyrazolone-type drugs);
hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);
dissecting aortic aneurysm, portal hypertension; vitamin K deficiency;
liver/renal failure;
pregnancy (I and III trimesters), lactation period; deficiency of glucose-6-phosphate dehydrogenase, childhood (under 15 years of age - the risk of developing Reye's syndrome in children with hyperthermia due to viral diseases).

With caution:
Hyperuricemia, urate nephrourolithiasis, gout, liver disease, gastric ulcer and/or duodenal ulcer (history), decompensated CHF.

Side effects

Nausea, loss of appetite, gastralgia, diarrhea; allergic reactions (skin rash, angioedema, bronchospasm);
impaired liver and/or kidney function;
thrombocytopenia, anemia, leukopenia, Reye's syndrome (encephalopathy and acute fatty liver with rapid development of liver failure),
formation based on the hapten mechanism of “aspirin” asthma and the “aspirin triad” (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to ASA and pyrazolone-type drugs).

With long-term use - dizziness, headache, vomiting, erosive and ulcerative lesions of the gastrointestinal tract, hypocoagulation, bleeding (including in the gastrointestinal tract);
visual impairment, decreased hearing acuity, tinnitus, bronchospasm, interstitial nephritis, prerenal azotemia with increased creatinine in the blood and hypercalcemia, papillary necrosis, acute renal failure, nephrotic syndrome, aseptic meningitis, increased symptoms of CHF, edema, increased activity of the liver "transaminases.

Overdose.
Symptoms (single dose less than 150 mg/kg - acute poisoning is considered mild, 150-300 mg/kg - moderate, more than 300 mg/kg - severe): salicylic syndrome (nausea, vomiting, tinnitus, blurred vision, dizziness, severe headache, general malaise, fever - a poor prognostic sign in adults).

Severe poisoning - hyperventilation of the lungs of central origin, respiratory alkalosis, metabolic acidosis, confusion, drowsiness, collapse, convulsions, anuria, bleeding.

Initially, central hyperventilation of the lungs leads to respiratory alkalosis - shortness of breath, suffocation, cyanosis, cold sticky sweat; with increasing intoxication, respiratory paralysis and uncoupling of oxidative phosphorylation increase, causing respiratory acidosis.

In chronic overdose, the concentration determined in plasma does not correlate well with the severity of intoxication.

The greatest risk of developing chronic intoxication is observed in elderly people when taking more than 100 mg/kg/day for several days.

In children and elderly patients, the initial signs of salicylicism are not always noticeable, so it is advisable to periodically determine the concentration of salicylates in the blood: a level above 70 mg% indicates moderate or severe poisoning; above 100 mg% - extremely severe, prognostically unfavorable.

Moderate poisoning requires hospitalization for 24 hours.

Treatment: provocation of vomiting, administration of activated carbon and laxatives, constant monitoring of CBS and electrolyte balance; depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate solution or sodium lactate.

Increasing reserve alkalinity enhances the excretion of ASA due to alkalinization of urine.
Alkalinization of urine is indicated when the level of salicylates is above 40 mg% and is provided by intravenous infusion of sodium bicarbonate (88 mEq in 1 liter of 5% dextrose solution, at a rate of 10-15 ml/h/kg); restoration of bcc and induction of diuresis is achieved by administering sodium bicarbonate in the same doses and dilution, which is repeated 2-3 times.

Caution should be exercised in elderly patients in whom intensive fluid infusion may lead to pulmonary edema. The use of acetazolamide for alkalinization of urine is not recommended (it can cause acidemia and enhance the toxic effect of salicylates).
Hemodialysis is indicated when the salicylate level is more than 100-130 mg%, in patients with chronic poisoning - 40 mg% or lower if indicated (refractory acidosis, progressive deterioration, severe central nervous system damage, pulmonary edema and renal failure).

For pulmonary edema - mechanical ventilation with an oxygen-enriched mixture.

Release form

Tablets, tablets [for children], enteric-coated tablets, film-coated tablets, effervescent tablets

ATTENTION!

Registration number:
P N003627/01

Tradename:
Acetylsalicylic acid.

MNI or group name:
Acetylsalicylic acid.

Dosage form:
Pills.

Composition per tablet:
Active substance:

Acetylsalicylic acid - 500 mg

Excipients:

Potato starch - 91 mg
Talc - 9 mg

Description:
The tablets are white, slightly marbled, flat-cylindrical in shape with a chamfer and a score.

Pharmacotherapeutic group:
Non-steroidal anti-inflammatory drug (NSAID).

ATX code:
N02BA01

Pharmacological properties:
The drug has an analgesic, antipyretic, and anti-inflammatory effect, which is due to the inhibition of cyclooxygenases involved in the synthesis of prostaglandins. Acetylsalicylic acid inhibits platelet aggregation by blocking the synthesis of thromboxane A2.

Pharmacokinetics:
When taken orally, absorption is complete. During absorption, it undergoes presystemic elimination in the intestinal wall and in the liver (deacetylated). The absorbed part is quickly hydrolyzed by nonspecific plasma cholinesterases and albuminesterase, so the half-life is no more than 15-20 minutes. It circulates in the body (75 - 90% in connection with albumin) and is distributed in tissues in the form of salicylic acid anion. Time to reach maximum concentration is 2 hours. Serum concentration of salicylates is highly variable. Salicylates easily penetrate many tissues and body fluids, incl. into the cerebrospinal, peritoneal and synovial fluids. Penetration into the joint cavity accelerates in the presence of hyperemia and edema and slows down in the proliferative phase of inflammation. Salicylates are found in small quantities in nervous tissue, traces in bile, sweat, and feces. When acidosis occurs, most of the salicylic acid is converted into non-ionized acid, which penetrates well into tissues, incl. into the brain. It quickly passes through the placenta and is excreted in small quantities in breast milk. Metabolized primarily in the liver. Metabolites of acetylsalicylic and salicylic acids are the glycine conjugant of salicylic acid, gentisic
acid and its glycine conjugant. It is excreted primarily by active secretion in the renal tubules in the form of salicylic acid (60%) and in the form of metabolites. The excretion of salicylic acid depends on the pH of the urine (with alkalinization of the urine, the ionization of salicylates increases, their reabsorption worsens and excretion increases significantly). The rate of elimination depends on the dose: when taking small doses, the half-life is 2-3 hours, with increasing doses it can increase to 15-30 hours.

Indications for use:
Treatment of moderate or mild pain: headache (including withdrawal symptoms), toothache, sore throat, back and muscle pain, joint pain, menstrual pain. Increased body temperature during colds and other infectious and inflammatory diseases (in adults and children over 15 years of age).

Contraindications:

Hypersensitivity to acetylsalicylic acid and other NSAIDs or other components of the drug;
Erosive and ulcerative lesions of the gastrointestinal tract (GIT) (in the acute phase);
Gastrointestinal bleeding;
Hemorrhagic diathesis;
Concomitant use of methotrexate at a dose of 15 mg per week or more;
Complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid;
Bronchial asthma induced by taking salicylates and other NSAIDs;
Pregnancy (I and III trimester), breastfeeding period;
Children's age (up to 15 years - when used as an antipyretic). The drug is not prescribed to children under 15 years of age with acute respiratory diseases caused by viral infections due to the risk of developing Reye's syndrome (encephalopathy and acute fatty liver with acute development of liver failure).

Carefully:
With concomitant therapy with anticoagulants, gout, gastric ulcer and/or duodenal ulcer (history), including chronic or recurrent peptic ulcer, or episodes of gastrointestinal bleeding; with renal and/or liver failure, glucose-6-phosphate dehydrogenase deficiency; hyperuricemia, bronchial asthma, chronic obstructive pulmonary disease, hay fever, nasal polyposis, drug allergies, concomitant use of methotrexate at a dose of less than 15 mg/week, pregnancy (II trimester).

Use during pregnancy and lactation:
During pregnancy, the use of the drug is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Directions for use and dosage:
Orally, adults and children over 12 years of age: single dose is 250-500 mg, maximum single dose is 1.0 g (2 tablets of 500 mg), maximum daily dose is 3.0 g (6 tablets of 500 mg), single dose if necessary, you can take 3-4 times a day with an interval of at least 4 hours.
Children (as an analgesic) aged 6 to 12 years, with the exception of acute respiratory diseases caused by viral infections, due to the risk of developing Reye's syndrome (encephalopathy and acute fatty liver with acute development of liver failure), a single dose is 250 mg per dose, take up to 3 times a day.

Mode of application:
The drug should be taken after meals with water, milk or alkaline mineral water.

Frequency and time of reception:
If necessary, a single dose can be taken 3-4 times a day with an interval of at least 4 hours.
Regular adherence to the drug regimen allows you to avoid a sharp increase in temperature and reduce the intensity of pain.
The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic and more than 3 days when prescribed as an antipyretic.

Side effect:
From the gastrointestinal tract:
Decreased appetite, abdominal pain, heartburn, nausea, vomiting, obvious (vomiting with blood, tarry stools) or hidden signs of gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive and ulcerative lesions (including perforation) of the gastrointestinal tract. intestinal tract, isolated cases of liver dysfunction (increased liver transaminases), diarrhea.
From the central nervous system:
Dizziness, tinnitus (usually signs of overdose); with long-term use - headache, blurred vision, decreased hearing acuity, aseptic meningitis.
From the cardiovascular system:
With long-term use - increased symptoms of chronic heart failure.
From the hematopoietic system:
Increased risk of bleeding, which is a consequence of the effect of acetylsalicylic acid on platelet aggregation, thrombocytopenia, anemia, leukopenia.
From the excretory system:
Renal dysfunction; with long-term use - interstitial nephritis, prerenal azotemia with increased creatinine levels in the blood and hypercalcemia, papillary necrosis, acute renal failure, nephrotic syndrome, edema.
Allergic reactions:
Skin rash, anaphylactic reactions, bronchospasm, Quincke's edema. Reye's syndrome (encephalopathy and acute fatty liver with rapid development of liver failure).
If such symptoms appear, it is recommended to stop taking the drug and immediately consult your doctor.

Overdose:
Symptoms:
Moderate overdose:
Nausea, vomiting, tinnitus, hearing loss, headache, dizziness and confusion. These symptoms disappear when the dose is reduced or the drug is discontinued.
Severe overdose:
Fever, hyperventilation, ketoacidosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycemia.
In chronic overdose, the concentration determined in plasma does not correlate well with the severity of intoxication. The greatest risk of developing chronic intoxication is observed in elderly people when taking more than 100 mg/kg/day for several days. In children and elderly patients, the initial signs of salicylicism are not always noticeable, so it is advisable to periodically determine the concentration of salicylates in the blood: a concentration above 70 mg% indicates moderate or severe poisoning; above 100 mg% - extremely severe, prognostically unfavorable.
For moderate to severe poisoning, hospitalization is required.

Treatment:
Hospitalization, gastric lavage, activated charcoal, monitoring of acid-base balance, alkalinization of urine in order to obtain a urine pH between 7.5 - 8 (forced alkaline diuresis is considered achieved if the concentration of salicylate in the blood plasma is no more than 500 mg/l (3.6 mmol/l) in adults or 300 mg/l (2.2 mmol/l) in children), hemodialysis, replacement of fluid loss, symptomatic therapy. Caution should be exercised in elderly patients in whom intensive fluid infusion may lead to pulmonary edema. The use of acetazolamide for alkalinization of urine is not recommended (it can cause acidosis and enhance the toxic effect of salicylates). Hemodialysis is indicated when the concentration of salicylates is more than 100 - 130 mg%, in patients with chronic poisoning - 40 mg% and lower if indicated (refractory acidosis, progressive deterioration, severe damage to the central nervous system, pulmonary edema and renal failure). For pulmonary edema, artificial ventilation of the lungs with an oxygen-enriched mixture.

Interaction with other drugs:
Combined use:

With methotrexate at a dose of 15 mg per week or more is a contraindication: the hemolytic cytotoxicity of methotrexate increases (renal clearance of methotrexate decreases and methotrexate is replaced by salicylates in connection with blood plasma proteins);
With anticoagulants, for example, heparin: the risk of bleeding increases due to impaired platelet function, damage to the mucous membrane of the gastrointestinal tract, displacement of anticoagulants (indirect) from connection with blood plasma proteins;
With other non-steroidal anti-inflammatory drugs: as a result of synergistic interaction, the risk of ulcers and bleeding from the stomach and duodenum increases;
With uricosuric drugs, for example, benzbromarone: reduces the uricosuric effect;
With digoxin: diogoxin concentration increases due to decreased renal excretion;
With hypoglycemic drugs: the hypoglycemic effect of hypoglycemic drugs increases due to the hypoglycemic effect of acetylsalicylic acid;
With drugs of the thrombolytic group: the fibrinolytic effect of the latter is enhanced and the risk of bleeding increases;
With glucocorticosteroids, excluding hydrocortisone, used as replacement therapy for Addison's disease: when using glucocorticosteroids, the concentration of salicelates in the blood decreases due to increased excretion of the latter;
With angiotensin-converting enzyme inhibitors: glomerular filtration is reduced due to inhibition of prostaglandin synthesis and, as a result, the antihypertensive effect is reduced;
With valproic acid: the toxicity of valproic acid increases;
With glucocorticosteroids, ethanol (alcoholic beverages) and ethanol-containing drugs: the risk of damaging the mucous membrane of the gastrointestinal tract increases, the risk of developing gastrointestinal bleeding increases;
Enhances the effects of narcotic analgesics, indirect anticoagulants and antiplatelet agents, sulfonamides (including co-trimoxazole - increases their activity and toxicity), triiodothyronine (increases the activity and increases the risk of side effects of the latter);
Reduces the effect of antihypertensive drugs, diuretics (spironolactone, furosemide);
Increases the concentration of barbiturates and lithium salts in plasma;
Antacids containing magnesium and/or aluminum slow down and impair the absorption of acetylsalicylic acid;
Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Special instructions:
Acetylsalicylic acid may cause bronchospasm, an attack of bronchial asthma or other hypersensitivity reactions. Risk factors are the presence of bronchial asthma, nasal polyps, fever, chronic bronchopulmonary diseases, and a history of allergies (allergic rhinitis, skin rashes).
Acetylsalicylic acid may increase the tendency to bleeding, which is associated with its inhibitory effect on platelet aggregation. This should be taken into account when surgical interventions are necessary, including minor interventions such as tooth extraction. Before surgery, to reduce bleeding during surgery and in the postoperative period, you should stop taking the drug 5-7 days in advance and notify the doctor.
Children should not be prescribed medications containing acetylsalicylic acid, since in the case of a viral infection the risk of Reye's syndrome increases. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, and liver enlargement. Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. There was no effect of taking the drug on driving a vehicle or other mechanisms, which may affect the ability to drive vehicles, etc.
Acetylsalicylic acid has a teratogenic effect; when used in the first trimester, it leads to the development of cleft palate; in the third trimester it causes inhibition of labor (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the pulmonary circulation. It is excreted in breast milk, which increases the risk of bleeding in the baby due to impaired platelet function.
During the treatment period, you should refrain from taking ethanol.

Release form:
Tablets 500 mg.
10 tablets per blister-free or blister pack. One or two blister packs along with instructions for use are placed in a box made of cardboard. Contour cellless packages, together with an equal number of instructions for use, are placed in a group package.

Storage conditions:
Store in a dry place, protected from light, at a temperature not exceeding 25 °C.
Keep out of the reach of children.

Best before date:
4 years. Do not use the drug after the expiration date.

Conditions for dispensing from pharmacies:
Over the counter.