Polyoxidonium lyophilisate instructions for use. Purpose and special instructions

Immunostimulating drug

Preparation: POLYOXIDONIUM ®

Active substance: azoximer bromide
ATX code: L03AX
KFG: Immunostimulating drug
ICD-10 codes (indications): A15, A60, B00, B02, I83.2, J00, J01, J03, J04, J06.9, J10, J30.1, J31, J32, J35.0, J37, J45, K63, L20.8, L30. 3, M05, N10, N11, N30, N34, N41, N70, N71, N72, T14, T30, Z29.8
Reg. number: P N002935/02
Registration date: 10.10.08
Owner reg. cred.: NPO PETROVAX PHARM (Russia)

DOSAGE FORM, COMPOSITION AND PACKAGING

Excipients:

4.5 mg - glass ampoules (5) - cardboard packs.
4.5 mg - glass ampoules (5) - contour blister packs (1) - cardboard packs.
4.5 mg - glass ampoules (5) complete with solvent (0.9% sodium solution chloride - amp. 5 pcs.) - cardboard packs.

Lyophilisate for the preparation of solution for injection and local application in the form of a porous mass from white with a yellowish tint to yellow; the drug is hygroscopic and photosensitive.

Excipients: mannitol, povidone, betacarotene.

4.5 mg - glass bottles (5) - cardboard packs.
4.5 mg - glass bottles (5) - contour cell packaging (1) - cardboard packs.
4.5 mg - glass bottles (5) complete with solvent (0.9% sodium chloride solution - amp. 5 pcs.) - cardboard packs.

Lyophilisate for the preparation of solution for injection and topical use in the form of a porous mass from white with a yellowish tint to yellow; the drug is hygroscopic and photosensitive.

Excipients: mannitol, povidone, betacarotene.

9 mg - glass ampoules (5) - cardboard packs.
9 mg - glass ampoules (5) - contour blister packs (1) - cardboard packs.
9 mg - glass ampoules (5) complete with solvent (0.9% sodium chloride solution - amp. 5 pcs.) - cardboard packs.

Lyophilisate for the preparation of solution for injection and topical use in the form of a porous mass from white with a yellowish tint to yellow; the drug is hygroscopic and photosensitive.

Excipients: mannitol, povidone, betacarotene.

9 mg - glass bottles (5) - cardboard packs.
9 mg - glass bottles (5) - contour cell packaging (1) - cardboard packs.
9 mg - glass bottles (5) complete with solvent (0.9% sodium chloride solution - amp. 5 pcs.) - cardboard packs.

INSTRUCTIONS FOR USE FOR SPECIALISTS.
The description of the drug was approved by the manufacturer in 2013.

PHARMACOLOGICAL ACTION

Immunomodulatory drug.

Polyoxidonium ® has an immunomodulatory effect, increases the body's resistance to local and generalized infections. The basis of the mechanism of immunomodulatory action of the drug Polyoxidonium ® is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation.

Polyoxidonium ® restores immunity in case of secondary immunodeficiency states caused by various infections, injuries, burns, autoimmune diseases, malignant neoplasms, complications after surgical operations, the use of chemotherapeutic agents, cytostatics, steroid hormones.

Along with immunomodulatory effects. Polyoxidonium has pronounced detoxifying and antioxidant activity, has the ability to remove toxins and salts from the body heavy metals, inhibits lipid peroxidation. These properties are determined by the structure and high-molecular nature of the drug Polyoxidonium ®. Its inclusion in complex therapy of cancer patients reduces intoxication due to chemotherapy and radiation therapy, in most cases allows for standard therapy without changing the regimen due to the development infectious complications and side effects (myelosuppression, vomiting, diarrhea, cystitis, colitis and others).

The use of the drug Polyoxidonium ® against the background of secondary immunodeficiency states can increase the effectiveness and shorten the duration of treatment, significantly reduce the use of antibiotics, bronchodilators, corticosteroids, and extend the period of remission.

The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.

PHARMACOKINETICS

Suction

The bioavailability of the drug when administered intramuscularly is 89%. After intramuscular administration, the time to reach Cmax in blood plasma is 40 minutes.

Distribution

Quickly distributed in all organs and tissues. Half-life of distribution in the body ( fast phase) is 0.44 hours.

Metabolism and excretion

In the body, the drug is hydrolyzed to oligomers, which are excreted primarily by the kidneys.

T 1/2 ( slow phase) is - 36.2 hours.

INDICATIONS

Correction of immunity in adults and children from 6 months.

In adults in complex therapy:

Chronic recurrent infectious diseases inflammatory diseases, not amenable to standard therapy in the acute stage and in remission;

Acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);

Tuberculosis;

Acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infection;

In oncology during and after chemotherapy and radiation therapy to reduce immunosuppressive, nephro- and hepatotoxicity toxic effect medicines;

To activate regenerative processes (fractures, burns, trophic ulcers);

Rheumatoid arthritis, long-term treatment with immunosuppressants;

In cases of rheumatoid arthritis complicated by acute respiratory infections;

For the prevention of postoperative infectious complications;

For the prevention of influenza and acute respiratory infections.

In children in complex therapy:

Acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy pharyngeal tonsil, ARVI);

Acute allergic and toxic-allergic conditions;

Bronchial asthma complicated by chronic respiratory tract infections;

Atopic dermatitis complicated by purulent infection;

Intestinal dysbiosis (in combination with specific therapy);

For the rehabilitation of those who are often and long-term ill;

Prevention of influenza and acute respiratory infections.

DOSING REGIME

The drug is administered parenterally and intranasally. The dose and route of administration are determined by the doctor depending on the diagnosis, severity of the disease, and age of the patient.

Adults

IM or IV (drip)

The drug is prescribed intramuscularly or intravenously (drip) to adults in doses of 6-12 mg 1 time/day daily, every other day, or 1-2 times a week, depending on the diagnosis and severity of the disease.

At the drug is prescribed at a dose of 6 mg daily for 3 days, then every other day, general course- 5-10 injections.

At

At tuberculosis prescribed in a dose of 6-12 mg 2 times a week, course - 10-20 injections.

At acute and chronic urogenital diseases prescribed at a dose of 6 mg every other day, course - 10 injections in combination with chemotherapy.

At chronic recurrent herpes- at a dose of 6 mg every other day, course - 10 injections in combination with antiviral drugs, interferons and inducers of interferon synthesis.

For prescribed at a dose of 6 mg, course - 5 injections (the first two injections daily, then every other day).

At the drug is administered intravenously at 6-12 mg in combination with antiallergic drugs.

At rheumatoid arthritis prescribed at a dose of 6 mg every other day, 5 injections are given, then 2 times a week, the course is at least 10 injections.

Before and in the background chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents the drug is prescribed in a dose of 6-12 mg every other day, the course is at least 10 injections; further, the frequency of administration is determined by the doctor depending on the tolerability and duration of chemotherapy and radiation therapy.

For prevention immunosuppressive effect, conditioned tumor process, and for correction of immunodeficiency after chemotherapy and radiation therapy, after surgical removal tumors the drug is prescribed in a dose of 6-12 mg 1-2 times a week, indicated long-term use(from 2-3 months to 1 year).

Patients withacute renal failure the drug is prescribed no more than 2 times a week.

For cooking solution for intramuscular administration the contents of the 6 mg ampoule or bottle are dissolved in 1.5-2 ml of 0.9% sodium chloride solution or water for injection.

For cooking solution for intravenous (drip) administration the contents of the 6 mg ampoule or bottle are dissolved in 2 ml of 0.9% sodium chloride solution, hemodez-N, rheopolyglucin or 5% dextrose solution, then, under sterile conditions, transferred into a bottle with the indicated solutions with a volume of 200-400 ml.

Prepared solution for parenteral administration cannot be stored.

Intranasally

For treatment of acute and chronic infectious diseases of the ENT organs, strengthening the regenerative processes of the mucous membranes, prevention of complications and relapses of diseases, prevention of influenza and acute respiratory infections Prescribe 3 drops in each nasal passage with an interval of 2-3 hours (3 times/day) for 5-10 days.

Rules for preparing a solution for topical use

For cooking solution for local (intranasal) use 6 mg of lyophilisate is dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water room temperature.

Children

The drug is administered parenterally, intranasally, sublingually. The dose and route of administration are determined by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.

IM or IV (drip)

Parenterally, the drug is prescribed to children from 6 months at a dose of 3 mg (im or intravenous drip at a dose of 100-150 mcg/kg) daily, every other day or 2 times a week for a course of 5-10 injections.

At acute inflammatory diseases the drug is prescribed at a dose of 100 mcg/kg every other day, the course is 5-7 injections.

At chronic inflammatory diseases the drug is prescribed at a dose of 150 mcg/kg 2 times a week, the course is up to 10 injections.

At acute allergic and toxic allergic conditions the drug is administered intravenously at a dose of 150 mcg/kg in combination with antiallergic drugs.

For treatment of complicated forms of allergic diseases in combination with basic therapy, the drug is administered intramuscularly at a dose of 100 mcg/kg with an interval of 1-2 days, the course is 5 injections.

Rules for preparing solutions for injections

For cooking solution for intramuscular administration the contents of an ampoule or vial of 3 mg are dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.

For cooking solution for intravenous administration the contents of the 3 mg ampoule or bottle are dissolved in 1.5-2 ml of a sterile 0.9% solution of sodium chloride, rheopolyglucin, hemodez-N or 5% dextrose solution, and under sterile conditions transferred into a bottle with the indicated solutions with a volume of 150-250 ml.

Intranasally and with ublingually

Daily at a daily dose of 150 mcg/kg for 5-10 days. The solution is administered 1-3 drops into one nasal passage or under the tongue after 2-3 hours.

The drug is administered intranasally, 1-3 drops into one nasal passage every 2-3 hours (2-4 times/day).

Sublingually for all indications - daily at a daily dose of 0.15 mg/kg for 10 days, for the treatment of intestinal dysbiosis - for 10-20 days. Place 1-3 drops under the tongue after 2-3 hours.

For intramuscular and sublingual administration calculation daily dose For children presented in the table.

Rules for preparing a solution for intranasal and sublingual use

To prepare the solution, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg is dissolved in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. One drop of the prepared solution (50 μl) contains 150 μg of azoximer bromide, which is prescribed per 1 kg of child’s body weight.

The solution for intranasal and sublingual use should be stored in the refrigerator for no more than 7 days. Before use, the pipette with the solution must be warmed to room temperature (20-25°C).

SIDE EFFECTS

Local reactions: pain at the injection site with intramuscular injection.

CONTRAINDICATIONS

Pregnancy ( clinical experience no application);

Lactation (no clinical experience of use);

Individual increased sensitivity to the drug.

WITH caution The drug should be prescribed for acute renal failure, as well as for children under 6 months of age (clinical experience is limited).

PREGNANCY AND LACTATION

The drug is contraindicated for use during pregnancy and lactation (clinical experience of use is limited).

SPECIAL INSTRUCTIONS

If there is pain at the injection site during intramuscular administration, the drug is dissolved in 1 ml of 0.25% procaine solution if the patient does not have increased individual sensitivity to procaine.

When administered intravenously (drip), it should not be dissolved in protein-containing infusion solutions.

OVERDOSE

Currently, no cases of overdose of the drug Polyoxidonium ® have been reported.

DRUG INTERACTIONS

Polyoxidonium ® is compatible with antibiotics, antiviral, antifungal and antihistamines, bronchodilators, corticosteroids, cytostatics.

CONDITIONS OF VACATION FROM PHARMACIES

The drug is available with a prescription.

CONDITIONS AND DURATION OF STORAGE

List B. Lyophilisate for the preparation of solution for injection and topical use should be stored in a dry place, protected from light, out of reach of children, at a temperature of 4° to 8°C. Shelf life - 2 years.

The drug Polyoxidonium is an effective and high-quality immune stimulant, the main purpose of which, based on pharmacological action, is to raise the level of immunity.

This drug greatly increases the degree of resistance of an adult, as well as child's body To various infections, successfully copes with the consequences of immunodeficiency.

In this article we will look at why doctors prescribe Polyoxidonium, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS People who have already used Polyoxidonium can be read in the comments.

Composition and release form

The tablets are flat-cylindrical, each of them has a chamfer. Their color can vary from yellowish-white to orange-yellow. The presence of slightly noticeable particles of more intense color is allowed in tablets.

One tablet of Polyoxidonium contains 12 mg active substance, and also potato starch(Amylum solani), lactose monohydrate (Lactose monohydrate), stearic acid (Acidum stearicum) as auxiliary components.

Clinical and pharmacological group: immunostimulating drug.

What does Polyoxidonium help with?

In adults and children over 6 years of age in complex therapy to correct immune deficiency:

• to activate regenerative processes (fractures, burns, trophic ulcers);
• for the rehabilitation of frequently and long-term (more than 4-5 times a year) ill persons;
• during and after chemotherapy and radiation therapy of tumors;
• various forms of tuberculosis;
• allergic diseases complicated by recurrent bacterial and viral infection (including hay fever, bronchial asthma, atopic dermatitis);
• rheumatoid arthritis treated for a long time with immunosuppressants; with rheumatoid arthritis complicated by acute respiratory infections or acute respiratory viral infections;
• chronic recurrent inflammatory diseases of any etiology that are not amenable to standard therapy, both in the acute stage and in the remission stage;
• acute and chronic viral and bacterial infections, including urethritis, cystitis, pyelonephritis in the latent stage and in the acute stage, prostatitis, chronic salpingoophoritis, endometritis, colpitis, diseases caused by the papilloma virus, cervical ectopia, dysplasia, leukoplakia;
• to reduce the nephro- and hepatotoxic effects of drugs.

As monotherapy:

• for the prevention of recurrent herpetic infection;
• for the correction of secondary immunodeficiencies resulting from aging or exposure to unfavorable factors;
• For seasonal prevention exacerbations of chronic foci of infections, including in the elderly;
• for the prevention of influenza and acute respiratory infections.

Pharmacological action

Polyoxidonium is a drug that has immunomodulatory and detoxification properties. Increases the body's resistance to various infectious diseases.

He is able to normalize immune status at severe forms immunodeficiency, including secondary immunodeficiency, due to damage by ionizing radiation, during treatment with hormones and cytostatics, after operations, severe injuries, burns and malignant tumors.

Reduces toxicity medications and various toxic substances, increasing sustainability cell membranes to the cytotoxic effect of these substances.

Instructions for use

According to the instructions for use, Polyoxidonium tablets can be swallowed without chewing, and then washed down a large number still water, preferably 30 minutes before meals, and you can eat 1 hour after taking it.

• Prevention of ARVI in frequently ill patients - 2 tablets 2 times a day - 10-15 days.
• Chronic diseases of the upper and lower respiratory tract - 2 tablets (24 mg) 2 times a day for 10-14 days.
• Prevention of respiratory diseases (flu, ARVI) during the epidemic period - 2 tablets 2 times a day for 10 to 15 days.
• Viral, fungal, bacterial diseases, difficult to treat - 1 tablet 2/day for 15 days.
• Frequent exacerbations of chronic diseases affecting the nose, ear and throat - 1 tablet 2 times a day for 10 days.
• Maintenance therapy for tuberculosis, oncological diseases, immunodeficiency - 1 tablet 2 times a day for up to 12 months.

The duration of administration and dose of the drug in some cases can be changed after the conclusions of the doctors treating the patient, which will necessarily take into account the patient’s age, presence concomitant diseases, the severity of their course, the state of immunity.

Contraindications

This drug is contraindicated for use in people with hypersensitivity to the components included in its composition. The use of Polyoxidonium is not recommended for women during pregnancy and lactation, with renal failure and age under 6 months are sufficient factors to prohibit the use of this drug.

Side effects

The main side effect of using suppositories and tablets can be considered hypersensitivity reactions. In some patients with intramuscular use medication, there is pain at the injection site and redness. After the first few injections of the drug, an increase in body temperature may be observed.

Analogues

Analogs of Polyoxidonium according to the mechanism of action are: Galavit Bestim Anaferon Arpetolide Glutoxim Isofon Imudon Actinolysate Immunal Gerbion Vitanam Deoxynate Broncho-Vaxom Poludan Timalin Methyluracil Immunex Wobenzym Arpeflu Imunofan Cycloferon Erbisol Ribomunil Ruzam Estifan Stemokin Flogenzym Engistol Echinacea and some other medicines.

Prices

The average price of POLYOXIDONIUM in pharmacies (Moscow) is 700 rubles.

1. Ira

   We tested polyoxidonium in tablets and suppositories. I took the pills myself and gave suppositories to the children. And last year’s flu and all sorts of viruses slipped through. This year I have already purchased the drug, there is no rush for such products yet. They usually become more expensive in winter.

   I’m encouraging my sister to buy it and start drinking it, she’s having a bad reaction to antibiotics, so better prevention carry out in advance. She laughs at the title) But the fact that she often gets sick is not funny at all. I've been sick since childhood, but my immune system is weak.

2. Raisa

   The drug is a dummy and not cheap. I got sick with the flu and was advised to inject polyoxidonium in addition to treatment with other drugs. I was sick for 10 days, no less than always. And the disease was difficult. But after I was cured, exactly 10 days later I fell ill again, this has never happened before. This is a natural pacifier, and there are probably a lot of side effects. It seems to me that, on the contrary, it weakened my immunity. I have never been so sick twice in a month. And don’t lie to people about the benefits of this drug for the immune system.

3. Catherine

   Whatever the infection, my husband and I will definitely “catch” it. I'm so tired of constant illnesses. Friends advised me to drink polyoxidonium simply for preventive purposes. For the first time in many months, the spring cold did not affect us. And it was so opportune - we were just leaving on vacation. I can advise everyone who has the same weakened immune system. We're holding on for now. I hope it will last for a long time.

4. Valery

   My wife and I are not supporters of treatment with pills, but we have learned from our own experience that sometimes there is no other way. We tried to find the most harmless medicines. But those that seem harmless act worse than any antibiotics. We searched for a long time, and this winter we found a medicine that helped us quickly cope with the flu and recover from the virus. Polyoxidonium is convenient to drink - you just dissolve it and that’s it. We asked doctors - the reviews are good, even children can drink it. We are planning to take a course for prevention. Autumn is coming, which means it's time to come colds. Let's try not to get sick.

5. Kate

   I don't know what I would do without polyoxidonium. I look at the other children in the kindergarten: they are always covered in snot, coughing non-stop... Do parents really like to look at this? For example, I switched to it a long time ago and don’t regret it at all. I know 100 percent that my child will not catch the infection. At least it’s not scary to leave it in the garden all day! And everyone who is afraid to use it has long wanted to let them read the latest research.

6. Lolly

   I've been suffering since I was little in different forms allergopathology, so finding a cure, even for a common flu, is very difficult. Many instructions say that the medicine can be used in patients with allergies, but in fact this turns out to be a lie. No such incidents arose with polyoxidonium. Naturally, I was scared to take another drug, but I wanted to find normal pills so much that I took a risk. And not in vain, as I can now judge. She cured the flu without consequences, and did not notice any negative after-effects. I’m also pleased, of course, that my immunity has improved. I haven't been sick at all this year.

7. Renata

   I always take Polycosidonium with me on trips. I rarely get sick at home, but when I go somewhere, I immediately get a cold with high temperature. These tablets are suitable for both me and my husband, so I know for sure that I can buy a pack and carry it with me just in case. If we do catch a cold, polyoxidonium helps us get back on our feet quickly. The disease passes almost unnoticed, and most importantly, without complications.

8. Oxy

   When complications arise during ARVI, it takes a very serious turn. This happened to me for the first time last winter. Now it’s difficult to assess what helped more and what less, but polyoxidonium is responsible for the fact that I began to feel better after a couple of days. Thank God, this medicine can be administered at any stage of the disease. Of the 3 weeks of non-stop treatment, only the last 7 days, when I took a course of pills, was able to get out of bed and do things around the house. It took quite a bit of time to recover, but I was cured without complications or consequences. Polyoxidonium suited me. The next stage is that I’m going to drink it for preventive purposes in the fall. I want to boost my immunity.

9. Larisa

   This fall I already managed to get sick. But less than a week and I was already at work. I think I caught it in time. Weekend and 2 more days stuck on time off - bed rest, tea, honey, gargling, tablets (including polyoxidonium). Last time I took it every year for prevention, but this year I did not expect that viruses would come to us so early. But polyoxidonium pulled me out of my illness quite quickly, considering that on the first day my temperature was quite high. We must not forget to take a preventive course before winter.

10. Tatiana

    I somehow had to take polyoxidonium as prescribed by a doctor. The effect is excellent. I was very sick then, then I quickly recovered, and after completing the course I fell ill with ARVI only in April. And all winter, when our office went on sick leave, I was like a cucumber, neither sneezed nor coughed.

11. Miroslava

    The main principle of polyoxidonium is the rapid activation of the immune system, which is expressed in the production of interferon. Polyoxide begins to work within three hours after taking it, i.e. after three hours, your interferon begins to fight viruses. Due to this, recovery is faster. I have been using this drug for two years now when I start getting sick with ARVI. The effectiveness is noticeable already on the second day - you feel better, the fever stops, and the temperature drops. By the way, this comes from the fact that polyoxidonium, in addition to activating the immune system, removes viral toxins.

12. Natalia

    After we completed the course of polyoxidonium, my son began to get sick much less often in kindergarten. For the past year he has been sick almost every month. But this year, since the beginning of September, I got sick only once, and then I wasn’t sick for very long, about five days.

13. Silvia

    A friend once told me about polyoxidonium. This drug was prescribed to her daughter when she fell ill with ARVI and then complications arose. I remember this, and I remembered it when my son got sick. Our pediatrician confirmed that this is good antiviral drug and that if you follow the scheme, he will get his son back on his feet in just a couple of days. It was hard to believe, after all, these were just pills, not a magic powder))) But they really worked, and if I was used to treating a child for weeks, then everything went away in less than a week. Result? Result.

    15.12.2018

    Well, of course, everyone likes their own way of fighting ARVI; for some, polyoxidonium may help, but for me it doesn’t. That’s why I take Ingavirin, it makes recovery much faster.

Azoximer bromide has complex action: immunomodulatory, detoxifying, antioxidant, moderate anti-inflammatory.

The basis of the mechanism of immunomodulatory action of Azoximer bromide is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation and the synthesis of interferon-alpha and interferon-gamma.

Detoxification and antioxidant properties Azoximer bromide is largely determined by the structure and high-molecular nature of the drug.

Azoximer bromide increases the body's resistance to local and generalized infections of bacterial, fungal and viral etiology. Restores immunity in secondary immunodeficiency conditions caused by various infections, injuries, complications after surgical operations.

A characteristic feature of Azoximer bromide when applied topically (sublingually) is the ability to activate factors of the body's early defense against infection: the drug stimulates the bactericidal properties of neutrophils, macrophages, enhances their ability to absorb bacteria, increases the bactericidal properties of saliva and secretions of the mucous membranes of the upper respiratory tract.

At oral administration Azoximer bromide also activates lymphoid cells in lymph nodes intestines.

Azoximer bromide blocks soluble toxic substances and microparticles, has the ability to remove toxins, heavy metal salts from the body, inhibits lipid peroxidation, both by intercepting free radicals, and through the elimination of catalytically active Fe2+ ions. Azoximer bromide reduces inflammatory reaction by normalizing the synthesis of pro- and anti-inflammatory cytokines.

Azoximer bromide is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.

Azoximer bromide is odorless and tasteless, and does not have a local irritating effect when applied to the mucous membranes of the nose and oropharynx.

Pharmacokinetics

Azoximer bromide after oral administration is quickly absorbed from the gastrointestinal tract, the bioavailability of the drug is oral administration more than 70%. The maximum concentration in blood plasma is achieved 3 hours after ingestion. The pharmacokinetics of Azoximer bromide is linear (plasma concentration is proportional to the dose taken).

Azoximer bromide is a hydrophilic compound. The apparent volume of distribution is approximately 0.5 l/kg, which indicates that the drug is distributed mainly in the interstitial fluid. The half-life of absorption is 35 minutes, the half-life is 18 hours.

Azoximer bromide is quickly distributed throughout all organs and tissues of the body, penetrates the blood-brain and blood-ophthalmic barriers. There is no cumulative effect. In the body of Azoximer, bromide undergoes biodegradation to low molecular weight oligomers, is excreted mainly by the kidneys, with feces - no more than 3%.

Release form

Tablets from white with a yellowish tint to yellow with an orange tint, flat-cylindrical, chamfered, with a score on one side and the inscription “PO” on the other side; The presence of barely noticeable inclusions of more intense color is allowed.

Excipients: mannitol, povidone, betacarotene, lactose monohydrate, potato starch, stearic acid.

10 pcs. - contour cellular packaging (1) - cardboard packs.

Dosage

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Orally and sublingually 20-30 minutes before meals daily, 2 times a day: children over 10 years old and adults - 1 tablet, children from 3 to 10 years old - ½ tablet (6 mg).

If necessary, it is possible to carry out repeat courses therapy after 3-4 months. When the drug is re-prescribed, its effectiveness does not decrease.

Sublingual:

For treatment in adults:

flu and acute respiratory infections– 1 tablet 2 times a day for 7 days; inflammatory processes of the oropharynx - 1 tablet 2 times a day for 10 days; exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis– 1 tablet 2 times a day for 10 days; allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 10 days.

For treatment in children aged 3 to 10 years:

influenza and acute respiratory infections – ½ tablet 2 times a day for 7 days; inflammatory processes of the oropharynx – ½ tablet 2 times a day for 7 days; allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - ½ tablet 2 times a day for 7 days.

influenza and acute respiratory infections - 1 tablet 2 times a day for 7 days; inflammatory processes of the oropharynx - 1 tablet 2 times a day for 7 days; exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis media - 1 tablet 2 times a day for 7 days; allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 7 days.

For prevention in adults:

influenza and acute respiratory infections in the pre-epidemic period - 1 tablet per day for 10 days; recurrent herpetic infection of the nasal and labial area - 1 tablet 2 times a day for 10 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - 1 tablet once a day for 10 days; secondary immunodeficiencies arising due to aging or exposure to adverse factors - 1 tablet once a day for 10 days.

For prevention in children aged 3 to 10 years:

Influenza and acute respiratory infections in the pre-epidemic period - ½ tablet per day for 7 days; recurrent herpetic infection of the nasal and labial area - ½ tablet 2 times a day for 7 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - ½ tablet once a day for 10 days.

For prevention in children over 10 years of age:

influenza and acute respiratory infections in the pre-epidemic period - 1 tablet per day for 7 days; recurrent herpetic infection of the nasal and labial area - 1 tablet 2 times a day for 7 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear, 1 tablet once a day for 10 days.

Orally

For treatment in adults:

For treatment in children over 10 years of age:

diseases of the upper and lower respiratory tract - 1 tablet 2 times 10 days.

Interaction

Azoximer bromide does not inhibit the isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, cytochrome P-450, therefore the drug is compatible with antibiotics, antiviral, antifungal and antihistamines, glucocorticosteroids and cytostatics.

If you are taking the above or other medicines(including over-the-counter medications), consult your doctor before taking Polyoxidonium.

Side effects

No side effects have been reported. If you notice any side effects, not listed in the instructions, please inform your doctor.

Indications

Treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology) that are not amenable to standard therapy in adults and adolescents over 12 years of age, both in the acute and remission stages.

As part of complex therapy:

• acute and chronic infectious and inflammatory diseases of the oropharynx, paranasal sinuses, upper sections respiratory tract, inner and middle ear;
• allergic diseases complicated by recurrent bacterial, fungal and viral infections (including hay fever, bronchial asthma);
• for the rehabilitation of frequently and long-term (more than 4-5 times a year) ill persons.

As monotherapy:

• prevention of recurrent herpes infection;
• seasonal prevention of exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;
• in immunocompromised individuals for the prevention of influenza and other acute respiratory infections in the pre-epidemic period;
• for the correction of secondary immunodeficiencies resulting from aging or exposure to adverse factors.

Contraindications

increased individual sensitivity; pregnancy, period breastfeeding; children under 3 years of age; acute renal failure; rare hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.

Features of application

Use during pregnancy and breastfeeding

The use of the drug Polyoxidonium® is contraindicated for pregnant women and women during breastfeeding (there is no clinical experience of use).

Experimental use of the drug Polyoxidonium® in animals did not reveal embryotoxic or teratogenic effects or effects on fetal development.

Before using Polyoxidonium®, if you are pregnant, or think you might be pregnant, or are planning a pregnancy, you should consult your doctor.

During breastfeeding, you should consult your doctor before using Polyoxidonium®.

About caution

If you have the diseases listed in this section, consult your doctor before starting to take the drug: chronic renal failure (used no more than 2 times a week).

• General spectrum of action and secondary immunodeficiency
• Types and dosage
• Indications
  • Pills
  • Lyophilisate
  • Suppositories (rectal, vaginal)
• Special instructions
  • Product form: tablets
  • Product form - lyophilisate
  • Candles
• More information
• Analogues and contraindications
• Side effects, compatibility and storage conditions

The drug Polyoxidonium is an effective and high-quality immune stimulant, the main purpose of which, based on its pharmacological action, is to increase the level of immunity. This medicine greatly increases the resistance of adults and children to various infections and successfully copes with the consequences of immunodeficiency. The most effective common form of the drug is Polyoxidonium injections, which are intravenous and intramuscular injections. Other types of medicine are also produced - these are suppositories and tablets.

General spectrum of action and secondary immunodeficiency

Polyoxidonium injections are universal remedy to eliminate complex secondary immunodeficiency. Thanks to this property, the medication is prescribed as an effective therapeutic medicine in order to eliminate the recurrent consequences of advanced chronic diseases of the lungs, hearing organs, diseases of the urogenital tract, etc. In addition, the drug is prescribed to complex application as an active element in the treatment of a wide range of diseases: cancer, tuberculosis, allergies, intestinal dysbiosis, arthritis, ulcers.

With the help of Polyoxidonium injections, it is possible to restore inhibited immune reactions at the regenerative stage after injuries or burns, the manifestation of malignant neoplasms, as well as the use of chemotherapy. Injections of this remedy are indispensable for complications identified after surgery. In fact, the medication effectively reduces the toxicity of medications and chemical components taken, further increasing the resistance of cells to the aggressive actions of various substances that destroy the structure of the cell membrane.

Using Polyoxidonium injections prescribed as part of a whole therapeutic complex, the effectiveness of treatment is significantly increased, coupled with a reduction in its duration. The need to use powerful antibiotics, glucocorticosteroids, and medications used to relieve bronchospasm practically disappears. The remission period increases.

Polyoxidonium is well tolerated by adults and children and does not stimulate the occurrence of allergic reactions, does not change the structure of DNA, does not increase the risks of development cancer diseases. Can the medication be used by pregnant women? Yes, but only after professional advice. The drug definitely cannot cause a mutation in the fetus or its abnormal development.

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Types and dosage

Prescribed for use following forms Polyoxidonium:

• rectal, as well as vaginal suppositories, or, in other words, suppositories consisting of 6 and 12 mg of the substance;
• tablets containing exactly 12 mg of active substance;
• powder for creating a solution used exclusively in injections, drops (3 and 6 mg) - lyophilisate.

More details about the dose medicine can be found in the instructions for the individual forms.

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Indications

In practice, the range of indications for the use of the device is quite extensive and multifaceted.

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Pills

• therapy of complex chronic infections occurring in respiratory tract, hearing organs, oral cavity and sinuses;
• preventive processes of ARVI, especially during the epidemiological period of influenza.

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Lyophilisate

• various long-term infectious diseases, often chronic;
• cancer prevention during different periods radiation technique, chemotherapy;
• allergic reactions, especially bronchial asthma, dermatitis;
• prevention of tuberculosis, arthritis, herpes;
• damage to ligaments and bone tissue;
• getting burns;
• prevention of secondary HIV infection.

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Suppositories (rectal, vaginal)

• various types of inflammatory diseases;
• sexual dysfunction;
• bladder inflammation;
• gynecological practice: leukoplakia, inflammation of the uterine mucosa, disease fallopian tubes, vaginitis, cervical dysplasia;
• papillomas and other skin diseases;
• tumor therapy;
• infectious diseases, their prevention (different age range).

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Special instructions

After the injection of the device, there is a possibility of pain at the injection sites, especially after intramuscular injection. As for the question of an overdose of the device, it is simply impossible, based on the very nature of the drug.

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Product form: tablets

Instructions for using the device Polyoxidonium tablets:

• minor children over 12 years old - 1 pill, maximum 1-3 times a day (the dose directly depends on the severity of the disease);
• adults are recommended to consume up to 2 tablets, 1-3 times a day.

Take before meals, 45 minutes. It is necessary to swallow the medication without chewing or dissolving.

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Product form: lyophilisate

Instructions for using the medication in solution:

• IM injections, IV drips: to prepare a solution, you need to dilute 1.5 ml of powder from an ampoule with 3 ml of solution;
• The daily dose of injections is 6 mg. The treatment method depends on the type of disease and its degree. During drip administration the injection is performed together with the solution, with a dosage of 200-400 ml. As a rule, a single course of treatment includes at least 10 appointments.
• Ratio: 100-150 mcg per kg of body weight is applicable to the age of 6 months.

The use of lyophilisate is contraindicated if:

• symptoms of allergy to components;
• pregnancy, breastfeeding;
• acute kidney failure;
• the child's age is less than 6 months.

Name:

Polyoxidonium

Pharmacological action:

Polyoxidonium is a drug with immunomodulatory and detoxification properties. Increases the body's resistance to various infectious diseases. Under its influence, killer cells and the phagocytic function of the blood are activated. Antibody formation increases. It is able to normalize the immune status in severe forms of immunodeficiency, including secondary immunodeficiency, due to damage by ionizing radiation, during treatment with hormones and cytostatics, after surgery, severe injuries, burns and malignant tumors. Reduces the toxicity of medications and various toxic substances, increasing the resistance of cell membranes to the cytotoxic effects of these substances. Polyoxidonium is not mutagenic, allergenic, teratogenic or carcinogenic effect. Polyoxidonium works most effectively in combination with traditional therapy diseases.

Indications for use:

Polyoxidonium is used in combination with the main therapy in the treatment of chronic recurrent infectious diseases that are difficult to respond to traditional treatment,

For acute and chronic bacterial and viral diseases,

chronic allergic diseases such as bronchial asthma, eczema, neurodermatitis, atopic dermatitis, hay fever, complicated bacterial infection,

Local and generalized purulent-septic diseases, postoperative complications in surgical patients,

Polyoxidonium is used after radiation and chemotherapy in the treatment of patients with cancer,

To reduce the toxic effect of medications on the kidneys and liver,

To activate regenerative processes in fractures, burns, trophic ulcers,

In joint therapy of rheumatism, rheumatoid arthritis,

For tuberculosis of various localizations,

For acute and chronic infections genitourinary system, both in men and women (prostatitis, urethritis, pyelonephritis, cystitis, endometritis, salpingo-oophoritis, ectopia, erosion, dysplasia and leukoplakia of the cervix, viral diseases),

For HIV infection,

In children older than six months, Polyoxdonium is used as part of the main therapy for the following diseases:

Chronic and acute infectious diseases caused by viral, bacterial or fungal pathogens,

Acute and chronic allergic diseases complicated by bacterial infection (atopic dermatitis, neurodermatitis, eczema, bronchial asthma),

Intestinal dysbiosis.

Method of application:

For adults, polyoxidonium is used intramuscularly and intravenously in a dose of 6-12 g, once a day, every other day, or 1-2 times a week, depending on the ethology of the disease and the severity of the patient’s condition. For intramuscular administration, the contents of the bottle or ampoule are dissolved in 2-3 ml of distilled water or in an isotonic sodium chloride solution. Polyoxidonium injection solution cannot be stored. For intravenous drip administration, the contents of the bottle or ampoule are dissolved in 2-3 ml of saline. solution or isotonic solution of dextran and, under aseptic conditions, is introduced into an appropriate bottle with a volume of 200-400 ml.

For acute infectious diseases together with the main antibacterial therapy Polyoxidonium is prescribed for intramuscular or intravenous administration, 6 mg once a day for the first three days, then 6 mg once a day, every other day, for a total of 5-10 injections per day. full course treatment. At chronic diseases 6 mg every day, 5 injections, then 2 times a week, for a course of 10 injections. For tuberculosis infection, 6 mg, twice a week, 10-20 injections of polyoxidonium for the full course of treatment. At malignant neoplasms before and after chemotherapy, 12 mg of polyoxidonium every other day, the full course of treatment is 10 injections.

Vaginally, polyoxidonium is used in conjunction with the main treatment for diseases of the genitourinary system, 1 suppository (12 mg) once a day for 3 days, then every day. The full course of treatment is 10 suppositories. Inserted deep into the vagina in a lying position. After administration, it is recommended not to get up for 1 hour, so they should be used at night.

For acute infectious diseases in children, the drug is administered intramuscularly or intravenously at a dose of 0.1-0.15 mg/1 kg of child’s body weight once a day, every 12 hours. For a full course of treatment - 5-7 injections (for chronic diseases, the doses do not change, but the drug is used 2 times a week). Polyxidonium can also be prescribed to children sublingually or intranasally (3-5 drops in each nasal passage once a day). To do this, you need to dissolve 3 g of Polyoxidonium in 1 ml of distilled water. In acute allergic conditions, polyoxidonium is used intravenously at a dose of 0.1 g per 1 kg of body weight, together with antihistamines.

Adverse events:

Polyoxidonium is usually well tolerated, but sometimes there is pain when intramuscular injection at the site of drug administration. Also, hypersensitivity to this drug is very rare.

Contraindications:

Interaction with other drugs:

Polyoxidonium combines well with antibacterial, antiviral, antiallergic and antifungal drugs, also with glucocorticosteroids, bronchodilators, cytostatics.

Overdose:

Cases of drug overdose have not been described.

Release form of the drug:

Lyophilized porous mass in vials or ampoules, for the preparation of solution for injection.

Polyoxidonium suppositories, 10 pcs. in packaging.

Storage conditions:

Keep out of reach of children when temperature conditions from 4 to 15 °C.

Store the solution for intranasal and sublingual use in the refrigerator for no more than a day. Solution for intramuscular and intravenous administration cannot be stored.

Compound:

1 ampoule or bottle of the drug contains - polyoxidonium 3 or 6 mg.

1 suppository of the drug contains - polyoxidonium 3 mg, 6 mg or 12 mg.

Drugs with similar effects:

ADT-anatoxinum / ADT-M-anatoxinum Derinat (solution for external use) (Derinat) Derinat (solution for injection) (Derinat) Licopid (Licopid) Neovir (Neovir)

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