For what disease is the medicine zirgan used? Side effects and contraindications

Healthy eyes for a person it is stability of life. After all, it is thanks to his healthy vision we can contemplate the beauty of the world around us, do our work, indulge in hobbies.

However, not everyone today can boast full health eye. The reasons for this may be hereditary factors or acquired, which manifest themselves due to the impact on human body various bacteria and viruses.

Many are associated with viral infections, which adversely affect both the shell of the eyes - the eyelids, and the internal contents. Today, many ophthalmologist patients complain of itching around the eyes, small rash, pain, profuse lacrimation. These symptoms may occur simultaneously during the progression of a disease such as herpes, called superficial keratitis.

IN medical practice ophthalmologists use large number drugs against of this disease and as a preventive measure. Among the most effective in terms of effective influence on ocular herpes Specialists especially highlight the eye gel "Zirgan". The drug used can be of French or Italian origin.

Description of the drug and its properties

Eye gel "Zirgan" is available in a five-gram tube with a tip closed with a plastic cap. The drug is packaged in a cardboard box with the manufacturer’s logos.

Eye gel "Zirgan" contains ganciclovir, benzalkonium chloride, carbomer, sorbitol, sodium hydroxide, purified water.

Such chemical composition is able to actively destroy viral cells, introducing itself into their DNA and disrupting the sequential chain of their development.

The drug "Zirgan" requires careful use; it should not come into contact with the skin, as well as soft contact lenses. Medicine is placed several times a day in the lower area according to the instructions and prescriptions of the attending physician. It is allowed to use Zirgan eye gel for twenty-one days.

After opening the tube with the contents, the shelf life of the drug is four weeks.

The drug is not intended for treatment cytomegalovirus infections retina of the eye. The eye gel is not recommended for use in children under twelve years of age, pregnant or breastfeeding mothers.

To all men and women childbearing age It is recommended to use methods of reliable contraception, since the drug has a very negative effect on the development of the embryo.

Side effects

Studies of medical eye gel revealed the following possible side effects: intolerance to the components contained in the composition, development of arrhythmia, manifestation of hepatitis, dry mucous membranes oral cavity, irritability, drowsiness, chills, dizziness, back and lower back pain, blurred vision, conjunctivitis.

"Characteristic: Compound
eye gel ZIRGAN
1 g:
- ganciclovir 1.5 mg;
Excipients: benzalkonium chloride, carbomer, sorbitol, sodium hydroxide, purified water.
Pharmgroup: Antiviral drugs.
Pharmaceutical action: Ganciclovir 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine or DHPG is a nucleoside that inhibits the replication of herpes group viruses ( herpes simplex first and second types, cytomegalovirus) and adenoviruses of such serotypes 1, 2, 4, 6, 8, 10, 19, 22, 28.
In infected cells, ganciclovir is converted to ganciclovir triphosphate - active form active substance. Phosphorylation occurs predominantly in infected cells, and the concentration of ganciclovir triphosphate in uninfected cells is 10 times lower.
The antiviral activity of ganciclovir triphosphate consists of inhibition of viral DNA synthesis through two mechanisms: competitive inhibition of viral DNA polymerase and direct incorporation into viral DNA, blocking its extension.
Pharmacokinetics: In people after ophthalmic use drug ZIRGAN 5 times a day for 11-15 days for the treatment of superficial herpetic keratitis, plasma ganciclovir levels determined using a sensitive analytical method (quantitative cutoff: 0.005 μg/ml) were very low: on average 0.013 μg/ml (0 = 0.037).
Indications: Treatment of acute superficial keratitis caused by the herpes simplex virus.
Contraindications: Hypersensitivity to ganciclovir, acyclovir or any component of ZIRGAN.
The period of pregnancy and lactation.
Childhood.
Dosage: Instill 1 drop into the lower conjunctival sac of the affected eye 5 times a day until complete re-epithelialization of the cornea, then 1 drop 3 times a day for 7 days.
The duration of treatment should not exceed 21 days.
Side effect: From the side of the organ of vision:
- very often (> 1/10) - a transient feeling of burning or tingling in the eye;
- often (> 1/100,<1/10) - поверхностный крапчатый кератит.
Special instructions: ZIRGAN is not intended for the treatment of cytomegalovirus infection of the retina.
Effectiveness against keratoconjunctivitis caused by other types of viruses has not been established.
No specific studies have been conducted in patients with immunodeficiency.
During therapy and for three months after completion of treatment, women of childbearing age must use contraception.
Due to genotoxicity detected in animal experiments, men who use ZIRGAN eye gel are advised to use local contraceptives (condoms) during and for three months after the end of treatment.
Benzalkonium chloride may cause eye irritation and discoloration of soft contact lenses. Avoid contact of the drug with soft contact lenses. Before using the drug, it is recommended to remove contact lenses and reinsert them no earlier than 15 minutes after instillation.
Use during pregnancy or breastfeeding.
ZIRGAN is not recommended for use during pregnancy or breastfeeding.
Children.
The drug is not recommended for use in children.
The ability to influence the reaction rate when driving vehicles or other mechanisms. Due to possible visual impairment during treatment with ZIRGAN, you should not drive a car or operate machinery. "

No analogues were found for this product.

Discount!

DYNAMO. Not Vital and Essential Drugs

For owners of an electronic membership card "Dynamo" - 5% discount for assortment not subject to state price regulation (not vital and essential drugs)

ROSPROFZHEL. Not vital drugs.

For owners of an electronic union card of a member of ROSPROFZHEL - 5% discount

Details about the program: www.rpz-card.ru

YOLKA. Not vital drugs.

For owners of the electronic student card ЕLKA - 5% discount for an assortment that is not subject to state price regulation (not vital and essential drugs).

In most cases, acyclovir or other antiviral drugs can be used as an analogue. Before purchasing an analogue, read its instructions.

There is an injectable form - cymevene.

Price

Average online price*: 891 rub.

acute superficial keratitis;
conjunctivitis.

Please note that ganciclovir gel dosage form is not initially intended for the treatment of cytomegalovirus infection of the retina. Although this fact does not exclude the possibility of use under strict medical supervision.

Despite the effectiveness of the substance ganciclovir (this is the main component of this medication), the medicine should be taken only in consultation with your doctor. Self-diagnosis is often erroneous, and the reaction to Ganciclovir in most cases is individual.

Directions for use and doses

Zirgan ophthalmic antiviral gel is used as follows:

the first phase lasts until complete re-epithelialization of the cornea;
in the first phase of treatment, the dose is 5 times a day, 1 drop;
instillation is carried out carefully, into the lower conjunctival sac of the affected eye, while carefully turning away the edge;
the second phase lasts 7 days;
in the second phase, the dose is 3 times 1 drop;
the general course of treatment is 21 days;
Extending the duration of the treatment course is not recommended.

Contraindications

When using the drug Zirgan, a number of contraindications should be taken into account:

individual intolerance to acyclovir, ganciclovir and any individual component (hypersensitivity can lead to allergic reactions);
age of children under 12 years old;
lactation period;
state of pregnancy.

It should be noted that:

The drug fights the herpes virus and its consequences. Conjunctivitis and keratitis due to other viruses cannot be treated with Zirgan;
Patients with known immunodeficiency should not be treated with this drug on their own. No studies have been conducted on this subject, and there are no data from the manufacturer.

Experiments are inappropriate. To undergo an accurate diagnosis, be sure to visit a doctor (ophthalmologist, immunologist, virologist).

Other precautions:

It is unacceptable to use Ganciclovir eye gel while working with complex instruments and equipment, as well as while driving (the drug can affect concentration);
Contact of the drug with soft contact lenses is contraindicated (they must be removed from the eyes, and installed after instillation of the drug Zirgan no earlier than 15 minutes);
the drug is genotoxic, so people of childbearing age after completing the course of treatment must follow the rules of local contraception for 3 months (especially if a possible pregnancy is desired).

Pregnancy and lactation

Zirgan is not recommended for women during pregnancy and breastfeeding. In extreme cases, the issue is resolved individually with a competent doctor.

Side effects

The most common side effects are:

conjunctival hyperemia;
burning sensation in the eye of a transient nature;
superficial speckled (point) keratitis;
tingling in the eye;
irritation of the mucous membrane of the affected eye;
temporary blurred vision;

Attention! Most often, side effects occur due to excessive abuse of the drug Zirgan or due to individual intolerance. Contact your doctor immediately to decide whether to continue using Ganciclovir or discontinue it.

Composition and pharmacokinetics

This drug is a topical antiviral drug. Designed specifically to solve ophthalmic problems. Composition of the medicine:

the main active substance is the component Ganciclovir (1.5 mg/1 g of Zirgan eye gel);
excipients - purified water, sorbitol, benzalkonium chloride, sodium hydroxide, carbomer.

The active substance ganciclovir allows you to inhibit the replication of the human herpes simplex virus (both types 1 and 2). According to the results of monitoring patients, after the first 10-15 days of treatment of superficial keratitis with the drug Zirgan, superficial herpetic lesions are significantly reduced.

Other

What else you need to know about the drug ZIRGAN®:

packaging - 5 g tube;
store in places out of reach of children;
storage temperature no higher than 25 degrees;
when sealed, shelf life is 3 years;
after opening the tube, use the Zirgan preparation within 4 weeks (dispose of the unused remainder);
the distributor in the Russian Federation is JSC Santen (Moscow);
produced by Farmila-Thea Pharmaceutici S.p.A (Italy);
holder of the Certificate of Registration of Laboratories Thea (France).

For diseases of the visual organs, ointments, drops and other topical medications are used. "Zirgan" is an eye gel with antiviral properties. The composition of the drug includes elements that are capable of attacking viral cells in a short period of time, destroying them. Before using the medicine, you should consult an ophthalmologist.

Composition and properties

Eye gel "Zirgan" ("Virgan") is a medication that has an antiviral effect that can fight Herpes Simplex, Epstein-Barr, and Varicella Zoster viruses.
The active component is ganciclovir - an element that is similar in structure to acyclovir and is a synthetic analogue of guanine. The medicine is produced in plastic tubes, 5 g each, equipped with dispensers in the form of tips and stands for proper storage of the medicine in the original packaging. Auxiliary components are:
sorbitol;
benzalkonium;
water;
carbomer, etc.

The action of the drug is aimed at eliminating the virus.
Ganciclovir is a nucleoside. It can inhibit the replication of human herpes simplex viruses types I and II. Upon penetration into diseased areas, the cells transform the active component to its active state - ganciclovir triphosphate. Activity against viruses consists of the ability to inhibit the synthesis of viral DNA polymerase with subsequent inclusion in the pathogen gene and the effect on chain termination, which prevents its replication. As a result, the ability to reproduce is stopped and herpes does not spread in the body, but is transferred to a latent form. Thanks to the auxiliary components, the gel acquires the necessary consistency, is successfully released during use and is able to fight viruses.

Indications
Zirgan eye gel is used to treat acute superficial keratitis caused by the herpes simplex virus, accompanied by the following symptoms:
blepharospasm - narrowing of the eye slit;
photophobia;
itching in the eye area;
feeling of a foreign body;
lacrimation;
cutting pain in the eye.

Contraindications

A person may not tolerate the drug due to his own characteristics.
The drug "Zirgan" should not be used in the following situations:
personal intolerance to ganciclovir;
period of pregnancy, lactation;
therapy for cytomegalovirus infections of the ocular retina;
age up to 12 years.

In case of immunodeficiency, the drug should be used with extreme caution. During pregnancy and breastfeeding, Zirgan should not be used. Experiments have shown that this drug is characterized by genotoxicity. As a result, all people in reproductive condition must take this fact into account when using the medication and for the next 3 months after therapy. During this period, proven contraceptives must be used.

Instructions for use
Zirgan gel is available only by prescription, so before using it you must consult an ophthalmologist. Instructions for use indicate that the medication is administered into the area of the lower conjunctival sac, 1 drop up to 5 times a day. Therapy must be carried out until the cornea is completely restored. In the next 7 days, this ointment should be administered three times a day, 1 drop. The total duration of the course of therapy is up to 3 weeks.
When treating with Zirgan gel, it is advisable to drink a lot of fluids to speed up the elimination of all components of this drug from the body.