Medicinal reference book geotar. Sulfadimethoxine: what does this antibiotic help with, how often to use, analogues
Sulfadimethoxine- a broad-spectrum antibacterial agent with a bacteriostatic effect.
Sulfadimethoxine, being a chemical structure analogue of para-aminobenzoic acid, interferes with its absorption and disrupts biosynthetic processes in bacterial cells. Inhibits the growth and reproduction of gram-positive and gram-negative bacteria, including anaerobes. Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae); gram-negative bacteria: Klebsiella pneumoniae, Escherichia coli, Shigella spp. Active against Chlamydia trachomatis.
The antimicrobial effect of sulfadimethoxine is significantly weakened in the presence of pus and tissue breakdown products.
Pharmacokinetics
.When taken orally, it is relatively slowly absorbed from the gastrointestinal tract; detected in the blood after 30 minutes. The maximum concentration in the blood is achieved after 8-12 hours. The required therapeutic concentration in the blood (in adults) when taking 1-2 g is noted on the first day, maintenance doses (0.5-1 g) provide a therapeutic level in the blood throughout the course of treatment .
Penetrates well into tissues and body fluids, including pleural effusion, peritoneal and synovial fluids, middle ear exudate, chamber moisture, and tissues of the genitourinary tract. Penetrates through the placenta and into breast milk. Weakly penetrates the blood-brain barrier.
Metabolism occurs primarily in the liver by microsomal glucuronidation. It is excreted in the form of metabolites, mainly by the kidneys, as well as with bile.
Indications for use
Preparation Sulfadimethoxine used for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to sulfadimethoxine: respiratory tract and ENT organs (angina, bronchitis, pneumonia, otitis media, sinusitis), biliary and urinary tracts, meningitis, shigellosis, wound infection, pyoderma, gonorrhea, trachoma , erysipelas, toxoplasmosis; resistant forms of malaria (in combination with antimalarial drugs).Directions for use
Sulfadimethoxine prescribed orally after meals, 1 time per day with an interval of 24 hours between doses.Adults are prescribed:
- for mild infections - on the first day, 1 g (2 tablets), on subsequent days - by
0.5 g (1 tablet);
- for moderate and severe infections - on the first day, 2 g (4 tablets), on subsequent days - 1 g (2 tablets). If necessary, the dose can be increased.
Children under 12 years of age are prescribed: on the first day, 25 mg/kg, on subsequent days - 12.5 mg/kg; children over 12 years old - 1 g (2 tablets) on the 1st day, 0.5 g on subsequent days
(1 tablet).
The duration of treatment depends on the severity of the disease and is 7-10 days.
Treatment must be continued for 2-3 days after body temperature normalizes.
Side effects
From the nervous system: headache.From the digestive system: dyspepsia, nausea, vomiting, cholestatic hepatitis.
Allergic reactions: skin rash, drug fever.
From the hematopoietic system: rarely - leukopenia, agranulocytosis.
Contraindications
Contraindications to the use of the drug Sulfadimethoxine are: hypersensitivity to sulfonamides and other components of the drug, inhibition of bone marrow hematopoiesis, renal and/or liver failure, congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azotemia, pregnancy, lactation, children under 2 months of age.Pregnancy
During treatment with the drug Sulfadimethoxine Breastfeeding should be discontinued, since the drug passes into breast milk and can cause kernicterus in children, as well as hemolytic anemia in children with glucose-6-phosphate dehydrogenase deficiency.Interaction with other drugs
Sulfadimethoxine reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins). Antibacterial activity is reduced by procaine, benzocaine and tetracaine, and enhanced by barbiturates and para-aminosalicylic acid. Methotrexate and phenytoin increase the toxicity of sulfadimethoxine; non-steroidal anti-inflammatory drugs, thioacetazone, chloramphenicol, myelotoxic drugs increase the toxic effect on the blood. Sulfadimethoxine enhances the effect of indirect anticoagulants, phenytoin, sulfonamides with hypoglycemic action; reduces the effectiveness of oral contraceptives. Pyrazolone derivatives, indomethacin and salicylates increase the free fraction of sulfadimethoxine in the blood.Overdose
:Possible worsening side effects.
Treatment is symptomatic.
Storage conditions
Store in a place protected from light at temperatures from 8°C to 25°C. Keep out of the reach of children.Shelf life - 5 years.
Release form
Sulfadimethoxine - tablets.10 tablets in a blister pack and in a pack; 10 tablets in a blister pack.
Compound:
1 tablet Sulfadimethoxine contains sulfadimethoxine 0.5 g.
Excipients: sodium starch glycolate, pregelatinized starch, calcium stearate.
Additionally
Use of the drug Sulfadimethoxine in children under 2 months of age, it is possible only for the treatment of congenital toxoplasmosis for health reasons.The limitation to the medical use of the drug is chronic heart failure.
Prescribing the drug to patients over 65 years of age should be avoided due to the increased risk of severe side effects.
During a course of treatment, it is necessary to systematically monitor the state of renal function and peripheral blood patterns.
During therapy, large amounts of alkaline drinking are recommended, sufficient to maintain diuresis at a level of at least 1.2 l/day for adults.
During treatment with the drug, you must follow the dosage regimen, take the prescribed dose every 24 hours, and do not skip doses. If you miss a dose, take it as soon as possible; do not take if it is almost time for the next dose; do not double the dose. It is recommended to avoid exposure to direct sunlight and ultraviolet radiation.
There are no data on the effect of the drug on the ability to drive vehicles and perform potentially hazardous activities.
Basic parameters
| Name: | SULPHADIMETOXINE |
| ATX code: | J01ED01 - |
Composition per tablet:
active substance: sulfadimethoxine -500 mg;
excipients: microcrystalline cellulose - 42.0 mg, crospovidone - 26.5 mg, povidone (medium molecular weight polyvinylpyrrolidone, povidone K-25) - 25.5 mg. calcium stearate - 6.0 mg.
Description: Round flat-cylindrical tablets of white or off-white color with a chamfer and a score. Pharmacotherapeutic group:Antimicrobial agent, sulfonamide. ATX:J.01.E.D Long-acting sulfonamides
Pharmacodynamics:Antimicrobial bacteriostatic agent. The mechanism of action is due to competitive antagonism with para-aminobenzoic acid, inhibition of dihydropteroate synthetase, disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines. Active against gram-positive and gram-negative microorganisms: Staphylococcus spp., Streptococcus spp., incl. Streptococcus pneumoniae, Friedlander's bacilli, Escherichia coli, Shigella spp., Chlamydia trachomatis.
Sulfadimethoxine has no effect on strains of bacteria resistant to sulfonamides.
Pharmacokinetics:When taken orally, it is absorbed relatively slowly and is detected in the blood after 30 minutes. With a single dose (at a dose of 1-2 g), the time to reach maximum concentration in the blood (Tmax) is 8-12 hours.
Therapeutic concentration in adults is achieved by taking 1-2 g on 1 day and 0.5-1 g on subsequent days. Communication with blood proteins - 90-99%.
The drug accumulates in the blood, primarily due to a high degree of binding to blood proteins (90-99%). Well distributed throughout organs and systems. But unlike other representatives of long-acting sulfonamides, it poorly penetrates the blood-brain barrier (BBB) and its concentration in the cerebrospinal fluid is low. However, with inflammation of the meningeal membranes, the permeability of the BBB increases sharply. It penetrates well into the pleural fluid (60-90% of the concentration in the blood), into the biliary system, where its concentration is 1.5-4 times higher than in the blood.
Preferential metabolism occurs via the microsomal glucuronidation pathway associated with cytochrome P450 and NADPH-dependent.
Strong binding to plasma proteins and high reabsorption in the renal tubules (93-97.5%) contribute to the slow elimination of the drug from the body. The blood contains 5-15% of acetylated metabolites, the urine contains 10-25% acetyl derivatives and 75-90% sulfadimethoxine glucuronide; the latter is highly soluble and does not provoke the development of crystalluria. The acetyl derivative is not reabsorbed and is completely excreted by the kidneys. After 24 hours, 20-40% of the dose taken is excreted, after 48 hours - up to 56%, after 96 hours - up to 83.3%.
Indications: Diseases caused by sensitive microflora: sore throat, otitis media, sinusitis; bronchitis, pneumonia; dysentery; pyoderma; erysipelas; trachoma; wound infections; gonorrhea; diseases of the urinary and biliary tract; malaria (as part of complex therapy). Contraindications:Hypersensitivity to sulfadimethoxine or other components of the drug; inhibition of bone marrow hematopoiesis; renal/liver failure, chronic heart failure, congenital deficiency of glucose-6-phosphate dehydrogenase; porphyria; azotemia;
pregnancy and breastfeeding, children under 12 years of age (for this dosage form and dosage).
Pregnancy and lactation:The use of the drug during pregnancy and breastfeeding is contraindicated. If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.
Directions for use and dosage:Inside, 1 time per day. Adults, on the 1st day - 1-2 g, then - 0.5-1 g / day.
For children from 12 to 18 years of age: the initial and maintenance doses are 1 g and 0.5 g, respectively.
is 7-14 days.
Side effects:Allergic reactions; headache, dyspepsia, leukopenia, agranulocytosis, cholestatic hepatitis. Interaction:The effect of sulfadimethoxine is enhanced when taken in combination with diaminopyrimidine derivatives (trimethoprim, tetroxoprim,).
Reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins). increases the risk of developing toxic reactions.
Methotrexate and other folate antagonists increase the risk of developing folate deficiency.
Procaine and tetracaine reduce antibacterial activity. PAS and barbiturates enhance the antimicrobial effect. Salicylates increase the activity and toxicity of sulfadimethoxine. promotes the development of photosensitivity. Non-hormonal anti-inflammatory drugs increase the toxic effect on the blood (leukopenia, agranulocytosis).
Strengthens the effect of indirect anticoagulants, phenytoin, sulfonamides with hypoglycemic action;
Reduces the effectiveness of oral contraceptives. Enhances the metabolism of cyclosporine.
Special instructions:During therapy, it is recommended to drink plenty of fluids and regularly monitor blood and urine parameters. Impact on the ability to drive vehicles. Wed and fur.:During the treatment period, care should be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.Latin name: Sulfadimethoxinum
ATX code: J01ED01
Active ingredient: Sulfadimethoxine
Manufacturer: Darnitsa CJSC, Ukraine
Conditions for dispensing from a pharmacy: Over the counter
Composition of the drug
One tablet contains five hundred milligrams of sulfadimethoxine, calculated as one hundred percent dry matter. As additives to the active ingredient, the composition contains aerosil, gelatin, calcium stearate, and potato starch.
Medicinal properties
Sulfadimethoxine is an antibacterial drug with a pronounced long-term effect. This antibiotic has proven its effectiveness against both gram-negative and gram-positive microorganisms, such as staphylococci, klebsiella, streptococci, salmonella, toxoplasma, shigella, malarial plasmodia, some chlamydia, including Chlamydophila trachomatis, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae. Absorption of the active substance by the gastrointestinal tract occurs relatively slowly. The substance can be detected in the blood after thirty minutes. The maximum concentration is reached after eight to twelve hours. The therapeutic concentration required for an adult occurs when taking one or two grams of the substance on the first day, and half a gram or one gram on the following days. Bioavailability ranges from seventy to one hundred percent. The half-life of the antibiotic is forty hours. Excretion from the body is carried out mainly by the kidneys, partly with bile.
Indications for use
Sulfadimethoxine helps with uncomplicated inflammatory diseases of the biliary and urinary tract, dysentery. It is also used for trachoma, erysipelas, wound infection, otitis (read more about purulent otitis in the article:), tonsillitis and sinusitis, bronchitis, pyoderma, gonorrhea, pneumonia, toxoplasmosis, malaria, cholecystitis, beshikha.
Release forms
Average price - 40 rubles
Sulfadimethoxine is a white or yellowish-cream tablet, odorless, round in shape, with a flat surface and a line on one side.
Directions for use
Sulfadimethoxine is taken every day, on the first day a dosage of one to two grams is usually prescribed, and on the following days from half a gram to one gram.
For children, this antibiotic is prescribed twenty-five milligrams on the first day and twelve and a half milligrams on the next.
The duration of treatment is as long as prescribed by the attending physician, but usually the course of treatment with antibiotics lasts no more than ten days and is accompanied by the use of probiotics to restore the intestinal microflora.
During pregnancy and breastfeeding
Sulfadimethoxine crosses the placental barrier and is excreted into breast milk. For this reason, the antibiotic is not prescribed to pregnant and breastfeeding women.
Contraindications
The main contraindication to the use of Sulfadimethoxine is hypersensitivity to the components. You should not take the drug if you have severe dermatitis, hepatitis, drug fever, porphyria, or if you are breastfeeding or pregnant.
Precautions
The medicine is prescribed with particular caution to those categories of patients who have impaired liver and kidney function, as well as to patients with chronic heart failure and diseases of the circulatory system.
Interaction with other drugs
The drug tends to reduce the effectiveness of bactericidal antibiotics that act exclusively on dividing microorganisms, such as cephalosporins and penicillins.
When sulfadimethoxine is combined with barbiturates, its activity increases, and with salicylates, the toxic effect of the drug increases, as well as when combined with methotrexate and diphenine. And when combined with streptomycin, monomycin, kanamycin, the antibacterial effect will not change. When sulfadimethoxine is combined with nalidixic acid, chloramphenicol, or nitrofurans, a decrease in the overall therapeutic effect may be observed.
Side effects
Side effects include allergies such as urticaria, bronchospasms, hyperemia, swelling of the tongue and upper lip, Quincke tumor, Lyell's and Stephen-Jones syndromes. As well as photodermatosis, anaphylactic shock and others. Nausea and vomiting, cholestatic hepatitis, dyspepsia, agranulocytosis, fever, headache and leukopenia, pancreatitis, dry mouth, diarrhea, jaundice, hepatic encephalopathy, syncope, aseptic meningitis, increased intracranial pressure, depression, optic neuropathy, psychosis, insomnia are common. , myocarditis, fibrosing alveolitis, periarteritis nodosa, dark yellow urine staining, tubular necrosis, hypothyroidism, hypoglycemia, thrombocytopenia, hemolytic anemia, hypothrombanemia.
Overdose
There is no information about cases of overdose.
Conditions and shelf life
The drug must be stored away from light sources, in a dark place. It is also recommended to hide the tablets out of the reach of children. The medicine can be stored for up to 5 years. It is not recommended to use the drug after this period has expired. The date of manufacture must be looked at on the packaging of the drug. If the storage conditions are not met, there is no effectiveness from taking it.
Analogues
NizhPharm, Russia
Price— 79 rubles
The composition includes: Dioxomethyltetrahydropyrimidine + Sulfadimethoxine + Trimecaine + Chloramphenicol, ointment in an aluminum tube.
Pros:
- The possibility of topical application of the antibiotic directly to damaged necrotic tissue with minimal negative effects on the liver and intestines due to less absorption into the blood.
- Higher effectiveness for skin lesions when using a topical agent in the form of an ointment than in the form of tablets.
- You do not need a doctor's prescription to purchase this medicine.
Cons:
- Cons: For external use only.
- Due to the decrease in the effectiveness of the antibiotic after long-term use, it is not recommended to use it for more than the number of days prescribed by the therapist.
Antibacterial drugs are used in most cases of diseases caused by microorganisms. Increasingly, attending physicians prescribe Sulfadimethoxine. Many specialists and patients are confident in its effectiveness. What do you need to know about the drug "Sulfadimethoxine"? Price of the drug, indications for its use, possible side effects. Some are interested in the presence of analogues. Others are interested in something else about the drug "Sulfadimethoxine": is it an antibiotic or not? All these details will be discussed below.
Release form
There is only one dosage form in which Sulfadimethoxine is produced. Reviews show that customers especially appreciate that it is incredibly easy to use. The drug comes in the form of tablets (yellowish-cream or white). The product in question does not have a pronounced characteristic odor. The shape of the tablets is round.
Medicinal properties
Is Sulfadimethoxin an antibiotic or not? The instructions say yes. The drug in question belongs to the group of antibacterial agents with long-term, pronounced action. Many people prefer the antibiotic Sulfadimethoxine to all other drugs in this group. Reviews confirm that it consistently proves its effectiveness against a variety of microorganisms, both gram-positive and gram-negative. These include Shigella, Staphylococcus, Salmonella, Klebsiella, Streptococcus, Toxoplasma, and some types of Chlamydia.
Absorption of the active substance in the gastrointestinal tract occurs over a relatively long period of time. But the medicine enters the bloodstream after half an hour. And its maximum concentration is achieved only after eight to twelve hours. Adults are recommended to maintain a blood concentration of the drug in an amount of one to two grams after the first day of treatment and in an amount of half a gram to one gram during the subsequent treatment period. The bioavailability of the substance in question ranges from seventy to one hundred percent. While the half-life of this drug is at least forty hours. The substance is partly excreted from the patient’s body through the kidneys, and partly along with bile. This is exactly the effect of “Sulfadimethoxine”.
Indications for use
It is important to understand how to use the medicine correctly. What should you know about the drug "Sulfadimethoxine" in this regard? Reviews report that when it comes to indications for use, it is important to carefully follow the instructions. Thus, it is appropriate to use the drug in question only in the following cases: for dysentery, inflammation of the biliary tract, trachoma, inflammation of the urinary tract, otitis, erysipelas, wound infection, pyoderma, tonsillitis, gonorrhea, sinusitis, beshikha, malaria, pneumonia, toxoplasmosis, cholecystitis.
How much will you have to spend on Sulfadimethoxine? The price of the drug in question is more than affordable. So, for tablets of two hundred milligrams you will need to pay up to forty rubles, for tablets of five hundred milligrams - up to fifty-five rubles.
How to take Sulfadimethoxine?
This medicine is used daily (one or two grams on the first day and from half a gram to one gram earlier). The dose for a child is a quarter of the adult dosage. The duration of therapy should be adjusted by a specialist. It is necessary to simultaneously take probiotics, which will help restore the patient’s natural intestinal microflora.
Contraindications to the use of the drug in question are:
- pregnancy;
- breastfeeding period;
- individual sensitivity to individual components of the drug;
- hepatitis;
- porphyria;
- severe dermatitis;
- drug fever;
- serious impairment of kidney or liver function.
No cases of overdose were recorded. However, you should not voluntarily change the amount of medication prescribed by your doctor.
"Sulfadimethoxine": analogues
Among the drugs that could replace the drug in question are the following:
- "Bactrim".
- "Aregdin."
- "Bactrim forte"
- "Dapson Fatol".
- "Argosulfan".
- "Groseptol".
- "Berlocid".
- "Duo Septol".
- "Sulgin".
- "Biseptol".
- "Phtalazol".
- "Brifeseptol".
- "Inhalipt."
- "Lidaprim."
- "Trimezol".
- "Etazol".
- "Dermazin".
- "Cotripharm".
- "Septrin."
- "Dvaseptol".
- "Streptocide".
- "Sinersul."
- "Streptocide soluble."
- "Ziplin."
- "Streptonitol."
- "Oriprim."
- "Co-trimoxazole."
- "Sumetrolim".
- "Polseptol."
- "Sulgin".
- "Methosulfabol".
- "Sulfalene".
- "Albucid".
- "Sulotrim".
- "Phthalylsulfathiazole."
- "Sulfadimezin".
- "Sulfargin".
- "Sulfasalazine."
- "Sulfamethoxazole".
- "Sulfanilamide".
- "Sulfacetamide".
Let's take a closer look at two other popular analogues. One of them is "Arghedin". It is usually used to combat bedsores, ulcers, and infectious skin lesions. Indications for its use are also the following conditions:
- deep contamination of wounds;
- skin grafting;
- infected burns;
- superficial wounds with weak exudation.
Use this medicine once or twice a day. In especially acute cases, it is recommended to use the drug four times a day.
The duration of the course must be adjusted by the attending physician, but cannot exceed two months.
Another analogue is Levosin. Its main components are sulfadimethoxine, dioxomethyltetrahydropyrimidine, chloramphenicol and trimecaine. The product is an ointment in an aluminum tube.
What are its advantages? Higher efficiency than using tablets. Dispensed from pharmacies without a prescription. Apply topically, directly to affected skin areas.
However, there are also some disadvantages. For example, a medicine is intended exclusively for external use. As you use it, the effectiveness of the drug decreases.
These drugs can effectively replace Sulfadimethoxine? Analogues of this medication are actively used by specialists. They are worth giving them some attention.
Side effects
What adverse reactions are possible when using the drug "Sulfadimethoxine"? Reviews warn of the possibility of some unpleasant manifestations. Side effects include swelling of the tongue, urticaria, hyperemia, bronchospasm, swelling of the upper lip, Stephen-Jones syndrome, nausea, Quincke's edema, photodermatosis, Lyell's syndrome, anaphylactic shock, vomiting, diarrhea, psychosis, myocarditis, cholestatic hepatitis, fever, anaphylactic shock , thrombocytopenia, hypothrombanemia, dark yellow urine, dyspepsia, pancreatitis, jaundice, optic neuropathy, hypothyroidism, agranulocytosis, dry mouth, tubular necrosis, insomnia, syncope, hemolytic anemia, fever, aseptic meningitis, hypoglycemia, headache, depression, leukopenia, hepatic encephalopathy, fibrosing alveolitis, diarrhea, and increased intracranial pressure.
Interaction with other drugs
The patient should be carefully studied before starting to take the application. Tablets significantly reduce the effectiveness of some other bactericidal antibiotics. We are talking only about those drugs whose effect extends exclusively to dividing microorganisms (for example, penicillins and cephalosporins).
In cases where the drug is taken simultaneously with any barbiturate drugs, this kind of combination significantly increases its activity, while at the same time the combination with salicylates provokes an increase in the toxic properties of the substance. The same effect is caused by the interaction of the drug in question with diphenin and methotrexate. No adjustments to the treatment regimen will be required when using monomycin, streptomycin and kanamycin in parallel.
It is prohibited to use the drug in question simultaneously with substances such as methenamine, diphenin, antidiabetic drugs, neodicoumarin and other anticoagulants.
Conditions and shelf life
In order for the drug in question not to lose its beneficial properties, it is important to store it in suitable conditions that would not allow it to deteriorate. The medicine should be kept in a place where children do not have access. The product in question can be stored for no more than five years. After this, it is not recommended to take it. It may even be somewhat dangerous for the patient. Therefore, when purchasing, pay attention to the date of manufacture of the drug, which can be found on the packaging. Following this simple rule will help make treatment more effective.
It is important to comply with the conditions of use prescribed for the drug. Tablets must be used exclusively in the manner recommended by the attending physician. In this case, the therapy will be most effective.
“Sulfadimethoxine” is used for infectious and inflammatory diseases caused by microorganisms sensitive to it. It is prescribed for the treatment of tonsillitis, otitis media, dysentery, erysipelas, trachoma, and sinusitis. The medicine is used in inflammatory diseases of the urinary and biliary tract, wound infections. Other indications for the use of “Sulfadimethoxine” are: purulent infections, sepsis, infectious intestinal diseases (enterocolitis, dysentery, etc.), purulent diseases of the biliary tract.
It is also used for infectious eczema, genitourinary tract infections (gonorrhea, etc.), skin diseases (furunculosis, erysipelas, pyoderma, inflammation of the sebaceous glands), inflammatory lesions of the central nervous system, trachoma, malaria (in combination with antimalarials). Analogues of “Sulfadimethoxine” are: “Sulfalene”, “Sulfapyridazine”, “Sulfalene-meglumine”.
How to use Sulfadimethoxine
Adults should take 1 g of “Sulfadimethoxine” on the first day of therapy; children are given the drug at the rate of 25 mg per 1 kg of weight. Over the next days, these doses are reduced by 2 times. The medicine is taken once a day. In severe forms of the disease, Erythromycin, Penicillin and some others are prescribed simultaneously with Sulfadimethoxine. The product is effective with a treatment duration of 7 to 10 days. After the body temperature returns to normal, maintenance doses of the drug are taken for another three days.
For infectious eczema, furunculosis, inflammation of the sebaceous glands, take 0.5-1.0 g per day. The course of treatment ranges from 7 to 30 days. To treat trachoma, take 1-2 g of Sulfadimethoxine orally on the first day, and then drink 0.5 g once a day for 10 days. At the same time, a 10% solution of the drug is instilled into the affected eye, 2-3 drops 3-4 times a day.
It should be taken into account that with simultaneous use, Sulfadimethoxine reduces the therapeutic effect of bactericidal antibiotics. The antimicrobial effect of Sulfadimethoxine is reduced by: para-aminosalicylic acid, barbiturates, Procaine, Benzocaine, Tetracaine. Regular blood tests are necessary during therapy.
Contraindications, side effects of Sulfadimethoxine
“Sulfadimethoxine” is contraindicated in case of porphyria, inhibition of bone marrow hematopoiesis, chronic heart failure, liver and kidney failure, azotemia, during pregnancy and lactation, deficiency of glucose-6-phosphate dehydrogenase, hypersensitivity to the components of the drug. The drug may cause unwanted side effects: headache, cholestatic hepatitis, abdominal discomfort, diarrhea, constipation, vomiting, nausea, drug fever, skin rashes, leukopenia, agranulocytosis.
