Glutamic acid - instructions, use, reviews. Glutamic acid - official* instructions for use

Glutamine is one of the amino acids that make up the proteins in our body. Our bodies synthesize it on their own, and it is also found in many foods in sufficient quantities. Its effect on the body is very diverse. It helps transmit signals to the brain through the nerves, and gamma-aminobutyric acid is formed from it, which improves blood supply to the brain. A derivative of glutamic acid (monosodium glutamate) is used as a flavoring additive - it gives food a pleasant taste. The amino acid also neutralizes ammonia, a toxic substance formed during the breakdown of proteins. It turns into urea and is excreted from the body in urine. Glutamine also helps the body more easily endure psychological and physical stress, eliminates allergies and inflammation. This substance is very important for the functioning of the immune system.

Applications of Glutamic Acid

Glutamic acid has found wide application in medicine. It is produced in the form of tablets, powder and granules for the preparation of a suspension and is used as a detoxification and nootropic agent that stimulates metabolism in the central nervous system. The amino acid is also involved in protein and nitrogen metabolism and redox processes in the brain. It is prescribed in combination with other drugs for epilepsy, psychosis, schizophrenia, insomnia, depression, myopathy, consequences of meningitis, encephalitis, intracranial birth injury, Down's disease, cerebral palsy. The tablets should be taken 15-30 minutes before meals, twice or thrice a day, 1 gram for adults, 0.5 g for children 7-9 years old, 0.4 g for children 5-6 years old, 0.15- 0.25 g – children 1-4 years old. The course of treatment should last at least 1-2 months.

Glutamic acid in bodybuilding

Glutamic acid is necessary for every person and will be useful for representatives of any sport. High levels of glutamine in muscles increase performance and endurance and reduce the time it takes for muscles to recover after exercise. When using glutamic acid, the body needs to spend less energy on the synthesis of amino acids. The nitrogen content in the body and the production of growth hormones also increase. With sufficient nitrogen levels, the aging process slows down. With a normal level of glutamine in the body, potassium ions more easily penetrate muscle cells, which contributes to their better contraction and increased functionality. Often, the amino acid is combined with cystine and glycine to improve heart function, increase muscle endurance and normalize redox processes in the body.

Glutamic acid belongs to the group of non-essential amino acids and plays an important role in the body. Its content in the body is up to 25% of all amino acids.

On an industrial scale, glutamic acid is obtained by microbiological synthesis. In its chemically pure form, it has the appearance of white or colorless, odorless crystals with a sour taste; crystals do not dissolve well in water. For better solubility, glutamic acid is converted into a sodium salt - glutamate.

Uses of glutamic acid

In the food industry, glutamic acid is known as a food additive called E620. It is used as a flavor enhancer in a number of products along with salts of glutamic acid - glutamates.

Glutamic acid is added to semi-finished products, various instant products, culinary products, and broth concentrates. It gives food a pleasant meaty taste.

In medicine, the use of glutamic acid has a slight psychostimulating, stimulating and nootropic effect, which is used in the treatment of a number of diseases of the nervous system.

The importance of glutamic acid for the body

The role of glutamic acid is difficult to overestimate; it:

Participates in the synthesis of histamine, serotonin and a number of other biologically active substances;
Neutralizes a harmful decomposition product - ammonia;
Is a mediator;
Included in the cycle of transformations of carbohydrates and nucleic acids;
Folic acid is synthesized from it;
Participates in energy exchange with the formation of AFT in the brain.

In the body, glutamic acid is part of proteins; it is present in the blood plasma in free form, and also as a component of a number of low-molecular substances. The human body contains a reserve of glutamic acid; in case of its deficiency, it first goes to where it is needed most.

Glutamic acid plays an important role in the transmission of nerve impulses. Its binding to certain receptors of nerve cells leads to the excitation of neurons and acceleration of impulse transmission. Thus, glutamic acid performs neurotransmitter functions.

With an excess of this amino acid in the synapse, overexcitation of nerve cells and even their damage can occur, which leads to diseases of the nervous system. In this case, the protective function is taken over by glial cells, which surround and protect the neurons. Neuroglial cells absorb and detoxify excess glutamic acid in the brain and peripheral nerves.

The amino acid glutamine increases the sensitivity of muscle fibers to potassium by increasing the permeability of cell membranes to it. This trace element plays an important role in muscle contraction, increasing the force of muscle contraction.

Glutamic acid in sports

Glutamic acid is a fairly common component of sports nutrition. This is a non-essential amino acid for the human body, and the transformation of other amino acids occurs precisely through the glutamine amino acid, which plays an integrating role in the metabolism of nitrogenous substances. If the body lacks an amino acid, it is possible to compensate for its content by converting from those amino acids that are found in excess.

If the physical load on the body is very high, and the intake of protein from food is limited or does not meet the body’s needs, the phenomenon of nitrogen redistribution occurs. In this case, the proteins included in the structure of the internal organs go to build the fibers of skeletal and cardiac muscles. Therefore, glutamic acid plays an irreplaceable role in sports, because it is an intermediate step in the transformation of those amino acids that the body lacks.

The conversion of glutamic acid into glutamine in order to neutralize ammonia is one of its main functions. Ammonia is very toxic, but it is an unchanged product of metabolism - it accounts for up to 80% of all nitrogenous compounds. The greater the load on the body, the more toxic nitrogen decomposition products are formed. In sports, glutamic acid takes on the role of reducing ammonia levels by binding it into non-toxic glutamine. In addition, according to reviews, glutamic acid quickly restores the condition of athletes after competitions, as it binds excess lactate, which is responsible for the feeling of muscle pain.

In athletes, when there is a lack of glucose levels during intense physical activity, glutamic acid is converted into an energy source - glucose.

According to reviews, glutamic acid is well tolerated, has no side effects and is completely harmless to the body. Studies have shown that 100 g of protein food contains 25 g of glutamic acid. This amino acid is a natural component of animal foods, and negative reviews about glutamic acid are somewhat exaggerated.

Glutamic acid is a nootropic and detoxifying agent that affects protein metabolism, as well as brain metabolism. Available in the form of granules for the preparation of a solution for internal use and enteric-coated tablets.

Pharmacological action of Glutamic acid

Glutamic acid is a drug from a group of non-essential amino acids. It can be synthesized by the human body. Its synthesis takes place in the kidneys, liver, lungs and brain. In order for the glutamine molecule to be formulated, two other amino acids must be present: isoleucine and valine.

This drug takes an active part in the regulation of metabolic processes in the central nervous system and helps bind ammonia. Glutamic acid is also an amino acid that plays the role of a neurotransmitter that has high metabolic activity in the brain. It stimulates all redox processes and the metabolism of brain proteins, normalizes the metabolic process by changing the functional state of the endocrine and nervous systems.

The use of Glutamic acid affects the strength of the excitation process in the synapses of the central nervous system and removes excess ammonia. The active components of the drug are contained in myofibrils and take part in the synthesis of acetylcholine, other amino acids, adenosine triphosphate and urea. Taking the drug promotes the transfer and maintenance of calcium in the brain in the required concentration, stimulates the normalization of the redox potential. Glutamic acid increases the body's resistance to hypoxia, connects the metabolism of carbohydrates and nucleic acids, and normalizes the content of glycolysis in tissues and blood.

According to the instructions, Glutamic acid has a hepatoprotective effect on the body, inhibiting the ability of the stomach to secrete secretions.

Indications for use of Glutamic acid

The drug is recommended for use as part of complex therapy for epilepsy (presence of small seizures with equivalents), psychoses (somatogenic, involutional, intoxication), schizophrenia, mental exhaustion, reactive depressive state, consequences of encephalitis and meningitis, insomnia, progressive myopathy and depression.

The instructions for Glutamic acid also indicate that the drug is useful in diagnosing mental development delays of various etiologies, cerebral palsy, the consequences of intracranial birth injuries, polio in any period, and Down's disease.

The drug is indicated for use in the presence of symptoms of toxic neuropathy when taking isonicotinic acid hydrazines.

Directions for use and dosage

Glutamic acid is taken orally 1 g two to three times a day.

The dosage of the medicine for children depends on age:

Up to 1 year – 100 mg;
From 1 to 3 years – 150 mg;
3-4 years – 250 mg;
5-6 years – 400 mg;
7-9 years – 750 mg;
Over 10 years – 1 year.

For diagnosed oligophrenia – 150-200 mg. The course of treatment is from one to twelve months.

Glutamic acid should be taken 30 minutes before meals. When symptoms of dyspepsia develop - after or during meals.

Side effects of glutamic acid

In reviews of Glutamic acid, there are reports that during or after taking the drug, allergic reactions, vomiting, nausea, diarrhea, intestinal pain, and increased excitability may occur. With long-term use of the medicine, anemia, irritation of the oral mucosa, leukopenia, cracks in the lips, and a drop in hemoglobin levels in the body are possible.

Contraindications to the use of Glutamic acid

Therapy with the drug is prohibited in the presence of such indicators as febrile syndrome, peptic ulcer of the duodenum and stomach, renal and liver failure, leukopenia, anemia, various psychotic reactions, depressed bone marrow hematopoiesis, obesity, nephrotic syndrome.

Overdose

Among the reviews of Glutamic acid there is no information about an overdose of the drug.

Conditions and shelf life

The medication should be stored in a dry, cool, dark place, out of reach of children, at an optimal temperature of no more than 25⁰C. The shelf life of Glutamic acid is 4 years from the date of release.

During therapy, it is necessary to conduct regular general clinical blood and urine tests.

Glutamic acid can also be used to reduce neurotoxic effects after taking other drugs.

Hello, dear readers of the wonderful site Review about and my review itself. So I decided to share with you my experience of using one drug that is not widely known, which is available in tablets - Glutamic acid. Nowadays, it is sold in pharmacies, and is absolutely accessible to everyone, and it is cheap.

Personal experience

I became acquainted with Glutamic acid two years ago, as I was involved in sports and body lifting for a very long period of time. I found them quite quickly, in one of the pharmacies in our city, and they are produced in Ukraine, the Kiev Vitamin Plant. I worked out for quite a long time, I was very tired, I didn’t have enough strength to support my family, and then I decided to take them to improve recovery after training. When I bought them, I saw that they come in blisters, they contain 10 tablets, and the color is light blue. And so I started taking them two at a time, washing them down with water. Due to the fact that their surface is smooth, they are very easy to swallow. This means I took it before meals and twice a day. Yes, indeed, after training, I was very tired before taking this medicine, but somewhere in the second week, after using it, I felt that I was going home with ease, I didn’t fall on the sofa at home, but I did absolutely all the housework. My husband and children were surprised at me, because before I paid practically no attention to them, but lived with the goal of having a beautiful body, and my husband likes it. Since then, I have been taking these miracle pills, but at intervals of several months, and I live an absolutely full life, and I practically do not get sick, thanks to the function of the drug, which also perfectly strengthens the immune system to everything. Glutamic acid is completely harmless, so it can be consumed by almost all healthy people who have indications for it.

Literally three months ago, I read that these tablets can be used to make a face mask, which has an excellent effect on it, having a moisturizing, rejuvenating effect, regenerates skin areas, and also has an anti-inflammatory effect and wound-healing properties. Yesterday I made it for the first time, next time I will make a mask next week.

I make the mask like this: I take 5 tablets and crush them using a wooden masher, pour a dessert spoon of water into it, check the consistency to make sure it’s a paste, drip a few drops of aloe juice from my flowerpot and apply it to my face. I wash it off after 15 minutes.

The main substance glutamic acid, plus additional additives, has a neotropic pharmacological effect.

used for cerebral palsy, inhibition of mental development of various etiologies, after intracranial birth trauma, Down's disease, and polio;

the drug is prescribed in medicine for signs of schizophrenia, as well as epilepsy, but only in the initial and weak stages;

for psychoses, depressive states, insomnia, encephalitis and meningitis - with their consequences;

with mental exhaustion, myopathy, in the progression stage;

used for neuropathy of toxic origin that arose after use, or during its use of isonicotinic acid derivatives;

Contraindications for use:

if there is increased excitability, the drug should not be taken;

contraindicated in febrile conditions;

in case of violent mental reactions, it should not be taken;

with suppression of hematopoiesis in the bone marrow;

in case of problems with the kidneys and liver;

with peptic ulcer;

Contraindications include anemia;

obesity;

with nephrotic syndrome;

with hypersensitivity to this component;

More detailed information about the drug can be found in the instructions for use. I have no right to advise this drug, since it has both contraindications and side effects, and I just shared my experience of using it.

Video review

All(5)

active ingredient: 1 tablet contains L-glutamic acid 250 mg;

excipients: microcrystalline cellulose, povidone, calcium stearate;

shell: film coating mixture Opadry II Blue: hypromellose, lactose monohydrate, polyethylene glycol, titanium dioxide (E 171), indigo carmine (E 132), quinoline yellow (E 104).

Dosage form. Film-coated tablets.

Basic physical and chemical properties: round tablets with a biconvex surface, blue film-coated.

Pharmacotherapeutic group. Drugs acting on the nervous system.

ATX code N07X X.

Pharmacological properties

Pharmacodynamics.

A non-essential amino acid that participates in the processes of transamination of amino acids in the body, in protein and carbohydrate metabolism, stimulates oxidative processes, promotes the neutralization and removal of ammonia from the body, and increases the body's resistance to hypoxia. Promotes the synthesis of acetylcholine and ATP, the transport of potassium ions, and plays an important role in the activity of skeletal muscles. Glutamic acid belongs to the neurotransmitter amino acids that stimulate the transmission of excitation at the synapses of the central nervous system.

Pharmacokinetics.

Glutamic acid is well absorbed when taken orally. It is quickly eliminated from the blood, accumulating mainly in muscle and nervous tissues, in the liver and kidneys, and penetrates the blood-brain barrier and cell membranes. During absorption, glutamic acid is partially transaminated to form alanine. Under the influence of the enzyme glutamate decarboxylase, it is converted in the brain into a mediator - gamma-aminobutyric acid.

About 4-7% of it is excreted unchanged in the urine, the rest is utilized in the process of metabolic transformations.

Clinical characteristics.

Indications

Treatment of epilepsy, mainly minor seizures with equivalents, somatogenic, involutional, intoxication psychoses, reactive states with symptoms of depression, exhaustion; with mental retardation in children, Down's disease, with cerebral palsy, poliomyelitis (acute and recovery periods), with progressive myopathy, to eliminate and prevent neurotoxic phenomena that may occur when using isoniazid and other drugs of the isonicotinic acid hydrazide group.

Contraindications

Feverish conditions, increased excitability, pronounced psychotic reactions, liver and/or kidney failure, nephrotic syndrome, gastric and duodenal ulcers, diseases of the hematopoietic organs, anemia, leukopenia.

Interaction with other drugs and other types of interactions.

Together with thiamine and pyridoxine (preparations of B vitamins), glutamic acid can be used for the prevention and treatment of neurotoxic phenomena caused by the patient's use of drugs of the GINK group (isonicotinic acid hydrazide, for example, ftivazide, isoniazid).

For myopathy and muscular dystrophy, Glutamic acid is effective in combination with pachycarpine or glycol.

Features of application

During treatment, it is necessary to systematically conduct urine and blood tests. If side effects occur, it is recommended to reduce the dose of the drug.

Glutamic acid can also be used to relieve neurotoxic effects associated with taking other drugs.

After taking Glutamic acid, you should rinse your mouth with a weak solution of sodium bicarbonate.

The drug contains lactose, so it should not be prescribed to patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

Use during pregnancy or breastfeeding.

This medicine should not be used during pregnancy or breastfeeding.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

Considering the possible effect of the drug on the nervous system, the drug should be used with caution when driving vehicles or operating other mechanisms.

Directions for use and doses

For adults, take a single dose of 1 g 2-3 times a day.

For children, single doses are: 3-6 years – 250 mg, 7-9 years – 0.5-1 g; from 10 years – 1 year

The frequency of administration is 2-3 times a day.

For oligophrenia - 100-200 mg per 1 kg of the patient’s body weight for several months.

Take 15-30 minutes before meals, if dyspeptic symptoms develop - during or after meals.

The course of treatment is from 1-2 to 6-12 months.

Children.

The medicine should not be used in children under 3 years of age.

Overdose

Possible increased manifestations of adverse reactions.

Treatment: symptomatic therapy, gastric lavage, use of enterosorbents.

Adverse reactions

From the blood and lymphatic system: decreased hemoglobin content, leukopenia. From the gastrointestinal tract: vomiting, diarrhea.

From the nervous system: headache, increased irritability, insomnia. From the immune system: allergic reactions, including rash, itching, hyperemia.

Best before date

Storage conditions

Store in original packaging at a temperature not exceeding 25 ºС.

Keep out of the reach of children.

Package

10 tablets in blisters.

10 tablets per blister, 3 blisters per pack.

Manufacturer

JSC "KYIV VITAMIN PLANT".

The location of the manufacturer and the address of the place of its activities.

04073, Ukraine, Kyiv, st. Kopylovskaya, 38.

Website: www.vitamin.com.ua.