Mexidol injections: instructions for use. Official instructions for use Mexidol injections

Description and use of the drug

Mexidol is part of a group of drugs with antioxidant properties.
One of their forms of production is a solution for intramuscular or intravenous administration: transparent, can be completely colorless, or with a slightly cloudy tint. The main chemical element is ethylmethylhydroxypyridine succinate. The pharmacological effects of Mexidol injections include the following properties:

It has membrane-protective and antihypoxic, as well as proconvulsant and nootropic effects.
Manifoldly increases a person's resistance to stress.
. Resistance to the negative influence of environmental factors also increases.
. It is excellent at overcoming various oxygen-dependent pathologies: shock of various natures, hypoxia, vascular accidents, tissue ischemia, intoxication with alcohol and antipsychotic drugs.
. There is a significant improvement in cerebral metabolism and blood supply to all tissues.
. The aggregative and rheological parameters of blood elements improve.
. The membranes of blood elements are stabilized.
. There is a significant lipid-lowering effect.

The main positive mechanism of action of Mexidol in injections is associated with its undoubted antioxidant and antihypoxic effects, as well as a membrane-stabilizing effect. The drug improves the activity of superoxide dismutase, inhibits lipid oxidation, reduces membrane viscosity and increases its fluidity, and also modulates the activity of membrane-binding enzymes. Mexidol in injections stabilizes metabolic processes in ischemically disadvantaged areas of the tissues of the heart and brain, improves electrical contractility and activity of the heart muscle, and increases ganglion activity of nitrates.

Indications for use of Mexidol in ampoules

Acute brain catastrophes.
. Consequences of various traumatic brain injuries.
. All kinds of encephalopathy.
. Vegetative-vascular insufficiency syndrome.
. Cognitive decline caused by atherosclerotic plaques.
. As part of a complex for ischemic conditions.
. Open angle glaucoma.
. Relief of withdrawal syndromes
. In case of acute intoxication with antipsychotic drugs.

Mexidol injections are contraindicated for diseases such as:

Acute renal and liver failure.
Increased individual susceptibility to ethylmethylhydroxypyridine succinate.

Mexidol in ampoules for course therapy is prescribed only by a specialist. Strictly controlled observations of its use in pregnant women, during lactation, as well as in children have not been carried out - Mexidol in injections has not been carried out, therefore, in the listed cases, they try to avoid it.

Cost of the drug in pharmacies: Mexidol ampoules 5%, 5 ml, 5 pcs. price 420 rubles, price Mexidol ampoules 5%, 5 ml, 20 pcs. 1600 rubles, price Mexidol ampoules 5%, 2 ml, 50 pcs. 2050 rubles. Mexidol analogs prices: Cecard ampoules 250 mg. 5 ml, 5 pcs. 240 rubles, Mexicor ampoules 50 mg/ml 2 ml, 10 pcs. 325 rubles.

Analogs of Mexidol, which are similar in composition and action, are such drugs as: Mexiprim, Mexicor, Mexidant, Mexifin, Cerecard, Neurox, Medomexi, etc.

Official instructions for use Mexidol injections

Reviews and comments

Oksana

Mexidol injections are in demand not only among older people, but also among young people. I’m thirty-something, but I already have problems with the blood vessels in my head and I’ve begun to react to changes in weather very often. I contacted a specialist and received a referral for a course of Mexidol injections. I carefully read the instructions for using Mexidol in injections and learned that I would then need to take Mexidol in tablets. She did everything conscientiously, although she did not feel any negative sensations either from Mexidol injections or from Mexidol tablets. The product has helped greatly, migraine pains have become less frequent. Reviews from Meksidal were the most favorable.

Andrey V.

After forty years, I began to feel tired, blurred vision, and frequent headaches. I didn’t want to go to the doctor; they’d consider me completely sick, or they’d tell me to go to work. I turned to the Internet in search of medical forums. I came across a description of the action of Mexidol. I carefully read the instructions for Mexidol intramuscular injections, where, by the way, the indications for use are detailed. I looked for analogues of Mexidol in injections, but from reviews I learned that Mexidol in injections was still more effective. After the course, I really felt a surge of strength, my vision gradually improved, I stopped getting tired, and I even began to sleep better. In general, reviews of Mexidol have been good.

Catherine

I had to deal with the unpleasant sensations of dizziness and fatigue; I couldn’t keep up with everything at work and received complaints from my superiors. I went through a medical examination, to be honest, I thought my hemoglobin had dropped again, this has happened before. But laboratory tests were normal. The blood vessels in the head were checked and it turned out that there were abnormalities. The specialist prescribed the drug Mexidol intramuscular injections, explained why it was prescribed and what possible side effects were possible. He added complex vitamins to it, advised him to walk outside more often, and get enough sleep regularly. A month later I felt like a completely healthy person. Mexidol reviews in ampoules are the best. Now I recommend similar courses to my friends, of course, after consultation with a specialist.

Valery

Lately I have been experiencing nervousness, irritability and headaches, especially in the temple area. A friend advised me to inject the medicine Mexidol, but I don’t like injections, so I once again asked a neurologist whether Mexidol tablets or injections are better, the doctor advised injections as the effect will be faster and stronger. The course of treatment was completed in 10 days, during the injections there was slight drowsiness and lightness in the body and head. In general, the reviews for Mexidol injections were positive, but I don’t recommend injecting them all the time, because... addiction occurs.

Latin name

Release form

Tablets, coated from white to white with a creamy tint, biconvex; on a cross section, 2 layers are visible: the inner (core) gray or gray with a creamy tint and the outer white or white with a creamy tint.

Active substance:

ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate) - 125.0 mg

Excipients:

lactose monohydrate - 97.5 mg

povidone - 25.0 mg

magnesium stearate - 2.50 mg

Film casing:

opadry II white 33G28435 - 7.5 mg (hypromellose - 3.0 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg)

Package

10 pcs. - contour cell packaging (5) - cardboard packs.

Pharmacological action

Antioxidant agent.

Pharmacodynamics

Mexidol® is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics (neuroleptics)).

The mechanism of action of Mexidol® is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol® modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission.

Mexidol® increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins.

The anti-stress effect is manifested in the normalization of post-stress behavior, somato-vegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain.

Mexidol® has a pronounced antitoxic effect during withdrawal syndrome. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol®, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects. Mexidol® improves the functional state of ischemic myocardium. In conditions of coronary insufficiency, it increases collateral blood supply to the ischemic myocardium, helps maintain the integrity of cardiomyocytes and maintain their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction.

Pharmacokinetics

Suction

When Mexidol is administered in doses of 400-500 mg, Cmax in plasma is 3.5-4.0 mcg/ml and is achieved within 0.45-0.5 hours.

Distribution

After intramuscular administration, the drug is determined in the blood plasma within 4 hours. The average retention time of the drug in the body is 0.7-1.3 hours.

Removal

It is excreted from the body in the urine mainly in glucurone-conjugated form and in small quantities unchanged.

Indications

consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;

mild traumatic brain injury, consequences of traumatic brain injury;

encephalopathies of various origins (dyscirculatory, dysmetabolic, post-traumatic, mixed);

autonomic dystonia syndrome;

mild cognitive disorders of atherosclerotic origin;

anxiety disorders in neurotic and neurosis-like conditions;

conditions after acute intoxication with antipsychotic drugs;

asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;

exposure to extreme (stress) factors.

coronary heart disease as part of complex therapy;

relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders

Contraindications

increased individual sensitivity to the drug;
acute renal failure;
acute liver failure.

Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Use during pregnancy and breastfeeding

Strictly controlled clinical studies of the safety of the drug Mexidol® during pregnancy and breastfeeding have not been conducted.

Directions for use and doses

Orally, 125-250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets).

Duration of treatment - 2-6 weeks; to relieve alcohol withdrawal - 5-7 days. Treatment is stopped gradually, reducing the dose over 2-3 days.

The initial dose is 125-250 mg (1-2 tablets) 1-2 times a day with a gradual increase until a therapeutic effect is obtained; the maximum daily dose is 800 mg (6 tablets).

The duration of therapy in patients with coronary artery disease is at least 1.5-2 months. Repeated courses (on the recommendation of a doctor) are preferably carried out in the spring and autumn.

Side effects

From the digestive system: rarely - nausea, dry mouth.
Other: rarely - allergic reactions.

The domestic drug Mexidol (active ingredient - ethylmethylhydroxypyridine succinate) belongs to the group of antioxidants. It suppresses the processes of free radical oxidation, has membrane-protective, nootropic, antihypoxic, stress-protective and anxiolytic (anti-anxiety) effects. Mexidol promotes the formation of the body's resistance to the effects of various destructive factors (shock, oxygen starvation, ischemia, poisoning with alcohol, antipsychotics or psychotropic substances, circulatory disorders in the brain). The drug suppresses lipid peroxidation reactions, “inspires” the antioxidant enzyme superoxide dismutase, harmonizes the lipid-protein balance, reduces viscosity and increases the fluidity (rheological properties) of cell membranes. Mexidol controls the functional state of membrane-bound enzymes (adenylate cyclase, calcium-independent phosphodiesterase, acetylcholinesterase), regulates the activity of receptor groups (GABA, benzodiazepine, acetylcholine), increasing their ability to interact with ligands, promotes the inviolability of the structural and functional organization of biological membranes, creates optimal conditions for transport neurotransmitters and improve neurotransmission. The drug increases the concentration of dopamine in the brain, stimulates aerobic glycolysis reactions and compensates for the inhibition of oxidation processes within the Krebs cycle while simultaneously increasing the level of ATP and creatine phosphate under conditions of oxygen starvation, and stimulates energy synthetic reactions in mitochondria. Mexidol regulates metabolic processes in the brain and improves its blood supply, reduces the ability of platelets to aggregate, and stabilizes blood cell membranes during hemolysis.

Along with this, the drug is also endowed with a hypolipidemic effect, which is reflected in a decrease in the level of total and “bad” (LDL) cholesterol.

The anti-stress effect of the drug is expressed in debugging post-stress behavior, eliminating somato-vegetative dysfunctions, restoring normal sleep, improving the ability to learn and remember information, reducing degenerative and structural changes in the brain. Mexidol is a powerful detoxicant for alcohol withdrawal syndrome: it neutralizes the neurological and neurotoxic consequences of acute alcohol poisoning, eliminates behavioral and cognitive disorders caused by long-term alcohol abuse, and restores autonomic functions. The drug potentiates the effect of tranquilizers, neuroleptics, antidepressants, anticonvulsants and hypnotics, which allows the doctor to reduce their dose and to a certain extent reduce the risk of adverse reactions. Mexidol increases the functional activity of ischemic myocardium: against the background of coronary insufficiency, the drug activates its collateral (bypass) blood supply, which helps to protect cardiomyocytes and maintain their performance. The drug is able to restore contractility of the heart muscle in case of reversible cardiac dysfunction.

Mexidol is available in the form of tablets and solution for intravenous and intramuscular administration. The second dosage form is used mainly in hospital settings. Tablets should be taken 125–250 mg 3 times a day. The duration of the medication course is on average from 2 to 6 weeks (for relief of withdrawal symptoms - up to 1 week).

Pharmacology

Antioxidant drug. It has antihypoxic, membrane protective, nootropic, anticonvulsant and anxiolytic effects, increases the body's resistance to stress. The drug increases the body's resistance to the effects of major damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics /neuroleptics/).

Mexidol ® improves cerebral metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the level of total cholesterol and LDL.

Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.

The mechanism of action of the drug Mexidol ® is due to its antihypoxic, antioxidant and membrane protective effects. The drug inhibits the processes of lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces the viscosity of the membrane, and increases its fluidity. Mexidol ® modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol ® increases the content of dopamine in the brain. Causes an increase in the compensatory activity of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions, with an increase in the content of ATP, creatine phosphate and activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

Mexidol ® normalizes metabolic processes in the ischemic myocardium, reduces the necrosis zone, restores and improves the electrical activity and contractility of the myocardium, and also increases coronary blood flow in the ischemic zone, reduces the consequences of reperfusion syndrome in acute coronary insufficiency. Increases the antianginal activity of nitro drugs. Mexidol ® promotes the preservation of retinal ganglion cells and optic nerve fibers during progressive neuropathy, the causes of which are chronic ischemia and hypoxia. Improves the functional activity of the retina and optic nerve, increasing visual acuity.

Pharmacokinetics

Suction

When Mexidol is administered in doses of 400-500 mg, Cmax in plasma is 3.5-4.0 μg/ml and is achieved within 0.45-0.5 hours.

Distribution

After intramuscular administration, the drug is determined in the blood plasma within 4 hours. The average retention time of the drug in the body is 0.7-1.3 hours.

Removal

It is excreted from the body in the urine mainly in glucurone-conjugated form and in small quantities unchanged.

Release form

The solution for intravenous and intramuscular administration is colorless or slightly yellowish, transparent.

Excipients: sodium metabisulfite - 1 mg, water for injection - up to 1 ml.

5 ml - glass ampoules (5) - contour cell packaging (1) - cardboard packs.
5 ml - glass ampoules (5) - contour cell packaging (4) - cardboard packs (for hospitals).
5 ml - glass ampoules (5) - contour cell packaging (10) - cardboard packs (for hospitals).
5 ml - glass ampoules (5) - contour cell packaging (20) - cardboard packs (for hospitals).

Dosage

Mexidol ® is administered intramuscularly or intravenously (stream or drip). To prepare a solution for infusion, the drug should be diluted in 0.9% sodium chloride solution.

Mexidol ® is administered in a stream slowly over 5-7 minutes, drip-wise at a rate of 40-60 drops/min. The maximum daily dose should not exceed 1200 mg.

In case of acute cerebrovascular accidents, Mexidol ® is used in the first 10-14 days intravenously at a dose of 200-500 mg 2-4 times a day, then intramuscularly at a dose of 200-250 mg 2-3 times a day for 2 weeks. .

For traumatic brain injury and the consequences of traumatic brain injury, Mexidol ® is used intravenously for 10-15 days at a dose of 200-500 mg 2-4 times a day.

For discirculatory encephalopathy in the decompensation phase, Mexidol ® is used intravenously in a stream or drip at a dose of 200-500 mg 1-2 times a day for 14 days, then intramuscularly at 100-250 mg/day for the next 2 weeks.

For a course of prophylaxis of dyscirculatory encephalopathy, Mexidol ® is administered intramuscularly at a dose of 200-250 mg 2 times a day for 10-14 days.

For mild cognitive impairment in elderly patients and anxiety disorders, Mexidol ® is administered intramuscularly at a dose of 100-300 mg/day for 14-30 days.

In case of acute myocardial infarction, as part of complex therapy, Mexidol ® is administered intravenously or intramuscularly for 14 days, against the background of traditional therapy for myocardial infarction, including nitrates, beta-blockers, ACE inhibitors, thrombolytics, anticoagulant and antiplatelet agents, as well as symptomatic means according to indications.

In the first 5 days, to achieve maximum effect, it is advisable to administer the drug intravenously; in the next 9 days, Mexidol ® can be administered intramuscularly.

The drug is administered intravenously by drip infusion, slowly (to avoid side effects) in a 0.9% sodium chloride solution or a 5% dextrose (glucose) solution in a volume of 100-150 ml for 30-90 minutes. If necessary, a slow jet injection of the drug lasting at least 5 minutes is possible.

The drug is administered (IV or IM) 3 times a day every 8 hours. The daily therapeutic dose is 6-9 mg/kg body weight/day, a single dose is 2-3 mg/kg body weight. The maximum daily dose should not exceed 800 mg, a single dose - 250 mg.

For open-angle glaucoma of various stages, as part of complex therapy, Mexidol ® is administered intramuscularly at 100-300 mg/day 1-3 times/day for 14 days.

For alcohol withdrawal syndrome, Mexidol ® is administered in a dose of 200-500 mg intravenously or intramuscularly 2-3 times a day for 5-7 days.

In case of acute intoxication with antipsychotic drugs, Mexidol ® is administered intravenously at a dose of 200-500 mg/day for 7-14 days.

In acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis), Mexidol ® is prescribed on the first day both in the preoperative and postoperative periods. The administered doses depend on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. Discontinuation of the drug should be done gradually, only after a stable positive clinical and laboratory effect.

For acute edematous (interstitial) pancreatitis, Mexidol ® is prescribed 200-500 mg 3 times a day intravenously (in isotonic sodium chloride solution) and intramuscularly.

For necrotizing pancreatitis of mild severity, Mexidol ® is prescribed 100-200 mg 3 times a day intravenously (in isotonic sodium chloride solution) and intramuscularly.

For necrotizing pancreatitis of moderate severity - 200 mg 3 times a day intravenously (in isotonic sodium chloride solution).

For severe necrotizing pancreatitis - in a pulse dosage of 800 mg on the first day, with a double dose regimen, then - 200-500 mg 2 times a day with a gradual reduction in the daily dose.

In an extremely severe form of necrotizing pancreatitis, the initial dose is 800 mg/day until the manifestations of pancreatogenic shock are persistently relieved, after stabilization of the condition - 300-500 mg 2 times a day intravenously (in 0.9% sodium chloride solution) with a gradual reduction in the daily dosage.

Overdose

In case of overdose, drowsiness may develop.

Interaction

Mexidol ® enhances the effect of benzodiazepine derivative anxiolytics, antiparkinsonian (levodopa) and anticonvulsant (carbamazepine) drugs.

Mexidol ® reduces the toxic effects of ethyl alcohol.

Side effects

From the digestive system: nausea and dryness of the oral mucosa may occur.

Other: allergic reactions, drowsiness.

Indications

acute cerebrovascular accidents;
traumatic brain injury, consequences of traumatic brain injury;
dyscirculatory encephalopathy;
autonomic dystonia syndrome;
mild cognitive disorders of atherosclerotic origin;
anxiety disorders in neurotic and neurosis-like conditions;
acute myocardial infarction (from the first day) as part of complex therapy;
primary open-angle glaucoma of various stages, as part of complex therapy;
relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;
acute intoxication with antipsychotic drugs;
acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis) as part of complex therapy.

Contraindications

acute liver dysfunction;
acute renal dysfunction;
increased individual sensitivity to the drug.

Strictly controlled clinical studies of the safety of the drug Mexidol ® in children, pregnancy and breastfeeding have not been conducted.

Features of application

Use during pregnancy and breastfeeding

Mexidol ® is not recommended for use during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug's effect.

Use for liver dysfunction

The drug is contraindicated in acute liver dysfunction.

Use for renal impairment

The drug is contraindicated in acute renal impairment.

Special instructions

In some cases, especially in predisposed patients with bronchial asthma with increased sensitivity to sulfites, severe hypersensitivity reactions may develop.

Russian scientists do not stop research, the purpose of which is to prevent diseases associated with the harmful effects of free radicals on the human body. These experiments are aimed at increasing the resistance of organ tissues to oxygen starvation in all types of hypoxia and chronic circulatory disorders. The only drug of its kind, “Mexidol Indications for Use,” received permission for release at the end of the 20th century. It belongs to nootropic drugs that effectively activate metabolic processes, including metabolism in brain tissue.

Release form, composition and packaging

Mexidol has an amazing intense effect on brain cells. The drug transports the required amount of oxygen to neurons through the blood and increases the threshold for the generation of convulsive impulses in the human brain. With the help of Mexidol, the patient quickly restores memory and habitual skills that were lost due to the illness. The cognitive abilities of the brain increase, resistance to intoxication and various stressful situations increases. The anticonvulsant drug is available in tablets and ampoules.

Pills

Mexidol tablets contain the main substance – ethylmethylhydroxypyridine succinate . The auxiliary components of the drug are: sodium carmellose, lactose monohydrate, magnesium streate. The tablet shell consists of macrogol, talc, polyvinyl alcohol, titanium dioxide. The tablets have a round, biconvex shape. They are produced in 10, 30, 50 and 90 pieces in packaging, which can take the form of contour cells made of PVC film, a plastic can or a blister of aluminum foil.

Ampoules

The composition of 1 ml of the drug includes 50 mg of Mexidol and water for injection. Mexidol solution has a clear or slightly yellowish color. Ampoules are available in various capacities: 2 or 5 ml and are packed in five pieces in blister blister packs. Mexidol ampoules are intended for intramuscular injection. The solution is available in light-protected or transparent glass ampoules, with the break point marked in blue or white. The ampoules have three marking rings - red, white and yellow (from bottom to top).

Indications for use of Mexidol

After suffering acute disorders of the blood supply to the brain.
Mild traumatic brain injuries and their consequences.
Dystonia syndrome of vegetative type.
Mild forms of cognitive disorders of atherosclerotic origin.
Encephalopathies of various origins.
Neurotic, anxiety, neurosis-like disorders.
Asthenic conditions.
Alcoholism with concomitant vegetative-vascular or neurosis-like disorders.
Relief of withdrawal type syndrome, post-withdrawal disorders.
Patients after acute intoxication with antipsychotic drugs.
The influence of stress factors on the body.
To prevent the manifestation of somatic diseases due to exposure to extreme factors.
For hemolysis (stabilizes the membrane structure of lymphatic cells).

Contraindications

Pancreatitis.
Acute liver and kidney failure.
Pregnancy and lactation.
Children before reaching adulthood.
People with increased individual sensitivity to the components of the drug.

How to take the drug

According to the insert, the drug in the form of a solution is intended for administration intravenously (through a dropper) or intramuscularly by injection. If the drug is prescribed for intravenous use, the ampoule must be combined with an isotonic sodium chloride solution. Otherwise, Mexidol should be administered by drip infusion; it is assumed that the solution will enter the patient’s body within 5-7 minutes (the rate is 40-60 drops per minute). Moreover, the maximum daily dose should not exceed 120 g.

Tablets are prescribed to the patient with an initial daily dose of 1-2 pieces. Gradually, the amount of the drug taken is increased until the expected effect is achieved. Moreover, the maximum daily dose is 6 tablets. The duration of treatment depends on the individual response of each patient to Mexidol. It often lasts from two weeks to 45 days. If the pills were prescribed to relieve symptoms of alcohol withdrawal, the course duration is no more than a week

Dosage

Mexidol indications for use:

Orally Mexidol is prescribed up to 800 mg per day, the average dose is 125-250 mg. The duration of treatment with tablets ranges from 14 to 45 days, depending on the severity of the patient’s condition. The course duration for patients with coronary heart disease is at least 1.5 months. Treatment with tablets is stopped gradually, reducing the daily dosage.
Injections begin with a dose of 0.05-0.1 grams up to three times a day. Gradually the amount of the administered drug increases. The duration of treatment and determination of the daily dose depend on the patient’s condition and tolerability of the drug. The maximum daily dose is 0.8 grams of solution. For the treatment of patients with atherosclerotic dementia, Mexidol is used in a daily dose of 0.1 to 0.3 mg. If the patient is diagnosed with “acute intoxication with antipsychotic drugs,” 0.3-0.5 mg of solution is administered intravenously.

Side effects

Dry mouth, nausea.
Allergic reactions.
Weakness, drowsiness.
Discomfort in the stomach.
Unstable chair.
Heartburn, bloating.
Appetite disorder.
Loss of coordination.
Emotional reactivity.
Decreased blood pressure.
Sleep problems.

Storage conditions and shelf life

Mexidol must be stored in a dry, dark place (do not expose the drug to direct sunlight). The storage location must be inaccessible to children or animals. The optimal temperature is 25 degrees. If you decide to store Mexidol in the refrigerator, use a specially designed compartment on the door and, before placing the tablets or solution there, provide the drug with additional protection from moisture (for example, by placing the packaging in a bag). The solution, like the tablets, is suitable for use for three years from the date of manufacture.

Price

The price of a 5% solution for injection with a volume of 50 ml (10 ampoules) is 430 rubles.
5% Mexidol solution (20 ampoules) – 1500 rubles.
5% solution (50 ampoules) – about 2000 rubles.
Mexidol tablets (30 pcs.) – 200 rubles.
Tablets (50 pcs.) – 350 rubles

Antioxidant drug

Active ingredient

Ethylmethylhydroxypyridine succinate

Release form, composition and packaging

Film-coated tablets from white to white with a creamy tint, round, biconvex.

Excipients: lactose monohydrate - 97.5 mg, - 25 mg, magnesium stearate - 2.5 mg.

Film shell composition: opadry II white 33G28435 - 7.5 mg (hypromellose - 3 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg).

10 pcs. - contour cell packaging (1) - cardboard packs.
10 pcs. - contour cell packaging (2) - cardboard packs.
10 pcs. - contour cell packaging (3) - cardboard packs.
10 pcs. - contour cell packaging (4) - cardboard packs.
10 pcs. - contour cell packaging (5) - cardboard packs.

Pharmacological action

Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics /neuroleptics).

The mechanism of action of the drug Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. The drug inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol increases the content in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

Mexidol has a pronounced antitoxic effect in withdrawal symptoms. Eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Mexidol improves the functional state of ischemic myocardium. In conditions of coronary insufficiency, it increases collateral blood supply to the ischemic myocardium, helps maintain the integrity of cardiomyocytes and maintain their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction.

Pharmacokinetics

Suction and distribution

Rapidly absorbed when taken orally. Cmax at doses of 400-500 mg is 3.5-4.0 mcg/ml.

Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9-5.2 hours.

Metabolism

Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphate, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and found in urine 1-2 days after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuron conjugates.

Removal

T1/2 when taken orally - 2-2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. The rates of urinary excretion of unchanged drug and metabolites have individual variability.

Indications

- consequences of acute cerebrovascular accidents, incl. after transient ischemic attacks, in the subcompensation phase (as preventive courses);

- mild traumatic brain injury, consequences of traumatic brain injury;

- increased individual sensitivity to the drug.

Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Dosage

Orally 125-250 mg 3 times/day; the maximum daily dose is 800 mg (6 tablets). Duration of treatment - 2-6 weeks; For relief of alcohol withdrawal- 5-7 days. Treatment is stopped gradually, reducing the dose over 2-3 days.

Initial dose - 125-250 mg (1-2 tablets) 1-2 times/day with a gradual increase until a therapeutic effect is obtained; the maximum daily dose is 800 mg (6 tablets).

The duration of therapy in patients with coronary artery disease is at least 1.5-2 months. It is advisable to carry out repeated courses (on the recommendation of a doctor) in the spring and autumn.

Side effects

Individual adverse reactions may occur: dyspeptic, allergic reactions.

Overdose

In case of overdose, drowsiness may develop.