Glucosamine-chondroitin complex for the treatment of joints and spine. A useful dietary supplement with a unique set of active substances - Chondroitin Glucosamine: instructions for use, price, reviews, analogues of the combined product

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Glucosamine and Chondroitin - complex intended for the treatment of joints. A product containing such components is not considered a medicinal product; therefore, it is classified as a dietary supplement consumed with food.

The main purpose of such drugs is in the active enrichment of the patient’s body with necessary beneficial elements, responsible for the performance of the spine and joints. In this article we will find out what Chondroitin and Glucosamine are, what preparations contain these components, as well as in what dosages and for what diseases they should be taken.

Release forms

Capsules

Glucosamine + Chondroitin MSM

Ask your question to a neurologist for free

Irina Martynova. Graduated from Voronezh State Medical University named after. N.N. Burdenko. Clinical resident and neurologist of the BUZ VO \"Moscow Polyclinic\".

It is produced in the form of capsules intended for oral use. Capsules are produced in sealed packages located in a small cardboard box. One package may contain 60 or 90 capsules. Glucosamine + Chondroitin MSM should be taken by athletes, elderly people and overweight patients.

The active components of the Glucosamine + Chondroitin MSM complex include chondroitin sulfate and glucosamine sulfate.

The price for 60 capsules is 250 rubles and above.

The cost of 90 capsules is 350 rubles.

Tianshi glucosamine capsules

The drug belongs to the food additives. It contains natural components that protect joints and cartilage. Stimulates the production of glucosamine, restores cartilage tissue. Available in the form of capsules in a package weighing 400 milligrams.

The active components of the drug include: glucosamine hydrochloride, chondroitin sulfate, calcium carbonate and collagen.

The cost of one package is 1363 rubles or more.

Glucosamine Chondroitin complex

Effectively acts on the human body. Eliminates pain in joints, spine and tissues. Has a beneficial effect on ligaments. Can be used to normalize calcium-phosphorus metabolism. Easily increases the level of intra-articular fluids. Available in capsule form. Athletes and overweight people need to take Glucosamine Chondroitin Complex.

Glucosamine Chondroitin complex contains 1500 ml of glucosamine sulfate and 1200 ml of chondroitin sulfate, which are made from cattle cartilage. The drug also contains potassium, sodium, manganese and vitamin C.

The cost of such a complex is 1,440 rubles and more.

Doppelgerz Active Glucosamine + Chondroitin

Doppelhertz Active Glucosamine + Chondroitin is a dietary supplement. Can be used as sports nutrition. It is used as a preventive measure to prevent pain in joints and tissues. May affect the body's metabolic processes. Doppelhertz Active Glucosamine + Chondroitin is an antiseptic and anti-inflammatory agent. Available in capsule form.

Doppelgerz Active Glucosamine + Chondroitin contains vitamin E and polyunsaturated fatty acids.

The cost of the drug is 390 rubles and more.

Honda Forte Evalar is available in the form of capsules (30 pieces), powder for preparing a suspension and as a cream in a 50 g tube. The drug is prescribed for regular high loads on the joints. The product is used by patients who are overweight or subject to constant stress. The medicine stimulates collagen synthesis and has an anti-edematous and anti-inflammatory effect.

The drug contains glucosamine hydrochloride and chondroitin sulfate.

Cost: 646 rubles for 30 capsules.

The product improves the performance of cartilage tissue. The drug, used in sports and medicine, can have an anti-inflammatory effect. Available in the form of a clear gel or ointment. Has a pleasant fruity aroma. Designed for outdoor use.

Chondroxide contains sodium chondroitin sulfate, lanolin, dimethyl sulfoxide, and distilled monoglycerides.

The cost of the ointment is 385 rubles.

Pills

Artra

The medicine belongs to the group of combined action chondroprotectors. Easily has a restorative effect on the cartilage tissue of joints. Participates in the restoration processes of connective tissue, stimulates the production of collagen. Effervescent tablets are available in high-density polyethylene bottles, which are packaged in cardboard boxes. One package contains 30, 60, 100 or 120 tablets.

The active components of the medicine include sodium chondroitin sulfate and glucosamine hydrochloride.

The cost of 30 tablets is 1006 rubles and more.

The price of 60 tablets is 1628 rubles or more.

A pack of 100 tablets will cost 2,180 rubles.

A package of 120 tablets costs just over 2,609 rubles.

Glucosamine Plus

One pack of the drug contains 60 hermetically sealed tablets. The drug improves the structure of cartilage tissue, increases elasticity, and normalizes the concentration of intra-articular fluid. Eliminates any diseases of the musculoskeletal system. Can be used as sports nutrition.

Contains chondroitin and glucosamine in the form of sulfates.

The price of the drug is 1300 rubles.

Drugs in ampoules

Dona is produced in the form of tablets, a liquid solution in ampoules and in the form of a powder for the preparation of a solution for injection. The drug is able to regulate metabolism in cartilage tissue. Used for osteoarthritis and osteochondrosis. Don's drug is contraindicated in people with renal failure. Not recommended for teenagers and pregnant women.

Dona contains glucosamine in the form of sulfate. Microcrystalline cellulose, povidone, croscarmellose sodium, macrogol, talc and magnesium stearate are added as additional components.

The cost of Don's drug is 1,650 rubles and more.

B-complex Solgar

The drug is a food additive. Does not contain shellfish or dairy products, therefore it is intended for both ordinary patients and hypersensitive people and allergy sufferers. Easily eliminates pain in ligaments and joints, helps increase range of motion. It comes in the form of tablets that must be taken with meals.

Preparations containing glucosamine and chondroitin, in addition to the main components, also contain hyaluronic acid and a complex of vitamins.

The cost of Solgar preparations containing glucosamine with chondroitin ranges from 1280 to 4354 rubles.

Preparations in powder form

Artrakam

The drug is produced in the form of Artracam tablets. An analogue of Artracam is a crystalline powder. It can be snow-white or have an amber tint. The drug is a tissue repair stimulator. Instructions for use prescribe taking the medicine for inflammatory and degenerative diseases of the joints and spine. Artracam is sold in sealed bags in the form of a powder for the preparation of a suspension.

Artracam contains active ingredients in the form of glucosamine sulfate and sodium chloride. Citric acid and sorbitol are also added to the medicine.

The price of Artracam may vary depending on the markups of retail chains. The cost is 972 rubles and above.

All preparations contain glucosamine and chondroitin. The difference between the drugs lies in the form of release, dosage, and cost. Capsules should be taken orally with food. Take the tablets with a small amount of water and swallow them before meals. Creams and ointments are rubbed into the skin with light massaging movements.

Expert opinion

Filimoshin Oleg Alexandrovich

Doctor - neurologist, city clinic of Orenburg. Education: Orenburg State Medical Academy, Orenburg.

All drugs have an anti-inflammatory effect, regulate metabolism in cartilage tissues.

Indications for use

Chondroitin Glucosamine MSM should be taken by the following categories of patients:

Athletes;
Overweight patients;
Elderly people over 50 years of age;
Representatives of professions whose activities involve excessive physical activity.

It is these categories of citizens most at risk of getting dislocations, fractures. In such people, cartilage tissue may rupture or be undernourished. Therefore, as a preventative measure, it is necessary to take the Chondroitin Glucosamine MSM complex or its analogues containing these active components.

The drugs are also prescribed to people with the following diseases:

osteoarthritis;
arthropathy;
spondylosis;
injuries to joints and bones.

Expert opinion

Mitrukhanov Eduard Petrovich

Doctor - neurologist, city clinic, Moscow. Education: Russian State Medical University, State Budgetary Educational Institution of Further Professional Education, Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation, Volgograd State Medical University, Volgograd.

Drugs have a beneficial effect on the performance of muscles, bones, cartilage and joints.

Contraindications

The use of drugs is contraindicated in the following cases:

With a tendency to bleeding of the gastrointestinal tract.
Developed thrombophlebitis.
Diabetes mellitus.
Impaired functioning of the liver and kidneys.
Phenylketonuria.
Hypersensitivity and allergies.

Dosages

The course of taking any of the above remedies is 30 days. In one year, three to four full-fledged courses can be conducted. The daily dosage for a typical patient is 1500 milligrams. This dosage can be divided into two or three doses. Any remedy is taken with food - this way the active ingredients are absorbed much better and faster.

Therefore, such people need to know how to take the medicine:

If you weigh less than fifty kilograms, you need to take 800 milligrams of chondroitin and 1000 milligrams of glucosamine.
If you weigh more than fifty but less than ninety kilograms, you should take 1500 milligrams of glucosamine and 1200 milligrams of chondroitin.
If you weigh more than ninety kilograms, the recommended dosage is 2000 milligrams of glucosamine and 1600 milligrams of chondroitin.

Overdoses and side effects

With long-term use of drugs or with their increased dosages, patients experience:

dizziness;
headaches;
migraine;
constipation;
diarrhea;
stomach upsets and acute intestinal colic;
rash on the skin;
increased gas formation;
swelling;
pain in the limbs;
tachycardia;
increased risk of diabetes.

Be sure to watch the video about side effects

Interaction with other drugs

The simultaneous use of steroid or anti-inflammatory drugs is allowed. Additional therapy with potassium, magnesium, minerals and vitamins can also be carried out.

The simultaneous use of antibiotic therapy with tetracycline drugs is allowed. This increases the level of absorption of both drugs. The use of glucocorticosteroids is permitted.

But it is worth considering that the drug can reduce the effectiveness of penicillin antibiotics.

Application nuances

The drugs are not recommended for pregnant and lactating women. Any medications negatively affect the health and development of the fetus.
The medicine is not recommended for infants and adolescents under twelve years of age. If it is necessary to use drugs for children over thirteen years of age, consultation with a specialist is necessary.
The funds must be taken by elderly people over fifty years of age. The drugs reduce bone fragility and reduce the likelihood of injury. Dosages are calculated in the same way as for ordinary patients, but before use you must consult your doctor.

Storage and release from pharmacies

Most medications intended for joints and containing glucosamine and chondroitin Sold only with a doctor's prescription. The shelf life of the drugs is from two to three years. Once opened, creams and gels must be used up within one to two months. After opening the ampoules, the drugs are stored for no more than twelve hours. The recommended storage temperature is 15-25 °C.

Medicines such as glucosamine sulfate (GS) and chondroitin sulfate (CS) are the most important substances that help joints with such difficult diseases as osteochondrosis (spondylosis) and especially with deforming osteoarthritis (arthrosis). Thanks to their use, the formation of cartilage tissue in diseased joints is improved, pain and inflammation in them are reduced.

In this article you will learn about what substances glucosamine chondroitin are, how they act in the body, what medications and food components they contain, and what any patient with deforming osteoarthritis needs to know about them in order to keep their joints healthy for as long as possible.

Glucosamine: the most important building material for cartilage tissue

The substance glucosamine is produced by cartilage tissue cells - chondrocytes.

In its structure, glucosamine is a monosaccharide, that is, a relatively small molecule, which, in turn, is an indispensable “building material” for another chondroprotector - chondroitin. Therefore, when there is a lack of GS in the body, the formation of chondroitin is also inhibited.

Why is GS needed and what are its functions in the body?

Glucosamine, which is found in the body mainly in the form of glucosamine sulfate, affects the health of cartilage tissue in several ways:

first of all, this substance promotes the formation (synthesis) of articular cartilage;
affects the cells of the synovial membrane of the joints, increasing metabolism in them and thereby improving the nutrition of cartilage tissue;
reduces pain in deforming arthrosis;
increases mobility in joints, thereby restoring their functions;
HS also affects bone tissue, slowing down the leaching of calcium from bones and increasing their strength due to the accumulation of this important mineral for the body;
helps the formation of an important compound for our body called chondroitinsulfuric acid.

Thus, glucosamine sulfate is important for improving metabolism not only in joints, but also in all connective tissue of the body, including bone tissue. Due to the listed functions of this medicine, it is used primarily for arthrosis - knee, shoulder, and many others.

Active glucosamine is used simultaneously as a means of reducing inflammation in the joints (along with), as a chondroprotector that improves the formation of cartilage, and as a medicine that reduces pain in the articular joints.

At the same time, the clinical effectiveness of this medicine is still unproven, therefore, in some countries, drugs containing GS are classified not as medicines, but as biologically active food additives.

What medications contain

Glucosamine sulfate is included in such drugs as Elbona, Ellastenga, Sustilak, glucosamine, Chondroxide. In these medications, the drug is presented as a mono drug, that is, without chondroitin sulfate. You can read more about these, as well as other chondroprotective medications, in the article, as well as in the material. The same articles contain information about the price of these drugs.

The drug is available in a variety of dosage forms:

powders for dilution with water and oral administration;
solution for intramuscular injection;
tablets for oral administration;
in form for external use.

Which of these forms works better? There is no clear answer to this question yet, but it is generally accepted that the absorption of the drug when administered in the form of injections is higher than when taken orally. At the same time, scientists have now learned to produce this drug in such forms that even when taken in tablet form, a significant amount of this chondroprotector is well absorbed.

We invite you to watch an interesting video about the main chondroprotectors:

Chondroitin sulfate: the number one substance for joints

Chondroitin sulfate is a chemical compound that is also synthesized by cartilage cells. CS is a polysaccharide, a huge molecule of which glucosamine is an integral part.

Like many polysaccharide compounds, chondroitin sulfate has mucous properties, due to which the synovial fluid in the joint cavity ensures smoother and more even sliding of the articular surfaces, and also retains precious moisture in the joint fluid.

Useful properties and functions

Chondroitin sulfate has several very important functions for the normal functioning of connective tissue, primarily bones and joints:

slows down the destruction of cartilage tissue;
enhances the formation of synovial fluid in the joints;
increases the range of motion in joints affected by arthrosis and reduces pain in them;
has an anti-inflammatory effect on joint tissues;
improves cartilage restoration;
helps improve calcium-phosphorus metabolism in connective tissue;
slows down the “leaching” of calcium from bones;
stimulates the formation of glycosaminoglycans, beneficial for connective tissue, as well as hyaluronic acid.

Thanks to all these beneficial functions, chondroitin sulfate is an indispensable substance for the normal functioning of connective tissue, especially cartilage and joints.

If the body produces it in insufficient quantities, then it must be supplied from the outside in “ready” or partial form. For these purposes, connective tissue used in food is best suited, including animal and fish cartilage. It is these foods that contain cholesterol and GS in large quantities.

But, since there is little such food in the diet of a modern person, for joint diseases, especially arthrosis, medications containing chondroitin sulfate are prescribed.

Despite the fact that the clinical effectiveness of both of these chondroprotectors has not yet been fully proven, and the therapeutic effect of cholesterol remains controversial, the use of this substance, at least in the form of dietary supplements, is well proven.

What medications contain

Medicines containing the drug chondroitin sulfate include such drugs as Chondrolone, Structum, Chondroitin-AKOS, Chondroxide and others.

These medications are produced both in the form of tablets for oral administration, and in the form of solutions for intramuscular injection, as well as in the form of cream (Chondroxide).

What is important for the patient to remember

Let's summarize. So, as you can see, chondroitin sulfate and glucosamine sulfate are substances that are extremely important for our body, as they help the normal functioning of connective tissue, primarily cartilage and joints. These compounds are especially important in severe diseases, such as osteochondrosis.

Therefore, if the first signs of such diseases occur, consult a competent arthrologist or rheumatologist as soon as possible. He will prescribe the necessary treatment, which may include various chondroprotectors containing chondroprotectors of both natural origin (or) and artificially synthesized analogues - Artra, Teraflex, Dona and others.

The earlier such treatment is started, the greater the chance that the disease can be stopped at earlier stages, keep the joints healthy and avoid severe and.

Formula: C6H13NO5 + n, chemical name: 2-Amino-2-deoxy-beta-D-glucopyranose + Chondroitin-4-(hydrogen sulfate) (as sodium salt).
Pharmacological group: correctors of cartilage and bone tissue metabolism in combinations.
Pharmacological action: anti-inflammatory, chondroprotective, stimulating the regeneration of cartilage tissue, analgesic, chondrostimulating.

Pharmacological properties

Stimulates the restoration of cartilage tissue. Chondroitin sulfate and glucosamine are involved in the formation of connective tissue and help prevent cartilage destruction. The use of exogenous glucosamine stimulates the formation of cartilage matrix and protects cartilage from chemical damage. Glucosamine, as a sulfate salt, is a precursor to hexosamine, and the sulfate anion is needed for the production of glycosaminoglycans. Another possible property of glucosamine is protection against the metabolic destruction of damaged cartilage that is caused by glucocorticosteroids and non-steroidal anti-inflammatory drugs, as well as the presence of its own moderate anti-inflammatory effect. Chondroitin sulfate is an additional substrate for the synthesis of healthy cartilage matrix, whether it is supplied to the body as separate components or as an intact form. Enhances the synthesis of proteoglycans, hyaluronon and collagen type 2, protects hyaluronon from breakdown by enzymes (the activity of the hyaluronidase enzyme is suppressed) and from the negative effects of free radicals; maintains the viscosity of the joint fluid, enhances cartilage repair and reduces the activity of enzymes involved in the breakdown of cartilage (hyaluronidase, elastase). During the treatment of osteoarthritis, it reduces the manifestation of the disease and also reduces the need for taking non-steroidal anti-inflammatory drugs. The bioavailability of glucosamine when taken orally is 25% (due to first-pass effects through the liver). Distributed in tissues: maximum concentrations are found in articular cartilage, kidneys and liver. Approximately 30% of the dose taken persists for a long time in muscle and bone tissue. It is mainly excreted unchanged in urine, a little in feces. The half-life is 68 hours. When taken orally 0.8 grams (or 0.4 grams 2 times a day), the plasma content of chondroitin sulfate increases during the day. Absolute bioavailability is 12%. About 20 and 10% of the dose taken are absorbed as low molecular weight and high molecular weight derivatives, respectively. The apparent volume of distribution is approximately 0.44 ml/g. During desulfurization processes it is metabolized. Excreted in urine. The half-life is 310 minutes.

Indications

Osteoarthritis grades 1–3.

Method of use of glucosamine + chondroitin sulfate and dose

The drug is taken orally 20 minutes before meals with a glass of water. Adults and children over 15 years of age: 2 – 3 times a day, 2 capsules (at the rate of glucosamine sulfate 250 mg + chondroitin sulfate 200 mg per capsule); The duration of therapy is 1–2 months; if necessary, the course of treatment can be repeated.
If you miss the next dose of the drug, take it as you remember, then take it after the time specified by the doctor from the last use. If undesirable effects from the digestive system appear, the dose of the drug should be reduced by 2 times, and if there is no improvement, then the drug should be discontinued. If there are no clinical effects when taking 4 capsules per day for 4 weeks, then the diagnosis needs to be clarified.

Contraindications for use

Hypersensitivity, phenylketonuria.

Restrictions on use

No data available.

Use during pregnancy and breastfeeding

The use of the drug is contraindicated during breastfeeding and pregnancy.

Side effects of glucosamine + chondroitin sulfate

Glucosamine: disruption of the digestive system (epigastric pain, diarrhea, flatulence, constipation), allergic skin reactions, headache, peripheral edema, leg pain, dizziness, insomnia, drowsiness, tachycardia. Chondroitin sulfate: allergic reactions.

Interaction of glucosamine + chondroitin sulfate with other substances

Increases the absorption of tetracyclines, reduces the effects of semisynthetic penicillins. Compatible with glucocorticosteroids and non-steroidal anti-inflammatory drugs.

Overdose

Cases of overdose are unknown. If this occurs, it is necessary to rinse the stomach and carry out symptomatic treatment.

Trade names of drugs with the active ingredient glucosamine + chondroitin sulfate

Part of the complexes Glucosamine + Ibuprofen + Chondroitin sulfate, Glucosamine + Chondroitin sulfate + Vitamin E

“Artronormin”, aka “Valentin Dikul Complex”, aka “Arthrotsin”, aka “Balm Artrovel”, aka “Collagen Ultra Plus”, aka “Horse Dose for the Body”, aka “Sabelnik”, aka “Sofya with bee venom”, also known as “Sustavit bischofite”, “Sustavod”, “Honda”, “Ellastenga”, and even the mysterious “Sustamed Toad foot stone”. Here is a far from complete list of manufacturers and drugs. All of them include a complex of glucosamine and chondroitin in their dietary supplements. Gels, ointments, tablets, capsules are produced...

If we are talking about world leaders in the production of drugs, for example, Glaxo Smith Klein, Pfizer, Boehringer Ingelheim, Janssen Cilag, then most likely we mean original drugs. These pharmaceutical giants are well positioned to spend money on finding a substance, assessing its effectiveness, toxicity and safety, developing production technology, conducting clinical trials and marketing campaigns.

There are manufacturers that are not of such a high level. These include almost all domestic pharmaceutical production holdings and concerns operating as packaging plants. For this purpose, an imported substance, Indian or Chinese, is purchased. If its quality is decent, then a “branded generic” is released. If not very well, then a generic “according to the INN”. The declared so-called “bioequivalence” allows such production of generics to begin.

But there is a third group - manufacturers of dietary supplements, or “dietary supplements”. They are not registered as medicines. Their active ingredients may contain complex plant materials, or substances with unproven effectiveness, or substances in extremely small doses (homeopathy).

If there is a “sweet spot” for manufacturers of nutritional supplements that have no basis, it is joint diseases and the ubiquitous “osteochondrosis”. Joint pathology is very convenient for manufacturers of dietary supplements: people are sick all their lives, osteochondrosis has not yet led to death or emergency hospitalization in intensive care, and therefore, if the drug is ineffective, manufacturers are not threatened with lawsuits.

A typical example of such a “remedy” is chondroitin with glucosamine for joints. What do the manufacturers promise (and there are a lot of analogues of the complex)?

Glucosamine – chondroitin: how does it work?

The drug is positioned as a “joint protector”

First of all, there is no “original” drug - both glucosamine and chondroitin, and their combination in one complex. All these substances are a component of human cartilage tissue, and have long been known to scientists. Therefore, if a pharmacy tries to sell you “original” glucosamine, then with the same degree of probability you can hope that they will show you the original and genuine, true water.

Critical part

Of course, there is a concept - replacement therapy. In some cases (for example, with insufficiency of the adrenal cortex, thyroid gland, or lack of insulin), lifelong medication is required. Avoiding insulin injections for type 1 diabetes will sooner or later lead to ketoacidosis, diabetic coma and death. Refusal to take glucosamine and chondroitin for a variety of joint diseases will not only not make you feel worse - you just won’t feel anything. Why? But because these substances, introduced from the outside, do not have a proven mechanism of action.

The fact is that the components of cartilage tissue taken in capsules and tablets in the stomach and intestines are broken down into shorter molecules, and there is no guarantee that the same molecule is then synthesized from them.

In addition, it has not been proven that a substance taken orally (through the mouth), which is an integral part of cartilage, after some time in the human body enters the very cartilage that the manufacturer so proudly claims to restore. And, by the way, identifying this is very, very simple. It is enough to “tag” the chondroitin and glucosamine molecule with a radioactive tracer - an isotope with a half-life of a month or so. Then, after 2 - 3 weeks of use, perform scintigraphy and see if there are zones of condensation of “flashes” of isotopes near the joints. This will immediately allow you to prove the most important thing - the drug for the treatment and restoration of damaged joints goes where it is needed!

But all manufacturers are embarrassedly silent. Occasionally, authoritative objections are heard that “modifying the molecule will destroy its healing properties.” In other words: “we’re already making good money from you, why should we do anything else?”?

By the way, the most authoritative organization, the FDA in the USA, still does not recognize, for example, glucosamine as a drug, but has reserved for it the status of a food additive. A large study was conducted in the USA for 4 years, from 2002 to 2006, and it did not reveal the effectiveness of the combination of glucosamine and chondroitin, which was statistically significantly different from placebo.

Structural part

And yet, there are studies that have shown that the administration of chondroitin (more precisely, chondroitin sulfate) for a long time increases joint mobility and reduces pain. Of course, this cannot be considered an objective indicator, since this drug is used in complex therapy, together with non-steroidal anti-inflammatory drugs.

But in the human body, our “native” chondroitin strengthens ligaments and joints, improves the synthesis of synovial fluid (hyaluronic acid), and improves the elasticity of cartilage, since it is able to retain water. In addition, chondroitin inhibits the action of substances that destroy cartilage tissue.

Indications for use

What does the glucosamine-chondroitin complex help with? According to the manufacturers, any joint pathology is an indication for use. This:

arthritis, osteoarthritis;
synovitis, tendonitis, tendovaginitis;
arthrosis, including deforming arthrosis;
arthrosis with an inflammatory component, or arthrosis;
pathology of intervertebral discs - osteochondrosis, protrusion and even disc herniation.

In addition, manufacturers assure that every healthy person should take the glucosamine-chondroitin complex as a means of preventing aging of the musculoskeletal system. However, despite active advertising, more and more operations on endoprosthetics of intervertebral discs and hip joints are being performed around the world...

Instructions for use of glucosamine - chondroitin

The number of drugs that contain the glucosamine-chondroitin complex is very large. But, as a rule, these are either capsules for oral administration, or products for topical use - gels and creams. It is recommended to use it orally, depending on the dosage, twice or thrice a day, after meals, and for a long time. The average course of treatment, for example, for deforming osteoarthritis of the knee joint, is, on average, 2 – 3 months.

This is very beneficial for manufacturers: if you start taking a drug containing glucosamine - chondroitin, then it makes no sense to stop after a week or two, because in this case you will waste your money. Manufacturers are silent about the answer to the question of whether we will waste money if we take the product for three months, but they strongly recommend doing just that.

If a cream or gel is used, it is also recommended to rub it into the joints and back twice or thrice a day. If we take into account all the additives, for example, leech extract, badger and shark oil, bischofite and bee venom, then the dosage regimen and frequency of use vary significantly, depending on the manufacturer, existing indications and complaints.

Contraindications and side effects

Since both glucosamine and chondroitin are contained in large quantities in ordinary jellied meat, they can be consumed for a long time, and in large quantities, without worrying that the use of glucosamine-chondroitin tablets may cause health problems.

Of course, if you use a cheap drug and in large quantities, the degree of purification may not be sufficient. Then abdominal pain, bloating, flatulence, and bowel dysfunction may occur. If you have an allergy, hives and itchy skin may occur.

Serious manufacturers indicate that a contraindication for the use of glucosamine is a disease such as phenylketonuria.

Analogs and generics

As already indicated, the terms “analogs” are not applicable to such a set of substances, which are, in fact, food additives, since no one is the discoverer and creator of these compounds - glucosamine and chondroitin. It is for the same reason that the term “generics” cannot be used, since there is no original drug. What is there? A variety of complexes and recipes that contain both pure substances and in combination with other plant, mineral and animal components.

It goes without saying that all these “analogs” of glucosamine - chondroitin have different instructions for use, since there is no reference standard, very different prices, and reviews, especially in free newspapers that are distributed on the streets, are the most positive.

Thus, according to data as of July 2017, “Teraflex” could be purchased at a price of 2900 for 200 capsules. The dosage regimen requires taking 3 capsules per day for 3 weeks, and then 2 capsules. Thus, the package will last for approximately 2 months of use. Cheap complexes, which cost 200 rubles each, not only contain half as many capsules, but often each capsule contains half as many active ingredients.

In conclusion, I would like to say that, for example, carbamazepine, which has proven effectiveness in epilepsy, can be produced and sold in nondescript packaging, and it will be bought because people need it. And almost all products related to chondroprotectors, “protectors” of cartilage tissue, are packaged very luxuriously. And, according to the laws of human psychology, the more money spent on such a drug, the greater the feeling that it “really helped.” The choice is yours.

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In addition to a description of the glucosamine and chondroitin complex and its properties, there are instructions for use with this drug. With proper use of a dietary supplement, a person will receive specific benefits for the body.

About glucosamine

Glucosamine is a molecule that contains an amine and glucose. The main component of articular cartilage. The aminosaccharide is present in food, but in small quantities. Therefore, the substance is formed by cartilage cells independently.

The component strengthens and supports ligaments and joints, making them strong and resistant to sprains. Glucosamine forms and strengthens the tissue of tendons, muscles, skin, bones, heart valves, blood vessels. Protects the body's immune system, participates in the synthesis of enzymes and hormones.

About chondroitin

An important component of cartilage tissue is chondroitin. But what is it? Polysaccharide is an ordered element of a protein molecule that makes cartilage elastic, wear-resistant, and prevents its degeneration.

It is considered a valuable component of cartilage tissue. Like glucosamine, it is part of the synovial fluid of joints. Chondroitin retains water and inhibits enzymes that destroy cartilage. Enhances the production of hyaluronic acid and collagen. Found in tendons, bone marrow and skin.

Chondroprotectors are stored at temperatures up to 25°C in a dry place inaccessible to children. Shelf life - 36 months after the date of manufacture.

Second generation of chondroprotectors

Glucosamine and chondroitin are a complex of dietary supplements that are not classified as medicines. It is used in the prevention and treatment of the musculoskeletal system, to improve performance in bodybuilding and sports. In addition to other components, the complex contains methylsulfonylmethane - msm.

The organosulfur compound, methylsulfonylmethane, is found in small parts in human blood. Participates in the formation of immunoglobulin, collagen, enzymes. Maintains acid-base balance. Activates vitamins B and C.

It is an anti-inflammatory agent, restores cartilage tissue. Along with chondroitin and glucosamine, it is included in a set of products for the treatment of ligaments and joints.

Useful properties

has a positive effect on the appearance of skin and nail plates;
renews the structural parts of tissues and cells;
heals damaged cartilage tissue;
affects the metabolism of articular cartilage;
relieves tension and pain in joints;
improves the activity of the heart and circulatory system;
participates in the circulation of the arterial vascular bed;
reduces joint stress;
stimulates the formation of bone tissue and the process of mineralization;
accelerates wound healing.

Who needs

Chondroprotectors support and treat cartilage and connective tissue, joints. Used as a wound healing and anti-inflammatory agent.

It is used in the treatment of osteochondrosis and parts of the spine, osteoporosis, spondylosis. Promotes rapid healing of fractures. Facilitates the patient's condition with polyarthritis and bursitis, inflammation of the tendons.

The complex of compounds is designed not only for ordinary people, but also for athletes and bodybuilders. On the shelves of specialized stores you can find sports nutrition that includes chondroprotectors.

The drug has also found its way into cosmetology: it rejuvenates and tightens facial skin, fights pigmentation. Strengthens the hair follicle and prevents hair loss.

Forms

There are five forms of the drug on the Russian market:

Liquid (injection). Better absorbed in the body. Inconvenient to store and transport. It is difficult to calculate the dose of medicine.
Powder. Well absorbed. Often found on shelves.
Capsules. It is convenient to take and calculate the dose of the drug. There are two types of shells: gelatin and cellulose.
Pills. Easy to transport, store and consume. The only negative is that it is less easily absorbed by the body.
Gels or ointments. In addition to the main components, the composition includes additional elements - cinquefoil extract, D-panthenol, essential oils. The disadvantage of the product is that it penetrates the skin slowly.

Dosage

For the average person, the daily requirement is 1000-1500 mg. It is recommended to divide the dosage into two or three doses, i.e. 330-500 mg. For some categories of citizens, the daily dose of the drug is calculated depending on weight.

The dose of chondoprotectors for athletes is 1500-2000 mg. Receiving the drug is distributed throughout the day. With increasing load or during rehabilitation after injuries, the rate increases. In the latter case, it is recommended to consult a personal trainer and a doctor.

The first improvements in the condition are noticeable after 7-14 days, but you should not stop there. The duration of the course of receiving the drug is eight to ten weeks. It is recommended to use the product after meals or during meals with plenty of water.

What products contain

In food products, chondroitin and glucosamine are contained in small quantities and are easily destroyed by improper heat treatment - frying. Chondroprotectors are found in products of animal origin: red fish (chum salmon, salmon, salmon, trout), beef, pork, crayfish, shrimp, shellfish. To prepare a healthy dish, cook meat with bones and cartilage or fish with heads for 5-6 hours.

For vegetarians, an alternative to meat dishes is berry jelly with the obligatory addition of gelatin, which contains hydrolyzed collagen. The component activates cell growth and gives tissue elasticity. In the plant world, avocado and soy will delight in the presence of these substances.

The first is a source of chondroprotectors and antioxidants, and the second contains protein substances necessary for the musculoskeletal system.

Contraindications

individual intolerance to components;
violation of amino acid metabolism;
pregnancy, lactation period;
tendency to bleed;
blood clotting disorder;
renal or liver failure;
thrombosis with inflammation of the vein wall;
children under 12 years old.

When treated with a glucosamine-chondroitin combination, it is not recommended. It is not advisable to indulge in drinks or food with a lot of sugar.

Side effects

The drug is well tolerated by the human body, however, sometimes the following reactions are possible:

upset stomach, nausea, vomiting, gas formation;
from the neurological side: headache, dizziness, tremor, drowsiness;
lipid metabolism disorders - accumulation of fats in the blood;
tachycardia;
allergy;
swelling of the legs.

If the above symptoms occur, it is recommended to reduce the dose by 2 times.

Use with caution in patients with diabetes, arterial hypotension, heart failure, or seafood intolerance.

Prices

The cost gap for chondroprotective agents is significant, which is associated with the form of release, quantity, and manufacturer.

The price in pharmacies and specialized stores ranges from 312-8300 rubles. But if prices are fixed in pharmaceutical departments, then discounts on drugs are possible in sports stores.

Manufacturers

The complex is represented on the Russian market by domestic and foreign manufacturers. The most popular of them:

Bayer (Germany);
Queisser Pharma (Germany);
Pharmakor (Russia);
"Evalar" (Russia);
Cagmel (USA);
Unifarm (USA);
Irvin Naturals (USA);
Solgar (USA);
Panacea biotec (India);
Dear Natura (Japan).

Generics

Now let's look at analogues that are not inferior to them. Among the Russian manufacturers on the pharmacological market, the following drugs are known: “Honda Forte”, “Tazan”, “Artradollong”, “Alflutop”.

Pharmacies also sell dosage forms from other countries: “Arthra”, “Arttrovert”, “Kondronova”, “Teraflex”, “Hondra-sila”, “Solgar”, “Doppelgerts Active”.

Pharmacological drugs are partially replaced by natural ones. Fish oil, which contains vitamins A, D, as well as olive oil, has anti-inflammatory properties. Peanuts, sesame, wheat, oats, egg whites are rich in fat, which have a small effect on fat metabolism and restoration of cartilage structure.