Human immunoglobulin normal solution for intravenous administration. Immunoglobulin - what is it? Immunoglobulin (analysis): norm and deviations
Treatment of severe forms of bacterial and viral infections. Treatment of postoperative complications accompanied by bacteremia and septicopyemic conditions. Primary antibody deficiency syndrome is agamma- and hypogammaglobulinemia (congenital form, period of physiological deficiency in newborns). Secondary antibody deficiency syndrome. Blood diseases, consequences of immunosuppressive therapy, acquired immunodeficiency syndrome (AIDS), especially when children are infected with the human immunodeficiency virus.
Contraindications Human immunoglobulin normal solution for intravenous injection 50 mg/ml 25 ml
History of allergic reactions or severe systemic reactions to human blood products. In cases of severe sepsis, the only contraindication is a history of anaphylactic shock to human blood products. IgA immunodeficiency.
Directions for use and dosage Human immunoglobulin normal solution for intravenous injection 50 mg/ml 25 ml
Immunoglobulin for infusion is used only in a hospital setting. Before administration, the bottles are kept at a temperature of (20±2)°C for at least 2 hours. Solutions that are cloudy or contain sediment should not be used. The dose and frequency of administration of the drug depend on the indications for use. For children, a single dose of the drug is 3-4 ml per 1 kg of body weight, but not more than 25 ml. The infusion rate and duration of therapy are selected by the doctor individually. Immediately before administration, the drug is diluted with 0.9% sodium chloride solution or 5% glucose solution at the rate of 1 part of the drug and 4 parts of the diluent. Diluted immunoglobulin is administered intravenously at a rate of 8-10 drops per minute. Infusions are carried out daily for 3-5 days. For adults, a single dose of the drug is 25-50 ml. Immunoglobulin (without additional dilution) is administered intravenously at a rate of 30-40 drops per minute. The course of treatment consists of 3-10 transfusions, carried out every 24-72 hours (depending on the severity of the disease).
Normal human immunoglobulin
Instructions for use
Human immunoglobulin normal, solution for intramuscular administration.
R N001544/01 dated 07/08/2008
The drug is a concentrated solution of an immunologically active protein fraction, isolated by fractionation with ethyl alcohol at temperatures below 0°C from the blood plasma of healthy donors. To produce a series of immunoglobulins, plasma obtained from at least 1000 healthy donors individually tested for the absence of hepatitis B virus surface antigen (HBsAg), antibodies to the hepatitis C virus and the human immunodeficiency viruses HIV-1 and HIV-2 is used.
The protein concentration in immunoglobulin ranges from 9.5 to 10.5%.
Stabilizer glycine at a concentration of (2.25±0.75)%. The drug does not contain preservatives or antibiotics.
Transparent or slightly opalescent liquid, colorless or slightly yellow. During storage, a slight sediment may appear, which disappears after lightly shaking the drug at a temperature of (20±2)°C.
Immunological properties.
The active principle is immunoglobulins, which have antibody activity of various specificities.
The maximum concentration of antibodies in the blood is achieved after 24 - 48 hours; The half-life of antibodies from the body is 3 to 4 weeks. The drug also has nonspecific activity, increasing the body's resistance.
Purpose.
Prevention of hepatitis A, measles, whooping cough, meningococcal infection, polio, influenza, treatment of hypo- and agammaglobulinemia; increasing the body's resistance during the period of convalescence of infectious diseases.
Directions for use and dosage.
Immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteal muscle or into the outer surface of the thigh. The drug should not be administered intravenously. Before injection, ampoules with the drug are kept for 2 hours at room temperature.
The opening of the ampoules and the administration procedure are carried out in strict compliance with the rules of asepsis and antiseptics. To avoid foam formation, the drug is drawn into a syringe with a wide bore needle.
The drug cannot be stored in an opened ampoule. The drug is unsuitable for use in ampoules with damaged integrity or labeling, if there is a change in physical properties (change in color, clouding of the solution, the presence of flakes that do not break), if the expiration date has expired and storage conditions are not observed.
The dose of immunoglobulin and the frequency of its administration depend on the indications for use.
Prevention of hepatitis A.
The drug is administered once in doses: children from 1 to 6 years old - 0.75 ml: 7-10 years old - 1.5 ml; over 10 years old and adults - 3 ml.
Repeated administration of immunoglobulin if necessary to prevent hepatitis A is indicated no earlier than after 2 months.
Prevention of measles.
The drug is administered once from the age of 3 months to those who have not had measles and have not been vaccinated against this infection, no later than 6 days after contact with the patient. The dose of the drug for children (1.5 or 3 ml) is determined depending on the state of health and the time that has passed since contact. For adults, as well as children in contact with mixed infections, the drug is administered in a dose of 3 ml.
Prevention and treatment of influenza.
The drug is administered once in doses: children under 2 years old - 1.5 ml, from 2 to 7 years old - 3 ml, over 7 years old and adults - 4.5-6 ml. When treating severe forms of influenza, repeated (after 24-48 hours) administration of immunoglobulin in the same dosage is indicated.
Prevention of whooping cough.
The drug is administered twice with an interval of 24 hours in a single dose of 3 ml to children who have not had whooping cough and have not been vaccinated (not fully vaccinated) against whooping cough, as early as possible after contact with the patient, but not later than 3 days.
Prevention of meningococcal infection.
The drug is administered once to children aged 6 months to 7 years no later than 7 days after contact with a patient with a generalized form of meningococcal infection in doses of 1.5 ml (children under 3 years old) and 3 ml (children over 3 years old).
Prevention of polio.
The drug is administered once in a dose of 3 - 6 ml to children who have not been vaccinated or who have been incompletely vaccinated with polio vaccine as early as possible after contact with a patient with polio.
Treatment of hypo- and agammaglobulinemia in children.
The drug is administered at a dose of 1 ml per kg of body weight: the calculated dose can be administered in 2-3 doses with an interval of 24 hours. Subsequent administrations of immunoglobulin are carried out according to indications no earlier than after 1 month.
Increasing the body's resistance during the period of convalescence of acute infectious diseases with a protracted course and in chronic pneumonia.
The drug is administered in a single dose of 0.15-0.2 ml per kg of body weight. The frequency of administration (up to 4 injections) is determined by the attending physician, the intervals between injections are 2 - 3 days.
Side effects.
As a rule, there are no reactions to the administration of immunoglobulin. In rare cases, local reactions may develop in the form of hyperemia and an increase in temperature to 37.5 ° C during the first day after administration of the drug. Individual people with altered reactivity may develop allergic reactions of various types, and in extremely rare cases, anaphylactic shock; therefore, persons who have been administered the drug should be under medical supervision for 30 minutes after its administration. Vaccination sites must be provided with anti-shock therapy.
Interactions with other drugs.
Not installed.
Contraindications.
The use of immunoglobulin is contraindicated for persons with a history of severe allergic reactions to the administration of human blood products.
For persons suffering from allergic diseases or with a history of severe allergic reactions, antihistamines are recommended on the day of immunoglobulin administration and for the next 3 days.
Persons suffering from systemic immunopathological diseases, blood diseases, connective tissue, nephritis, etc., immunoglobulin should be administered against the background of appropriate therapy.
Immunoglobulin is used only as prescribed by a doctor. The administration of immunoglobulin is recorded in established accounting forms indicating the batch number, date of manufacture, expiration date, manufacturer, date of administration, dose, nature of the reaction to the administration of the drug.
Administration of immunoglobulin and preventive vaccinations.
After the administration of immunoglobulin, vaccinations against measles and mumps are carried out no earlier than 3 months later. After vaccination against these infections, immunoglobulin should be administered no earlier than 2 weeks later; If it is necessary to use immunoglobulin earlier than this period, vaccination against measles or mumps should be repeated. Vaccinations against other infections can be carried out at any time before or after the administration of immunoglobulin.
Release form.
In ampoules of 1.5 ml (1 dose) and 3 ml (2 doses). A) 10 ampoules in a cardboard pack with instructions for use. B) 5 or 10 ampoules in blister packs, 1 or 2 blister packs in a cardboard pack with instructions for use, an ampoule knife or an ampoule scarifier.
Thank you
Immunoglobulins(antibodies, gamma globulins) are special compounds produced by cells of the immune system that protect humans from bacteria, viruses and other foreign substances (antigens).
Properties of immunoglobulins
Immunoglobulin not only performs a protective function in the body, but is also actively used in medicine. Qualitative and quantitative determination of antibodies of various classes is used to identify various pathologies. Immunoglobulins are included in drugs for the prevention and treatment of infectious diseases and a number of other conditions.The human immune system and its functions
Normally, immunoglobulins are located on the surface of B lymphocytes and are present in blood serum, tissue fluid, and also in secretions produced by glands of the mucous membranes. Thus, different classes of antibodies provide comprehensive protection of the body from diseases, representing the so-called humoral immunity. Humoral immunity is that part of the immune system that carries out its function in the fluids of the human body. Those. Antibodies perform their work in the blood, interstitial fluids and on the surface of mucous membranes.
There is also cellular immunity, carried out by a number of specialized cells (such as macrophages). However, it has nothing to do with immunoglobulins and is a separate element of protection.
The immune response may be:
1.
Specific.
2.
Non-specific.
Immunoglobulin carries out a specific immune response, finding and neutralizing foreign microorganisms and substances. Each bacteria, virus or other agent produces its own monoclonal antibodies (that is, capable of interacting with only one antigen). For example, antistaphylococcal immunoglobulin will not help with diseases caused by other microorganisms.
Acquired immunity can be:
1.
Active:
- is formed due to antibodies formed after an illness;
- occurs after preventive vaccination (introduction of weakened or killed microorganisms, or their modified toxins, in order to form an immune response).
- immunity in the fetus and newborn child, to whom maternal antibodies were transferred in utero, or during breastfeeding;
- occurs after ready-made immunoglobulins have been vaccinated against a specific disease.
Human immunoglobulin and its functions
Human immunoglobulin performs the following functions:- “recognizes” a foreign substance (microorganism or its toxin);
- binds to antigen, forming an immune complex;
- participates in the removal or destruction of formed immune complexes;
- immunoglobulin against past diseases remains in the body for a long time (sometimes for life), which protects a person from re-infection.
Antibodies are actively used in medicines. Currently, you can buy immunoglobulin in almost any pharmacy.
Immunity and immunoglobulins in children
Features of immunity in the fetus and infant:- In utero, the child does not encounter microorganisms, so his own immune system is practically inactive;
- during pregnancy, only class G immunoglobulins can pass from mother to child, easily penetrating the placenta due to their small size;
- detection of class M immunoglobulins in the blood serum of a fetus or newborn child indicates an intrauterine infection. It is often caused by cytomegalovirus (symptoms of the disease: runny nose, fever, enlarged lymph nodes, damage to the liver and spleen, and others);
- Immunoglobulins acquired from the mother in the blood of an infant remain for about 6 months, protecting him from various diseases, therefore, in the absence of pathology of the immune system, children practically do not get sick at this time.
The development of the child’s immune system is completed only by the age of 7 years. Distinctive features of children's immunity are:
1.
Insufficient ability for phagocytosis (absorption and destruction of cells of pathogenic microorganisms by human phagocytes).
2.
Low production of interferons (proteins that provide nonspecific protection against viruses).
3.
A decrease in the amount of immunoglobulins of all classes (for example, for immunoglobulin E, the norm in children is lower than in adults).
Therefore, it is natural that during the development of the body’s immune system, the child often gets sick. To help him properly form immunity, increasing it should be achieved by such means as hardening, swimming and other sports activities, and staying in the fresh air.
Immunoglobulins during pregnancy: Rh conflict
Negative Rh in the mother during pregnancy, in combination with positive Rh in the fetus, can lead to a condition such as Rh conflict. The mechanism of development of this pathology is due to the fact that when a pregnant woman is Rh negative, immunoglobulin can begin to be produced against the red blood cells of the fetus. This usually occurs in late pregnancy. The threat of Rh conflict increases with pregnancy pathologies: inflammatory processes, threat of miscarriage, increased uterine tone, and others.
Rh conflict can lead to severe hemolysis (destruction of red blood cells) in the fetus and newborn child. The consequences of this condition may be:
- severe hypoxia (oxygen starvation) of the fetus;
- metabolic disorders, intrauterine growth retardation;
- the appearance of edema, fetal hydrops;
- miscarriages and premature births, fetal death.
Anti-Rhesus immunoglobulin during pregnancy
Anti-Rhesus immunoglobulin Rho(D) is used for the following purposes:1. Preventing the occurrence of Rh conflict in a pregnant woman with a negative Rh factor.
2.
Prevention of the formation of “harmful” immunoglobulins during abortion or other manipulations that can lead to fetal serum entering the mother’s blood.
The price for anti-Rhesus immunoglobulin is quite high, but when it comes to the health of a pregnant woman and her child, you should not save. Lower cost distinguishes domestic analogues of drugs. Therefore, you can buy Russian-made anti-Rhesus immunoglobulin, especially since there are no differences in the mechanism of action of the drugs.
Self-medication with medications containing antibodies is contraindicated. During pregnancy, other drugs, with the exception of anti-Rhesus immunoglobulin, are not used.
Determining the level of antibodies in the blood
To diagnose various diseases, methods have been developed for the qualitative and quantitative determination of antibodies in blood serum. Blood diseases and hypovitaminosis can also cause immunodeficiency. The most common of them is iron deficiency anemia, characterized by low hemoglobin content in red blood cells and a decrease in the amount of iron in the blood serum. This condition leads to oxygen starvation of tissues and, as a result, decreased immunity. Therefore, when hemoglobin is reduced, infectious diseases often occur. This is especially true for children, pregnant women or elderly patients.
Antibody affinity and avidity
Very often, not only total immunoglobulin and individual antibody fractions are determined in the blood. Typically, specialists are also interested in indicators such as avidity and affinity, determined for IgG and IgM.The avidity of antibodies allows us to identify the severity of the disease. For example, acute or recent (1-1.5 months ago) cytomegalovirus infection in children is confirmed by detecting highly avid IgM antibodies, while their low concentrations can persist for up to two years.
Affinity refers to the strength of interaction between antigens and antibodies. The higher the indicator, the better the antigens bind to antibodies. Therefore, high affinity indicates a good immune response when this disease occurs.
When is an immunoglobulin test prescribed?
A blood test for immunoglobulin E is indicated for allergic diseases:- atopic dermatitis;
- food, drug allergies;
- some other conditions.
A blood test for immunoglobulin G is indicated in the following cases:
- diagnosis of immunodeficiency conditions;
- determining the presence of antibodies against a specific disease;
- monitoring the effectiveness of therapy with drugs containing immunoglobulin.
Analysis of fractions for the determination of class M antibodies is used to identify acute infectious diseases. It is often prescribed to determine cytomegalovirus infection, Epstein-Barr virus, Helicobacter pylori bacteria, which causes gastritis and stomach ulcers, and other infections. Normally, the total amount of IgM is up to 10% of all immunoglobulins.
A blood test for immunoglobulin A is indicated for recurrent infectious diseases of the mucous membranes. The normal amount of IgA is 10-15% of the total number of immunoglobulins.
Blood is also donated for immunoglobulin for various autoimmune diseases. Specific antibodies and their complexes with antigens are determined in pathologies such as systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroiditis, myasthenia gravis and others.
Human immunoglobulin: application
Human immunoglobulin is prescribed for the following diseases:
- immunodeficiency states;
- autoimmune diseases;
- severe viral, bacterial, fungal infections;
- prevention of diseases in persons at risk (for example, in children born very prematurely).
For severe allergic diseases, your doctor may recommend purchasing antiallergic immunoglobulin. This drug is an effective remedy for atopic reactions. Indications for use will be:
- allergic dermatitis, neurodermatitis, urticaria, Quincke's edema;
- atopic bronchial asthma;
- hay fever
The importance of antibodies in vaccinations
Immunoglobulins are also used in the production of preparations for preventive vaccinations. They should not be confused with a vaccine, which is weakened or killed microorganisms, or their modified toxins. Immunoglobulins are administered in the form of serums and serve to create passive artificial immunity. Antibodies obtained from animals or human immunoglobulin can be used to produce preparations for passive immunization.
Immunoglobulin is included in preventive vaccinations against the following diseases:
- mumps (mumps);
- other.
A separate variant of immunoglobulins is toxoid. It is an antibody whose action is directed not at the causative agent of the disease, but against the toxic substances produced by it. For example, toxoids are used against tetanus and diphtheria.
There are also emergency prophylaxis products containing human immunoglobulin. Their price will be much higher, but they are indispensable when it becomes necessary to travel to another country that is an endemic zone of some dangerous infection (for example, yellow fever). Immunity after the introduction of these drugs will be shorter (up to 1 month), but is formed within a day.
However, it should be remembered that the administration of immunoglobulin is not an alternative to full preventive vaccination in accordance with the vaccination calendar, since the emerging immunity is shorter lasting and not as strong.
Immunoglobulin preparations
It is possible to increase immunity using folk remedies. Fruits, vegetables and berries with a high concentration of vitamin C (a natural antioxidant) and other vitamins and microelements are especially helpful. But in some cases, it is necessary to administer immunoglobulin to treat serious diseases and restore the body’s defenses. Normal human immunoglobulin is available in bottles containing powder for preparing an injection solution or a ready-made solution (Immunoglobulin 25 ml). It contains IgG antibodies obtained from the plasma of healthy donors, as well as small amounts of IgM and IgA.
Normal human immunoglobulin is contained in the following medications: Octagam, Pentaglobin, Antirotavirus immunoglobulin, Antistaphylococcal immunoglobulin, Normal human immunoglobulin, Complex immunoglobulin preparation (CIP), Antirhesus immunoglobulin, Antiallergic immunoglobulin, Cytotect and many others.
Immunoglobulin injections are prescribed intramuscularly or intravenously only by a qualified doctor. The dose of the drug and duration of treatment are selected individually, taking into account the patient’s age and weight, as well as the severity of the disease.
Treatment with immunoglobulins
Treatment with immunoglobulins is carried out only in a hospital, since these drugs can have a number of side effects, such as:- severe allergic reactions;
- flu-like symptoms (chills
Where to buy?
You can purchase the drug at any large pharmacy or on the Internet. Medicines containing immunoglobulin must be accompanied by instructions. However, using them without a doctor’s prescription is strictly prohibited, since the drugs have a large number of contraindications. For example, during pregnancy and breastfeeding, immunoglobulin administration is prohibited.The price of immunoglobulin preparations can vary greatly and depends on the specificity of the antibodies, the manufacturer of the drug, the release form and other characteristics.
Any medications containing normal human immunoglobulin must be stored in the refrigerator (at a temperature of +2 - +8 o C).
Before use, you should consult a specialist.
Compound
The active substance of the drug is the immunoglobulin fraction. It was isolated from human plasma and then purified and concentrated. Immunoglobulin does not contain antibodies to hepatitis C viruses and human immunodeficiency, it does not contain antibiotics.Pharmacological action
The drug is an immunomodulatory and immunostimulating agent. Contains a large number of neutralizing and opsonizing antibodies, thanks to which it effectively resists viruses, bacteria and other pathogens. The drug also replenishes the number of missing IgG antibodies, thereby reducing the risk of infection in individuals with primary and secondary immunodeficiency. Immunoglobulin effectively replaces and replenishes natural antibodies in the patient's serum.When administered intravenously, the bioavailability of the drug is 100%. A gradual redistribution of the active substance of the drug occurs between the extravascular space and human plasma. Equilibrium between these environments is achieved on average within 1 week.
Indications for use
The drug is prescribed for replacement therapy if there is a need to replenish and replace natural antibodies.Immunoglobulin is used to prevent infections in:
- agammaglobulinemia;
- bone marrow transplantation;
- primary and secondary immunodeficiency syndrome;
- chronic lymphocytic leukemia;
- variable immunodeficiency associated with agammaglobulinemia;
- AIDS in children.
The drug is also used for:
- thrombocytopenic purpura of immune origin;
- severe bacterial infections such as sepsis (in combination with antibiotics);
- viral infections;
- prevention of various infectious diseases in premature infants;
- Guillain-Barre syndrome;
- Kawasaki syndrome (usually in combination with the standard diseases for this disease);
- neutropenia of autoimmune origin;
- chronic demyelinating polyneuropathy;
- hemolytic anemia of autoimmune origin;
- erythrocyte aplasia;
- thrombocytopenia of immune origin;
- hemophilia caused by the synthesis of antibodies to factor P;
- treatment of myasthenia gravis;
- prevention of recurrent miscarriage.
Directions for use
Immunoglobulin is administered intravenously by drip and intramuscularly. The dosage is prescribed strictly individually, taking into account the type and severity of the disease, the individual tolerance of the patient and the state of his immune system.Side effects
If all recommendations for administration, dosage and precautions are followed when using the drug, then the presence of serious side effects is very rare. Symptoms may appear several hours or even days after administration. Side effects almost always disappear after stopping taking Immunoglobulin. The majority of side effects are associated with the high rate of drug infusion. By reducing the speed and temporarily stopping the intake, you can achieve the disappearance of most of the effects. In other cases, symptomatic therapy is necessary.The effects are most likely to occur when you first take the drug: during the first hour. This could be a flu-like syndrome - malaise, chills, high body temperature, weakness, headache.
The following symptoms also occur:
- respiratory system (dry cough and shortness of breath);
- digestive system (nausea, diarrhea, vomiting, stomach pain and increased salivation);
cardiovascular system (cyanosis, tachycardia, chest pain, flushing of the face);
- central nervous system (drowsiness, weakness, rarely symptoms of aseptic meningitis - nausea, vomiting, headache, photosensitivity, impaired consciousness, stiff neck);
- kidneys (rarely acute tubular necrosis, worsening renal failure in patients with impaired renal function).
Allergic (itching, bronchospasm, skin rash) and local (hyperemia at the site of intramuscular injection) reactions are also possible. Other side effects include: myalgia, aching joints, back pain, hiccups and sweating.
In very rare cases, collapse, loss of consciousness and severe hypertension have been observed. In these severe cases, discontinuation of the drug is necessary. It is also possible to administer antihistamines, adrenaline and plasma replacement solutions.
Contraindications
The drug should not be used for:- hypersensitivity to human immunoglobulins;
- IgA deficiency due to the presence of antibodies to it;
- renal failure;
- exacerbation of the allergic process;
- diabetes mellitus;
- anaphylactic shock to blood products.
The drug should be used with caution in case of migraine, pregnancy and lactation, and decompensated chronic heart failure. Also, if there are diseases in the genesis of which the main ones are immunopathological mechanisms (nephritis, collagenosis, immune blood diseases), then the drug should be prescribed with caution after the conclusion of a specialist.
Pregnancy
There have been no studies on the effect of the drug on pregnant women. There is no information about the dangers of Immunoglobulin during pregnancy and lactation. But during pregnancy, this drug is administered in case of emergency, when the benefit of the drug significantly outweighs the possible risk to the child.The drug should be used with caution during lactation: it is known that it penetrates into mother's milk and promotes the transfer of protective antibodies to the infant.
Drug interactions
The drug is pharmaceutically incompatible with other drugs. It should not be mixed with other drugs; a separate dropper should always be used for infusion. When using Immunoglobulin simultaneously with active immunization agents for viral diseases such as rubella, chicken pox, measles, and mumps, the effectiveness of treatment may decrease. If parenteral use of live viral vaccines is necessary, they can be used at least 1 month after taking Immunoglobulin. A more desirable waiting period is 3 months. If a large dose of Immunoglobulin is administered, its effect can last for a year. This drug should also not be used together with calcium gluconate in infants. There are suspicions that this will lead to negative phenomena.Overdose
Symptoms of overdose may appear with intravenous administration of the drug - increased blood viscosity and hypervolemia. This is especially true for people who are elderly or have impaired renal function.Release form
The drug is available in two forms: lyophilized dry powder for infusion (IV administration), solution for IM injection.Storage conditions
The drug must be stored in a warm place, protected from light. The storage temperature should be 2-10°C; the drug should not be frozen. The shelf life will be indicated on the packaging. After this period, the drug cannot be used.Synonyms
Immunoglobin, Imogam-RAJ, Intraglobin, Pentaglobin, Sandoglobin, Cytopect, Human normal immunoglobulin, Human antistaphylococcal immunoglobulin, Human tick-borne encephalitis immunoglobulin liquid, Human tetanus immunoglobulin, Venoglobulin, Imbiogam, Imbioglobulin, Human normal immunoglobulin (Immuno globulinum Humanum Normale), Sandoglobulin, Cytotect, Humaglobin, Octagam, Intraglobin, Endobulin S/DActive ingredient:
immunoglobulinAdditionally
The drug should be used only as prescribed by a doctor. Do not use Immunoglobulin in damaged containers. If the transparency of the solution changes, flakes and suspended particles appear, then such a solution is unsuitable for use. When opening the container, the contents must be used immediately, since the already dissolved drug cannot be stored.The protective effect of this drug begins to appear 24 hours after administration, its duration is 30 days. In patients prone to migraines or with impaired renal function, increased caution should be exercised. You should also know that after using Immunoglobulin, there is a passive increase in the amount of antibodies in the blood. In serological testing, this may lead to false interpretation of the results.
Attention!Description of the drug " Immunoglobulin"on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
